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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MIER1-SLC26A5 (FusionGDB2 ID:53633)

Fusion Gene Summary for MIER1-SLC26A5

Fusion gene summary

Fusion gene information	Fusion gene name: MIER1-SLC26A5
	Fusion gene ID: 53633
		Hgene	Tgene
	Gene symbol	MIER1	SLC26A5
	Gene ID	57708	375611
	Gene name	MIER1 transcriptional regulator	solute carrier family 26 member 5
	Synonyms	ER1\|MI-ER1	DFNB61\|PRES
	Cytomap	1p31.3	7q22.1
	Type of gene	protein-coding	protein-coding
	Description	mesoderm induction early response protein 1mesoderm induction early response 1 homologmesoderm induction early response 1, transcriptional regulator	prestinprestin (motor protein)solute carrier family 26 (anion exchanger), member 5
	Modification date	20200313	20200313
	UniProtAcc	Q8N108	.
	Ensembl transtripts involved in fusion gene	ENST00000355356, ENST00000355977, ENST00000357692, ENST00000371018, ENST00000371012, ENST00000371014, ENST00000371016, ENST00000401041, ENST00000401042, ENST00000479067,	ENST00000306312, ENST00000339444, ENST00000354356, ENST00000356767, ENST00000393723, ENST00000393727, ENST00000393729, ENST00000393730, ENST00000393735, ENST00000432958,
Fusion gene scores	* DoF score	6 X 5 X 3=90	8 X 8 X 6=384
	# samples	6	12
	** MAII score	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/384*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MIER1 [Title/Abstract] AND SLC26A5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MIER1(67453347)-SLC26A5(103015165), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MIER1	GO:0016575	histone deacetylation	28046085
Hgene	MIER1	GO:0031937	positive regulation of chromatin silencing	12482978

Fusion gene breakpoints across MIER1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SLC26A5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BF218057	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-

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Fusion Gene ORF analysis for MIER1-SLC26A5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-intron	ENST00000355356	ENST00000306312	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355356	ENST00000339444	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355356	ENST00000354356	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355356	ENST00000356767	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355356	ENST00000393723	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355356	ENST00000393727	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355356	ENST00000393729	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355356	ENST00000393730	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355356	ENST00000393735	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355356	ENST00000432958	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355977	ENST00000306312	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355977	ENST00000339444	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355977	ENST00000354356	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355977	ENST00000356767	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355977	ENST00000393723	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355977	ENST00000393727	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355977	ENST00000393729	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355977	ENST00000393730	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355977	ENST00000393735	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000355977	ENST00000432958	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000357692	ENST00000306312	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000357692	ENST00000339444	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000357692	ENST00000354356	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000357692	ENST00000356767	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000357692	ENST00000393723	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000357692	ENST00000393727	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000357692	ENST00000393729	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000357692	ENST00000393730	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000357692	ENST00000393735	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000357692	ENST00000432958	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000371018	ENST00000306312	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000371018	ENST00000339444	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000371018	ENST00000354356	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000371018	ENST00000356767	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000371018	ENST00000393723	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000371018	ENST00000393727	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000371018	ENST00000393729	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000371018	ENST00000393730	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000371018	ENST00000393735	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
3UTR-intron	ENST00000371018	ENST00000432958	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371012	ENST00000306312	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371012	ENST00000339444	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371012	ENST00000354356	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371012	ENST00000356767	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371012	ENST00000393723	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371012	ENST00000393727	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371012	ENST00000393729	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371012	ENST00000393730	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371012	ENST00000393735	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371012	ENST00000432958	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371014	ENST00000306312	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371014	ENST00000339444	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371014	ENST00000354356	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371014	ENST00000356767	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371014	ENST00000393723	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371014	ENST00000393727	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371014	ENST00000393729	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371014	ENST00000393730	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371014	ENST00000393735	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371014	ENST00000432958	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371016	ENST00000306312	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371016	ENST00000339444	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371016	ENST00000354356	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371016	ENST00000356767	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371016	ENST00000393723	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371016	ENST00000393727	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371016	ENST00000393729	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371016	ENST00000393730	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371016	ENST00000393735	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000371016	ENST00000432958	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401041	ENST00000306312	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401041	ENST00000339444	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401041	ENST00000354356	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401041	ENST00000356767	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401041	ENST00000393723	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401041	ENST00000393727	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401041	ENST00000393729	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401041	ENST00000393730	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401041	ENST00000393735	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401041	ENST00000432958	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401042	ENST00000306312	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401042	ENST00000339444	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401042	ENST00000354356	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401042	ENST00000356767	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401042	ENST00000393723	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401042	ENST00000393727	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401042	ENST00000393729	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401042	ENST00000393730	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401042	ENST00000393735	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000401042	ENST00000432958	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000479067	ENST00000306312	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000479067	ENST00000339444	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000479067	ENST00000354356	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000479067	ENST00000356767	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000479067	ENST00000393723	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000479067	ENST00000393727	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000479067	ENST00000393729	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000479067	ENST00000393730	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000479067	ENST00000393735	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-
intron-intron	ENST00000479067	ENST00000432958	MIER1	chr1	67453347	+	SLC26A5	chr7	103015165	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for MIER1-SLC26A5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MIER1-SLC26A5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:67453347/:103015165)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MIER1 Q8N108	.
FUNCTION: Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269\|PubMed:12482978}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for MIER1-SLC26A5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MIER1-SLC26A5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MIER1-SLC26A5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MIER1-SLC26A5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source