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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APC-KIAA0825 (FusionGDB2 ID:5383)

Fusion Gene Summary for APC-KIAA0825

check button Fusion gene summary
Fusion gene informationFusion gene name: APC-KIAA0825
Fusion gene ID: 5383
HgeneTgene
Gene symbol

APC

KIAA0825

Gene ID

5624

285600

Gene nameprotein C, inactivator of coagulation factors Va and VIIIaKIAA0825
SynonymsAPC|PC|PROC1|THPH3|THPH4C5orf36|PAPA10
Cytomap

2q14.3

5q15

Type of geneprotein-codingprotein-coding
Descriptionvitamin K-dependent protein CProtein C-Nagoyaactivated protein Canticoagulant protein Cautoprothrombin IIAblood coagulation factor XIVprepro-protein Ctype I protein Cuncharacterized protein KIAA0825
Modification date2020031320200313
UniProtAcc

P25054

Q8IV33

Ensembl transtripts involved in fusion geneENST00000257430, ENST00000457016, 
ENST00000508376, ENST00000505350, 
ENST00000312498, ENST00000329378, 
ENST00000427991, ENST00000513200, 
Fusion gene scores* DoF score14 X 10 X 8=11208 X 7 X 5=280
# samples 1411
** MAII scorelog2(14/1120*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/280*10)=-1.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APC [Title/Abstract] AND KIAA0825 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPC(112128226)-KIAA0825(93489829), # samples:4
Anticipated loss of major functional domain due to fusion event.APC-KIAA0825 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
APC-KIAA0825 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across APC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KIAA0825 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-CH-5788-01AAPCchr5

112128226

-KIAA0825chr5

93489829

-
ChimerDB4PRADTCGA-CH-5788-01AAPCchr5

112128226

+KIAA0825chr5

93489829

-
ChimerDB4PRADTCGA-CH-5788APCchr5

112128226

+KIAA0825chr5

93489829

-


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Fusion Gene ORF analysis for APC-KIAA0825

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000257430ENST00000312498APCchr5

112128226

+KIAA0825chr5

93489829

-
5CDS-intronENST00000257430ENST00000329378APCchr5

112128226

+KIAA0825chr5

93489829

-
5CDS-intronENST00000457016ENST00000312498APCchr5

112128226

+KIAA0825chr5

93489829

-
5CDS-intronENST00000457016ENST00000329378APCchr5

112128226

+KIAA0825chr5

93489829

-
5CDS-intronENST00000508376ENST00000312498APCchr5

112128226

+KIAA0825chr5

93489829

-
5CDS-intronENST00000508376ENST00000329378APCchr5

112128226

+KIAA0825chr5

93489829

-
Frame-shiftENST00000257430ENST00000427991APCchr5

112128226

+KIAA0825chr5

93489829

-
Frame-shiftENST00000457016ENST00000427991APCchr5

112128226

+KIAA0825chr5

93489829

-
Frame-shiftENST00000508376ENST00000427991APCchr5

112128226

+KIAA0825chr5

93489829

-
In-frameENST00000257430ENST00000513200APCchr5

112128226

+KIAA0825chr5

93489829

-
In-frameENST00000457016ENST00000513200APCchr5

112128226

+KIAA0825chr5

93489829

-
In-frameENST00000508376ENST00000513200APCchr5

112128226

+KIAA0825chr5

93489829

-
intron-3CDSENST00000505350ENST00000427991APCchr5

112128226

+KIAA0825chr5

93489829

-
intron-3CDSENST00000505350ENST00000513200APCchr5

112128226

+KIAA0825chr5

93489829

-
intron-intronENST00000505350ENST00000312498APCchr5

112128226

+KIAA0825chr5

93489829

-
intron-intronENST00000505350ENST00000329378APCchr5

112128226

+KIAA0825chr5

93489829

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000457016APCchr5112128226+ENST00000513200KIAA0825chr593489829-226811093801129249
ENST00000257430APCchr5112128226+ENST00000513200KIAA0825chr593489829-194478556805249
ENST00000508376APCchr5112128226+ENST00000513200KIAA0825chr593489829-2045886157906249

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000457016ENST00000513200APCchr5112128226+KIAA0825chr593489829-0.0008494960.9991505
ENST00000257430ENST00000513200APCchr5112128226+KIAA0825chr593489829-0.0007511960.9992488
ENST00000508376ENST00000513200APCchr5112128226+KIAA0825chr593489829-0.0008486990.99915135

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Fusion Genomic Features for APC-KIAA0825


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for APC-KIAA0825


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:112128226/chr5:93489829)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APC

P25054

KIAA0825

Q8IV33

FUNCTION: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+7162_612432844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+7162_612432844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+8172_612432844.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+716127_2482432844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+716127_2482432844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+817127_2482432844.0Coiled coilOntology_term=ECO:0000255
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+7161131_11562432844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+7161558_15772432844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+7161_7302432844.0Compositional biasNote=Leu-rich
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+716731_28322432844.0Compositional biasNote=Ser-rich
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+7161131_11562432844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+7161558_15772432844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+7161_7302432844.0Compositional biasNote=Leu-rich
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+716731_28322432844.0Compositional biasNote=Ser-rich
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+8171131_11562432844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+8171558_15772432844.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+8171_7302432844.0Compositional biasNote=Leu-rich
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+817731_28322432844.0Compositional biasNote=Ser-rich
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+7162803_28062432844.0MotifNote=Microtubule tip localization signal
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+7162841_28432432844.0MotifNote=PDZ-binding
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+7162803_28062432844.0MotifNote=Microtubule tip localization signal
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+7162841_28432432844.0MotifNote=PDZ-binding
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+8172803_28062432844.0MotifNote=Microtubule tip localization signal
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+8172841_28432432844.0MotifNote=PDZ-binding
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+7161866_18932432844.0RegionNote=Highly charged
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+716960_13372432844.0RegionNote=Responsible for down-regulation through a process mediated by direct ubiquitination
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+7161866_18932432844.0RegionNote=Highly charged
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+716960_13372432844.0RegionNote=Responsible for down-regulation through a process mediated by direct ubiquitination
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+8171866_18932432844.0RegionNote=Highly charged
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+817960_13372432844.0RegionNote=Responsible for down-regulation through a process mediated by direct ubiquitination
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+716453_4952432844.0RepeatNote=ARM 1
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+716505_5472432844.0RepeatNote=ARM 2
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+716548_5912432844.0RepeatNote=ARM 3
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+716592_6382432844.0RepeatNote=ARM 4
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+716639_6832432844.0RepeatNote=ARM 5
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+716684_7252432844.0RepeatNote=ARM 6
HgeneAPCchr5:112128226chr5:93489829ENST00000257430+716726_7672432844.0RepeatNote=ARM 7
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+716453_4952432844.0RepeatNote=ARM 1
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+716505_5472432844.0RepeatNote=ARM 2
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+716548_5912432844.0RepeatNote=ARM 3
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+716592_6382432844.0RepeatNote=ARM 4
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+716639_6832432844.0RepeatNote=ARM 5
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+716684_7252432844.0RepeatNote=ARM 6
HgeneAPCchr5:112128226chr5:93489829ENST00000457016+716726_7672432844.0RepeatNote=ARM 7
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+817453_4952432844.0RepeatNote=ARM 1
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+817505_5472432844.0RepeatNote=ARM 2
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+817548_5912432844.0RepeatNote=ARM 3
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+817592_6382432844.0RepeatNote=ARM 4
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+817639_6832432844.0RepeatNote=ARM 5
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+817684_7252432844.0RepeatNote=ARM 6
HgeneAPCchr5:112128226chr5:93489829ENST00000508376+817726_7672432844.0RepeatNote=ARM 7


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Fusion Gene Sequence for APC-KIAA0825


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5383_5383_1_APC-KIAA0825_APC_chr5_112128226_ENST00000257430_KIAA0825_chr5_93489829_ENST00000513200_length(transcript)=1944nt_BP=785nt
GGAGACAGAATGGAGGTGCTGCCGGACTCGGAAATGGGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGC
AAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCAT
CTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTC
TTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGAT
CTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTG
GATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAAC
TTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATG
AAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTC
AGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGGTGGGAAATGAAGAAGGATGAAACA
CTAGAAGAGGAAGAAAAAGCAATACTGGAGCACTTAAAACAAATTTGCACCCCACAGAACTCTTCTGCCTCAGATAACATAGAGGAACAG
TAATCTGCAGAAAACAGCAACAGCTTTATTTTAGGAAACAATCCCATGTAATGGAGTAGGATTTTTTACCATAGTCAGAATGAACCTCAT
ATGTGCTGTGAAGCATGAAACCAATGACTGAGTAATCTCTGTACTGAAAAGGAATACAGCACATAAAGGATAAGGTGCTACATATTTTTT
TATTTTAAAAATAATTTCAAATGTTTTTCTTTCCCCAATCTTTCTCTTTATATGATATAACTGCTGCCATCTCGTGTTCCCTTTGAATTA
TTTTTTTCTCCTTTCAGTCTTGAAGTATCTATGACAACAGGAAGAAATGTTCAGAAATTTTTTAAAGGATTTTTTAAATACAACATTTGG
ATGTTAAGTTGAGTGGAGTCACATAGCCCCAGGAGGTCATCTGAAATTTTTAATTTAATTTTGTTGTAGCTGTAGCCCAAGTCCCAATTT
TAATTGCCTTTACTATCCACAATTGTGTCAACTTTCCTCATTCAATTTATCTAATTATAGTCAAAAAAAAGCATTCTCCTGAACTATAAC
TTTAGTCACACCTCTGCTTGTAGTGGTTTTCAGTCTTCCTCCTAAACCAGAATCAAATTTCTACTCATACATATTCAGGTCCTATACCAA
ATGGCTCCATGTTCAGACAATTGCTTGCCATCCTCTTGGTTCAAGTCACATGCTTGCCATGTTTTCCCAATCAGAATCCATCTTTCTTCC
AAAATTAGGCTCAAAACTAATTCCAGCAATCTTTACCCCAAAGCTCATTAGCTCATATAATGTGTTACTTTAAAATTTTTTCATTGTATT
GATACACACACACAAAATAAGAAAACAGAACATGCTCTAGTACCCTCTCTGCCAAGGACAATTATAGATATTTATTATTTCCTTCCTATC
ACTGCCTGATATTAGATTATAAAGACATTGAAGATATTATGATATAATATGAAGTCTCCCTTTATAACTCCCTGTATGCCTACTACAGTG

>5383_5383_1_APC-KIAA0825_APC_chr5_112128226_ENST00000257430_KIAA0825_chr5_93489829_ENST00000513200_length(amino acids)=249AA_BP=
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL

--------------------------------------------------------------
>5383_5383_2_APC-KIAA0825_APC_chr5_112128226_ENST00000457016_KIAA0825_chr5_93489829_ENST00000513200_length(transcript)=2268nt_BP=1109nt
ACAAGATGGCGGAGGGCAAGTAGCAAGGGGGCGGGGTGTGGCCGCCGGAAGCCTAGCCGCTGCTCGGGGGGGACCTGCGGGCTCAGGCCC
GGGAGCTGCGGACCGAGGTTGGCTCGATGCTGTTCCCAGGTACTGTTGTTGGCTGTTGGTGAGGAAGGTGAAGCACTCAGTTGCCTTCTC
GGGCCTCGGCGCCCCCTATGTACGCCTCCCTGGGCTCGGGTCCGGTCGCCCCTTTGCCCGCTTCTGTACCACCCTCAGTTCTCGGGTCCT
GGAGCACCGGCGGCAGCAGGAGCTGCGTCCGGCAGGAGACGAAGAGCCCGGGCGGCGCTCGTACTTCTGGCCACTGGGCGAGCGTCTGGC
AGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCAGTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTC
GACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGAAACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAA
GTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTTATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTG
GAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAGCCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTC
CTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAGAGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGC
TTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTATTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTT
TAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCAATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAAC
TAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAATAGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGC
TTTTACAGTCCCAAGCAACAGAAGCAGAGGTGGGAAATGAAGAAGGATGAAACACTAGAAGAGGAAGAAAAAGCAATACTGGAGCACTTA
AAACAAATTTGCACCCCACAGAACTCTTCTGCCTCAGATAACATAGAGGAACAGTAATCTGCAGAAAACAGCAACAGCTTTATTTTAGGA
AACAATCCCATGTAATGGAGTAGGATTTTTTACCATAGTCAGAATGAACCTCATATGTGCTGTGAAGCATGAAACCAATGACTGAGTAAT
CTCTGTACTGAAAAGGAATACAGCACATAAAGGATAAGGTGCTACATATTTTTTTATTTTAAAAATAATTTCAAATGTTTTTCTTTCCCC
AATCTTTCTCTTTATATGATATAACTGCTGCCATCTCGTGTTCCCTTTGAATTATTTTTTTCTCCTTTCAGTCTTGAAGTATCTATGACA
ACAGGAAGAAATGTTCAGAAATTTTTTAAAGGATTTTTTAAATACAACATTTGGATGTTAAGTTGAGTGGAGTCACATAGCCCCAGGAGG
TCATCTGAAATTTTTAATTTAATTTTGTTGTAGCTGTAGCCCAAGTCCCAATTTTAATTGCCTTTACTATCCACAATTGTGTCAACTTTC
CTCATTCAATTTATCTAATTATAGTCAAAAAAAAGCATTCTCCTGAACTATAACTTTAGTCACACCTCTGCTTGTAGTGGTTTTCAGTCT
TCCTCCTAAACCAGAATCAAATTTCTACTCATACATATTCAGGTCCTATACCAAATGGCTCCATGTTCAGACAATTGCTTGCCATCCTCT
TGGTTCAAGTCACATGCTTGCCATGTTTTCCCAATCAGAATCCATCTTTCTTCCAAAATTAGGCTCAAAACTAATTCCAGCAATCTTTAC
CCCAAAGCTCATTAGCTCATATAATGTGTTACTTTAAAATTTTTTCATTGTATTGATACACACACACAAAATAAGAAAACAGAACATGCT
CTAGTACCCTCTCTGCCAAGGACAATTATAGATATTTATTATTTCCTTCCTATCACTGCCTGATATTAGATTATAAAGACATTGAAGATA
TTATGATATAATATGAAGTCTCCCTTTATAACTCCCTGTATGCCTACTACAGTGTTATTTCATCAAGTGGACAGTTAACGAACACAATTG

>5383_5383_2_APC-KIAA0825_APC_chr5_112128226_ENST00000457016_KIAA0825_chr5_93489829_ENST00000513200_length(amino acids)=249AA_BP=
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL

--------------------------------------------------------------
>5383_5383_3_APC-KIAA0825_APC_chr5_112128226_ENST00000508376_KIAA0825_chr5_93489829_ENST00000513200_length(transcript)=2045nt_BP=886nt
GAATGGAGGTGCTGCCGGACTCGGAAATGGGGACACATGCATTGGTGGCCAAAAGAGAGAGGAGACAAAACCGCTGCAGATGGCTGATGT
GAATCTAGTGGAAAGAGCTACTGGGGATGAGAGAAAGAGGAGGAGGCAGGTCCAAGGGTAGCCAAGGATGGCTGCAGCTTCATATGATCA
GTTGTTAAAGCAAGTTGAGGCACTGAAGATGGAGAACTCAAATCTTCGACAAGAGCTAGAAGATAATTCCAATCATCTTACAAAACTGGA
AACTGAGGCATCTAATATGAAGGAAGTACTTAAACAACTACAAGGAAGTATTGAAGATGAAGCTATGGCTTCTTCTGGACAGATTGATTT
ATTAGAGCGTCTTAAAGAGCTTAACTTAGATAGCAGTAATTTCCCTGGAGTAAAACTGCGGTCAAAAATGTCCCTCCGTTCTTATGGAAG
CCGGGAAGGATCTGTATCAAGCCGTTCTGGAGAGTGCAGTCCTGTTCCTATGGGTTCATTTCCAAGAAGAGGGTTTGTAAATGGAAGCAG
AGAAAGTACTGGATATTTAGAAGAACTTGAGAAAGAGAGGTCATTGCTTCTTGCTGATCTTGACAAAGAAGAAAAGGAAAAAGACTGGTA
TTACGCTCAACTTCAGAATCTCACTAAAAGAATAGATAGTCTTCCTTTAACTGAAAATTTTTCCTTACAAACAGATATGACCAGAAGGCA
ATTGGAATATGAAGCAAGGCAAATCAGAGTTGCGATGGAAGAACAACTAGGTACCTGCCAGGATATGGAAAAACGAGCACAGCGAAGAAT
AGCCAGAATTCAGCAAATCGAAAAGGACATACTTCGTATACGACAGCTTTTACAGTCCCAAGCAACAGAAGCAGAGGTGGGAAATGAAGA
AGGATGAAACACTAGAAGAGGAAGAAAAAGCAATACTGGAGCACTTAAAACAAATTTGCACCCCACAGAACTCTTCTGCCTCAGATAACA
TAGAGGAACAGTAATCTGCAGAAAACAGCAACAGCTTTATTTTAGGAAACAATCCCATGTAATGGAGTAGGATTTTTTACCATAGTCAGA
ATGAACCTCATATGTGCTGTGAAGCATGAAACCAATGACTGAGTAATCTCTGTACTGAAAAGGAATACAGCACATAAAGGATAAGGTGCT
ACATATTTTTTTATTTTAAAAATAATTTCAAATGTTTTTCTTTCCCCAATCTTTCTCTTTATATGATATAACTGCTGCCATCTCGTGTTC
CCTTTGAATTATTTTTTTCTCCTTTCAGTCTTGAAGTATCTATGACAACAGGAAGAAATGTTCAGAAATTTTTTAAAGGATTTTTTAAAT
ACAACATTTGGATGTTAAGTTGAGTGGAGTCACATAGCCCCAGGAGGTCATCTGAAATTTTTAATTTAATTTTGTTGTAGCTGTAGCCCA
AGTCCCAATTTTAATTGCCTTTACTATCCACAATTGTGTCAACTTTCCTCATTCAATTTATCTAATTATAGTCAAAAAAAAGCATTCTCC
TGAACTATAACTTTAGTCACACCTCTGCTTGTAGTGGTTTTCAGTCTTCCTCCTAAACCAGAATCAAATTTCTACTCATACATATTCAGG
TCCTATACCAAATGGCTCCATGTTCAGACAATTGCTTGCCATCCTCTTGGTTCAAGTCACATGCTTGCCATGTTTTCCCAATCAGAATCC
ATCTTTCTTCCAAAATTAGGCTCAAAACTAATTCCAGCAATCTTTACCCCAAAGCTCATTAGCTCATATAATGTGTTACTTTAAAATTTT
TTCATTGTATTGATACACACACACAAAATAAGAAAACAGAACATGCTCTAGTACCCTCTCTGCCAAGGACAATTATAGATATTTATTATT
TCCTTCCTATCACTGCCTGATATTAGATTATAAAGACATTGAAGATATTATGATATAATATGAAGTCTCCCTTTATAACTCCCTGTATGC

>5383_5383_3_APC-KIAA0825_APC_chr5_112128226_ENST00000508376_KIAA0825_chr5_93489829_ENST00000513200_length(amino acids)=249AA_BP=
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSK
MSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL

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Fusion Gene PPI Analysis for APC-KIAA0825


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APC-KIAA0825


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APC-KIAA0825


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource