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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MKNK2-ORC3 (FusionGDB2 ID:54105)

Fusion Gene Summary for MKNK2-ORC3

check button Fusion gene summary
Fusion gene informationFusion gene name: MKNK2-ORC3
Fusion gene ID: 54105
HgeneTgene
Gene symbol

MKNK2

ORC3

Gene ID

2872

23595

Gene nameMAPK interacting serine/threonine kinase 2origin recognition complex subunit 3
SynonymsGPRK7|MNK2LAT|LATHEO|ORC3L
Cytomap

19p13.3

6q15

Type of geneprotein-codingprotein-coding
DescriptionMAP kinase-interacting serine/threonine-protein kinase 2G protein-coupled receptor kinase 7MAP kinase interacting serine/threonine kinase 2MAP kinase signal-integrating kinase 2MAPK signal-integrating kinase 2origin recognition complex subunit 3homolog of latheo, Drosophilaorigin recognition complex subunit Latheoorigin recognition complex, subunit 3 honolog
Modification date2020031320200313
UniProtAcc

Q9HBH9

.
Ensembl transtripts involved in fusion geneENST00000250896, ENST00000309340, 
ENST00000541165, ENST00000588014, 
ENST00000591142, ENST00000591588, 
ENST00000591601, 		ENST00000257789, 
ENST00000392844, ENST00000417380, 
ENST00000478028, ENST00000546266, 
Fusion gene scores* DoF score12 X 12 X 6=8643 X 3 X 4=36
# samples 134
** MAII scorelog2(13/864*10)=-2.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MKNK2 [Title/Abstract] AND ORC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMKNK2(2037862)-ORC3(88306179), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMKNK2

GO:0006468

protein phosphorylation

11463832

HgeneMKNK2

GO:0030097

hemopoiesis

21149447

HgeneMKNK2

GO:0035556

intracellular signal transduction

11463832

HgeneMKNK2

GO:0071243

cellular response to arsenic-containing substance

18299328

TgeneORC3

GO:0006275

regulation of DNA replication

31160578


check buttonFusion gene breakpoints across MKNK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ORC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAI096463MKNK2chr19

2037862

+ORC3chr6

88306179

-


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Fusion Gene ORF analysis for MKNK2-ORC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000250896ENST00000257789MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000250896ENST00000392844MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000250896ENST00000417380MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000250896ENST00000478028MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000250896ENST00000546266MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000309340ENST00000257789MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000309340ENST00000392844MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000309340ENST00000417380MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000309340ENST00000478028MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000309340ENST00000546266MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000541165ENST00000257789MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000541165ENST00000392844MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000541165ENST00000417380MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000541165ENST00000478028MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000541165ENST00000546266MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000588014ENST00000257789MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000588014ENST00000392844MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000588014ENST00000417380MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000588014ENST00000478028MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000588014ENST00000546266MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000591142ENST00000257789MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000591142ENST00000392844MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000591142ENST00000417380MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000591142ENST00000478028MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000591142ENST00000546266MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000591588ENST00000257789MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000591588ENST00000392844MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000591588ENST00000417380MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000591588ENST00000478028MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000591588ENST00000546266MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000591601ENST00000257789MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000591601ENST00000392844MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000591601ENST00000417380MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000591601ENST00000478028MKNK2chr19

2037862

+ORC3chr6

88306179

-
intron-intronENST00000591601ENST00000546266MKNK2chr19

2037862

+ORC3chr6

88306179

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MKNK2-ORC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MKNK2-ORC3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:2037862/:88306179)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MKNK2

Q9HBH9

.
FUNCTION: Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MKNK2-ORC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MKNK2-ORC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MKNK2-ORC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MKNK2-ORC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource