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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MIER2-CDK5RAP1 (FusionGDB2 ID:53635)

Fusion Gene Summary for MIER2-CDK5RAP1

Fusion gene summary

Fusion gene information	Fusion gene name: MIER2-CDK5RAP1
	Fusion gene ID: 53635
		Hgene	Tgene
	Gene symbol	MIER2	CDK5RAP1
	Gene ID	54531	51654
	Gene name	MIER family member 2	CDK5 regulatory subunit associated protein 1
	Synonyms	KIAA1193\|Mi-er2	C20orf34\|C42\|CGI-05\|HSPC167
	Cytomap	19p13.3	20q11.21
	Type of gene	protein-coding	protein-coding
	Description	mesoderm induction early response protein 2mesoderm induction early response 1, family member 2	CDK5 regulatory subunit-associated protein 1CDK5 activator-binding protein C42
	Modification date	20200313	20200313
	UniProtAcc	Q8N344	Q96SZ6
	Ensembl transtripts involved in fusion gene	ENST00000264819, ENST00000592722,	ENST00000477105, ENST00000339269, ENST00000346416, ENST00000357886, ENST00000473997, ENST00000544843,
Fusion gene scores	* DoF score	5 X 7 X 7=245	8 X 6 X 7=336
	# samples	7	9
	** MAII score	log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MIER2 [Title/Abstract] AND CDK5RAP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MIER2(325635)-CDK5RAP1(31975339), # samples:5
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MIER2	GO:0016575	histone deacetylation	28046085
Tgene	CDK5RAP1	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	11882646

Fusion gene breakpoints across MIER2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CDK5RAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-BL-A0C8-01A	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-
ChimerDB4	BLCA	TCGA-BL-A0C8-01B	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-
ChimerDB4	BLCA	TCGA-BL-A0C8	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-

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Fusion Gene ORF analysis for MIER2-CDK5RAP1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000264819	ENST00000477105	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-
5CDS-5UTR	ENST00000264819	ENST00000477105	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-
In-frame	ENST00000264819	ENST00000339269	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-
In-frame	ENST00000264819	ENST00000339269	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-
In-frame	ENST00000264819	ENST00000346416	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-
In-frame	ENST00000264819	ENST00000346416	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-
In-frame	ENST00000264819	ENST00000357886	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-
In-frame	ENST00000264819	ENST00000357886	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-
In-frame	ENST00000264819	ENST00000473997	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-
In-frame	ENST00000264819	ENST00000473997	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-
In-frame	ENST00000264819	ENST00000544843	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-
In-frame	ENST00000264819	ENST00000544843	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-
intron-3CDS	ENST00000592722	ENST00000339269	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-
intron-3CDS	ENST00000592722	ENST00000339269	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-
intron-3CDS	ENST00000592722	ENST00000346416	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-
intron-3CDS	ENST00000592722	ENST00000346416	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-
intron-3CDS	ENST00000592722	ENST00000357886	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-
intron-3CDS	ENST00000592722	ENST00000357886	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-
intron-3CDS	ENST00000592722	ENST00000473997	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-
intron-3CDS	ENST00000592722	ENST00000473997	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-
intron-3CDS	ENST00000592722	ENST00000544843	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-
intron-3CDS	ENST00000592722	ENST00000544843	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-
intron-5UTR	ENST00000592722	ENST00000477105	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-
intron-5UTR	ENST00000592722	ENST00000477105	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264819	MIER2	chr19	325635	-	ENST00000473997	CDK5RAP1	chr20	31975339	-	2090	666	11	1885	624
ENST00000264819	MIER2	chr19	325635	-	ENST00000346416	CDK5RAP1	chr20	31975339	-	2090	666	11	1885	624
ENST00000264819	MIER2	chr19	325635	-	ENST00000339269	CDK5RAP1	chr20	31975339	-	1859	666	11	1654	547
ENST00000264819	MIER2	chr19	325635	-	ENST00000357886	CDK5RAP1	chr20	31975339	-	2132	666	11	1927	638
ENST00000264819	MIER2	chr19	325635	-	ENST00000544843	CDK5RAP1	chr20	31975339	-	1801	666	11	1402	463
ENST00000264819	MIER2	chr19	325634	-	ENST00000473997	CDK5RAP1	chr20	31975339	-	2090	666	11	1885	624
ENST00000264819	MIER2	chr19	325634	-	ENST00000346416	CDK5RAP1	chr20	31975339	-	2090	666	11	1885	624
ENST00000264819	MIER2	chr19	325634	-	ENST00000339269	CDK5RAP1	chr20	31975339	-	1859	666	11	1654	547
ENST00000264819	MIER2	chr19	325634	-	ENST00000357886	CDK5RAP1	chr20	31975339	-	2132	666	11	1927	638
ENST00000264819	MIER2	chr19	325634	-	ENST00000544843	CDK5RAP1	chr20	31975339	-	1801	666	11	1402	463

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264819	ENST00000473997	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-	0.005159637	0.9948403
ENST00000264819	ENST00000346416	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-	0.005159637	0.9948403
ENST00000264819	ENST00000339269	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-	0.005871391	0.9941286
ENST00000264819	ENST00000357886	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-	0.00481453	0.99518543
ENST00000264819	ENST00000544843	MIER2	chr19	325635	-	CDK5RAP1	chr20	31975339	-	0.003178014	0.996822
ENST00000264819	ENST00000473997	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-	0.005159637	0.9948403
ENST00000264819	ENST00000346416	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-	0.005159637	0.9948403
ENST00000264819	ENST00000339269	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-	0.005871391	0.9941286
ENST00000264819	ENST00000357886	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-	0.00481453	0.99518543
ENST00000264819	ENST00000544843	MIER2	chr19	325634	-	CDK5RAP1	chr20	31975339	-	0.003178014	0.996822

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Fusion Genomic Features for MIER2-CDK5RAP1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MIER2-CDK5RAP1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:325635/chr20:31975339)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MIER2 Q8N344	CDK5RAP1 Q96SZ6
FUNCTION: Transcriptional repressor. {ECO:0000250}.	FUNCTION: Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:22422838, PubMed:25738458, PubMed:28981754). Essential for efficient and highly accurate protein translation by the ribosome (PubMed:22422838, PubMed:25738458, PubMed:28981754). Specifically inhibits CDK5 activation by CDK5R1 (PubMed:11882646). Essential for efficient mitochondrial protein synthesis and respiratory chain; shows pathological consequences in mitochondrial disease (PubMed:25738458). {ECO:0000269\|PubMed:11882646, ECO:0000269\|PubMed:22422838, ECO:0000269\|PubMed:25738458, ECO:0000269\|PubMed:28981754}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CDK5RAP1

chr19:325634

chr20:31975339

ENST00000339269

244_512

181

511.0

Domain

Radical SAM core

Tgene

CDK5RAP1

chr19:325634

chr20:31975339

ENST00000339269

515_590

181

511.0

Domain

TRAM

Tgene

CDK5RAP1

chr19:325634

chr20:31975339

ENST00000346416

244_512

181

588.0

Domain

Radical SAM core

Tgene

CDK5RAP1

chr19:325634

chr20:31975339

ENST00000346416

515_590

181

588.0

Domain

TRAM

Tgene

CDK5RAP1

chr19:325634

chr20:31975339

ENST00000357886

244_512

181

602.0

Domain

Radical SAM core

Tgene

CDK5RAP1

chr19:325634

chr20:31975339

ENST00000357886

515_590

181

602.0

Domain

TRAM

Tgene

CDK5RAP1

chr19:325634

chr20:31975339

ENST00000544843

244_512

181

427.6666666666667

Domain

Radical SAM core

Tgene

CDK5RAP1

chr19:325634

chr20:31975339

ENST00000544843

515_590

181

427.6666666666667

Domain

TRAM

Tgene

CDK5RAP1

chr19:325635

chr20:31975339

ENST00000339269

244_512

181

511.0

Domain

Radical SAM core

Tgene

CDK5RAP1

chr19:325635

chr20:31975339

ENST00000339269

515_590

181

511.0

Domain

TRAM

Tgene

CDK5RAP1

chr19:325635

chr20:31975339

ENST00000346416

244_512

181

588.0

Domain

Radical SAM core

Tgene

CDK5RAP1

chr19:325635

chr20:31975339

ENST00000346416

515_590

181

588.0

Domain

TRAM

Tgene

CDK5RAP1

chr19:325635

chr20:31975339

ENST00000357886

244_512

181

602.0

Domain

Radical SAM core

Tgene

CDK5RAP1

chr19:325635

chr20:31975339

ENST00000357886

515_590

181

602.0

Domain

TRAM

Tgene

CDK5RAP1

chr19:325635

chr20:31975339

ENST00000544843

244_512

181

427.6666666666667

Domain

Radical SAM core

Tgene

CDK5RAP1

chr19:325635

chr20:31975339

ENST00000544843

515_590

181

427.6666666666667

Domain

TRAM

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MIER2

chr19:325634

chr20:31975339

ENST00000264819

195_292

218

546.0

Domain

ELM2

Hgene

MIER2

chr19:325634

chr20:31975339

ENST00000264819

297_349

218

546.0

Domain

SANT

Hgene

MIER2

chr19:325635

chr20:31975339

ENST00000264819

195_292

218

546.0

Domain

ELM2

Hgene

MIER2

chr19:325635

chr20:31975339

ENST00000264819

297_349

218

546.0

Domain

SANT

Tgene

CDK5RAP1

chr19:325634

chr20:31975339

ENST00000339269

100_220

181

511.0

Domain

MTTase N-terminal

Tgene

CDK5RAP1

chr19:325634

chr20:31975339

ENST00000346416

100_220

181

588.0

Domain

MTTase N-terminal

Tgene

CDK5RAP1

chr19:325634

chr20:31975339

ENST00000357886

100_220

181

602.0

Domain

MTTase N-terminal

Tgene

CDK5RAP1

chr19:325634

chr20:31975339

ENST00000544843

100_220

181

427.6666666666667

Domain

MTTase N-terminal

Tgene

CDK5RAP1

chr19:325635

chr20:31975339

ENST00000339269

100_220

181

511.0

Domain

MTTase N-terminal

Tgene

CDK5RAP1

chr19:325635

chr20:31975339

ENST00000346416

100_220

181

588.0

Domain

MTTase N-terminal

Tgene

CDK5RAP1

chr19:325635

chr20:31975339

ENST00000357886

100_220

181

602.0

Domain

MTTase N-terminal

Tgene

CDK5RAP1

chr19:325635

chr20:31975339

ENST00000544843

100_220

181

427.6666666666667

Domain

MTTase N-terminal

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Fusion Gene Sequence for MIER2-CDK5RAP1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>53635_53635_1_MIER2-CDK5RAP1_MIER2_chr19_325634_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000339269_length(transcript)=1859nt_BP=666nt
CACACACGGCCATGGCGGAGGCCTCCTCGCTGGGGAGGCAGAGTCCTCGCGTGGTCTCCTGCCTCGAGCACAGCCTGTGCCCAGGGGAGC
CGGGCTTGCAGACAACAGCAGTGGTGTCCATGGGCTCTGGAGACCATCAGTTCAACCTCGCAGAGATCCTGTCACAGAACTACAGTGTTA
GGGGGGAGTGCGAGGAGGCCTCGAGGTGCCCAGACAAGCCCAAGGAGGAGCTGGAGAAGGACTTCATCTCCCAGAGCAACGACATGCCCT
TTGATGAGCTGCTTGCGCTCTATGGCTACGAGGCGTCAGACCCCATTTCAGACCGGGAGAGTGAGGGTGGTGACGTGGCCCCGAACCTCC
CAGACATGACCCTGGACAAAGAACAAATAGCGAAGGATTTGCTTTCAGGGGAAGAAGAGGAAGAGACGCAATCATCTGCTGACGACCTCA
CCCCGTCCGTGACCTCCCACGAGGCCTCCGACCTCTTCCCTAACCGGAGTGGATCTCGTTTCCTGGCTGATGAAGACAGAGAGCCTGGCT
CTTCTGCCTCCTCCGACACCGAGGAGGACTCTCTTCCTGCCAACAAATGTAAGAAGGAGATCATGGTGGGACCTCAGTTCCAAGCTGACC
TCAGCAACCTGCACTTGAACCGGCACTGTGAGAAGAGCTGCATGGCTGAGAGGTTGAAGGAGGAGATTCTCAACAGAGAGAAAATGGTAG
ATATTTTGGCTGGTCCTGATGCCTACCGGGACCTTCCCCGGCTGCTGGCTGTTGCTGAGTCGGGCCAGCAAGCTGCCAACGTGCTGCTCT
CTCTGGACGAGACCTATGCTGATGTCATGCCAGTCCAGACAAGCGCCAGTGCCACGTCTGCCTTTGTGTCAATCATGCGAGGCTGTGACA
ACATGTGTAGCTACTGCATTGTTCCTTTCACCCGGGGCAGGGAGAGGAGTCGGCCTATTGCCTCCATTCTAGAGGAAGTGAAGAAGCTTT
CTGAGCAGGTTCTGCAGCTGATTCATGAGAGAGATAACATCTGTAAACAGATCCACCTGCCAGCCCAGAGTGGAAGCAGCCGTGTGTTGG
AGGCCATGCGGAGGGGATATTCAAGAGAAGCTTATGTGGAGTTAGTTCACCATATTAGAGAATCTATTCCAGGTGTGAGCCTCAGCAGCG
ATTTCATTGCTGGCTTTTGTGGTGAGACGGAGGAAGATCACGTCCAGACAGTCTCTTTGCTCCGGGAAGTTCAGTACAACATGGGCTTCC
TCTTTGCCTACAGCATGAGACAGAAGACACGGGCATATCATAGGCTGAAGGATGATGTCCCGGAAGAGGTAAAATTAAGGCGTTTGGAGG
AACTCATCACTATCTTCCGAGAAGAAGCAACAAAAGCCAATCAGACCTCTGTGGGCTGTACCCAGTTGGTGCTAGTGGAAGGGCTCAGTA
AACGCTCTGCCACTGACCTGTGTGGCAGGAATGATGGAAACCTTAAGGTGATCTTCCCTGATGCAGAGATGGAGGATGTCAATAACCCTG
GGCTCAGGGTCAGAGCCCAGCCTGGGGACTATGTGCTGGTGAAGATCACCTCAGCCAGTTCTCAGACACTTAGGGGACATGTTCTCTGCA
GGACCACTCTGAGGGACTCTTCTGCATATTGCTGACCTGAGAGGATGGCCTCAGAGCTGACTTGGGCAATCCTCCCCAACAGGAAGGGGA
GACATTGCCTGCCACTGAGGAAACAGGTCATGAAGGTGGAGATAAGCTGCAAGGGGCGAAGCAACTTTATGTCAGTGGAAAACGTGTCTC

>53635_53635_1_MIER2-CDK5RAP1_MIER2_chr19_325634_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000339269_length(amino acids)=547AA_BP=219
MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGECEEASRCPDKPKEELEKDFISQSNDMPFDEL
LALYGYEASDPISDRESEGGDVAPNLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSAS
SDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKSCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDE
TYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQVLQLIHERDNICKQIHLPAQSGSSRVLEAMR
RGYSREAYVELVHHIRESIPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELIT
IFREEATKANQTSVGCTQLVLVEGLSKRSATDLCGRNDGNLKVIFPDAEMEDVNNPGLRVRAQPGDYVLVKITSASSQTLRGHVLCRTTL

--------------------------------------------------------------
>53635_53635_2_MIER2-CDK5RAP1_MIER2_chr19_325634_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000346416_length(transcript)=2090nt_BP=666nt
CACACACGGCCATGGCGGAGGCCTCCTCGCTGGGGAGGCAGAGTCCTCGCGTGGTCTCCTGCCTCGAGCACAGCCTGTGCCCAGGGGAGC
CGGGCTTGCAGACAACAGCAGTGGTGTCCATGGGCTCTGGAGACCATCAGTTCAACCTCGCAGAGATCCTGTCACAGAACTACAGTGTTA
GGGGGGAGTGCGAGGAGGCCTCGAGGTGCCCAGACAAGCCCAAGGAGGAGCTGGAGAAGGACTTCATCTCCCAGAGCAACGACATGCCCT
TTGATGAGCTGCTTGCGCTCTATGGCTACGAGGCGTCAGACCCCATTTCAGACCGGGAGAGTGAGGGTGGTGACGTGGCCCCGAACCTCC
CAGACATGACCCTGGACAAAGAACAAATAGCGAAGGATTTGCTTTCAGGGGAAGAAGAGGAAGAGACGCAATCATCTGCTGACGACCTCA
CCCCGTCCGTGACCTCCCACGAGGCCTCCGACCTCTTCCCTAACCGGAGTGGATCTCGTTTCCTGGCTGATGAAGACAGAGAGCCTGGCT
CTTCTGCCTCCTCCGACACCGAGGAGGACTCTCTTCCTGCCAACAAATGTAAGAAGGAGATCATGGTGGGACCTCAGTTCCAAGCTGACC
TCAGCAACCTGCACTTGAACCGGCACTGTGAGAAGAGCTGCATGGCTGAGAGGTTGAAGGAGGAGATTCTCAACAGAGAGAAAATGGTAG
ATATTTTGGCTGGTCCTGATGCCTACCGGGACCTTCCCCGGCTGCTGGCTGTTGCTGAGTCGGGCCAGCAAGCTGCCAACGTGCTGCTCT
CTCTGGACGAGACCTATGCTGATGTCATGCCAGTCCAGACAAGCGCCAGTGCCACGTCTGCCTTTGTGTCAATCATGCGAGGCTGTGACA
ACATGTGTAGCTACTGCATTGTTCCTTTCACCCGGGGCAGGGAGAGGAGTCGGCCTATTGCCTCCATTCTAGAGGAAGTGAAGAAGCTTT
CTGAGCAGGGGCTGAAAGAAGTGACACTTCTTGGTCAGAATGTTAATAGTTTTCGGGACAATTCGGAGGTCCAGTTCAACAGTGCAGTGC
CTACCAATCTCAGTCGTGGCTTTACCACCAACTATAAAACCAAGCAAGGAGGACTTCGTTTTGCTCATCTTCTGGATCAGGTCTCCAGAG
TAGATCCTGAAATGAGGATCCGTTTTACCTCTCCCCACCCCAAGGATTTTCCTGATGAGGTTCTGCAGCTGATTCATGAGAGAGATAACA
TCTGTAAACAGATCCACCTGCCAGCCCAGAGTGGAAGCAGCCGTGTGTTGGAGGCCATGCGGAGGGGATATTCAAGAGAAGCTTATGTGG
AGTTAGTTCACCATATTAGAGAATCTATTCCAGGTGTGAGCCTCAGCAGCGATTTCATTGCTGGCTTTTGTGGTGAGACGGAGGAAGATC
ACGTCCAGACAGTCTCTTTGCTCCGGGAAGTTCAGTACAACATGGGCTTCCTCTTTGCCTACAGCATGAGACAGAAGACACGGGCATATC
ATAGGCTGAAGGATGATGTCCCGGAAGAGGTAAAATTAAGGCGTTTGGAGGAACTCATCACTATCTTCCGAGAAGAAGCAACAAAAGCCA
ATCAGACCTCTGTGGGCTGTACCCAGTTGGTGCTAGTGGAAGGGCTCAGTAAACGCTCTGCCACTGACCTGTGTGGCAGGAATGATGGAA
ACCTTAAGGTGATCTTCCCTGATGCAGAGATGGAGGATGTCAATAACCCTGGGCTCAGGGTCAGAGCCCAGCCTGGGGACTATGTGCTGG
TGAAGATCACCTCAGCCAGTTCTCAGACACTTAGGGGACATGTTCTCTGCAGGACCACTCTGAGGGACTCTTCTGCATATTGCTGACCTG
AGAGGATGGCCTCAGAGCTGACTTGGGCAATCCTCCCCAACAGGAAGGGGAGACATTGCCTGCCACTGAGGAAACAGGTCATGAAGGTGG
AGATAAGCTGCAAGGGGCGAAGCAACTTTATGTCAGTGGAAAACGTGTCTCTTTAAAGCTGCTATGTGAACAGCTTTTACAGTCATTAAA

>53635_53635_2_MIER2-CDK5RAP1_MIER2_chr19_325634_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000346416_length(amino acids)=624AA_BP=219
MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGECEEASRCPDKPKEELEKDFISQSNDMPFDEL
LALYGYEASDPISDRESEGGDVAPNLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSAS
SDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKSCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDE
TYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNL
SRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAMRRGYSREAYVELVH
HIRESIPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITIFREEATKANQTS

--------------------------------------------------------------
>53635_53635_3_MIER2-CDK5RAP1_MIER2_chr19_325634_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000357886_length(transcript)=2132nt_BP=666nt
CACACACGGCCATGGCGGAGGCCTCCTCGCTGGGGAGGCAGAGTCCTCGCGTGGTCTCCTGCCTCGAGCACAGCCTGTGCCCAGGGGAGC
CGGGCTTGCAGACAACAGCAGTGGTGTCCATGGGCTCTGGAGACCATCAGTTCAACCTCGCAGAGATCCTGTCACAGAACTACAGTGTTA
GGGGGGAGTGCGAGGAGGCCTCGAGGTGCCCAGACAAGCCCAAGGAGGAGCTGGAGAAGGACTTCATCTCCCAGAGCAACGACATGCCCT
TTGATGAGCTGCTTGCGCTCTATGGCTACGAGGCGTCAGACCCCATTTCAGACCGGGAGAGTGAGGGTGGTGACGTGGCCCCGAACCTCC
CAGACATGACCCTGGACAAAGAACAAATAGCGAAGGATTTGCTTTCAGGGGAAGAAGAGGAAGAGACGCAATCATCTGCTGACGACCTCA
CCCCGTCCGTGACCTCCCACGAGGCCTCCGACCTCTTCCCTAACCGGAGTGGATCTCGTTTCCTGGCTGATGAAGACAGAGAGCCTGGCT
CTTCTGCCTCCTCCGACACCGAGGAGGACTCTCTTCCTGCCAACAAATGTAAGAAGGAGATCATGGTGGGACCTCAGTTCCAAGCTGACC
TCAGCAACCTGCACTTGAACCGGCACTGTGAGAAGAGCTGCATGGCTGAGAGGTTGAAGGAGGAGATTCTCAACAGAGAGAAAATGGTAG
ATATTTTGGCTGGTCCTGATGCCTACCGGGACCTTCCCCGGCTGCTGGCTGTTGCTGAGTCGGGCCAGCAAGCTGCCAACGTGCTGCTCT
CTCTGGACGAGACCTATGCTGATGTCATGCCAGTCCAGACAAGCGCCAGTGCCACGTCTGCCTTTGTGTCAATCATGCGAGGCTGTGACA
ACATGTGTAGCTACTGCATTGTTCCTTTCACCCGGGGCAGGGAGAGGAGTCGGCCTATTGCCTCCATTCTAGAGGAAGTGAAGAAGCTTT
CTGAGCAGGTGTTCCTCCCACCTCGGCCTCCCAAAGTGTTGGGATTACAGGGGCTGAAAGAAGTGACACTTCTTGGTCAGAATGTTAATA
GTTTTCGGGACAATTCGGAGGTCCAGTTCAACAGTGCAGTGCCTACCAATCTCAGTCGTGGCTTTACCACCAACTATAAAACCAAGCAAG
GAGGACTTCGTTTTGCTCATCTTCTGGATCAGGTCTCCAGAGTAGATCCTGAAATGAGGATCCGTTTTACCTCTCCCCACCCCAAGGATT
TTCCTGATGAGGTTCTGCAGCTGATTCATGAGAGAGATAACATCTGTAAACAGATCCACCTGCCAGCCCAGAGTGGAAGCAGCCGTGTGT
TGGAGGCCATGCGGAGGGGATATTCAAGAGAAGCTTATGTGGAGTTAGTTCACCATATTAGAGAATCTATTCCAGGTGTGAGCCTCAGCA
GCGATTTCATTGCTGGCTTTTGTGGTGAGACGGAGGAAGATCACGTCCAGACAGTCTCTTTGCTCCGGGAAGTTCAGTACAACATGGGCT
TCCTCTTTGCCTACAGCATGAGACAGAAGACACGGGCATATCATAGGCTGAAGGATGATGTCCCGGAAGAGGTAAAATTAAGGCGTTTGG
AGGAACTCATCACTATCTTCCGAGAAGAAGCAACAAAAGCCAATCAGACCTCTGTGGGCTGTACCCAGTTGGTGCTAGTGGAAGGGCTCA
GTAAACGCTCTGCCACTGACCTGTGTGGCAGGAATGATGGAAACCTTAAGGTGATCTTCCCTGATGCAGAGATGGAGGATGTCAATAACC
CTGGGCTCAGGGTCAGAGCCCAGCCTGGGGACTATGTGCTGGTGAAGATCACCTCAGCCAGTTCTCAGACACTTAGGGGACATGTTCTCT
GCAGGACCACTCTGAGGGACTCTTCTGCATATTGCTGACCTGAGAGGATGGCCTCAGAGCTGACTTGGGCAATCCTCCCCAACAGGAAGG
GGAGACATTGCCTGCCACTGAGGAAACAGGTCATGAAGGTGGAGATAAGCTGCAAGGGGCGAAGCAACTTTATGTCAGTGGAAAACGTGT

>53635_53635_3_MIER2-CDK5RAP1_MIER2_chr19_325634_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000357886_length(amino acids)=638AA_BP=219
MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGECEEASRCPDKPKEELEKDFISQSNDMPFDEL
LALYGYEASDPISDRESEGGDVAPNLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSAS
SDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKSCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDE
TYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQVFLPPRPPKVLGLQGLKEVTLLGQNVNSFRD
NSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAM
RRGYSREAYVELVHHIRESIPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELI
TIFREEATKANQTSVGCTQLVLVEGLSKRSATDLCGRNDGNLKVIFPDAEMEDVNNPGLRVRAQPGDYVLVKITSASSQTLRGHVLCRTT

--------------------------------------------------------------
>53635_53635_4_MIER2-CDK5RAP1_MIER2_chr19_325634_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000473997_length(transcript)=2090nt_BP=666nt
CACACACGGCCATGGCGGAGGCCTCCTCGCTGGGGAGGCAGAGTCCTCGCGTGGTCTCCTGCCTCGAGCACAGCCTGTGCCCAGGGGAGC
CGGGCTTGCAGACAACAGCAGTGGTGTCCATGGGCTCTGGAGACCATCAGTTCAACCTCGCAGAGATCCTGTCACAGAACTACAGTGTTA
GGGGGGAGTGCGAGGAGGCCTCGAGGTGCCCAGACAAGCCCAAGGAGGAGCTGGAGAAGGACTTCATCTCCCAGAGCAACGACATGCCCT
TTGATGAGCTGCTTGCGCTCTATGGCTACGAGGCGTCAGACCCCATTTCAGACCGGGAGAGTGAGGGTGGTGACGTGGCCCCGAACCTCC
CAGACATGACCCTGGACAAAGAACAAATAGCGAAGGATTTGCTTTCAGGGGAAGAAGAGGAAGAGACGCAATCATCTGCTGACGACCTCA
CCCCGTCCGTGACCTCCCACGAGGCCTCCGACCTCTTCCCTAACCGGAGTGGATCTCGTTTCCTGGCTGATGAAGACAGAGAGCCTGGCT
CTTCTGCCTCCTCCGACACCGAGGAGGACTCTCTTCCTGCCAACAAATGTAAGAAGGAGATCATGGTGGGACCTCAGTTCCAAGCTGACC
TCAGCAACCTGCACTTGAACCGGCACTGTGAGAAGAGCTGCATGGCTGAGAGGTTGAAGGAGGAGATTCTCAACAGAGAGAAAATGGTAG
ATATTTTGGCTGGTCCTGATGCCTACCGGGACCTTCCCCGGCTGCTGGCTGTTGCTGAGTCGGGCCAGCAAGCTGCCAACGTGCTGCTCT
CTCTGGACGAGACCTATGCTGATGTCATGCCAGTCCAGACAAGCGCCAGTGCCACGTCTGCCTTTGTGTCAATCATGCGAGGCTGTGACA
ACATGTGTAGCTACTGCATTGTTCCTTTCACCCGGGGCAGGGAGAGGAGTCGGCCTATTGCCTCCATTCTAGAGGAAGTGAAGAAGCTTT
CTGAGCAGGGGCTGAAAGAAGTGACACTTCTTGGTCAGAATGTTAATAGTTTTCGGGACAATTCGGAGGTCCAGTTCAACAGTGCAGTGC
CTACCAATCTCAGTCGTGGCTTTACCACCAACTATAAAACCAAGCAAGGAGGACTTCGTTTTGCTCATCTTCTGGATCAGGTCTCCAGAG
TAGATCCTGAAATGAGGATCCGTTTTACCTCTCCCCACCCCAAGGATTTTCCTGATGAGGTTCTGCAGCTGATTCATGAGAGAGATAACA
TCTGTAAACAGATCCACCTGCCAGCCCAGAGTGGAAGCAGCCGTGTGTTGGAGGCCATGCGGAGGGGATATTCAAGAGAAGCTTATGTGG
AGTTAGTTCACCATATTAGAGAATCTATTCCAGGTGTGAGCCTCAGCAGCGATTTCATTGCTGGCTTTTGTGGTGAGACGGAGGAAGATC
ACGTCCAGACAGTCTCTTTGCTCCGGGAAGTTCAGTACAACATGGGCTTCCTCTTTGCCTACAGCATGAGACAGAAGACACGGGCATATC
ATAGGCTGAAGGATGATGTCCCGGAAGAGGTAAAATTAAGGCGTTTGGAGGAACTCATCACTATCTTCCGAGAAGAAGCAACAAAAGCCA
ATCAGACCTCTGTGGGCTGTACCCAGTTGGTGCTAGTGGAAGGGCTCAGTAAACGCTCTGCCACTGACCTGTGTGGCAGGAATGATGGAA
ACCTTAAGGTGATCTTCCCTGATGCAGAGATGGAGGATGTCAATAACCCTGGGCTCAGGGTCAGAGCCCAGCCTGGGGACTATGTGCTGG
TGAAGATCACCTCAGCCAGTTCTCAGACACTTAGGGGACATGTTCTCTGCAGGACCACTCTGAGGGACTCTTCTGCATATTGCTGACCTG
AGAGGATGGCCTCAGAGCTGACTTGGGCAATCCTCCCCAACAGGAAGGGGAGACATTGCCTGCCACTGAGGAAACAGGTCATGAAGGTGG
AGATAAGCTGCAAGGGGCGAAGCAACTTTATGTCAGTGGAAAACGTGTCTCTTTAAAGCTGCTATGTGAACAGCTTTTACAGTCATTAAA

>53635_53635_4_MIER2-CDK5RAP1_MIER2_chr19_325634_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000473997_length(amino acids)=624AA_BP=219
MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGECEEASRCPDKPKEELEKDFISQSNDMPFDEL
LALYGYEASDPISDRESEGGDVAPNLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSAS
SDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKSCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDE
TYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNL
SRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAMRRGYSREAYVELVH
HIRESIPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITIFREEATKANQTS

--------------------------------------------------------------
>53635_53635_5_MIER2-CDK5RAP1_MIER2_chr19_325634_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000544843_length(transcript)=1801nt_BP=666nt
CACACACGGCCATGGCGGAGGCCTCCTCGCTGGGGAGGCAGAGTCCTCGCGTGGTCTCCTGCCTCGAGCACAGCCTGTGCCCAGGGGAGC
CGGGCTTGCAGACAACAGCAGTGGTGTCCATGGGCTCTGGAGACCATCAGTTCAACCTCGCAGAGATCCTGTCACAGAACTACAGTGTTA
GGGGGGAGTGCGAGGAGGCCTCGAGGTGCCCAGACAAGCCCAAGGAGGAGCTGGAGAAGGACTTCATCTCCCAGAGCAACGACATGCCCT
TTGATGAGCTGCTTGCGCTCTATGGCTACGAGGCGTCAGACCCCATTTCAGACCGGGAGAGTGAGGGTGGTGACGTGGCCCCGAACCTCC
CAGACATGACCCTGGACAAAGAACAAATAGCGAAGGATTTGCTTTCAGGGGAAGAAGAGGAAGAGACGCAATCATCTGCTGACGACCTCA
CCCCGTCCGTGACCTCCCACGAGGCCTCCGACCTCTTCCCTAACCGGAGTGGATCTCGTTTCCTGGCTGATGAAGACAGAGAGCCTGGCT
CTTCTGCCTCCTCCGACACCGAGGAGGACTCTCTTCCTGCCAACAAATGTAAGAAGGAGATCATGGTGGGACCTCAGTTCCAAGCTGACC
TCAGCAACCTGCACTTGAACCGGCACTGTGAGAAGAGCTGCATGGCTGAGAGGTTGAAGGAGGAGATTCTCAACAGAGAGAAAATGGTAG
ATATTTTGGCTGGTCCTGATGCCTACCGGGACCTTCCCCGGCTGCTGGCTGTTGCTGAGTCGGGCCAGCAAGCTGCCAACGTGCTGCTCT
CTCTGGACGAGACCTATGCTGATGTCATGCCAGTCCAGACAAGCGCCAGTGCCACGTCTGCCTTTGTGTCAATCATGCGAGGCTGTGACA
ACATGTGTAGCTACTGCATTGTTCCTTTCACCCGGGGCAGGGAGAGGAGTCGGCCTATTGCCTCCATTCTAGAGGAAGTGAAGAAGCTTT
CTGAGCAGGGGCTGAAAGAAGTGACACTTCTTGGTCAGAATGTTAATAGTTTTCGGGACAATTCGGAGGTCCAGTTCAACAGTGCAGTGC
CTACCAATCTCAGTCGTGGCTTTACCACCAACTATAAAACCAAGCAAGGAGGACTTCGTTTTGCTCATCTTCTGGATCAGGTCTCCAGAG
TAGATCCTGAAATGAGGATCCGTTTTACCTCTCCCCACCCCAAGGATTTTCCTGATGAGGTTCTGCAGCTGATTCATGAGAGAGATAACA
TCTGTAAACAGATCCACCTGCCAGCCCAGAGTGGAAGCAGCCGTGTGTTGGAGGCCATGCGGAGGGGATATTCAAGAGAAGCTTATGTGG
AGTTAGTTCACCATATTAGAGAATCTATTCCAGAAGACACGGGCATATCATAGGCTGAAGGATGATGTCCCGGAAGAGGTAAAATTAAGG
CGTTTGGAGGAACTCATCACTATCTTCCGAGAAGAAGCAACAAAAGCCAATCAGACCTCTGTGGGCTGTACCCAGTTGGTGCTAGTGGAA
GGGCTCAGTAAACGCTCTGCCACTGACCTGTGTGGCAGGAATGATGGAAACCTTAAGGTGATCTTCCCTGATGCAGAGATGGAGGATGTC
AATAACCCTGGGCTCAGGGTCAGAGCCCAGCCTGGGGACTATGTGCTGGTGAAGGTGAGGAGTCCTTTTGGGCTTTTGGCTTGCACTGTG
AAATGAGTGTTGGTTTGGATATTTGTGGTAATAAAGTTTTTTCCTAGAGACACATTTTAGTAAAATAAAAATCCCCTCTCAACCAGTACA

>53635_53635_5_MIER2-CDK5RAP1_MIER2_chr19_325634_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000544843_length(amino acids)=463AA_BP=219
MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGECEEASRCPDKPKEELEKDFISQSNDMPFDEL
LALYGYEASDPISDRESEGGDVAPNLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSAS
SDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKSCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDE
TYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNL
SRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAMRRGYSREAYVELVH

--------------------------------------------------------------
>53635_53635_6_MIER2-CDK5RAP1_MIER2_chr19_325635_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000339269_length(transcript)=1859nt_BP=666nt
CACACACGGCCATGGCGGAGGCCTCCTCGCTGGGGAGGCAGAGTCCTCGCGTGGTCTCCTGCCTCGAGCACAGCCTGTGCCCAGGGGAGC
CGGGCTTGCAGACAACAGCAGTGGTGTCCATGGGCTCTGGAGACCATCAGTTCAACCTCGCAGAGATCCTGTCACAGAACTACAGTGTTA
GGGGGGAGTGCGAGGAGGCCTCGAGGTGCCCAGACAAGCCCAAGGAGGAGCTGGAGAAGGACTTCATCTCCCAGAGCAACGACATGCCCT
TTGATGAGCTGCTTGCGCTCTATGGCTACGAGGCGTCAGACCCCATTTCAGACCGGGAGAGTGAGGGTGGTGACGTGGCCCCGAACCTCC
CAGACATGACCCTGGACAAAGAACAAATAGCGAAGGATTTGCTTTCAGGGGAAGAAGAGGAAGAGACGCAATCATCTGCTGACGACCTCA
CCCCGTCCGTGACCTCCCACGAGGCCTCCGACCTCTTCCCTAACCGGAGTGGATCTCGTTTCCTGGCTGATGAAGACAGAGAGCCTGGCT
CTTCTGCCTCCTCCGACACCGAGGAGGACTCTCTTCCTGCCAACAAATGTAAGAAGGAGATCATGGTGGGACCTCAGTTCCAAGCTGACC
TCAGCAACCTGCACTTGAACCGGCACTGTGAGAAGAGCTGCATGGCTGAGAGGTTGAAGGAGGAGATTCTCAACAGAGAGAAAATGGTAG
ATATTTTGGCTGGTCCTGATGCCTACCGGGACCTTCCCCGGCTGCTGGCTGTTGCTGAGTCGGGCCAGCAAGCTGCCAACGTGCTGCTCT
CTCTGGACGAGACCTATGCTGATGTCATGCCAGTCCAGACAAGCGCCAGTGCCACGTCTGCCTTTGTGTCAATCATGCGAGGCTGTGACA
ACATGTGTAGCTACTGCATTGTTCCTTTCACCCGGGGCAGGGAGAGGAGTCGGCCTATTGCCTCCATTCTAGAGGAAGTGAAGAAGCTTT
CTGAGCAGGTTCTGCAGCTGATTCATGAGAGAGATAACATCTGTAAACAGATCCACCTGCCAGCCCAGAGTGGAAGCAGCCGTGTGTTGG
AGGCCATGCGGAGGGGATATTCAAGAGAAGCTTATGTGGAGTTAGTTCACCATATTAGAGAATCTATTCCAGGTGTGAGCCTCAGCAGCG
ATTTCATTGCTGGCTTTTGTGGTGAGACGGAGGAAGATCACGTCCAGACAGTCTCTTTGCTCCGGGAAGTTCAGTACAACATGGGCTTCC
TCTTTGCCTACAGCATGAGACAGAAGACACGGGCATATCATAGGCTGAAGGATGATGTCCCGGAAGAGGTAAAATTAAGGCGTTTGGAGG
AACTCATCACTATCTTCCGAGAAGAAGCAACAAAAGCCAATCAGACCTCTGTGGGCTGTACCCAGTTGGTGCTAGTGGAAGGGCTCAGTA
AACGCTCTGCCACTGACCTGTGTGGCAGGAATGATGGAAACCTTAAGGTGATCTTCCCTGATGCAGAGATGGAGGATGTCAATAACCCTG
GGCTCAGGGTCAGAGCCCAGCCTGGGGACTATGTGCTGGTGAAGATCACCTCAGCCAGTTCTCAGACACTTAGGGGACATGTTCTCTGCA
GGACCACTCTGAGGGACTCTTCTGCATATTGCTGACCTGAGAGGATGGCCTCAGAGCTGACTTGGGCAATCCTCCCCAACAGGAAGGGGA
GACATTGCCTGCCACTGAGGAAACAGGTCATGAAGGTGGAGATAAGCTGCAAGGGGCGAAGCAACTTTATGTCAGTGGAAAACGTGTCTC

>53635_53635_6_MIER2-CDK5RAP1_MIER2_chr19_325635_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000339269_length(amino acids)=547AA_BP=219
MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGECEEASRCPDKPKEELEKDFISQSNDMPFDEL
LALYGYEASDPISDRESEGGDVAPNLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSAS
SDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKSCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDE
TYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQVLQLIHERDNICKQIHLPAQSGSSRVLEAMR
RGYSREAYVELVHHIRESIPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELIT
IFREEATKANQTSVGCTQLVLVEGLSKRSATDLCGRNDGNLKVIFPDAEMEDVNNPGLRVRAQPGDYVLVKITSASSQTLRGHVLCRTTL

--------------------------------------------------------------
>53635_53635_7_MIER2-CDK5RAP1_MIER2_chr19_325635_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000346416_length(transcript)=2090nt_BP=666nt
CACACACGGCCATGGCGGAGGCCTCCTCGCTGGGGAGGCAGAGTCCTCGCGTGGTCTCCTGCCTCGAGCACAGCCTGTGCCCAGGGGAGC
CGGGCTTGCAGACAACAGCAGTGGTGTCCATGGGCTCTGGAGACCATCAGTTCAACCTCGCAGAGATCCTGTCACAGAACTACAGTGTTA
GGGGGGAGTGCGAGGAGGCCTCGAGGTGCCCAGACAAGCCCAAGGAGGAGCTGGAGAAGGACTTCATCTCCCAGAGCAACGACATGCCCT
TTGATGAGCTGCTTGCGCTCTATGGCTACGAGGCGTCAGACCCCATTTCAGACCGGGAGAGTGAGGGTGGTGACGTGGCCCCGAACCTCC
CAGACATGACCCTGGACAAAGAACAAATAGCGAAGGATTTGCTTTCAGGGGAAGAAGAGGAAGAGACGCAATCATCTGCTGACGACCTCA
CCCCGTCCGTGACCTCCCACGAGGCCTCCGACCTCTTCCCTAACCGGAGTGGATCTCGTTTCCTGGCTGATGAAGACAGAGAGCCTGGCT
CTTCTGCCTCCTCCGACACCGAGGAGGACTCTCTTCCTGCCAACAAATGTAAGAAGGAGATCATGGTGGGACCTCAGTTCCAAGCTGACC
TCAGCAACCTGCACTTGAACCGGCACTGTGAGAAGAGCTGCATGGCTGAGAGGTTGAAGGAGGAGATTCTCAACAGAGAGAAAATGGTAG
ATATTTTGGCTGGTCCTGATGCCTACCGGGACCTTCCCCGGCTGCTGGCTGTTGCTGAGTCGGGCCAGCAAGCTGCCAACGTGCTGCTCT
CTCTGGACGAGACCTATGCTGATGTCATGCCAGTCCAGACAAGCGCCAGTGCCACGTCTGCCTTTGTGTCAATCATGCGAGGCTGTGACA
ACATGTGTAGCTACTGCATTGTTCCTTTCACCCGGGGCAGGGAGAGGAGTCGGCCTATTGCCTCCATTCTAGAGGAAGTGAAGAAGCTTT
CTGAGCAGGGGCTGAAAGAAGTGACACTTCTTGGTCAGAATGTTAATAGTTTTCGGGACAATTCGGAGGTCCAGTTCAACAGTGCAGTGC
CTACCAATCTCAGTCGTGGCTTTACCACCAACTATAAAACCAAGCAAGGAGGACTTCGTTTTGCTCATCTTCTGGATCAGGTCTCCAGAG
TAGATCCTGAAATGAGGATCCGTTTTACCTCTCCCCACCCCAAGGATTTTCCTGATGAGGTTCTGCAGCTGATTCATGAGAGAGATAACA
TCTGTAAACAGATCCACCTGCCAGCCCAGAGTGGAAGCAGCCGTGTGTTGGAGGCCATGCGGAGGGGATATTCAAGAGAAGCTTATGTGG
AGTTAGTTCACCATATTAGAGAATCTATTCCAGGTGTGAGCCTCAGCAGCGATTTCATTGCTGGCTTTTGTGGTGAGACGGAGGAAGATC
ACGTCCAGACAGTCTCTTTGCTCCGGGAAGTTCAGTACAACATGGGCTTCCTCTTTGCCTACAGCATGAGACAGAAGACACGGGCATATC
ATAGGCTGAAGGATGATGTCCCGGAAGAGGTAAAATTAAGGCGTTTGGAGGAACTCATCACTATCTTCCGAGAAGAAGCAACAAAAGCCA
ATCAGACCTCTGTGGGCTGTACCCAGTTGGTGCTAGTGGAAGGGCTCAGTAAACGCTCTGCCACTGACCTGTGTGGCAGGAATGATGGAA
ACCTTAAGGTGATCTTCCCTGATGCAGAGATGGAGGATGTCAATAACCCTGGGCTCAGGGTCAGAGCCCAGCCTGGGGACTATGTGCTGG
TGAAGATCACCTCAGCCAGTTCTCAGACACTTAGGGGACATGTTCTCTGCAGGACCACTCTGAGGGACTCTTCTGCATATTGCTGACCTG
AGAGGATGGCCTCAGAGCTGACTTGGGCAATCCTCCCCAACAGGAAGGGGAGACATTGCCTGCCACTGAGGAAACAGGTCATGAAGGTGG
AGATAAGCTGCAAGGGGCGAAGCAACTTTATGTCAGTGGAAAACGTGTCTCTTTAAAGCTGCTATGTGAACAGCTTTTACAGTCATTAAA

>53635_53635_7_MIER2-CDK5RAP1_MIER2_chr19_325635_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000346416_length(amino acids)=624AA_BP=219
MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGECEEASRCPDKPKEELEKDFISQSNDMPFDEL
LALYGYEASDPISDRESEGGDVAPNLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSAS
SDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKSCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDE
TYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNL
SRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAMRRGYSREAYVELVH
HIRESIPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITIFREEATKANQTS

--------------------------------------------------------------
>53635_53635_8_MIER2-CDK5RAP1_MIER2_chr19_325635_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000357886_length(transcript)=2132nt_BP=666nt
CACACACGGCCATGGCGGAGGCCTCCTCGCTGGGGAGGCAGAGTCCTCGCGTGGTCTCCTGCCTCGAGCACAGCCTGTGCCCAGGGGAGC
CGGGCTTGCAGACAACAGCAGTGGTGTCCATGGGCTCTGGAGACCATCAGTTCAACCTCGCAGAGATCCTGTCACAGAACTACAGTGTTA
GGGGGGAGTGCGAGGAGGCCTCGAGGTGCCCAGACAAGCCCAAGGAGGAGCTGGAGAAGGACTTCATCTCCCAGAGCAACGACATGCCCT
TTGATGAGCTGCTTGCGCTCTATGGCTACGAGGCGTCAGACCCCATTTCAGACCGGGAGAGTGAGGGTGGTGACGTGGCCCCGAACCTCC
CAGACATGACCCTGGACAAAGAACAAATAGCGAAGGATTTGCTTTCAGGGGAAGAAGAGGAAGAGACGCAATCATCTGCTGACGACCTCA
CCCCGTCCGTGACCTCCCACGAGGCCTCCGACCTCTTCCCTAACCGGAGTGGATCTCGTTTCCTGGCTGATGAAGACAGAGAGCCTGGCT
CTTCTGCCTCCTCCGACACCGAGGAGGACTCTCTTCCTGCCAACAAATGTAAGAAGGAGATCATGGTGGGACCTCAGTTCCAAGCTGACC
TCAGCAACCTGCACTTGAACCGGCACTGTGAGAAGAGCTGCATGGCTGAGAGGTTGAAGGAGGAGATTCTCAACAGAGAGAAAATGGTAG
ATATTTTGGCTGGTCCTGATGCCTACCGGGACCTTCCCCGGCTGCTGGCTGTTGCTGAGTCGGGCCAGCAAGCTGCCAACGTGCTGCTCT
CTCTGGACGAGACCTATGCTGATGTCATGCCAGTCCAGACAAGCGCCAGTGCCACGTCTGCCTTTGTGTCAATCATGCGAGGCTGTGACA
ACATGTGTAGCTACTGCATTGTTCCTTTCACCCGGGGCAGGGAGAGGAGTCGGCCTATTGCCTCCATTCTAGAGGAAGTGAAGAAGCTTT
CTGAGCAGGTGTTCCTCCCACCTCGGCCTCCCAAAGTGTTGGGATTACAGGGGCTGAAAGAAGTGACACTTCTTGGTCAGAATGTTAATA
GTTTTCGGGACAATTCGGAGGTCCAGTTCAACAGTGCAGTGCCTACCAATCTCAGTCGTGGCTTTACCACCAACTATAAAACCAAGCAAG
GAGGACTTCGTTTTGCTCATCTTCTGGATCAGGTCTCCAGAGTAGATCCTGAAATGAGGATCCGTTTTACCTCTCCCCACCCCAAGGATT
TTCCTGATGAGGTTCTGCAGCTGATTCATGAGAGAGATAACATCTGTAAACAGATCCACCTGCCAGCCCAGAGTGGAAGCAGCCGTGTGT
TGGAGGCCATGCGGAGGGGATATTCAAGAGAAGCTTATGTGGAGTTAGTTCACCATATTAGAGAATCTATTCCAGGTGTGAGCCTCAGCA
GCGATTTCATTGCTGGCTTTTGTGGTGAGACGGAGGAAGATCACGTCCAGACAGTCTCTTTGCTCCGGGAAGTTCAGTACAACATGGGCT
TCCTCTTTGCCTACAGCATGAGACAGAAGACACGGGCATATCATAGGCTGAAGGATGATGTCCCGGAAGAGGTAAAATTAAGGCGTTTGG
AGGAACTCATCACTATCTTCCGAGAAGAAGCAACAAAAGCCAATCAGACCTCTGTGGGCTGTACCCAGTTGGTGCTAGTGGAAGGGCTCA
GTAAACGCTCTGCCACTGACCTGTGTGGCAGGAATGATGGAAACCTTAAGGTGATCTTCCCTGATGCAGAGATGGAGGATGTCAATAACC
CTGGGCTCAGGGTCAGAGCCCAGCCTGGGGACTATGTGCTGGTGAAGATCACCTCAGCCAGTTCTCAGACACTTAGGGGACATGTTCTCT
GCAGGACCACTCTGAGGGACTCTTCTGCATATTGCTGACCTGAGAGGATGGCCTCAGAGCTGACTTGGGCAATCCTCCCCAACAGGAAGG
GGAGACATTGCCTGCCACTGAGGAAACAGGTCATGAAGGTGGAGATAAGCTGCAAGGGGCGAAGCAACTTTATGTCAGTGGAAAACGTGT

>53635_53635_8_MIER2-CDK5RAP1_MIER2_chr19_325635_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000357886_length(amino acids)=638AA_BP=219
MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGECEEASRCPDKPKEELEKDFISQSNDMPFDEL
LALYGYEASDPISDRESEGGDVAPNLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSAS
SDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKSCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDE
TYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQVFLPPRPPKVLGLQGLKEVTLLGQNVNSFRD
NSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAM
RRGYSREAYVELVHHIRESIPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELI
TIFREEATKANQTSVGCTQLVLVEGLSKRSATDLCGRNDGNLKVIFPDAEMEDVNNPGLRVRAQPGDYVLVKITSASSQTLRGHVLCRTT

--------------------------------------------------------------
>53635_53635_9_MIER2-CDK5RAP1_MIER2_chr19_325635_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000473997_length(transcript)=2090nt_BP=666nt
CACACACGGCCATGGCGGAGGCCTCCTCGCTGGGGAGGCAGAGTCCTCGCGTGGTCTCCTGCCTCGAGCACAGCCTGTGCCCAGGGGAGC
CGGGCTTGCAGACAACAGCAGTGGTGTCCATGGGCTCTGGAGACCATCAGTTCAACCTCGCAGAGATCCTGTCACAGAACTACAGTGTTA
GGGGGGAGTGCGAGGAGGCCTCGAGGTGCCCAGACAAGCCCAAGGAGGAGCTGGAGAAGGACTTCATCTCCCAGAGCAACGACATGCCCT
TTGATGAGCTGCTTGCGCTCTATGGCTACGAGGCGTCAGACCCCATTTCAGACCGGGAGAGTGAGGGTGGTGACGTGGCCCCGAACCTCC
CAGACATGACCCTGGACAAAGAACAAATAGCGAAGGATTTGCTTTCAGGGGAAGAAGAGGAAGAGACGCAATCATCTGCTGACGACCTCA
CCCCGTCCGTGACCTCCCACGAGGCCTCCGACCTCTTCCCTAACCGGAGTGGATCTCGTTTCCTGGCTGATGAAGACAGAGAGCCTGGCT
CTTCTGCCTCCTCCGACACCGAGGAGGACTCTCTTCCTGCCAACAAATGTAAGAAGGAGATCATGGTGGGACCTCAGTTCCAAGCTGACC
TCAGCAACCTGCACTTGAACCGGCACTGTGAGAAGAGCTGCATGGCTGAGAGGTTGAAGGAGGAGATTCTCAACAGAGAGAAAATGGTAG
ATATTTTGGCTGGTCCTGATGCCTACCGGGACCTTCCCCGGCTGCTGGCTGTTGCTGAGTCGGGCCAGCAAGCTGCCAACGTGCTGCTCT
CTCTGGACGAGACCTATGCTGATGTCATGCCAGTCCAGACAAGCGCCAGTGCCACGTCTGCCTTTGTGTCAATCATGCGAGGCTGTGACA
ACATGTGTAGCTACTGCATTGTTCCTTTCACCCGGGGCAGGGAGAGGAGTCGGCCTATTGCCTCCATTCTAGAGGAAGTGAAGAAGCTTT
CTGAGCAGGGGCTGAAAGAAGTGACACTTCTTGGTCAGAATGTTAATAGTTTTCGGGACAATTCGGAGGTCCAGTTCAACAGTGCAGTGC
CTACCAATCTCAGTCGTGGCTTTACCACCAACTATAAAACCAAGCAAGGAGGACTTCGTTTTGCTCATCTTCTGGATCAGGTCTCCAGAG
TAGATCCTGAAATGAGGATCCGTTTTACCTCTCCCCACCCCAAGGATTTTCCTGATGAGGTTCTGCAGCTGATTCATGAGAGAGATAACA
TCTGTAAACAGATCCACCTGCCAGCCCAGAGTGGAAGCAGCCGTGTGTTGGAGGCCATGCGGAGGGGATATTCAAGAGAAGCTTATGTGG
AGTTAGTTCACCATATTAGAGAATCTATTCCAGGTGTGAGCCTCAGCAGCGATTTCATTGCTGGCTTTTGTGGTGAGACGGAGGAAGATC
ACGTCCAGACAGTCTCTTTGCTCCGGGAAGTTCAGTACAACATGGGCTTCCTCTTTGCCTACAGCATGAGACAGAAGACACGGGCATATC
ATAGGCTGAAGGATGATGTCCCGGAAGAGGTAAAATTAAGGCGTTTGGAGGAACTCATCACTATCTTCCGAGAAGAAGCAACAAAAGCCA
ATCAGACCTCTGTGGGCTGTACCCAGTTGGTGCTAGTGGAAGGGCTCAGTAAACGCTCTGCCACTGACCTGTGTGGCAGGAATGATGGAA
ACCTTAAGGTGATCTTCCCTGATGCAGAGATGGAGGATGTCAATAACCCTGGGCTCAGGGTCAGAGCCCAGCCTGGGGACTATGTGCTGG
TGAAGATCACCTCAGCCAGTTCTCAGACACTTAGGGGACATGTTCTCTGCAGGACCACTCTGAGGGACTCTTCTGCATATTGCTGACCTG
AGAGGATGGCCTCAGAGCTGACTTGGGCAATCCTCCCCAACAGGAAGGGGAGACATTGCCTGCCACTGAGGAAACAGGTCATGAAGGTGG
AGATAAGCTGCAAGGGGCGAAGCAACTTTATGTCAGTGGAAAACGTGTCTCTTTAAAGCTGCTATGTGAACAGCTTTTACAGTCATTAAA

>53635_53635_9_MIER2-CDK5RAP1_MIER2_chr19_325635_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000473997_length(amino acids)=624AA_BP=219
MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGECEEASRCPDKPKEELEKDFISQSNDMPFDEL
LALYGYEASDPISDRESEGGDVAPNLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSAS
SDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKSCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDE
TYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNL
SRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAMRRGYSREAYVELVH
HIRESIPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITIFREEATKANQTS

--------------------------------------------------------------
>53635_53635_10_MIER2-CDK5RAP1_MIER2_chr19_325635_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000544843_length(transcript)=1801nt_BP=666nt
CACACACGGCCATGGCGGAGGCCTCCTCGCTGGGGAGGCAGAGTCCTCGCGTGGTCTCCTGCCTCGAGCACAGCCTGTGCCCAGGGGAGC
CGGGCTTGCAGACAACAGCAGTGGTGTCCATGGGCTCTGGAGACCATCAGTTCAACCTCGCAGAGATCCTGTCACAGAACTACAGTGTTA
GGGGGGAGTGCGAGGAGGCCTCGAGGTGCCCAGACAAGCCCAAGGAGGAGCTGGAGAAGGACTTCATCTCCCAGAGCAACGACATGCCCT
TTGATGAGCTGCTTGCGCTCTATGGCTACGAGGCGTCAGACCCCATTTCAGACCGGGAGAGTGAGGGTGGTGACGTGGCCCCGAACCTCC
CAGACATGACCCTGGACAAAGAACAAATAGCGAAGGATTTGCTTTCAGGGGAAGAAGAGGAAGAGACGCAATCATCTGCTGACGACCTCA
CCCCGTCCGTGACCTCCCACGAGGCCTCCGACCTCTTCCCTAACCGGAGTGGATCTCGTTTCCTGGCTGATGAAGACAGAGAGCCTGGCT
CTTCTGCCTCCTCCGACACCGAGGAGGACTCTCTTCCTGCCAACAAATGTAAGAAGGAGATCATGGTGGGACCTCAGTTCCAAGCTGACC
TCAGCAACCTGCACTTGAACCGGCACTGTGAGAAGAGCTGCATGGCTGAGAGGTTGAAGGAGGAGATTCTCAACAGAGAGAAAATGGTAG
ATATTTTGGCTGGTCCTGATGCCTACCGGGACCTTCCCCGGCTGCTGGCTGTTGCTGAGTCGGGCCAGCAAGCTGCCAACGTGCTGCTCT
CTCTGGACGAGACCTATGCTGATGTCATGCCAGTCCAGACAAGCGCCAGTGCCACGTCTGCCTTTGTGTCAATCATGCGAGGCTGTGACA
ACATGTGTAGCTACTGCATTGTTCCTTTCACCCGGGGCAGGGAGAGGAGTCGGCCTATTGCCTCCATTCTAGAGGAAGTGAAGAAGCTTT
CTGAGCAGGGGCTGAAAGAAGTGACACTTCTTGGTCAGAATGTTAATAGTTTTCGGGACAATTCGGAGGTCCAGTTCAACAGTGCAGTGC
CTACCAATCTCAGTCGTGGCTTTACCACCAACTATAAAACCAAGCAAGGAGGACTTCGTTTTGCTCATCTTCTGGATCAGGTCTCCAGAG
TAGATCCTGAAATGAGGATCCGTTTTACCTCTCCCCACCCCAAGGATTTTCCTGATGAGGTTCTGCAGCTGATTCATGAGAGAGATAACA
TCTGTAAACAGATCCACCTGCCAGCCCAGAGTGGAAGCAGCCGTGTGTTGGAGGCCATGCGGAGGGGATATTCAAGAGAAGCTTATGTGG
AGTTAGTTCACCATATTAGAGAATCTATTCCAGAAGACACGGGCATATCATAGGCTGAAGGATGATGTCCCGGAAGAGGTAAAATTAAGG
CGTTTGGAGGAACTCATCACTATCTTCCGAGAAGAAGCAACAAAAGCCAATCAGACCTCTGTGGGCTGTACCCAGTTGGTGCTAGTGGAA
GGGCTCAGTAAACGCTCTGCCACTGACCTGTGTGGCAGGAATGATGGAAACCTTAAGGTGATCTTCCCTGATGCAGAGATGGAGGATGTC
AATAACCCTGGGCTCAGGGTCAGAGCCCAGCCTGGGGACTATGTGCTGGTGAAGGTGAGGAGTCCTTTTGGGCTTTTGGCTTGCACTGTG
AAATGAGTGTTGGTTTGGATATTTGTGGTAATAAAGTTTTTTCCTAGAGACACATTTTAGTAAAATAAAAATCCCCTCTCAACCAGTACA

>53635_53635_10_MIER2-CDK5RAP1_MIER2_chr19_325635_ENST00000264819_CDK5RAP1_chr20_31975339_ENST00000544843_length(amino acids)=463AA_BP=219
MAEASSLGRQSPRVVSCLEHSLCPGEPGLQTTAVVSMGSGDHQFNLAEILSQNYSVRGECEEASRCPDKPKEELEKDFISQSNDMPFDEL
LALYGYEASDPISDRESEGGDVAPNLPDMTLDKEQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDREPGSSAS
SDTEEDSLPANKCKKEIMVGPQFQADLSNLHLNRHCEKSCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDE
TYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNL
SRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAMRRGYSREAYVELVH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MIER2-CDK5RAP1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MIER2-CDK5RAP1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MIER2-CDK5RAP1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source