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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APC-DTWD2 (FusionGDB2 ID:5380)

Fusion Gene Summary for APC-DTWD2

check button Fusion gene summary
Fusion gene informationFusion gene name: APC-DTWD2
Fusion gene ID: 5380
HgeneTgene
Gene symbol

APC

DTWD2

Gene ID

5624

285605

Gene nameprotein C, inactivator of coagulation factors Va and VIIIaDTW domain containing 2
SynonymsAPC|PC|PROC1|THPH3|THPH4-
Cytomap

2q14.3

5q23.1

Type of geneprotein-codingprotein-coding
Descriptionvitamin K-dependent protein CProtein C-Nagoyaactivated protein Canticoagulant protein Cautoprothrombin IIAblood coagulation factor XIVprepro-protein Ctype I protein CDTW domain-containing protein 2
Modification date2020031320200313
UniProtAcc

P25054

Q8NBA8

Ensembl transtripts involved in fusion geneENST00000257430, ENST00000457016, 
ENST00000508376, ENST00000505350, 
ENST00000304058, ENST00000510708, 
ENST00000515439, 
Fusion gene scores* DoF score14 X 10 X 8=11209 X 7 X 5=315
# samples 1410
** MAII scorelog2(14/1120*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/315*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APC [Title/Abstract] AND DTWD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPC(112164669)-DTWD2(118183913), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across APC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DTWD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-EQ-A4SO-01AAPCchr5

112164669

+DTWD2chr5

118183913

-
ChimerDB4STADTCGA-EQ-A4SOAPCchr5

112164669

+DTWD2chr5

118183913

-


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Fusion Gene ORF analysis for APC-DTWD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000257430ENST00000304058APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000257430ENST00000510708APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000257430ENST00000515439APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000457016ENST00000304058APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000457016ENST00000510708APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000457016ENST00000515439APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000508376ENST00000304058APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000508376ENST00000510708APCchr5

112164669

+DTWD2chr5

118183913

-
In-frameENST00000508376ENST00000515439APCchr5

112164669

+DTWD2chr5

118183913

-
intron-3CDSENST00000505350ENST00000304058APCchr5

112164669

+DTWD2chr5

118183913

-
intron-3CDSENST00000505350ENST00000510708APCchr5

112164669

+DTWD2chr5

118183913

-
intron-3CDSENST00000505350ENST00000515439APCchr5

112164669

+DTWD2chr5

118183913

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000457016APCchr5112164669+ENST00000304058DTWD2chr5118183913-601821233802422680
ENST00000457016APCchr5112164669+ENST00000510708DTWD2chr5118183913-379921233802422680
ENST00000457016APCchr5112164669+ENST00000515439DTWD2chr5118183913-306121233802422680
ENST00000257430APCchr5112164669+ENST00000304058DTWD2chr5118183913-56941799562098680
ENST00000257430APCchr5112164669+ENST00000510708DTWD2chr5118183913-34751799562098680
ENST00000257430APCchr5112164669+ENST00000515439DTWD2chr5118183913-27371799562098680
ENST00000508376APCchr5112164669+ENST00000304058DTWD2chr5118183913-579519001572199680
ENST00000508376APCchr5112164669+ENST00000510708DTWD2chr5118183913-357619001572199680
ENST00000508376APCchr5112164669+ENST00000515439DTWD2chr5118183913-283819001572199680

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000457016ENST00000304058APCchr5112164669+DTWD2chr5118183913-0.0003167560.99968326
ENST00000457016ENST00000510708APCchr5112164669+DTWD2chr5118183913-0.0007861540.9992138
ENST00000457016ENST00000515439APCchr5112164669+DTWD2chr5118183913-0.0020606640.9979393
ENST00000257430ENST00000304058APCchr5112164669+DTWD2chr5118183913-0.0002851150.9997149
ENST00000257430ENST00000510708APCchr5112164669+DTWD2chr5118183913-0.0006010480.99939895
ENST00000257430ENST00000515439APCchr5112164669+DTWD2chr5118183913-0.0013914670.9986085
ENST00000508376ENST00000304058APCchr5112164669+DTWD2chr5118183913-0.0003027920.9996972
ENST00000508376ENST00000510708APCchr5112164669+DTWD2chr5118183913-0.0006589580.9993411
ENST00000508376ENST00000515439APCchr5112164669+DTWD2chr5118183913-0.0015431820.99845684

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Fusion Genomic Features for APC-DTWD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for APC-DTWD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:112164669/chr5:118183913)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APC

P25054

DTWD2

Q8NBA8

FUNCTION: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.FUNCTION: Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)) (PubMed:31804502). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)) (PubMed:31804502). {ECO:0000269|PubMed:31804502}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416127_2485812844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+14162_615812844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416127_2485812844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+14162_615812844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517127_2485812844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+15172_615812844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416453_4955812844.0RepeatNote=ARM 1
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416505_5475812844.0RepeatNote=ARM 2
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416453_4955812844.0RepeatNote=ARM 1
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416505_5475812844.0RepeatNote=ARM 2
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517453_4955812844.0RepeatNote=ARM 1
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517505_5475812844.0RepeatNote=ARM 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+14161131_11565812844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+14161558_15775812844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+14161_7305812844.0Compositional biasNote=Leu-rich
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416731_28325812844.0Compositional biasNote=Ser-rich
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+14161131_11565812844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+14161558_15775812844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+14161_7305812844.0Compositional biasNote=Leu-rich
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416731_28325812844.0Compositional biasNote=Ser-rich
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+15171131_11565812844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+15171558_15775812844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+15171_7305812844.0Compositional biasNote=Leu-rich
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517731_28325812844.0Compositional biasNote=Ser-rich
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+14162803_28065812844.0MotifNote=Microtubule tip localization signal
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+14162841_28435812844.0MotifNote=PDZ-binding
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+14162803_28065812844.0MotifNote=Microtubule tip localization signal
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+14162841_28435812844.0MotifNote=PDZ-binding
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+15172803_28065812844.0MotifNote=Microtubule tip localization signal
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+15172841_28435812844.0MotifNote=PDZ-binding
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+14161866_18935812844.0RegionNote=Highly charged
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416960_13375812844.0RegionNote=Responsible for down-regulation through a process mediated by direct ubiquitination
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+14161866_18935812844.0RegionNote=Highly charged
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416960_13375812844.0RegionNote=Responsible for down-regulation through a process mediated by direct ubiquitination
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+15171866_18935812844.0RegionNote=Highly charged
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517960_13375812844.0RegionNote=Responsible for down-regulation through a process mediated by direct ubiquitination
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416548_5915812844.0RepeatNote=ARM 3
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416592_6385812844.0RepeatNote=ARM 4
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416639_6835812844.0RepeatNote=ARM 5
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416684_7255812844.0RepeatNote=ARM 6
HgeneAPCchr5:112164669chr5:118183913ENST00000257430+1416726_7675812844.0RepeatNote=ARM 7
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416548_5915812844.0RepeatNote=ARM 3
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416592_6385812844.0RepeatNote=ARM 4
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416639_6835812844.0RepeatNote=ARM 5
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416684_7255812844.0RepeatNote=ARM 6
HgeneAPCchr5:112164669chr5:118183913ENST00000457016+1416726_7675812844.0RepeatNote=ARM 7
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517548_5915812844.0RepeatNote=ARM 3
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517592_6385812844.0RepeatNote=ARM 4
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517639_6835812844.0RepeatNote=ARM 5
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517684_7255812844.0RepeatNote=ARM 6
HgeneAPCchr5:112164669chr5:118183913ENST00000508376+1517726_7675812844.0RepeatNote=ARM 7
TgeneDTWD2chr5:112164669chr5:118183913ENST0000051070836178_181199299.0MotifNote=DXTW


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Fusion Gene Sequence for APC-DTWD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5380_5380_1_APC-DTWD2_APC_chr5_112164669_ENST00000257430_DTWD2_chr5_118183913_ENST00000304058_length(transcript)=5694nt_BP=1799nt
GGAGACAGAATGGAGGTGCTGCCGGACTCGGAAATGGGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGC
AAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCAT
CTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTC
TTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGAT
CTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTG
GATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAAC
TTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATG
AAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTC
AGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAA
CCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTA
CACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGG
TGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAG
ACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAA
ATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGC
GTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGG
ACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGC
ATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACC
ACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTA
TGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGT
CTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGG
TGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTG
CTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTG
CCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGG
AATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTT
CATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATT
CATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATG
TTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATT
GGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTA
CAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGT
ATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGA
AATAGCACACATTTTCATTTGTAATCACTCTGGATAAATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCTGGTAAACTTAT
TTTATTGATGTTTTCATATGGAAAATAATAAGTGGAATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCTATTTAATATAA
CCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAAAAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTGTATAGAATAAG
AGACATGTATGTAACATATATGTATATTCAGCACAAGTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATTTTGTTTAGTCT
TTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGTTAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACTTGGTAACTATT
TATAGAGCATACACCAATGATTATTTCTCACAGTTTTCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAAAAGGTATAATG
CTGGTCACAATTAGAATGCTAATATTTGGGGAAACTATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTATTGTTGATTTA
TTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCATTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGTGAGAATTGCTT
GAGCCCAGGAGTTTGAGACCAGCCTGGGCAATATGGTGAGACTCCATCTCCATACAAAATTAAAAAAAAAATAATTAGCCAGATGTGGTG
GTGTGCACTTGTAGTCCTAGCTACTTGGGAGGCTAAGGTGGGAGGATCGCTGGAGCCCAGGACATCAAGGTTGCAAGGAGCTATGTTCAT
TCCACTGCACTCCAGCCTGGGCTACAGAGTGAGACCTGTCTAAAATAAATAAATAAATAAACAAACTAGCTCATTTACAATGTAAAGCAC
TTAATATCAAATGATTATTTGGTGTACTAGAAAAGAAACAGCATATAATAATGTATAATAGTTTCTTAACAAGTGGGGCTAAAATCATTT
TGTAGTAATTTTTCACATTGATATTAAACTTCATGAGTTTCTTTTAGTCATTATTATTATTATTATTATTATTTGAGATGGAATCTCGCT
CTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTTGGCTCACTGAAAGCTCTGCCTCCTGGGTTCACGCCATTCTTCTGCCTCAGCCTCC
TGAGTAGCTGGGACTACAGGTGCCCACCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTATTAGCCAGGA
TGGTCTCGATCTCCTGACCTCGTGATCTGTCTGCCTTGGCCTCCAAAAGTGCTGGGACCGTGCCCAGCCATCATTATTATTTTTTAAAAA
GAAAACTCCCCCTACCCCCAGTATACCATTTTGTATCTCAAAATTTTACTTTATTGATTTTTAAGAGTAATTTCTACTTTTATCTTTTAA
ATAAAACATTTTAGAGTATTTTTGAAGACTTAAAAAGCTTAAAATTTAGTGTTTTTGGAAATGTATAAAATTTTCTTGAAGTATGTATAG
TTTTCCAAATTACTTTACTGACCTGTTAACTCACTGTACTTGTTTTTTACTTATTTTTTCCTGACCTCTTAACAAGGTGAGTCCATTTAA
TCATCTGTGGTATAAAATGCTTCTCTAGTCACCTGTTCTCATTAAACAGTTGTAAGTAAGTTTTAAAAGCCATTATTTTAATTACTAAAA
GTTCTCAAGTGTGTAGTATTATCTGAGTATTTTAATTGAAAAATTAATCAGGCTTTTAAAAATTACTTTTTTATTGTATTAGTTGGCTTT
TAAATTCAGATTCTTTATATTTGCTTGATTTTTCCTGGAAGTTCCAAGTTTTATGAATTTGTAGCTGATAGTAGGTTTTACTTGTGTACC
CCATCTGCACTTTGATGTTGTGTAGATCGTTTTGTGAGTTATTTGAACCGTGTAACTCAGAGAATAGTATTTCCTCATACATAAAGTGAC
CTCACTTTTAATCAGCTCCTTTATAGTATGTTGAAAATCACTGCGTGTAATGAGAGGTATTGAGAGTTTCTTGCACACATGAGTGTAAAA
GGTTGAGAACTAGATTATACAAAGTAGTAAGTCACAGTGCATGGCAACTTTCTACAGGTTGGATTATAAGACTTATGTGGAATAGGAGAA
TTATATTGGGAAAAAATTATTTTCTCTAACTTGAAGACTCCAGAGACACTTTTCTTAGTCATGACCAGTAATATTTTTCATATATTTTGG
AAGAAATAAGCTCCTCACTATACCACCAGTTAGTGATTTATTTATTTATGTATTTTAGAGACAGGGCCTCCTTCTGTCACCCAGTTTGGA
GTGCAGTGGTGTAATCATAGCTTACTGCAGCATCAAACTCCTGGGCTCAAGTGTTCCTCCTGCCTCAGCCTCCCAAGTAGCTAGAACCTC
AGCCCCATGCCACCACACTCAGCTAATTTTAAATTTTACTAATTTCATTTAATTTTTGTGGAGATGGGGGTCTTGCTGTGTTGTTTAGGC
TGGTCCTGAACTCCTGGCCTCAAGCGATCCTTCTGCCTTGGCCTCTCAGTAAATTATATAGAAGAGCACTTCTGTATAATTTACTCAGTT
TCTTCATCACATATTTCCAACTGTTGCCCTAAATAGGTTTAAAAATGTGATCATGTTATTAGAAAATCCTTTCCATTGAATTTCAGGGAT
GCTGAATTTCAGGGAGCTAAATTGTTGACCCTTGCCTGTAGTTGTTATTGGTTCAGAAGTAAATTTTATTGATGCTACAAGTAAAAAATT
AGATCTGACTTAGTAAACTCAAAAGTTTTACAAAACTGTATTTTACTATGTAGATGTATTTCTTTAAAATAGGTATGGATGGATATTTTT

>5380_5380_1_APC-DTWD2_APC_chr5_112164669_ENST00000257430_DTWD2_chr5_118183913_ENST00000304058_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

--------------------------------------------------------------
>5380_5380_2_APC-DTWD2_APC_chr5_112164669_ENST00000257430_DTWD2_chr5_118183913_ENST00000510708_length(transcript)=3475nt_BP=1799nt
GGAGACAGAATGGAGGTGCTGCCGGACTCGGAAATGGGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGC
AAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCAT
CTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTC
TTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGAT
CTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTG
GATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAAC
TTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATG
AAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTC
AGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAA
CCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTA
CACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGG
TGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAG
ACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAA
ATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGC
GTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGG
ACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGC
ATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACC
ACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTA
TGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGT
CTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGG
TGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTG
CTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTG
CCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGG
AATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTT
CATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATT
CATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATG
TTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATT
GGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTA
CAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGT
ATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGA
AATAGCACACATTTTCATTTGTAATCACTCTGGATAAATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCTGGTAAACTTAT
TTTATTGATGTTTTCATATGGAAAATAATAAGTGGAATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCTATTTAATATAA
CCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAAAAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTGTATAGAATAAG
AGACATGTATGTAACATATATGTATATTCAGCACAAGTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATTTTGTTTAGTCT
TTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGTTAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACTTGGTAACTATT
TATAGAGCATACACCAATGATTATTTCTCACAGTTTTCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAAAAGGTATAATG
CTGGTCACAATTAGAATGCTAATATTTGGGGAAACTATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTATTGTTGATTTA
TTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCATTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGTGAGAATTGCTT

>5380_5380_2_APC-DTWD2_APC_chr5_112164669_ENST00000257430_DTWD2_chr5_118183913_ENST00000510708_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

--------------------------------------------------------------
>5380_5380_3_APC-DTWD2_APC_chr5_112164669_ENST00000257430_DTWD2_chr5_118183913_ENST00000515439_length(transcript)=2737nt_BP=1799nt
GGAGACAGAATGGAGGTGCTGCCGGACTCGGAAATGGGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGC
AAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCAT
CTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTC
TTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGAT
CTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTG
GATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAAC
TTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATG
AAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTC
AGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAA
CCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTA
CACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGG
TGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAG
ACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAA
ATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGC
GTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGG
ACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGC
ATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACC
ACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTA
TGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGT
CTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGG
TGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTG
CTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTG
CCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGG
AATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTT
CATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATT
CATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATG
TTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATT
GGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTA
CAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGT
ATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGA

>5380_5380_3_APC-DTWD2_APC_chr5_112164669_ENST00000257430_DTWD2_chr5_118183913_ENST00000515439_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

--------------------------------------------------------------
>5380_5380_4_APC-DTWD2_APC_chr5_112164669_ENST00000457016_DTWD2_chr5_118183913_ENST00000304058_length(transcript)=6018nt_BP=2123nt
ACAAGATGGCGGAGGGCAAGTAGCAAGGGGGCGGGGTGTGGCCGCCGGAAGCCTAGCCGCTGCTCGGGGGGGACCTGCGGGCTCAGGCCC
GGGAGCTGCGGACCGAGGTTGGCTCGATGCTGTTCCCAGGTACTGTTGTTGGCTGTTGGTGAGGAAGGTGAAGCACTCAGTTGCCTTCTC
GGGCCTCGGCGCCCCCTATGTACGCCTCCCTGGGCTCGGGTCCGGTCGCCCCTTTGCCCGCTTCTGTACCACCCTCAGTTCTCGGGTCCT
GGAGCACCGGCGGCAGCAGGAGCTGCGTCCGGCAGGAGACGAAGAGCCCGGGCGGCGCTCGTACTTCTGGCCACTGGGCGAGCGTCTGGC
AGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTC
GACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAA
GTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTG
GAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTC
CTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGC
TTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTT
TAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAAC
TAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGC
TTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTC
AAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTT
CTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTA
CTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTC
CTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCA
GTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATAC
GCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAAC
ATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGG
CCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGG
CTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAA
AATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGC
GAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAA
TTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAG
AGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAA
ATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTT
ATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAA
AGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACT
GAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTG
TGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAAT
TAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAA
TCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATG
ATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGAAATAGCACACATTTTCATTTGTAATCACTCTGGATA
AATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCTGGTAAACTTATTTTATTGATGTTTTCATATGGAAAATAATAAGTGGA
ATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCTATTTAATATAACCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAA
AAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTGTATAGAATAAGAGACATGTATGTAACATATATGTATATTCAGCACAA
GTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATTTTGTTTAGTCTTTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGT
TAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACTTGGTAACTATTTATAGAGCATACACCAATGATTATTTCTCACAGTTT
TCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAAAAGGTATAATGCTGGTCACAATTAGAATGCTAATATTTGGGGAAACT
ATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTATTGTTGATTTATTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCAT
TAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGTGAGAATTGCTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAATATGG
TGAGACTCCATCTCCATACAAAATTAAAAAAAAAATAATTAGCCAGATGTGGTGGTGTGCACTTGTAGTCCTAGCTACTTGGGAGGCTAA
GGTGGGAGGATCGCTGGAGCCCAGGACATCAAGGTTGCAAGGAGCTATGTTCATTCCACTGCACTCCAGCCTGGGCTACAGAGTGAGACC
TGTCTAAAATAAATAAATAAATAAACAAACTAGCTCATTTACAATGTAAAGCACTTAATATCAAATGATTATTTGGTGTACTAGAAAAGA
AACAGCATATAATAATGTATAATAGTTTCTTAACAAGTGGGGCTAAAATCATTTTGTAGTAATTTTTCACATTGATATTAAACTTCATGA
GTTTCTTTTAGTCATTATTATTATTATTATTATTATTTGAGATGGAATCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTTG
GCTCACTGAAAGCTCTGCCTCCTGGGTTCACGCCATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCACCACCACGCC
CGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTATTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGTCTGCCT
TGGCCTCCAAAAGTGCTGGGACCGTGCCCAGCCATCATTATTATTTTTTAAAAAGAAAACTCCCCCTACCCCCAGTATACCATTTTGTAT
CTCAAAATTTTACTTTATTGATTTTTAAGAGTAATTTCTACTTTTATCTTTTAAATAAAACATTTTAGAGTATTTTTGAAGACTTAAAAA
GCTTAAAATTTAGTGTTTTTGGAAATGTATAAAATTTTCTTGAAGTATGTATAGTTTTCCAAATTACTTTACTGACCTGTTAACTCACTG
TACTTGTTTTTTACTTATTTTTTCCTGACCTCTTAACAAGGTGAGTCCATTTAATCATCTGTGGTATAAAATGCTTCTCTAGTCACCTGT
TCTCATTAAACAGTTGTAAGTAAGTTTTAAAAGCCATTATTTTAATTACTAAAAGTTCTCAAGTGTGTAGTATTATCTGAGTATTTTAAT
TGAAAAATTAATCAGGCTTTTAAAAATTACTTTTTTATTGTATTAGTTGGCTTTTAAATTCAGATTCTTTATATTTGCTTGATTTTTCCT
GGAAGTTCCAAGTTTTATGAATTTGTAGCTGATAGTAGGTTTTACTTGTGTACCCCATCTGCACTTTGATGTTGTGTAGATCGTTTTGTG
AGTTATTTGAACCGTGTAACTCAGAGAATAGTATTTCCTCATACATAAAGTGACCTCACTTTTAATCAGCTCCTTTATAGTATGTTGAAA
ATCACTGCGTGTAATGAGAGGTATTGAGAGTTTCTTGCACACATGAGTGTAAAAGGTTGAGAACTAGATTATACAAAGTAGTAAGTCACA
GTGCATGGCAACTTTCTACAGGTTGGATTATAAGACTTATGTGGAATAGGAGAATTATATTGGGAAAAAATTATTTTCTCTAACTTGAAG
ACTCCAGAGACACTTTTCTTAGTCATGACCAGTAATATTTTTCATATATTTTGGAAGAAATAAGCTCCTCACTATACCACCAGTTAGTGA
TTTATTTATTTATGTATTTTAGAGACAGGGCCTCCTTCTGTCACCCAGTTTGGAGTGCAGTGGTGTAATCATAGCTTACTGCAGCATCAA
ACTCCTGGGCTCAAGTGTTCCTCCTGCCTCAGCCTCCCAAGTAGCTAGAACCTCAGCCCCATGCCACCACACTCAGCTAATTTTAAATTT
TACTAATTTCATTTAATTTTTGTGGAGATGGGGGTCTTGCTGTGTTGTTTAGGCTGGTCCTGAACTCCTGGCCTCAAGCGATCCTTCTGC
CTTGGCCTCTCAGTAAATTATATAGAAGAGCACTTCTGTATAATTTACTCAGTTTCTTCATCACATATTTCCAACTGTTGCCCTAAATAG
GTTTAAAAATGTGATCATGTTATTAGAAAATCCTTTCCATTGAATTTCAGGGATGCTGAATTTCAGGGAGCTAAATTGTTGACCCTTGCC
TGTAGTTGTTATTGGTTCAGAAGTAAATTTTATTGATGCTACAAGTAAAAAATTAGATCTGACTTAGTAAACTCAAAAGTTTTACAAAAC

>5380_5380_4_APC-DTWD2_APC_chr5_112164669_ENST00000457016_DTWD2_chr5_118183913_ENST00000304058_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

--------------------------------------------------------------
>5380_5380_5_APC-DTWD2_APC_chr5_112164669_ENST00000457016_DTWD2_chr5_118183913_ENST00000510708_length(transcript)=3799nt_BP=2123nt
ACAAGATGGCGGAGGGCAAGTAGCAAGGGGGCGGGGTGTGGCCGCCGGAAGCCTAGCCGCTGCTCGGGGGGGACCTGCGGGCTCAGGCCC
GGGAGCTGCGGACCGAGGTTGGCTCGATGCTGTTCCCAGGTACTGTTGTTGGCTGTTGGTGAGGAAGGTGAAGCACTCAGTTGCCTTCTC
GGGCCTCGGCGCCCCCTATGTACGCCTCCCTGGGCTCGGGTCCGGTCGCCCCTTTGCCCGCTTCTGTACCACCCTCAGTTCTCGGGTCCT
GGAGCACCGGCGGCAGCAGGAGCTGCGTCCGGCAGGAGACGAAGAGCCCGGGCGGCGCTCGTACTTCTGGCCACTGGGCGAGCGTCTGGC
AGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTC
GACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAA
GTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTG
GAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTC
CTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGC
TTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTT
TAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAAC
TAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGC
TTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTC
AAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTT
CTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTA
CTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTC
CTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCA
GTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATAC
GCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAAC
ATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGG
CCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGG
CTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAA
AATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGC
GAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAA
TTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAG
AGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAA
ATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTT
ATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAA
AGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACT
GAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTG
TGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAAT
TAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAA
TCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATG
ATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGAAATAGCACACATTTTCATTTGTAATCACTCTGGATA
AATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCTGGTAAACTTATTTTATTGATGTTTTCATATGGAAAATAATAAGTGGA
ATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCTATTTAATATAACCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAA
AAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTGTATAGAATAAGAGACATGTATGTAACATATATGTATATTCAGCACAA
GTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATTTTGTTTAGTCTTTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGT
TAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACTTGGTAACTATTTATAGAGCATACACCAATGATTATTTCTCACAGTTT
TCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAAAAGGTATAATGCTGGTCACAATTAGAATGCTAATATTTGGGGAAACT
ATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTATTGTTGATTTATTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCAT
TAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGTGAGAATTGCTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAATATGG

>5380_5380_5_APC-DTWD2_APC_chr5_112164669_ENST00000457016_DTWD2_chr5_118183913_ENST00000510708_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

--------------------------------------------------------------
>5380_5380_6_APC-DTWD2_APC_chr5_112164669_ENST00000457016_DTWD2_chr5_118183913_ENST00000515439_length(transcript)=3061nt_BP=2123nt
ACAAGATGGCGGAGGGCAAGTAGCAAGGGGGCGGGGTGTGGCCGCCGGAAGCCTAGCCGCTGCTCGGGGGGGACCTGCGGGCTCAGGCCC
GGGAGCTGCGGACCGAGGTTGGCTCGATGCTGTTCCCAGGTACTGTTGTTGGCTGTTGGTGAGGAAGGTGAAGCACTCAGTTGCCTTCTC
GGGCCTCGGCGCCCCCTATGTACGCCTCCCTGGGCTCGGGTCCGGTCGCCCCTTTGCCCGCTTCTGTACCACCCTCAGTTCTCGGGTCCT
GGAGCACCGGCGGCAGCAGGAGCTGCGTCCGGCAGGAGACGAAGAGCCCGGGCGGCGCTCGTACTTCTGGCCACTGGGCGAGCGTCTGGC
AGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTC
GACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAA
GTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTG
GAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTC
CTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGC
TTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTT
TAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAAC
TAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGC
TTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAACAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTC
AAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCAGGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTT
CTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCTGGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTA
CTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTCTAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTC
CTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGTATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCA
GTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAAGAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATAC
GCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGAACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAAC
ATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATTTGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGG
CCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCTTACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGG
CTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTACGCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAA
AATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTTGAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGC
GAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGAAGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAA
TTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTGTGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAG
AGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACTTCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAA
ATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACTCAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTT
ATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCAAATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAA
AGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTAAACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACT
GAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCCTCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTG
TGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGTTGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAAT
TAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAGTCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAA
TCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGGAAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATG
ATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCATGTAATTTTGAAATAGCACACATTTTCATTTGTAATCACTCTGGATA

>5380_5380_6_APC-DTWD2_APC_chr5_112164669_ENST00000457016_DTWD2_chr5_118183913_ENST00000515439_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

--------------------------------------------------------------
>5380_5380_7_APC-DTWD2_APC_chr5_112164669_ENST00000508376_DTWD2_chr5_118183913_ENST00000304058_length(transcript)=5795nt_BP=1900nt
GAATGGAGGTGCTGCCGGACTCGGAAATGGGGACACATGCATTGGTGGCCAAAAGAGAGAGGAGACAAAACCGCTGCAGATGGCTGATGT
GAATCTAGTGGAAAGAGCTACTGGGGATGAGAGAAAGAGGAGGAGGCAGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCA
GTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGA
AACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTT
ATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAG
CCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAG
AGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTA
TTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCA
ATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAAT
AGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAA
CAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCA
GGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCT
GGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTC
TAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGT
ATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAA
GAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGA
ACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATT
TGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCT
TACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTAC
GCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTT
GAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGA
AGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTG
TGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACT
TCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACT
CAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCA
AATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTA
AACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCC
TCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGT
TGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAG
TCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGG
AAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCA
TGTAATTTTGAAATAGCACACATTTTCATTTGTAATCACTCTGGATAAATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCT
GGTAAACTTATTTTATTGATGTTTTCATATGGAAAATAATAAGTGGAATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCT
ATTTAATATAACCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAAAAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTG
TATAGAATAAGAGACATGTATGTAACATATATGTATATTCAGCACAAGTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATT
TTGTTTAGTCTTTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGTTAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACT
TGGTAACTATTTATAGAGCATACACCAATGATTATTTCTCACAGTTTTCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAA
AAGGTATAATGCTGGTCACAATTAGAATGCTAATATTTGGGGAAACTATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTA
TTGTTGATTTATTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCATTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGT
GAGAATTGCTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAATATGGTGAGACTCCATCTCCATACAAAATTAAAAAAAAAATAATTAGC
CAGATGTGGTGGTGTGCACTTGTAGTCCTAGCTACTTGGGAGGCTAAGGTGGGAGGATCGCTGGAGCCCAGGACATCAAGGTTGCAAGGA
GCTATGTTCATTCCACTGCACTCCAGCCTGGGCTACAGAGTGAGACCTGTCTAAAATAAATAAATAAATAAACAAACTAGCTCATTTACA
ATGTAAAGCACTTAATATCAAATGATTATTTGGTGTACTAGAAAAGAAACAGCATATAATAATGTATAATAGTTTCTTAACAAGTGGGGC
TAAAATCATTTTGTAGTAATTTTTCACATTGATATTAAACTTCATGAGTTTCTTTTAGTCATTATTATTATTATTATTATTATTTGAGAT
GGAATCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTTGGCTCACTGAAAGCTCTGCCTCCTGGGTTCACGCCATTCTTCTG
CCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCACCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGT
ATTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCTGTCTGCCTTGGCCTCCAAAAGTGCTGGGACCGTGCCCAGCCATCATTATTA
TTTTTTAAAAAGAAAACTCCCCCTACCCCCAGTATACCATTTTGTATCTCAAAATTTTACTTTATTGATTTTTAAGAGTAATTTCTACTT
TTATCTTTTAAATAAAACATTTTAGAGTATTTTTGAAGACTTAAAAAGCTTAAAATTTAGTGTTTTTGGAAATGTATAAAATTTTCTTGA
AGTATGTATAGTTTTCCAAATTACTTTACTGACCTGTTAACTCACTGTACTTGTTTTTTACTTATTTTTTCCTGACCTCTTAACAAGGTG
AGTCCATTTAATCATCTGTGGTATAAAATGCTTCTCTAGTCACCTGTTCTCATTAAACAGTTGTAAGTAAGTTTTAAAAGCCATTATTTT
AATTACTAAAAGTTCTCAAGTGTGTAGTATTATCTGAGTATTTTAATTGAAAAATTAATCAGGCTTTTAAAAATTACTTTTTTATTGTAT
TAGTTGGCTTTTAAATTCAGATTCTTTATATTTGCTTGATTTTTCCTGGAAGTTCCAAGTTTTATGAATTTGTAGCTGATAGTAGGTTTT
ACTTGTGTACCCCATCTGCACTTTGATGTTGTGTAGATCGTTTTGTGAGTTATTTGAACCGTGTAACTCAGAGAATAGTATTTCCTCATA
CATAAAGTGACCTCACTTTTAATCAGCTCCTTTATAGTATGTTGAAAATCACTGCGTGTAATGAGAGGTATTGAGAGTTTCTTGCACACA
TGAGTGTAAAAGGTTGAGAACTAGATTATACAAAGTAGTAAGTCACAGTGCATGGCAACTTTCTACAGGTTGGATTATAAGACTTATGTG
GAATAGGAGAATTATATTGGGAAAAAATTATTTTCTCTAACTTGAAGACTCCAGAGACACTTTTCTTAGTCATGACCAGTAATATTTTTC
ATATATTTTGGAAGAAATAAGCTCCTCACTATACCACCAGTTAGTGATTTATTTATTTATGTATTTTAGAGACAGGGCCTCCTTCTGTCA
CCCAGTTTGGAGTGCAGTGGTGTAATCATAGCTTACTGCAGCATCAAACTCCTGGGCTCAAGTGTTCCTCCTGCCTCAGCCTCCCAAGTA
GCTAGAACCTCAGCCCCATGCCACCACACTCAGCTAATTTTAAATTTTACTAATTTCATTTAATTTTTGTGGAGATGGGGGTCTTGCTGT
GTTGTTTAGGCTGGTCCTGAACTCCTGGCCTCAAGCGATCCTTCTGCCTTGGCCTCTCAGTAAATTATATAGAAGAGCACTTCTGTATAA
TTTACTCAGTTTCTTCATCACATATTTCCAACTGTTGCCCTAAATAGGTTTAAAAATGTGATCATGTTATTAGAAAATCCTTTCCATTGA
ATTTCAGGGATGCTGAATTTCAGGGAGCTAAATTGTTGACCCTTGCCTGTAGTTGTTATTGGTTCAGAAGTAAATTTTATTGATGCTACA
AGTAAAAAATTAGATCTGACTTAGTAAACTCAAAAGTTTTACAAAACTGTATTTTACTATGTAGATGTATTTCTTTAAAATAGGTATGGA

>5380_5380_7_APC-DTWD2_APC_chr5_112164669_ENST00000508376_DTWD2_chr5_118183913_ENST00000304058_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

--------------------------------------------------------------
>5380_5380_8_APC-DTWD2_APC_chr5_112164669_ENST00000508376_DTWD2_chr5_118183913_ENST00000510708_length(transcript)=3576nt_BP=1900nt
GAATGGAGGTGCTGCCGGACTCGGAAATGGGGACACATGCATTGGTGGCCAAAAGAGAGAGGAGACAAAACCGCTGCAGATGGCTGATGT
GAATCTAGTGGAAAGAGCTACTGGGGATGAGAGAAAGAGGAGGAGGCAGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCA
GTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGA
AACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTT
ATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAG
CCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAG
AGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTA
TTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCA
ATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAAT
AGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAA
CAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCA
GGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCT
GGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTC
TAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGT
ATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAA
GAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGA
ACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATT
TGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCT
TACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTAC
GCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTT
GAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGA
AGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTG
TGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACT
TCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACT
CAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCA
AATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTA
AACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCC
TCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGT
TGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAG
TCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGG
AAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCA
TGTAATTTTGAAATAGCACACATTTTCATTTGTAATCACTCTGGATAAATTTGTATTTTTCAGTGTTCATTGAACAGGCTTATTGACTCT
GGTAAACTTATTTTATTGATGTTTTCATATGGAAAATAATAAGTGGAATATGATACAATTGTTATTTTCAGAACATATTTCTTTAGGGCT
ATTTAATATAACCTTTTTAACGAGCAAAAACTTTCCATTTGAGAGAAAAAATTCTTCCTGCTCTGTGGGAAAATATTTGCTGAGATTTTG
TATAGAATAAGAGACATGTATGTAACATATATGTATATTCAGCACAAGTCTACTGCAATTATGTACACATTTTGGCAGGAAGAGGGGATT
TTGTTTAGTCTTTGTTTATGAGTTCTAGAGTTTCCTGTATCTAGTGTTAAGTTGTAAGGAAAAACTAAACATGCCATTTAAAGGTAAACT
TGGTAACTATTTATAGAGCATACACCAATGATTATTTCTCACAGTTTTCATGATCATTTGTTTATTATTTACTTGGATTAGACTCATTAA
AAGGTATAATGCTGGTCACAATTAGAATGCTAATATTTGGGGAAACTATGCAGAAAATATTTTAAAATATTAAAAGAGTGCTGGCTTCTA
TTGTTGATTTATTTTTGGATTTAAAAACAAATTAGGGCTGGGCCCATTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGATGT

>5380_5380_8_APC-DTWD2_APC_chr5_112164669_ENST00000508376_DTWD2_chr5_118183913_ENST00000510708_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

--------------------------------------------------------------
>5380_5380_9_APC-DTWD2_APC_chr5_112164669_ENST00000508376_DTWD2_chr5_118183913_ENST00000515439_length(transcript)=2838nt_BP=1900nt
GAATGGAGGTGCTGCCGGACTCGGAAATGGGGACACATGCATTGGTGGCCAAAAGAGAGAGGAGACAAAACCGCTGCAGATGGCTGATGT
GAATCTAGTGGAAAGAGCTACTGGGGATGAGAGAAAGAGGAGGAGGCAGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCA
GTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGA
AACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTT
ATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAG
CCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAG
AGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTA
TTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCA
ATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAAT
AGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGAGGTCATCTCAGAA
CAAGCATGAAACCGGCTCACATGATGCTGAGCGGCAGAATGAAGGTCAAGGAGTGGGAGAAATCAACATGGCAACTTCTGGTAATGGTCA
GGGTTCAACTACACGAATGGACCATGAAACAGCCAGTGTTTTGAGTTCTAGTAGCACACACTCTGCACCTCGAAGGCTGACAAGTCATCT
GGGAACCAAGGTGGAAATGGTGTATTCATTGTTGTCAATGCTTGGTACTCATGATAAGGATGATATGTCGCGAACTTTGCTAGCTATGTC
TAGCTCCCAAGACAGCTGTATATCCATGCGACAGTCTGGATGTCTTCCTCTCCTCATCCAGCTTTTACATGGCAATGACAAAGACTCTGT
ATTGTTGGGAAATTCCCGGGGCAGTAAAGAGGCTCGGGCCAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACAA
GAGAGGCAGGCGTGAAATCCGAGTCCTTCATCTTTTGGAACAGATACGCGCTTACTGTGAAACCTGTTGGGAGTGGCAGGAAGCTCATGA
ACCAGGCATGGACCAGGACAAAAATCCAATGCCAGCTCCTGTTGAACATCAGATCTGTCCTGCTGTGTGTGTTCTAATGAAACTTTCATT
TGATGAAGAGCATAGACATGCAATGAATGAACTAGGGGGACTACAGGCCATTGCAGAATTATTGCAAGTGGACTGTGAAATGTATGGGCT
TACTAATGACCACTACAGTATTACACTAAGACGATATGCTGGAATGGCTTTGACAAACTTGACTTTTGGAGATGTAGCCAACAAGGCTAC
GCTATGCTCTATGAAAGGCTGCATGAGAGCACTTGTGGCCCAACTAAAATCTGAAAGTGAAGACTTACAGCAGGTTATTGCGAGTGTTTT
GAGGAATTTGTCTTGGCGAGCAGATGTAAATAGTAAAAAGACGTTGCGAGAAGTTGGAAGTGTGAAAGCATTGATGGAATGTGCTTTAGA
AGTTAAAAAGGTGCAATTAAAAACTAGCATTTCTAGTCAGTATGTAATTCGGATGCAGCCGACTAATAGATGCCTTTCTACACTGGAGTG
TGCAGCTGTTGCTCTTTCCATCTTGGAGAAAAATAATTACATACAAGAGACTTTGCTTCGCCCTCTTCAAGCTTTATGCTCCTTTCAACT
TCAGCATGGTGCCCAAATTCGCCTCAGCAAGGAACACCTTCTGAAAAATGGATTATATCCTAAACCAATGCCAAAGAACAAACGCAAACT
CAGGAAAATGGAATTGTTAATGAATAGTGTTAAAATTTAGTACAGTTATTCTTTTGGTGCTAGCTTAACTGTCTTCATCTAACAATACCA
AATTAAGTTTTCATATAGTTAAGGTCTGTAGGTTTTTGACTTGCTAAAGAAGGAGAATTGCATACTAATCTTACCCAGAAGAAGGAAGTA
AACCAAATATTCATAAATACAAATAAACAGAAATTCACTGGCTCACTGAAAAGCAGGATTTCCTACTGTACTTGTTTTTAAAAATGTGCC
TCTAATACATGTTTTCAAACCCAAATTTAAAATATGATTTGTTGTTGTGATAGGTTAGAAGTTCTTACTTGTAAAATAGAAGAAAATTGT
TGTAGTGGATTGGAACGGTGTTGTGTCCATTAATGTTTATAAATAATTAGGTGTAGACCAATAATATAAGATTCCTACATCAGTTTGCAG
TCCTGACTTTACAGTTTGAAATAAGTAGCAAAAGAAAATTATGATAATCAAGTAATTTATTATTTTGTAAAATAGTATAAAGGAATAAGG
AAATTTTAAGTATTGTTTAGGGGCCAAATTTGAACTCAGCTAATATGATTTAAGCGCTCTATTAATTGCCCTGATTTTTAAAGAGGTGCA

>5380_5380_9_APC-DTWD2_APC_chr5_112164669_ENST00000508376_DTWD2_chr5_118183913_ENST00000515439_length(amino acids)=680AA_BP=581
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEIN
MATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKVQLKTSISSQYVIRMQPTNRCLSTLECAAVALSILEKNNYIQETLLRPL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for APC-DTWD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APC-DTWD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APC-DTWD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource