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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MIDN-ABCA7 (FusionGDB2 ID:53600)

Fusion Gene Summary for MIDN-ABCA7

check button Fusion gene summary
Fusion gene informationFusion gene name: MIDN-ABCA7
Fusion gene ID: 53600
HgeneTgene
Gene symbol

MIDN

ABCA7

Gene ID

90007

10347

Gene namemidnolinATP binding cassette subfamily A member 7
Synonyms-ABCA-SSN|ABCX|AD9
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionmidnolinmidbrain nucleolar proteinphospholipid-transporting ATPase ABCA7ATP-binding cassette sub-family A member 7ATP-binding cassette, sub-family A (ABC1), member 7autoantigen SS-Nmacrophage ABC transporter
Modification date2020031320200320
UniProtAcc.

Q8IZY2

Ensembl transtripts involved in fusion geneENST00000300952, ENST00000591446, 
ENST00000533574, ENST00000263094, 
ENST00000433129, ENST00000435683, 
Fusion gene scores* DoF score9 X 7 X 6=3785 X 4 X 4=80
# samples 135
** MAII scorelog2(13/378*10)=-1.53987461119262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MIDN [Title/Abstract] AND ABCA7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMIDN(1251900)-ABCA7(1061781), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneABCA7

GO:0033344

cholesterol efflux

14570867

TgeneABCA7

GO:0033700

phospholipid efflux

14570867

TgeneABCA7

GO:0034380

high-density lipoprotein particle assembly

14570867

TgeneABCA7

GO:0038027

apolipoprotein A-I-mediated signaling pathway

14570867

TgeneABCA7

GO:0045332

phospholipid translocation

24097981


check buttonFusion gene breakpoints across MIDN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCA7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-05-4418-01AMIDNchr19

1251900

+ABCA7chr19

1061781

+


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Fusion Gene ORF analysis for MIDN-ABCA7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000300952ENST00000533574MIDNchr19

1251900

+ABCA7chr19

1061781

+
5CDS-intronENST00000591446ENST00000533574MIDNchr19

1251900

+ABCA7chr19

1061781

+
In-frameENST00000300952ENST00000263094MIDNchr19

1251900

+ABCA7chr19

1061781

+
In-frameENST00000300952ENST00000433129MIDNchr19

1251900

+ABCA7chr19

1061781

+
In-frameENST00000300952ENST00000435683MIDNchr19

1251900

+ABCA7chr19

1061781

+
In-frameENST00000591446ENST00000263094MIDNchr19

1251900

+ABCA7chr19

1061781

+
In-frameENST00000591446ENST00000433129MIDNchr19

1251900

+ABCA7chr19

1061781

+
In-frameENST00000591446ENST00000435683MIDNchr19

1251900

+ABCA7chr19

1061781

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000300952MIDNchr191251900+ENST00000263094ABCA7chr191061781+20218993411876511
ENST00000300952MIDNchr191251900+ENST00000433129ABCA7chr191061781+20218993411876511
ENST00000300952MIDNchr191251900+ENST00000435683ABCA7chr191061781+18778993411876512
ENST00000591446MIDNchr191251900+ENST00000263094ABCA7chr191061781+19157932351770511
ENST00000591446MIDNchr191251900+ENST00000433129ABCA7chr191061781+19157932351770511
ENST00000591446MIDNchr191251900+ENST00000435683ABCA7chr191061781+17717932351770512

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000300952ENST00000263094MIDNchr191251900+ABCA7chr191061781+0.0698524340.9301475
ENST00000300952ENST00000433129MIDNchr191251900+ABCA7chr191061781+0.0698524340.9301475
ENST00000300952ENST00000435683MIDNchr191251900+ABCA7chr191061781+0.0602966440.9397034
ENST00000591446ENST00000263094MIDNchr191251900+ABCA7chr191061781+0.074107270.92589265
ENST00000591446ENST00000433129MIDNchr191251900+ABCA7chr191061781+0.074107270.92589265
ENST00000591446ENST00000435683MIDNchr191251900+ABCA7chr191061781+0.064531840.9354682

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Fusion Genomic Features for MIDN-ABCA7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MIDN-ABCA7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1251900/chr19:1061781)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ABCA7

Q8IZY2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:14592415, PubMed:12917409, PubMed:12925201, PubMed:14570867). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791). {ECO:0000250|UniProtKB:Q91V24, ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:12925201, ECO:0000269|PubMed:14570867, ECO:0000269|PubMed:14592415, ECO:0000269|PubMed:24097981, ECO:0000269|PubMed:26260791}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMIDNchr19:1251900chr19:1061781ENST00000300952+4831_105128469.0DomainUbiquitin-like
HgeneMIDNchr19:1251900chr19:1061781ENST00000591446+3731_105128469.0DomainUbiquitin-like
TgeneABCA7chr19:1251900chr19:1061781ENST0000043568333411793_202516832009.0DomainABC transporter 2
TgeneABCA7chr19:1251900chr19:1061781ENST0000026309439471827_183418212147.0Nucleotide bindingATP 2
TgeneABCA7chr19:1251900chr19:1061781ENST0000043312938461827_183418212147.0Nucleotide bindingATP 2
TgeneABCA7chr19:1251900chr19:1061781ENST0000043568333411827_183416832009.0Nucleotide bindingATP 2
TgeneABCA7chr19:1251900chr19:1061781ENST0000043568333411683_170316832009.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000043568333411729_174916832009.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCA7chr19:1251900chr19:1061781ENST0000026309439471793_202518212147.0DomainABC transporter 2
TgeneABCA7chr19:1251900chr19:1061781ENST000002630943947807_103818212147.0DomainABC transporter 1
TgeneABCA7chr19:1251900chr19:1061781ENST0000043312938461793_202518212147.0DomainABC transporter 2
TgeneABCA7chr19:1251900chr19:1061781ENST000004331293846807_103818212147.0DomainABC transporter 1
TgeneABCA7chr19:1251900chr19:1061781ENST000004356833341807_103816832009.0DomainABC transporter 1
TgeneABCA7chr19:1251900chr19:1061781ENST000002630943947841_84818212147.0Nucleotide bindingATP 1
TgeneABCA7chr19:1251900chr19:1061781ENST000004331293846841_84818212147.0Nucleotide bindingATP 1
TgeneABCA7chr19:1251900chr19:1061781ENST000004356833341841_84816832009.0Nucleotide bindingATP 1
TgeneABCA7chr19:1251900chr19:1061781ENST0000026309439471264_153718212147.0Topological domainExtracellular
TgeneABCA7chr19:1251900chr19:1061781ENST00000263094394743_54918212147.0Topological domainExtracellular
TgeneABCA7chr19:1251900chr19:1061781ENST0000043312938461264_153718212147.0Topological domainExtracellular
TgeneABCA7chr19:1251900chr19:1061781ENST00000433129384643_54918212147.0Topological domainExtracellular
TgeneABCA7chr19:1251900chr19:1061781ENST0000043568333411264_153716832009.0Topological domainExtracellular
TgeneABCA7chr19:1251900chr19:1061781ENST00000435683334143_54916832009.0Topological domainExtracellular
TgeneABCA7chr19:1251900chr19:1061781ENST0000026309439471243_126318212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000026309439471538_155818212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000026309439471584_160418212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000026309439471621_164118212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000026309439471649_166918212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000026309439471683_170318212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000026309439471729_174918212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST00000263094394722_4218212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000002630943947550_57018212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000002630943947593_61318212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000002630943947626_64618212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000002630943947655_67518212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000002630943947687_70718212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000002630943947727_74718212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000002630943947849_86918212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000043312938461243_126318212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000043312938461538_155818212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000043312938461584_160418212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000043312938461621_164118212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000043312938461649_166918212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000043312938461683_170318212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000043312938461729_174918212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST00000433129384622_4218212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000004331293846550_57018212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000004331293846593_61318212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000004331293846626_64618212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000004331293846655_67518212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000004331293846687_70718212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000004331293846727_74718212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000004331293846849_86918212147.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000043568333411243_126316832009.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000043568333411538_155816832009.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000043568333411584_160416832009.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000043568333411621_164116832009.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST0000043568333411649_166916832009.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST00000435683334122_4216832009.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000004356833341550_57016832009.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000004356833341593_61316832009.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000004356833341626_64616832009.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000004356833341655_67516832009.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000004356833341687_70716832009.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000004356833341727_74716832009.0TransmembraneHelical
TgeneABCA7chr19:1251900chr19:1061781ENST000004356833341849_86916832009.0TransmembraneHelical


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Fusion Gene Sequence for MIDN-ABCA7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>53600_53600_1_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000300952_ABCA7_chr19_1061781_ENST00000263094_length(transcript)=2021nt_BP=899nt
GATAAAGGCTGAGGGCCGCGCGCTTGGCCCAGACCGGCCCGGCCAGCGCGCATTCGGCCCCGGACGAAGGTACTCGCAGCACTTGGAGCG
CAGAACCGGCCGCGCCCGATCCTCCGAGCGGCGGCGACGGCTGTTGCTAAGGGAGGGGACGCGCGAGGAAGCGCGACCCGGGCGGCAGAC
GGCACCCAGCGCCACCAGCCGAGCGGCGCCCCCTCCCCAGGACCCTTAACCGCGCCGCGTCCCGGTCGCGCCCGCCGCCCTTTGAAGGAG
AAGCAAGTGCCGTCCCCACCCCCGGAAGGCGCCCCCAGGAGCCGGAGCGACCTCGGAGCGCCACTCGGATTTTGGATTTCGGTCTCGCAT
TCCGCGGCCGGGACTTTCTCGAGGAGGACGCGCGCTGCTCCGCGCCCCCGAGTGCCCGGAGGACCCGGCATCCGGGGAGCCTCTCGCCCC
TGTCCCGGAGGCGCGGCGAGGATTGGCGGCGCCCGCCGCCCCCAGCCCCCCAGCGCGCGCCGGGGATGGAGCCGCAGCCCGGCGGCGCCC
GGAGCTGCCGGCGCGGGGCCCCCGGCGGCGCCTGCGAGCTGGGCCCGGCGGCCGAGGCGGCGCCCATGAGCCTCGCCATCCACAGCACCA
CGGGCACCCGCTACGACCTGGCCGTGCCGCCCGACGAGACGGTGGAGGGGCTGCGCAAGCGGTTGTCCCAGCGCCTCAAAGTGCCCAAGG
AGCGCCTGGCTCTTCTCCACAAAGACACCCGGCTCAGTTCGGGGAAGCTGCAGGAGTTCGGCGTGGGTGATGGCAGCAAGCTGACCTTGG
TACCCACCGTGGAAGCGGGCCTCATGTCTCAGGCCTCAAGGCCGGAACAGTCCGTGATGCAAGCTCTCGAGAGTCTCACGGAGACGCAGT
GTTTTGGGCTGCTGGGTGTGAATGGAGCAGGGAAGACGTCCACGTTTCGCATGGTGACGGGGGACACATTGGCCAGCAGGGGCGAGGCTG
TGCTGGCAGGCCACAGCGTGGCCCGGGAACCCAGTGCTGCGCACCTCAGCATGGGATACTGCCCTCAATCCGATGCCATCTTTGAGCTGC
TGACGGGCCGCGAGCACCTGGAGCTGCTTGCGCGCCTGCGCGGTGTCCCGGAGGCCCAGGTTGCCCAGACCGCTGGCTCGGGCCTGGCGC
GTCTGGGACTCTCATGGTACGCAGACCGGCCTGCAGGCACCTACAGCGGAGGGAACAAACGCAAGCTGGCGACGGCCCTGGCGCTGGTTG
GGGACCCAGCCGTGGTGTTTCTGGACGAGCCGACCACAGGCATGGACCCCAGCGCGCGGCGCTTCCTTTGGAACAGCCTTTTGGCCGTGG
TGCGGGAGGGCCGTTCAGTGATGCTCACCTCCCATAGCATGGAGGAGTGTGAAGCGCTCTGCTCGCGCCTGGCCATCATGGTGAATGGGC
GGTTCCGCTGCCTGGGCAGCCCGCAACATCTCAAGGGCAGATTCGCGGCGGGTCACACACTGACCCTGCGGGTGCCCGCCGCAAGGTCCC
AGCCGGCAGCGGCCTTCGTGGCGGCCGAGTTCCCTGGGGCGGAGCTGCGCGAGGCACATGGAGGCCGCCTGCGCTTCCAGCTGCCGCCGG
GAGGGCGCTGCGCCCTGGCGCGCGTCTTTGGAGAGCTGGCGGTGCACGGCGCAGAGCACGGCGTGGAGGACTTTTCCGTGAGCCAGACGA
TGCTGGAGGAGGTATTCTTGTACTTCTCCAAGGACCAGGGGAAGGACGAGGACACCGAAGAGCAGAAGGAGGCAGGAGTGGGAGTGGACC
CCGCGCCAGGCCTGCAGCACCCCAAACGCGTCAGCCAGTTCCTCGATGACCCTAGCACTGCCGAGACTGTGCTCTGAGCCTCCCTCCCCT
GCGGGGCCGCGGGGAGGCCCTGGGAATGGCAAGGGCAAGGTAGAGTGCCTAGGAGCCCTGGACTCAGGCTGGCAGAGGGGCTGGTGCCCT

>53600_53600_1_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000300952_ABCA7_chr19_1061781_ENST00000263094_length(amino acids)=511AA_BP=24
MDFGLAFRGRDFLEEDARCSAPPSARRTRHPGSLSPLSRRRGEDWRRPPPPAPQRAPGMEPQPGGARSCRRGAPGGACELGPAAEAAPMS
LAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALE
SLTETQCFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQT
AGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRL
AIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED

--------------------------------------------------------------
>53600_53600_2_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000300952_ABCA7_chr19_1061781_ENST00000433129_length(transcript)=2021nt_BP=899nt
GATAAAGGCTGAGGGCCGCGCGCTTGGCCCAGACCGGCCCGGCCAGCGCGCATTCGGCCCCGGACGAAGGTACTCGCAGCACTTGGAGCG
CAGAACCGGCCGCGCCCGATCCTCCGAGCGGCGGCGACGGCTGTTGCTAAGGGAGGGGACGCGCGAGGAAGCGCGACCCGGGCGGCAGAC
GGCACCCAGCGCCACCAGCCGAGCGGCGCCCCCTCCCCAGGACCCTTAACCGCGCCGCGTCCCGGTCGCGCCCGCCGCCCTTTGAAGGAG
AAGCAAGTGCCGTCCCCACCCCCGGAAGGCGCCCCCAGGAGCCGGAGCGACCTCGGAGCGCCACTCGGATTTTGGATTTCGGTCTCGCAT
TCCGCGGCCGGGACTTTCTCGAGGAGGACGCGCGCTGCTCCGCGCCCCCGAGTGCCCGGAGGACCCGGCATCCGGGGAGCCTCTCGCCCC
TGTCCCGGAGGCGCGGCGAGGATTGGCGGCGCCCGCCGCCCCCAGCCCCCCAGCGCGCGCCGGGGATGGAGCCGCAGCCCGGCGGCGCCC
GGAGCTGCCGGCGCGGGGCCCCCGGCGGCGCCTGCGAGCTGGGCCCGGCGGCCGAGGCGGCGCCCATGAGCCTCGCCATCCACAGCACCA
CGGGCACCCGCTACGACCTGGCCGTGCCGCCCGACGAGACGGTGGAGGGGCTGCGCAAGCGGTTGTCCCAGCGCCTCAAAGTGCCCAAGG
AGCGCCTGGCTCTTCTCCACAAAGACACCCGGCTCAGTTCGGGGAAGCTGCAGGAGTTCGGCGTGGGTGATGGCAGCAAGCTGACCTTGG
TACCCACCGTGGAAGCGGGCCTCATGTCTCAGGCCTCAAGGCCGGAACAGTCCGTGATGCAAGCTCTCGAGAGTCTCACGGAGACGCAGT
GTTTTGGGCTGCTGGGTGTGAATGGAGCAGGGAAGACGTCCACGTTTCGCATGGTGACGGGGGACACATTGGCCAGCAGGGGCGAGGCTG
TGCTGGCAGGCCACAGCGTGGCCCGGGAACCCAGTGCTGCGCACCTCAGCATGGGATACTGCCCTCAATCCGATGCCATCTTTGAGCTGC
TGACGGGCCGCGAGCACCTGGAGCTGCTTGCGCGCCTGCGCGGTGTCCCGGAGGCCCAGGTTGCCCAGACCGCTGGCTCGGGCCTGGCGC
GTCTGGGACTCTCATGGTACGCAGACCGGCCTGCAGGCACCTACAGCGGAGGGAACAAACGCAAGCTGGCGACGGCCCTGGCGCTGGTTG
GGGACCCAGCCGTGGTGTTTCTGGACGAGCCGACCACAGGCATGGACCCCAGCGCGCGGCGCTTCCTTTGGAACAGCCTTTTGGCCGTGG
TGCGGGAGGGCCGTTCAGTGATGCTCACCTCCCATAGCATGGAGGAGTGTGAAGCGCTCTGCTCGCGCCTGGCCATCATGGTGAATGGGC
GGTTCCGCTGCCTGGGCAGCCCGCAACATCTCAAGGGCAGATTCGCGGCGGGTCACACACTGACCCTGCGGGTGCCCGCCGCAAGGTCCC
AGCCGGCAGCGGCCTTCGTGGCGGCCGAGTTCCCTGGGGCGGAGCTGCGCGAGGCACATGGAGGCCGCCTGCGCTTCCAGCTGCCGCCGG
GAGGGCGCTGCGCCCTGGCGCGCGTCTTTGGAGAGCTGGCGGTGCACGGCGCAGAGCACGGCGTGGAGGACTTTTCCGTGAGCCAGACGA
TGCTGGAGGAGGTATTCTTGTACTTCTCCAAGGACCAGGGGAAGGACGAGGACACCGAAGAGCAGAAGGAGGCAGGAGTGGGAGTGGACC
CCGCGCCAGGCCTGCAGCACCCCAAACGCGTCAGCCAGTTCCTCGATGACCCTAGCACTGCCGAGACTGTGCTCTGAGCCTCCCTCCCCT
GCGGGGCCGCGGGGAGGCCCTGGGAATGGCAAGGGCAAGGTAGAGTGCCTAGGAGCCCTGGACTCAGGCTGGCAGAGGGGCTGGTGCCCT

>53600_53600_2_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000300952_ABCA7_chr19_1061781_ENST00000433129_length(amino acids)=511AA_BP=24
MDFGLAFRGRDFLEEDARCSAPPSARRTRHPGSLSPLSRRRGEDWRRPPPPAPQRAPGMEPQPGGARSCRRGAPGGACELGPAAEAAPMS
LAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALE
SLTETQCFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQT
AGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRL
AIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED

--------------------------------------------------------------
>53600_53600_3_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000300952_ABCA7_chr19_1061781_ENST00000435683_length(transcript)=1877nt_BP=899nt
GATAAAGGCTGAGGGCCGCGCGCTTGGCCCAGACCGGCCCGGCCAGCGCGCATTCGGCCCCGGACGAAGGTACTCGCAGCACTTGGAGCG
CAGAACCGGCCGCGCCCGATCCTCCGAGCGGCGGCGACGGCTGTTGCTAAGGGAGGGGACGCGCGAGGAAGCGCGACCCGGGCGGCAGAC
GGCACCCAGCGCCACCAGCCGAGCGGCGCCCCCTCCCCAGGACCCTTAACCGCGCCGCGTCCCGGTCGCGCCCGCCGCCCTTTGAAGGAG
AAGCAAGTGCCGTCCCCACCCCCGGAAGGCGCCCCCAGGAGCCGGAGCGACCTCGGAGCGCCACTCGGATTTTGGATTTCGGTCTCGCAT
TCCGCGGCCGGGACTTTCTCGAGGAGGACGCGCGCTGCTCCGCGCCCCCGAGTGCCCGGAGGACCCGGCATCCGGGGAGCCTCTCGCCCC
TGTCCCGGAGGCGCGGCGAGGATTGGCGGCGCCCGCCGCCCCCAGCCCCCCAGCGCGCGCCGGGGATGGAGCCGCAGCCCGGCGGCGCCC
GGAGCTGCCGGCGCGGGGCCCCCGGCGGCGCCTGCGAGCTGGGCCCGGCGGCCGAGGCGGCGCCCATGAGCCTCGCCATCCACAGCACCA
CGGGCACCCGCTACGACCTGGCCGTGCCGCCCGACGAGACGGTGGAGGGGCTGCGCAAGCGGTTGTCCCAGCGCCTCAAAGTGCCCAAGG
AGCGCCTGGCTCTTCTCCACAAAGACACCCGGCTCAGTTCGGGGAAGCTGCAGGAGTTCGGCGTGGGTGATGGCAGCAAGCTGACCTTGG
TACCCACCGTGGAAGCGGGCCTCATGTCTCAGGCCTCAAGGCCGGAACAGTCCGTGATGCAAGCTCTCGAGAGTCTCACGGAGACGCAGT
GTTTTGGGCTGCTGGGTGTGAATGGAGCAGGGAAGACGTCCACGTTTCGCATGGTGACGGGGGACACATTGGCCAGCAGGGGCGAGGCTG
TGCTGGCAGGCCACAGCGTGGCCCGGGAACCCAGTGCTGCGCACCTCAGCATGGGATACTGCCCTCAATCCGATGCCATCTTTGAGCTGC
TGACGGGCCGCGAGCACCTGGAGCTGCTTGCGCGCCTGCGCGGTGTCCCGGAGGCCCAGGTTGCCCAGACCGCTGGCTCGGGCCTGGCGC
GTCTGGGACTCTCATGGTACGCAGACCGGCCTGCAGGCACCTACAGCGGAGGGAACAAACGCAAGCTGGCGACGGCCCTGGCGCTGGTTG
GGGACCCAGCCGTGGTGTTTCTGGACGAGCCGACCACAGGCATGGACCCCAGCGCGCGGCGCTTCCTTTGGAACAGCCTTTTGGCCGTGG
TGCGGGAGGGCCGTTCAGTGATGCTCACCTCCCATAGCATGGAGGAGTGTGAAGCGCTCTGCTCGCGCCTGGCCATCATGGTGAATGGGC
GGTTCCGCTGCCTGGGCAGCCCGCAACATCTCAAGGGCAGATTCGCGGCGGGTCACACACTGACCCTGCGGGTGCCCGCCGCAAGGTCCC
AGCCGGCAGCGGCCTTCGTGGCGGCCGAGTTCCCTGGGGCGGAGCTGCGCGAGGCACATGGAGGCCGCCTGCGCTTCCAGCTGCCGCCGG
GAGGGCGCTGCGCCCTGGCGCGCGTCTTTGGAGAGCTGGCGGTGCACGGCGCAGAGCACGGCGTGGAGGACTTTTCCGTGAGCCAGACGA
TGCTGGAGGAGGTATTCTTGTACTTCTCCAAGGACCAGGGGAAGGACGAGGACACCGAAGAGCAGAAGGAGGCAGGAGTGGGAGTGGACC

>53600_53600_3_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000300952_ABCA7_chr19_1061781_ENST00000435683_length(amino acids)=512AA_BP=24
MDFGLAFRGRDFLEEDARCSAPPSARRTRHPGSLSPLSRRRGEDWRRPPPPAPQRAPGMEPQPGGARSCRRGAPGGACELGPAAEAAPMS
LAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALE
SLTETQCFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQT
AGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRL
AIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED

--------------------------------------------------------------
>53600_53600_4_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000591446_ABCA7_chr19_1061781_ENST00000263094_length(transcript)=1915nt_BP=793nt
AGATCCTCCGAGCGGCGGCGACGGCTGTTGCTAAGGGAGGGGACGCGCGAGGAAGCGCGACCCGGGCGGCAGACGGCACCCAGCGCCACC
AGCCGAGCGGCGCCCCCTCCCCAGGACCCTTAACCGCGCCGCGTCCCGGTCGCGCCCGCCGCCCTTTGAAGGAGAAGCAAGTGCCGTCCC
CACCCCCGGAAGGCGCCCCCAGGAGCCGGAGCGACCTCGGAGCGCCACTCGGATTTTGGATTTCGGTCTCGCATTCCGCGGCCGGGACTT
TCTCGAGGAGGACGCGCGCTGCTCCGCGCCCCCGAGTGCCCGGAGGACCCGGCATCCGGGGAGCCTCTCGCCCCTGTCCCGGAGGCGCGG
CGAGGATTGGCGGCGCCCGCCGCCCCCAGCCCCCCAGCGCGCGCCGGGGATGGAGCCGCAGCCCGGCGGCGCCCGGAGCTGCCGGCGCGG
GGCCCCCGGCGGCGCCTGCGAGCTGGGCCCGGCGGCCGAGGCGGCGCCCATGAGCCTCGCCATCCACAGCACCACGGGCACCCGCTACGA
CCTGGCCGTGCCGCCCGACGAGACGGTGGAGGGGCTGCGCAAGCGGTTGTCCCAGCGCCTCAAAGTGCCCAAGGAGCGCCTGGCTCTTCT
CCACAAAGACACCCGGCTCAGTTCGGGGAAGCTGCAGGAGTTCGGCGTGGGTGATGGCAGCAAGCTGACCTTGGTACCCACCGTGGAAGC
GGGCCTCATGTCTCAGGCCTCAAGGCCGGAACAGTCCGTGATGCAAGCTCTCGAGAGTCTCACGGAGACGCAGTGTTTTGGGCTGCTGGG
TGTGAATGGAGCAGGGAAGACGTCCACGTTTCGCATGGTGACGGGGGACACATTGGCCAGCAGGGGCGAGGCTGTGCTGGCAGGCCACAG
CGTGGCCCGGGAACCCAGTGCTGCGCACCTCAGCATGGGATACTGCCCTCAATCCGATGCCATCTTTGAGCTGCTGACGGGCCGCGAGCA
CCTGGAGCTGCTTGCGCGCCTGCGCGGTGTCCCGGAGGCCCAGGTTGCCCAGACCGCTGGCTCGGGCCTGGCGCGTCTGGGACTCTCATG
GTACGCAGACCGGCCTGCAGGCACCTACAGCGGAGGGAACAAACGCAAGCTGGCGACGGCCCTGGCGCTGGTTGGGGACCCAGCCGTGGT
GTTTCTGGACGAGCCGACCACAGGCATGGACCCCAGCGCGCGGCGCTTCCTTTGGAACAGCCTTTTGGCCGTGGTGCGGGAGGGCCGTTC
AGTGATGCTCACCTCCCATAGCATGGAGGAGTGTGAAGCGCTCTGCTCGCGCCTGGCCATCATGGTGAATGGGCGGTTCCGCTGCCTGGG
CAGCCCGCAACATCTCAAGGGCAGATTCGCGGCGGGTCACACACTGACCCTGCGGGTGCCCGCCGCAAGGTCCCAGCCGGCAGCGGCCTT
CGTGGCGGCCGAGTTCCCTGGGGCGGAGCTGCGCGAGGCACATGGAGGCCGCCTGCGCTTCCAGCTGCCGCCGGGAGGGCGCTGCGCCCT
GGCGCGCGTCTTTGGAGAGCTGGCGGTGCACGGCGCAGAGCACGGCGTGGAGGACTTTTCCGTGAGCCAGACGATGCTGGAGGAGGTATT
CTTGTACTTCTCCAAGGACCAGGGGAAGGACGAGGACACCGAAGAGCAGAAGGAGGCAGGAGTGGGAGTGGACCCCGCGCCAGGCCTGCA
GCACCCCAAACGCGTCAGCCAGTTCCTCGATGACCCTAGCACTGCCGAGACTGTGCTCTGAGCCTCCCTCCCCTGCGGGGCCGCGGGGAG
GCCCTGGGAATGGCAAGGGCAAGGTAGAGTGCCTAGGAGCCCTGGACTCAGGCTGGCAGAGGGGCTGGTGCCCTGGAGAAAATAAAGAGA

>53600_53600_4_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000591446_ABCA7_chr19_1061781_ENST00000263094_length(amino acids)=511AA_BP=24
MDFGLAFRGRDFLEEDARCSAPPSARRTRHPGSLSPLSRRRGEDWRRPPPPAPQRAPGMEPQPGGARSCRRGAPGGACELGPAAEAAPMS
LAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALE
SLTETQCFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQT
AGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRL
AIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED

--------------------------------------------------------------
>53600_53600_5_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000591446_ABCA7_chr19_1061781_ENST00000433129_length(transcript)=1915nt_BP=793nt
AGATCCTCCGAGCGGCGGCGACGGCTGTTGCTAAGGGAGGGGACGCGCGAGGAAGCGCGACCCGGGCGGCAGACGGCACCCAGCGCCACC
AGCCGAGCGGCGCCCCCTCCCCAGGACCCTTAACCGCGCCGCGTCCCGGTCGCGCCCGCCGCCCTTTGAAGGAGAAGCAAGTGCCGTCCC
CACCCCCGGAAGGCGCCCCCAGGAGCCGGAGCGACCTCGGAGCGCCACTCGGATTTTGGATTTCGGTCTCGCATTCCGCGGCCGGGACTT
TCTCGAGGAGGACGCGCGCTGCTCCGCGCCCCCGAGTGCCCGGAGGACCCGGCATCCGGGGAGCCTCTCGCCCCTGTCCCGGAGGCGCGG
CGAGGATTGGCGGCGCCCGCCGCCCCCAGCCCCCCAGCGCGCGCCGGGGATGGAGCCGCAGCCCGGCGGCGCCCGGAGCTGCCGGCGCGG
GGCCCCCGGCGGCGCCTGCGAGCTGGGCCCGGCGGCCGAGGCGGCGCCCATGAGCCTCGCCATCCACAGCACCACGGGCACCCGCTACGA
CCTGGCCGTGCCGCCCGACGAGACGGTGGAGGGGCTGCGCAAGCGGTTGTCCCAGCGCCTCAAAGTGCCCAAGGAGCGCCTGGCTCTTCT
CCACAAAGACACCCGGCTCAGTTCGGGGAAGCTGCAGGAGTTCGGCGTGGGTGATGGCAGCAAGCTGACCTTGGTACCCACCGTGGAAGC
GGGCCTCATGTCTCAGGCCTCAAGGCCGGAACAGTCCGTGATGCAAGCTCTCGAGAGTCTCACGGAGACGCAGTGTTTTGGGCTGCTGGG
TGTGAATGGAGCAGGGAAGACGTCCACGTTTCGCATGGTGACGGGGGACACATTGGCCAGCAGGGGCGAGGCTGTGCTGGCAGGCCACAG
CGTGGCCCGGGAACCCAGTGCTGCGCACCTCAGCATGGGATACTGCCCTCAATCCGATGCCATCTTTGAGCTGCTGACGGGCCGCGAGCA
CCTGGAGCTGCTTGCGCGCCTGCGCGGTGTCCCGGAGGCCCAGGTTGCCCAGACCGCTGGCTCGGGCCTGGCGCGTCTGGGACTCTCATG
GTACGCAGACCGGCCTGCAGGCACCTACAGCGGAGGGAACAAACGCAAGCTGGCGACGGCCCTGGCGCTGGTTGGGGACCCAGCCGTGGT
GTTTCTGGACGAGCCGACCACAGGCATGGACCCCAGCGCGCGGCGCTTCCTTTGGAACAGCCTTTTGGCCGTGGTGCGGGAGGGCCGTTC
AGTGATGCTCACCTCCCATAGCATGGAGGAGTGTGAAGCGCTCTGCTCGCGCCTGGCCATCATGGTGAATGGGCGGTTCCGCTGCCTGGG
CAGCCCGCAACATCTCAAGGGCAGATTCGCGGCGGGTCACACACTGACCCTGCGGGTGCCCGCCGCAAGGTCCCAGCCGGCAGCGGCCTT
CGTGGCGGCCGAGTTCCCTGGGGCGGAGCTGCGCGAGGCACATGGAGGCCGCCTGCGCTTCCAGCTGCCGCCGGGAGGGCGCTGCGCCCT
GGCGCGCGTCTTTGGAGAGCTGGCGGTGCACGGCGCAGAGCACGGCGTGGAGGACTTTTCCGTGAGCCAGACGATGCTGGAGGAGGTATT
CTTGTACTTCTCCAAGGACCAGGGGAAGGACGAGGACACCGAAGAGCAGAAGGAGGCAGGAGTGGGAGTGGACCCCGCGCCAGGCCTGCA
GCACCCCAAACGCGTCAGCCAGTTCCTCGATGACCCTAGCACTGCCGAGACTGTGCTCTGAGCCTCCCTCCCCTGCGGGGCCGCGGGGAG
GCCCTGGGAATGGCAAGGGCAAGGTAGAGTGCCTAGGAGCCCTGGACTCAGGCTGGCAGAGGGGCTGGTGCCCTGGAGAAAATAAAGAGA

>53600_53600_5_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000591446_ABCA7_chr19_1061781_ENST00000433129_length(amino acids)=511AA_BP=24
MDFGLAFRGRDFLEEDARCSAPPSARRTRHPGSLSPLSRRRGEDWRRPPPPAPQRAPGMEPQPGGARSCRRGAPGGACELGPAAEAAPMS
LAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALE
SLTETQCFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQT
AGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRL
AIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED

--------------------------------------------------------------
>53600_53600_6_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000591446_ABCA7_chr19_1061781_ENST00000435683_length(transcript)=1771nt_BP=793nt
AGATCCTCCGAGCGGCGGCGACGGCTGTTGCTAAGGGAGGGGACGCGCGAGGAAGCGCGACCCGGGCGGCAGACGGCACCCAGCGCCACC
AGCCGAGCGGCGCCCCCTCCCCAGGACCCTTAACCGCGCCGCGTCCCGGTCGCGCCCGCCGCCCTTTGAAGGAGAAGCAAGTGCCGTCCC
CACCCCCGGAAGGCGCCCCCAGGAGCCGGAGCGACCTCGGAGCGCCACTCGGATTTTGGATTTCGGTCTCGCATTCCGCGGCCGGGACTT
TCTCGAGGAGGACGCGCGCTGCTCCGCGCCCCCGAGTGCCCGGAGGACCCGGCATCCGGGGAGCCTCTCGCCCCTGTCCCGGAGGCGCGG
CGAGGATTGGCGGCGCCCGCCGCCCCCAGCCCCCCAGCGCGCGCCGGGGATGGAGCCGCAGCCCGGCGGCGCCCGGAGCTGCCGGCGCGG
GGCCCCCGGCGGCGCCTGCGAGCTGGGCCCGGCGGCCGAGGCGGCGCCCATGAGCCTCGCCATCCACAGCACCACGGGCACCCGCTACGA
CCTGGCCGTGCCGCCCGACGAGACGGTGGAGGGGCTGCGCAAGCGGTTGTCCCAGCGCCTCAAAGTGCCCAAGGAGCGCCTGGCTCTTCT
CCACAAAGACACCCGGCTCAGTTCGGGGAAGCTGCAGGAGTTCGGCGTGGGTGATGGCAGCAAGCTGACCTTGGTACCCACCGTGGAAGC
GGGCCTCATGTCTCAGGCCTCAAGGCCGGAACAGTCCGTGATGCAAGCTCTCGAGAGTCTCACGGAGACGCAGTGTTTTGGGCTGCTGGG
TGTGAATGGAGCAGGGAAGACGTCCACGTTTCGCATGGTGACGGGGGACACATTGGCCAGCAGGGGCGAGGCTGTGCTGGCAGGCCACAG
CGTGGCCCGGGAACCCAGTGCTGCGCACCTCAGCATGGGATACTGCCCTCAATCCGATGCCATCTTTGAGCTGCTGACGGGCCGCGAGCA
CCTGGAGCTGCTTGCGCGCCTGCGCGGTGTCCCGGAGGCCCAGGTTGCCCAGACCGCTGGCTCGGGCCTGGCGCGTCTGGGACTCTCATG
GTACGCAGACCGGCCTGCAGGCACCTACAGCGGAGGGAACAAACGCAAGCTGGCGACGGCCCTGGCGCTGGTTGGGGACCCAGCCGTGGT
GTTTCTGGACGAGCCGACCACAGGCATGGACCCCAGCGCGCGGCGCTTCCTTTGGAACAGCCTTTTGGCCGTGGTGCGGGAGGGCCGTTC
AGTGATGCTCACCTCCCATAGCATGGAGGAGTGTGAAGCGCTCTGCTCGCGCCTGGCCATCATGGTGAATGGGCGGTTCCGCTGCCTGGG
CAGCCCGCAACATCTCAAGGGCAGATTCGCGGCGGGTCACACACTGACCCTGCGGGTGCCCGCCGCAAGGTCCCAGCCGGCAGCGGCCTT
CGTGGCGGCCGAGTTCCCTGGGGCGGAGCTGCGCGAGGCACATGGAGGCCGCCTGCGCTTCCAGCTGCCGCCGGGAGGGCGCTGCGCCCT
GGCGCGCGTCTTTGGAGAGCTGGCGGTGCACGGCGCAGAGCACGGCGTGGAGGACTTTTCCGTGAGCCAGACGATGCTGGAGGAGGTATT
CTTGTACTTCTCCAAGGACCAGGGGAAGGACGAGGACACCGAAGAGCAGAAGGAGGCAGGAGTGGGAGTGGACCCCGCGCCAGGCCTGCA

>53600_53600_6_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000591446_ABCA7_chr19_1061781_ENST00000435683_length(amino acids)=512AA_BP=24
MDFGLAFRGRDFLEEDARCSAPPSARRTRHPGSLSPLSRRRGEDWRRPPPPAPQRAPGMEPQPGGARSCRRGAPGGACELGPAAEAAPMS
LAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALE
SLTETQCFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQT
AGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRL
AIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MIDN-ABCA7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MIDN-ABCA7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MIDN-ABCA7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource