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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MLH1-GOLGA4 (FusionGDB2 ID:54168)

Fusion Gene Summary for MLH1-GOLGA4

check button Fusion gene summary
Fusion gene informationFusion gene name: MLH1-GOLGA4
Fusion gene ID: 54168
HgeneTgene
Gene symbol

MLH1

GOLGA4

Gene ID

4292

2803

Gene namemutL homolog 1golgin A4
SynonymsCOCA2|FCC2|HNPCC|HNPCC2|hMLH1CRPF46|GCP2|GOLG|MU-RMS-40.18|p230
Cytomap

3p22.2

3p22.2

Type of geneprotein-codingprotein-coding
DescriptionDNA mismatch repair protein Mlh1mutL homolog 1, colon cancer, nonpolyposis type 2golgin subfamily A member 4256 kDa golgin72.1 proteincentrosome-related protein F46golgi autoantigen, golgin subfamily a, 4golgin-240golgin-245protein 72.1trans-Golgi p230
Modification date2020032720200313
UniProtAcc

P40692

Q13439

Ensembl transtripts involved in fusion geneENST00000492474, ENST00000231790, 
ENST00000435176, ENST00000455445, 
ENST00000458205, ENST00000536378, 
ENST00000539477, 		ENST00000361924, 
ENST00000356847, ENST00000435830, 
ENST00000444882, 
Fusion gene scores* DoF score2 X 3 X 2=1214 X 16 X 6=1344
# samples 215
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/1344*10)=-3.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MLH1 [Title/Abstract] AND GOLGA4 [Title/Abstract] AND fusion [Title/Abstract]

An interstitial deletion at 3p21.3 results in the genetic fusion of MLH1 and ITGA9 in a Lynch syndrome family (pmid: 19188145)
Most frequent breakpointGOLGA4(37370584)-MLH1(37089010), # samples:2
GOLGA4(37343823)-MLH1(37058997), # samples:2
GOLGA4(37360685)-MLH1(37061801), # samples:2
MLH1(37050396)-GOLGA4(37376544), # samples:2
Anticipated loss of major functional domain due to fusion event.GOLGA4-MLH1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
GOLGA4-MLH1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
MLH1-GOLGA4 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MLH1-GOLGA4 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGOLGA4

GO:0043001

Golgi to plasma membrane protein transport

15265687

TgeneGOLGA4

GO:0045773

positive regulation of axon extension

22705394


check buttonFusion gene breakpoints across MLH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GOLGA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-EW-A1IZ-01AMLH1chr3

37048554

+GOLGA4chr3

37376544

+
ChimerDB4BRCATCGA-EW-A1IZ-01AMLH1chr3

37050396

+GOLGA4chr3

37376544

+


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Fusion Gene ORF analysis for MLH1-GOLGA4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000492474ENST00000361924MLH1chr3

37048554

+GOLGA4chr3

37376544

+
3UTR-3CDSENST00000492474ENST00000361924MLH1chr3

37050396

+GOLGA4chr3

37376544

+
3UTR-intronENST00000492474ENST00000356847MLH1chr3

37048554

+GOLGA4chr3

37376544

+
3UTR-intronENST00000492474ENST00000356847MLH1chr3

37050396

+GOLGA4chr3

37376544

+
3UTR-intronENST00000492474ENST00000435830MLH1chr3

37048554

+GOLGA4chr3

37376544

+
3UTR-intronENST00000492474ENST00000435830MLH1chr3

37050396

+GOLGA4chr3

37376544

+
3UTR-intronENST00000492474ENST00000444882MLH1chr3

37048554

+GOLGA4chr3

37376544

+
3UTR-intronENST00000492474ENST00000444882MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5CDS-intronENST00000231790ENST00000356847MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5CDS-intronENST00000231790ENST00000356847MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5CDS-intronENST00000231790ENST00000435830MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5CDS-intronENST00000231790ENST00000435830MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5CDS-intronENST00000231790ENST00000444882MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5CDS-intronENST00000231790ENST00000444882MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5CDS-intronENST00000435176ENST00000356847MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5CDS-intronENST00000435176ENST00000356847MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5CDS-intronENST00000435176ENST00000435830MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5CDS-intronENST00000435176ENST00000435830MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5CDS-intronENST00000435176ENST00000444882MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5CDS-intronENST00000435176ENST00000444882MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5UTR-3CDSENST00000455445ENST00000361924MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5UTR-3CDSENST00000455445ENST00000361924MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5UTR-3CDSENST00000458205ENST00000361924MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5UTR-3CDSENST00000458205ENST00000361924MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5UTR-3CDSENST00000536378ENST00000361924MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5UTR-3CDSENST00000536378ENST00000361924MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5UTR-3CDSENST00000539477ENST00000361924MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5UTR-intronENST00000455445ENST00000356847MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5UTR-intronENST00000455445ENST00000356847MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5UTR-intronENST00000455445ENST00000435830MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5UTR-intronENST00000455445ENST00000435830MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5UTR-intronENST00000455445ENST00000444882MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5UTR-intronENST00000455445ENST00000444882MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5UTR-intronENST00000458205ENST00000356847MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5UTR-intronENST00000458205ENST00000356847MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5UTR-intronENST00000458205ENST00000435830MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5UTR-intronENST00000458205ENST00000435830MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5UTR-intronENST00000458205ENST00000444882MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5UTR-intronENST00000458205ENST00000444882MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5UTR-intronENST00000536378ENST00000356847MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5UTR-intronENST00000536378ENST00000356847MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5UTR-intronENST00000536378ENST00000435830MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5UTR-intronENST00000536378ENST00000435830MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5UTR-intronENST00000536378ENST00000444882MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5UTR-intronENST00000536378ENST00000444882MLH1chr3

37050396

+GOLGA4chr3

37376544

+
5UTR-intronENST00000539477ENST00000356847MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5UTR-intronENST00000539477ENST00000435830MLH1chr3

37048554

+GOLGA4chr3

37376544

+
5UTR-intronENST00000539477ENST00000444882MLH1chr3

37048554

+GOLGA4chr3

37376544

+
Frame-shiftENST00000231790ENST00000361924MLH1chr3

37050396

+GOLGA4chr3

37376544

+
Frame-shiftENST00000435176ENST00000361924MLH1chr3

37050396

+GOLGA4chr3

37376544

+
In-frameENST00000231790ENST00000361924MLH1chr3

37048554

+GOLGA4chr3

37376544

+
In-frameENST00000435176ENST00000361924MLH1chr3

37048554

+GOLGA4chr3

37376544

+
intron-3CDSENST00000539477ENST00000361924MLH1chr3

37050396

+GOLGA4chr3

37376544

+
intron-intronENST00000539477ENST00000356847MLH1chr3

37050396

+GOLGA4chr3

37376544

+
intron-intronENST00000539477ENST00000435830MLH1chr3

37050396

+GOLGA4chr3

37376544

+
intron-intronENST00000539477ENST00000444882MLH1chr3

37050396

+GOLGA4chr3

37376544

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000231790MLH1chr337048554+ENST00000361924GOLGA4chr337376544+18756692161169317
ENST00000435176MLH1chr337048554+ENST00000361924GOLGA4chr337376544+1625419260919219

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000231790ENST00000361924MLH1chr337048554+GOLGA4chr337376544+0.0012360180.99876404
ENST00000435176ENST00000361924MLH1chr337048554+GOLGA4chr337376544+0.0004391140.9995609

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Fusion Genomic Features for MLH1-GOLGA4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MLH1-GOLGA4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:37370584/chr3:37089010)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MLH1

P40692

GOLGA4

Q13439

FUNCTION: Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis. {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:20020535, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:9311737}.FUNCTION: Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMLH1chr3:37048554chr3:37376544ENST00000231790+519100_104151757.0Nucleotide bindingATP
HgeneMLH1chr3:37048554chr3:37376544ENST00000231790+51982_84151757.0Nucleotide bindingATP
TgeneGOLGA4chr3:37048554chr3:37376544ENST0000035684716232168_221520862244.0DomainGRIP
TgeneGOLGA4chr3:37048554chr3:37376544ENST0000036192415242168_221520642306.3333333333335DomainGRIP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMLH1chr3:37048554chr3:37376544ENST00000435176+519100_10453659.0Nucleotide bindingATP
HgeneMLH1chr3:37048554chr3:37376544ENST00000435176+51982_8453659.0Nucleotide bindingATP
HgeneMLH1chr3:37048554chr3:37376544ENST00000455445+519100_1040516.0Nucleotide bindingATP
HgeneMLH1chr3:37048554chr3:37376544ENST00000455445+51982_840516.0Nucleotide bindingATP
HgeneMLH1chr3:37048554chr3:37376544ENST00000458205+620100_1040516.0Nucleotide bindingATP
HgeneMLH1chr3:37048554chr3:37376544ENST00000458205+62082_840516.0Nucleotide bindingATP
HgeneMLH1chr3:37048554chr3:37376544ENST00000539477+518100_1040516.0Nucleotide bindingATP
HgeneMLH1chr3:37048554chr3:37376544ENST00000539477+51882_840516.0Nucleotide bindingATP
TgeneGOLGA4chr3:37048554chr3:37376544ENST000003568471623133_218520862244.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGA4chr3:37048554chr3:37376544ENST000003619241524133_218520642306.3333333333335Coiled coilOntology_term=ECO:0000255
TgeneGOLGA4chr3:37048554chr3:37376544ENST000003568471623252_209620862244.0Compositional biasNote=Glu-rich
TgeneGOLGA4chr3:37048554chr3:37376544ENST000003619241524252_209620642306.3333333333335Compositional biasNote=Glu-rich


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Fusion Gene Sequence for MLH1-GOLGA4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54168_54168_1_MLH1-GOLGA4_MLH1_chr3_37048554_ENST00000231790_GOLGA4_chr3_37376544_ENST00000361924_length(transcript)=1875nt_BP=669nt
GCCGCTTCAGGGAGGGACGAAGAGACCCAGCAACCCACAGAGTTGAGAAATTTGACTGGCATTCAAGCTGTCCAATCAATAGCTGCCGCT
GAAGGGTGGGGCTGGATGGCGTAAGCTACAGCTGAAGGAAGAACGTGAGCACGAGGCACTGAGGTGATTGGCTGAAGGCACTTCCGTTGA
GCATCTAGACGTTTCCTTGGCTCTTCTGGCGCCAAAATGTCGTTCGTGGCAGGGGTTATTCGGCGGCTGGACGAGACAGTGGTGAACCGC
ATCGCGGCGGGGGAAGTTATCCAGCGGCCAGCTAATGCTATCAAAGAGATGATTGAGAACTGTTTAGATGCAAAATCCACAAGTATTCAA
GTGATTGTTAAAGAGGGAGGCCTGAAGTTGATTCAGATCCAAGACAATGGCACCGGGATCAGGAAAGAAGATCTGGATATTGTATGTGAA
AGGTTCACTACTAGTAAACTGCAGTCCTTTGAGGATTTAGCCAGTATTTCTACCTATGGCTTTCGAGGTGAGGCTTTGGCCAGCATAAGC
CATGTGGCTCATGTTACTATTACAACGAAAACAGCTGATGGAAAGTGTGCATACAGAGCAAGTTACTCAGATGGAAAACTGAAAGCCCCT
CCTAAACCATGTGCTGGCAATCAAGGGACCCAGATCACGGCTCGTGAAGAAGAAATGACTGCAAAAGTAAGGGACCTGCAGACTCAACTT
GAGGAGCTGCAGAAGAAATACCAGCAAAAGCTAGAGCAGGAGGAGAACCCTGGCAATGATAATGTAACAATTATGGAGCTACAGACACAG
CTAGCACAGAAGACGACTTTAATCAGTGATTCGAAATTGAAAGAGCAAGAGTTCAGAGAACAGATTCACAATTTAGAAGACCGTTTGAAG
AAATATGAAAAGAATGTATATGCAACAACTGTGGGGACACCTTACAAAGGTGGCAATTTGTACCATACGGATGTCTCACTCTTTGGAGAA
CCTACCGAATTTGAGTATTTGCGAAAAGTGCTTTTTGAGTATATGATGGGTCGTGAGACTAAGACCATGGCAAAAGTTATAACCACCGTA
CTGAAGTTCCCTGATGATCAGACTCAGAAAATTTTGGAAAGAGAAGATGCTCGGCTGATGTTTACTTCACCTCGCAGTGGTATCTTCTGA
GTAAACCATCAGTCTGTGCTTAGTTAACATGTGTCATGGCTCCGATCTTCATCTTGAAGAAGAGTGACATTGGGTGACTGCTGCTTGGAA
AACTGTCCACACTTGCTACTCTTTGAGAATGAAGTTGTCATTCAGGGCCCCTCATGTAGCCAAAAGACCAAGAAAAATCTGGCCCACAGA
TAAGTTGCAGACTGCCTTTAAAATAGATTTTATCAGTGGAGAAATGGTGATAGTTTTTTCTTCAGTTTTCTCTTGGGAAGAGTTTTATGT
TGTTTAAAAGATATTTTGATAACTTAACCTGCTTTATGGGCTTACATAATATTCCTTTCATCCATTCTTTTTAAAGAACGGCTTACCTTT
CCTATTTATTTTTAGGGTGATTTTTTAAAAAGACTTGTGCAATACATTTTGAGGTGAAACTTAGTGGATTTTTTCTGATAAATTAGAGCA
TTTAATTGACTATTTTATTCAGGTTGATCTGTTGAATATTTGCTAAAGACCAGTTCTTTAAGCTAAGACATGTAAAAAATCCCAAATGGC
AGTACCTCATTGTTTACTTAGCTTTTGTACTTATATTTTTCAGAGGAAAAAACACTACTGTAAATTGTGAATAGCCAATACATAACTGTA

>54168_54168_1_MLH1-GOLGA4_MLH1_chr3_37048554_ENST00000231790_GOLGA4_chr3_37376544_ENST00000361924_length(amino acids)=317AA_BP=0
MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFED
LASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITAREEEMTAKVRDLQTQLEELQKKYQQKLE
QEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVLF

--------------------------------------------------------------
>54168_54168_2_MLH1-GOLGA4_MLH1_chr3_37048554_ENST00000435176_GOLGA4_chr3_37376544_ENST00000361924_length(transcript)=1625nt_BP=419nt
GACGTGCCAGTCAGGCCTTCTCCTTTTCCGCAGACCGTGTGTTTCTTTACCGCTCTCCCCCGAGACCTTTTAAGGGTTGTTTGGAGTTTT
AGATGCAAAATCCACAAGTATTCAAGTGATTGTTAAAGAGGGAGGCCTGAAGTTGATTCAGATCCAAGACAATGGCACCGGGATCAGGAA
AGAAGATCTGGATATTGTATGTGAAAGGTTCACTACTAGTAAACTGCAGTCCTTTGAGGATTTAGCCAGTATTTCTACCTATGGCTTTCG
AGGCTTTGGCCAGCATAAGCCATGTGGCTCATGTTACTATTACAACGAAAACAGCTGATGGAAAGTGTGCATACAGAGCAAGTTACTCAG
ATGGAAAACTGAAAGCCCCTCCTAAACCATGTGCTGGCAATCAAGGGACCCAGATCACGGCTCGTGAAGAAGAAATGACTGCAAAAGTAA
GGGACCTGCAGACTCAACTTGAGGAGCTGCAGAAGAAATACCAGCAAAAGCTAGAGCAGGAGGAGAACCCTGGCAATGATAATGTAACAA
TTATGGAGCTACAGACACAGCTAGCACAGAAGACGACTTTAATCAGTGATTCGAAATTGAAAGAGCAAGAGTTCAGAGAACAGATTCACA
ATTTAGAAGACCGTTTGAAGAAATATGAAAAGAATGTATATGCAACAACTGTGGGGACACCTTACAAAGGTGGCAATTTGTACCATACGG
ATGTCTCACTCTTTGGAGAACCTACCGAATTTGAGTATTTGCGAAAAGTGCTTTTTGAGTATATGATGGGTCGTGAGACTAAGACCATGG
CAAAAGTTATAACCACCGTACTGAAGTTCCCTGATGATCAGACTCAGAAAATTTTGGAAAGAGAAGATGCTCGGCTGATGTTTACTTCAC
CTCGCAGTGGTATCTTCTGAGTAAACCATCAGTCTGTGCTTAGTTAACATGTGTCATGGCTCCGATCTTCATCTTGAAGAAGAGTGACAT
TGGGTGACTGCTGCTTGGAAAACTGTCCACACTTGCTACTCTTTGAGAATGAAGTTGTCATTCAGGGCCCCTCATGTAGCCAAAAGACCA
AGAAAAATCTGGCCCACAGATAAGTTGCAGACTGCCTTTAAAATAGATTTTATCAGTGGAGAAATGGTGATAGTTTTTTCTTCAGTTTTC
TCTTGGGAAGAGTTTTATGTTGTTTAAAAGATATTTTGATAACTTAACCTGCTTTATGGGCTTACATAATATTCCTTTCATCCATTCTTT
TTAAAGAACGGCTTACCTTTCCTATTTATTTTTAGGGTGATTTTTTAAAAAGACTTGTGCAATACATTTTGAGGTGAAACTTAGTGGATT
TTTTCTGATAAATTAGAGCATTTAATTGACTATTTTATTCAGGTTGATCTGTTGAATATTTGCTAAAGACCAGTTCTTTAAGCTAAGACA
TGTAAAAAATCCCAAATGGCAGTACCTCATTGTTTACTTAGCTTTTGTACTTATATTTTTCAGAGGAAAAAACACTACTGTAAATTGTGA
ATAGCCAATACATAACTGTATTGTATGCAAATCTGTGATTGTTGGCAGTGTCATCTCTGAGAAACAGATAAATAAAGTTTATTTACTATA

>54168_54168_2_MLH1-GOLGA4_MLH1_chr3_37048554_ENST00000435176_GOLGA4_chr3_37376544_ENST00000361924_length(amino acids)=219AA_BP=4
MAFEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGND
NVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVLFEYMMGRET

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Fusion Gene PPI Analysis for MLH1-GOLGA4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMLH1chr3:37048554chr3:37376544ENST00000231790+519410_650151.0757.0EXO1
HgeneMLH1chr3:37048554chr3:37376544ENST00000435176+519410_65053.0659.0EXO1
HgeneMLH1chr3:37048554chr3:37376544ENST00000455445+519410_6500516.0EXO1
HgeneMLH1chr3:37048554chr3:37376544ENST00000458205+620410_6500516.0EXO1
HgeneMLH1chr3:37048554chr3:37376544ENST00000539477+518410_6500516.0EXO1
TgeneGOLGA4chr3:37048554chr3:37376544ENST000003568471623133_2032086.02244.0MACF1
TgeneGOLGA4chr3:37048554chr3:37376544ENST000003619241524133_2032064.02306.3333333333335MACF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MLH1-GOLGA4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MLH1-GOLGA4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource