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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MICU2-ITM2B (FusionGDB2 ID:53582) |
Fusion Gene Summary for MICU2-ITM2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MICU2-ITM2B | Fusion gene ID: 53582 | Hgene | Tgene | Gene symbol | MICU2 | ITM2B | Gene ID | 221154 | 9445 |
| Gene name | mitochondrial calcium uptake 2 | integral membrane protein 2B | |
| Synonyms | 1110008L20Rik|EFHA1 | ABRI|BRI|BRI2|BRICD2B|E25B|E3-16|FBD|RDGCA|imBRI2 | |
| Cytomap | 13q12.11 | 13q14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calcium uptake protein 2, mitochondrialEF hand domain family A1EF hand domain family, member A1EF-hand domain-containing family member A1Smhs2 homolog | integral membrane protein 2BABri/ADan amyloid peptideBRICHOS domain containing 2Bepididymis secretory sperm binding proteinimmature BRI2transmembrane protein BRI | |
| Modification date | 20200315 | 20200313 | |
| UniProtAcc | Q8IYU8 | Q9Y287 | |
| Ensembl transtripts involved in fusion gene | ENST00000382374, ENST00000479790, | ENST00000378549, ENST00000378565, | |
| Fusion gene scores | * DoF score | 5 X 3 X 3=45 | 19 X 11 X 7=1463 |
| # samples | 5 | 22 | |
| ** MAII score | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(22/1463*10)=-2.73335434061383 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MICU2 [Title/Abstract] AND ITM2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MICU2(22178078)-ITM2B(48827944), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MICU2 | GO:0006851 | mitochondrial calcium ion transmembrane transport | 24560927 |
| Hgene | MICU2 | GO:0051562 | negative regulation of mitochondrial calcium ion concentration | 24560927 |
| Tgene | ITM2B | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process | 16027166|18524908 |
| Fusion gene breakpoints across MICU2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ITM2B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-8078-01A | MICU2 | chr13 | 22178078 | - | ITM2B | chr13 | 48827944 | + |
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Fusion Gene ORF analysis for MICU2-ITM2B |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000382374 | ENST00000378549 | MICU2 | chr13 | 22178078 | - | ITM2B | chr13 | 48827944 | + |
| In-frame | ENST00000382374 | ENST00000378565 | MICU2 | chr13 | 22178078 | - | ITM2B | chr13 | 48827944 | + |
| intron-3CDS | ENST00000479790 | ENST00000378549 | MICU2 | chr13 | 22178078 | - | ITM2B | chr13 | 48827944 | + |
| intron-3CDS | ENST00000479790 | ENST00000378565 | MICU2 | chr13 | 22178078 | - | ITM2B | chr13 | 48827944 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000382374 | MICU2 | chr13 | 22178078 | - | ENST00000378565 | ITM2B | chr13 | 48827944 | + | 2060 | 276 | 66 | 959 | 297 |
| ENST00000382374 | MICU2 | chr13 | 22178078 | - | ENST00000378549 | ITM2B | chr13 | 48827944 | + | 806 | 276 | 66 | 641 | 191 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000382374 | ENST00000378565 | MICU2 | chr13 | 22178078 | - | ITM2B | chr13 | 48827944 | + | 0.000204901 | 0.99979514 |
| ENST00000382374 | ENST00000378549 | MICU2 | chr13 | 22178078 | - | ITM2B | chr13 | 48827944 | + | 0.013687715 | 0.9863123 |
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Fusion Genomic Features for MICU2-ITM2B |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MICU2-ITM2B |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:22178078/chr13:48827944) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MICU2 | ITM2B |
| FUNCTION: Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927). {ECO:0000269|PubMed:24503055, ECO:0000269|PubMed:24560927, ECO:0000269|PubMed:26387864, ECO:0000269|PubMed:26903221}. | FUNCTION: Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.; FUNCTION: Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.; FUNCTION: Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MICU2 | chr13:22178078 | chr13:48827944 | ENST00000382374 | - | 1 | 12 | 2_50 | 70 | 435.0 | Compositional bias | Note=Ala-rich |
| Tgene | ITM2B | chr13:22178078 | chr13:48827944 | ENST00000378565 | 0 | 6 | 137_231 | 39 | 267.0 | Domain | BRICHOS | |
| Tgene | ITM2B | chr13:22178078 | chr13:48827944 | ENST00000378565 | 0 | 6 | 76_266 | 39 | 267.0 | Topological domain | Lumenal | |
| Tgene | ITM2B | chr13:22178078 | chr13:48827944 | ENST00000378565 | 0 | 6 | 55_75 | 39 | 267.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MICU2 | chr13:22178078 | chr13:48827944 | ENST00000382374 | - | 1 | 12 | 172_207 | 70 | 435.0 | Domain | EF-hand 1 |
| Hgene | MICU2 | chr13:22178078 | chr13:48827944 | ENST00000382374 | - | 1 | 12 | 227_262 | 70 | 435.0 | Domain | EF-hand 2 |
| Hgene | MICU2 | chr13:22178078 | chr13:48827944 | ENST00000382374 | - | 1 | 12 | 293_328 | 70 | 435.0 | Domain | EF-hand 3 |
| Hgene | MICU2 | chr13:22178078 | chr13:48827944 | ENST00000382374 | - | 1 | 12 | 362_397 | 70 | 435.0 | Domain | EF-hand 4 |
| Tgene | ITM2B | chr13:22178078 | chr13:48827944 | ENST00000378565 | 0 | 6 | 1_54 | 39 | 267.0 | Topological domain | Cytoplasmic |
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Fusion Gene Sequence for MICU2-ITM2B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >53582_53582_1_MICU2-ITM2B_MICU2_chr13_22178078_ENST00000382374_ITM2B_chr13_48827944_ENST00000378549_length(transcript)=806nt_BP=276nt GAGAGTTCCCAAGCGGTAGGCGGCGGCGCCGGGAGAGAAGCGCCGCCTAGCTGCGCTTCCGCAAAGATGGCGGCGGCTGCGGGTAGCTGC GCGCGGGTGGCGGCCTGGGGCGGAAAACTGCGACGGGGGCTCGCTGTCAGCCGACAGGCTGTGCGGAGTCCCGGCCCCTTGGCAGCGGCA GTGGCCGGCGCGGCCCTGGCAGGAGCAGGAGCGGCCTGGCACCACAGCCGCGTCAGTGTTGCGGCGCGGGATGGCAGTTTTACAGTCTCC GCACAGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGT GTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATG GTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGC AGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTA ATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATT >53582_53582_1_MICU2-ITM2B_MICU2_chr13_22178078_ENST00000382374_ITM2B_chr13_48827944_ENST00000378549_length(amino acids)=191AA_BP=70 MAAAAGSCARVAAWGGKLRRGLAVSRQAVRSPGPLAAAVAGAALAGAGAAWHHSRVSVAARDGSFTVSAQDPDDVVPVGQRRAWCWCMCF GLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREASNCFAIRHFE -------------------------------------------------------------- >53582_53582_2_MICU2-ITM2B_MICU2_chr13_22178078_ENST00000382374_ITM2B_chr13_48827944_ENST00000378565_length(transcript)=2060nt_BP=276nt GAGAGTTCCCAAGCGGTAGGCGGCGGCGCCGGGAGAGAAGCGCCGCCTAGCTGCGCTTCCGCAAAGATGGCGGCGGCTGCGGGTAGCTGC GCGCGGGTGGCGGCCTGGGGCGGAAAACTGCGACGGGGGCTCGCTGTCAGCCGACAGGCTGTGCGGAGTCCCGGCCCCTTGGCAGCGGCA GTGGCCGGCGCGGCCCTGGCAGGAGCAGGAGCGGCCTGGCACCACAGCCGCGTCAGTGTTGCGGCGCGGGATGGCAGTTTTACAGTCTCC GCACAGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGT GTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGAT GTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATATTAAAATCTTTGAAGAAGAAGAAGTT GAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTA GATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAAACCTACTGGAGTTACTTATTAACATC AAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTC TTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAAT TGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAAT TAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTAC TATCTTTTCATCTCATTAATTCAATTAAAACCATTACCTTAAAATTTTTTTCTTTCGAAGTGTGGTGTCTTTTATATTTGAATTAGTAAC TGTATGAAGTCATAGATAATAGTACATGTCACCTTAGGTAGTAGGAAGAATTACAATTTCTTTAAATCATTTATCTGGATTTTTATGTTT TATTAGCATTTTCAAGAAGACGGATTATCTAGAGAATAATCATATATATGCATACGTAAAAATGGACCACAGTGACTTATTTGTAGTTGT TAGTTGCCCTGCTACCTAGTTTGTTAGTGCATTTGAGCACACATTTTAATTTTCCTCTAATTAAAATGTGCAGTATTTTCAGTGTCAAAT ATATTTAACTATTTAGAGAATGATTTCCACCTTTATGTTTTAATATCCTAGGCATCTGCTGTAATAATATTTTAGAAAATGTTTGGAATT TAAGAAATAACTTGTGTTACTAATTTGTATAACCCATATCTGTGCAATGGAATATAAATATCACAAAGTTGTTTAACTAGACTGCGTGTT GTTTTTCCCGTATAATAAAACCAAAGAATAGTTTGGTTCTTCAAATCTTAAGAGAATCCACATAAAAGAAGAAACTATTTTTTAAAAATT CACTTCTATATATACAATGAGTAAAATCACAGATTTTTTCTTTAAATAAAAATAAGTCATTTTAATAACTAAACCAGATTCTTTGTGGAT ACTATTAAAGTAACATTTAAGCCTCAACCTTGAATGATGTTGTTTAATATAAAATGCTTTTATTTTTGATGGAAAGGCAATCAAAGCCTA AAGTTTCCAAGGAACGTAAAATAACTGTGCTTCTCTGAGAATGCCCGCCTCACAAGTGGAACATTTTGAGTTAATAATGATGATTTTTAT >53582_53582_2_MICU2-ITM2B_MICU2_chr13_22178078_ENST00000382374_ITM2B_chr13_48827944_ENST00000378565_length(amino acids)=297AA_BP=70 MAAAAGSCARVAAWGGKLRRGLAVSRQAVRSPGPLAAAVAGAALAGAGAAWHHSRVSVAARDGSFTVSAQDPDDVVPVGQRRAWCWCMCF GLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDF NKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MICU2-ITM2B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MICU2-ITM2B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MICU2-ITM2B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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