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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MICALL2-CA3 (FusionGDB2 ID:53544)

Fusion Gene Summary for MICALL2-CA3

check button Fusion gene summary
Fusion gene informationFusion gene name: MICALL2-CA3
Fusion gene ID: 53544
HgeneTgene
Gene symbol

MICALL2

CA3

Gene ID

79778

761

Gene nameMICAL like 2carbonic anhydrase 3
SynonymsJRAB|MICAL-L2CAIII|Car3
Cytomap

7p22.3

8q21.2

Type of geneprotein-codingprotein-coding
DescriptionMICAL-like protein 2junctional Rab13-binding proteinmolecule interacting with CasL-like 2carbonic anhydrase 3CA-IIIHEL-S-167mPcarbonate dehydratase IIIcarbonic anhydrase III, muscle specificcarbonic anhydrase IIIIepididymis secretory sperm binding protein Li 167mP
Modification date2020031320200313
UniProtAcc

Q8IY33

P07451

Ensembl transtripts involved in fusion geneENST00000297508, ENST00000405088, 
ENST00000471899, 		ENST00000285381, 
Fusion gene scores* DoF score12 X 8 X 8=7687 X 7 X 8=392
# samples 1613
** MAII scorelog2(16/768*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/392*10)=-1.59234203108675
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MICALL2 [Title/Abstract] AND CA3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMICALL2(1481828)-CA3(86354302), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MICALL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CA3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-V5-A7RB-01AMICALL2chr7

1481828

-CA3chr8

86354302

+
ChimerDB4ESCATCGA-V5-A7RBMICALL2chr7

1481827

-CA3chr8

86354301

+
ChimerDB4ESCATCGA-V5-A7RBMICALL2chr7

1481828

-CA3chr8

86354302

+


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Fusion Gene ORF analysis for MICALL2-CA3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000297508ENST00000285381MICALL2chr7

1481828

-CA3chr8

86354302

+
In-frameENST00000297508ENST00000285381MICALL2chr7

1481827

-CA3chr8

86354301

+
In-frameENST00000405088ENST00000285381MICALL2chr7

1481828

-CA3chr8

86354302

+
In-frameENST00000405088ENST00000285381MICALL2chr7

1481827

-CA3chr8

86354301

+
intron-3CDSENST00000471899ENST00000285381MICALL2chr7

1481828

-CA3chr8

86354302

+
intron-3CDSENST00000471899ENST00000285381MICALL2chr7

1481827

-CA3chr8

86354301

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000405088MICALL2chr71481828-ENST00000285381CA3chr886354302+2513107501625541
ENST00000297508MICALL2chr71481828-ENST00000285381CA3chr886354302+33251887922437781
ENST00000405088MICALL2chr71481827-ENST00000285381CA3chr886354301+2513107501625541
ENST00000297508MICALL2chr71481827-ENST00000285381CA3chr886354301+33251887922437781

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000405088ENST00000285381MICALL2chr71481828-CA3chr886354302+0.077918680.9220813
ENST00000297508ENST00000285381MICALL2chr71481828-CA3chr886354302+0.0174034140.9825966
ENST00000405088ENST00000285381MICALL2chr71481827-CA3chr886354301+0.077918680.9220813
ENST00000297508ENST00000285381MICALL2chr71481827-CA3chr886354301+0.0174034140.9825966

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Fusion Genomic Features for MICALL2-CA3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MICALL2-CA3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:1481828/chr8:86354302)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MICALL2

Q8IY33

CA3

P07451

FUNCTION: Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). {ECO:0000250}.FUNCTION: Reversible hydration of carbon dioxide.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMICALL2chr7:1481827chr8:86354301ENST00000297508-717356_359570905.0Compositional biasNote=Poly-Ala
HgeneMICALL2chr7:1481827chr8:86354301ENST00000297508-717392_397570905.0Compositional biasNote=Poly-Ser
HgeneMICALL2chr7:1481827chr8:86354301ENST00000405088-313356_359358693.0Compositional biasNote=Poly-Ala
HgeneMICALL2chr7:1481828chr8:86354302ENST00000297508-717356_359570905.0Compositional biasNote=Poly-Ala
HgeneMICALL2chr7:1481828chr8:86354302ENST00000297508-717392_397570905.0Compositional biasNote=Poly-Ser
HgeneMICALL2chr7:1481828chr8:86354302ENST00000405088-313356_359358693.0Compositional biasNote=Poly-Ala
HgeneMICALL2chr7:1481827chr8:86354301ENST00000297508-717186_248570905.0DomainLIM zinc-binding
HgeneMICALL2chr7:1481827chr8:86354301ENST00000297508-7171_107570905.0DomainCalponin-homology (CH)
HgeneMICALL2chr7:1481827chr8:86354301ENST00000405088-313186_248358693.0DomainLIM zinc-binding
HgeneMICALL2chr7:1481827chr8:86354301ENST00000405088-3131_107358693.0DomainCalponin-homology (CH)
HgeneMICALL2chr7:1481828chr8:86354302ENST00000297508-717186_248570905.0DomainLIM zinc-binding
HgeneMICALL2chr7:1481828chr8:86354302ENST00000297508-7171_107570905.0DomainCalponin-homology (CH)
HgeneMICALL2chr7:1481828chr8:86354302ENST00000405088-313186_248358693.0DomainLIM zinc-binding
HgeneMICALL2chr7:1481828chr8:86354302ENST00000405088-3131_107358693.0DomainCalponin-homology (CH)
TgeneCA3chr7:1481827chr8:86354301ENST0000028538117198_19977261.0RegionSubstrate binding
TgeneCA3chr7:1481828chr8:86354302ENST0000028538117198_19977261.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMICALL2chr7:1481827chr8:86354301ENST00000297508-717735_771570905.0Coiled coilOntology_term=ECO:0000255
HgeneMICALL2chr7:1481827chr8:86354301ENST00000405088-313735_771358693.0Coiled coilOntology_term=ECO:0000255
HgeneMICALL2chr7:1481828chr8:86354302ENST00000297508-717735_771570905.0Coiled coilOntology_term=ECO:0000255
HgeneMICALL2chr7:1481828chr8:86354302ENST00000405088-313735_771358693.0Coiled coilOntology_term=ECO:0000255
HgeneMICALL2chr7:1481827chr8:86354301ENST00000297508-717663_666570905.0Compositional biasNote=Poly-Arg
HgeneMICALL2chr7:1481827chr8:86354301ENST00000405088-313392_397358693.0Compositional biasNote=Poly-Ser
HgeneMICALL2chr7:1481827chr8:86354301ENST00000405088-313663_666358693.0Compositional biasNote=Poly-Arg
HgeneMICALL2chr7:1481828chr8:86354302ENST00000297508-717663_666570905.0Compositional biasNote=Poly-Arg
HgeneMICALL2chr7:1481828chr8:86354302ENST00000405088-313392_397358693.0Compositional biasNote=Poly-Ser
HgeneMICALL2chr7:1481828chr8:86354302ENST00000405088-313663_666358693.0Compositional biasNote=Poly-Arg
HgeneMICALL2chr7:1481827chr8:86354301ENST00000297508-717723_874570905.0DomainbMERB
HgeneMICALL2chr7:1481827chr8:86354301ENST00000405088-313723_874358693.0DomainbMERB
HgeneMICALL2chr7:1481828chr8:86354302ENST00000297508-717723_874570905.0DomainbMERB
HgeneMICALL2chr7:1481828chr8:86354302ENST00000405088-313723_874358693.0DomainbMERB
HgeneMICALL2chr7:1481827chr8:86354301ENST00000297508-717261_697570905.0RegionMediates targeting to the cell plasma membrane
HgeneMICALL2chr7:1481827chr8:86354301ENST00000405088-313261_697358693.0RegionMediates targeting to the cell plasma membrane
HgeneMICALL2chr7:1481828chr8:86354302ENST00000297508-717261_697570905.0RegionMediates targeting to the cell plasma membrane
HgeneMICALL2chr7:1481828chr8:86354302ENST00000405088-313261_697358693.0RegionMediates targeting to the cell plasma membrane
TgeneCA3chr7:1481827chr8:86354301ENST00000285381173_25977261.0DomainAlpha-carbonic anhydrase
TgeneCA3chr7:1481828chr8:86354302ENST00000285381173_25977261.0DomainAlpha-carbonic anhydrase
TgeneCA3chr7:1481827chr8:86354301ENST000002853811764_6777261.0RegionNote=Involved in proton transfer
TgeneCA3chr7:1481828chr8:86354302ENST000002853811764_6777261.0RegionNote=Involved in proton transfer


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Fusion Gene Sequence for MICALL2-CA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>53544_53544_1_MICALL2-CA3_MICALL2_chr7_1481827_ENST00000297508_CA3_chr8_86354301_ENST00000285381_length(transcript)=3325nt_BP=1887nt
CTTCTCTTAGGGACCCGGCACTCGTCGCCCTCAGTCCGGCTCAGCTGGGGCTGGGCGCCGTGGGTCTGGCGGTTCCGTAGCGGTCCCAGC
GTCTGTCCCGCCGGCCGGGCGGTCGCGGCACAGCCGCGGGAAGGTGTCGGAGGGCGGTTCCGCCGCGCGGCGGGCGCGCCGCCCACATGG
CGGCCATCAGGGCGCTGCAACAGTGGTGCCGGCAGCAGTGCGAGGGCTACCGCGACGTGAATATCTGCAACATGACCACGTCGTTCCGCG
ACGGCCTGGCTTTCTGCGCCATCCTGCACCGCCACCGGCCCGACCTCATAAACTTCAGTGCTCTCAAGAAGGAAAATATTTATGAAAACA
ATAAACTGGCCTTCCGCGTGGCCGAGGAGCACTTGGGCATCCCAGCCTTGCTGGATGCCGAGGACATGGTGGCCTTGAAGGTGCCTGACC
GGCTGAGCATCTTGACCTACGTGTCCCAGTATTACAACTACTTCCACGGCCGCTCCCCCATTGGGGGCATGGCAGGCGTGAAGAGGGCCT
CGGAGGACTCTGAGGAGGAGCCGTCAGGGAAGAAGGCTCCAGTCCAGGCGGCCAAGCTGCCCTCGCCCGCCCCAGCCCGGAAGCCTCCAC
TATCTCCAGCCCAGACAAACCCTGTGGTCCAGAGGAGGAATGAGGGTGCAGGGGGCCCGCCCCCCAAGACTGACCAGGCATTGGCGGGCA
GCTTGGTCAGCAGCACCTGCGGGGTCTGCGGCAAGCACGTGCACCTGGTACAGCGGCACCTGGCCGACGGGAGGCTTTACCACCGGAGCT
GCTTCAGGTGTAAGCAGTGCTCCTGCACGCTGCACTCGGGGGCCTACAAGGCCACAGGAGAGCCGGGCACCTTCGTCTGCACCAGCCACC
TCCCCGCAGCCGCCTCTGCAAGCCCCAAGTTGACGGGTCTGGTCCCCCGACAGCCAGGGGCCATGGGTGTGGATTCCAGGACCTCCTGTT
CCCCACAGAAGGCCCAGGAGGCAAACAAGGCCAGACCGTCGGCCTGGGAGCCTGCTGCGGGCAACTCGCCTGCCAGGGCTTCCGTTCCAG
CTGCACCCAACCCTGCAGCCACCAGCGCCACGTCCGTCCACGTGAGGAGCCCAGCCAGGCCCTCTGAGAGCCGCCTGGCCCCCACTCCCA
CGGAGGGGAAAGTCCGCCCTCGTGTGACCAATAGCTCCCCGATGGGCTGGTCGTCAGCTGCCCCGTGCACAGCAGCGGCTGCCTCCCATC
CCGCCGTGCCCCCGAGTGCCCCAGACCCTCGCCCGGCCACACCCCAGGGTGGGGGAGCCCCCCGAGTGGCAGCTCCTCAAACCACACTCA
GTTCAAGCTCCACATCTGCAGCCACGGTGGACCCCCCAGCCTGGACCCCGTCCGCCTCCAGGACCCAGCAGGCCCGGAATAAGTTTTTCC
AAACATCAGCAGTGCCCCCCGGCACCAGCCTTTCTGGCAGAGGTCCCACCCCGTCACTTGTTCTATCCAAGGACAGCAGCAAGGAGCAGG
CGCGGAACTTCCTCAAGCAGGCCCTCTCAGCGCTGGAAGAGGCTGGCGCTCCGGCGCCTGGCAGGCCCTCCCCAGCCACTGCCGCTGTTC
CCAGTTCTCAGCCCAAAACTGAAGCACCACAAGCAAGTCCCTTAGCCAAGCCGTTACAGTCCTCGTCTCCCCGGGTGCTTGGCCTCCCTT
CGAGGATGGAACCGCCAGCCCCGCTGAGCACGAGCAGTACCTCTCAGGCATCCGCGTTGCCCCCGGCAGGCAGGAGGAACTTGGCGGAAT
CCTCAGGGGTCGGCAGGGTGGGTGCTGGCTCCAGGCCGAAGCCAGAGGCCCCGATGGCAAAGGGTAAAAGCACCACCTTAACGCAGGTGC
TGAGAGGGGGTCCTCTCCCTGGACCCTACCGACTTCGCCAGTTTCATCTTCACTGGGGCTCTTCGGATGATCATGGCTCTGAGCACACCG
TGGATGGAGTCAAGTATGCAGCGGAGCTTCATTTGGTTCACTGGAACCCGAAGTATAACACTTTTAAAGAAGCCCTGAAGCAGCGCGATG
GGATCGCTGTGATTGGCATTTTTCTGAAGATAGGACATGAGAATGGCGAGTTCCAGATTTTCCTTGATGCATTGGACAAGATTAAGACAA
AGGGCAAGGAGGCGCCCTTCACAAAGTTTGACCCATCCTGCCTGTTCCCGGCATGCCGGGACTACTGGACCTACCAGGGCTCATTCACCA
CGCCGCCCTGCGAGGAATGCATTGTGTGGCTGCTGCTGAAGGAGCCCATGACCGTGAGCTCTGACCAGATGGCCAAGCTGCGGAGCCTCC
TCTCCAGTGCTGAGAACGAGCCCCCAGTGCCTCTTGTGAGCAACTGGCGACCTCCACAGCCTATCAATAACAGGGTGGTGAGAGCTTCCT
TCAAATGAGGCTGCTGGATCTTGCCCTCTTCAGGAAAGGAAACCTACCATTGGAGAGCTTGGTTCCTTGCCTCCTTCTGGTGCTCCTTAC
TCCAAGTCTATTTCATTTTTCCACACTGAGCAATGAATGTGAGAGATGTGGTCACCAAGATCTAAGTTACTTGTTGAAAGAAAGTTACTT
TCGACAAGATCTAATATGAAAGCATAGATTTCACATTTGATCTCTGTAATAATCATCTTTCCTATAAAAGTAGCATTTTTGGTAAAGTTT
CAAAGAAGAAGAAACAGAGATGGAAGAGTAAAGATATTTTTAAAATGGCTAGCTATTGGGCACCAGTTTTTCTGTTATCTAAAATTTCAC
ACAACTTCATTGTTTTTATTTTTATATTATGAGTTGTCCATCTTAAAGAAATATGAGTAATTCTACATGTAGTAGAGGTGTATGAAGATC
ATATAACAATTAAACATAAGCCAGAAATTAAAATGACTATAGACAGCAAGAATTGAGCTAATAATATGTTTTAACTCTTAACACCAGCAA
GAAGTCAGTCATTTATTGAAGTTTTAGCTACTAAGATTACTTGGTTTTGATTACCAGTGAAAAGAAAACACAATACAATCAGGAGTTTTC
AAATTTTTGATTCAGTATTTGAATTTCTTCTTCATAAATGTAGTTGAATTTATCCTAGTATTTTTCTTTACCTGAAGGAGGGCCATTTAT
TTTTAATTTCACTACATTTTTCTTTGCATGATTATTAAAATAAAAACTGCCTCTGTTGTGTTTCTCACTGGAGGCTGGAATGAATGATCA

>53544_53544_1_MICALL2-CA3_MICALL2_chr7_1481827_ENST00000297508_CA3_chr8_86354301_ENST00000285381_length(amino acids)=781AA_BP=598
MSRRPGGRGTAAGRCRRAVPPRGGRAAHMAAIRALQQWCRQQCEGYRDVNICNMTTSFRDGLAFCAILHRHRPDLINFSALKKENIYENN
KLAFRVAEEHLGIPALLDAEDMVALKVPDRLSILTYVSQYYNYFHGRSPIGGMAGVKRASEDSEEEPSGKKAPVQAAKLPSPAPARKPPL
SPAQTNPVVQRRNEGAGGPPPKTDQALAGSLVSSTCGVCGKHVHLVQRHLADGRLYHRSCFRCKQCSCTLHSGAYKATGEPGTFVCTSHL
PAAASASPKLTGLVPRQPGAMGVDSRTSCSPQKAQEANKARPSAWEPAAGNSPARASVPAAPNPAATSATSVHVRSPARPSESRLAPTPT
EGKVRPRVTNSSPMGWSSAAPCTAAAASHPAVPPSAPDPRPATPQGGGAPRVAAPQTTLSSSSTSAATVDPPAWTPSASRTQQARNKFFQ
TSAVPPGTSLSGRGPTPSLVLSKDSSKEQARNFLKQALSALEEAGAPAPGRPSPATAAVPSSQPKTEAPQASPLAKPLQSSSPRVLGLPS
RMEPPAPLSTSSTSQASALPPAGRRNLAESSGVGRVGAGSRPKPEAPMAKGKSTTLTQVLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTV
DGVKYAAELHLVHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDPSCLFPACRDYWTYQGSFTT

--------------------------------------------------------------
>53544_53544_2_MICALL2-CA3_MICALL2_chr7_1481827_ENST00000405088_CA3_chr8_86354301_ENST00000285381_length(transcript)=2513nt_BP=1075nt
ATGGCGGCCATCAGGGCGCTGCAACAGTGGTGCCGGCAGCAGTGCGAGGGCTACCGCGACGTGAATATCTGCAACATGACCACCCACCTC
CCCGCAGCCGCCTCTGCAAGCCCCAAGTTGACGGGTCTGGTCCCCCGACAGCCAGGGGCCATGGGTGTGGATTCCAGGACCTCCTGTTCC
CCACAGAAGGCCCAGGAGGCAAACAAGGCCAGACCGTCGGCCTGGGAGCCTGCTGCGGGCAACTCGCCTGCCAGGGCTTCCGTTCCAGCT
GCACCCAACCCTGCAGCCACCAGCGCCACGTCCGTCCACGTGAGGAGCCCAGCCAGGCCCTCTGAGAGCCGCCTGGCCCCCACTCCCACG
GAGGGGAAAGTCCGCCCTCGTGTGACCAATAGCTCCCCGATGGGCTGGTCGTCAGCTGCCCCGTGCACAGCAGCGGCTGCCTCCCATCCC
GCCGTGCCCCCGAGTGCCCCAGACCCTCGCCCGGCCACACCCCAGGGTGGGGGAGCCCCCCGAGTGGCAGCTCCTCAAACCACACTCAGT
TCAAGCTCCACATCTGCAGCCACGGTGGACCCCCCAGCCTGGACCCCGTCCGCCTCCAGGACCCAGCAGGCCCGGAATAAGTTTTTCCAA
ACATCAGCAGTGCCCCCCGGCACCAGCCTTTCTGGCAGAGGTCCCACCCCGTCACTTGTTCTATCCAAGGACAGCAGCAAGGAGCAGGCG
CGGAACTTCCTCAAGCAGGCCCTCTCAGCGCTGGAAGAGGCTGGCGCTCCGGCGCCTGGCAGGCCCTCCCCAGCCACTGCCGCTGTTCCC
AGTTCTCAGCCCAAAACTGAAGCACCACAAGCAAGTCCCTTAGCCAAGCCGTTACAGTCCTCGTCTCCCCGGGTGCTTGGCCTCCCTTCG
AGGATGGAACCGCCAGCCCCGCTGAGCACGAGCAGTACCTCTCAGGCATCCGCGTTGCCCCCGGCAGGCAGGAGGAACTTGGCGGAATCC
TCAGGGGTCGGCAGGGTGGGTGCTGGCTCCAGGCCGAAGCCAGAGGCCCCGATGGCAAAGGGTAAAAGCACCACCTTAACGCAGGTGCTG
AGAGGGGGTCCTCTCCCTGGACCCTACCGACTTCGCCAGTTTCATCTTCACTGGGGCTCTTCGGATGATCATGGCTCTGAGCACACCGTG
GATGGAGTCAAGTATGCAGCGGAGCTTCATTTGGTTCACTGGAACCCGAAGTATAACACTTTTAAAGAAGCCCTGAAGCAGCGCGATGGG
ATCGCTGTGATTGGCATTTTTCTGAAGATAGGACATGAGAATGGCGAGTTCCAGATTTTCCTTGATGCATTGGACAAGATTAAGACAAAG
GGCAAGGAGGCGCCCTTCACAAAGTTTGACCCATCCTGCCTGTTCCCGGCATGCCGGGACTACTGGACCTACCAGGGCTCATTCACCACG
CCGCCCTGCGAGGAATGCATTGTGTGGCTGCTGCTGAAGGAGCCCATGACCGTGAGCTCTGACCAGATGGCCAAGCTGCGGAGCCTCCTC
TCCAGTGCTGAGAACGAGCCCCCAGTGCCTCTTGTGAGCAACTGGCGACCTCCACAGCCTATCAATAACAGGGTGGTGAGAGCTTCCTTC
AAATGAGGCTGCTGGATCTTGCCCTCTTCAGGAAAGGAAACCTACCATTGGAGAGCTTGGTTCCTTGCCTCCTTCTGGTGCTCCTTACTC
CAAGTCTATTTCATTTTTCCACACTGAGCAATGAATGTGAGAGATGTGGTCACCAAGATCTAAGTTACTTGTTGAAAGAAAGTTACTTTC
GACAAGATCTAATATGAAAGCATAGATTTCACATTTGATCTCTGTAATAATCATCTTTCCTATAAAAGTAGCATTTTTGGTAAAGTTTCA
AAGAAGAAGAAACAGAGATGGAAGAGTAAAGATATTTTTAAAATGGCTAGCTATTGGGCACCAGTTTTTCTGTTATCTAAAATTTCACAC
AACTTCATTGTTTTTATTTTTATATTATGAGTTGTCCATCTTAAAGAAATATGAGTAATTCTACATGTAGTAGAGGTGTATGAAGATCAT
ATAACAATTAAACATAAGCCAGAAATTAAAATGACTATAGACAGCAAGAATTGAGCTAATAATATGTTTTAACTCTTAACACCAGCAAGA
AGTCAGTCATTTATTGAAGTTTTAGCTACTAAGATTACTTGGTTTTGATTACCAGTGAAAAGAAAACACAATACAATCAGGAGTTTTCAA
ATTTTTGATTCAGTATTTGAATTTCTTCTTCATAAATGTAGTTGAATTTATCCTAGTATTTTTCTTTACCTGAAGGAGGGCCATTTATTT
TTAATTTCACTACATTTTTCTTTGCATGATTATTAAAATAAAAACTGCCTCTGTTGTGTTTCTCACTGGAGGCTGGAATGAATGATCACT

>53544_53544_2_MICALL2-CA3_MICALL2_chr7_1481827_ENST00000405088_CA3_chr8_86354301_ENST00000285381_length(amino acids)=541AA_BP=358
MAAIRALQQWCRQQCEGYRDVNICNMTTHLPAAASASPKLTGLVPRQPGAMGVDSRTSCSPQKAQEANKARPSAWEPAAGNSPARASVPA
APNPAATSATSVHVRSPARPSESRLAPTPTEGKVRPRVTNSSPMGWSSAAPCTAAAASHPAVPPSAPDPRPATPQGGGAPRVAAPQTTLS
SSSTSAATVDPPAWTPSASRTQQARNKFFQTSAVPPGTSLSGRGPTPSLVLSKDSSKEQARNFLKQALSALEEAGAPAPGRPSPATAAVP
SSQPKTEAPQASPLAKPLQSSSPRVLGLPSRMEPPAPLSTSSTSQASALPPAGRRNLAESSGVGRVGAGSRPKPEAPMAKGKSTTLTQVL
RGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTK
GKEAPFTKFDPSCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPLVSNWRPPQPINNRVVRASF

--------------------------------------------------------------
>53544_53544_3_MICALL2-CA3_MICALL2_chr7_1481828_ENST00000297508_CA3_chr8_86354302_ENST00000285381_length(transcript)=3325nt_BP=1887nt
CTTCTCTTAGGGACCCGGCACTCGTCGCCCTCAGTCCGGCTCAGCTGGGGCTGGGCGCCGTGGGTCTGGCGGTTCCGTAGCGGTCCCAGC
GTCTGTCCCGCCGGCCGGGCGGTCGCGGCACAGCCGCGGGAAGGTGTCGGAGGGCGGTTCCGCCGCGCGGCGGGCGCGCCGCCCACATGG
CGGCCATCAGGGCGCTGCAACAGTGGTGCCGGCAGCAGTGCGAGGGCTACCGCGACGTGAATATCTGCAACATGACCACGTCGTTCCGCG
ACGGCCTGGCTTTCTGCGCCATCCTGCACCGCCACCGGCCCGACCTCATAAACTTCAGTGCTCTCAAGAAGGAAAATATTTATGAAAACA
ATAAACTGGCCTTCCGCGTGGCCGAGGAGCACTTGGGCATCCCAGCCTTGCTGGATGCCGAGGACATGGTGGCCTTGAAGGTGCCTGACC
GGCTGAGCATCTTGACCTACGTGTCCCAGTATTACAACTACTTCCACGGCCGCTCCCCCATTGGGGGCATGGCAGGCGTGAAGAGGGCCT
CGGAGGACTCTGAGGAGGAGCCGTCAGGGAAGAAGGCTCCAGTCCAGGCGGCCAAGCTGCCCTCGCCCGCCCCAGCCCGGAAGCCTCCAC
TATCTCCAGCCCAGACAAACCCTGTGGTCCAGAGGAGGAATGAGGGTGCAGGGGGCCCGCCCCCCAAGACTGACCAGGCATTGGCGGGCA
GCTTGGTCAGCAGCACCTGCGGGGTCTGCGGCAAGCACGTGCACCTGGTACAGCGGCACCTGGCCGACGGGAGGCTTTACCACCGGAGCT
GCTTCAGGTGTAAGCAGTGCTCCTGCACGCTGCACTCGGGGGCCTACAAGGCCACAGGAGAGCCGGGCACCTTCGTCTGCACCAGCCACC
TCCCCGCAGCCGCCTCTGCAAGCCCCAAGTTGACGGGTCTGGTCCCCCGACAGCCAGGGGCCATGGGTGTGGATTCCAGGACCTCCTGTT
CCCCACAGAAGGCCCAGGAGGCAAACAAGGCCAGACCGTCGGCCTGGGAGCCTGCTGCGGGCAACTCGCCTGCCAGGGCTTCCGTTCCAG
CTGCACCCAACCCTGCAGCCACCAGCGCCACGTCCGTCCACGTGAGGAGCCCAGCCAGGCCCTCTGAGAGCCGCCTGGCCCCCACTCCCA
CGGAGGGGAAAGTCCGCCCTCGTGTGACCAATAGCTCCCCGATGGGCTGGTCGTCAGCTGCCCCGTGCACAGCAGCGGCTGCCTCCCATC
CCGCCGTGCCCCCGAGTGCCCCAGACCCTCGCCCGGCCACACCCCAGGGTGGGGGAGCCCCCCGAGTGGCAGCTCCTCAAACCACACTCA
GTTCAAGCTCCACATCTGCAGCCACGGTGGACCCCCCAGCCTGGACCCCGTCCGCCTCCAGGACCCAGCAGGCCCGGAATAAGTTTTTCC
AAACATCAGCAGTGCCCCCCGGCACCAGCCTTTCTGGCAGAGGTCCCACCCCGTCACTTGTTCTATCCAAGGACAGCAGCAAGGAGCAGG
CGCGGAACTTCCTCAAGCAGGCCCTCTCAGCGCTGGAAGAGGCTGGCGCTCCGGCGCCTGGCAGGCCCTCCCCAGCCACTGCCGCTGTTC
CCAGTTCTCAGCCCAAAACTGAAGCACCACAAGCAAGTCCCTTAGCCAAGCCGTTACAGTCCTCGTCTCCCCGGGTGCTTGGCCTCCCTT
CGAGGATGGAACCGCCAGCCCCGCTGAGCACGAGCAGTACCTCTCAGGCATCCGCGTTGCCCCCGGCAGGCAGGAGGAACTTGGCGGAAT
CCTCAGGGGTCGGCAGGGTGGGTGCTGGCTCCAGGCCGAAGCCAGAGGCCCCGATGGCAAAGGGTAAAAGCACCACCTTAACGCAGGTGC
TGAGAGGGGGTCCTCTCCCTGGACCCTACCGACTTCGCCAGTTTCATCTTCACTGGGGCTCTTCGGATGATCATGGCTCTGAGCACACCG
TGGATGGAGTCAAGTATGCAGCGGAGCTTCATTTGGTTCACTGGAACCCGAAGTATAACACTTTTAAAGAAGCCCTGAAGCAGCGCGATG
GGATCGCTGTGATTGGCATTTTTCTGAAGATAGGACATGAGAATGGCGAGTTCCAGATTTTCCTTGATGCATTGGACAAGATTAAGACAA
AGGGCAAGGAGGCGCCCTTCACAAAGTTTGACCCATCCTGCCTGTTCCCGGCATGCCGGGACTACTGGACCTACCAGGGCTCATTCACCA
CGCCGCCCTGCGAGGAATGCATTGTGTGGCTGCTGCTGAAGGAGCCCATGACCGTGAGCTCTGACCAGATGGCCAAGCTGCGGAGCCTCC
TCTCCAGTGCTGAGAACGAGCCCCCAGTGCCTCTTGTGAGCAACTGGCGACCTCCACAGCCTATCAATAACAGGGTGGTGAGAGCTTCCT
TCAAATGAGGCTGCTGGATCTTGCCCTCTTCAGGAAAGGAAACCTACCATTGGAGAGCTTGGTTCCTTGCCTCCTTCTGGTGCTCCTTAC
TCCAAGTCTATTTCATTTTTCCACACTGAGCAATGAATGTGAGAGATGTGGTCACCAAGATCTAAGTTACTTGTTGAAAGAAAGTTACTT
TCGACAAGATCTAATATGAAAGCATAGATTTCACATTTGATCTCTGTAATAATCATCTTTCCTATAAAAGTAGCATTTTTGGTAAAGTTT
CAAAGAAGAAGAAACAGAGATGGAAGAGTAAAGATATTTTTAAAATGGCTAGCTATTGGGCACCAGTTTTTCTGTTATCTAAAATTTCAC
ACAACTTCATTGTTTTTATTTTTATATTATGAGTTGTCCATCTTAAAGAAATATGAGTAATTCTACATGTAGTAGAGGTGTATGAAGATC
ATATAACAATTAAACATAAGCCAGAAATTAAAATGACTATAGACAGCAAGAATTGAGCTAATAATATGTTTTAACTCTTAACACCAGCAA
GAAGTCAGTCATTTATTGAAGTTTTAGCTACTAAGATTACTTGGTTTTGATTACCAGTGAAAAGAAAACACAATACAATCAGGAGTTTTC
AAATTTTTGATTCAGTATTTGAATTTCTTCTTCATAAATGTAGTTGAATTTATCCTAGTATTTTTCTTTACCTGAAGGAGGGCCATTTAT
TTTTAATTTCACTACATTTTTCTTTGCATGATTATTAAAATAAAAACTGCCTCTGTTGTGTTTCTCACTGGAGGCTGGAATGAATGATCA

>53544_53544_3_MICALL2-CA3_MICALL2_chr7_1481828_ENST00000297508_CA3_chr8_86354302_ENST00000285381_length(amino acids)=781AA_BP=598
MSRRPGGRGTAAGRCRRAVPPRGGRAAHMAAIRALQQWCRQQCEGYRDVNICNMTTSFRDGLAFCAILHRHRPDLINFSALKKENIYENN
KLAFRVAEEHLGIPALLDAEDMVALKVPDRLSILTYVSQYYNYFHGRSPIGGMAGVKRASEDSEEEPSGKKAPVQAAKLPSPAPARKPPL
SPAQTNPVVQRRNEGAGGPPPKTDQALAGSLVSSTCGVCGKHVHLVQRHLADGRLYHRSCFRCKQCSCTLHSGAYKATGEPGTFVCTSHL
PAAASASPKLTGLVPRQPGAMGVDSRTSCSPQKAQEANKARPSAWEPAAGNSPARASVPAAPNPAATSATSVHVRSPARPSESRLAPTPT
EGKVRPRVTNSSPMGWSSAAPCTAAAASHPAVPPSAPDPRPATPQGGGAPRVAAPQTTLSSSSTSAATVDPPAWTPSASRTQQARNKFFQ
TSAVPPGTSLSGRGPTPSLVLSKDSSKEQARNFLKQALSALEEAGAPAPGRPSPATAAVPSSQPKTEAPQASPLAKPLQSSSPRVLGLPS
RMEPPAPLSTSSTSQASALPPAGRRNLAESSGVGRVGAGSRPKPEAPMAKGKSTTLTQVLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTV
DGVKYAAELHLVHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDPSCLFPACRDYWTYQGSFTT

--------------------------------------------------------------
>53544_53544_4_MICALL2-CA3_MICALL2_chr7_1481828_ENST00000405088_CA3_chr8_86354302_ENST00000285381_length(transcript)=2513nt_BP=1075nt
ATGGCGGCCATCAGGGCGCTGCAACAGTGGTGCCGGCAGCAGTGCGAGGGCTACCGCGACGTGAATATCTGCAACATGACCACCCACCTC
CCCGCAGCCGCCTCTGCAAGCCCCAAGTTGACGGGTCTGGTCCCCCGACAGCCAGGGGCCATGGGTGTGGATTCCAGGACCTCCTGTTCC
CCACAGAAGGCCCAGGAGGCAAACAAGGCCAGACCGTCGGCCTGGGAGCCTGCTGCGGGCAACTCGCCTGCCAGGGCTTCCGTTCCAGCT
GCACCCAACCCTGCAGCCACCAGCGCCACGTCCGTCCACGTGAGGAGCCCAGCCAGGCCCTCTGAGAGCCGCCTGGCCCCCACTCCCACG
GAGGGGAAAGTCCGCCCTCGTGTGACCAATAGCTCCCCGATGGGCTGGTCGTCAGCTGCCCCGTGCACAGCAGCGGCTGCCTCCCATCCC
GCCGTGCCCCCGAGTGCCCCAGACCCTCGCCCGGCCACACCCCAGGGTGGGGGAGCCCCCCGAGTGGCAGCTCCTCAAACCACACTCAGT
TCAAGCTCCACATCTGCAGCCACGGTGGACCCCCCAGCCTGGACCCCGTCCGCCTCCAGGACCCAGCAGGCCCGGAATAAGTTTTTCCAA
ACATCAGCAGTGCCCCCCGGCACCAGCCTTTCTGGCAGAGGTCCCACCCCGTCACTTGTTCTATCCAAGGACAGCAGCAAGGAGCAGGCG
CGGAACTTCCTCAAGCAGGCCCTCTCAGCGCTGGAAGAGGCTGGCGCTCCGGCGCCTGGCAGGCCCTCCCCAGCCACTGCCGCTGTTCCC
AGTTCTCAGCCCAAAACTGAAGCACCACAAGCAAGTCCCTTAGCCAAGCCGTTACAGTCCTCGTCTCCCCGGGTGCTTGGCCTCCCTTCG
AGGATGGAACCGCCAGCCCCGCTGAGCACGAGCAGTACCTCTCAGGCATCCGCGTTGCCCCCGGCAGGCAGGAGGAACTTGGCGGAATCC
TCAGGGGTCGGCAGGGTGGGTGCTGGCTCCAGGCCGAAGCCAGAGGCCCCGATGGCAAAGGGTAAAAGCACCACCTTAACGCAGGTGCTG
AGAGGGGGTCCTCTCCCTGGACCCTACCGACTTCGCCAGTTTCATCTTCACTGGGGCTCTTCGGATGATCATGGCTCTGAGCACACCGTG
GATGGAGTCAAGTATGCAGCGGAGCTTCATTTGGTTCACTGGAACCCGAAGTATAACACTTTTAAAGAAGCCCTGAAGCAGCGCGATGGG
ATCGCTGTGATTGGCATTTTTCTGAAGATAGGACATGAGAATGGCGAGTTCCAGATTTTCCTTGATGCATTGGACAAGATTAAGACAAAG
GGCAAGGAGGCGCCCTTCACAAAGTTTGACCCATCCTGCCTGTTCCCGGCATGCCGGGACTACTGGACCTACCAGGGCTCATTCACCACG
CCGCCCTGCGAGGAATGCATTGTGTGGCTGCTGCTGAAGGAGCCCATGACCGTGAGCTCTGACCAGATGGCCAAGCTGCGGAGCCTCCTC
TCCAGTGCTGAGAACGAGCCCCCAGTGCCTCTTGTGAGCAACTGGCGACCTCCACAGCCTATCAATAACAGGGTGGTGAGAGCTTCCTTC
AAATGAGGCTGCTGGATCTTGCCCTCTTCAGGAAAGGAAACCTACCATTGGAGAGCTTGGTTCCTTGCCTCCTTCTGGTGCTCCTTACTC
CAAGTCTATTTCATTTTTCCACACTGAGCAATGAATGTGAGAGATGTGGTCACCAAGATCTAAGTTACTTGTTGAAAGAAAGTTACTTTC
GACAAGATCTAATATGAAAGCATAGATTTCACATTTGATCTCTGTAATAATCATCTTTCCTATAAAAGTAGCATTTTTGGTAAAGTTTCA
AAGAAGAAGAAACAGAGATGGAAGAGTAAAGATATTTTTAAAATGGCTAGCTATTGGGCACCAGTTTTTCTGTTATCTAAAATTTCACAC
AACTTCATTGTTTTTATTTTTATATTATGAGTTGTCCATCTTAAAGAAATATGAGTAATTCTACATGTAGTAGAGGTGTATGAAGATCAT
ATAACAATTAAACATAAGCCAGAAATTAAAATGACTATAGACAGCAAGAATTGAGCTAATAATATGTTTTAACTCTTAACACCAGCAAGA
AGTCAGTCATTTATTGAAGTTTTAGCTACTAAGATTACTTGGTTTTGATTACCAGTGAAAAGAAAACACAATACAATCAGGAGTTTTCAA
ATTTTTGATTCAGTATTTGAATTTCTTCTTCATAAATGTAGTTGAATTTATCCTAGTATTTTTCTTTACCTGAAGGAGGGCCATTTATTT
TTAATTTCACTACATTTTTCTTTGCATGATTATTAAAATAAAAACTGCCTCTGTTGTGTTTCTCACTGGAGGCTGGAATGAATGATCACT

>53544_53544_4_MICALL2-CA3_MICALL2_chr7_1481828_ENST00000405088_CA3_chr8_86354302_ENST00000285381_length(amino acids)=541AA_BP=358
MAAIRALQQWCRQQCEGYRDVNICNMTTHLPAAASASPKLTGLVPRQPGAMGVDSRTSCSPQKAQEANKARPSAWEPAAGNSPARASVPA
APNPAATSATSVHVRSPARPSESRLAPTPTEGKVRPRVTNSSPMGWSSAAPCTAAAASHPAVPPSAPDPRPATPQGGGAPRVAAPQTTLS
SSSTSAATVDPPAWTPSASRTQQARNKFFQTSAVPPGTSLSGRGPTPSLVLSKDSSKEQARNFLKQALSALEEAGAPAPGRPSPATAAVP
SSQPKTEAPQASPLAKPLQSSSPRVLGLPSRMEPPAPLSTSSTSQASALPPAGRRNLAESSGVGRVGAGSRPKPEAPMAKGKSTTLTQVL
RGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTK
GKEAPFTKFDPSCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPLVSNWRPPQPINNRVVRASF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MICALL2-CA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MICALL2-CA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MICALL2-CA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource