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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MKNK1-ATPAF1 (FusionGDB2 ID:54095)

Fusion Gene Summary for MKNK1-ATPAF1

Fusion gene summary

Fusion gene information	Fusion gene name: MKNK1-ATPAF1
	Fusion gene ID: 54095
		Hgene	Tgene
	Gene symbol	MKNK1	ATPAF1
	Gene ID	8569	64756
	Gene name	MAPK interacting serine/threonine kinase 1	ATP synthase mitochondrial F1 complex assembly factor 1
	Synonyms	MNK1	ATP11\|ATP11p
	Cytomap	1p33	1p33
	Type of gene	protein-coding	protein-coding
	Description	MAP kinase-interacting serine/threonine-protein kinase 1MAP kinase interacting serine/threonine kinase 1MAP kinase signal-integrating kinase 1MAPK signal-integrating kinase 1	ATP synthase mitochondrial F1 complex assembly factor 1homolog of yeast ATP11
	Modification date	20200327	20200313
	UniProtAcc	Q9BUB5	Q5TC12
	Ensembl transtripts involved in fusion gene	ENST00000341183, ENST00000371945, ENST00000371946, ENST00000428112, ENST00000465783, ENST00000545730, ENST00000525888, ENST00000371944,	ENST00000329231, ENST00000371937, ENST00000525633, ENST00000532925, ENST00000542495, ENST00000574428, ENST00000576409,
Fusion gene scores	* DoF score	3 X 5 X 4=60	6 X 8 X 3=144
	# samples	5	8
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MKNK1 [Title/Abstract] AND ATPAF1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MKNK1(47059784)-ATPAF1(47110928), # samples:1 MKNK1(47069899)-ATPAF1(47118300), # samples:1 MKNK1(47069857)-ATPAF1(47118300), # samples:1 MKNK1(47082383)-ATPAF1(47131036), # samples:1
Anticipated loss of major functional domain due to fusion event.	MKNK1-ATPAF1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. MKNK1-ATPAF1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. MKNK1-ATPAF1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MKNK1	GO:0006468	protein phosphorylation	9155018
Hgene	MKNK1	GO:0018105	peptidyl-serine phosphorylation	17130135
Hgene	MKNK1	GO:0035556	intracellular signal transduction	9155018

Fusion gene breakpoints across MKNK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATPAF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-55-8506-01A	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
ChimerDB4	LUAD	TCGA-55-8506-01A	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
ChimerDB4	OV	TCGA-13-0893-01B	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
ChimerDB4	OV	TCGA-24-1428	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-

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Fusion Gene ORF analysis for MKNK1-ATPAF1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000341183	ENST00000329231	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000341183	ENST00000371937	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000341183	ENST00000525633	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000341183	ENST00000532925	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000341183	ENST00000542495	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000341183	ENST00000574428	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000371945	ENST00000329231	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000371945	ENST00000371937	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000371945	ENST00000525633	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000371945	ENST00000532925	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000371945	ENST00000542495	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000371945	ENST00000574428	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000371946	ENST00000329231	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000371946	ENST00000371937	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000371946	ENST00000525633	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000371946	ENST00000532925	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000371946	ENST00000542495	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000371946	ENST00000574428	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000428112	ENST00000329231	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000428112	ENST00000371937	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000428112	ENST00000525633	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000428112	ENST00000532925	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000428112	ENST00000542495	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000428112	ENST00000574428	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000465783	ENST00000329231	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000465783	ENST00000371937	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000465783	ENST00000525633	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000465783	ENST00000532925	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000465783	ENST00000542495	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000465783	ENST00000574428	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000545730	ENST00000329231	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000545730	ENST00000371937	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000545730	ENST00000525633	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000545730	ENST00000532925	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000545730	ENST00000542495	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5CDS-intron	ENST00000545730	ENST00000574428	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5UTR-3CDS	ENST00000341183	ENST00000329231	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000341183	ENST00000371937	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000341183	ENST00000532925	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000341183	ENST00000542495	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000341183	ENST00000574428	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000341183	ENST00000576409	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000371945	ENST00000329231	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000371945	ENST00000371937	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000371945	ENST00000532925	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000371945	ENST00000542495	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000371945	ENST00000574428	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000371945	ENST00000576409	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000371946	ENST00000329231	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000371946	ENST00000371937	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000371946	ENST00000532925	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000371946	ENST00000542495	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000371946	ENST00000574428	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000371946	ENST00000576409	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000428112	ENST00000329231	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000428112	ENST00000371937	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000428112	ENST00000532925	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000428112	ENST00000542495	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000428112	ENST00000574428	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000428112	ENST00000576409	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000525888	ENST00000329231	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000525888	ENST00000371937	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000525888	ENST00000532925	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000525888	ENST00000542495	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000525888	ENST00000574428	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000525888	ENST00000576409	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-3CDS	ENST00000525888	ENST00000576409	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5UTR-3CDS	ENST00000545730	ENST00000371937	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
5UTR-3CDS	ENST00000545730	ENST00000574428	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
5UTR-3CDS	ENST00000545730	ENST00000576409	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
5UTR-5UTR	ENST00000545730	ENST00000329231	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
5UTR-5UTR	ENST00000545730	ENST00000525633	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
5UTR-5UTR	ENST00000545730	ENST00000532925	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
5UTR-5UTR	ENST00000545730	ENST00000542495	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
5UTR-intron	ENST00000341183	ENST00000525633	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-intron	ENST00000371945	ENST00000525633	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-intron	ENST00000371946	ENST00000525633	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-intron	ENST00000428112	ENST00000525633	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
5UTR-intron	ENST00000525888	ENST00000329231	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5UTR-intron	ENST00000525888	ENST00000371937	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5UTR-intron	ENST00000525888	ENST00000525633	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
5UTR-intron	ENST00000525888	ENST00000525633	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5UTR-intron	ENST00000525888	ENST00000532925	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5UTR-intron	ENST00000525888	ENST00000542495	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
5UTR-intron	ENST00000525888	ENST00000574428	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
Frame-shift	ENST00000545730	ENST00000576409	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
In-frame	ENST00000341183	ENST00000576409	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
In-frame	ENST00000371945	ENST00000576409	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
In-frame	ENST00000371946	ENST00000576409	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
In-frame	ENST00000428112	ENST00000576409	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
In-frame	ENST00000465783	ENST00000576409	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
intron-3CDS	ENST00000341183	ENST00000329231	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000341183	ENST00000371937	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000341183	ENST00000371937	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000341183	ENST00000532925	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000341183	ENST00000542495	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000341183	ENST00000574428	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000341183	ENST00000574428	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000341183	ENST00000576409	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000341183	ENST00000576409	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000371944	ENST00000329231	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371944	ENST00000329231	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371944	ENST00000371937	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371944	ENST00000371937	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371944	ENST00000371937	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000371944	ENST00000532925	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371944	ENST00000532925	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371944	ENST00000542495	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371944	ENST00000542495	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371944	ENST00000574428	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371944	ENST00000574428	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371944	ENST00000574428	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000371944	ENST00000576409	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371944	ENST00000576409	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371944	ENST00000576409	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000371944	ENST00000576409	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
intron-3CDS	ENST00000371945	ENST00000329231	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371945	ENST00000371937	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371945	ENST00000371937	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000371945	ENST00000532925	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371945	ENST00000542495	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371945	ENST00000574428	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371945	ENST00000574428	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000371945	ENST00000576409	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371945	ENST00000576409	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000371946	ENST00000329231	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371946	ENST00000371937	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371946	ENST00000371937	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000371946	ENST00000532925	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371946	ENST00000542495	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371946	ENST00000574428	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371946	ENST00000574428	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000371946	ENST00000576409	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000371946	ENST00000576409	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000428112	ENST00000329231	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000428112	ENST00000371937	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000428112	ENST00000371937	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000428112	ENST00000532925	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000428112	ENST00000542495	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000428112	ENST00000574428	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000428112	ENST00000574428	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000428112	ENST00000576409	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000428112	ENST00000576409	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000465783	ENST00000329231	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000465783	ENST00000329231	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000465783	ENST00000371937	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000465783	ENST00000371937	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000465783	ENST00000371937	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000465783	ENST00000532925	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000465783	ENST00000532925	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000465783	ENST00000542495	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000465783	ENST00000542495	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000465783	ENST00000574428	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000465783	ENST00000574428	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000465783	ENST00000574428	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000465783	ENST00000576409	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000465783	ENST00000576409	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000465783	ENST00000576409	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000525888	ENST00000329231	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000525888	ENST00000371937	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000525888	ENST00000371937	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000525888	ENST00000532925	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000525888	ENST00000542495	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000525888	ENST00000574428	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000525888	ENST00000574428	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000525888	ENST00000576409	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000525888	ENST00000576409	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-3CDS	ENST00000545730	ENST00000329231	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000545730	ENST00000329231	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000545730	ENST00000371937	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000545730	ENST00000371937	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000545730	ENST00000532925	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000545730	ENST00000532925	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000545730	ENST00000542495	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000545730	ENST00000542495	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000545730	ENST00000574428	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000545730	ENST00000574428	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000545730	ENST00000576409	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-3CDS	ENST00000545730	ENST00000576409	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-5UTR	ENST00000341183	ENST00000329231	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000341183	ENST00000525633	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000341183	ENST00000532925	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000341183	ENST00000542495	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000371944	ENST00000329231	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000371944	ENST00000525633	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000371944	ENST00000532925	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000371944	ENST00000542495	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000371945	ENST00000329231	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000371945	ENST00000525633	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000371945	ENST00000532925	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000371945	ENST00000542495	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000371946	ENST00000329231	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000371946	ENST00000525633	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000371946	ENST00000532925	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000371946	ENST00000542495	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000428112	ENST00000329231	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000428112	ENST00000525633	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000428112	ENST00000532925	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000428112	ENST00000542495	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000465783	ENST00000329231	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000465783	ENST00000525633	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000465783	ENST00000532925	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000465783	ENST00000542495	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000525888	ENST00000329231	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000525888	ENST00000525633	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000525888	ENST00000532925	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-5UTR	ENST00000525888	ENST00000542495	MKNK1	chr1	47082383	-	ATPAF1	chr1	47131036	-
intron-intron	ENST00000341183	ENST00000525633	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-intron	ENST00000371944	ENST00000329231	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
intron-intron	ENST00000371944	ENST00000371937	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
intron-intron	ENST00000371944	ENST00000525633	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-intron	ENST00000371944	ENST00000525633	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-intron	ENST00000371944	ENST00000525633	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
intron-intron	ENST00000371944	ENST00000532925	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
intron-intron	ENST00000371944	ENST00000542495	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
intron-intron	ENST00000371944	ENST00000574428	MKNK1	chr1	47059784	-	ATPAF1	chr1	47110928	-
intron-intron	ENST00000371945	ENST00000525633	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-intron	ENST00000371946	ENST00000525633	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-intron	ENST00000428112	ENST00000525633	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-intron	ENST00000465783	ENST00000525633	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-intron	ENST00000465783	ENST00000525633	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-intron	ENST00000525888	ENST00000525633	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-
intron-intron	ENST00000545730	ENST00000525633	MKNK1	chr1	47069857	-	ATPAF1	chr1	47118300	-
intron-intron	ENST00000545730	ENST00000525633	MKNK1	chr1	47069899	-	ATPAF1	chr1	47118300	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for MKNK1-ATPAF1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MKNK1-ATPAF1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:47059784/chr1:47110928)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MKNK1 Q9BUB5	ATPAF1 Q5TC12
FUNCTION: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269\|PubMed:11463832, ECO:0000269\|PubMed:15350534, ECO:0000269\|PubMed:9155018, ECO:0000269\|PubMed:9878069}.	FUNCTION: May play an essential role for the assembly of the mitochondrial F1-F0 complex. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MKNK1

chr1:47059784

chr1:47110928

ENST00000341183

49_374

348.0

Domain

Protein kinase

Hgene

MKNK1

chr1:47059784

chr1:47110928

ENST00000371945

49_374

425.0

Domain

Protein kinase

Hgene

MKNK1

chr1:47059784

chr1:47110928

ENST00000371946

49_374

466.0

Domain

Protein kinase

Hgene

MKNK1

chr1:47059784

chr1:47110928

ENST00000428112

49_374

348.0

Domain

Protein kinase

Hgene

MKNK1

chr1:47059784

chr1:47110928

ENST00000341183

55_63

348.0

Nucleotide binding

ATP

Hgene

MKNK1

chr1:47059784

chr1:47110928

ENST00000371945

55_63

425.0

Nucleotide binding

ATP

Hgene

MKNK1

chr1:47059784

chr1:47110928

ENST00000371946

55_63

466.0

Nucleotide binding

ATP

Hgene

MKNK1

chr1:47059784

chr1:47110928

ENST00000428112

55_63

348.0

Nucleotide binding

ATP

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Fusion Gene Sequence for MKNK1-ATPAF1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MKNK1-ATPAF1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MKNK1-ATPAF1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MKNK1-ATPAF1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source