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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:MICU3-TGFBR3 (FusionGDB2 ID:53586) |
Fusion Gene Summary for MICU3-TGFBR3 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MICU3-TGFBR3 | Fusion gene ID: 53586 | Hgene | Tgene | Gene symbol | MICU3 | TGFBR3 | Gene ID | 286097 | 7049 |
Gene name | mitochondrial calcium uptake family member 3 | transforming growth factor beta receptor 3 | |
Synonyms | EFHA2 | BGCAN|betaglycan | |
Cytomap | 8p22 | 1p22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | calcium uptake protein 3, mitochondrialEF hand domain family A2EF-hand domain family, member A2EF-hand domain-containing family member A2mitochondrial uptake family, member 3 | transforming growth factor beta receptor type 3TGF-beta receptor type 3TGF-beta receptor type IIITGFR-3betaglycan proteoglycantransforming growth factor beta receptor III | |
Modification date | 20200315 | 20200313 | |
UniProtAcc | Q86XE3 | . | |
Ensembl transtripts involved in fusion gene | ENST00000318063, ENST00000519866, | ENST00000468996, ENST00000212355, ENST00000370399, ENST00000525962, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 10 X 9 X 9=810 |
# samples | 2 | 10 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(10/810*10)=-3.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MICU3 [Title/Abstract] AND TGFBR3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | MICU3(16885169)-TGFBR3(92200516), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TGFBR3 | GO:0001837 | epithelial to mesenchymal transition | 18184661 |
Tgene | TGFBR3 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 12958365 |
Tgene | TGFBR3 | GO:0030509 | BMP signaling pathway | 18184661 |
Tgene | TGFBR3 | GO:0032354 | response to follicle-stimulating hormone | 14557487 |
Tgene | TGFBR3 | GO:0034695 | response to prostaglandin E | 14557487 |
Tgene | TGFBR3 | GO:0034699 | response to luteinizing hormone | 14557487 |
Tgene | TGFBR3 | GO:0051271 | negative regulation of cellular component movement | 17999987 |
Tgene | TGFBR3 | GO:0060317 | cardiac epithelial to mesenchymal transition | 18184661 |
Fusion gene breakpoints across MICU3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across TGFBR3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SKCM | TCGA-EE-A29L-06A | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
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Fusion Gene ORF analysis for MICU3-TGFBR3 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000318063 | ENST00000468996 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
In-frame | ENST00000318063 | ENST00000212355 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
In-frame | ENST00000318063 | ENST00000370399 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
In-frame | ENST00000318063 | ENST00000525962 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
intron-3CDS | ENST00000519866 | ENST00000212355 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
intron-3CDS | ENST00000519866 | ENST00000370399 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
intron-3CDS | ENST00000519866 | ENST00000525962 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
intron-5UTR | ENST00000519866 | ENST00000468996 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000318063 | MICU3 | chr8 | 16885169 | + | ENST00000212355 | TGFBR3 | chr1 | 92200516 | - | 5989 | 423 | 21 | 2594 | 857 |
ENST00000318063 | MICU3 | chr8 | 16885169 | + | ENST00000370399 | TGFBR3 | chr1 | 92200516 | - | 3905 | 423 | 21 | 2591 | 856 |
ENST00000318063 | MICU3 | chr8 | 16885169 | + | ENST00000525962 | TGFBR3 | chr1 | 92200516 | - | 3904 | 423 | 21 | 2594 | 857 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000318063 | ENST00000212355 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - | 8.56E-05 | 0.9999144 |
ENST00000318063 | ENST00000370399 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - | 0.000290482 | 0.99970955 |
ENST00000318063 | ENST00000525962 | MICU3 | chr8 | 16885169 | + | TGFBR3 | chr1 | 92200516 | - | 0.000281443 | 0.9997185 |
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Fusion Genomic Features for MICU3-TGFBR3 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MICU3-TGFBR3 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:16885169/chr1:92200516) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MICU3 | . |
FUNCTION: May play a role in mitochondrial calcium uptake. {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MICU3 | chr8:16885169 | chr1:92200516 | ENST00000318063 | + | 1 | 15 | 59_63 | 127 | 1175.6666666666667 | Compositional bias | Note=Poly-Arg |
Hgene | MICU3 | chr8:16885169 | chr1:92200516 | ENST00000318063 | + | 1 | 15 | 70_73 | 127 | 1175.6666666666667 | Compositional bias | Note=Poly-Ala |
Hgene | MICU3 | chr8:16885169 | chr1:92200516 | ENST00000318063 | + | 1 | 15 | 67_83 | 127 | 1175.6666666666667 | Transmembrane | Helical |
Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000212355 | 3 | 17 | 455_730 | 128 | 852.0 | Domain | ZP | |
Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000370399 | 4 | 18 | 455_730 | 128 | 851.0 | Domain | ZP | |
Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000525962 | 2 | 16 | 455_730 | 128 | 852.0 | Domain | ZP | |
Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000212355 | 3 | 17 | 810_851 | 128 | 852.0 | Topological domain | Cytoplasmic | |
Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000370399 | 4 | 18 | 810_851 | 128 | 851.0 | Topological domain | Cytoplasmic | |
Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000525962 | 2 | 16 | 810_851 | 128 | 852.0 | Topological domain | Cytoplasmic | |
Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000212355 | 3 | 17 | 788_809 | 128 | 852.0 | Transmembrane | Helical | |
Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000370399 | 4 | 18 | 788_809 | 128 | 851.0 | Transmembrane | Helical | |
Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000525962 | 2 | 16 | 788_809 | 128 | 852.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MICU3 | chr8:16885169 | chr1:92200516 | ENST00000318063 | + | 1 | 15 | 245_256 | 127 | 1175.6666666666667 | Calcium binding | 1 |
Hgene | MICU3 | chr8:16885169 | chr1:92200516 | ENST00000318063 | + | 1 | 15 | 483_494 | 127 | 1175.6666666666667 | Calcium binding | 2 |
Hgene | MICU3 | chr8:16885169 | chr1:92200516 | ENST00000318063 | + | 1 | 15 | 232_267 | 127 | 1175.6666666666667 | Domain | EF-hand 1 |
Hgene | MICU3 | chr8:16885169 | chr1:92200516 | ENST00000318063 | + | 1 | 15 | 401_436 | 127 | 1175.6666666666667 | Domain | EF-hand 2 |
Hgene | MICU3 | chr8:16885169 | chr1:92200516 | ENST00000318063 | + | 1 | 15 | 470_505 | 127 | 1175.6666666666667 | Domain | EF-hand 3 |
Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000212355 | 3 | 17 | 21_787 | 128 | 852.0 | Topological domain | Extracellular | |
Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000370399 | 4 | 18 | 21_787 | 128 | 851.0 | Topological domain | Extracellular | |
Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000525962 | 2 | 16 | 21_787 | 128 | 852.0 | Topological domain | Extracellular |
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Fusion Gene Sequence for MICU3-TGFBR3 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>53586_53586_1_MICU3-TGFBR3_MICU3_chr8_16885169_ENST00000318063_TGFBR3_chr1_92200516_ENST00000212355_length(transcript)=5989nt_BP=423nt GTTCTCTGCCCCCTCCCAGCTCTGGTGTGGGCGGCCTCCGCTATGGCTGCGCTGCGAAGGCTCTTGTGGCCGCCACCCCGGGTGTCTCCT CCACTCTGCGCTCACCAGCCCCTCCTTGGGCCGTGGGGGCGGCCTGCGGTGACCACCCTGGGCCTTCCTGGCCGGCCCTTCTCCTCCCGA GAGGATGAGGAGAGGGCTGTGGCGGAGGCGGCATGGAGGCGGCGGCGGCGCTGGGGGGAGCTGAGCGTGGCGGCGGCGGCCGGCGGGGGG CTGGTCGGCCTGGTATGCTACCAGCTGTACGGGGACCCCAGGGCCGGCTCGCCGGCGACCGGGCGACCCTCAAAGAGCGCGGCCACGGAG CCCGAGGACCCGCCCCGCGGCCGGGGGATGCTGCCCATCCCAGTGGCGGCTGCCAAGGAGACGGTGTCTGAGGGTTCTGTGGTCCAGTTT TCATCAGCAAACTTCTCCTTGACAGCAGAAACAGAAGAAAGGAACTTCCCCCATGGAAATGAACATCTGTTAAATTGGGCCCGAAAAGAG TATGGAGCAGTTACTTCATTCACCGAACTCAAGATAGCAAGAAACATTTATATTAAAGTGGGGGAAGATCAAGTGTTCCCTCCAAAGTGC AACATAGGGAAGAATTTTCTCTCACTCAATTACCTTGCTGAGTACCTTCAACCCAAAGCAGCAGAAGGGTGTGTGATGTCCAGCCAGCCC CAGAATGAGGAAGTACACATCATCGAGCTAATCACCCCCAACTCTAACCCCTACAGTGCTTTCCAGGTGGATATAACAATTGATATAAGA CCTTCTCAAGAGGATCTTGAAGTGGTCAAAAATCTCATCCTGATCTTGAAGTGCAAAAAGTCTGTCAACTGGGTGATCAAATCTTTTGAT GTTAAGGGAAGCCTGAAAATTATTGCTCCTAACAGTATTGGCTTTGGAAAAGAGAGTGAAAGATCTATGACAATGACCAAATCAATAAGA GATGACATTCCTTCAACCCAAGGGAATCTGGTGAAGTGGGCTTTGGACAATGGCTATAGTCCAATAACTTCATACACAATGGCTCCTGTG GCTAATAGATTTCATCTTCGGCTTGAAAATAATGCAGAGGAGATGGGAGATGAGGAAGTCCACACTATTCCTCCTGAGCTACGGATCCTG CTGGACCCTGGTGCCCTGCCTGCCCTGCAGAACCCGCCCATCCGGGGAGGGGAAGGCCAAAATGGAGGCCTTCCGTTTCCTTTCCCAGAT ATTTCCAGGAGAGTCTGGAATGAAGAGGGAGAAGATGGGCTCCCTCGGCCAAAGGACCCTGTCATTCCCAGCATACAACTGTTTCCTGGT CTCAGAGAGCCAGAAGAGGTGCAAGGGAGCGTGGATATTGCCCTGTCTGTCAAATGTGACAATGAGAAGATGATCGTGGCTGTAGAAAAA GATTCTTTTCAGGCCAGTGGCTACTCGGGGATGGACGTCACCCTGTTGGATCCTACCTGCAAGGCCAAGATGAATGGCACACACTTTGTT TTGGAGTCTCCTCTGAATGGCTGCGGTACTCGGCCCCGGTGGTCAGCCCTTGATGGTGTGGTCTACTATAACTCCATTGTGATACAGGTT CCAGCCCTTGGGGACAGTAGTGGTTGGCCAGATGGTTATGAAGATCTGGAGTCAGGTGATAATGGATTTCCGGGAGATATGGATGAAGGA GATGCTTCCCTGTTCACCCGACCTGAAATCGTGGTGTTTAATTGCAGCCTTCAGCAGGTGAGGAACCCCAGCAGCTTCCAGGAACAGCCC CACGGAAACATCACCTTCAACATGGAGCTATACAACACTGACCTCTTTTTGGTGCCCTCCCAGGGCGTCTTCTCTGTGCCAGAGAATGGA CACGTTTATGTTGAGGTATCTGTTACTAAGGCTGAACAAGAACTGGGATTTGCCATCCAAACGTGCTTTATCTCTCCATATTCGAACCCT GATAGGATGTCTCATTACACCATTATTGAGAATATTTGTCCTAAAGATGAATCTGTGAAATTCTACAGTCCCAAGAGAGTGCACTTTCCT ATCCCGCAAGCTGACATGGATAAGAAGCGATTCAGCTTTGTCTTCAAGCCTGTCTTCAACACCTCACTGCTCTTTCTACAGTGTGAGCTG ACGCTGTGTACGAAGATGGAGAAGCACCCCCAGAAGTTGCCTAAGTGTGTGCCTCCTGACGAAGCCTGCACCTCGCTGGACGCCTCGATA ATCTGGGCCATGATGCAGAATAAGAAGACGTTCACTAAGCCCCTTGCTGTGATCCACCATGAAGCAGAATCTAAAGAAAAAGGTCCAAGC ATGAAGGAACCAAATCCAATTTCTCCACCAATTTTCCATGGTCTGGACACCCTAACCGTGATGGGCATTGCGTTTGCAGCCTTTGTGATC GGAGCACTCCTGACGGGGGCCTTGTGGTACATCTATTCTCACACAGGGGAGACAGCAGGAAGGCAGCAAGTCCCCACCTCCCCGCCAGCC TCGGAAAACAGCAGTGCTGCCCACAGCATCGGCAGCACGCAGAGCACGCCTTGCTCCAGCAGCAGCACGGCCTAGCCCAACCCAGCCCAA CCCGGCCCAACCCAGCCCAGCCCAGCTCAGCTCAGCTACTGCCAAGGGCAGGACCAATGGCTGAGCCTCGTGTCCAGACTCAGAGGGCTG GATTTTGGTTCCCTTGTAAAGACAGAGTGAATTTCAGTATAAAGATCACCCGTTGTATTCACCCCACACCCAGGGCTAGTATAAACATGA CCCTGGGCTTCTGTACCACACTAGAATTCATGTGAGAAAGCTAAAATGGTGGTCTTCTCCACCAGCCCCTCACAGGCTTGGGGGTTTTCA ATGTGAAACACATGCCAGTTTTTAAAATGCTGCTTTGTCCAGGTGAGAACATCCATAATTTGGGGCCCTGAGTTTTACCCAGACTCAAGG AGTTGGTAAAGGGTTAATAGCCAGATAGTAGAACCAGTGAGGAGATGCGGCCAAAGATTCTTTATATCTGAACCAAGATGTAAAACAAGA AATGCTTTGAGGCTTTCTAAGCGATCCTCCTGTCTAATTTGCACCTTTGTCTGGATGCACACTTCTGACCTTGCTGCCACAACCTGTGGG GTCTGATGTGTCCCTTGATGGGTGCTGCCCTCAGGGACTGCACCCTGACAAGTGTTAAGGCAACATTCCTTTCTTGTGCCCTGGGCCAAA ACCAATGCTGATGACCTTATCAGCTTCCTGTTTCTTCCCATACTTGCATACACCACTGCAAAATGTCTTAATGCAAATTTTGTATTTCTT ACAGGCCTACAGAAATTGAAAATGACCAAAATCAGGAACCACAGATTTGTGCCCATTCCTAATATTTTGTTCTGCAAATTAATGTATAAT TTGAGGTGAAATTCAGTTATAAAGTCAAGGACGAATTTGCACAGTGATATATTTCTATGTGTATGCAAGTACAAGTATATAATATGTCAC CTGGCACATTCATTTTCTCAGTTGAAGAAGAGAAAATTTGAAAATGTCCTTATGCTTTTAGAGTTGCAACTTAAGTATATTTGGTAGGGT GAGTGTTTCCACTCAAAATATGTCAACTTAAAAAAAAATAGGCCCTTTCATAAAAACCAAACTGTAGCAAGATGCAAATGCATGGCAAAT CCTGTCGGTCTCCAGTTGGTTATCTGAATAGTGTCACCAATTCCACCAAGACAGTGCTGAGATTGGAAAAGGGCACTCATTTGGATTGCC TTACTTCTCTTGCCTTAAATATATCCCATATATTTAATATGTCAAAAAGGGCTTGAGGTGAATTTCATTAAATGGAATAATATGATGCCA CTTTGCAGCTAAAATAAGCTCAGTGATACCTCCTTGTTAAAAAAAAAAAAAAAAAAAAAGAATGCCAGGGGGGAATTATCATGCTAAATT ATTTTACTGCTGAAGATAGCTTCATTGCAAATTATTCTTTTTCCAGAATTTCCCCCAAACAACTTAGAATTCCATAAGTAGAACAAGATA GATTCTACCCCCAAAATATTCATAAGCAAATCCCACTGCCCTTAAAATAAGGAAGTTATGCCTGGTTGTCTGTGAATGGAACCTCAGTAG GTAATCCTGATGAAGCTTAAAACCTTAGGGCAGTGTCTACATGGGAAACAAGTATGTGGAAATTGACAATCATTTTTACCAAATCGTTGA GTAATAATATGACTTACCTGATAGATATACACATTCAATAAGGAACATTTTTTTTTTTCAATAAGGAACATTTTAACTAAAACATTACTT TAGGGCTGAGATTTCCAGGCTATCTACATTGATCTACTGAAAAATTTCTAGATTTCCATATACAAACGAAGAAGACATGAGTTTAGAGAA TTTTTTTCCTTTAATTTTTTTTTAACAGAAGGGTATCAGAGTGGAGGACCTAGATTACGCTACCTGTGTTTGAAAATATTGCGCTTTGCC TAACCTTCGGTGGAATGTATTGTTTCAGCATATTCTATGTATAAAAAAGTTTAAAGATGTCTTCAAAGAAGACTAGAGTCTTTAAGTCAC TTATAGCTATATTTTACTACAAAATTTGTGTATAAAGATATATTTAAGTGTTTTAGATAAATTTAAGTTACTCCATATGAAATGTTTAAT TTCAGCTACTGTGAATTCTTTCGATCAGTCCTTTGCTTTTTTAAAAAATCTTTTCCATCGTGTTAAAAAGAAAATTAGCTATTAGGAGAT ATTAAAAGATTGATGTCTTAGAAGGACAGGGTTAAAACCTTCTGTAATATATTTAAATATATATTTTTAAGAGAGATGCTACATTGCCAA TGATTTTATAAATAATTTAAAATTAATTTACAAATTTATAGATGCAAACCAAAAGATCTTTTTAAAAGAGAGAGAGAGGAAAAAAATCAC CTTTTATTTGTTTGGGTCTCATTGTCAGAATTATTATTCAGATCAAGAAATCTGTGTCGATAAAACCTAATCTCATATTGGAGAGTGAAT GTCGTTAAGTATTTCTGAAATGTTTCTAAAAAATGAACATGAAAAAAATAAGGTATTTTCTCCCTAGCTTCTCATTACAGTATTTCTAAT TGCTTCACACTTTACAGTTTTAATACAAAGTACAAGCTCTACTTTTATAACGTGTACTACAAGTTTCTTTAAAAGTATTGTTGTATTTCA GCTGAACTCTTGTATCTGCAGTCTTTTGTTATTTCTGCAGGCTACACCCTTAATTTGCAGAGGCCATTTTGTTGTTTGTTTGATGCTGAA GCTGTTGTTAAAATGCCCCAAACTCCAAGGCAGATTGTCTGTATAATACGCTATAGCTTTTCACCATGTGGTGTTTACCAGCTGTTACTC TGTATTTTAAAAAGCCAGAGATTTCTTCTGTCTAAACTGTTTCTATAGCATTTTCTAAACAAAAAAAATGGTTTTTTTCTTTGCCTTGTA ATAAGATTGTAAATCCATTTCCTGCTTGTGTTCTTAGTGGGCATGATTGTGAGTGTGTGTGGGGTGCTCACACGCGTGCCAGTCTTTTTG TACTGTAACTACCTCATGGTTTGAATGATGATTGTACTGCTGGTTGTGTTAACAGAGCACATTTTGTTGGGTGAGTCCTATGTGATTTTT TTCATGTTTGTTTTATCTGGGGGTTGTTCATGAAACTGACAGATGTTTTTCTAAAAAGGACTATTATCAGTTTCCAAATACAATACTTCT CTCTTCTGGTTTTTCCTGAATGAGCCTGATTTTGTTGCTGGTTTTCATCATCTATGAGGGTAAAACGAGTACCCTTAAAATCCCTGTGGC CAGTTTGAACACCCCTGTTGTATTCTTTTCTCTGTTCAGTGTGTCAGCTATTTTGTGAAGATGCTTAGATGTATAGTTTTGATAACCACA >53586_53586_1_MICU3-TGFBR3_MICU3_chr8_16885169_ENST00000318063_TGFBR3_chr1_92200516_ENST00000212355_length(amino acids)=857AA_BP=134 MVWAASAMAALRRLLWPPPRVSPPLCAHQPLLGPWGRPAVTTLGLPGRPFSSREDEERAVAEAAWRRRRRWGELSVAAAAGGGLVGLVCY QLYGDPRAGSPATGRPSKSAATEPEDPPRGRGMLPIPVAAAKETVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSF TELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLE VVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLR LENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEV QGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSS GWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVS VTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKME KHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGA -------------------------------------------------------------- >53586_53586_2_MICU3-TGFBR3_MICU3_chr8_16885169_ENST00000318063_TGFBR3_chr1_92200516_ENST00000370399_length(transcript)=3905nt_BP=423nt GTTCTCTGCCCCCTCCCAGCTCTGGTGTGGGCGGCCTCCGCTATGGCTGCGCTGCGAAGGCTCTTGTGGCCGCCACCCCGGGTGTCTCCT CCACTCTGCGCTCACCAGCCCCTCCTTGGGCCGTGGGGGCGGCCTGCGGTGACCACCCTGGGCCTTCCTGGCCGGCCCTTCTCCTCCCGA GAGGATGAGGAGAGGGCTGTGGCGGAGGCGGCATGGAGGCGGCGGCGGCGCTGGGGGGAGCTGAGCGTGGCGGCGGCGGCCGGCGGGGGG CTGGTCGGCCTGGTATGCTACCAGCTGTACGGGGACCCCAGGGCCGGCTCGCCGGCGACCGGGCGACCCTCAAAGAGCGCGGCCACGGAG CCCGAGGACCCGCCCCGCGGCCGGGGGATGCTGCCCATCCCAGTGGCGGCTGCCAAGGAGACGGTGTCTGAGGGTTCTGTGGTCCAGTTT TCATCAGCAAACTTCTCCTTGACAGCAGAAACAGAAGAAAGGAACTTCCCCCATGGAAATGAACATCTGTTAAATTGGGCCCGAAAAGAG TATGGAGCAGTTACTTCATTCACCGAACTCAAGATAGCAAGAAACATTTATATTAAAGTGGGGGAAGATCAAGTGTTCCCTCCAAAGTGC AACATAGGGAAGAATTTTCTCTCACTCAATTACCTTGCTGAGTACCTTCAACCCAAAGCAGCAGAAGGGTGTGTGATGTCCAGCCAGCCC CAGAATGAGGAAGTACACATCATCGAGCTAATCACCCCCAACTCTAACCCCTACAGTGCTTTCCAGGTGGATATAACAATTGATATAAGA CCTTCTCAAGAGGATCTTGAAGTGGTCAAAAATCTCATCCTGATCTTGAAGTGCAAAAAGTCTGTCAACTGGGTGATCAAATCTTTTGAT GTTAAGGGAAGCCTGAAAATTATTGCTCCTAACAGTATTGGCTTTGGAAAAGAGAGTGAAAGATCTATGACAATGACCAAATCAATAAGA GATGACATTCCTTCAACCCAAGGGAATCTGGTGAAGTGGGCTTTGGACAATGGCTATAGTCCAATAACTTCATACACAATGGCTCCTGTG GCTAATAGATTTCATCTTCGGCTTGAAAATAATGAGGAGATGGGAGATGAGGAAGTCCACACTATTCCTCCTGAGCTACGGATCCTGCTG GACCCTGGTGCCCTGCCTGCCCTGCAGAACCCGCCCATCCGGGGAGGGGAAGGCCAAAATGGAGGCCTTCCGTTTCCTTTCCCAGATATT TCCAGGAGAGTCTGGAATGAAGAGGGAGAAGATGGGCTCCCTCGGCCAAAGGACCCTGTCATTCCCAGCATACAACTGTTTCCTGGTCTC AGAGAGCCAGAAGAGGTGCAAGGGAGCGTGGATATTGCCCTGTCTGTCAAATGTGACAATGAGAAGATGATCGTGGCTGTAGAAAAAGAT TCTTTTCAGGCCAGTGGCTACTCGGGGATGGACGTCACCCTGTTGGATCCTACCTGCAAGGCCAAGATGAATGGCACACACTTTGTTTTG GAGTCTCCTCTGAATGGCTGCGGTACTCGGCCCCGGTGGTCAGCCCTTGATGGTGTGGTCTACTATAACTCCATTGTGATACAGGTTCCA GCCCTTGGGGACAGTAGTGGTTGGCCAGATGGTTATGAAGATCTGGAGTCAGGTGATAATGGATTTCCGGGAGATATGGATGAAGGAGAT GCTTCCCTGTTCACCCGACCTGAAATCGTGGTGTTTAATTGCAGCCTTCAGCAGGTGAGGAACCCCAGCAGCTTCCAGGAACAGCCCCAC GGAAACATCACCTTCAACATGGAGCTATACAACACTGACCTCTTTTTGGTGCCCTCCCAGGGCGTCTTCTCTGTGCCAGAGAATGGACAC GTTTATGTTGAGGTATCTGTTACTAAGGCTGAACAAGAACTGGGATTTGCCATCCAAACGTGCTTTATCTCTCCATATTCGAACCCTGAT AGGATGTCTCATTACACCATTATTGAGAATATTTGTCCTAAAGATGAATCTGTGAAATTCTACAGTCCCAAGAGAGTGCACTTTCCTATC CCGCAAGCTGACATGGATAAGAAGCGATTCAGCTTTGTCTTCAAGCCTGTCTTCAACACCTCACTGCTCTTTCTACAGTGTGAGCTGACG CTGTGTACGAAGATGGAGAAGCACCCCCAGAAGTTGCCTAAGTGTGTGCCTCCTGACGAAGCCTGCACCTCGCTGGACGCCTCGATAATC TGGGCCATGATGCAGAATAAGAAGACGTTCACTAAGCCCCTTGCTGTGATCCACCATGAAGCAGAATCTAAAGAAAAAGGTCCAAGCATG AAGGAACCAAATCCAATTTCTCCACCAATTTTCCATGGTCTGGACACCCTAACCGTGATGGGCATTGCGTTTGCAGCCTTTGTGATCGGA GCACTCCTGACGGGGGCCTTGTGGTACATCTATTCTCACACAGGGGAGACAGCAGGAAGGCAGCAAGTCCCCACCTCCCCGCCAGCCTCG GAAAACAGCAGTGCTGCCCACAGCATCGGCAGCACGCAGAGCACGCCTTGCTCCAGCAGCAGCACGGCCTAGCCCAACCCAGCCCAACCC GGCCCAACCCAGCCCAGCCCAGCTCAGCTCAGCTACTGCCAAGGGCAGGACCAATGGCTGAGCCTCGTGTCCAGACTCAGAGGGCTGGAT TTTGGTTCCCTTGTAAAGACAGAGTGAATTTCAGTATAAAGATCACCCGTTGTATTCACCCCACACCCAGGGCTAGTATAAACATGACCC TGGGCTTCTGTACCACACTAGAATTCATGTGAGAAAGCTAAAATGGTGGTCTTCTCCACCAGCCCCTCACAGGCTTGGGGGTTTTCAATG TGAAACACATGCCAGTTTTTAAAATGCTGCTTTGTCCAGGTGAGAACATCCATAATTTGGGGCCCTGAGTTTTACCCAGACTCAAGGAGT TGGTAAAGGGTTAATAGCCAGATAGTAGAACCAGTGAGGAGATGCGGCCAAAGATTCTTTATATCTGAACCAAGATGTAAAACAAGAAAT GCTTTGAGGCTTTCTAAGCGATCCTCCTGTCTAATTTGCACCTTTGTCTGGATGCACACTTCTGACCTTGCTGCCACAACCTGTGGGGTC TGATGTGTCCCTTGATGGGTGCTGCCCTCAGGGACTGCACCCTGACAAGTGTTAAGGCAACATTCCTTTCTTGTGCCCTGGGCCAAAACC AATGCTGATGACCTTATCAGCTTCCTGTTTCTTCCCATACTTGCATACACCACTGCAAAATGTCTTAATGCAAATTTTGTATTTCTTACA GGCCTACAGAAATTGAAAATGACCAAAATCAGGAACCACAGATTTGTGCCCATTCCTAATATTTTGTTCTGCAAATTAATGTATAATTTG AGGTGAAATTCAGTTATAAAGTCAAGGACGAATTTGCACAGTGATATATTTCTATGTGTATGCAAGTACAAGTATATAATATGTCACCTG GCACATTCATTTTCTCAGTTGAAGAAGAGAAAATTTGAAAATGTCCTTATGCTTTTAGAGTTGCAACTTAAGTATATTTGGTAGGGTGAG TGTTTCCACTCAAAATATGTCAACTTAAAAAAAAATAGGCCCTTTCATAAAAACCAAACTGTAGCAAGATGCAAATGCATGGCAAATCCT GTCGGTCTCCAGTTGGTTATCTGAATAGTGTCACCAATTCCACCAAGACAGTGCTGAGATTGGAAAAGGGCACTCATTTGGATTGCCTTA CTTCTCTTGCCTTAAATATATCCCATATATTTAATATGTCAAAAAGGGCTTGAGGTGAATTTCATTAAATGGAATAATATGATGCCACTT >53586_53586_2_MICU3-TGFBR3_MICU3_chr8_16885169_ENST00000318063_TGFBR3_chr1_92200516_ENST00000370399_length(amino acids)=856AA_BP=134 MVWAASAMAALRRLLWPPPRVSPPLCAHQPLLGPWGRPAVTTLGLPGRPFSSREDEERAVAEAAWRRRRRWGELSVAAAAGGGLVGLVCY QLYGDPRAGSPATGRPSKSAATEPEDPPRGRGMLPIPVAAAKETVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSF TELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLE VVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLR LENNEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQ GSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSG WPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSV TKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEK HPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGAL -------------------------------------------------------------- >53586_53586_3_MICU3-TGFBR3_MICU3_chr8_16885169_ENST00000318063_TGFBR3_chr1_92200516_ENST00000525962_length(transcript)=3904nt_BP=423nt GTTCTCTGCCCCCTCCCAGCTCTGGTGTGGGCGGCCTCCGCTATGGCTGCGCTGCGAAGGCTCTTGTGGCCGCCACCCCGGGTGTCTCCT CCACTCTGCGCTCACCAGCCCCTCCTTGGGCCGTGGGGGCGGCCTGCGGTGACCACCCTGGGCCTTCCTGGCCGGCCCTTCTCCTCCCGA GAGGATGAGGAGAGGGCTGTGGCGGAGGCGGCATGGAGGCGGCGGCGGCGCTGGGGGGAGCTGAGCGTGGCGGCGGCGGCCGGCGGGGGG CTGGTCGGCCTGGTATGCTACCAGCTGTACGGGGACCCCAGGGCCGGCTCGCCGGCGACCGGGCGACCCTCAAAGAGCGCGGCCACGGAG CCCGAGGACCCGCCCCGCGGCCGGGGGATGCTGCCCATCCCAGTGGCGGCTGCCAAGGAGACGGTGTCTGAGGGTTCTGTGGTCCAGTTT TCATCAGCAAACTTCTCCTTGACAGCAGAAACAGAAGAAAGGAACTTCCCCCATGGAAATGAACATCTGTTAAATTGGGCCCGAAAAGAG TATGGAGCAGTTACTTCATTCACCGAACTCAAGATAGCAAGAAACATTTATATTAAAGTGGGGGAAGATCAAGTGTTCCCTCCAAAGTGC AACATAGGGAAGAATTTTCTCTCACTCAATTACCTTGCTGAGTACCTTCAACCCAAAGCAGCAGAAGGGTGTGTGATGTCCAGCCAGCCC CAGAATGAGGAAGTACACATCATCGAGCTAATCACCCCCAACTCTAACCCCTACAGTGCTTTCCAGGTGGATATAACAATTGATATAAGA CCTTCTCAAGAGGATCTTGAAGTGGTCAAAAATCTCATCCTGATCTTGAAGTGCAAAAAGTCTGTCAACTGGGTGATCAAATCTTTTGAT GTTAAGGGAAGCCTGAAAATTATTGCTCCTAACAGTATTGGCTTTGGAAAAGAGAGTGAAAGATCTATGACAATGACCAAATCAATAAGA GATGACATTCCTTCAACCCAAGGGAATCTGGTGAAGTGGGCTTTGGACAATGGCTATAGTCCAATAACTTCATACACAATGGCTCCTGTG GCTAATAGATTTCATCTTCGGCTTGAAAATAATGCAGAGGAGATGGGAGATGAGGAAGTCCACACTATTCCTCCTGAGCTACGGATCCTG CTGGACCCTGGTGCCCTGCCTGCCCTGCAGAACCCGCCCATCCGGGGAGGGGAAGGCCAAAATGGAGGCCTTCCGTTTCCTTTCCCAGAT ATTTCCAGGAGAGTCTGGAATGAAGAGGGAGAAGATGGGCTCCCTCGGCCAAAGGACCCTGTCATTCCCAGCATACAACTGTTTCCTGGT CTCAGAGAGCCAGAAGAGGTGCAAGGGAGCGTGGATATTGCCCTGTCTGTCAAATGTGACAATGAGAAGATGATCGTGGCTGTAGAAAAA GATTCTTTTCAGGCCAGTGGCTACTCGGGGATGGACGTCACCCTGTTGGATCCTACCTGCAAGGCCAAGATGAATGGCACACACTTTGTT TTGGAGTCTCCTCTGAATGGCTGCGGTACTCGGCCCCGGTGGTCAGCCCTTGATGGTGTGGTCTACTATAACTCCATTGTGATACAGGTT CCAGCCCTTGGGGACAGTAGTGGTTGGCCAGATGGTTATGAAGATCTGGAGTCAGGTGATAATGGATTTCCGGGAGATATGGATGAAGGA GATGCTTCCCTGTTCACCCGACCTGAAATCGTGGTGTTTAATTGCAGCCTTCAGCAGGTGAGGAACCCCAGCAGCTTCCAGGAACAGCCC CACGGAAACATCACCTTCAACATGGAGCTATACAACACTGACCTCTTTTTGGTGCCCTCCCAGGGCGTCTTCTCTGTGCCAGAGAATGGA CACGTTTATGTTGAGGTATCTGTTACTAAGGCTGAACAAGAACTGGGATTTGCCATCCAAACGTGCTTTATCTCTCCATATTCGAACCCT GATAGGATGTCTCATTACACCATTATTGAGAATATTTGTCCTAAAGATGAATCTGTGAAATTCTACAGTCCCAAGAGAGTGCACTTTCCT ATCCCGCAAGCTGACATGGATAAGAAGCGATTCAGCTTTGTCTTCAAGCCTGTCTTCAACACCTCACTGCTCTTTCTACAGTGTGAGCTG ACGCTGTGTACGAAGATGGAGAAGCACCCCCAGAAGTTGCCTAAGTGTGTGCCTCCTGACGAAGCCTGCACCTCGCTGGACGCCTCGATA ATCTGGGCCATGATGCAGAATAAGAAGACGTTCACTAAGCCCCTTGCTGTGATCCACCATGAAGCAGAATCTAAAGAAAAAGGTCCAAGC ATGAAGGAACCAAATCCAATTTCTCCACCAATTTTCCATGGTCTGGACACCCTAACCGTGATGGGCATTGCGTTTGCAGCCTTTGTGATC GGAGCACTCCTGACGGGGGCCTTGTGGTACATCTATTCTCACACAGGGGAGACAGCAGGAAGGCAGCAAGTCCCCACCTCCCCGCCAGCC TCGGAAAACAGCAGTGCTGCCCACAGCATCGGCAGCACGCAGAGCACGCCTTGCTCCAGCAGCAGCACGGCCTAGCCCAACCCAGCCCAA CCCGGCCCAACCCAGCCCAGCCCAGCTCAGCTCAGCTACTGCCAAGGGCAGGACCAATGGCTGAGCCTCGTGTCCAGACTCAGAGGGCTG GATTTTGGTTCCCTTGTAAAGACAGAGTGAATTTCAGTATAAAGATCACCCGTTGTATTCACCCCACACCCAGGGCTAGTATAAACATGA CCCTGGGCTTCTGTACCACACTAGAATTCATGTGAGAAAGCTAAAATGGTGGTCTTCTCCACCAGCCCCTCACAGGCTTGGGGGTTTTCA ATGTGAAACACATGCCAGTTTTTAAAATGCTGCTTTGTCCAGGTGAGAACATCCATAATTTGGGGCCCTGAGTTTTACCCAGACTCAAGG AGTTGGTAAAGGGTTAATAGCCAGATAGTAGAACCAGTGAGGAGATGCGGCCAAAGATTCTTTATATCTGAACCAAGATGTAAAACAAGA AATGCTTTGAGGCTTTCTAAGCGATCCTCCTGTCTAATTTGCACCTTTGTCTGGATGCACACTTCTGACCTTGCTGCCACAACCTGTGGG GTCTGATGTGTCCCTTGATGGGTGCTGCCCTCAGGGACTGCACCCTGACAAGTGTTAAGGCAACATTCCTTTCTTGTGCCCTGGGCCAAA ACCAATGCTGATGACCTTATCAGCTTCCTGTTTCTTCCCATACTTGCATACACCACTGCAAAATGTCTTAATGCAAATTTTGTATTTCTT ACAGGCCTACAGAAATTGAAAATGACCAAAATCAGGAACCACAGATTTGTGCCCATTCCTAATATTTTGTTCTGCAAATTAATGTATAAT TTGAGGTGAAATTCAGTTATAAAGTCAAGGACGAATTTGCACAGTGATATATTTCTATGTGTATGCAAGTACAAGTATATAATATGTCAC CTGGCACATTCATTTTCTCAGTTGAAGAAGAGAAAATTTGAAAATGTCCTTATGCTTTTAGAGTTGCAACTTAAGTATATTTGGTAGGGT GAGTGTTTCCACTCAAAATATGTCAACTTAAAAAAAAATAGGCCCTTTCATAAAAACCAAACTGTAGCAAGATGCAAATGCATGGCAAAT CCTGTCGGTCTCCAGTTGGTTATCTGAATAGTGTCACCAATTCCACCAAGACAGTGCTGAGATTGGAAAAGGGCACTCATTTGGATTGCC TTACTTCTCTTGCCTTAAATATATCCCATATATTTAATATGTCAAAAAGGGCTTGAGGTGAATTTCATTAAATGGAATAATATGATGCCA >53586_53586_3_MICU3-TGFBR3_MICU3_chr8_16885169_ENST00000318063_TGFBR3_chr1_92200516_ENST00000525962_length(amino acids)=857AA_BP=134 MVWAASAMAALRRLLWPPPRVSPPLCAHQPLLGPWGRPAVTTLGLPGRPFSSREDEERAVAEAAWRRRRRWGELSVAAAAGGGLVGLVCY QLYGDPRAGSPATGRPSKSAATEPEDPPRGRGMLPIPVAAAKETVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSF TELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLE VVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLR LENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEV QGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSS GWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVS VTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKME KHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGALLTGA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MICU3-TGFBR3 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000212355 | 3 | 17 | 737_751 | 128.0 | 852.0 | TGF-beta ligand | |
Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000370399 | 4 | 18 | 737_751 | 128.0 | 851.0 | TGF-beta ligand | |
Tgene | TGFBR3 | chr8:16885169 | chr1:92200516 | ENST00000525962 | 2 | 16 | 737_751 | 128.0 | 852.0 | TGF-beta ligand |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MICU3-TGFBR3 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MICU3-TGFBR3 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |