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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MKL2-ZNF200 (FusionGDB2 ID:54078)

Fusion Gene Summary for MKL2-ZNF200

check button Fusion gene summary
Fusion gene informationFusion gene name: MKL2-ZNF200
Fusion gene ID: 54078
HgeneTgene
Gene symbol

MKL2

ZNF200

Gene ID

57496

7752

Gene namemyocardin related transcription factor Bzinc finger protein 200
SynonymsMKL2|MRTF-B|NPD001-
Cytomap

16p13.12

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionmyocardin-related transcription factor BCTA-276F8.1MKL and myocardin family member 2MKL/myocardin like 2MKL/myocardin-like protein 2MKL1/myocardin like 2megakaryoblastic leukemia 2zinc finger protein 200
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000318282, ENST00000341243, 
ENST00000571589, ENST00000572567, 
ENST00000573051, ENST00000574045, 
ENST00000575537, 		ENST00000396871, 
ENST00000414144, ENST00000396870, 
ENST00000431561, ENST00000575948, 
ENST00000396868, 
Fusion gene scores* DoF score19 X 10 X 11=20902 X 1 X 2=4
# samples 202
** MAII scorelog2(20/2090*10)=-3.38543103719352
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: MKL2 [Title/Abstract] AND ZNF200 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMKL2(14328140)-ZNF200(3285360), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMKL2

GO:0045844

positive regulation of striated muscle tissue development

14565952

HgeneMKL2

GO:0045944

positive regulation of transcription by RNA polymerase II

14565952


check buttonFusion gene breakpoints across MKL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF200 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-CS-5397-01AMKL2chr16

14328140

-ZNF200chr16

3285360

-
ChimerDB4LGGTCGA-CS-5397-01AMKL2chr16

14328140

+ZNF200chr16

3285360

-


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Fusion Gene ORF analysis for MKL2-ZNF200

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000318282ENST00000396871MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-5UTRENST00000318282ENST00000414144MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-5UTRENST00000341243ENST00000396871MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-5UTRENST00000341243ENST00000414144MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-5UTRENST00000571589ENST00000396871MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-5UTRENST00000571589ENST00000414144MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-5UTRENST00000572567ENST00000396871MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-5UTRENST00000572567ENST00000414144MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-5UTRENST00000573051ENST00000396871MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-5UTRENST00000573051ENST00000414144MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-5UTRENST00000574045ENST00000396871MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-5UTRENST00000574045ENST00000414144MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000318282ENST00000396870MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000318282ENST00000431561MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000318282ENST00000575948MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000341243ENST00000396870MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000341243ENST00000431561MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000341243ENST00000575948MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000571589ENST00000396870MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000571589ENST00000431561MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000571589ENST00000575948MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000572567ENST00000396870MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000572567ENST00000431561MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000572567ENST00000575948MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000573051ENST00000396870MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000573051ENST00000431561MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000573051ENST00000575948MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000574045ENST00000396870MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000574045ENST00000431561MKL2chr16

14328140

+ZNF200chr16

3285360

-
5CDS-intronENST00000574045ENST00000575948MKL2chr16

14328140

+ZNF200chr16

3285360

-
In-frameENST00000318282ENST00000396868MKL2chr16

14328140

+ZNF200chr16

3285360

-
In-frameENST00000341243ENST00000396868MKL2chr16

14328140

+ZNF200chr16

3285360

-
In-frameENST00000571589ENST00000396868MKL2chr16

14328140

+ZNF200chr16

3285360

-
In-frameENST00000572567ENST00000396868MKL2chr16

14328140

+ZNF200chr16

3285360

-
In-frameENST00000573051ENST00000396868MKL2chr16

14328140

+ZNF200chr16

3285360

-
In-frameENST00000574045ENST00000396868MKL2chr16

14328140

+ZNF200chr16

3285360

-
intron-3CDSENST00000575537ENST00000396868MKL2chr16

14328140

+ZNF200chr16

3285360

-
intron-5UTRENST00000575537ENST00000396871MKL2chr16

14328140

+ZNF200chr16

3285360

-
intron-5UTRENST00000575537ENST00000414144MKL2chr16

14328140

+ZNF200chr16

3285360

-
intron-intronENST00000575537ENST00000396870MKL2chr16

14328140

+ZNF200chr16

3285360

-
intron-intronENST00000575537ENST00000431561MKL2chr16

14328140

+ZNF200chr16

3285360

-
intron-intronENST00000575537ENST00000575948MKL2chr16

14328140

+ZNF200chr16

3285360

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000571589MKL2chr1614328140+ENST00000396868ZNF200chr163285360-4085100312912517408
ENST00000574045MKL2chr1614328140+ENST00000396868ZNF200chr163285360-406898612742500408
ENST00000318282MKL2chr1614328140+ENST00000396868ZNF200chr163285360-404396112492475408
ENST00000572567MKL2chr1614328140+ENST00000396868ZNF200chr163285360-407899612842510408
ENST00000341243MKL2chr1614328140+ENST00000396868ZNF200chr163285360-388079810862312408
ENST00000573051MKL2chr1614328140+ENST00000396868ZNF200chr163285360-391883611242350408

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000571589ENST00000396868MKL2chr1614328140+ZNF200chr163285360-0.0003151780.9996848
ENST00000574045ENST00000396868MKL2chr1614328140+ZNF200chr163285360-0.0003103660.9996897
ENST00000318282ENST00000396868MKL2chr1614328140+ZNF200chr163285360-0.0003001540.99969983
ENST00000572567ENST00000396868MKL2chr1614328140+ZNF200chr163285360-0.0003508480.99964917
ENST00000341243ENST00000396868MKL2chr1614328140+ZNF200chr163285360-0.0003363360.9996637
ENST00000573051ENST00000396868MKL2chr1614328140+ZNF200chr163285360-0.0003412580.9996587

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Fusion Genomic Features for MKL2-ZNF200


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MKL2-ZNF200


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:14328140/chr16:3285360)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMKL2chr16:14328140chr16:3285360ENST00000318282+816128_1532771050.0RepeatNote=RPEL 3
HgeneMKL2chr16:14328140chr16:3285360ENST00000318282+81640_652771050.0RepeatNote=RPEL 1
HgeneMKL2chr16:14328140chr16:3285360ENST00000318282+81684_1092771050.0RepeatNote=RPEL 2
HgeneMKL2chr16:14328140chr16:3285360ENST00000341243+715128_1532661089.0RepeatNote=RPEL 3
HgeneMKL2chr16:14328140chr16:3285360ENST00000341243+71540_652661089.0RepeatNote=RPEL 1
HgeneMKL2chr16:14328140chr16:3285360ENST00000341243+71584_1092661089.0RepeatNote=RPEL 2
HgeneMKL2chr16:14328140chr16:3285360ENST00000573051+79128_153226379.0RepeatNote=RPEL 3
HgeneMKL2chr16:14328140chr16:3285360ENST00000573051+7940_65226379.0RepeatNote=RPEL 1
HgeneMKL2chr16:14328140chr16:3285360ENST00000573051+7984_109226379.0RepeatNote=RPEL 2
HgeneMKL2chr16:14328140chr16:3285360ENST00000574045+917128_1532771050.0RepeatNote=RPEL 3
HgeneMKL2chr16:14328140chr16:3285360ENST00000574045+91740_652771050.0RepeatNote=RPEL 1
HgeneMKL2chr16:14328140chr16:3285360ENST00000574045+91784_1092771050.0RepeatNote=RPEL 2
TgeneZNF200chr16:14328140chr16:3285360ENST00000396868-15252_2740395.0Zinc fingerC2H2-type 1
TgeneZNF200chr16:14328140chr16:3285360ENST00000396868-15280_3020395.0Zinc fingerC2H2-type 2
TgeneZNF200chr16:14328140chr16:3285360ENST00000396868-15308_3300395.0Zinc fingerC2H2-type 3
TgeneZNF200chr16:14328140chr16:3285360ENST00000396868-15336_3580395.0Zinc fingerC2H2-type 4
TgeneZNF200chr16:14328140chr16:3285360ENST00000396868-15364_3860395.0Zinc fingerC2H2-type 5
TgeneZNF200chr16:14328140chr16:3285360ENST0000039687005252_2740395.0Zinc fingerC2H2-type 1
TgeneZNF200chr16:14328140chr16:3285360ENST0000039687005280_3020395.0Zinc fingerC2H2-type 2
TgeneZNF200chr16:14328140chr16:3285360ENST0000039687005308_3300395.0Zinc fingerC2H2-type 3
TgeneZNF200chr16:14328140chr16:3285360ENST0000039687005336_3580395.0Zinc fingerC2H2-type 4
TgeneZNF200chr16:14328140chr16:3285360ENST0000039687005364_3860395.0Zinc fingerC2H2-type 5
TgeneZNF200chr16:14328140chr16:3285360ENST0000039687105252_2740395.0Zinc fingerC2H2-type 1
TgeneZNF200chr16:14328140chr16:3285360ENST0000039687105280_3020395.0Zinc fingerC2H2-type 2
TgeneZNF200chr16:14328140chr16:3285360ENST0000039687105308_3300395.0Zinc fingerC2H2-type 3
TgeneZNF200chr16:14328140chr16:3285360ENST0000039687105336_3580395.0Zinc fingerC2H2-type 4
TgeneZNF200chr16:14328140chr16:3285360ENST0000039687105364_3860395.0Zinc fingerC2H2-type 5
TgeneZNF200chr16:14328140chr16:3285360ENST0000041414405252_2740396.0Zinc fingerC2H2-type 1
TgeneZNF200chr16:14328140chr16:3285360ENST0000041414405280_3020396.0Zinc fingerC2H2-type 2
TgeneZNF200chr16:14328140chr16:3285360ENST0000041414405308_3300396.0Zinc fingerC2H2-type 3
TgeneZNF200chr16:14328140chr16:3285360ENST0000041414405336_3580396.0Zinc fingerC2H2-type 4
TgeneZNF200chr16:14328140chr16:3285360ENST0000041414405364_3860396.0Zinc fingerC2H2-type 5
TgeneZNF200chr16:14328140chr16:3285360ENST0000043156105252_2740396.0Zinc fingerC2H2-type 1
TgeneZNF200chr16:14328140chr16:3285360ENST0000043156105280_3020396.0Zinc fingerC2H2-type 2
TgeneZNF200chr16:14328140chr16:3285360ENST0000043156105308_3300396.0Zinc fingerC2H2-type 3
TgeneZNF200chr16:14328140chr16:3285360ENST0000043156105336_3580396.0Zinc fingerC2H2-type 4
TgeneZNF200chr16:14328140chr16:3285360ENST0000043156105364_3860396.0Zinc fingerC2H2-type 5
TgeneZNF200chr16:14328140chr16:3285360ENST0000057594805252_2740395.0Zinc fingerC2H2-type 1
TgeneZNF200chr16:14328140chr16:3285360ENST0000057594805280_3020395.0Zinc fingerC2H2-type 2
TgeneZNF200chr16:14328140chr16:3285360ENST0000057594805308_3300395.0Zinc fingerC2H2-type 3
TgeneZNF200chr16:14328140chr16:3285360ENST0000057594805336_3580395.0Zinc fingerC2H2-type 4
TgeneZNF200chr16:14328140chr16:3285360ENST0000057594805364_3860395.0Zinc fingerC2H2-type 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMKL2chr16:14328140chr16:3285360ENST00000318282+816545_6012771050.0Coiled coilOntology_term=ECO:0000255
HgeneMKL2chr16:14328140chr16:3285360ENST00000341243+715545_6012661089.0Coiled coilOntology_term=ECO:0000255
HgeneMKL2chr16:14328140chr16:3285360ENST00000573051+79545_601226379.0Coiled coilOntology_term=ECO:0000255
HgeneMKL2chr16:14328140chr16:3285360ENST00000574045+917545_6012771050.0Coiled coilOntology_term=ECO:0000255
HgeneMKL2chr16:14328140chr16:3285360ENST00000318282+816671_7872771050.0Compositional biasNote=Gln-rich
HgeneMKL2chr16:14328140chr16:3285360ENST00000341243+715671_7872661089.0Compositional biasNote=Gln-rich
HgeneMKL2chr16:14328140chr16:3285360ENST00000573051+79671_787226379.0Compositional biasNote=Gln-rich
HgeneMKL2chr16:14328140chr16:3285360ENST00000574045+917671_7872771050.0Compositional biasNote=Gln-rich
HgeneMKL2chr16:14328140chr16:3285360ENST00000318282+816389_4232771050.0DomainSAP
HgeneMKL2chr16:14328140chr16:3285360ENST00000341243+715389_4232661089.0DomainSAP
HgeneMKL2chr16:14328140chr16:3285360ENST00000573051+79389_423226379.0DomainSAP
HgeneMKL2chr16:14328140chr16:3285360ENST00000574045+917389_4232771050.0DomainSAP


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Fusion Gene Sequence for MKL2-ZNF200


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54078_54078_1_MKL2-ZNF200_MKL2_chr16_14328140_ENST00000318282_ZNF200_chr16_3285360_ENST00000396868_length(transcript)=4043nt_BP=961nt
AGGTTCACAATAAAGGTGCTAAGAAAGAGAATGTAAGACAGGAAAATAATTAAATATTCTTACCGAGTGTCTTCAATAGGCCGTGTTTAA
GAGGCGTCTTACACTCCCTGTTGCCAGTGGCTGGAACACAATGGATCACACAGGGGCGATAGACACCGAGGATGAAGTGGGACCTTTAGC
CCATCTTGCTCCAAGTCCTCAGAGTGAAGCTGTGGCTCATGAATTCCAGGAACTCTCCTTGCAGTCCAGTCAAAACTTACCCCCTCTGAA
CGAAAGGAAAAATGTGCTCCAGCTGAGGCTGCAACAAAGGAGGACGAGAGAACAACTAGTGGACCAGGGCATCATGCCACCTTTGAAGAG
CCCAGCGGCATTCCATGAACAGATAAAAAGCTTGGAACGAGCCAGAACTGAAAACTTTTTGAAACACAAGATTCGGAGTCGACCAGATCG
TTCTGAACTTGTCAGGATGCACATTTTAGAAGAAACATTTGCAGAGCCATCCCTGCAGGCTACTCAGATGAAGTTGAAAAGAGCTCGACT
AGCAGATGATCTGAATGAAAAGATTGCTCAAAGACCTGGTCCTATGGAGCTGGTAGAGAAAAACATCCTTCCTGTGGACTCCAGTGTTAA
AGAAGCAATTATAGGCGTTGGGAAGGAGGACTATCCCCACACTCAGGGCGATTTCTCATTTGATGAAGACAGCAGTGACGCTTTGTCTCC
GGACCAGCCTGCGAGTCAGGAGTCACAGGGGTCAGCCGCGTCCCCAAGTGAGCCAAAAGTTAGTGAATCGCCATCTCCTGTGACTACAAA
CACTCCAGCGCAGTTTGCTTCAGTGTCCCCAACAGTTCCTGAATTCTTGAAAACTCCTCCAACTGCAGATCAGCCTCCCCCACGGCCTGC
AGCTCCTGTCCTCCCCACAAACACTGTGTCCTCAGCAAAGCCTGGCCCAGCACTGGTGAAGGCAGAACCACAGAGAGGCTACAGCCGTCC
TGGCCTCCCTCCGGCCCTGAGAGCTCCTCTGGCCTGTCTCAAGTCTTAACGTCTCAAGCGCAGACTGCCGGCTCCGAACGGGGAGACCAG
GCTTCTGCACCGGAAACAAGGCACCGGTTGTGACGTCACAGCCGCAGAGCGCCCGACTTCCCAGAAGGCACCGAGTCCCTGCCGTTCTCC
TCAACTGGCGGCGGCGCGAACGAATAGTCGCCGGCGACCTCTTGGCTCTCTGGCAGATTTCCTCTAGTAAGAGGTGGCTCTGGAGGCCCC
GCGAAACGAGTGTGGTGTGTGGTTGCAAGGCATGATGGCTGCAAAAGTGGTTCCTATGCCCCCAAAGCCAAAGCAGTCCTTTATACTGAG
AGTTCCGCCAGACTCCAAGCTGGGCCAAGACCTACTTCGAGATGCCACTAACGGGCCCAAGACCATCCACCAGCTAGTGCTGGAGCACTT
CCTCACCTTCTTGCCCAAGCCAAGCCTGGTCCAGCCCAGTCAGAAAGTCAAGGAGACCTTGGTTATTATGAAAGATGTGAGCTCAAGCCT
TCAGAACAGAGTGCATCCTCGTCCCTTGGTGAAGCTTCTGCCCAAAGGAGTCCAAAAGGAACAAGAGACAGTGTCTCTGTATTTGAAAGC
TAACCCTGAGCTGGTGGTCTTTGAGGATTTGAATGTATTTCACTGCCAGGAAGAATGTGTGAGCTTGGATCCTACTCAACAACTCACGTC
AGAGAAGGAAGATGACAGCAGTGTCGGGGAAATGATGTTACTGGCAGTCAATGGCAGTAATCCTGAAGGTGAAGATCCTGAGAGGGAACC
TGTAGAAAATGAAGATTATAGAGAAAAGTCTTCAGATGATGATGAAATGGATTCTTCCTTGGTCTCTCAGCAGCCTCCCGATAACCAGGA
AAAGGAACGACTAAATACATCCATTCCACAAAAAAGGAAAATGAGAAATCTGTTAGTTACCATTGAGAATGATACTCCTCTAGAGGAACT
CTCAAAATATGTAGACATCAGTATTATTGCCCTTACTCGAAATCGGAGGACAAGGAGATGGTACACTTGTCCACTGTGTGGGAAACAGTT
TAATGAAAGTTCTTACCTCATTTCCCACCAGAGGACCCACACTGGAGAAAAACCCTATGACTGTAATCACTGTGGGAAAAGCTTCAATCA
TAAAACAAACCTCAATAAACATGAGCGAATTCATACAGGAGAGAAACCTTATTCCTGTTCTCAGTGTGGAAAAAACTTCCGTCAGAATTC
TCATCGGAGTCGTCATGAAGGAATCCATATAAGGGAGAAGATATTTAAGTGTCCAGAATGTGGGAAAACCTTCCCAAAGAATGAGGAGTT
TGTGCTTCATCTGCAGAGTCATGAGGCTGAGAGACCATATGGTTGCAAAAAATGTGGGAGAAGATTTGGTCGGCTGTCAAACTGTACCCG
GCATGAGAAAACCCACTCAGCCTGTAAGACCCGAAAGCAGAAGTAATACTGGGAACCCTTTCTGGGTCTGATGGTGCTGCCTCAACCTGA
GAGCTTTCATAAGTAGTTCTGAATTCCCAAGCTGCCTAAAAAGGTATAAATGTGTAAAAATCTCATTATTGCCAAAATTGGATAAATGCC
CATCTTAGCTAAAACCTCAAATTGCTAGAAAATTCACAGGGAAGAAAACATTTCAAGGGCTATACCTCAGCATCTAGGCTTTTTGGACTA
AGGAGCTTTCCTTTTTGAAGTTATATGATAATGTACAGGTCACAGATCCCCTTTCCCAACACTTTGAAGATGAATCTGGAGTCTGCTTAC
TTGGAAGGCAAAGAGTGACTTGTGTCTATTGAAAGTATATCCGTTTTCCCCCCACATGGGGATTCATACTTGAGAAATAGTGCAAAGATG
CTTATCTGGAACTGTGTTCTGGTGAAAGAACCAAATTACTGGCTTGTTAGCCAACAGCTTCTGATAGCAATTCATATAACCCTCTAAGAA
TACCTGTTTAAGTCTTGAGTGTTGAAAGGAATTGTTTACTTTGGAATATAGGAAAACAGTTGAATGTCAGACTCTCATTTGTATGTGATC
TAAATTTGCAATCAATTTCAATAATATTTACAATTTGTGATAAAACTGACTTTTACAGATTCCTTTTCACAACATAATTTAGGTGTCTAC
TGTTCTTATTGTATTTTGTTCTGCTGTTGATCTCTCCAGCAGCCGTCTCATGCTTCTCCCTTGCTAAAAGAAGTTTGGATTACTCAGGCA
GGGCCATCCAGCCCCACCACTAGAAAAGCTCTTCAGAATCTTGTCCCTCTGTTGAGCCCAGATCTCATGTGCTACGAAGGAAACCCCAAG
ACCCAGAGAGGAAGGGTCAACCTGGAGGCAGGAAAAAGTTGGCTTGGATCCATGTCTCATCAATAACCTTACCATATGCTTAGGTCCCCT
CTATGCTGTCATCAGACCTTTGGCAATGGGGTGGTCACTACCTCACAAGGCAAAGTGTTGTATGATTAGAAATTACGTCTCCAGTGGTTA
GCTCACATTGCCTCTCAAGAGACAGGTTTCCAGGTGTCTTCATTGTAGTGGGTATTAATTGTCTTCAGCCTCTTGATATCCATACCTTCC
TGTCCTCTGCCTAGAAGCAAGGCCAGCGGTGCCTTTACGGACTGATCGTGTGGTGCGATTTAGGGATTCTTCAGTTTTGCTTGCTTTAGG
TTTCCAAAAGTTATACATTGGTGTTTTGATTGGAATAAAGAAATCCTATAAGCTATTTGGGAAAAATTATAGTGTATGTTTCCCATCCAG
AAACATGCCTTTCTATTTATTAGAGTATTATATTCCTGTGAAAATTTTTCTAATTTTCTTCACTTGTTTTACACAATTTTGTTATTGTAG
TTTTTTCCATTATATTTTTATAGTTGATTATTGCTTTTACATGGGAAAGTTATTTTTAATTATATATTTGTATAGTCATCTCACTGTTGT

>54078_54078_1_MKL2-ZNF200_MKL2_chr16_14328140_ENST00000318282_ZNF200_chr16_3285360_ENST00000396868_length(amino acids)=408AA_BP=262
MEAPRNECGVWLQGMMAAKVVPMPPKPKQSFILRVPPDSKLGQDLLRDATNGPKTIHQLVLEHFLTFLPKPSLVQPSQKVKETLVIMKDV
SSSLQNRVHPRPLVKLLPKGVQKEQETVSLYLKANPELVVFEDLNVFHCQEECVSLDPTQQLTSEKEDDSSVGEMMLLAVNGSNPEGEDP
EREPVENEDYREKSSDDDEMDSSLVSQQPPDNQEKERLNTSIPQKRKMRNLLVTIENDTPLEELSKYVDISIIALTRNRRTRRWYTCPLC
GKQFNESSYLISHQRTHTGEKPYDCNHCGKSFNHKTNLNKHERIHTGEKPYSCSQCGKNFRQNSHRSRHEGIHIREKIFKCPECGKTFPK

--------------------------------------------------------------
>54078_54078_2_MKL2-ZNF200_MKL2_chr16_14328140_ENST00000341243_ZNF200_chr16_3285360_ENST00000396868_length(transcript)=3880nt_BP=798nt
ATGATCGATAGCTCCAAGAAGCAGCAACAGGGCTTCCCAGAGATTTTAACTGCTGGGGATTTTGAACCATTAAAAGAAAAGGAATGCCTT
GAGGGGAGCAACCAGAAAAGTCTCAAGGAAGTGCTCCAGCTGAGGCTGCAACAAAGGAGGACGAGAGAACAACTAGTGGACCAGGGCATC
ATGCCACCTTTGAAGAGCCCAGCGGCATTCCATGAACAGATAAAAAGCTTGGAACGAGCCAGAACTGAAAACTTTTTGAAACACAAGATT
CGGAGTCGACCAGATCGTTCTGAACTTGTCAGGATGCACATTTTAGAAGAAACATTTGCAGAGCCATCCCTGCAGGCTACTCAGATGAAG
TTGAAAAGAGCTCGACTAGCAGATGATCTGAATGAAAAGATTGCTCAAAGACCTGGTCCTATGGAGCTGGTAGAGAAAAACATCCTTCCT
GTGGACTCCAGTGTTAAAGAAGCAATTATAGGCGTTGGGAAGGAGGACTATCCCCACACTCAGGGCGATTTCTCATTTGATGAAGACAGC
AGTGACGCTTTGTCTCCGGACCAGCCTGCGAGTCAGGAGTCACAGGGGTCAGCCGCGTCCCCAAGTGAGCCAAAAGTTAGTGAATCGCCA
TCTCCTGTGACTACAAACACTCCAGCGCAGTTTGCTTCAGTGTCCCCAACAGTTCCTGAATTCTTGAAAACTCCTCCAACTGCAGATCAG
CCTCCCCCACGGCCTGCAGCTCCTGTCCTCCCCACAAACACTGTGTCCTCAGCAAAGCCTGGCCCAGCACTGGTGAAGGCAGAACCACAG
AGAGGCTACAGCCGTCCTGGCCTCCCTCCGGCCCTGAGAGCTCCTCTGGCCTGTCTCAAGTCTTAACGTCTCAAGCGCAGACTGCCGGCT
CCGAACGGGGAGACCAGGCTTCTGCACCGGAAACAAGGCACCGGTTGTGACGTCACAGCCGCAGAGCGCCCGACTTCCCAGAAGGCACCG
AGTCCCTGCCGTTCTCCTCAACTGGCGGCGGCGCGAACGAATAGTCGCCGGCGACCTCTTGGCTCTCTGGCAGATTTCCTCTAGTAAGAG
GTGGCTCTGGAGGCCCCGCGAAACGAGTGTGGTGTGTGGTTGCAAGGCATGATGGCTGCAAAAGTGGTTCCTATGCCCCCAAAGCCAAAG
CAGTCCTTTATACTGAGAGTTCCGCCAGACTCCAAGCTGGGCCAAGACCTACTTCGAGATGCCACTAACGGGCCCAAGACCATCCACCAG
CTAGTGCTGGAGCACTTCCTCACCTTCTTGCCCAAGCCAAGCCTGGTCCAGCCCAGTCAGAAAGTCAAGGAGACCTTGGTTATTATGAAA
GATGTGAGCTCAAGCCTTCAGAACAGAGTGCATCCTCGTCCCTTGGTGAAGCTTCTGCCCAAAGGAGTCCAAAAGGAACAAGAGACAGTG
TCTCTGTATTTGAAAGCTAACCCTGAGCTGGTGGTCTTTGAGGATTTGAATGTATTTCACTGCCAGGAAGAATGTGTGAGCTTGGATCCT
ACTCAACAACTCACGTCAGAGAAGGAAGATGACAGCAGTGTCGGGGAAATGATGTTACTGGCAGTCAATGGCAGTAATCCTGAAGGTGAA
GATCCTGAGAGGGAACCTGTAGAAAATGAAGATTATAGAGAAAAGTCTTCAGATGATGATGAAATGGATTCTTCCTTGGTCTCTCAGCAG
CCTCCCGATAACCAGGAAAAGGAACGACTAAATACATCCATTCCACAAAAAAGGAAAATGAGAAATCTGTTAGTTACCATTGAGAATGAT
ACTCCTCTAGAGGAACTCTCAAAATATGTAGACATCAGTATTATTGCCCTTACTCGAAATCGGAGGACAAGGAGATGGTACACTTGTCCA
CTGTGTGGGAAACAGTTTAATGAAAGTTCTTACCTCATTTCCCACCAGAGGACCCACACTGGAGAAAAACCCTATGACTGTAATCACTGT
GGGAAAAGCTTCAATCATAAAACAAACCTCAATAAACATGAGCGAATTCATACAGGAGAGAAACCTTATTCCTGTTCTCAGTGTGGAAAA
AACTTCCGTCAGAATTCTCATCGGAGTCGTCATGAAGGAATCCATATAAGGGAGAAGATATTTAAGTGTCCAGAATGTGGGAAAACCTTC
CCAAAGAATGAGGAGTTTGTGCTTCATCTGCAGAGTCATGAGGCTGAGAGACCATATGGTTGCAAAAAATGTGGGAGAAGATTTGGTCGG
CTGTCAAACTGTACCCGGCATGAGAAAACCCACTCAGCCTGTAAGACCCGAAAGCAGAAGTAATACTGGGAACCCTTTCTGGGTCTGATG
GTGCTGCCTCAACCTGAGAGCTTTCATAAGTAGTTCTGAATTCCCAAGCTGCCTAAAAAGGTATAAATGTGTAAAAATCTCATTATTGCC
AAAATTGGATAAATGCCCATCTTAGCTAAAACCTCAAATTGCTAGAAAATTCACAGGGAAGAAAACATTTCAAGGGCTATACCTCAGCAT
CTAGGCTTTTTGGACTAAGGAGCTTTCCTTTTTGAAGTTATATGATAATGTACAGGTCACAGATCCCCTTTCCCAACACTTTGAAGATGA
ATCTGGAGTCTGCTTACTTGGAAGGCAAAGAGTGACTTGTGTCTATTGAAAGTATATCCGTTTTCCCCCCACATGGGGATTCATACTTGA
GAAATAGTGCAAAGATGCTTATCTGGAACTGTGTTCTGGTGAAAGAACCAAATTACTGGCTTGTTAGCCAACAGCTTCTGATAGCAATTC
ATATAACCCTCTAAGAATACCTGTTTAAGTCTTGAGTGTTGAAAGGAATTGTTTACTTTGGAATATAGGAAAACAGTTGAATGTCAGACT
CTCATTTGTATGTGATCTAAATTTGCAATCAATTTCAATAATATTTACAATTTGTGATAAAACTGACTTTTACAGATTCCTTTTCACAAC
ATAATTTAGGTGTCTACTGTTCTTATTGTATTTTGTTCTGCTGTTGATCTCTCCAGCAGCCGTCTCATGCTTCTCCCTTGCTAAAAGAAG
TTTGGATTACTCAGGCAGGGCCATCCAGCCCCACCACTAGAAAAGCTCTTCAGAATCTTGTCCCTCTGTTGAGCCCAGATCTCATGTGCT
ACGAAGGAAACCCCAAGACCCAGAGAGGAAGGGTCAACCTGGAGGCAGGAAAAAGTTGGCTTGGATCCATGTCTCATCAATAACCTTACC
ATATGCTTAGGTCCCCTCTATGCTGTCATCAGACCTTTGGCAATGGGGTGGTCACTACCTCACAAGGCAAAGTGTTGTATGATTAGAAAT
TACGTCTCCAGTGGTTAGCTCACATTGCCTCTCAAGAGACAGGTTTCCAGGTGTCTTCATTGTAGTGGGTATTAATTGTCTTCAGCCTCT
TGATATCCATACCTTCCTGTCCTCTGCCTAGAAGCAAGGCCAGCGGTGCCTTTACGGACTGATCGTGTGGTGCGATTTAGGGATTCTTCA
GTTTTGCTTGCTTTAGGTTTCCAAAAGTTATACATTGGTGTTTTGATTGGAATAAAGAAATCCTATAAGCTATTTGGGAAAAATTATAGT
GTATGTTTCCCATCCAGAAACATGCCTTTCTATTTATTAGAGTATTATATTCCTGTGAAAATTTTTCTAATTTTCTTCACTTGTTTTACA
CAATTTTGTTATTGTAGTTTTTTCCATTATATTTTTATAGTTGATTATTGCTTTTACATGGGAAAGTTATTTTTAATTATATATTTGTAT
AGTCATCTCACTGTTGTTAATTTTCAATAGTTTGTTGGTTTAGTTCTGTTAACTTTTGGTAAAATGACACCATCTACAAAGAATAGTTTT

>54078_54078_2_MKL2-ZNF200_MKL2_chr16_14328140_ENST00000341243_ZNF200_chr16_3285360_ENST00000396868_length(amino acids)=408AA_BP=262
MEAPRNECGVWLQGMMAAKVVPMPPKPKQSFILRVPPDSKLGQDLLRDATNGPKTIHQLVLEHFLTFLPKPSLVQPSQKVKETLVIMKDV
SSSLQNRVHPRPLVKLLPKGVQKEQETVSLYLKANPELVVFEDLNVFHCQEECVSLDPTQQLTSEKEDDSSVGEMMLLAVNGSNPEGEDP
EREPVENEDYREKSSDDDEMDSSLVSQQPPDNQEKERLNTSIPQKRKMRNLLVTIENDTPLEELSKYVDISIIALTRNRRTRRWYTCPLC
GKQFNESSYLISHQRTHTGEKPYDCNHCGKSFNHKTNLNKHERIHTGEKPYSCSQCGKNFRQNSHRSRHEGIHIREKIFKCPECGKTFPK

--------------------------------------------------------------
>54078_54078_3_MKL2-ZNF200_MKL2_chr16_14328140_ENST00000571589_ZNF200_chr16_3285360_ENST00000396868_length(transcript)=4085nt_BP=1003nt
ATCGCGCGGCGGCGGCGGGAGCGGCGGCGGCGGCGGCCGGGGAGGTTCACAATAAAGGTGCTAAGAAAGAGAATGTAAGACAGGAAAATA
ATTAAATATTCTTACCGAGTGTCTTCAATAGGCCGTGTTTAAGAGGCGTCTTACACTCCCTGTTGCCAGTGGCTGGAACACAATGGATCA
CACAGGGGCGATAGACACCGAGGATGAAGTGGGACCTTTAGCCCATCTTGCTCCAAGTCCTCAGAGTGAAGCTGTGGCTCATGAATTCCA
GGAACTCTCCTTGCAGTCCAGTCAAAACTTACCCCCTCTGAACGAAAGGAAAAATGTGCTCCAGCTGAGGCTGCAACAAAGGAGGACGAG
AGAACAACTAGTGGACCAGGGCATCATGCCACCTTTGAAGAGCCCAGCGGCATTCCATGAACAGATAAAAAGCTTGGAACGAGCCAGAAC
TGAAAACTTTTTGAAACACAAGATTCGGAGTCGACCAGATCGTTCTGAACTTGTCAGGATGCACATTTTAGAAGAAACATTTGCAGAGCC
ATCCCTGCAGGCTACTCAGATGAAGTTGAAAAGAGCTCGACTAGCAGATGATCTGAATGAAAAGATTGCTCAAAGACCTGGTCCTATGGA
GCTGGTAGAGAAAAACATCCTTCCTGTGGACTCCAGTGTTAAAGAAGCAATTATAGGCGTTGGGAAGGAGGACTATCCCCACACTCAGGG
CGATTTCTCATTTGATGAAGACAGCAGTGACGCTTTGTCTCCGGACCAGCCTGCGAGTCAGGAGTCACAGGGGTCAGCCGCGTCCCCAAG
TGAGCCAAAAGTTAGTGAATCGCCATCTCCTGTGACTACAAACACTCCAGCGCAGTTTGCTTCAGTGTCCCCAACAGTTCCTGAATTCTT
GAAAACTCCTCCAACTGCAGATCAGCCTCCCCCACGGCCTGCAGCTCCTGTCCTCCCCACAAACACTGTGTCCTCAGCAAAGCCTGGCCC
AGCACTGGTGAAGGCAGAACCACAGAGAGGCTACAGCCGTCCTGGCCTCCCTCCGGCCCTGAGAGCTCCTCTGGCCTGTCTCAAGTCTTA
ACGTCTCAAGCGCAGACTGCCGGCTCCGAACGGGGAGACCAGGCTTCTGCACCGGAAACAAGGCACCGGTTGTGACGTCACAGCCGCAGA
GCGCCCGACTTCCCAGAAGGCACCGAGTCCCTGCCGTTCTCCTCAACTGGCGGCGGCGCGAACGAATAGTCGCCGGCGACCTCTTGGCTC
TCTGGCAGATTTCCTCTAGTAAGAGGTGGCTCTGGAGGCCCCGCGAAACGAGTGTGGTGTGTGGTTGCAAGGCATGATGGCTGCAAAAGT
GGTTCCTATGCCCCCAAAGCCAAAGCAGTCCTTTATACTGAGAGTTCCGCCAGACTCCAAGCTGGGCCAAGACCTACTTCGAGATGCCAC
TAACGGGCCCAAGACCATCCACCAGCTAGTGCTGGAGCACTTCCTCACCTTCTTGCCCAAGCCAAGCCTGGTCCAGCCCAGTCAGAAAGT
CAAGGAGACCTTGGTTATTATGAAAGATGTGAGCTCAAGCCTTCAGAACAGAGTGCATCCTCGTCCCTTGGTGAAGCTTCTGCCCAAAGG
AGTCCAAAAGGAACAAGAGACAGTGTCTCTGTATTTGAAAGCTAACCCTGAGCTGGTGGTCTTTGAGGATTTGAATGTATTTCACTGCCA
GGAAGAATGTGTGAGCTTGGATCCTACTCAACAACTCACGTCAGAGAAGGAAGATGACAGCAGTGTCGGGGAAATGATGTTACTGGCAGT
CAATGGCAGTAATCCTGAAGGTGAAGATCCTGAGAGGGAACCTGTAGAAAATGAAGATTATAGAGAAAAGTCTTCAGATGATGATGAAAT
GGATTCTTCCTTGGTCTCTCAGCAGCCTCCCGATAACCAGGAAAAGGAACGACTAAATACATCCATTCCACAAAAAAGGAAAATGAGAAA
TCTGTTAGTTACCATTGAGAATGATACTCCTCTAGAGGAACTCTCAAAATATGTAGACATCAGTATTATTGCCCTTACTCGAAATCGGAG
GACAAGGAGATGGTACACTTGTCCACTGTGTGGGAAACAGTTTAATGAAAGTTCTTACCTCATTTCCCACCAGAGGACCCACACTGGAGA
AAAACCCTATGACTGTAATCACTGTGGGAAAAGCTTCAATCATAAAACAAACCTCAATAAACATGAGCGAATTCATACAGGAGAGAAACC
TTATTCCTGTTCTCAGTGTGGAAAAAACTTCCGTCAGAATTCTCATCGGAGTCGTCATGAAGGAATCCATATAAGGGAGAAGATATTTAA
GTGTCCAGAATGTGGGAAAACCTTCCCAAAGAATGAGGAGTTTGTGCTTCATCTGCAGAGTCATGAGGCTGAGAGACCATATGGTTGCAA
AAAATGTGGGAGAAGATTTGGTCGGCTGTCAAACTGTACCCGGCATGAGAAAACCCACTCAGCCTGTAAGACCCGAAAGCAGAAGTAATA
CTGGGAACCCTTTCTGGGTCTGATGGTGCTGCCTCAACCTGAGAGCTTTCATAAGTAGTTCTGAATTCCCAAGCTGCCTAAAAAGGTATA
AATGTGTAAAAATCTCATTATTGCCAAAATTGGATAAATGCCCATCTTAGCTAAAACCTCAAATTGCTAGAAAATTCACAGGGAAGAAAA
CATTTCAAGGGCTATACCTCAGCATCTAGGCTTTTTGGACTAAGGAGCTTTCCTTTTTGAAGTTATATGATAATGTACAGGTCACAGATC
CCCTTTCCCAACACTTTGAAGATGAATCTGGAGTCTGCTTACTTGGAAGGCAAAGAGTGACTTGTGTCTATTGAAAGTATATCCGTTTTC
CCCCCACATGGGGATTCATACTTGAGAAATAGTGCAAAGATGCTTATCTGGAACTGTGTTCTGGTGAAAGAACCAAATTACTGGCTTGTT
AGCCAACAGCTTCTGATAGCAATTCATATAACCCTCTAAGAATACCTGTTTAAGTCTTGAGTGTTGAAAGGAATTGTTTACTTTGGAATA
TAGGAAAACAGTTGAATGTCAGACTCTCATTTGTATGTGATCTAAATTTGCAATCAATTTCAATAATATTTACAATTTGTGATAAAACTG
ACTTTTACAGATTCCTTTTCACAACATAATTTAGGTGTCTACTGTTCTTATTGTATTTTGTTCTGCTGTTGATCTCTCCAGCAGCCGTCT
CATGCTTCTCCCTTGCTAAAAGAAGTTTGGATTACTCAGGCAGGGCCATCCAGCCCCACCACTAGAAAAGCTCTTCAGAATCTTGTCCCT
CTGTTGAGCCCAGATCTCATGTGCTACGAAGGAAACCCCAAGACCCAGAGAGGAAGGGTCAACCTGGAGGCAGGAAAAAGTTGGCTTGGA
TCCATGTCTCATCAATAACCTTACCATATGCTTAGGTCCCCTCTATGCTGTCATCAGACCTTTGGCAATGGGGTGGTCACTACCTCACAA
GGCAAAGTGTTGTATGATTAGAAATTACGTCTCCAGTGGTTAGCTCACATTGCCTCTCAAGAGACAGGTTTCCAGGTGTCTTCATTGTAG
TGGGTATTAATTGTCTTCAGCCTCTTGATATCCATACCTTCCTGTCCTCTGCCTAGAAGCAAGGCCAGCGGTGCCTTTACGGACTGATCG
TGTGGTGCGATTTAGGGATTCTTCAGTTTTGCTTGCTTTAGGTTTCCAAAAGTTATACATTGGTGTTTTGATTGGAATAAAGAAATCCTA
TAAGCTATTTGGGAAAAATTATAGTGTATGTTTCCCATCCAGAAACATGCCTTTCTATTTATTAGAGTATTATATTCCTGTGAAAATTTT
TCTAATTTTCTTCACTTGTTTTACACAATTTTGTTATTGTAGTTTTTTCCATTATATTTTTATAGTTGATTATTGCTTTTACATGGGAAA
GTTATTTTTAATTATATATTTGTATAGTCATCTCACTGTTGTTAATTTTCAATAGTTTGTTGGTTTAGTTCTGTTAACTTTTGGTAAAAT

>54078_54078_3_MKL2-ZNF200_MKL2_chr16_14328140_ENST00000571589_ZNF200_chr16_3285360_ENST00000396868_length(amino acids)=408AA_BP=262
MEAPRNECGVWLQGMMAAKVVPMPPKPKQSFILRVPPDSKLGQDLLRDATNGPKTIHQLVLEHFLTFLPKPSLVQPSQKVKETLVIMKDV
SSSLQNRVHPRPLVKLLPKGVQKEQETVSLYLKANPELVVFEDLNVFHCQEECVSLDPTQQLTSEKEDDSSVGEMMLLAVNGSNPEGEDP
EREPVENEDYREKSSDDDEMDSSLVSQQPPDNQEKERLNTSIPQKRKMRNLLVTIENDTPLEELSKYVDISIIALTRNRRTRRWYTCPLC
GKQFNESSYLISHQRTHTGEKPYDCNHCGKSFNHKTNLNKHERIHTGEKPYSCSQCGKNFRQNSHRSRHEGIHIREKIFKCPECGKTFPK

--------------------------------------------------------------
>54078_54078_4_MKL2-ZNF200_MKL2_chr16_14328140_ENST00000572567_ZNF200_chr16_3285360_ENST00000396868_length(transcript)=4078nt_BP=996nt
GTATTTGCAGGTCAAGCTGGGAACTAAAGGGTAATGGCTGCCTTCAGCTGCTTAAAGACATAATTGGCCAGTGATTGGGGTATTGTGGGG
AGCAACCAGGGACCCAGGGACCAGAGTGTTCTGCGCACCGCACTTCGCTCTTCTGCAAATTAAGCTTTTCTCCTGCTTGATGCTGCCTGT
CTTCAGAAGCCTCTCACCATGATCGATAGCTCCAAGAAGCAGCAACAGGGCTTCCCAGAGATTTTAACTGCTGGGGATTTTGAACCATTA
AAAGAAAAGGAATGCCTTGAGGGGAGCAACCAGAAAAGTCTCAAGGAAGTGCTCCAGCTGAGGCTGCAACAAAGGAGGACGAGAGAACAA
CTAGTGGACCAGGGCATCATGCCACCTTTGAAGAGCCCAGCGGCATTCCATGAACAGATAAAAAGCTTGGAACGAGCCAGAACTGAAAAC
TTTTTGAAACACAAGATTCGGAGTCGACCAGATCGTTCTGAACTTGTCAGGATGCACATTTTAGAAGAAACATTTGCAGAGCCATCCCTG
CAGGCTACTCAGATGAAGTTGAAAAGAGCTCGACTAGCAGATGATCTGAATGAAAAGATTGCTCAAAGACCTGGTCCTATGGAGCTGGTA
GAGAAAAACATCCTTCCTGTGGACTCCAGTGTTAAAGAAGCAATTATAGGCGTTGGGAAGGAGGACTATCCCCACACTCAGGGCGATTTC
TCATTTGATGAAGACAGCAGTGACGCTTTGTCTCCGGACCAGCCTGCGAGTCAGGAGTCACAGGGGTCAGCCGCGTCCCCAAGTGAGCCA
AAAGTTAGTGAATCGCCATCTCCTGTGACTACAAACACTCCAGCGCAGTTTGCTTCAGTGTCCCCAACAGTTCCTGAATTCTTGAAAACT
CCTCCAACTGCAGATCAGCCTCCCCCACGGCCTGCAGCTCCTGTCCTCCCCACAAACACTGTGTCCTCAGCAAAGCCTGGCCCAGCACTG
GTGAAGGCAGAACCACAGAGAGGCTACAGCCGTCCTGGCCTCCCTCCGGCCCTGAGAGCTCCTCTGGCCTGTCTCAAGTCTTAACGTCTC
AAGCGCAGACTGCCGGCTCCGAACGGGGAGACCAGGCTTCTGCACCGGAAACAAGGCACCGGTTGTGACGTCACAGCCGCAGAGCGCCCG
ACTTCCCAGAAGGCACCGAGTCCCTGCCGTTCTCCTCAACTGGCGGCGGCGCGAACGAATAGTCGCCGGCGACCTCTTGGCTCTCTGGCA
GATTTCCTCTAGTAAGAGGTGGCTCTGGAGGCCCCGCGAAACGAGTGTGGTGTGTGGTTGCAAGGCATGATGGCTGCAAAAGTGGTTCCT
ATGCCCCCAAAGCCAAAGCAGTCCTTTATACTGAGAGTTCCGCCAGACTCCAAGCTGGGCCAAGACCTACTTCGAGATGCCACTAACGGG
CCCAAGACCATCCACCAGCTAGTGCTGGAGCACTTCCTCACCTTCTTGCCCAAGCCAAGCCTGGTCCAGCCCAGTCAGAAAGTCAAGGAG
ACCTTGGTTATTATGAAAGATGTGAGCTCAAGCCTTCAGAACAGAGTGCATCCTCGTCCCTTGGTGAAGCTTCTGCCCAAAGGAGTCCAA
AAGGAACAAGAGACAGTGTCTCTGTATTTGAAAGCTAACCCTGAGCTGGTGGTCTTTGAGGATTTGAATGTATTTCACTGCCAGGAAGAA
TGTGTGAGCTTGGATCCTACTCAACAACTCACGTCAGAGAAGGAAGATGACAGCAGTGTCGGGGAAATGATGTTACTGGCAGTCAATGGC
AGTAATCCTGAAGGTGAAGATCCTGAGAGGGAACCTGTAGAAAATGAAGATTATAGAGAAAAGTCTTCAGATGATGATGAAATGGATTCT
TCCTTGGTCTCTCAGCAGCCTCCCGATAACCAGGAAAAGGAACGACTAAATACATCCATTCCACAAAAAAGGAAAATGAGAAATCTGTTA
GTTACCATTGAGAATGATACTCCTCTAGAGGAACTCTCAAAATATGTAGACATCAGTATTATTGCCCTTACTCGAAATCGGAGGACAAGG
AGATGGTACACTTGTCCACTGTGTGGGAAACAGTTTAATGAAAGTTCTTACCTCATTTCCCACCAGAGGACCCACACTGGAGAAAAACCC
TATGACTGTAATCACTGTGGGAAAAGCTTCAATCATAAAACAAACCTCAATAAACATGAGCGAATTCATACAGGAGAGAAACCTTATTCC
TGTTCTCAGTGTGGAAAAAACTTCCGTCAGAATTCTCATCGGAGTCGTCATGAAGGAATCCATATAAGGGAGAAGATATTTAAGTGTCCA
GAATGTGGGAAAACCTTCCCAAAGAATGAGGAGTTTGTGCTTCATCTGCAGAGTCATGAGGCTGAGAGACCATATGGTTGCAAAAAATGT
GGGAGAAGATTTGGTCGGCTGTCAAACTGTACCCGGCATGAGAAAACCCACTCAGCCTGTAAGACCCGAAAGCAGAAGTAATACTGGGAA
CCCTTTCTGGGTCTGATGGTGCTGCCTCAACCTGAGAGCTTTCATAAGTAGTTCTGAATTCCCAAGCTGCCTAAAAAGGTATAAATGTGT
AAAAATCTCATTATTGCCAAAATTGGATAAATGCCCATCTTAGCTAAAACCTCAAATTGCTAGAAAATTCACAGGGAAGAAAACATTTCA
AGGGCTATACCTCAGCATCTAGGCTTTTTGGACTAAGGAGCTTTCCTTTTTGAAGTTATATGATAATGTACAGGTCACAGATCCCCTTTC
CCAACACTTTGAAGATGAATCTGGAGTCTGCTTACTTGGAAGGCAAAGAGTGACTTGTGTCTATTGAAAGTATATCCGTTTTCCCCCCAC
ATGGGGATTCATACTTGAGAAATAGTGCAAAGATGCTTATCTGGAACTGTGTTCTGGTGAAAGAACCAAATTACTGGCTTGTTAGCCAAC
AGCTTCTGATAGCAATTCATATAACCCTCTAAGAATACCTGTTTAAGTCTTGAGTGTTGAAAGGAATTGTTTACTTTGGAATATAGGAAA
ACAGTTGAATGTCAGACTCTCATTTGTATGTGATCTAAATTTGCAATCAATTTCAATAATATTTACAATTTGTGATAAAACTGACTTTTA
CAGATTCCTTTTCACAACATAATTTAGGTGTCTACTGTTCTTATTGTATTTTGTTCTGCTGTTGATCTCTCCAGCAGCCGTCTCATGCTT
CTCCCTTGCTAAAAGAAGTTTGGATTACTCAGGCAGGGCCATCCAGCCCCACCACTAGAAAAGCTCTTCAGAATCTTGTCCCTCTGTTGA
GCCCAGATCTCATGTGCTACGAAGGAAACCCCAAGACCCAGAGAGGAAGGGTCAACCTGGAGGCAGGAAAAAGTTGGCTTGGATCCATGT
CTCATCAATAACCTTACCATATGCTTAGGTCCCCTCTATGCTGTCATCAGACCTTTGGCAATGGGGTGGTCACTACCTCACAAGGCAAAG
TGTTGTATGATTAGAAATTACGTCTCCAGTGGTTAGCTCACATTGCCTCTCAAGAGACAGGTTTCCAGGTGTCTTCATTGTAGTGGGTAT
TAATTGTCTTCAGCCTCTTGATATCCATACCTTCCTGTCCTCTGCCTAGAAGCAAGGCCAGCGGTGCCTTTACGGACTGATCGTGTGGTG
CGATTTAGGGATTCTTCAGTTTTGCTTGCTTTAGGTTTCCAAAAGTTATACATTGGTGTTTTGATTGGAATAAAGAAATCCTATAAGCTA
TTTGGGAAAAATTATAGTGTATGTTTCCCATCCAGAAACATGCCTTTCTATTTATTAGAGTATTATATTCCTGTGAAAATTTTTCTAATT
TTCTTCACTTGTTTTACACAATTTTGTTATTGTAGTTTTTTCCATTATATTTTTATAGTTGATTATTGCTTTTACATGGGAAAGTTATTT
TTAATTATATATTTGTATAGTCATCTCACTGTTGTTAATTTTCAATAGTTTGTTGGTTTAGTTCTGTTAACTTTTGGTAAAATGACACCA

>54078_54078_4_MKL2-ZNF200_MKL2_chr16_14328140_ENST00000572567_ZNF200_chr16_3285360_ENST00000396868_length(amino acids)=408AA_BP=262
MEAPRNECGVWLQGMMAAKVVPMPPKPKQSFILRVPPDSKLGQDLLRDATNGPKTIHQLVLEHFLTFLPKPSLVQPSQKVKETLVIMKDV
SSSLQNRVHPRPLVKLLPKGVQKEQETVSLYLKANPELVVFEDLNVFHCQEECVSLDPTQQLTSEKEDDSSVGEMMLLAVNGSNPEGEDP
EREPVENEDYREKSSDDDEMDSSLVSQQPPDNQEKERLNTSIPQKRKMRNLLVTIENDTPLEELSKYVDISIIALTRNRRTRRWYTCPLC
GKQFNESSYLISHQRTHTGEKPYDCNHCGKSFNHKTNLNKHERIHTGEKPYSCSQCGKNFRQNSHRSRHEGIHIREKIFKCPECGKTFPK

--------------------------------------------------------------
>54078_54078_5_MKL2-ZNF200_MKL2_chr16_14328140_ENST00000573051_ZNF200_chr16_3285360_ENST00000396868_length(transcript)=3918nt_BP=836nt
CGGAAGTAAGGCTGGCGTAGGGCCGCCATGTTGCAGCAGGATAGTAATGATGACACTAAAGATGTTTCACTGTTTGATGCGGAAGAGGAG
ACGACTAATAGACCAAGAAAAGTCAAAATCAGACATCCAGTAGCATCGTTTTTCCACTTATTCTTTCGATGCTCCAGCTGAGGCTGCAAC
AAAGGAGGACGAGAGAACAACTAGTGGACCAGGGCATCATGCCACCTTTGAAGAGCCCAGCGGCATTCCATGAACAGATAAAAAGCTTGG
AACGAGCCAGAACTGAAAACTTTTTGAAACACAAGATTCGGAGTCGACCAGATCGTTCTGAACTTGTCAGGATGCACATTTTAGAAGAAA
CATTTGCAGAGCCATCCCTGCAGGCTACTCAGATGAAGTTGAAAAGAGCTCGACTAGCAGATGATCTGAATGAAAAGATTGCTCAAAGAC
CTGGTCCTATGGAGCTGGTAGAGAAAAACATCCTTCCTGTGGACTCCAGTGTTAAAGAAGCAATTATAGGCGTTGGGAAGGAGGACTATC
CCCACACTCAGGGCGATTTCTCATTTGATGAAGACAGCAGTGACGCTTTGTCTCCGGACCAGCCTGCGAGTCAGGAGTCACAGGGGTCAG
CCGCGTCCCCAAGTGAGCCAAAAGTTAGTGAATCGCCATCTCCTGTGACTACAAACACTCCAGCGCAGTTTGCTTCAGTGTCCCCAACAG
TTCCTGAATTCTTGAAAACTCCTCCAACTGCAGATCAGCCTCCCCCACGGCCTGCAGCTCCTGTCCTCCCCACAAACACTGTGTCCTCAG
CAAAGCCTGGCCCAGCACTGGTGAAGGCAGAACCACAGAGAGGCTACAGCCGTCCTGGCCTCCCTCCGGCCCTGAGAGCTCCTCTGGCCT
GTCTCAAGTCTTAACGTCTCAAGCGCAGACTGCCGGCTCCGAACGGGGAGACCAGGCTTCTGCACCGGAAACAAGGCACCGGTTGTGACG
TCACAGCCGCAGAGCGCCCGACTTCCCAGAAGGCACCGAGTCCCTGCCGTTCTCCTCAACTGGCGGCGGCGCGAACGAATAGTCGCCGGC
GACCTCTTGGCTCTCTGGCAGATTTCCTCTAGTAAGAGGTGGCTCTGGAGGCCCCGCGAAACGAGTGTGGTGTGTGGTTGCAAGGCATGA
TGGCTGCAAAAGTGGTTCCTATGCCCCCAAAGCCAAAGCAGTCCTTTATACTGAGAGTTCCGCCAGACTCCAAGCTGGGCCAAGACCTAC
TTCGAGATGCCACTAACGGGCCCAAGACCATCCACCAGCTAGTGCTGGAGCACTTCCTCACCTTCTTGCCCAAGCCAAGCCTGGTCCAGC
CCAGTCAGAAAGTCAAGGAGACCTTGGTTATTATGAAAGATGTGAGCTCAAGCCTTCAGAACAGAGTGCATCCTCGTCCCTTGGTGAAGC
TTCTGCCCAAAGGAGTCCAAAAGGAACAAGAGACAGTGTCTCTGTATTTGAAAGCTAACCCTGAGCTGGTGGTCTTTGAGGATTTGAATG
TATTTCACTGCCAGGAAGAATGTGTGAGCTTGGATCCTACTCAACAACTCACGTCAGAGAAGGAAGATGACAGCAGTGTCGGGGAAATGA
TGTTACTGGCAGTCAATGGCAGTAATCCTGAAGGTGAAGATCCTGAGAGGGAACCTGTAGAAAATGAAGATTATAGAGAAAAGTCTTCAG
ATGATGATGAAATGGATTCTTCCTTGGTCTCTCAGCAGCCTCCCGATAACCAGGAAAAGGAACGACTAAATACATCCATTCCACAAAAAA
GGAAAATGAGAAATCTGTTAGTTACCATTGAGAATGATACTCCTCTAGAGGAACTCTCAAAATATGTAGACATCAGTATTATTGCCCTTA
CTCGAAATCGGAGGACAAGGAGATGGTACACTTGTCCACTGTGTGGGAAACAGTTTAATGAAAGTTCTTACCTCATTTCCCACCAGAGGA
CCCACACTGGAGAAAAACCCTATGACTGTAATCACTGTGGGAAAAGCTTCAATCATAAAACAAACCTCAATAAACATGAGCGAATTCATA
CAGGAGAGAAACCTTATTCCTGTTCTCAGTGTGGAAAAAACTTCCGTCAGAATTCTCATCGGAGTCGTCATGAAGGAATCCATATAAGGG
AGAAGATATTTAAGTGTCCAGAATGTGGGAAAACCTTCCCAAAGAATGAGGAGTTTGTGCTTCATCTGCAGAGTCATGAGGCTGAGAGAC
CATATGGTTGCAAAAAATGTGGGAGAAGATTTGGTCGGCTGTCAAACTGTACCCGGCATGAGAAAACCCACTCAGCCTGTAAGACCCGAA
AGCAGAAGTAATACTGGGAACCCTTTCTGGGTCTGATGGTGCTGCCTCAACCTGAGAGCTTTCATAAGTAGTTCTGAATTCCCAAGCTGC
CTAAAAAGGTATAAATGTGTAAAAATCTCATTATTGCCAAAATTGGATAAATGCCCATCTTAGCTAAAACCTCAAATTGCTAGAAAATTC
ACAGGGAAGAAAACATTTCAAGGGCTATACCTCAGCATCTAGGCTTTTTGGACTAAGGAGCTTTCCTTTTTGAAGTTATATGATAATGTA
CAGGTCACAGATCCCCTTTCCCAACACTTTGAAGATGAATCTGGAGTCTGCTTACTTGGAAGGCAAAGAGTGACTTGTGTCTATTGAAAG
TATATCCGTTTTCCCCCCACATGGGGATTCATACTTGAGAAATAGTGCAAAGATGCTTATCTGGAACTGTGTTCTGGTGAAAGAACCAAA
TTACTGGCTTGTTAGCCAACAGCTTCTGATAGCAATTCATATAACCCTCTAAGAATACCTGTTTAAGTCTTGAGTGTTGAAAGGAATTGT
TTACTTTGGAATATAGGAAAACAGTTGAATGTCAGACTCTCATTTGTATGTGATCTAAATTTGCAATCAATTTCAATAATATTTACAATT
TGTGATAAAACTGACTTTTACAGATTCCTTTTCACAACATAATTTAGGTGTCTACTGTTCTTATTGTATTTTGTTCTGCTGTTGATCTCT
CCAGCAGCCGTCTCATGCTTCTCCCTTGCTAAAAGAAGTTTGGATTACTCAGGCAGGGCCATCCAGCCCCACCACTAGAAAAGCTCTTCA
GAATCTTGTCCCTCTGTTGAGCCCAGATCTCATGTGCTACGAAGGAAACCCCAAGACCCAGAGAGGAAGGGTCAACCTGGAGGCAGGAAA
AAGTTGGCTTGGATCCATGTCTCATCAATAACCTTACCATATGCTTAGGTCCCCTCTATGCTGTCATCAGACCTTTGGCAATGGGGTGGT
CACTACCTCACAAGGCAAAGTGTTGTATGATTAGAAATTACGTCTCCAGTGGTTAGCTCACATTGCCTCTCAAGAGACAGGTTTCCAGGT
GTCTTCATTGTAGTGGGTATTAATTGTCTTCAGCCTCTTGATATCCATACCTTCCTGTCCTCTGCCTAGAAGCAAGGCCAGCGGTGCCTT
TACGGACTGATCGTGTGGTGCGATTTAGGGATTCTTCAGTTTTGCTTGCTTTAGGTTTCCAAAAGTTATACATTGGTGTTTTGATTGGAA
TAAAGAAATCCTATAAGCTATTTGGGAAAAATTATAGTGTATGTTTCCCATCCAGAAACATGCCTTTCTATTTATTAGAGTATTATATTC
CTGTGAAAATTTTTCTAATTTTCTTCACTTGTTTTACACAATTTTGTTATTGTAGTTTTTTCCATTATATTTTTATAGTTGATTATTGCT
TTTACATGGGAAAGTTATTTTTAATTATATATTTGTATAGTCATCTCACTGTTGTTAATTTTCAATAGTTTGTTGGTTTAGTTCTGTTAA

>54078_54078_5_MKL2-ZNF200_MKL2_chr16_14328140_ENST00000573051_ZNF200_chr16_3285360_ENST00000396868_length(amino acids)=408AA_BP=262
MEAPRNECGVWLQGMMAAKVVPMPPKPKQSFILRVPPDSKLGQDLLRDATNGPKTIHQLVLEHFLTFLPKPSLVQPSQKVKETLVIMKDV
SSSLQNRVHPRPLVKLLPKGVQKEQETVSLYLKANPELVVFEDLNVFHCQEECVSLDPTQQLTSEKEDDSSVGEMMLLAVNGSNPEGEDP
EREPVENEDYREKSSDDDEMDSSLVSQQPPDNQEKERLNTSIPQKRKMRNLLVTIENDTPLEELSKYVDISIIALTRNRRTRRWYTCPLC
GKQFNESSYLISHQRTHTGEKPYDCNHCGKSFNHKTNLNKHERIHTGEKPYSCSQCGKNFRQNSHRSRHEGIHIREKIFKCPECGKTFPK

--------------------------------------------------------------
>54078_54078_6_MKL2-ZNF200_MKL2_chr16_14328140_ENST00000574045_ZNF200_chr16_3285360_ENST00000396868_length(transcript)=4068nt_BP=986nt
GGAGCGGCGGCGGCGGCGGCCGGGGAGGTTCACAATAAAGGTGCTAAGAAAGAGAATGTAAGACAGGAAAATAATTAAATATTCTTACCG
AGTGTCTTCAATAGGCCGTGTTTAAGAGGCGTCTTACACTCCCTGTTGCCAGTGGCTGGAACACAATGGATCACACAGGGGCGATAGACA
CCGAGGATGAAGTGGGACCTTTAGCCCATCTTGCTCCAAGTCCTCAGAGTGAAGCTGTGGCTCATGAATTCCAGGAACTCTCCTTGCAGT
CCAGTCAAAACTTACCCCCTCTGAACGAAAGGAAAAATGTGCTCCAGCTGAGGCTGCAACAAAGGAGGACGAGAGAACAACTAGTGGACC
AGGGCATCATGCCACCTTTGAAGAGCCCAGCGGCATTCCATGAACAGATAAAAAGCTTGGAACGAGCCAGAACTGAAAACTTTTTGAAAC
ACAAGATTCGGAGTCGACCAGATCGTTCTGAACTTGTCAGGATGCACATTTTAGAAGAAACATTTGCAGAGCCATCCCTGCAGGCTACTC
AGATGAAGTTGAAAAGAGCTCGACTAGCAGATGATCTGAATGAAAAGATTGCTCAAAGACCTGGTCCTATGGAGCTGGTAGAGAAAAACA
TCCTTCCTGTGGACTCCAGTGTTAAAGAAGCAATTATAGGCGTTGGGAAGGAGGACTATCCCCACACTCAGGGCGATTTCTCATTTGATG
AAGACAGCAGTGACGCTTTGTCTCCGGACCAGCCTGCGAGTCAGGAGTCACAGGGGTCAGCCGCGTCCCCAAGTGAGCCAAAAGTTAGTG
AATCGCCATCTCCTGTGACTACAAACACTCCAGCGCAGTTTGCTTCAGTGTCCCCAACAGTTCCTGAATTCTTGAAAACTCCTCCAACTG
CAGATCAGCCTCCCCCACGGCCTGCAGCTCCTGTCCTCCCCACAAACACTGTGTCCTCAGCAAAGCCTGGCCCAGCACTGGTGAAGGCAG
AACCACAGAGAGGCTACAGCCGTCCTGGCCTCCCTCCGGCCCTGAGAGCTCCTCTGGCCTGTCTCAAGTCTTAACGTCTCAAGCGCAGAC
TGCCGGCTCCGAACGGGGAGACCAGGCTTCTGCACCGGAAACAAGGCACCGGTTGTGACGTCACAGCCGCAGAGCGCCCGACTTCCCAGA
AGGCACCGAGTCCCTGCCGTTCTCCTCAACTGGCGGCGGCGCGAACGAATAGTCGCCGGCGACCTCTTGGCTCTCTGGCAGATTTCCTCT
AGTAAGAGGTGGCTCTGGAGGCCCCGCGAAACGAGTGTGGTGTGTGGTTGCAAGGCATGATGGCTGCAAAAGTGGTTCCTATGCCCCCAA
AGCCAAAGCAGTCCTTTATACTGAGAGTTCCGCCAGACTCCAAGCTGGGCCAAGACCTACTTCGAGATGCCACTAACGGGCCCAAGACCA
TCCACCAGCTAGTGCTGGAGCACTTCCTCACCTTCTTGCCCAAGCCAAGCCTGGTCCAGCCCAGTCAGAAAGTCAAGGAGACCTTGGTTA
TTATGAAAGATGTGAGCTCAAGCCTTCAGAACAGAGTGCATCCTCGTCCCTTGGTGAAGCTTCTGCCCAAAGGAGTCCAAAAGGAACAAG
AGACAGTGTCTCTGTATTTGAAAGCTAACCCTGAGCTGGTGGTCTTTGAGGATTTGAATGTATTTCACTGCCAGGAAGAATGTGTGAGCT
TGGATCCTACTCAACAACTCACGTCAGAGAAGGAAGATGACAGCAGTGTCGGGGAAATGATGTTACTGGCAGTCAATGGCAGTAATCCTG
AAGGTGAAGATCCTGAGAGGGAACCTGTAGAAAATGAAGATTATAGAGAAAAGTCTTCAGATGATGATGAAATGGATTCTTCCTTGGTCT
CTCAGCAGCCTCCCGATAACCAGGAAAAGGAACGACTAAATACATCCATTCCACAAAAAAGGAAAATGAGAAATCTGTTAGTTACCATTG
AGAATGATACTCCTCTAGAGGAACTCTCAAAATATGTAGACATCAGTATTATTGCCCTTACTCGAAATCGGAGGACAAGGAGATGGTACA
CTTGTCCACTGTGTGGGAAACAGTTTAATGAAAGTTCTTACCTCATTTCCCACCAGAGGACCCACACTGGAGAAAAACCCTATGACTGTA
ATCACTGTGGGAAAAGCTTCAATCATAAAACAAACCTCAATAAACATGAGCGAATTCATACAGGAGAGAAACCTTATTCCTGTTCTCAGT
GTGGAAAAAACTTCCGTCAGAATTCTCATCGGAGTCGTCATGAAGGAATCCATATAAGGGAGAAGATATTTAAGTGTCCAGAATGTGGGA
AAACCTTCCCAAAGAATGAGGAGTTTGTGCTTCATCTGCAGAGTCATGAGGCTGAGAGACCATATGGTTGCAAAAAATGTGGGAGAAGAT
TTGGTCGGCTGTCAAACTGTACCCGGCATGAGAAAACCCACTCAGCCTGTAAGACCCGAAAGCAGAAGTAATACTGGGAACCCTTTCTGG
GTCTGATGGTGCTGCCTCAACCTGAGAGCTTTCATAAGTAGTTCTGAATTCCCAAGCTGCCTAAAAAGGTATAAATGTGTAAAAATCTCA
TTATTGCCAAAATTGGATAAATGCCCATCTTAGCTAAAACCTCAAATTGCTAGAAAATTCACAGGGAAGAAAACATTTCAAGGGCTATAC
CTCAGCATCTAGGCTTTTTGGACTAAGGAGCTTTCCTTTTTGAAGTTATATGATAATGTACAGGTCACAGATCCCCTTTCCCAACACTTT
GAAGATGAATCTGGAGTCTGCTTACTTGGAAGGCAAAGAGTGACTTGTGTCTATTGAAAGTATATCCGTTTTCCCCCCACATGGGGATTC
ATACTTGAGAAATAGTGCAAAGATGCTTATCTGGAACTGTGTTCTGGTGAAAGAACCAAATTACTGGCTTGTTAGCCAACAGCTTCTGAT
AGCAATTCATATAACCCTCTAAGAATACCTGTTTAAGTCTTGAGTGTTGAAAGGAATTGTTTACTTTGGAATATAGGAAAACAGTTGAAT
GTCAGACTCTCATTTGTATGTGATCTAAATTTGCAATCAATTTCAATAATATTTACAATTTGTGATAAAACTGACTTTTACAGATTCCTT
TTCACAACATAATTTAGGTGTCTACTGTTCTTATTGTATTTTGTTCTGCTGTTGATCTCTCCAGCAGCCGTCTCATGCTTCTCCCTTGCT
AAAAGAAGTTTGGATTACTCAGGCAGGGCCATCCAGCCCCACCACTAGAAAAGCTCTTCAGAATCTTGTCCCTCTGTTGAGCCCAGATCT
CATGTGCTACGAAGGAAACCCCAAGACCCAGAGAGGAAGGGTCAACCTGGAGGCAGGAAAAAGTTGGCTTGGATCCATGTCTCATCAATA
ACCTTACCATATGCTTAGGTCCCCTCTATGCTGTCATCAGACCTTTGGCAATGGGGTGGTCACTACCTCACAAGGCAAAGTGTTGTATGA
TTAGAAATTACGTCTCCAGTGGTTAGCTCACATTGCCTCTCAAGAGACAGGTTTCCAGGTGTCTTCATTGTAGTGGGTATTAATTGTCTT
CAGCCTCTTGATATCCATACCTTCCTGTCCTCTGCCTAGAAGCAAGGCCAGCGGTGCCTTTACGGACTGATCGTGTGGTGCGATTTAGGG
ATTCTTCAGTTTTGCTTGCTTTAGGTTTCCAAAAGTTATACATTGGTGTTTTGATTGGAATAAAGAAATCCTATAAGCTATTTGGGAAAA
ATTATAGTGTATGTTTCCCATCCAGAAACATGCCTTTCTATTTATTAGAGTATTATATTCCTGTGAAAATTTTTCTAATTTTCTTCACTT
GTTTTACACAATTTTGTTATTGTAGTTTTTTCCATTATATTTTTATAGTTGATTATTGCTTTTACATGGGAAAGTTATTTTTAATTATAT
ATTTGTATAGTCATCTCACTGTTGTTAATTTTCAATAGTTTGTTGGTTTAGTTCTGTTAACTTTTGGTAAAATGACACCATCTACAAAGA

>54078_54078_6_MKL2-ZNF200_MKL2_chr16_14328140_ENST00000574045_ZNF200_chr16_3285360_ENST00000396868_length(amino acids)=408AA_BP=262
MEAPRNECGVWLQGMMAAKVVPMPPKPKQSFILRVPPDSKLGQDLLRDATNGPKTIHQLVLEHFLTFLPKPSLVQPSQKVKETLVIMKDV
SSSLQNRVHPRPLVKLLPKGVQKEQETVSLYLKANPELVVFEDLNVFHCQEECVSLDPTQQLTSEKEDDSSVGEMMLLAVNGSNPEGEDP
EREPVENEDYREKSSDDDEMDSSLVSQQPPDNQEKERLNTSIPQKRKMRNLLVTIENDTPLEELSKYVDISIIALTRNRRTRRWYTCPLC
GKQFNESSYLISHQRTHTGEKPYDCNHCGKSFNHKTNLNKHERIHTGEKPYSCSQCGKNFRQNSHRSRHEGIHIREKIFKCPECGKTFPK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MKL2-ZNF200


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MKL2-ZNF200


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MKL2-ZNF200


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource