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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MKRN1-MRPS33 (FusionGDB2 ID:54117)

Fusion Gene Summary for MKRN1-MRPS33

check button Fusion gene summary
Fusion gene informationFusion gene name: MKRN1-MRPS33
Fusion gene ID: 54117
HgeneTgene
Gene symbol

MKRN1

MRPS33

Gene ID

23608

51650

Gene namemakorin ring finger protein 1mitochondrial ribosomal protein S33
SynonymsRNF61CGI-139|MRP-S33|PTD003|S33mt
Cytomap

7q34

7q34

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase makorin-1RING finger protein 61RING-type E3 ubiquitin transferase makorin-128S ribosomal protein S33, mitochondrialmitochondrial small ribosomal subunit protein mS33
Modification date2020031320200313
UniProtAcc

Q9UHC7

.
Ensembl transtripts involved in fusion geneENST00000255977, ENST00000443720, 
ENST00000437223, ENST00000481705, 
ENST00000474576, ENST00000480552, 
ENST00000324787, ENST00000393008, 
ENST00000467334, ENST00000469351, 
ENST00000472343, ENST00000496958, 
Fusion gene scores* DoF score10 X 11 X 9=9904 X 4 X 4=64
# samples 155
** MAII scorelog2(15/990*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MKRN1 [Title/Abstract] AND MRPS33 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMKRN1(140178960)-MRPS33(140710460), # samples:3
Anticipated loss of major functional domain due to fusion event.MKRN1-MRPS33 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MKRN1-MRPS33 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMKRN1

GO:0000209

protein polyubiquitination

19536131


check buttonFusion gene breakpoints across MKRN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MRPS33 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-36-1577-01AMKRN1chr7

140178960

-MRPS33chr7

140706335

-
ChimerDB4OVTCGA-36-1577-01AMKRN1chr7

140178960

-MRPS33chr7

140710417

-
ChimerDB4OVTCGA-36-1577-01AMKRN1chr7

140178960

-MRPS33chr7

140710460

-
ChimerDB4OVTCGA-36-1577MKRN1chr7

140178959

-MRPS33chr7

140706335

-
ChimerDB4OVTCGA-36-1577MKRN1chr7

140178959

-MRPS33chr7

140710460

-


Top

Fusion Gene ORF analysis for MKRN1-MRPS33

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000255977ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5CDS-5UTRENST00000255977ENST00000324787MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5CDS-5UTRENST00000255977ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5CDS-5UTRENST00000255977ENST00000393008MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5CDS-5UTRENST00000255977ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5CDS-5UTRENST00000255977ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5CDS-5UTRENST00000255977ENST00000467334MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5CDS-5UTRENST00000255977ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5CDS-5UTRENST00000255977ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5CDS-5UTRENST00000255977ENST00000469351MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5CDS-5UTRENST00000255977ENST00000469351MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5CDS-5UTRENST00000255977ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5CDS-5UTRENST00000255977ENST00000472343MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5CDS-5UTRENST00000255977ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5CDS-5UTRENST00000255977ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5CDS-5UTRENST00000255977ENST00000496958MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5CDS-5UTRENST00000255977ENST00000496958MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5CDS-5UTRENST00000443720ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5CDS-5UTRENST00000443720ENST00000324787MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5CDS-5UTRENST00000443720ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5CDS-5UTRENST00000443720ENST00000393008MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5CDS-5UTRENST00000443720ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5CDS-5UTRENST00000443720ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5CDS-5UTRENST00000443720ENST00000467334MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5CDS-5UTRENST00000443720ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5CDS-5UTRENST00000443720ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5CDS-5UTRENST00000443720ENST00000469351MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5CDS-5UTRENST00000443720ENST00000469351MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5CDS-5UTRENST00000443720ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5CDS-5UTRENST00000443720ENST00000472343MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5CDS-5UTRENST00000443720ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5CDS-5UTRENST00000443720ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5CDS-5UTRENST00000443720ENST00000496958MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5CDS-5UTRENST00000443720ENST00000496958MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5CDS-intronENST00000255977ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5CDS-intronENST00000255977ENST00000467334MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5CDS-intronENST00000255977ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5CDS-intronENST00000255977ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5CDS-intronENST00000255977ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5CDS-intronENST00000255977ENST00000472343MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5CDS-intronENST00000255977ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5CDS-intronENST00000443720ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5CDS-intronENST00000443720ENST00000467334MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5CDS-intronENST00000443720ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5CDS-intronENST00000443720ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5CDS-intronENST00000443720ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5CDS-intronENST00000443720ENST00000472343MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5CDS-intronENST00000443720ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5UTR-3CDSENST00000437223ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5UTR-3CDSENST00000437223ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5UTR-3CDSENST00000437223ENST00000324787MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5UTR-3CDSENST00000437223ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5UTR-3CDSENST00000437223ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5UTR-3CDSENST00000437223ENST00000393008MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5UTR-3CDSENST00000481705ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5UTR-3CDSENST00000481705ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5UTR-3CDSENST00000481705ENST00000324787MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5UTR-3CDSENST00000481705ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5UTR-3CDSENST00000481705ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5UTR-3CDSENST00000481705ENST00000393008MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000437223ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5UTR-5UTRENST00000437223ENST00000324787MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5UTR-5UTRENST00000437223ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5UTR-5UTRENST00000437223ENST00000393008MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5UTR-5UTRENST00000437223ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000437223ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5UTR-5UTRENST00000437223ENST00000467334MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000437223ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000437223ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5UTR-5UTRENST00000437223ENST00000469351MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000437223ENST00000469351MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5UTR-5UTRENST00000437223ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000437223ENST00000472343MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000437223ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000437223ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5UTR-5UTRENST00000437223ENST00000496958MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000437223ENST00000496958MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5UTR-5UTRENST00000481705ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5UTR-5UTRENST00000481705ENST00000324787MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5UTR-5UTRENST00000481705ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5UTR-5UTRENST00000481705ENST00000393008MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5UTR-5UTRENST00000481705ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000481705ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5UTR-5UTRENST00000481705ENST00000467334MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000481705ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000481705ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5UTR-5UTRENST00000481705ENST00000469351MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000481705ENST00000469351MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5UTR-5UTRENST00000481705ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000481705ENST00000472343MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000481705ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000481705ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5UTR-5UTRENST00000481705ENST00000496958MKRN1chr7

140178959

-MRPS33chr7

140706335

-
5UTR-5UTRENST00000481705ENST00000496958MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5UTR-intronENST00000437223ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5UTR-intronENST00000437223ENST00000467334MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5UTR-intronENST00000437223ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5UTR-intronENST00000437223ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5UTR-intronENST00000437223ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5UTR-intronENST00000437223ENST00000472343MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5UTR-intronENST00000437223ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5UTR-intronENST00000481705ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5UTR-intronENST00000481705ENST00000467334MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5UTR-intronENST00000481705ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5UTR-intronENST00000481705ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140710417

-
5UTR-intronENST00000481705ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140710460

-
5UTR-intronENST00000481705ENST00000472343MKRN1chr7

140178959

-MRPS33chr7

140710460

-
5UTR-intronENST00000481705ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140710417

-
Frame-shiftENST00000255977ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140706335

-
Frame-shiftENST00000255977ENST00000324787MKRN1chr7

140178959

-MRPS33chr7

140706335

-
Frame-shiftENST00000443720ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140706335

-
Frame-shiftENST00000443720ENST00000324787MKRN1chr7

140178959

-MRPS33chr7

140706335

-
In-frameENST00000255977ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140710417

-
In-frameENST00000255977ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140706335

-
In-frameENST00000255977ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140710417

-
In-frameENST00000255977ENST00000393008MKRN1chr7

140178959

-MRPS33chr7

140706335

-
In-frameENST00000443720ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140710417

-
In-frameENST00000443720ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140706335

-
In-frameENST00000443720ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140710417

-
In-frameENST00000443720ENST00000393008MKRN1chr7

140178959

-MRPS33chr7

140706335

-
intron-3CDSENST00000474576ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140706335

-
intron-3CDSENST00000474576ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140710417

-
intron-3CDSENST00000474576ENST00000324787MKRN1chr7

140178959

-MRPS33chr7

140706335

-
intron-3CDSENST00000474576ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140706335

-
intron-3CDSENST00000474576ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140710417

-
intron-3CDSENST00000474576ENST00000393008MKRN1chr7

140178959

-MRPS33chr7

140706335

-
intron-3CDSENST00000480552ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140706335

-
intron-3CDSENST00000480552ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140710417

-
intron-3CDSENST00000480552ENST00000324787MKRN1chr7

140178959

-MRPS33chr7

140706335

-
intron-3CDSENST00000480552ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140706335

-
intron-3CDSENST00000480552ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140710417

-
intron-3CDSENST00000480552ENST00000393008MKRN1chr7

140178959

-MRPS33chr7

140706335

-
intron-5UTRENST00000474576ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140710460

-
intron-5UTRENST00000474576ENST00000324787MKRN1chr7

140178959

-MRPS33chr7

140710460

-
intron-5UTRENST00000474576ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140710460

-
intron-5UTRENST00000474576ENST00000393008MKRN1chr7

140178959

-MRPS33chr7

140710460

-
intron-5UTRENST00000474576ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140706335

-
intron-5UTRENST00000474576ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140710417

-
intron-5UTRENST00000474576ENST00000467334MKRN1chr7

140178959

-MRPS33chr7

140706335

-
intron-5UTRENST00000474576ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140706335

-
intron-5UTRENST00000474576ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140710460

-
intron-5UTRENST00000474576ENST00000469351MKRN1chr7

140178959

-MRPS33chr7

140706335

-
intron-5UTRENST00000474576ENST00000469351MKRN1chr7

140178959

-MRPS33chr7

140710460

-
intron-5UTRENST00000474576ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140706335

-
intron-5UTRENST00000474576ENST00000472343MKRN1chr7

140178959

-MRPS33chr7

140706335

-
intron-5UTRENST00000474576ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140706335

-
intron-5UTRENST00000474576ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140710460

-
intron-5UTRENST00000474576ENST00000496958MKRN1chr7

140178959

-MRPS33chr7

140706335

-
intron-5UTRENST00000474576ENST00000496958MKRN1chr7

140178959

-MRPS33chr7

140710460

-
intron-5UTRENST00000480552ENST00000324787MKRN1chr7

140178960

-MRPS33chr7

140710460

-
intron-5UTRENST00000480552ENST00000324787MKRN1chr7

140178959

-MRPS33chr7

140710460

-
intron-5UTRENST00000480552ENST00000393008MKRN1chr7

140178960

-MRPS33chr7

140710460

-
intron-5UTRENST00000480552ENST00000393008MKRN1chr7

140178959

-MRPS33chr7

140710460

-
intron-5UTRENST00000480552ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140706335

-
intron-5UTRENST00000480552ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140710417

-
intron-5UTRENST00000480552ENST00000467334MKRN1chr7

140178959

-MRPS33chr7

140706335

-
intron-5UTRENST00000480552ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140706335

-
intron-5UTRENST00000480552ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140710460

-
intron-5UTRENST00000480552ENST00000469351MKRN1chr7

140178959

-MRPS33chr7

140706335

-
intron-5UTRENST00000480552ENST00000469351MKRN1chr7

140178959

-MRPS33chr7

140710460

-
intron-5UTRENST00000480552ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140706335

-
intron-5UTRENST00000480552ENST00000472343MKRN1chr7

140178959

-MRPS33chr7

140706335

-
intron-5UTRENST00000480552ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140706335

-
intron-5UTRENST00000480552ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140710460

-
intron-5UTRENST00000480552ENST00000496958MKRN1chr7

140178959

-MRPS33chr7

140706335

-
intron-5UTRENST00000480552ENST00000496958MKRN1chr7

140178959

-MRPS33chr7

140710460

-
intron-intronENST00000474576ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140710460

-
intron-intronENST00000474576ENST00000467334MKRN1chr7

140178959

-MRPS33chr7

140710460

-
intron-intronENST00000474576ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140710417

-
intron-intronENST00000474576ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140710417

-
intron-intronENST00000474576ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140710460

-
intron-intronENST00000474576ENST00000472343MKRN1chr7

140178959

-MRPS33chr7

140710460

-
intron-intronENST00000474576ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140710417

-
intron-intronENST00000480552ENST00000467334MKRN1chr7

140178960

-MRPS33chr7

140710460

-
intron-intronENST00000480552ENST00000467334MKRN1chr7

140178959

-MRPS33chr7

140710460

-
intron-intronENST00000480552ENST00000469351MKRN1chr7

140178960

-MRPS33chr7

140710417

-
intron-intronENST00000480552ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140710417

-
intron-intronENST00000480552ENST00000472343MKRN1chr7

140178960

-MRPS33chr7

140710460

-
intron-intronENST00000480552ENST00000472343MKRN1chr7

140178959

-MRPS33chr7

140710460

-
intron-intronENST00000480552ENST00000496958MKRN1chr7

140178960

-MRPS33chr7

140710417

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000255977MKRN1chr7140178959-ENST00000393008MRPS33chr7140706335-89241022551596
ENST00000443720MKRN1chr7140178959-ENST00000393008MRPS33chr7140706335-82234015544596
ENST00000255977MKRN1chr7140178960-ENST00000393008MRPS33chr7140706335-89241022551596
ENST00000443720MKRN1chr7140178960-ENST00000393008MRPS33chr7140706335-82234015544596
ENST00000255977MKRN1chr7140178960-ENST00000393008MRPS33chr7140710417-10914104092136
ENST00000255977MKRN1chr7140178960-ENST00000324787MRPS33chr7140710417-9844104092136
ENST00000443720MKRN1chr7140178960-ENST00000393008MRPS33chr7140710417-10213403391113
ENST00000443720MKRN1chr7140178960-ENST00000324787MRPS33chr7140710417-9143403391113

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000255977ENST00000393008MKRN1chr7140178959-MRPS33chr7140706335-0.17345430.82654566
ENST00000443720ENST00000393008MKRN1chr7140178959-MRPS33chr7140706335-0.248457920.75154203
ENST00000255977ENST00000393008MKRN1chr7140178960-MRPS33chr7140706335-0.17345430.82654566
ENST00000443720ENST00000393008MKRN1chr7140178960-MRPS33chr7140706335-0.248457920.75154203
ENST00000255977ENST00000393008MKRN1chr7140178960-MRPS33chr7140710417-0.175576450.8244235
ENST00000255977ENST00000324787MKRN1chr7140178960-MRPS33chr7140710417-0.165272890.83472705
ENST00000443720ENST00000393008MKRN1chr7140178960-MRPS33chr7140710417-0.198967140.80103284
ENST00000443720ENST00000324787MKRN1chr7140178960-MRPS33chr7140710417-0.209681590.7903184

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Fusion Genomic Features for MKRN1-MRPS33


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MKRN1-MRPS33


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:140178960/chr7:140710460)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MKRN1

Q9UHC7

.
FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. {ECO:0000269|PubMed:16785614, ECO:0000269|PubMed:19536131}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMKRN1chr7:140178959chr7:140706335ENST00000255977-18236_26361483.0RegionNote=Makorin-type Cys-His
HgeneMKRN1chr7:140178959chr7:140706335ENST00000443720-15236_26361330.0RegionNote=Makorin-type Cys-His
HgeneMKRN1chr7:140178959chr7:140706335ENST00000474576-18236_2630419.0RegionNote=Makorin-type Cys-His
HgeneMKRN1chr7:140178960chr7:140706335ENST00000255977-18236_26361483.0RegionNote=Makorin-type Cys-His
HgeneMKRN1chr7:140178960chr7:140706335ENST00000443720-15236_26361330.0RegionNote=Makorin-type Cys-His
HgeneMKRN1chr7:140178960chr7:140706335ENST00000474576-18236_2630419.0RegionNote=Makorin-type Cys-His
HgeneMKRN1chr7:140178960chr7:140710417ENST00000255977-18236_26361483.0RegionNote=Makorin-type Cys-His
HgeneMKRN1chr7:140178960chr7:140710417ENST00000443720-15236_26361330.0RegionNote=Makorin-type Cys-His
HgeneMKRN1chr7:140178960chr7:140710417ENST00000474576-18236_2630419.0RegionNote=Makorin-type Cys-His
HgeneMKRN1chr7:140178959chr7:140706335ENST00000255977-18208_23561483.0Zinc fingerC3H1-type 3
HgeneMKRN1chr7:140178959chr7:140706335ENST00000255977-18281_33561483.0Zinc fingerRING-type
HgeneMKRN1chr7:140178959chr7:140706335ENST00000255977-18364_39361483.0Zinc fingerC3H1-type 4
HgeneMKRN1chr7:140178959chr7:140706335ENST00000255977-1855_8261483.0Zinc fingerC3H1-type 1
HgeneMKRN1chr7:140178959chr7:140706335ENST00000255977-1884_11161483.0Zinc fingerC3H1-type 2
HgeneMKRN1chr7:140178959chr7:140706335ENST00000443720-15208_23561330.0Zinc fingerC3H1-type 3
HgeneMKRN1chr7:140178959chr7:140706335ENST00000443720-15281_33561330.0Zinc fingerRING-type
HgeneMKRN1chr7:140178959chr7:140706335ENST00000443720-15364_39361330.0Zinc fingerC3H1-type 4
HgeneMKRN1chr7:140178959chr7:140706335ENST00000443720-1555_8261330.0Zinc fingerC3H1-type 1
HgeneMKRN1chr7:140178959chr7:140706335ENST00000443720-1584_11161330.0Zinc fingerC3H1-type 2
HgeneMKRN1chr7:140178959chr7:140706335ENST00000474576-18208_2350419.0Zinc fingerC3H1-type 3
HgeneMKRN1chr7:140178959chr7:140706335ENST00000474576-18281_3350419.0Zinc fingerRING-type
HgeneMKRN1chr7:140178959chr7:140706335ENST00000474576-18364_3930419.0Zinc fingerC3H1-type 4
HgeneMKRN1chr7:140178959chr7:140706335ENST00000474576-1855_820419.0Zinc fingerC3H1-type 1
HgeneMKRN1chr7:140178959chr7:140706335ENST00000474576-1884_1110419.0Zinc fingerC3H1-type 2
HgeneMKRN1chr7:140178960chr7:140706335ENST00000255977-18208_23561483.0Zinc fingerC3H1-type 3
HgeneMKRN1chr7:140178960chr7:140706335ENST00000255977-18281_33561483.0Zinc fingerRING-type
HgeneMKRN1chr7:140178960chr7:140706335ENST00000255977-18364_39361483.0Zinc fingerC3H1-type 4
HgeneMKRN1chr7:140178960chr7:140706335ENST00000255977-1855_8261483.0Zinc fingerC3H1-type 1
HgeneMKRN1chr7:140178960chr7:140706335ENST00000255977-1884_11161483.0Zinc fingerC3H1-type 2
HgeneMKRN1chr7:140178960chr7:140706335ENST00000443720-15208_23561330.0Zinc fingerC3H1-type 3
HgeneMKRN1chr7:140178960chr7:140706335ENST00000443720-15281_33561330.0Zinc fingerRING-type
HgeneMKRN1chr7:140178960chr7:140706335ENST00000443720-15364_39361330.0Zinc fingerC3H1-type 4
HgeneMKRN1chr7:140178960chr7:140706335ENST00000443720-1555_8261330.0Zinc fingerC3H1-type 1
HgeneMKRN1chr7:140178960chr7:140706335ENST00000443720-1584_11161330.0Zinc fingerC3H1-type 2
HgeneMKRN1chr7:140178960chr7:140706335ENST00000474576-18208_2350419.0Zinc fingerC3H1-type 3
HgeneMKRN1chr7:140178960chr7:140706335ENST00000474576-18281_3350419.0Zinc fingerRING-type
HgeneMKRN1chr7:140178960chr7:140706335ENST00000474576-18364_3930419.0Zinc fingerC3H1-type 4
HgeneMKRN1chr7:140178960chr7:140706335ENST00000474576-1855_820419.0Zinc fingerC3H1-type 1
HgeneMKRN1chr7:140178960chr7:140706335ENST00000474576-1884_1110419.0Zinc fingerC3H1-type 2
HgeneMKRN1chr7:140178960chr7:140710417ENST00000255977-18208_23561483.0Zinc fingerC3H1-type 3
HgeneMKRN1chr7:140178960chr7:140710417ENST00000255977-18281_33561483.0Zinc fingerRING-type
HgeneMKRN1chr7:140178960chr7:140710417ENST00000255977-18364_39361483.0Zinc fingerC3H1-type 4
HgeneMKRN1chr7:140178960chr7:140710417ENST00000255977-1855_8261483.0Zinc fingerC3H1-type 1
HgeneMKRN1chr7:140178960chr7:140710417ENST00000255977-1884_11161483.0Zinc fingerC3H1-type 2
HgeneMKRN1chr7:140178960chr7:140710417ENST00000443720-15208_23561330.0Zinc fingerC3H1-type 3
HgeneMKRN1chr7:140178960chr7:140710417ENST00000443720-15281_33561330.0Zinc fingerRING-type
HgeneMKRN1chr7:140178960chr7:140710417ENST00000443720-15364_39361330.0Zinc fingerC3H1-type 4
HgeneMKRN1chr7:140178960chr7:140710417ENST00000443720-1555_8261330.0Zinc fingerC3H1-type 1
HgeneMKRN1chr7:140178960chr7:140710417ENST00000443720-1584_11161330.0Zinc fingerC3H1-type 2
HgeneMKRN1chr7:140178960chr7:140710417ENST00000474576-18208_2350419.0Zinc fingerC3H1-type 3
HgeneMKRN1chr7:140178960chr7:140710417ENST00000474576-18281_3350419.0Zinc fingerRING-type
HgeneMKRN1chr7:140178960chr7:140710417ENST00000474576-18364_3930419.0Zinc fingerC3H1-type 4
HgeneMKRN1chr7:140178960chr7:140710417ENST00000474576-1855_820419.0Zinc fingerC3H1-type 1
HgeneMKRN1chr7:140178960chr7:140710417ENST00000474576-1884_1110419.0Zinc fingerC3H1-type 2


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Fusion Gene Sequence for MKRN1-MRPS33


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54117_54117_1_MKRN1-MRPS33_MKRN1_chr7_140178959_ENST00000255977_MRPS33_chr7_140706335_ENST00000393008_length(transcript)=892nt_BP=410nt
ACCAATGAGCGGCGCCGTGGGCGGGCCGCGGGCGCGCATGCTCTGGGCCCGCAGTTGAAGTGGCGAGAGCGCTCAGATACGCGACGCGTA
GCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCCGCAGCCGGACCGGAACTATG
TGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAACAACAGCCACAACATCAGGA
GCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCCTGGGGGCGGGCGGAGGGGGC
GGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAGAGATGAGCATCAGGATTTTATGGATGAGCAAAAACGACTA
AAGAAGCTTCGTGGAAAGGAGAAACCAAAGAAAGGAGAAGGGAAAAGAGCAGCAAAAAGGAAATAGTGTTGGTCCCTCAAGAGGGAGACT
TTCTTCCTCAGTGGCGGAGAGAAGAAAGTGCATTTATTGTCTTTCCACCTATTGGAGGAATGTCATCTTCCTAAATGAAGTTTATTTGGA
GGAACACAGTCATCTCCTTGGTGAAATCTAATCCGGTTACATTGTGGCTGGTTTCTTGAACACATTCTAACTGTGCAAAATTATCTTGGC
CTTGGCCGTGTAATGTGAGGTTTACCTGATTCTCTAATGAAATAAATACCTAAGTTATTGTTTGATGATTTGTTTGGGGTGGGATGGGAT

>54117_54117_1_MKRN1-MRPS33_MKRN1_chr7_140178959_ENST00000255977_MRPS33_chr7_140706335_ENST00000393008_length(amino acids)=96AA_BP=61
MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRDEHQDFMDEQKRLKKLRGKEKPKKGEGK

--------------------------------------------------------------
>54117_54117_2_MKRN1-MRPS33_MKRN1_chr7_140178959_ENST00000443720_MRPS33_chr7_140706335_ENST00000393008_length(transcript)=822nt_BP=340nt
GCTCAGATACGCGACGCGTAGCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCC
GCAGCCGGACCGGAACTATGTGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAA
CAACAGCCACAACATCAGGAGCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCC
TGGGGGCGGGCGGAGGGGGCGGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAGAGATGAGCATCAGGATTTTA
TGGATGAGCAAAAACGACTAAAGAAGCTTCGTGGAAAGGAGAAACCAAAGAAAGGAGAAGGGAAAAGAGCAGCAAAAAGGAAATAGTGTT
GGTCCCTCAAGAGGGAGACTTTCTTCCTCAGTGGCGGAGAGAAGAAAGTGCATTTATTGTCTTTCCACCTATTGGAGGAATGTCATCTTC
CTAAATGAAGTTTATTTGGAGGAACACAGTCATCTCCTTGGTGAAATCTAATCCGGTTACATTGTGGCTGGTTTCTTGAACACATTCTAA
CTGTGCAAAATTATCTTGGCCTTGGCCGTGTAATGTGAGGTTTACCTGATTCTCTAATGAAATAAATACCTAAGTTATTGTTTGATGATT
TGTTTGGGGTGGGATGGGATGCTGGGGGAATGGAGGGGAAACCTCATTAAGTGAGCATCCTATAGTGTCCTCATTTCTCCCTTCTTGCTT

>54117_54117_2_MKRN1-MRPS33_MKRN1_chr7_140178959_ENST00000443720_MRPS33_chr7_140706335_ENST00000393008_length(amino acids)=96AA_BP=61
MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRDEHQDFMDEQKRLKKLRGKEKPKKGEGK

--------------------------------------------------------------
>54117_54117_3_MKRN1-MRPS33_MKRN1_chr7_140178960_ENST00000255977_MRPS33_chr7_140706335_ENST00000393008_length(transcript)=892nt_BP=410nt
ACCAATGAGCGGCGCCGTGGGCGGGCCGCGGGCGCGCATGCTCTGGGCCCGCAGTTGAAGTGGCGAGAGCGCTCAGATACGCGACGCGTA
GCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCCGCAGCCGGACCGGAACTATG
TGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAACAACAGCCACAACATCAGGA
GCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCCTGGGGGCGGGCGGAGGGGGC
GGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAGAGATGAGCATCAGGATTTTATGGATGAGCAAAAACGACTA
AAGAAGCTTCGTGGAAAGGAGAAACCAAAGAAAGGAGAAGGGAAAAGAGCAGCAAAAAGGAAATAGTGTTGGTCCCTCAAGAGGGAGACT
TTCTTCCTCAGTGGCGGAGAGAAGAAAGTGCATTTATTGTCTTTCCACCTATTGGAGGAATGTCATCTTCCTAAATGAAGTTTATTTGGA
GGAACACAGTCATCTCCTTGGTGAAATCTAATCCGGTTACATTGTGGCTGGTTTCTTGAACACATTCTAACTGTGCAAAATTATCTTGGC
CTTGGCCGTGTAATGTGAGGTTTACCTGATTCTCTAATGAAATAAATACCTAAGTTATTGTTTGATGATTTGTTTGGGGTGGGATGGGAT

>54117_54117_3_MKRN1-MRPS33_MKRN1_chr7_140178960_ENST00000255977_MRPS33_chr7_140706335_ENST00000393008_length(amino acids)=96AA_BP=61
MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRDEHQDFMDEQKRLKKLRGKEKPKKGEGK

--------------------------------------------------------------
>54117_54117_4_MKRN1-MRPS33_MKRN1_chr7_140178960_ENST00000255977_MRPS33_chr7_140710417_ENST00000324787_length(transcript)=984nt_BP=410nt
ACCAATGAGCGGCGCCGTGGGCGGGCCGCGGGCGCGCATGCTCTGGGCCCGCAGTTGAAGTGGCGAGAGCGCTCAGATACGCGACGCGTA
GCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCCGCAGCCGGACCGGAACTATG
TGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAACAACAGCCACAACATCAGGA
GCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCCTGGGGGCGGGCGGAGGGGGC
GGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAGAGATGAGCATCAGGATTTTATGGATGAGCAAAAACGACTA
AAGAAGCTTCGTGGAAAGGAGAAACCAAAGAAAGGAGAAGGGAAAAGAGCAGCAAAAAGGAAATAGTGTTGGTCCCTCAAGAGGGAGACT
TTCTTCCTCAGTGGCGGAGAGAAGAAAGTGCATTTATTGTCTTTCCACCTATTGGAGGAATGTCATCTTCCTAAATGAAGTTTATTTGGA
GGAACACAGTCATCTCCTTGGTGAAATCTAATCCGGTTACATTGTGGCTGGTTTCTTGAACACATTCTAACTGTGCAAAATTATCTTGGC
CTTGGCCGTGTAATGTGAGGTTTACCTGATTCTCTAATGAAATAAATACCTAAGTTATTGTTTGAAATATGCCTTCCGCATGTCTCGTCT
CAGTGCCCGGCTATTTGGTGAAGTCACCAGGCCTACTAATTCCAAGTCTATGAAAGTGGTGAAACTGTTTAGTGAACTGCCCTTGGCCAA

>54117_54117_4_MKRN1-MRPS33_MKRN1_chr7_140178960_ENST00000255977_MRPS33_chr7_140710417_ENST00000324787_length(amino acids)=136AA_BP=
MQVTCLVQPPPLPSLPPPPPPAPRDGAVTVGIGVGEAAAAVAAAAPAPDVVAVVPGVAASAITVYPTQQRPRNFRDHIVPVRLRGEDGEA

--------------------------------------------------------------
>54117_54117_5_MKRN1-MRPS33_MKRN1_chr7_140178960_ENST00000255977_MRPS33_chr7_140710417_ENST00000393008_length(transcript)=1091nt_BP=410nt
ACCAATGAGCGGCGCCGTGGGCGGGCCGCGGGCGCGCATGCTCTGGGCCCGCAGTTGAAGTGGCGAGAGCGCTCAGATACGCGACGCGTA
GCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCCGCAGCCGGACCGGAACTATG
TGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAACAACAGCCACAACATCAGGA
GCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCCTGGGGGCGGGCGGAGGGGGC
GGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAGAGATGAGCATCAGGATTTTATGGATGAGCAAAAACGACTA
AAGAAGCTTCGTGGAAAGGAGAAACCAAAGAAAGGAGAAGGGAAAAGAGCAGCAAAAAGGAAATAGTGTTGGTCCCTCAAGAGGGAGACT
TTCTTCCTCAGTGGCGGAGAGAAGAAAGTGCATTTATTGTCTTTCCACCTATTGGAGGAATGTCATCTTCCTAAATGAAGTTTATTTGGA
GGAACACAGTCATCTCCTTGGTGAAATCTAATCCGGTTACATTGTGGCTGGTTTCTTGAACACATTCTAACTGTGCAAAATTATCTTGGC
CTTGGCCGTGTAATGTGAGGTTTACCTGATTCTCTAATGAAATAAATACCTAAGTTATTGTTTGATGATTTGTTTGGGGTGGGATGGGAT
GCTGGGGGAATGGAGGGGAAACCTCATTAAGTGAGCATCCTATAGTGTCCTCATTTCTCCCTTCTTGCTTACTGACTCACCCAATATGCC
TTCCGCATGTCTCGTCTCAGTGCCCGGCTATTTGGTGAAGTCACCAGGCCTACTAATTCCAAGTCTATGAAAGTGGTGAAACTGTTTAGT
GAACTGCCCTTGGCCAAGAAGAAGGAGACTTATGATTGGTATCCAAATCACCACACTTACGCTGAACTCATGCAGACGCTCCGATTTCTT

>54117_54117_5_MKRN1-MRPS33_MKRN1_chr7_140178960_ENST00000255977_MRPS33_chr7_140710417_ENST00000393008_length(amino acids)=136AA_BP=
MQVTCLVQPPPLPSLPPPPPPAPRDGAVTVGIGVGEAAAAVAAAAPAPDVVAVVPGVAASAITVYPTQQRPRNFRDHIVPVRLRGEDGEA

--------------------------------------------------------------
>54117_54117_6_MKRN1-MRPS33_MKRN1_chr7_140178960_ENST00000443720_MRPS33_chr7_140706335_ENST00000393008_length(transcript)=822nt_BP=340nt
GCTCAGATACGCGACGCGTAGCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCC
GCAGCCGGACCGGAACTATGTGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAA
CAACAGCCACAACATCAGGAGCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCC
TGGGGGCGGGCGGAGGGGGCGGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAGAGATGAGCATCAGGATTTTA
TGGATGAGCAAAAACGACTAAAGAAGCTTCGTGGAAAGGAGAAACCAAAGAAAGGAGAAGGGAAAAGAGCAGCAAAAAGGAAATAGTGTT
GGTCCCTCAAGAGGGAGACTTTCTTCCTCAGTGGCGGAGAGAAGAAAGTGCATTTATTGTCTTTCCACCTATTGGAGGAATGTCATCTTC
CTAAATGAAGTTTATTTGGAGGAACACAGTCATCTCCTTGGTGAAATCTAATCCGGTTACATTGTGGCTGGTTTCTTGAACACATTCTAA
CTGTGCAAAATTATCTTGGCCTTGGCCGTGTAATGTGAGGTTTACCTGATTCTCTAATGAAATAAATACCTAAGTTATTGTTTGATGATT
TGTTTGGGGTGGGATGGGATGCTGGGGGAATGGAGGGGAAACCTCATTAAGTGAGCATCCTATAGTGTCCTCATTTCTCCCTTCTTGCTT

>54117_54117_6_MKRN1-MRPS33_MKRN1_chr7_140178960_ENST00000443720_MRPS33_chr7_140706335_ENST00000393008_length(amino acids)=96AA_BP=61
MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRDEHQDFMDEQKRLKKLRGKEKPKKGEGK

--------------------------------------------------------------
>54117_54117_7_MKRN1-MRPS33_MKRN1_chr7_140178960_ENST00000443720_MRPS33_chr7_140710417_ENST00000324787_length(transcript)=914nt_BP=340nt
GCTCAGATACGCGACGCGTAGCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCC
GCAGCCGGACCGGAACTATGTGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAA
CAACAGCCACAACATCAGGAGCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCC
TGGGGGCGGGCGGAGGGGGCGGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAGAGATGAGCATCAGGATTTTA
TGGATGAGCAAAAACGACTAAAGAAGCTTCGTGGAAAGGAGAAACCAAAGAAAGGAGAAGGGAAAAGAGCAGCAAAAAGGAAATAGTGTT
GGTCCCTCAAGAGGGAGACTTTCTTCCTCAGTGGCGGAGAGAAGAAAGTGCATTTATTGTCTTTCCACCTATTGGAGGAATGTCATCTTC
CTAAATGAAGTTTATTTGGAGGAACACAGTCATCTCCTTGGTGAAATCTAATCCGGTTACATTGTGGCTGGTTTCTTGAACACATTCTAA
CTGTGCAAAATTATCTTGGCCTTGGCCGTGTAATGTGAGGTTTACCTGATTCTCTAATGAAATAAATACCTAAGTTATTGTTTGAAATAT
GCCTTCCGCATGTCTCGTCTCAGTGCCCGGCTATTTGGTGAAGTCACCAGGCCTACTAATTCCAAGTCTATGAAAGTGGTGAAACTGTTT
AGTGAACTGCCCTTGGCCAAGAAGAAGGAGACTTATGATTGGTATCCAAATCACCACACTTACGCTGAACTCATGCAGACGCTCCGATTT

>54117_54117_7_MKRN1-MRPS33_MKRN1_chr7_140178960_ENST00000443720_MRPS33_chr7_140710417_ENST00000324787_length(amino acids)=113AA_BP=
MQVTCLVQPPPLPSLPPPPPPAPRDGAVTVGIGVGEAAAAVAAAAPAPDVVAVVPGVAASAITVYPTQQRPRNFRDHIVPVRLRGEDGEA

--------------------------------------------------------------
>54117_54117_8_MKRN1-MRPS33_MKRN1_chr7_140178960_ENST00000443720_MRPS33_chr7_140710417_ENST00000393008_length(transcript)=1021nt_BP=340nt
GCTCAGATACGCGACGCGTAGCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCC
GCAGCCGGACCGGAACTATGTGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAA
CAACAGCCACAACATCAGGAGCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCC
TGGGGGCGGGCGGAGGGGGCGGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAGAGATGAGCATCAGGATTTTA
TGGATGAGCAAAAACGACTAAAGAAGCTTCGTGGAAAGGAGAAACCAAAGAAAGGAGAAGGGAAAAGAGCAGCAAAAAGGAAATAGTGTT
GGTCCCTCAAGAGGGAGACTTTCTTCCTCAGTGGCGGAGAGAAGAAAGTGCATTTATTGTCTTTCCACCTATTGGAGGAATGTCATCTTC
CTAAATGAAGTTTATTTGGAGGAACACAGTCATCTCCTTGGTGAAATCTAATCCGGTTACATTGTGGCTGGTTTCTTGAACACATTCTAA
CTGTGCAAAATTATCTTGGCCTTGGCCGTGTAATGTGAGGTTTACCTGATTCTCTAATGAAATAAATACCTAAGTTATTGTTTGATGATT
TGTTTGGGGTGGGATGGGATGCTGGGGGAATGGAGGGGAAACCTCATTAAGTGAGCATCCTATAGTGTCCTCATTTCTCCCTTCTTGCTT
ACTGACTCACCCAATATGCCTTCCGCATGTCTCGTCTCAGTGCCCGGCTATTTGGTGAAGTCACCAGGCCTACTAATTCCAAGTCTATGA
AAGTGGTGAAACTGTTTAGTGAACTGCCCTTGGCCAAGAAGAAGGAGACTTATGATTGGTATCCAAATCACCACACTTACGCTGAACTCA

>54117_54117_8_MKRN1-MRPS33_MKRN1_chr7_140178960_ENST00000443720_MRPS33_chr7_140710417_ENST00000393008_length(amino acids)=113AA_BP=
MQVTCLVQPPPLPSLPPPPPPAPRDGAVTVGIGVGEAAAAVAAAAPAPDVVAVVPGVAASAITVYPTQQRPRNFRDHIVPVRLRGEDGEA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MKRN1-MRPS33


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MKRN1-MRPS33


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MKRN1-MRPS33


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource