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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MIPEP-TNFRSF19 (FusionGDB2 ID:53749)

Fusion Gene Summary for MIPEP-TNFRSF19

Fusion gene summary

Fusion gene information	Fusion gene name: MIPEP-TNFRSF19
	Fusion gene ID: 53749
		Hgene	Tgene
	Gene symbol	MIPEP	TNFRSF19
	Gene ID	4285	55504
	Gene name	mitochondrial intermediate peptidase	TNF receptor superfamily member 19
	Synonyms	COXPD31\|HMIP\|MIP	TAJ\|TAJ-alpha\|TRADE\|TROY
	Cytomap	13q12.12	13q12.12
	Type of gene	protein-coding	protein-coding
	Description	mitochondrial intermediate peptidase	tumor necrosis factor receptor superfamily member 19toxicity and JNK inducer
	Modification date	20200313	20200313
	UniProtAcc	Q99797	.
	Ensembl transtripts involved in fusion gene	ENST00000382172, ENST00000469167,	ENST00000403372, ENST00000382258, ENST00000464735, ENST00000248484, ENST00000382263,
Fusion gene scores	* DoF score	7 X 7 X 6=294	7 X 6 X 6=252
	# samples	7	8
	** MAII score	log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/252*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MIPEP [Title/Abstract] AND TNFRSF19 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MIPEP(24410379)-TNFRSF19(24190006), # samples:1 TNFRSF19(24200931)-MIPEP(24330757), # samples:1
Anticipated loss of major functional domain due to fusion event.	TNFRSF19-MIPEP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TNFRSF19-MIPEP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. TNFRSF19-MIPEP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MIPEP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TNFRSF19 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-EJ-5497-01A	MIPEP	chr13	24410379	-	TNFRSF19	chr13	24190006	+

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Fusion Gene ORF analysis for MIPEP-TNFRSF19

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000382172	ENST00000403372	MIPEP	chr13	24410379	-	TNFRSF19	chr13	24190006	+
5CDS-intron	ENST00000382172	ENST00000382258	MIPEP	chr13	24410379	-	TNFRSF19	chr13	24190006	+
5CDS-intron	ENST00000382172	ENST00000464735	MIPEP	chr13	24410379	-	TNFRSF19	chr13	24190006	+
In-frame	ENST00000382172	ENST00000248484	MIPEP	chr13	24410379	-	TNFRSF19	chr13	24190006	+
In-frame	ENST00000382172	ENST00000382263	MIPEP	chr13	24410379	-	TNFRSF19	chr13	24190006	+
intron-3CDS	ENST00000469167	ENST00000248484	MIPEP	chr13	24410379	-	TNFRSF19	chr13	24190006	+
intron-3CDS	ENST00000469167	ENST00000382263	MIPEP	chr13	24410379	-	TNFRSF19	chr13	24190006	+
intron-5UTR	ENST00000469167	ENST00000403372	MIPEP	chr13	24410379	-	TNFRSF19	chr13	24190006	+
intron-intron	ENST00000469167	ENST00000382258	MIPEP	chr13	24410379	-	TNFRSF19	chr13	24190006	+
intron-intron	ENST00000469167	ENST00000464735	MIPEP	chr13	24410379	-	TNFRSF19	chr13	24190006	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000382172

MIPEP

chr13

24410379

ENST00000248484

TNFRSF19

chr13

24190006

4335

1752

2825

938

ENST00000382172

MIPEP

chr13

24410379

ENST00000382263

TNFRSF19

chr13

24190006

5539

1752

2825

938

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000382172	ENST00000248484	MIPEP	chr13	24410379	-	TNFRSF19	chr13	24190006	+	0.002135992	0.99786407
ENST00000382172	ENST00000382263	MIPEP	chr13	24410379	-	TNFRSF19	chr13	24190006	+	0.001118403	0.99888164

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Fusion Genomic Features for MIPEP-TNFRSF19

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MIPEP-TNFRSF19

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:24410379/chr13:24190006)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MIPEP Q99797	.
FUNCTION: Cleaves proteins, imported into the mitochondrion, to their mature size.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000248484

116_149

418.0

Repeat

Note=TNFR-Cys 3

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000248484

74_114

418.0

Repeat

Note=TNFR-Cys 2

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000382258

116_149

424.0

Repeat

Note=TNFR-Cys 3

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000382258

74_114

424.0

Repeat

Note=TNFR-Cys 2

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000382263

116_149

418.0

Repeat

Note=TNFR-Cys 3

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000382263

74_114

418.0

Repeat

Note=TNFR-Cys 2

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000403372

116_149

286.0

Repeat

Note=TNFR-Cys 3

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000403372

33_72

286.0

Repeat

Note=TNFR-Cys 1

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000403372

74_114

286.0

Repeat

Note=TNFR-Cys 2

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000248484

192_423

418.0

Topological domain

Cytoplasmic

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000382258

192_423

424.0

Topological domain

Cytoplasmic

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000382263

192_423

418.0

Topological domain

Cytoplasmic

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000403372

192_423

286.0

Topological domain

Cytoplasmic

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000403372

30_170

286.0

Topological domain

Extracellular

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000248484

171_191

418.0

Transmembrane

Helical

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000382258

171_191

424.0

Transmembrane

Helical

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000382263

171_191

418.0

Transmembrane

Helical

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000403372

171_191

286.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000248484

33_72

418.0

Repeat

Note=TNFR-Cys 1

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000382258

33_72

424.0

Repeat

Note=TNFR-Cys 1

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000382263

33_72

418.0

Repeat

Note=TNFR-Cys 1

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000248484

30_170

418.0

Topological domain

Extracellular

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000382258

30_170

424.0

Topological domain

Extracellular

Tgene

TNFRSF19

chr13:24410379

chr13:24190006

ENST00000382263

30_170

418.0

Topological domain

Extracellular

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Fusion Gene Sequence for MIPEP-TNFRSF19

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>53749_53749_1_MIPEP-TNFRSF19_MIPEP_chr13_24410379_ENST00000382172_TNFRSF19_chr13_24190006_ENST00000248484_length(transcript)=4335nt_BP=1752nt
CGGCGTGGGCTGCTGCCTTGGAAACGCGGAGCGCGCGCTCCCAGCGAAAGCAGCAGGGCAGGGATCTGCGTTGGAGGAAGGGACTGCTCT
GGTGCTAGAATGCTGTGCGTCGGAAGGCTGGGCGGCTTGGGAGCCAGAGCAGCAGCTCTGCCGCCCCGCCGGGCGGGCCGGGGAAGCCTC
GAAGCCGGGATCCGGGCCCGAAGGGTCAGCACCAGCTGGTCTCCCGTGGGCGCCGCCTTCAATGTCAAGCCCCAGGGCAGCCGCTTGGAC
CTGTTCGGCGAGCGCCGGGGTCTTTTTGGAGTTCCTGAGCTGAGTGCCCCAGAAGGATTTCATATTGCACAAGAAAAAGCCTTGAGAAAG
ACAGAATTGCTTGTGGACCGTGCATGTTCCACCCCACCTGGGCCCCAGACCGTGCTGATCTTCGATGAGCTCTCGGATTCCTTATGCAGA
GTGGCCGACTTGGCTGATTTTGTGAAAATCGCTCACCCTGAGCCAGCATTCAGAGAAGCTGCGGAAGAAGCTTGTAGAAGTATTGGCACC
ATGGTAGAGAAGTTGAACACAAATGTGGATTTATATCAAAGTTTGCAAAAATTACTAGCTGATAAAAAACTTGTGGATTCCCTTGATCCA
GAAACAAGGCGAGTGGCTGAACTGTTTATGTTTGATTTTGAAATTAGTGGAATCCATCTAGACAAAGAAAAGCGTAAAAGAGCAGTGGAC
CTCAATGTTAAAATCTTGGATTTGAGTAGTACATTTCTTATGGGAACCAATTTTCCCAACAAGATTGAGAAGCATCTCTTACCAGAACAC
ATTCGTCGTAACTTTACATCTGCTGGGGATCATATCATAATTGATGGTCTCCACGCAGAATCACCAGATGACTTGGTGCGAGAAGCTGCT
TATAAAATTTTTCTTTATCCCAATGCTGGTCAATTGAAATGTTTAGAAGAATTGCTCAGCAGCAGAGATCTTCTGGCAAAGTTGGTGGGG
TATTCCACGTTTTCTCACAGGGCTCTCCAAGGAACGATAGCTAAAAATCCAGAGACTGTCATGCAGTTCCTTGAAAAACTATCTGACAAA
CTTTCTGAAAGAACTCTGAAAGATTTTGAGATGATACGAGGGATGAAAATGAAACTGAATCCTCAAAATTCCGAAGTAATGCCCTGGGAC
CCCCCTTACTACAGTGGTGTGATTCGTGCAGAAAGGTATAATATTGAGCCCAGCCTATATTGCCCGTTTTTCTCTCTTGGAGCATGCATG
GAAGGCCTGAATATTTTGCTTAACAGACTGTTGGGGATTTCATTATATGCAGAGCAGCCTGCAAAAGGAGAGGTGTGGAGCGAAGATGTC
CGAAAACTGGCTGTTGTTCATGAATCTGAAGGATTGTTGGGGTACATTTACTGTGATTTTTTTCAGCGAGCAGACAAACCACATCAGGAT
TGCCATTTCACTATCCGTGGAGGCAGACTAAAGGAAGATGGAGACTATCAACTCCCAGTTGTAGTTCTTATGCTGAATCTTCCCCGTTCC
TCAAGGAGTTCTCCAACTTTGCTAACTCCTAGCATGATGGAAAATCTTTTCCATGAAATGGGACATGCCATGCATTCAATGCTAGGACGT
ACTCGTTACCAACACGTCACTGGGACCAGGTGCCCTACTGATTTTGCTGAGGTTCCTTCTATTCTGATGGAGTACTTTGCAAATGATTAT
CGAGTAGTTAACCAATTTGCCAGACATTATCAGACTGGACAGGAATGTGGCTTCGGCTATGGGGAGGATGCACAGTGTGTGACGTGCCGG
CTGCACAGGTTCAAGGAGGACTGGGGCTTCCAGAAATGCAAGCCCTGTCTGGACTGCGCAGTGGTGAACCGCTTTCAGAAGGCAAATTGT
TCAGCCACCAGTGATGCCATCTGCGGGGACTGCTTGCCAGGATTTTATAGGAAGACGAAACTTGTCGGCTTTCAAGACATGGAGTGTGTG
CCTTGTGGAGACCCTCCTCCTCCTTACGAACCGCACTGTGCCAGCAAGGTCAACCTCGTGAAGATCGCGTCCACGGCCTCCAGCCCACGG
GACACGGCGCTGGCTGCCGTTATCTGCAGCGCTCTGGCCACCGTCCTGCTGGCCCTGCTCATCCTCTGTGTCATCTATTGTAAGAGACAG
TTTATGGAGAAGAAACCCAGCTGGTCTCTGCGGTCACAGGACATTCAGTACAACGGCTCTGAGCTGTCGTGTTTTGACAGACCTCAGCTC
CACGAATATGCCCACAGAGCCTGCTGCCAGTGCCGCCGTGACTCAGTGCAGACCTGCGGGCCGGTGCGCTTGCTCCCATCCATGTGCTGT
GAGGAGGCCTGCAGCCCCAACCCGGCGACTCTTGGTTGTGGGGTGCATTCTGCAGCCAGTCTTCAGGCAAGAAACGCAGGCCCAGCCGGG
GAGATGGTGCCGACTTTCTTCGGATCCCTCACGCAGTCCATCTGTGGCGAGTTTTCAGATGCCTGGCCTCTGATGCAGAATCCCATGGGT
GGTGACAACATCTCTTTTTGTGACTCTTATCCTGAACTCACTGGAGAAGACATTCATTCTCTCAATCCAGAACTTGAAAGCTCAACGTCT
TTGGATTCAAATAGCAGTCAAGATTTGGTTGGTGGGGCTGTTCCAGTCCAGTCTCATTCTGAAAACTTTACAGCAGCTACTGATTTATCT
AGATATAACAACACACTGGTAGAATCAGCATCAACTCAGGATGCACTAACTATGAGAAGCCAGCTAGATCAGGAGAGTGGTGCTGTCATC
CACCCAGCCACTCAGACGTCCCTCCAGGAAGCTTAAAGAACCTGCTTCTTTCTGCAGTAGAAGCGTGTGCTGGAACCCAAAGAGTACTCC
TTTGTTAGGCTTATGGACTGAGCAGTCTGGACCTTGCATGGCTTCTGGGGCAAAAATAAATCTGAACCAAACTGACGGCATTTGAAGCCT
TTCAGCCAGTTGCTTCTGAGCCAGACCAGCTGTAAGCTGAAACCTCAATGAATAACAAGAAAAGACTCCAGGCCGACTCATGATACTCTG
CATCTTTCCTACATGAGAAGCTTCTCTGCCACAAAAGTGACTTCAAAGACGGATGGGTTGAGCTGGCAGCCTATGAGATTGTGGACATAT
AACAAGAAACAGAAATGCCCTCATGCTTATTTTCATGGTGATTGTGGTTTTACAAGACTGAAGACCCAGAGTATACTTTTTCTTTCCAGA
AATAATTTCATACCGCCTATGAAATATCAGATAAATTACCTTAGCTTTTATGTAGAATGGGTTCAAAAGTGAGTGTTTCTATTTGAGAAG
GACACTTTTTCATCATCTAAACTGATTCGCATAGGTGGTTAGAATGGCCCTCATATTGCCTGCCTAAATCTTGGGTTTATTAGATGAAGT
TTACTGAATCAGAGGAATCAGACAGAGGAGGATAGCTCTTTCCAGAATCCACACTTCTGACCTCAGCCTCGGTCTCATGAACACCCGCTG
ATCTCAGGAGAACACCTGGGCTAGGGAATGTGGTCGAGAAAGGGCAGCCCATTGCCCAGAATTAACACATATTGTAGAGACTTGTATGCA
AAGGTTGGCATATTTATATGAAAATTAGTTGCTATAGAAACATTTGTTGCATCTGTCCCTCTGCCTGAGCTTAGAAGGTTATAGAAAAAG
GGTATTTATAAACATAAATGACCTTTTACTTGCATTGTATCTTATACTAAAGGCTTTAGAAATTACAACATATCAGGTTCCCCTACTACT
GAAGTAGCCTTCCGTGAGAACACACCACATGTTAGGACTAGAAGAAAATGCACAATTTGTAGGGGTTTGGATGAAGCAGCTGTAACTGCC
CTAGTGTAGTTTGACCAGGACATTGTCGTGCTCCTTCCAATTGTGTAAGATTAGTTAGCACATCATCTCCTACTTTAGCCATCCGGTGTT
GGATTTAAGAGGACGGTGCTTCTTTCTATTAAAGTGCTCCATCCCCTACCATCTACACATTAGCATTGTCTCTAGAGCTAAGACAGAAAT
TAACCCCGTTCAGTCACAAAGCAGGGAATGGTTCATTTACTCTTAATCTTTATGCCCTGGAGAAGACCTACTTGAACAGGGCATATTTTT
TAGACTTCTGAACATCAGTATGTTCGAGGGTACTATGATATTTTGGTTTGGAATTGCCCTGCCCAAGTCACTGTCTTTTAACTTTTAAAC
TGAATATTAAAATGTATCTGTCTTTCCTAGTATGTTTTTATCTTCTCATGTATTATCCATGGTTTTCTCTGTTTGTGACAGATTAGTAAA

>53749_53749_1_MIPEP-TNFRSF19_MIPEP_chr13_24410379_ENST00000382172_TNFRSF19_chr13_24190006_ENST00000248484_length(amino acids)=938AA_BP=37
MLPWKRGARAPSESSRAGICVGGRDCSGARMLCVGRLGGLGARAAALPPRRAGRGSLEAGIRARRVSTSWSPVGAAFNVKPQGSRLDLFG
ERRGLFGVPELSAPEGFHIAQEKALRKTELLVDRACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVE
KLNTNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLDKEKRKRAVDLNVKILDLSSTFLMGTNFPNKIEKHLLPEHIRR
NFTSAGDHIIIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYSTFSHRALQGTIAKNPETVMQFLEKLSDKLSE
RTLKDFEMIRGMKMKLNPQNSEVMPWDPPYYSGVIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKL
AVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRSSPTLLTPSMMENLFHEMGHAMHSMLGRTRY
QHVTGTRCPTDFAEVPSILMEYFANDYRVVNQFARHYQTGQECGFGYGEDAQCVTCRLHRFKEDWGFQKCKPCLDCAVVNRFQKANCSAT
SDAICGDCLPGFYRKTKLVGFQDMECVPCGDPPPPYEPHCASKVNLVKIASTASSPRDTALAAVICSALATVLLALLILCVIYCKRQFME
KKPSWSLRSQDIQYNGSELSCFDRPQLHEYAHRACCQCRRDSVQTCGPVRLLPSMCCEEACSPNPATLGCGVHSAASLQARNAGPAGEMV
PTFFGSLTQSICGEFSDAWPLMQNPMGGDNISFCDSYPELTGEDIHSLNPELESSTSLDSNSSQDLVGGAVPVQSHSENFTAATDLSRYN

--------------------------------------------------------------
>53749_53749_2_MIPEP-TNFRSF19_MIPEP_chr13_24410379_ENST00000382172_TNFRSF19_chr13_24190006_ENST00000382263_length(transcript)=5539nt_BP=1752nt
CGGCGTGGGCTGCTGCCTTGGAAACGCGGAGCGCGCGCTCCCAGCGAAAGCAGCAGGGCAGGGATCTGCGTTGGAGGAAGGGACTGCTCT
GGTGCTAGAATGCTGTGCGTCGGAAGGCTGGGCGGCTTGGGAGCCAGAGCAGCAGCTCTGCCGCCCCGCCGGGCGGGCCGGGGAAGCCTC
GAAGCCGGGATCCGGGCCCGAAGGGTCAGCACCAGCTGGTCTCCCGTGGGCGCCGCCTTCAATGTCAAGCCCCAGGGCAGCCGCTTGGAC
CTGTTCGGCGAGCGCCGGGGTCTTTTTGGAGTTCCTGAGCTGAGTGCCCCAGAAGGATTTCATATTGCACAAGAAAAAGCCTTGAGAAAG
ACAGAATTGCTTGTGGACCGTGCATGTTCCACCCCACCTGGGCCCCAGACCGTGCTGATCTTCGATGAGCTCTCGGATTCCTTATGCAGA
GTGGCCGACTTGGCTGATTTTGTGAAAATCGCTCACCCTGAGCCAGCATTCAGAGAAGCTGCGGAAGAAGCTTGTAGAAGTATTGGCACC
ATGGTAGAGAAGTTGAACACAAATGTGGATTTATATCAAAGTTTGCAAAAATTACTAGCTGATAAAAAACTTGTGGATTCCCTTGATCCA
GAAACAAGGCGAGTGGCTGAACTGTTTATGTTTGATTTTGAAATTAGTGGAATCCATCTAGACAAAGAAAAGCGTAAAAGAGCAGTGGAC
CTCAATGTTAAAATCTTGGATTTGAGTAGTACATTTCTTATGGGAACCAATTTTCCCAACAAGATTGAGAAGCATCTCTTACCAGAACAC
ATTCGTCGTAACTTTACATCTGCTGGGGATCATATCATAATTGATGGTCTCCACGCAGAATCACCAGATGACTTGGTGCGAGAAGCTGCT
TATAAAATTTTTCTTTATCCCAATGCTGGTCAATTGAAATGTTTAGAAGAATTGCTCAGCAGCAGAGATCTTCTGGCAAAGTTGGTGGGG
TATTCCACGTTTTCTCACAGGGCTCTCCAAGGAACGATAGCTAAAAATCCAGAGACTGTCATGCAGTTCCTTGAAAAACTATCTGACAAA
CTTTCTGAAAGAACTCTGAAAGATTTTGAGATGATACGAGGGATGAAAATGAAACTGAATCCTCAAAATTCCGAAGTAATGCCCTGGGAC
CCCCCTTACTACAGTGGTGTGATTCGTGCAGAAAGGTATAATATTGAGCCCAGCCTATATTGCCCGTTTTTCTCTCTTGGAGCATGCATG
GAAGGCCTGAATATTTTGCTTAACAGACTGTTGGGGATTTCATTATATGCAGAGCAGCCTGCAAAAGGAGAGGTGTGGAGCGAAGATGTC
CGAAAACTGGCTGTTGTTCATGAATCTGAAGGATTGTTGGGGTACATTTACTGTGATTTTTTTCAGCGAGCAGACAAACCACATCAGGAT
TGCCATTTCACTATCCGTGGAGGCAGACTAAAGGAAGATGGAGACTATCAACTCCCAGTTGTAGTTCTTATGCTGAATCTTCCCCGTTCC
TCAAGGAGTTCTCCAACTTTGCTAACTCCTAGCATGATGGAAAATCTTTTCCATGAAATGGGACATGCCATGCATTCAATGCTAGGACGT
ACTCGTTACCAACACGTCACTGGGACCAGGTGCCCTACTGATTTTGCTGAGGTTCCTTCTATTCTGATGGAGTACTTTGCAAATGATTAT
CGAGTAGTTAACCAATTTGCCAGACATTATCAGACTGGACAGGAATGTGGCTTCGGCTATGGGGAGGATGCACAGTGTGTGACGTGCCGG
CTGCACAGGTTCAAGGAGGACTGGGGCTTCCAGAAATGCAAGCCCTGTCTGGACTGCGCAGTGGTGAACCGCTTTCAGAAGGCAAATTGT
TCAGCCACCAGTGATGCCATCTGCGGGGACTGCTTGCCAGGATTTTATAGGAAGACGAAACTTGTCGGCTTTCAAGACATGGAGTGTGTG
CCTTGTGGAGACCCTCCTCCTCCTTACGAACCGCACTGTGCCAGCAAGGTCAACCTCGTGAAGATCGCGTCCACGGCCTCCAGCCCACGG
GACACGGCGCTGGCTGCCGTTATCTGCAGCGCTCTGGCCACCGTCCTGCTGGCCCTGCTCATCCTCTGTGTCATCTATTGTAAGAGACAG
TTTATGGAGAAGAAACCCAGCTGGTCTCTGCGGTCACAGGACATTCAGTACAACGGCTCTGAGCTGTCGTGTTTTGACAGACCTCAGCTC
CACGAATATGCCCACAGAGCCTGCTGCCAGTGCCGCCGTGACTCAGTGCAGACCTGCGGGCCGGTGCGCTTGCTCCCATCCATGTGCTGT
GAGGAGGCCTGCAGCCCCAACCCGGCGACTCTTGGTTGTGGGGTGCATTCTGCAGCCAGTCTTCAGGCAAGAAACGCAGGCCCAGCCGGG
GAGATGGTGCCGACTTTCTTCGGATCCCTCACGCAGTCCATCTGTGGCGAGTTTTCAGATGCCTGGCCTCTGATGCAGAATCCCATGGGT
GGTGACAACATCTCTTTTTGTGACTCTTATCCTGAACTCACTGGAGAAGACATTCATTCTCTCAATCCAGAACTTGAAAGCTCAACGTCT
TTGGATTCAAATAGCAGTCAAGATTTGGTTGGTGGGGCTGTTCCAGTCCAGTCTCATTCTGAAAACTTTACAGCAGCTACTGATTTATCT
AGATATAACAACACACTGGTAGAATCAGCATCAACTCAGGATGCACTAACTATGAGAAGCCAGCTAGATCAGGAGAGTGGTGCTGTCATC
CACCCAGCCACTCAGACGTCCCTCCAGGAAGCTTAAAGAACCTGCTTCTTTCTGCAGTAGAAGCGTGTGCTGGAACCCAAAGAGTACTCC
TTTGTTAGGCTTATGGACTGAGCAGTCTGGACCTTGCATGGCTTCTGGGGCAAAAATAAATCTGAACCAAACTGACGGCATTTGAAGCCT
TTCAGCCAGTTGCTTCTGAGCCAGACCAGCTGTAAGCTGAAACCTCAATGAATAACAAGAAAAGACTCCAGGCCGACTCATGATACTCTG
CATCTTTCCTACATGAGAAGCTTCTCTGCCACAAAAGTGACTTCAAAGACGGATGGGTTGAGCTGGCAGCCTATGAGATTGTGGACATAT
AACAAGAAACAGAAATGCCCTCATGCTTATTTTCATGGTGATTGTGGTTTTACAAGACTGAAGACCCAGAGTATACTTTTTCTTTCCAGA
AATAATTTCATACCGCCTATGAAATATCAGATAAATTACCTTAGCTTTTATGTAGAATGGGTTCAAAAGTGAGTGTTTCTATTTGAGAAG
GACACTTTTTCATCATCTAAACTGATTCGCATAGGTGGTTAGAATGGCCCTCATATTGCCTGCCTAAATCTTGGGTTTATTAGATGAAGT
TTACTGAATCAGAGGAATCAGACAGAGGAGGATAGCTCTTTCCAGAATCCACACTTCTGACCTCAGCCTCGGTCTCATGAACACCCGCTG
ATCTCAGGAGAACACCTGGGCTAGGGAATGTGGTCGAGAAAGGGCAGCCCATTGCCCAGAATTAACACATATTGTAGAGACTTGTATGCA
AAGGTTGGCATATTTATATGAAAATTAGTTGCTATAGAAACATTTGTTGCATCTGTCCCTCTGCCTGAGCTTAGAAGGTTATAGAAAAAG
GGTATTTATAAACATAAATGACCTTTTACTTGCATTGTATCTTATACTAAAGGCTTTAGAAATTACAACATATCAGGTTCCCCTACTACT
GAAGTAGCCTTCCGTGAGAACACACCACATGTTAGGACTAGAAGAAAATGCACAATTTGTAGGGGTTTGGATGAAGCAGCTGTAACTGCC
CTAGTGTAGTTTGACCAGGACATTGTCGTGCTCCTTCCAATTGTGTAAGATTAGTTAGCACATCATCTCCTACTTTAGCCATCCGGTGTT
GGATTTAAGAGGACGGTGCTTCTTTCTATTAAAGTGCTCCATCCCCTACCATCTACACATTAGCATTGTCTCTAGAGCTAAGACAGAAAT
TAACCCCGTTCAGTCACAAAGCAGGGAATGGTTCATTTACTCTTAATCTTTATGCCCTGGAGAAGACCTACTTGAACAGGGCATATTTTT
TAGACTTCTGAACATCAGTATGTTCGAGGGTACTATGATATTTTGGTTTGGAATTGCCCTGCCCAAGTCACTGTCTTTTAACTTTTAAAC
TGAATATTAAAATGTATCTGTCTTTCCTAGTATGTTTTTATCTTCTCATGTATTATCCATGGTTTTCTCTGTTTGTGACAGATTAGTAAA
ATTTAATGAGCCCTCTTTCTTGTGGCCGTTTCTCCATAGTTTTAGGTTTTGATATGTGTTTACTAGCTTGCCTGTGTCTGGTACATCTCA
TGACCTCAATTCCCTCACCTGAAATAGGAAATGAGAATGTTTCATTGTAGCCCCAAGCGGTCATGTCAACCTAGTGCCTAGTCATAATTA
ATTGACTTTTCCTGTATTACTTCTTTTTTTAAGTATAAACCAATGATCCTTTGGTAGTCAAGAACTCTTAGGAACATTGCCTTTTGGACA
TGTAAAATATTTAGGATTTGACCACACAATGGCTATGAAAATGCAAGTAGTTTCCTCGCGTGACCTCACCATGATTCACATACGTGCCAC
TGTTTGAAATCTGGTCTGTTTGCATTTCTGTTATGACAGAGAGATGATGTTTGCATTTCTGTTATGACAGAGAGATGATGAAAGTAGGCA
GGGCTGTGTTCCTTTGTGTAGCCTGTATATATTTTCCATATGTAGAGCCCTGATTAACTTCAAGGACAAACACTGGCTGGAGAAAGCCAG
ACTGATGGGAATGAGACTTTGGCCAAAAATCCCAAAACATCATTTTCAATCAGTAGAGAAGTGCTTAGGGTTGAAAATTGATTTCATTTG
CTACTGAATTTGGTAAATCCTGGGTAACTTTTATCAAGATGAAGACATTTTACCCTACCTACTCTAGAAATATACAACAATGTTATATTT
TACACTCCTTGGAAACATTTGAGGAAAAAAATGCAATTTGCACTTCACTTTGTTGGAATATCCCATAGCACTCAATAAACTCAGCTGCTA
GAGTGCCGATGTCAGGAGGGCTGTGTCGGGTAATGCGTGTGGCTGAATGGGCATAACCACTGTGGCTTCTTGTGCTGCAGAAGCTCGTTG
ACAAGACTGAGGAGGATTTCAAGAGCAACCAAGTAAAGTCATGAATTTTCTAATTTTGTGTATATGGAATATATTTTTAAATAGAGATTT
TTCTACTTTAGATAATGTGTTAATATTGCTATTACCTAGGTTAAGCACTATTGTCTGTGCTAGTAAGAAAAAGAAAGGAAAACCATCATT
GCTTTATAGTAGCTTATATCAATTTAGATTTCATCATTACTATTTTGCATACTGGAATTTATAAATGTGTAAATTATCATTTTCTTAGTT

>53749_53749_2_MIPEP-TNFRSF19_MIPEP_chr13_24410379_ENST00000382172_TNFRSF19_chr13_24190006_ENST00000382263_length(amino acids)=938AA_BP=37
MLPWKRGARAPSESSRAGICVGGRDCSGARMLCVGRLGGLGARAAALPPRRAGRGSLEAGIRARRVSTSWSPVGAAFNVKPQGSRLDLFG
ERRGLFGVPELSAPEGFHIAQEKALRKTELLVDRACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVE
KLNTNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLDKEKRKRAVDLNVKILDLSSTFLMGTNFPNKIEKHLLPEHIRR
NFTSAGDHIIIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYSTFSHRALQGTIAKNPETVMQFLEKLSDKLSE
RTLKDFEMIRGMKMKLNPQNSEVMPWDPPYYSGVIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKL
AVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRSSPTLLTPSMMENLFHEMGHAMHSMLGRTRY
QHVTGTRCPTDFAEVPSILMEYFANDYRVVNQFARHYQTGQECGFGYGEDAQCVTCRLHRFKEDWGFQKCKPCLDCAVVNRFQKANCSAT
SDAICGDCLPGFYRKTKLVGFQDMECVPCGDPPPPYEPHCASKVNLVKIASTASSPRDTALAAVICSALATVLLALLILCVIYCKRQFME
KKPSWSLRSQDIQYNGSELSCFDRPQLHEYAHRACCQCRRDSVQTCGPVRLLPSMCCEEACSPNPATLGCGVHSAASLQARNAGPAGEMV
PTFFGSLTQSICGEFSDAWPLMQNPMGGDNISFCDSYPELTGEDIHSLNPELESSTSLDSNSSQDLVGGAVPVQSHSENFTAATDLSRYN

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Fusion Gene PPI Analysis for MIPEP-TNFRSF19

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MIPEP-TNFRSF19

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MIPEP-TNFRSF19

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source