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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MIER1-WLS (FusionGDB2 ID:53634)

Fusion Gene Summary for MIER1-WLS

check button Fusion gene summary
Fusion gene informationFusion gene name: MIER1-WLS
Fusion gene ID: 53634
HgeneTgene
Gene symbol

MIER1

WLS

Gene ID

57708

79971

Gene nameMIER1 transcriptional regulatorWnt ligand secretion mediator
SynonymsER1|MI-ER1C1orf139|EVI|GPR177|MRP|mig-14
Cytomap

1p31.3

1p31.3

Type of geneprotein-codingprotein-coding
Descriptionmesoderm induction early response protein 1mesoderm induction early response 1 homologmesoderm induction early response 1, transcriptional regulatorprotein wntless homologG protein-coupled receptor 177integral membrane protein GPR177protein evenness interrupted homologputative NF-kappa-B-activating protein 373putative NFkB activating protein 373wntless Wnt ligand secretion mediator
Modification date2020031320200313
UniProtAcc

Q8N108

.
Ensembl transtripts involved in fusion geneENST00000355356, ENST00000355977, 
ENST00000357692, ENST00000371014, 
ENST00000371016, ENST00000371018, 
ENST00000401041, ENST00000401042, 
ENST00000371012, ENST00000479067, 
ENST00000262348, ENST00000354777, 
ENST00000370971, ENST00000370976, 
ENST00000491811, ENST00000540432, 
Fusion gene scores* DoF score6 X 5 X 3=9013 X 8 X 7=728
# samples 613
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/728*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MIER1 [Title/Abstract] AND WLS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMIER1(67428843)-WLS(68659912), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMIER1

GO:0016575

histone deacetylation

28046085

HgeneMIER1

GO:0031937

positive regulation of chromatin silencing

12482978


check buttonFusion gene breakpoints across MIER1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WLS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAK074990MIER1chr1

67428843

+WLSchr1

68659912

-
ChiTaRS5.0N/ADA736803MIER1chr1

67428843

+WLSchr1

68659912

-


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Fusion Gene ORF analysis for MIER1-WLS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000355356ENST00000262348MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000355356ENST00000354777MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000355356ENST00000370971MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000355356ENST00000370976MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000355356ENST00000491811MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000355977ENST00000262348MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000355977ENST00000354777MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000355977ENST00000370971MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000355977ENST00000370976MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000355977ENST00000491811MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000357692ENST00000262348MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000357692ENST00000354777MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000357692ENST00000370971MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000357692ENST00000370976MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000357692ENST00000491811MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000371014ENST00000262348MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000371014ENST00000354777MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000371014ENST00000370971MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000371014ENST00000370976MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000371014ENST00000491811MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000371016ENST00000262348MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000371016ENST00000354777MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000371016ENST00000370971MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000371016ENST00000370976MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000371016ENST00000491811MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000371018ENST00000262348MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000371018ENST00000354777MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000371018ENST00000370971MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000371018ENST00000370976MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000371018ENST00000491811MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000401041ENST00000262348MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000401041ENST00000354777MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000401041ENST00000370971MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000401041ENST00000370976MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000401041ENST00000491811MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000401042ENST00000262348MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000401042ENST00000354777MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000401042ENST00000370971MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000401042ENST00000370976MIER1chr1

67428843

+WLSchr1

68659912

-
5CDS-intronENST00000401042ENST00000491811MIER1chr1

67428843

+WLSchr1

68659912

-
In-frameENST00000355356ENST00000540432MIER1chr1

67428843

+WLSchr1

68659912

-
In-frameENST00000355977ENST00000540432MIER1chr1

67428843

+WLSchr1

68659912

-
In-frameENST00000357692ENST00000540432MIER1chr1

67428843

+WLSchr1

68659912

-
In-frameENST00000371014ENST00000540432MIER1chr1

67428843

+WLSchr1

68659912

-
In-frameENST00000371016ENST00000540432MIER1chr1

67428843

+WLSchr1

68659912

-
In-frameENST00000371018ENST00000540432MIER1chr1

67428843

+WLSchr1

68659912

-
In-frameENST00000401041ENST00000540432MIER1chr1

67428843

+WLSchr1

68659912

-
In-frameENST00000401042ENST00000540432MIER1chr1

67428843

+WLSchr1

68659912

-
intron-3CDSENST00000371012ENST00000540432MIER1chr1

67428843

+WLSchr1

68659912

-
intron-3CDSENST00000479067ENST00000540432MIER1chr1

67428843

+WLSchr1

68659912

-
intron-intronENST00000371012ENST00000262348MIER1chr1

67428843

+WLSchr1

68659912

-
intron-intronENST00000371012ENST00000354777MIER1chr1

67428843

+WLSchr1

68659912

-
intron-intronENST00000371012ENST00000370971MIER1chr1

67428843

+WLSchr1

68659912

-
intron-intronENST00000371012ENST00000370976MIER1chr1

67428843

+WLSchr1

68659912

-
intron-intronENST00000371012ENST00000491811MIER1chr1

67428843

+WLSchr1

68659912

-
intron-intronENST00000479067ENST00000262348MIER1chr1

67428843

+WLSchr1

68659912

-
intron-intronENST00000479067ENST00000354777MIER1chr1

67428843

+WLSchr1

68659912

-
intron-intronENST00000479067ENST00000370971MIER1chr1

67428843

+WLSchr1

68659912

-
intron-intronENST00000479067ENST00000370976MIER1chr1

67428843

+WLSchr1

68659912

-
intron-intronENST00000479067ENST00000491811MIER1chr1

67428843

+WLSchr1

68659912

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371018MIER1chr167428843+ENST00000540432WLSchr168659912-26859802622511749
ENST00000355977MIER1chr167428843+ENST00000540432WLSchr168659912-24657603062291661
ENST00000357692MIER1chr167428843+ENST00000540432WLSchr168659912-26269212002452750
ENST00000401041MIER1chr167428843+ENST00000540432WLSchr168659912-2547842702373767
ENST00000371016MIER1chr167428843+ENST00000540432WLSchr168659912-26219161982447749
ENST00000371014MIER1chr167428843+ENST00000540432WLSchr168659912-2547842702373767
ENST00000401042MIER1chr167428843+ENST00000540432WLSchr168659912-24677621492293714
ENST00000355356MIER1chr167428843+ENST00000540432WLSchr168659912-24677621492293714

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371018ENST00000540432MIER1chr167428843+WLSchr168659912-0.0007982150.99920183
ENST00000355977ENST00000540432MIER1chr167428843+WLSchr168659912-0.000930810.9990693
ENST00000357692ENST00000540432MIER1chr167428843+WLSchr168659912-0.000734910.99926513
ENST00000401041ENST00000540432MIER1chr167428843+WLSchr168659912-0.0016759310.9983241
ENST00000371016ENST00000540432MIER1chr167428843+WLSchr168659912-0.0007310680.99926895
ENST00000371014ENST00000540432MIER1chr167428843+WLSchr168659912-0.0016759310.9983241
ENST00000401042ENST00000540432MIER1chr167428843+WLSchr168659912-0.0006404240.99935955
ENST00000355356ENST00000540432MIER1chr167428843+WLSchr168659912-0.0006404240.99935955

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Fusion Genomic Features for MIER1-WLS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MIER1-WLS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:67428843/chr1:68659912)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIER1

Q8N108

.
FUNCTION: Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269|PubMed:12482978}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMIER1chr1:67428843chr1:68659912ENST00000355356+71336_181204513.0Compositional biasNote=Glu-rich
HgeneMIER1chr1:67428843chr1:68659912ENST00000357692+91536_181221530.0Compositional biasNote=Glu-rich
HgeneMIER1chr1:67428843chr1:68659912ENST00000371014+81536_181257487.0Compositional biasNote=Glu-rich
HgeneMIER1chr1:67428843chr1:68659912ENST00000371016+91636_181221451.0Compositional biasNote=Glu-rich
HgeneMIER1chr1:67428843chr1:68659912ENST00000371018+91636_181221471.0Compositional biasNote=Glu-rich
HgeneMIER1chr1:67428843chr1:68659912ENST00000401041+81436_181257566.0Compositional biasNote=Glu-rich
HgeneMIER1chr1:67428843chr1:68659912ENST00000401042+71436_181204434.0Compositional biasNote=Glu-rich
TgeneWLSchr1:67428843chr1:68659912ENST00000262348012254_26835542.0Topological domainCytoplasmic
TgeneWLSchr1:67428843chr1:68659912ENST00000262348012290_30335542.0Topological domainLumenal
TgeneWLSchr1:67428843chr1:68659912ENST00000262348012325_33135542.0Topological domainCytoplasmic
TgeneWLSchr1:67428843chr1:68659912ENST00000262348012353_38035542.0Topological domainLumenal
TgeneWLSchr1:67428843chr1:68659912ENST0000026234801237_23235542.0Topological domainLumenal
TgeneWLSchr1:67428843chr1:68659912ENST00000262348012402_43135542.0Topological domainCytoplasmic
TgeneWLSchr1:67428843chr1:68659912ENST00000262348012453_47135542.0Topological domainLumenal
TgeneWLSchr1:67428843chr1:68659912ENST00000262348012493_54135542.0Topological domainCytoplasmic
TgeneWLSchr1:67428843chr1:68659912ENST000003547770121_150544.0Topological domainCytoplasmic
TgeneWLSchr1:67428843chr1:68659912ENST00000354777012254_2680544.0Topological domainCytoplasmic
TgeneWLSchr1:67428843chr1:68659912ENST00000354777012290_3030544.0Topological domainLumenal
TgeneWLSchr1:67428843chr1:68659912ENST00000354777012325_3310544.0Topological domainCytoplasmic
TgeneWLSchr1:67428843chr1:68659912ENST00000354777012353_3800544.0Topological domainLumenal
TgeneWLSchr1:67428843chr1:68659912ENST0000035477701237_2320544.0Topological domainLumenal
TgeneWLSchr1:67428843chr1:68659912ENST00000354777012402_4310544.0Topological domainCytoplasmic
TgeneWLSchr1:67428843chr1:68659912ENST00000354777012453_4710544.0Topological domainLumenal
TgeneWLSchr1:67428843chr1:68659912ENST00000354777012493_5410544.0Topological domainCytoplasmic
TgeneWLSchr1:67428843chr1:68659912ENST000003709760111_150451.0Topological domainCytoplasmic
TgeneWLSchr1:67428843chr1:68659912ENST00000370976011254_2680451.0Topological domainCytoplasmic
TgeneWLSchr1:67428843chr1:68659912ENST00000370976011290_3030451.0Topological domainLumenal
TgeneWLSchr1:67428843chr1:68659912ENST00000370976011325_3310451.0Topological domainCytoplasmic
TgeneWLSchr1:67428843chr1:68659912ENST00000370976011353_3800451.0Topological domainLumenal
TgeneWLSchr1:67428843chr1:68659912ENST0000037097601137_2320451.0Topological domainLumenal
TgeneWLSchr1:67428843chr1:68659912ENST00000370976011402_4310451.0Topological domainCytoplasmic
TgeneWLSchr1:67428843chr1:68659912ENST00000370976011453_4710451.0Topological domainLumenal
TgeneWLSchr1:67428843chr1:68659912ENST00000370976011493_5410451.0Topological domainCytoplasmic
TgeneWLSchr1:67428843chr1:68659912ENST00000262348012233_25335542.0TransmembraneHelical%3B Name%3D2
TgeneWLSchr1:67428843chr1:68659912ENST00000262348012269_28935542.0TransmembraneHelical%3B Name%3D3
TgeneWLSchr1:67428843chr1:68659912ENST00000262348012304_32435542.0TransmembraneHelical%3B Name%3D4
TgeneWLSchr1:67428843chr1:68659912ENST00000262348012332_35235542.0TransmembraneHelical%3B Name%3D5
TgeneWLSchr1:67428843chr1:68659912ENST00000262348012381_40135542.0TransmembraneHelical%3B Name%3D6
TgeneWLSchr1:67428843chr1:68659912ENST00000262348012432_45235542.0TransmembraneHelical%3B Name%3D7
TgeneWLSchr1:67428843chr1:68659912ENST00000262348012472_49235542.0TransmembraneHelical%3B Name%3D8
TgeneWLSchr1:67428843chr1:68659912ENST0000035477701216_360544.0TransmembraneHelical%3B Name%3D1
TgeneWLSchr1:67428843chr1:68659912ENST00000354777012233_2530544.0TransmembraneHelical%3B Name%3D2
TgeneWLSchr1:67428843chr1:68659912ENST00000354777012269_2890544.0TransmembraneHelical%3B Name%3D3
TgeneWLSchr1:67428843chr1:68659912ENST00000354777012304_3240544.0TransmembraneHelical%3B Name%3D4
TgeneWLSchr1:67428843chr1:68659912ENST00000354777012332_3520544.0TransmembraneHelical%3B Name%3D5
TgeneWLSchr1:67428843chr1:68659912ENST00000354777012381_4010544.0TransmembraneHelical%3B Name%3D6
TgeneWLSchr1:67428843chr1:68659912ENST00000354777012432_4520544.0TransmembraneHelical%3B Name%3D7
TgeneWLSchr1:67428843chr1:68659912ENST00000354777012472_4920544.0TransmembraneHelical%3B Name%3D8
TgeneWLSchr1:67428843chr1:68659912ENST0000037097601116_360451.0TransmembraneHelical%3B Name%3D1
TgeneWLSchr1:67428843chr1:68659912ENST00000370976011233_2530451.0TransmembraneHelical%3B Name%3D2
TgeneWLSchr1:67428843chr1:68659912ENST00000370976011269_2890451.0TransmembraneHelical%3B Name%3D3
TgeneWLSchr1:67428843chr1:68659912ENST00000370976011304_3240451.0TransmembraneHelical%3B Name%3D4
TgeneWLSchr1:67428843chr1:68659912ENST00000370976011332_3520451.0TransmembraneHelical%3B Name%3D5
TgeneWLSchr1:67428843chr1:68659912ENST00000370976011381_4010451.0TransmembraneHelical%3B Name%3D6
TgeneWLSchr1:67428843chr1:68659912ENST00000370976011432_4520451.0TransmembraneHelical%3B Name%3D7
TgeneWLSchr1:67428843chr1:68659912ENST00000370976011472_4920451.0TransmembraneHelical%3B Name%3D8

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMIER1chr1:67428843chr1:68659912ENST00000355977+71436_181141371.0Compositional biasNote=Glu-rich
HgeneMIER1chr1:67428843chr1:68659912ENST00000355356+713180_278204513.0DomainELM2
HgeneMIER1chr1:67428843chr1:68659912ENST00000355356+713283_335204513.0DomainSANT
HgeneMIER1chr1:67428843chr1:68659912ENST00000355977+714180_278141371.0DomainELM2
HgeneMIER1chr1:67428843chr1:68659912ENST00000355977+714283_335141371.0DomainSANT
HgeneMIER1chr1:67428843chr1:68659912ENST00000357692+915180_278221530.0DomainELM2
HgeneMIER1chr1:67428843chr1:68659912ENST00000357692+915283_335221530.0DomainSANT
HgeneMIER1chr1:67428843chr1:68659912ENST00000371014+815180_278257487.0DomainELM2
HgeneMIER1chr1:67428843chr1:68659912ENST00000371014+815283_335257487.0DomainSANT
HgeneMIER1chr1:67428843chr1:68659912ENST00000371016+916180_278221451.0DomainELM2
HgeneMIER1chr1:67428843chr1:68659912ENST00000371016+916283_335221451.0DomainSANT
HgeneMIER1chr1:67428843chr1:68659912ENST00000371018+916180_278221471.0DomainELM2
HgeneMIER1chr1:67428843chr1:68659912ENST00000371018+916283_335221471.0DomainSANT
HgeneMIER1chr1:67428843chr1:68659912ENST00000401041+814180_278257566.0DomainELM2
HgeneMIER1chr1:67428843chr1:68659912ENST00000401041+814283_335257566.0DomainSANT
HgeneMIER1chr1:67428843chr1:68659912ENST00000401042+714180_278204434.0DomainELM2
HgeneMIER1chr1:67428843chr1:68659912ENST00000401042+714283_335204434.0DomainSANT
TgeneWLSchr1:67428843chr1:68659912ENST000002623480121_1535542.0Topological domainCytoplasmic
TgeneWLSchr1:67428843chr1:68659912ENST0000026234801216_3635542.0TransmembraneHelical%3B Name%3D1


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Fusion Gene Sequence for MIER1-WLS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>53634_53634_1_MIER1-WLS_MIER1_chr1_67428843_ENST00000355356_WLS_chr1_68659912_ENST00000540432_length(transcript)=2467nt_BP=762nt
GCGGCTCCTGCGCGTTCCCGCCGAGGCAGTGGCGGCGGGAGCGGCAGAGACGGCAGCGGCCGGAGTCCCGTTGCTGAGTCTCACATCCGG
GTTCTGGCCGTGACCCAGCTGCGGCCGCCGCGGAGATGTGACCCGGCAGTACGGCAAATATGGCGGAGCCATCTGTTGAATCTTCAAGTC
CAGGAGGTTCAGCAACATCAGATGACCATGAATTTGATCCATCAGCTGACATGCTGGTTCATGATTTTGATGATGAACGAACATTAGAAG
AGGAAGAAATGATGGAAGGAGAAACAAACTTCAGCTCTGAAATAGAAGATCTTGCAAGGGAAGGCGACATGCCAATTCATGAACTTCTCA
GCCTTTATGGTTATGGTAGTACTGTTCGACTACCTGAAGAAGATGAGGAAGAGGAAGAAGAGGAAGAAGAAGGTGAAGATGATGAAGATG
CTGATAATGATGACAACAGTGGCTGTAGTGGGGAAAATAAAGAGGAGAATATAAAGGATTCATCAGGTCAGGAGGATGAAACTCAGTCTT
CCAATGATGATCCATCACAATCTGTTGCTTCTCAAGATGCCCAGGAAATAATCCGCCCACGTCGATGTAAATATTTTGATACAAATAGTG
AAGTAGAAGAAGAATCTGAAGAAGATGAAGATTATATTCCATCAGAAGACTGGAAAAAGGAGATTATGGTGGGCTCCATGTTTCAAGCAG
AAATTCCAGTTGGCATTTGTAGATACAAAGAAAATGAAAAAGCTCCAGGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGG
ATGCCCGTAAGAACCATCACAAGACAAAATGGTTCGTGCCTTGGGGACCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTC
CAAGGGAAATTGAAGCCAATGACATCGTGTTTTCTGTTCACATTCCCCTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGT
TTATCCTGCAGCTGGACATTGCCTTCAAGCTAAACAACCAAATCAGAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTG
ATGACGCGTTTGCTGAGTGGACTGAAATGGCCCATGAAAGAGTACCACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGC
ATGAGGGCCGTTACTATGAATGTGATGTCCTTCCTTTCATGGAAATTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGC
CTGTGAATGAGAAGAAGAAAATCAATGTGGGAATTGGGGAGATAAAGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCA
AGGTGTGGTTTGCCATGAAGACCTTCCTTACGCCCAGCATCTTCATCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGAC
CCCCAGTGCTTCTGGAAAAAGTCATCTTTGCCCTTGGGATTTCCATGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTG
ACTGGACCTGGATGCTGCTGTTTGGTGACATCCGACAGGGCATCTTCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGC
ACATGATGGATCAGCACGAGCGGAACCACATCGCAGGGTATTGGAAGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATAT
TTGACATGTGTGAGAGAGGGGTACAACTCACGAATCCCTTCTACAGTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCA
TCATCGTGGCTGGAATCTGCCTCTGCCTCTACTTCCTGTTTCTATGCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGT
CCAGCCTGCCAGCTATGAGCAAAGTCCGGCGGCTACACTATGAGGGGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCT
GCGCTGCCATGACTGTCATCTTCTTCATCGTTAGTCAGGTAACGGAAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTG
CCTTTTTCACAGGCATCTATGGGATGTGGAATCTGTATGTCTTTGCTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAG
ACCAGTCCAATGGAATGCAACTCCCATGTAAATCGAGGGAAGATTGTGCTTTGTTTGTTTCGGAACTTTATCAAGAATTGTTCAGCGCTT
CGAAATATTCCTTCATCAATGACAACGCAGCTTCTGGTATTTGAGTCAACAAGGCAACACATGTTTATCAGCTTTGCATTTGCAGTTGTC
ACAGTCACATTGATTGTACTTGTATACGCACACAAATACACTCATTTAGCCTTTATCTCAAAATGTTAAATATAAGGAAAAAAGCGTCAA

>53634_53634_1_MIER1-WLS_MIER1_chr1_67428843_ENST00000355356_WLS_chr1_68659912_ENST00000540432_length(amino acids)=714AA_BP=204
MAEPSVESSSPGGSATSDDHEFDPSADMLVHDFDDERTLEEEEMMEGETNFSSEIEDLAREGDMPIHELLSLYGYGSTVRLPEEDEEEEE
EEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVASQDAQEIIRPRRCKYFDTNSEVEEESEEDEDYIPSEDWKK
EIMVGSMFQAEIPVGICRYKENEKAPGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHM
EMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVA
HKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFIN
IPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTT
DIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWK

--------------------------------------------------------------
>53634_53634_2_MIER1-WLS_MIER1_chr1_67428843_ENST00000355977_WLS_chr1_68659912_ENST00000540432_length(transcript)=2465nt_BP=760nt
AGGAGGGCGGAGGCGGAGGGGAGGGCAGAGGGTTGGTGGAGCTGGAGGAAGCTCCGGACGACGACTGGAAGAAGGAGGCGGGCGGCCCGG
GCCTCAGGCCCCTCCCAGGCTCTGAGTCTCCCGGCTGCAGGCGGATGGATGGGGCTTCTTCAGGCGGTGGCGGCAGCAGCGAAGGTGGCG
GCGGCAGCAGCGGCAGCGGCTATGGTGTGGTCGCTCGATTCTCCCAGTGCCTGGCTGAGTTTCGGACGTGGTTAAGAACCAACTGGTTGA
GGTTCAATGCAGACAAGACGGATGTGATGCTGCCATCTGTTGAATCTTCAAGTCCAGGAAGGCGACATGCCAATTCATGAACTTCTCAGC
CTTTATGGTTATGGTAGTACTGTTCGACTACCTGAAGAAGATGAGGAAGAGGAAGAAGAGGAAGAAGAAGGTGAAGATGATGAAGATGCT
GATAATGATGACAACAGTGGCTGTAGTGGGGAAAATAAAGAGGAGAATATAAAGGATTCATCAGGTCAGGAGGATGAAACTCAGTCTTCC
AATGATGATCCATCACAATCTGTTGCTTCTCAAGATGCCCAGGAAATAATCCGCCCACGTCGATGTAAATATTTTGATACAAATAGTGAA
GTAGAAGAAGAATCTGAAGAAGATGAAGATTATATTCCATCAGAAGACTGGAAAAAGGAGATTATGGTGGGCTCCATGTTTCAAGCAGAA
ATTCCAGTTGGCATTTGTAGATACAAAGAAAATGAAAAAGCTCCAGGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGAT
GCCCGTAAGAACCATCACAAGACAAAATGGTTCGTGCCTTGGGGACCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCA
AGGGAAATTGAAGCCAATGACATCGTGTTTTCTGTTCACATTCCCCTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTT
ATCCTGCAGCTGGACATTGCCTTCAAGCTAAACAACCAAATCAGAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGAT
GACGCGTTTGCTGAGTGGACTGAAATGGCCCATGAAAGAGTACCACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCAT
GAGGGCCGTTACTATGAATGTGATGTCCTTCCTTTCATGGAAATTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCT
GTGAATGAGAAGAAGAAAATCAATGTGGGAATTGGGGAGATAAAGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAG
GTGTGGTTTGCCATGAAGACCTTCCTTACGCCCAGCATCTTCATCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCC
CCAGTGCTTCTGGAAAAAGTCATCTTTGCCCTTGGGATTTCCATGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGAC
TGGACCTGGATGCTGCTGTTTGGTGACATCCGACAGGGCATCTTCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCAC
ATGATGGATCAGCACGAGCGGAACCACATCGCAGGGTATTGGAAGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTT
GACATGTGTGAGAGAGGGGTACAACTCACGAATCCCTTCTACAGTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATC
ATCGTGGCTGGAATCTGCCTCTGCCTCTACTTCCTGTTTCTATGCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCC
AGCCTGCCAGCTATGAGCAAAGTCCGGCGGCTACACTATGAGGGGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGC
GCTGCCATGACTGTCATCTTCTTCATCGTTAGTCAGGTAACGGAAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCC
TTTTTCACAGGCATCTATGGGATGTGGAATCTGTATGTCTTTGCTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGAC
CAGTCCAATGGAATGCAACTCCCATGTAAATCGAGGGAAGATTGTGCTTTGTTTGTTTCGGAACTTTATCAAGAATTGTTCAGCGCTTCG
AAATATTCCTTCATCAATGACAACGCAGCTTCTGGTATTTGAGTCAACAAGGCAACACATGTTTATCAGCTTTGCATTTGCAGTTGTCAC
AGTCACATTGATTGTACTTGTATACGCACACAAATACACTCATTTAGCCTTTATCTCAAAATGTTAAATATAAGGAAAAAAGCGTCAACA

>53634_53634_2_MIER1-WLS_MIER1_chr1_67428843_ENST00000355977_WLS_chr1_68659912_ENST00000540432_length(amino acids)=661AA_BP=151
MLNLQVQEGDMPIHELLSLYGYGSTVRLPEEDEEEEEEEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVASQD
AQEIIRPRRCKYFDTNSEVEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGICRYKENEKAPGPTTAVSYMSVKCVDARKNHHKTKWFV
PWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHE
RVPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPS
IFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAG
YWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLH
YEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGMQLPCKSR

--------------------------------------------------------------
>53634_53634_3_MIER1-WLS_MIER1_chr1_67428843_ENST00000357692_WLS_chr1_68659912_ENST00000540432_length(transcript)=2626nt_BP=921nt
GACTGGAAGAAGGAGGCGGGCGGCCCGGGCCTCAGGCCCCTCCCAGGCTCTGAGTCTCCCGGCTGCAGGCGGATGGATGGGGCTTCTTCA
GGCGGTGGCGGCAGCAGCGAAGGTGGCGGCGGCAGCAGCGGCAGCGGCTATGGTGTGGTCGCTCGATTCTCCCAGTGCCTGGCTGAGTTT
CGGACGTGGTTAAGAACCAACTGGTTGAGGTTCAATGCAGACAAGACGGATGTGATGCTGTAGAAAATGTGCATCAGATGTTTATGTTTA
ATTGGTTTACAGACTGTCTGTGGACTCTTTTCCTGTCAAATTACCAGCCATCTGTTGAATCTTCAAGTCCAGGAGGTTCAGCAACATCAG
ATGACCATGAATTTGATCCATCAGCTGACATGCTGGTTCATGATTTTGATGATGAACGAACATTAGAAGAGGAAGAAATGATGGAAGGAG
AAACAAACTTCAGCTCTGAAATAGAAGATCTTGCAAGGGAAGGCGACATGCCAATTCATGAACTTCTCAGCCTTTATGGTTATGGTAGTA
CTGTTCGACTACCTGAAGAAGATGAGGAAGAGGAAGAAGAGGAAGAAGAAGGTGAAGATGATGAAGATGCTGATAATGATGACAACAGTG
GCTGTAGTGGGGAAAATAAAGAGGAGAATATAAAGGATTCATCAGGTCAGGAGGATGAAACTCAGTCTTCCAATGATGATCCATCACAAT
CTGTTGCTTCTCAAGATGCCCAGGAAATAATCCGCCCACGTCGATGTAAATATTTTGATACAAATAGTGAAGTAGAAGAAGAATCTGAAG
AAGATGAAGATTATATTCCATCAGAAGACTGGAAAAAGGAGATTATGGTGGGCTCCATGTTTCAAGCAGAAATTCCAGTTGGCATTTGTA
GATACAAAGAAAATGAAAAAGCTCCAGGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAAGAACCATCACA
AGACAAAATGGTTCGTGCCTTGGGGACCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAATTGAAGCCAATG
ACATCGTGTTTTCTGTTCACATTCCCCTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCAGCTGGACATTG
CCTTCAAGCTAAACAACCAAATCAGAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTGCTGAGTGGA
CTGAAATGGCCCATGAAAGAGTACCACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTTACTATGAAT
GTGATGTCCTTCCTTTCATGGAAATTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGAAGAAGAAAA
TCAATGTGGGAATTGGGGAGATAAAGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTGCCATGAAGA
CCTTCCTTACGCCCAGCATCTTCATCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTCTGGAAAAAG
TCATCTTTGCCCTTGGGATTTCCATGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGATGCTGCTGT
TTGGTGACATCCGACAGGGCATCTTCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATCAGCACGAGC
GGAACCACATCGCAGGGTATTGGAAGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGGG
TACAACTCACGAATCCCTTCTACAGTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTGGAATCTGCC
TCTGCCTCTACTTCCTGTTTCTATGCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAGCTATGAGCA
AAGTCCGGCGGCTACACTATGAGGGGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGACTGTCATCT
TCTTCATCGTTAGTCAGGTAACGGAAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAGGCATCTATG
GGATGTGGAATCTGTATGTCTTTGCTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATGGAATGCAAC
TCCCATGTAAATCGAGGGAAGATTGTGCTTTGTTTGTTTCGGAACTTTATCAAGAATTGTTCAGCGCTTCGAAATATTCCTTCATCAATG
ACAACGCAGCTTCTGGTATTTGAGTCAACAAGGCAACACATGTTTATCAGCTTTGCATTTGCAGTTGTCACAGTCACATTGATTGTACTT
GTATACGCACACAAATACACTCATTTAGCCTTTATCTCAAAATGTTAAATATAAGGAAAAAAGCGTCAACAATAAATATTCTTTGAGTAT

>53634_53634_3_MIER1-WLS_MIER1_chr1_67428843_ENST00000357692_WLS_chr1_68659912_ENST00000540432_length(amino acids)=750AA_BP=240
MVEVQCRQDGCDAVENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPGGSATSDDHEFDPSADMLVHDFDDERTLEEEEMMEGETNFSSE
IEDLAREGDMPIHELLSLYGYGSTVRLPEEDEEEEEEEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVASQDA
QEIIRPRRCKYFDTNSEVEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGICRYKENEKAPGPTTAVSYMSVKCVDARKNHHKTKWFVP
WGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHER
VPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSI
FIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGY
WKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHY
EGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGMQLPCKSRE

--------------------------------------------------------------
>53634_53634_4_MIER1-WLS_MIER1_chr1_67428843_ENST00000371014_WLS_chr1_68659912_ENST00000540432_length(transcript)=2547nt_BP=842nt
CTGGAAGAAGGAGGCGGGCGGCCCGGGCCTCAGGCCCCTCCCAGGCTCTGAGTCTCCCGGCTGCAGGCGGATGGATGGGGCTTCTTCAGG
CGGTGGCGGCAGCAGCGAAGGTGGCGGCGGCAGCAGCGGCAGCGGCTATGGTGTGGTCGCTCGATTCTCCCAGTGCCTGGCTGAGTTTCG
GACGTGGTTAAGAACCAACTGGTTGAGGTTCAATGCAGACAAGACGGATGTGATGCTGCCATCTGTTGAATCTTCAAGTCCAGGAGGTTC
AGCAACATCAGATGACCATGAATTTGATCCATCAGCTGACATGCTGGTTCATGATTTTGATGATGAACGAACATTAGAAGAGGAAGAAAT
GATGGAAGGAGAAACAAACTTCAGCTCTGAAATAGAAGATCTTGCAAGGGAAGGCGACATGCCAATTCATGAACTTCTCAGCCTTTATGG
TTATGGTAGTACTGTTCGACTACCTGAAGAAGATGAGGAAGAGGAAGAAGAGGAAGAAGAAGGTGAAGATGATGAAGATGCTGATAATGA
TGACAACAGTGGCTGTAGTGGGGAAAATAAAGAGGAGAATATAAAGGATTCATCAGGTCAGGAGGATGAAACTCAGTCTTCCAATGATGA
TCCATCACAATCTGTTGCTTCTCAAGATGCCCAGGAAATAATCCGCCCACGTCGATGTAAATATTTTGATACAAATAGTGAAGTAGAAGA
AGAATCTGAAGAAGATGAAGATTATATTCCATCAGAAGACTGGAAAAAGGAGATTATGGTGGGCTCCATGTTTCAAGCAGAAATTCCAGT
TGGCATTTGTAGATACAAAGAAAATGAAAAAGCTCCAGGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAA
GAACCATCACAAGACAAAATGGTTCGTGCCTTGGGGACCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAAT
TGAAGCCAATGACATCGTGTTTTCTGTTCACATTCCCCTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCA
GCTGGACATTGCCTTCAAGCTAAACAACCAAATCAGAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTT
TGCTGAGTGGACTGAAATGGCCCATGAAAGAGTACCACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCG
TTACTATGAATGTGATGTCCTTCCTTTCATGGAAATTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGA
GAAGAAGAAAATCAATGTGGGAATTGGGGAGATAAAGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTT
TGCCATGAAGACCTTCCTTACGCCCAGCATCTTCATCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCT
TCTGGAAAAAGTCATCTTTGCCCTTGGGATTTCCATGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTG
GATGCTGCTGTTTGGTGACATCCGACAGGGCATCTTCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGA
TCAGCACGAGCGGAACCACATCGCAGGGTATTGGAAGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTG
TGAGAGAGGGGTACAACTCACGAATCCCTTCTACAGTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGC
TGGAATCTGCCTCTGCCTCTACTTCCTGTTTCTATGCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCC
AGCTATGAGCAAAGTCCGGCGGCTACACTATGAGGGGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCAT
GACTGTCATCTTCTTCATCGTTAGTCAGGTAACGGAAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCAC
AGGCATCTATGGGATGTGGAATCTGTATGTCTTTGCTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAA
TGGAATGCAACTCCCATGTAAATCGAGGGAAGATTGTGCTTTGTTTGTTTCGGAACTTTATCAAGAATTGTTCAGCGCTTCGAAATATTC
CTTCATCAATGACAACGCAGCTTCTGGTATTTGAGTCAACAAGGCAACACATGTTTATCAGCTTTGCATTTGCAGTTGTCACAGTCACAT
TGATTGTACTTGTATACGCACACAAATACACTCATTTAGCCTTTATCTCAAAATGTTAAATATAAGGAAAAAAGCGTCAACAATAAATAT

>53634_53634_4_MIER1-WLS_MIER1_chr1_67428843_ENST00000371014_WLS_chr1_68659912_ENST00000540432_length(amino acids)=767AA_BP=257
MDGASSGGGGSSEGGGGSSGSGYGVVARFSQCLAEFRTWLRTNWLRFNADKTDVMLPSVESSSPGGSATSDDHEFDPSADMLVHDFDDER
TLEEEEMMEGETNFSSEIEDLAREGDMPIHELLSLYGYGSTVRLPEEDEEEEEEEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDE
TQSSNDDPSQSVASQDAQEIIRPRRCKYFDTNSEVEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGICRYKENEKAPGPTTAVSYMSV
KCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSL
AYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNG
GFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIF
CGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNIS
GKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKN

--------------------------------------------------------------
>53634_53634_5_MIER1-WLS_MIER1_chr1_67428843_ENST00000371016_WLS_chr1_68659912_ENST00000540432_length(transcript)=2621nt_BP=916nt
CTGGAAGAAGGAGGCGGGCGGCCCGGGCCTCAGGCCCCTCCCAGGCTCTGAGTCTCCCGGCTGCAGGCGGATGGATGGGGCTTCTTCAGG
CGGTGGCGGCAGCAGCGAAGGTGGCGGCGGCAGCAGCGGCAGCGGCTATGGTGTGGTCGCTCGATTCTCCCAGTGCCTGGCTGAGTTTCG
GACGTGGTTAAGAACCAACTGGTTGAGGTTCAATGCAGACAAGACGGATGTGATGCTGAAAATGTGCATCAGATGTTTATGTTTAATTGG
TTTACAGACTGTCTGTGGACTCTTTTCCTGTCAAATTACCAGCCATCTGTTGAATCTTCAAGTCCAGGAGGTTCAGCAACATCAGATGAC
CATGAATTTGATCCATCAGCTGACATGCTGGTTCATGATTTTGATGATGAACGAACATTAGAAGAGGAAGAAATGATGGAAGGAGAAACA
AACTTCAGCTCTGAAATAGAAGATCTTGCAAGGGAAGGCGACATGCCAATTCATGAACTTCTCAGCCTTTATGGTTATGGTAGTACTGTT
CGACTACCTGAAGAAGATGAGGAAGAGGAAGAAGAGGAAGAAGAAGGTGAAGATGATGAAGATGCTGATAATGATGACAACAGTGGCTGT
AGTGGGGAAAATAAAGAGGAGAATATAAAGGATTCATCAGGTCAGGAGGATGAAACTCAGTCTTCCAATGATGATCCATCACAATCTGTT
GCTTCTCAAGATGCCCAGGAAATAATCCGCCCACGTCGATGTAAATATTTTGATACAAATAGTGAAGTAGAAGAAGAATCTGAAGAAGAT
GAAGATTATATTCCATCAGAAGACTGGAAAAAGGAGATTATGGTGGGCTCCATGTTTCAAGCAGAAATTCCAGTTGGCATTTGTAGATAC
AAAGAAAATGAAAAAGCTCCAGGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAAGAACCATCACAAGACA
AAATGGTTCGTGCCTTGGGGACCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAATTGAAGCCAATGACATC
GTGTTTTCTGTTCACATTCCCCTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCAGCTGGACATTGCCTTC
AAGCTAAACAACCAAATCAGAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTGCTGAGTGGACTGAA
ATGGCCCATGAAAGAGTACCACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTTACTATGAATGTGAT
GTCCTTCCTTTCATGGAAATTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGAAGAAGAAAATCAAT
GTGGGAATTGGGGAGATAAAGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTGCCATGAAGACCTTC
CTTACGCCCAGCATCTTCATCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTCTGGAAAAAGTCATC
TTTGCCCTTGGGATTTCCATGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGATGCTGCTGTTTGGT
GACATCCGACAGGGCATCTTCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATCAGCACGAGCGGAAC
CACATCGCAGGGTATTGGAAGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGGGTACAA
CTCACGAATCCCTTCTACAGTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTGGAATCTGCCTCTGC
CTCTACTTCCTGTTTCTATGCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAGCTATGAGCAAAGTC
CGGCGGCTACACTATGAGGGGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGACTGTCATCTTCTTC
ATCGTTAGTCAGGTAACGGAAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAGGCATCTATGGGATG
TGGAATCTGTATGTCTTTGCTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATGGAATGCAACTCCCA
TGTAAATCGAGGGAAGATTGTGCTTTGTTTGTTTCGGAACTTTATCAAGAATTGTTCAGCGCTTCGAAATATTCCTTCATCAATGACAAC
GCAGCTTCTGGTATTTGAGTCAACAAGGCAACACATGTTTATCAGCTTTGCATTTGCAGTTGTCACAGTCACATTGATTGTACTTGTATA
CGCACACAAATACACTCATTTAGCCTTTATCTCAAAATGTTAAATATAAGGAAAAAAGCGTCAACAATAAATATTCTTTGAGTATTGTCT

>53634_53634_5_MIER1-WLS_MIER1_chr1_67428843_ENST00000371016_WLS_chr1_68659912_ENST00000540432_length(amino acids)=749AA_BP=239
MVEVQCRQDGCDAENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPGGSATSDDHEFDPSADMLVHDFDDERTLEEEEMMEGETNFSSEI
EDLAREGDMPIHELLSLYGYGSTVRLPEEDEEEEEEEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVASQDAQ
EIIRPRRCKYFDTNSEVEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGICRYKENEKAPGPTTAVSYMSVKCVDARKNHHKTKWFVPW
GPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERV
PRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIF
IIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYW
KQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYE
GLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGMQLPCKSRED

--------------------------------------------------------------
>53634_53634_6_MIER1-WLS_MIER1_chr1_67428843_ENST00000371018_WLS_chr1_68659912_ENST00000540432_length(transcript)=2685nt_BP=980nt
AGGAGGGCGGAGGCGGAGGGGAGGGCAGAGGGTTGGTGGAGCTGGAGGAAGCTCCGGACGACGACTGGAAGAAGGAGGCGGGCGGCCCGG
GCCTCAGGCCCCTCCCAGGCTCTGAGTCTCCCGGCTGCAGGCGGATGGATGGGGCTTCTTCAGGCGGTGGCGGCAGCAGCGAAGGTGGCG
GCGGCAGCAGCGGCAGCGGCTATGGTGTGGTCGCTCGATTCTCCCAGTGCCTGGCTGAGTTTCGGACGTGGTTAAGAACCAACTGGTTGA
GGTTCAATGCAGACAAGACGGATGTGATGCTGAAAATGTGCATCAGATGTTTATGTTTAATTGGTTTACAGACTGTCTGTGGACTCTTTT
CCTGTCAAATTACCAGCCATCTGTTGAATCTTCAAGTCCAGGAGGTTCAGCAACATCAGATGACCATGAATTTGATCCATCAGCTGACAT
GCTGGTTCATGATTTTGATGATGAACGAACATTAGAAGAGGAAGAAATGATGGAAGGAGAAACAAACTTCAGCTCTGAAATAGAAGATCT
TGCAAGGGAAGGCGACATGCCAATTCATGAACTTCTCAGCCTTTATGGTTATGGTAGTACTGTTCGACTACCTGAAGAAGATGAGGAAGA
GGAAGAAGAGGAAGAAGAAGGTGAAGATGATGAAGATGCTGATAATGATGACAACAGTGGCTGTAGTGGGGAAAATAAAGAGGAGAATAT
AAAGGATTCATCAGGTCAGGAGGATGAAACTCAGTCTTCCAATGATGATCCATCACAATCTGTTGCTTCTCAAGATGCCCAGGAAATAAT
CCGCCCACGTCGATGTAAATATTTTGATACAAATAGTGAAGTAGAAGAAGAATCTGAAGAAGATGAAGATTATATTCCATCAGAAGACTG
GAAAAAGGAGATTATGGTGGGCTCCATGTTTCAAGCAGAAATTCCAGTTGGCATTTGTAGATACAAAGAAAATGAAAAAGCTCCAGGGCC
CACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAAGAACCATCACAAGACAAAATGGTTCGTGCCTTGGGGACCCAA
TCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAATTGAAGCCAATGACATCGTGTTTTCTGTTCACATTCCCCTCCC
CCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCAGCTGGACATTGCCTTCAAGCTAAACAACCAAATCAGAGAAAA
TGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTGCTGAGTGGACTGAAATGGCCCATGAAAGAGTACCACGGAA
ACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTTACTATGAATGTGATGTCCTTCCTTTCATGGAAATTGGGTC
TGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGAAGAAGAAAATCAATGTGGGAATTGGGGAGATAAAGGATAT
CCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTGCCATGAAGACCTTCCTTACGCCCAGCATCTTCATCATTAT
GGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTCTGGAAAAAGTCATCTTTGCCCTTGGGATTTCCATGACCTT
TATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGATGCTGCTGTTTGGTGACATCCGACAGGGCATCTTCTATGC
GATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATCAGCACGAGCGGAACCACATCGCAGGGTATTGGAAGCAAGT
CGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGGGTACAACTCACGAATCCCTTCTACAGTATCTG
GACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTGGAATCTGCCTCTGCCTCTACTTCCTGTTTCTATGCTTCAT
GGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAGCTATGAGCAAAGTCCGGCGGCTACACTATGAGGGGCTAAT
TTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGACTGTCATCTTCTTCATCGTTAGTCAGGTAACGGAAGGCCA
TTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAGGCATCTATGGGATGTGGAATCTGTATGTCTTTGCTCTGAT
GTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATGGAATGCAACTCCCATGTAAATCGAGGGAAGATTGTGCTTT
GTTTGTTTCGGAACTTTATCAAGAATTGTTCAGCGCTTCGAAATATTCCTTCATCAATGACAACGCAGCTTCTGGTATTTGAGTCAACAA
GGCAACACATGTTTATCAGCTTTGCATTTGCAGTTGTCACAGTCACATTGATTGTACTTGTATACGCACACAAATACACTCATTTAGCCT

>53634_53634_6_MIER1-WLS_MIER1_chr1_67428843_ENST00000371018_WLS_chr1_68659912_ENST00000540432_length(amino acids)=749AA_BP=239
MVEVQCRQDGCDAENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPGGSATSDDHEFDPSADMLVHDFDDERTLEEEEMMEGETNFSSEI
EDLAREGDMPIHELLSLYGYGSTVRLPEEDEEEEEEEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVASQDAQ
EIIRPRRCKYFDTNSEVEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGICRYKENEKAPGPTTAVSYMSVKCVDARKNHHKTKWFVPW
GPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERV
PRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIF
IIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYW
KQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYE
GLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGMQLPCKSRED

--------------------------------------------------------------
>53634_53634_7_MIER1-WLS_MIER1_chr1_67428843_ENST00000401041_WLS_chr1_68659912_ENST00000540432_length(transcript)=2547nt_BP=842nt
CTGGAAGAAGGAGGCGGGCGGCCCGGGCCTCAGGCCCCTCCCAGGCTCTGAGTCTCCCGGCTGCAGGCGGATGGATGGGGCTTCTTCAGG
CGGTGGCGGCAGCAGCGAAGGTGGCGGCGGCAGCAGCGGCAGCGGCTATGGTGTGGTCGCTCGATTCTCCCAGTGCCTGGCTGAGTTTCG
GACGTGGTTAAGAACCAACTGGTTGAGGTTCAATGCAGACAAGACGGATGTGATGCTGCCATCTGTTGAATCTTCAAGTCCAGGAGGTTC
AGCAACATCAGATGACCATGAATTTGATCCATCAGCTGACATGCTGGTTCATGATTTTGATGATGAACGAACATTAGAAGAGGAAGAAAT
GATGGAAGGAGAAACAAACTTCAGCTCTGAAATAGAAGATCTTGCAAGGGAAGGCGACATGCCAATTCATGAACTTCTCAGCCTTTATGG
TTATGGTAGTACTGTTCGACTACCTGAAGAAGATGAGGAAGAGGAAGAAGAGGAAGAAGAAGGTGAAGATGATGAAGATGCTGATAATGA
TGACAACAGTGGCTGTAGTGGGGAAAATAAAGAGGAGAATATAAAGGATTCATCAGGTCAGGAGGATGAAACTCAGTCTTCCAATGATGA
TCCATCACAATCTGTTGCTTCTCAAGATGCCCAGGAAATAATCCGCCCACGTCGATGTAAATATTTTGATACAAATAGTGAAGTAGAAGA
AGAATCTGAAGAAGATGAAGATTATATTCCATCAGAAGACTGGAAAAAGGAGATTATGGTGGGCTCCATGTTTCAAGCAGAAATTCCAGT
TGGCATTTGTAGATACAAAGAAAATGAAAAAGCTCCAGGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAA
GAACCATCACAAGACAAAATGGTTCGTGCCTTGGGGACCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAAT
TGAAGCCAATGACATCGTGTTTTCTGTTCACATTCCCCTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCA
GCTGGACATTGCCTTCAAGCTAAACAACCAAATCAGAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTT
TGCTGAGTGGACTGAAATGGCCCATGAAAGAGTACCACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCG
TTACTATGAATGTGATGTCCTTCCTTTCATGGAAATTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGA
GAAGAAGAAAATCAATGTGGGAATTGGGGAGATAAAGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTT
TGCCATGAAGACCTTCCTTACGCCCAGCATCTTCATCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCT
TCTGGAAAAAGTCATCTTTGCCCTTGGGATTTCCATGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTG
GATGCTGCTGTTTGGTGACATCCGACAGGGCATCTTCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGA
TCAGCACGAGCGGAACCACATCGCAGGGTATTGGAAGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTG
TGAGAGAGGGGTACAACTCACGAATCCCTTCTACAGTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGC
TGGAATCTGCCTCTGCCTCTACTTCCTGTTTCTATGCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCC
AGCTATGAGCAAAGTCCGGCGGCTACACTATGAGGGGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCAT
GACTGTCATCTTCTTCATCGTTAGTCAGGTAACGGAAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCAC
AGGCATCTATGGGATGTGGAATCTGTATGTCTTTGCTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAA
TGGAATGCAACTCCCATGTAAATCGAGGGAAGATTGTGCTTTGTTTGTTTCGGAACTTTATCAAGAATTGTTCAGCGCTTCGAAATATTC
CTTCATCAATGACAACGCAGCTTCTGGTATTTGAGTCAACAAGGCAACACATGTTTATCAGCTTTGCATTTGCAGTTGTCACAGTCACAT
TGATTGTACTTGTATACGCACACAAATACACTCATTTAGCCTTTATCTCAAAATGTTAAATATAAGGAAAAAAGCGTCAACAATAAATAT

>53634_53634_7_MIER1-WLS_MIER1_chr1_67428843_ENST00000401041_WLS_chr1_68659912_ENST00000540432_length(amino acids)=767AA_BP=257
MDGASSGGGGSSEGGGGSSGSGYGVVARFSQCLAEFRTWLRTNWLRFNADKTDVMLPSVESSSPGGSATSDDHEFDPSADMLVHDFDDER
TLEEEEMMEGETNFSSEIEDLAREGDMPIHELLSLYGYGSTVRLPEEDEEEEEEEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDE
TQSSNDDPSQSVASQDAQEIIRPRRCKYFDTNSEVEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGICRYKENEKAPGPTTAVSYMSV
KCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSL
AYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNG
GFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIF
CGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNIS
GKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKN

--------------------------------------------------------------
>53634_53634_8_MIER1-WLS_MIER1_chr1_67428843_ENST00000401042_WLS_chr1_68659912_ENST00000540432_length(transcript)=2467nt_BP=762nt
GCGGCTCCTGCGCGTTCCCGCCGAGGCAGTGGCGGCGGGAGCGGCAGAGACGGCAGCGGCCGGAGTCCCGTTGCTGAGTCTCACATCCGG
GTTCTGGCCGTGACCCAGCTGCGGCCGCCGCGGAGATGTGACCCGGCAGTACGGCAAATATGGCGGAGCCATCTGTTGAATCTTCAAGTC
CAGGAGGTTCAGCAACATCAGATGACCATGAATTTGATCCATCAGCTGACATGCTGGTTCATGATTTTGATGATGAACGAACATTAGAAG
AGGAAGAAATGATGGAAGGAGAAACAAACTTCAGCTCTGAAATAGAAGATCTTGCAAGGGAAGGCGACATGCCAATTCATGAACTTCTCA
GCCTTTATGGTTATGGTAGTACTGTTCGACTACCTGAAGAAGATGAGGAAGAGGAAGAAGAGGAAGAAGAAGGTGAAGATGATGAAGATG
CTGATAATGATGACAACAGTGGCTGTAGTGGGGAAAATAAAGAGGAGAATATAAAGGATTCATCAGGTCAGGAGGATGAAACTCAGTCTT
CCAATGATGATCCATCACAATCTGTTGCTTCTCAAGATGCCCAGGAAATAATCCGCCCACGTCGATGTAAATATTTTGATACAAATAGTG
AAGTAGAAGAAGAATCTGAAGAAGATGAAGATTATATTCCATCAGAAGACTGGAAAAAGGAGATTATGGTGGGCTCCATGTTTCAAGCAG
AAATTCCAGTTGGCATTTGTAGATACAAAGAAAATGAAAAAGCTCCAGGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGG
ATGCCCGTAAGAACCATCACAAGACAAAATGGTTCGTGCCTTGGGGACCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTC
CAAGGGAAATTGAAGCCAATGACATCGTGTTTTCTGTTCACATTCCCCTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGT
TTATCCTGCAGCTGGACATTGCCTTCAAGCTAAACAACCAAATCAGAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTG
ATGACGCGTTTGCTGAGTGGACTGAAATGGCCCATGAAAGAGTACCACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGC
ATGAGGGCCGTTACTATGAATGTGATGTCCTTCCTTTCATGGAAATTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGC
CTGTGAATGAGAAGAAGAAAATCAATGTGGGAATTGGGGAGATAAAGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCA
AGGTGTGGTTTGCCATGAAGACCTTCCTTACGCCCAGCATCTTCATCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGAC
CCCCAGTGCTTCTGGAAAAAGTCATCTTTGCCCTTGGGATTTCCATGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTG
ACTGGACCTGGATGCTGCTGTTTGGTGACATCCGACAGGGCATCTTCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGC
ACATGATGGATCAGCACGAGCGGAACCACATCGCAGGGTATTGGAAGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATAT
TTGACATGTGTGAGAGAGGGGTACAACTCACGAATCCCTTCTACAGTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCA
TCATCGTGGCTGGAATCTGCCTCTGCCTCTACTTCCTGTTTCTATGCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGT
CCAGCCTGCCAGCTATGAGCAAAGTCCGGCGGCTACACTATGAGGGGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCT
GCGCTGCCATGACTGTCATCTTCTTCATCGTTAGTCAGGTAACGGAAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTG
CCTTTTTCACAGGCATCTATGGGATGTGGAATCTGTATGTCTTTGCTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAG
ACCAGTCCAATGGAATGCAACTCCCATGTAAATCGAGGGAAGATTGTGCTTTGTTTGTTTCGGAACTTTATCAAGAATTGTTCAGCGCTT
CGAAATATTCCTTCATCAATGACAACGCAGCTTCTGGTATTTGAGTCAACAAGGCAACACATGTTTATCAGCTTTGCATTTGCAGTTGTC
ACAGTCACATTGATTGTACTTGTATACGCACACAAATACACTCATTTAGCCTTTATCTCAAAATGTTAAATATAAGGAAAAAAGCGTCAA

>53634_53634_8_MIER1-WLS_MIER1_chr1_67428843_ENST00000401042_WLS_chr1_68659912_ENST00000540432_length(amino acids)=714AA_BP=204
MAEPSVESSSPGGSATSDDHEFDPSADMLVHDFDDERTLEEEEMMEGETNFSSEIEDLAREGDMPIHELLSLYGYGSTVRLPEEDEEEEE
EEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVASQDAQEIIRPRRCKYFDTNSEVEEESEEDEDYIPSEDWKK
EIMVGSMFQAEIPVGICRYKENEKAPGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHM
EMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVA
HKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFIN
IPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTT
DIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MIER1-WLS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneWLSchr1:67428843chr1:68659912ENST00000262348012101_23235.333333333333336542.0Wnt proteins
TgeneWLSchr1:67428843chr1:68659912ENST00000354777012101_2320544.0Wnt proteins
TgeneWLSchr1:67428843chr1:68659912ENST00000370976011101_2320451.0Wnt proteins


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMIER1chr1:67428843chr1:68659912ENST00000355356+713180_284204.33333333333334513.0HDAC1
HgeneMIER1chr1:67428843chr1:68659912ENST00000355977+714180_284141.33333333333334371.0HDAC1
HgeneMIER1chr1:67428843chr1:68659912ENST00000357692+915180_284221.33333333333334530.0HDAC1
HgeneMIER1chr1:67428843chr1:68659912ENST00000371014+815180_284257.3333333333333487.0HDAC1
HgeneMIER1chr1:67428843chr1:68659912ENST00000371016+916180_284221.33333333333334451.0HDAC1
HgeneMIER1chr1:67428843chr1:68659912ENST00000371018+916180_284221.33333333333334471.0HDAC1
HgeneMIER1chr1:67428843chr1:68659912ENST00000401041+814180_284257.3333333333333566.0HDAC1
HgeneMIER1chr1:67428843chr1:68659912ENST00000401042+714180_284204.33333333333334434.0HDAC1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MIER1-WLS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MIER1-WLS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource