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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MIOS-ADAP1 (FusionGDB2 ID:53739)

Fusion Gene Summary for MIOS-ADAP1

Fusion gene summary

Fusion gene information	Fusion gene name: MIOS-ADAP1
	Fusion gene ID: 53739
		Hgene	Tgene
	Gene symbol	MIOS	ADAP1
	Gene ID	54468	11033
	Gene name	meiosis regulator for oocyte development	ArfGAP with dual PH domains 1
	Synonyms	MIO\|Sea4\|Yulink	CENTA1\|GCS1L\|p42IP4
	Cytomap	7p21.3	7p22.3
	Type of gene	protein-coding	protein-coding
	Description	GATOR complex protein MIOSH_DJ1159O04.1WD repeat-containing protein mioWUGSC:H_DJ1159O04.1missing oocyte, meiosis regulator, homolog	arf-GAP with dual PH domain-containing protein 1centaurin-alphacentaurin-alpha-1cnt-a1putative MAPK-activating protein PM25
	Modification date	20200313	20200313
	UniProtAcc	.	O75689
	Ensembl transtripts involved in fusion gene	ENST00000340080, ENST00000405785, ENST00000461907,	ENST00000463358, ENST00000449296, ENST00000539900, ENST00000265846,
Fusion gene scores	* DoF score	2 X 2 X 2=8	6 X 4 X 4=96
	# samples	2	6
	** MAII score	log2(2/8*10)=1.32192809488736	log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MIOS [Title/Abstract] AND ADAP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MIOS(7613827)-ADAP1(975141), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MIOS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ADAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A0B7-01A	MIOS	chr7	7613827	-	ADAP1	chr7	975141	-

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Fusion Gene ORF analysis for MIOS-ADAP1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000340080	ENST00000463358	MIOS	chr7	7613827	-	ADAP1	chr7	975141	-
5CDS-5UTR	ENST00000405785	ENST00000463358	MIOS	chr7	7613827	-	ADAP1	chr7	975141	-
5CDS-intron	ENST00000340080	ENST00000449296	MIOS	chr7	7613827	-	ADAP1	chr7	975141	-
5CDS-intron	ENST00000340080	ENST00000539900	MIOS	chr7	7613827	-	ADAP1	chr7	975141	-
5CDS-intron	ENST00000405785	ENST00000449296	MIOS	chr7	7613827	-	ADAP1	chr7	975141	-
5CDS-intron	ENST00000405785	ENST00000539900	MIOS	chr7	7613827	-	ADAP1	chr7	975141	-
In-frame	ENST00000340080	ENST00000265846	MIOS	chr7	7613827	-	ADAP1	chr7	975141	-
In-frame	ENST00000405785	ENST00000265846	MIOS	chr7	7613827	-	ADAP1	chr7	975141	-
intron-3CDS	ENST00000461907	ENST00000265846	MIOS	chr7	7613827	-	ADAP1	chr7	975141	-
intron-5UTR	ENST00000461907	ENST00000463358	MIOS	chr7	7613827	-	ADAP1	chr7	975141	-
intron-intron	ENST00000461907	ENST00000449296	MIOS	chr7	7613827	-	ADAP1	chr7	975141	-
intron-intron	ENST00000461907	ENST00000539900	MIOS	chr7	7613827	-	ADAP1	chr7	975141	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000340080	MIOS	chr7	7613827	-	ENST00000265846	ADAP1	chr7	975141	-	3875	1814	403	2856	817
ENST00000405785	MIOS	chr7	7613827	-	ENST00000265846	ADAP1	chr7	975141	-	3790	1729	318	2771	817

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000340080	ENST00000265846	MIOS	chr7	7613827	-	ADAP1	chr7	975141	-	0.002515626	0.9974843
ENST00000405785	ENST00000265846	MIOS	chr7	7613827	-	ADAP1	chr7	975141	-	0.002541307	0.99745876

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Fusion Genomic Features for MIOS-ADAP1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MIOS-ADAP1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:7613827/chr7:975141)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ADAP1 O75689
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). {ECO:0000269\|PubMed:10448098, ECO:0000303\|PubMed:10333475, ECO:0000305}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MIOS

chr7:7613827

chr7:975141

ENST00000340080

111_155

464

876.0

Repeat

Note=WD 2

Hgene

MIOS

chr7:7613827

chr7:975141

ENST00000340080

182_221

464

876.0

Repeat

Note=WD 3

Hgene

MIOS

chr7:7613827

chr7:975141

ENST00000340080

223_261

464

876.0

Repeat

Note=WD 4

Hgene

MIOS

chr7:7613827

chr7:975141

ENST00000340080

265_306

464

876.0

Repeat

Note=WD 5

Hgene

MIOS

chr7:7613827

chr7:975141

ENST00000340080

395_437

464

876.0

Repeat

Note=WD 6

Hgene

MIOS

chr7:7613827

chr7:975141

ENST00000340080

58_100

464

876.0

Repeat

Note=WD 1

Hgene

MIOS

chr7:7613827

chr7:975141

ENST00000405785

111_155

464

876.0

Repeat

Note=WD 2

Hgene

MIOS

chr7:7613827

chr7:975141

ENST00000405785

182_221

464

876.0

Repeat

Note=WD 3

Hgene

MIOS

chr7:7613827

chr7:975141

ENST00000405785

223_261

464

876.0

Repeat

Note=WD 4

Hgene

MIOS

chr7:7613827

chr7:975141

ENST00000405785

265_306

464

876.0

Repeat

Note=WD 5

Hgene

MIOS

chr7:7613827

chr7:975141

ENST00000405785

395_437

464

876.0

Repeat

Note=WD 6

Hgene

MIOS

chr7:7613827

chr7:975141

ENST00000405785

58_100

464

876.0

Repeat

Note=WD 1

Tgene

ADAP1

chr7:7613827

chr7:975141

ENST00000265846

129_230

375.0

Domain

PH 1

Tgene

ADAP1

chr7:7613827

chr7:975141

ENST00000265846

252_356

375.0

Domain

PH 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ADAP1

chr7:7613827

chr7:975141

ENST00000265846

7_126

375.0

Domain

Arf-GAP

Tgene

ADAP1

chr7:7613827

chr7:975141

ENST00000265846

21_44

375.0

Zinc finger

C4-type

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Fusion Gene Sequence for MIOS-ADAP1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>53739_53739_1_MIOS-ADAP1_MIOS_chr7_7613827_ENST00000340080_ADAP1_chr7_975141_ENST00000265846_length(transcript)=3875nt_BP=1814nt
GCTGGGAAACTCCCCTTCCAAGGCCGAGGCGCCGCTGCGCGTCCTCCAGGCGTGGTGGTGGGGTCGTGGGTCCCAGCCCAGTGGTCCAGG
TCACGGGCCGCACGGCCGCGGCCGCCATCTTGCCCGCGTCCGGGCTCCTGCGGCGGGCGGGGCGGTGTCCCGGCCGGAAGCGGCTGTGCG
GCGGCCGCGCTGCCACCTCAGGGAAATTTGGATATGTGCAGTGCATCTCCTCGAAGATGCTGATGGTGGAAATTTCTTGAAACCGCTCTC
GTAATTTGCCACGTGCTGTTGCAAATATTCTGGTGAATGAACACAGAATCAGCATGGCTTTCCTTTGCTGAGAAATCACTGATGGGAAGT
GAGACTTGTTAAACTTGAAAGTGAATGGACCTGAGTGGACCCTTTGATCACATCAGTAAACATGAGCGGTACCAAACCTGATATTTTATG
GGCACCACACCATGTTGATAGATTTGTTGTGTGTGACTCAGAACTAAGTCTTTATCATGTGGAATCTACTGTGAATTCAGAACTCAAAGC
TGGATCTTTACGTTTATCTGAAGACTCTGCAGCTACATTACTGTCAATAAATTCAGATACACCCTATATGAAATGTGTTGCCTGGTATCT
TAATTATGATCCTGAATGTCTGCTGGCAGTTGGACAAGCAAATGGTCGAGTTGTACTTACAAGCCTTGGTCAAGATCATAACTCAAAGTT
CAAAGATTTGATAGGAAAAGAGTTTGTTCCAAAACATGCACGACAATGTAATACCCTTGCCTGGAATCCACTGGATAGTAACTGGCTAGC
TGCTGGTTTAGATAAGCACAGAGCTGACTTTTCAGTGCTAATATGGGATATCTGCAGCAAATATACTCCTGATATAGTTCCCATGGAAAA
AGTGAAACTTTCAGCAGGTGAAACTGAAACAACATTATTAGTAACAAAACCACTTTATGAGTTAGGACAGAATGATGCTTGTCTGTCTCT
TTGTTGGCTTCCACGAGACCAGAAACTTCTCCTTGCTGGTATGCATCGTAACCTAGCTATATTTGATCTTCGGAATACAAGCCAAAAGAT
GTTCGTAAATACAAAAGCTGTTCAGGGTGTGACGGTAGACCCATATTTCCACGATCGTGTTGCTTCCTTCTATGAAGGTCAGGTTGCAAT
ATGGGATCTTAGAAAATTTGAGAAGCCAGTTTTGACATTGACTGAGCAACCAAAACCCTTAACAAAAGTAGCATGGTGTCCCACTAGGAC
TGGTCTACTTGCCACTTTAACAAGGGATAGTAATATTATTAGATTGTATGATATGCAGCATACACCCACTCCCATTGGGGATGAAACTGA
ACCCACAATAATTGAAAGAAGTGTGCAACCTTGTGACAATTACATTGCTTCCTTTGCGTGGCATCCAACAAGTCAAAATCGAATGATAGT
TGTAACTCCCAACCGAACAATGTCAGACTTCACTGTTTTTGAAAGGATATCTCTTGCCTGGAGCCCAATTACATCTTTAATGTGGGCTTG
TGGTCGTCATTTATATGAATGTACGGAAGAAGAAAATGATAATTCTTTAGAAAAAGATATAGCAACGAAGATGCGTCTTCGGGCTTTATC
AAGGTATGGACTTGATACAGAGCAGGTGTGGAGGAACCACATTTTAGCTGGAAATGAAGATCCACAGCTCAAGTCACTCTGGTATACTCT
GCACTTTATGAAGCAATACACAGAAGATATGGATCAGAAATCTCCAGGCAACAAAGGATCATTGGTTTATGCAGGAATTAAATCAATTGT
AAAGTCATCGTTGGATCCCGACTGGGCCTCCTACACTCTGGGCGTCTTCATCTGCCTGAGCTGCTCGGGAATCCACCGGAATATCCCCCA
GGTCAGCAAGGTGAAGTCCGTCCGCCTGGACGCCTGGGAGGAGGCCCAAGTGGAGTTCATGGCCTCCCACGGGAACGACGCCGCGAGAGC
CAGGTTTGAGTCCAAAGTACCCTCCTTCTACTACCGGCCCACGCCCTCCGACTGCCAGCTCCTTCGAGAGCAGTGGATCCGGGCCAAGTA
CGAGCGACAGGAGTTCATCTACCCGGAGAAGCAGGAGCCCTACTCGGCAGGGTACCGTGAGGGTTTTCTCTGGAAGCGTGGCCGGGACAA
CGGGCAGTTTTTGAGCCGGAAGTTTGTGCTGACAGAACGAGAGGGTGCTCTGAAGTATTTCAACAGAAATGATGCCAAGGAGCCCAAGGC
CGTGATGAAGATCGAGCACCTGAACGCCACCTTCCAGCCGGCCAAGATCGGCCACCCCCACGGCCTGCAGGTCACCTACCTGAAGGACAA
CAGCACCCGTAACATCTTCATCTACCATGAGGACGGGAAGGAGATTGTGGACTGGTTCAATGCACTCCGAGCTGCTCGCTTCCACTACCT
GCAGGTGGCATTCCCAGGGGCCGGCGACGCAGATCTGGTGCCAAAGCTCTCCAGGAACTACCTGAAGGAAGGCTACATGGAGAAGACGGG
GCCCAAGCAAACGGAAGGCTTCCGGAAGCGCTGGTTCACCATGGATGACCGCAGGCTCATGTACTTCAAAGACCCCCTGGACGCCTTCGC
CCGAGGGGAAGTCTTCATTGGCAGCAAGGAGAGTGGCTACACGGTGCTGCATGGGTTCCCGCCGTCCACCCAGGGCCACCACTGGCCACA
TGGCATCACCATCGTCACGCCCGACCGCAAGTTTCTGTTTGCCTGCGAGACGGAGTCCGACCAGAGGGAGTGGGTGGCGGCCTTCCAGAA
GGCGGTGGACAGGCCCATGCTGCCCCAGGAGTACGCAGTGGAGGCGCACTTCAAGCATAAACCTTAGCGAGTGCGGCTGGAGGACCACGG
ACATTGGACTCACTGTGGCTGGACGGAGGGGACCCGTGGATGGGGGGGCTCTGGCGTCCTGAGGCCACCTGGCCCCACCTGCTCCTCAGG
GCAGCCCGGCGCGGCCAGGTAGGGCCCGAGCTTCAGCTTCCAGGATGCTTCTCTGGAACCTCAAGGCAGGCAGCCCAGGCCCTGGGCCTG
ATCTCTAACCCCGTCATGCTGCTGCTGACCACACCCAGCCAACCTGCCCCTCCCTGACCCGGGGCCCCCTTTCCTCCAGGGCCCAGTCTG
GCTCCCGAGCTCAGACACAGCCCCCAGGAGCCGCCCACCACGGCTGTGGGAACTTCCAGGCCTCAGCGCAGAGCCCTGCTTGGGGCCAGC
ACGGTGGGCAGCTGCCGGCCGCTGGGGACTGGGCCCTGCTCGCATGCCGCCCCGCCCTCCCCCCACCTCCACGACTATTTATTGAGCGCC
TGTTGTGTGTCACGGGGCTATGAGGGCCGTGGGGTGTTTGGGTGGATTATCCACACAGGTCCCGGCCCCTGCCCGGGCTGGAGTTGCCAC
AGCCTGTGCTCCTGGTCCTCACCTGGAGGGGCCAGCAGGCTGCCGTCCCACCACACGTGGCCTCTGCGCCCAGCACGGTGCTCGCCGACA
GTGGTGTCTGAACCCTTGGGGACGAGGGCCTGGGCCGCGGTGAGGCCACCAGAGGCAGGAGTGGCCCTGGGGGTCCCGGGCACTGTCGCG
CTTGCTGCAGGCGGCCCAGCCGTGTATTTATTTTTCACCTATCTCCTTCCTGTCAAGGCAGGCCGGGCTCCAGGGCTCCCCTTGCGTGGG
GCATGTAGGTGGGGGAGGCGTCTGCAGGTCACCTGGGGGGCCCAGCCCTCTCCCAGCCTTGCCTGGCTGAGCTGTGTTCCAGGGGAGCCC
TGGACAAGCCCTCATAGGCAGGGAGGGGGTTTCCGAGGCCAGGCATCCGCCGCCCCGTGTCGCATCCTGGAATAAAATGTGGCTCTGGCA

>53739_53739_1_MIOS-ADAP1_MIOS_chr7_7613827_ENST00000340080_ADAP1_chr7_975141_ENST00000265846_length(amino acids)=817AA_BP=470
MITSVNMSGTKPDILWAPHHVDRFVVCDSELSLYHVESTVNSELKAGSLRLSEDSAATLLSINSDTPYMKCVAWYLNYDPECLLAVGQAN
GRVVLTSLGQDHNSKFKDLIGKEFVPKHARQCNTLAWNPLDSNWLAAGLDKHRADFSVLIWDICSKYTPDIVPMEKVKLSAGETETTLLV
TKPLYELGQNDACLSLCWLPRDQKLLLAGMHRNLAIFDLRNTSQKMFVNTKAVQGVTVDPYFHDRVASFYEGQVAIWDLRKFEKPVLTLT
EQPKPLTKVAWCPTRTGLLATLTRDSNIIRLYDMQHTPTPIGDETEPTIIERSVQPCDNYIASFAWHPTSQNRMIVVTPNRTMSDFTVFE
RISLAWSPITSLMWACGRHLYECTEEENDNSLEKDIATKMRLRALSRYGLDTEQVWRNHILAGNEDPQLKSLWYTLHFMKQYTEDMDQKS
PGNKGSLVYAGIKSIVKSSLDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARARFESKVPSFYYRPT
PSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRNDAKEPKAVMKIEHLNATFQPA
KIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGAGDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTM
DDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKFLFACETESDQREWVAAFQKAVDRPMLPQEYAVE

--------------------------------------------------------------
>53739_53739_2_MIOS-ADAP1_MIOS_chr7_7613827_ENST00000405785_ADAP1_chr7_975141_ENST00000265846_length(transcript)=3790nt_BP=1729nt
GGGAAACTCCCCTTCCAAGGCCGAGGCGCCGCTGCGCGTCCTCCAGGCGTGGTGGTGGGGTCGTGGGTCCCAGCCCAGTGGTCCAGGTCA
CGGGCCGCACGGCCGCGGCCGCCATCTTGCCCGCGTCCGGGCTCCTGCGGCGGGCGGGGCGGTGTCCCGGCCGGAAGCGGCTGTGCGGCG
GCCGCGCTGCCACCTCAGTGCTGTTGCAAATATTCTGGTGAATGAACACAGAATCAGCATGGCTTTCCTTTGCTGAGAAATCACTGATGG
GAAGTGAGACTTGTTAAACTTGAAAGTGAATGGACCTGAGTGGACCCTTTGATCACATCAGTAAACATGAGCGGTACCAAACCTGATATT
TTATGGGCACCACACCATGTTGATAGATTTGTTGTGTGTGACTCAGAACTAAGTCTTTATCATGTGGAATCTACTGTGAATTCAGAACTC
AAAGCTGGATCTTTACGTTTATCTGAAGACTCTGCAGCTACATTACTGTCAATAAATTCAGATACACCCTATATGAAATGTGTTGCCTGG
TATCTTAATTATGATCCTGAATGTCTGCTGGCAGTTGGACAAGCAAATGGTCGAGTTGTACTTACAAGCCTTGGTCAAGATCATAACTCA
AAGTTCAAAGATTTGATAGGAAAAGAGTTTGTTCCAAAACATGCACGACAATGTAATACCCTTGCCTGGAATCCACTGGATAGTAACTGG
CTAGCTGCTGGTTTAGATAAGCACAGAGCTGACTTTTCAGTGCTAATATGGGATATCTGCAGCAAATATACTCCTGATATAGTTCCCATG
GAAAAAGTGAAACTTTCAGCAGGTGAAACTGAAACAACATTATTAGTAACAAAACCACTTTATGAGTTAGGACAGAATGATGCTTGTCTG
TCTCTTTGTTGGCTTCCACGAGACCAGAAACTTCTCCTTGCTGGTATGCATCGTAACCTAGCTATATTTGATCTTCGGAATACAAGCCAA
AAGATGTTCGTAAATACAAAAGCTGTTCAGGGTGTGACGGTAGACCCATATTTCCACGATCGTGTTGCTTCCTTCTATGAAGGTCAGGTT
GCAATATGGGATCTTAGAAAATTTGAGAAGCCAGTTTTGACATTGACTGAGCAACCAAAACCCTTAACAAAAGTAGCATGGTGTCCCACT
AGGACTGGTCTACTTGCCACTTTAACAAGGGATAGTAATATTATTAGATTGTATGATATGCAGCATACACCCACTCCCATTGGGGATGAA
ACTGAACCCACAATAATTGAAAGAAGTGTGCAACCTTGTGACAATTACATTGCTTCCTTTGCGTGGCATCCAACAAGTCAAAATCGAATG
ATAGTTGTAACTCCCAACCGAACAATGTCAGACTTCACTGTTTTTGAAAGGATATCTCTTGCCTGGAGCCCAATTACATCTTTAATGTGG
GCTTGTGGTCGTCATTTATATGAATGTACGGAAGAAGAAAATGATAATTCTTTAGAAAAAGATATAGCAACGAAGATGCGTCTTCGGGCT
TTATCAAGGTATGGACTTGATACAGAGCAGGTGTGGAGGAACCACATTTTAGCTGGAAATGAAGATCCACAGCTCAAGTCACTCTGGTAT
ACTCTGCACTTTATGAAGCAATACACAGAAGATATGGATCAGAAATCTCCAGGCAACAAAGGATCATTGGTTTATGCAGGAATTAAATCA
ATTGTAAAGTCATCGTTGGATCCCGACTGGGCCTCCTACACTCTGGGCGTCTTCATCTGCCTGAGCTGCTCGGGAATCCACCGGAATATC
CCCCAGGTCAGCAAGGTGAAGTCCGTCCGCCTGGACGCCTGGGAGGAGGCCCAAGTGGAGTTCATGGCCTCCCACGGGAACGACGCCGCG
AGAGCCAGGTTTGAGTCCAAAGTACCCTCCTTCTACTACCGGCCCACGCCCTCCGACTGCCAGCTCCTTCGAGAGCAGTGGATCCGGGCC
AAGTACGAGCGACAGGAGTTCATCTACCCGGAGAAGCAGGAGCCCTACTCGGCAGGGTACCGTGAGGGTTTTCTCTGGAAGCGTGGCCGG
GACAACGGGCAGTTTTTGAGCCGGAAGTTTGTGCTGACAGAACGAGAGGGTGCTCTGAAGTATTTCAACAGAAATGATGCCAAGGAGCCC
AAGGCCGTGATGAAGATCGAGCACCTGAACGCCACCTTCCAGCCGGCCAAGATCGGCCACCCCCACGGCCTGCAGGTCACCTACCTGAAG
GACAACAGCACCCGTAACATCTTCATCTACCATGAGGACGGGAAGGAGATTGTGGACTGGTTCAATGCACTCCGAGCTGCTCGCTTCCAC
TACCTGCAGGTGGCATTCCCAGGGGCCGGCGACGCAGATCTGGTGCCAAAGCTCTCCAGGAACTACCTGAAGGAAGGCTACATGGAGAAG
ACGGGGCCCAAGCAAACGGAAGGCTTCCGGAAGCGCTGGTTCACCATGGATGACCGCAGGCTCATGTACTTCAAAGACCCCCTGGACGCC
TTCGCCCGAGGGGAAGTCTTCATTGGCAGCAAGGAGAGTGGCTACACGGTGCTGCATGGGTTCCCGCCGTCCACCCAGGGCCACCACTGG
CCACATGGCATCACCATCGTCACGCCCGACCGCAAGTTTCTGTTTGCCTGCGAGACGGAGTCCGACCAGAGGGAGTGGGTGGCGGCCTTC
CAGAAGGCGGTGGACAGGCCCATGCTGCCCCAGGAGTACGCAGTGGAGGCGCACTTCAAGCATAAACCTTAGCGAGTGCGGCTGGAGGAC
CACGGACATTGGACTCACTGTGGCTGGACGGAGGGGACCCGTGGATGGGGGGGCTCTGGCGTCCTGAGGCCACCTGGCCCCACCTGCTCC
TCAGGGCAGCCCGGCGCGGCCAGGTAGGGCCCGAGCTTCAGCTTCCAGGATGCTTCTCTGGAACCTCAAGGCAGGCAGCCCAGGCCCTGG
GCCTGATCTCTAACCCCGTCATGCTGCTGCTGACCACACCCAGCCAACCTGCCCCTCCCTGACCCGGGGCCCCCTTTCCTCCAGGGCCCA
GTCTGGCTCCCGAGCTCAGACACAGCCCCCAGGAGCCGCCCACCACGGCTGTGGGAACTTCCAGGCCTCAGCGCAGAGCCCTGCTTGGGG
CCAGCACGGTGGGCAGCTGCCGGCCGCTGGGGACTGGGCCCTGCTCGCATGCCGCCCCGCCCTCCCCCCACCTCCACGACTATTTATTGA
GCGCCTGTTGTGTGTCACGGGGCTATGAGGGCCGTGGGGTGTTTGGGTGGATTATCCACACAGGTCCCGGCCCCTGCCCGGGCTGGAGTT
GCCACAGCCTGTGCTCCTGGTCCTCACCTGGAGGGGCCAGCAGGCTGCCGTCCCACCACACGTGGCCTCTGCGCCCAGCACGGTGCTCGC
CGACAGTGGTGTCTGAACCCTTGGGGACGAGGGCCTGGGCCGCGGTGAGGCCACCAGAGGCAGGAGTGGCCCTGGGGGTCCCGGGCACTG
TCGCGCTTGCTGCAGGCGGCCCAGCCGTGTATTTATTTTTCACCTATCTCCTTCCTGTCAAGGCAGGCCGGGCTCCAGGGCTCCCCTTGC
GTGGGGCATGTAGGTGGGGGAGGCGTCTGCAGGTCACCTGGGGGGCCCAGCCCTCTCCCAGCCTTGCCTGGCTGAGCTGTGTTCCAGGGG
AGCCCTGGACAAGCCCTCATAGGCAGGGAGGGGGTTTCCGAGGCCAGGCATCCGCCGCCCCGTGTCGCATCCTGGAATAAAATGTGGCTC

>53739_53739_2_MIOS-ADAP1_MIOS_chr7_7613827_ENST00000405785_ADAP1_chr7_975141_ENST00000265846_length(amino acids)=817AA_BP=470
MITSVNMSGTKPDILWAPHHVDRFVVCDSELSLYHVESTVNSELKAGSLRLSEDSAATLLSINSDTPYMKCVAWYLNYDPECLLAVGQAN
GRVVLTSLGQDHNSKFKDLIGKEFVPKHARQCNTLAWNPLDSNWLAAGLDKHRADFSVLIWDICSKYTPDIVPMEKVKLSAGETETTLLV
TKPLYELGQNDACLSLCWLPRDQKLLLAGMHRNLAIFDLRNTSQKMFVNTKAVQGVTVDPYFHDRVASFYEGQVAIWDLRKFEKPVLTLT
EQPKPLTKVAWCPTRTGLLATLTRDSNIIRLYDMQHTPTPIGDETEPTIIERSVQPCDNYIASFAWHPTSQNRMIVVTPNRTMSDFTVFE
RISLAWSPITSLMWACGRHLYECTEEENDNSLEKDIATKMRLRALSRYGLDTEQVWRNHILAGNEDPQLKSLWYTLHFMKQYTEDMDQKS
PGNKGSLVYAGIKSIVKSSLDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARARFESKVPSFYYRPT
PSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRNDAKEPKAVMKIEHLNATFQPA
KIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGAGDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTM
DDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKFLFACETESDQREWVAAFQKAVDRPMLPQEYAVE

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Fusion Gene PPI Analysis for MIOS-ADAP1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MIOS-ADAP1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MIOS-ADAP1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source