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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:API5-LCMT1 (FusionGDB2 ID:5423)

Fusion Gene Summary for API5-LCMT1

Fusion gene summary

Fusion gene information	Fusion gene name: API5-LCMT1
	Fusion gene ID: 5423
		Hgene	Tgene
	Gene symbol	API5	LCMT1
	Gene ID	8539	51451
	Gene name	apoptosis inhibitor 5	leucine carboxyl methyltransferase 1
	Synonyms	AAC-11\|AAC11	CGI-68\|LCMT\|PPMT1
	Cytomap	11p12	16p12.1
	Type of gene	protein-coding	protein-coding
	Description	apoptosis inhibitor 5FIFantiapoptosis clone 11 proteincell migration-inducing gene 8 proteinfibroblast growth factor 2-interacting factor 2migration-inducing protein MIG8	leucine carboxyl methyltransferase 1[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1protein phosphatase methyltransferase 1protein-leucine O-methyltransferase
	Modification date	20200313	20200313
	UniProtAcc	Q9BZZ5	Q9UIC8
	Ensembl transtripts involved in fusion gene	ENST00000529334, ENST00000378852, ENST00000420461, ENST00000455725, ENST00000531273, ENST00000534600, ENST00000534695,	ENST00000399069, ENST00000572869, ENST00000380966,
Fusion gene scores	* DoF score	7 X 5 X 5=175	5 X 7 X 4=140
	# samples	7	6
	** MAII score	log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/140*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: API5 [Title/Abstract] AND LCMT1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	API5(43357544)-LCMT1(25172422), # samples:2
Anticipated loss of major functional domain due to fusion event.	API5-LCMT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. API5-LCMT1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. API5-LCMT1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	LCMT1	GO:0006481	C-terminal protein methylation	10600115

Fusion gene breakpoints across API5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LCMT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A4OQ	API5	chr11	43357544	+	LCMT1	chr16	25172422	+

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Fusion Gene ORF analysis for API5-LCMT1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000529334	ENST00000399069	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
3UTR-3UTR	ENST00000529334	ENST00000572869	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
3UTR-intron	ENST00000529334	ENST00000380966	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
5CDS-3UTR	ENST00000378852	ENST00000572869	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
5CDS-3UTR	ENST00000420461	ENST00000572869	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
5CDS-3UTR	ENST00000455725	ENST00000572869	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
5CDS-3UTR	ENST00000531273	ENST00000572869	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
5CDS-3UTR	ENST00000534600	ENST00000572869	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
5CDS-intron	ENST00000378852	ENST00000380966	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
5CDS-intron	ENST00000420461	ENST00000380966	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
5CDS-intron	ENST00000455725	ENST00000380966	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
5CDS-intron	ENST00000531273	ENST00000380966	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
5CDS-intron	ENST00000534600	ENST00000380966	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
Frame-shift	ENST00000534600	ENST00000399069	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
In-frame	ENST00000378852	ENST00000399069	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
In-frame	ENST00000420461	ENST00000399069	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
In-frame	ENST00000455725	ENST00000399069	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
In-frame	ENST00000531273	ENST00000399069	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
intron-3CDS	ENST00000534695	ENST00000399069	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
intron-3UTR	ENST00000534695	ENST00000572869	API5	chr11	43357544	+	LCMT1	chr16	25172422	+
intron-intron	ENST00000534695	ENST00000380966	API5	chr11	43357544	+	LCMT1	chr16	25172422	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000455725

API5

chr11

43357544

ENST00000399069

LCMT1

chr16

25172422

2451

1704

245

2242

665

ENST00000531273

API5

chr11

43357544

ENST00000399069

LCMT1

chr16

25172422

2378

1631

121

2169

682

ENST00000420461

API5

chr11

43357544

ENST00000399069

LCMT1

chr16

25172422

2207

1460

112

1998

628

ENST00000378852

API5

chr11

43357544

ENST00000399069

LCMT1

chr16

25172422

2364

1617

107

2155

682

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000455725	ENST00000399069	API5	chr11	43357544	+	LCMT1	chr16	25172422	+	0.00383781	0.9961622
ENST00000531273	ENST00000399069	API5	chr11	43357544	+	LCMT1	chr16	25172422	+	0.002048279	0.9979518
ENST00000420461	ENST00000399069	API5	chr11	43357544	+	LCMT1	chr16	25172422	+	0.002047089	0.99795294
ENST00000378852	ENST00000399069	API5	chr11	43357544	+	LCMT1	chr16	25172422	+	0.002078286	0.99792176

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Fusion Genomic Features for API5-LCMT1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
API5	chr11	43357544	+	LCMT1	chr16	25172422	+	0.000441325	0.9995586
API5	chr11	43357544	+	LCMT1	chr16	25172422	+	0.000441325	0.9995586

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for API5-LCMT1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:43357544/chr16:25172422)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
API5 Q9BZZ5	LCMT1 Q9UIC8
FUNCTION: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. {ECO:0000269\|PubMed:10780674, ECO:0000269\|PubMed:17112319, ECO:0000269\|PubMed:19387494}.	FUNCTION: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. {ECO:0000269\|PubMed:10600115}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

API5

chr11:43357544

chr16:25172422

ENST00000378852

454_475

497

505.0

Motif

Nuclear localization signal

Hgene

API5

chr11:43357544

chr16:25172422

ENST00000531273

454_475

497

525.0

Motif

Nuclear localization signal

Hgene

API5

chr11:43357544

chr16:25172422

ENST00000378852

2_360

497

505.0

Region

Note=ARM-like and Heat-like helical repeats

Hgene

API5

chr11:43357544

chr16:25172422

ENST00000378852

370_391

497

505.0

Region

Note=Leucine-zipper

Hgene

API5

chr11:43357544

chr16:25172422

ENST00000420461

2_360

443

451.0

Region

Note=ARM-like and Heat-like helical repeats

Hgene

API5

chr11:43357544

chr16:25172422

ENST00000420461

370_391

443

451.0

Region

Note=Leucine-zipper

Hgene

API5

chr11:43357544

chr16:25172422

ENST00000531273

2_360

497

525.0

Region

Note=ARM-like and Heat-like helical repeats

Hgene

API5

chr11:43357544

chr16:25172422

ENST00000531273

370_391

497

525.0

Region

Note=Leucine-zipper

Tgene

LCMT1

chr11:43357544

chr16:25172422

ENST00000380966

171_172

280.0

Region

S-adenosyl-L-methionine binding

Tgene

LCMT1

chr11:43357544

chr16:25172422

ENST00000399069

171_172

155

335.0

Region

S-adenosyl-L-methionine binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

API5

chr11:43357544

chr16:25172422

ENST00000420461

454_475

443

451.0

Motif

Nuclear localization signal

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Fusion Gene Sequence for API5-LCMT1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>5423_5423_1_API5-LCMT1_API5_chr11_43357544_ENST00000378852_LCMT1_chr16_25172422_ENST00000399069_length(transcript)=2364nt_BP=1617nt
GCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGGCGGCGGTGGCGCCGGTCAGGACAAG
GATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCTGGCCGATGCCACGG
AGCAAGTGGGCCAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATTAGCAGCTCAATTTA
TTCCGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGAAGATGTATCTATTC
GACGTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCAACTTTTGCAGACAG
ATGACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGGTGGGTTGTTCAGCC
AAATACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGATGAAGTCTTAACAA
AGGAAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGTCCTAGAAGATGTGACTGGTGAAGAATTTGTTCTATTTATGAAGATACTGT
CTGGGTTAAAAAGCTTACAGACAGTGAGTGGAAGACAGCAACTTGTAGAGTTGGTGGCTGAACAGGCCGACCTAGAACAGACCTTCAATC
CCTCGGATCCTGACTGTGTGGACAGGCTCTTACAGTGCACTCGGCAGGCAGTACCCCTCTTCTCTAAAAATGTCCATTCCACAAGGTTTG
TGACATATTTCTGTGAGCAGGTTCTCCCTAACCTCGGTACCTTGACTACCCCAGTGGAAGGTCTTGATATACAGTTGGAGGTATTGAAAT
TGTTGGCGGAGATGAGTTCATTTTGTGGTGACATGGAAAAACTAGAAACAAATTTAAGGAAACTATTTGATAAGTTATTGGAATACATGC
CCCTCCCTCCAGAAGAGGCAGAAAATGGAGAGAATGCTGGTAATGAAGAACCCAAGCTACAGTTCAGTTATGTGGAATGTTTGTTGTACA
GTTTTCACCAGTTGGGCCGAAAACTTCCAGATTTCTTAACAGCCAAACTGAATGCAGAAAAGCTCAAAGATTTCAAAATCAGGCTGCAGT
ACTTTGCACGGGGCCTGCAAGTTTATATCAGACAACTTCGCTTAGCTCTCCAGGGTAAAACGGGTGAGGCCTTAAAAACAGAAGAGAACA
AGATTAAAGTCGTTGCATTGAAAATAACAAACAATATCAATGTTTTAATCAAGGATCTCTTCCACATTCCTCCTTCTTATAAGAGCACAG
TAACACTATCCTGGAAACCTGTACAAAAGGTTGAGATTGGGCAAAAGAGAGCCAGTGAAGATACAACTTCAGGTTCACCACCCAAGAAAT
CTTCAGCAGGACCAAAAAGAGATGCCAGGCAGATTTATAACCCTCCCAGTGGGAAATATAGCAGCAATTTGGGCAACTTTAATTATGATG
GACACATACTGGATTCAAAGAGATATGCCGTTATTGGAGCAGATCTCCGAGACCTGTCTGAACTGGAAGAGAAGCTAAAGAAATGTAACA
TGAATACACAATTGCCAACACTCCTGATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAG
CCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATGATTGAAAACCTGCGGA
GACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCAT
CGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTGGATGAAATGGAGC
TGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAGCTTGGGCTGAAGGAGATAACTTATTAATCTG
TCGAAGGCTTATGCCGAGCCAGAAGCCGAAGCCACTTGCCCTCCTGGAGGAGACCTGCAAGCTCCCTGAGCGGTGGGCGGGCCTCGTCCG
CAGGTCTCATCCCACACTCTTGAGAAGCCTTGGTCACTACAGTGGTCGCACATGTTCCTCTTCCTGTTCCTGTTGACATGTCGTTGTTTA

>5423_5423_1_API5-LCMT1_API5_chr11_43357544_ENST00000378852_LCMT1_chr16_25172422_ENST00000399069_length(amino acids)=682AA_BP=503
MGLSLTMPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIK
ELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEEL
ILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCE
QVLPNLGTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLG
RKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWK
PVQKVEIGQKRASEDTTSGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYDGHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLP
TLLIAECVLVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLSNGWETASAVDMM

--------------------------------------------------------------
>5423_5423_2_API5-LCMT1_API5_chr11_43357544_ENST00000420461_LCMT1_chr16_25172422_ENST00000399069_length(transcript)=2207nt_BP=1460nt
GACTGGCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGGCGGCGGTGGCGCCGGTCAGG
ACAAGGATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCTGGCCGATGC
CACGGAGCAAGTGGGCCAGATTCGACGTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATAT
ACTAACGCAACTTTTGCAGACAGATGACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGG
GACTTTAGGTGGGTTGTTCAGCCAAATACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGAC
TTTACCAGATGAAGTCTTAACAAAGGAAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGTCCTAGAAGATGTGACTGGTGAAGAATT
TGTTCTATTTATGAAGATACTGTCTGGGTTAAAAAGCTTACAGACAGTGAGTGGAAGACAGCAACTTGTAGAGTTGGTGGCTGAACAGGC
CGACCTAGAACAGACCTTCAATCCCTCGGATCCTGACTGTGTGGACAGGCTCTTACAGTGCACTCGGCAGGCAGTACCCCTCTTCTCTAA
AAATGTCCATTCCACAAGGTTTGTGACATATTTCTGTGAGCAGGTTCTCCCTAACCTCGGTACCTTGACTACCCCAGTGGAAGGTCTTGA
TATACAGTTGGAGGTATTGAAATTGTTGGCGGAGATGAGTTCATTTTGTGGTGACATGGAAAAACTAGAAACAAATTTAAGGAAACTATT
TGATAAGTTATTGGAATACATGCCCCTCCCTCCAGAAGAGGCAGAAAATGGAGAGAATGCTGGTAATGAAGAACCCAAGCTACAGTTCAG
TTATGTGGAATGTTTGTTGTACAGTTTTCACCAGTTGGGCCGAAAACTTCCAGATTTCTTAACAGCCAAACTGAATGCAGAAAAGCTCAA
AGATTTCAAAATCAGGCTGCAGTACTTTGCACGGGGCCTGCAAGTTTATATCAGACAACTTCGCTTAGCTCTCCAGGGTAAAACGGGTGA
GGCCTTAAAAACAGAAGAGAACAAGATTAAAGTCGTTGCATTGAAAATAACAAACAATATCAATGTTTTAATCAAGGATCTCTTCCACAT
TCCTCCTTCTTATAAGAGCACAGTAACACTATCCTGGAAACCTGTACAAAAGGTTGAGATTGGGCAAAAGAGAGCCAGTGAAGATACAAC
TTCAGGTTCACCACCCAAGAAATCTTCAGCAGGACCAAAAAGAGATGCCAGGCAGATTTATAACCCTCCCAGTGGGAAATATAGCAGCAA
TTTGGGCAACTTTAATTATGATGGACACATACTGGATTCAAAGAGATATGCCGTTATTGGAGCAGATCTCCGAGACCTGTCTGAACTGGA
AGAGAAGCTAAAGAAATGTAACATGAATACACAATTGCCAACACTCCTGATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTC
CGCAAACCTCCTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCA
GATCATGATTGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCT
GTCGAATGGGTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACT
TGAATTCCTGGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAGCTTGGGCT
GAAGGAGATAACTTATTAATCTGTCGAAGGCTTATGCCGAGCCAGAAGCCGAAGCCACTTGCCCTCCTGGAGGAGACCTGCAAGCTCCCT
GAGCGGTGGGCGGGCCTCGTCCGCAGGTCTCATCCCACACTCTTGAGAAGCCTTGGTCACTACAGTGGTCGCACATGTTCCTCTTCCTGT

>5423_5423_2_API5-LCMT1_API5_chr11_43357544_ENST00000420461_LCMT1_chr16_25172422_ENST00000399069_length(amino acids)=628AA_BP=449
MGLSLTMPTVEELYRNYGILADATEQVGQIRRQAIKELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFS
QILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFN
PSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLGTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYM
PLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEEN
KIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVEIGQKRASEDTTSGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYD
GHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLPTLLIAECVLVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLR

--------------------------------------------------------------
>5423_5423_3_API5-LCMT1_API5_chr11_43357544_ENST00000455725_LCMT1_chr16_25172422_ENST00000399069_length(transcript)=2451nt_BP=1704nt
GCAGCCGCGCTGTGCGCGGTGACTGGCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGG
CGGCGGTGGCGCCGGTCAGGACAAGGATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAAT
TATGGCATCCTGGCCGATGCCACGGAGCAAGTGGGCCAGACTCATCCATCTCCCCCAACTCAAAAATGAAACAAAGATGGAGGGAGAACG
GAATTGGGAAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATTAGCAGCTCAATTTATTC
CGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGAAGATGTATCTATTCGAC
GTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCAACTTTTGCAGACAGATG
ACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGGTGGGTTGTTCAGCCAAA
TACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGATGAAGTCTTAACAAAGG
AAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGTCCTAGAAGATGTGACTGGTGAAGAATTTGTTCTATTTATGAAGATACTGTCTG
GGTTAAAAAGCTTACAGACAGTGAGTGGAAGACAGCAACTTGTAGAGTTGGTGGCTGAACAGGCCGACCTAGAACAGACCTTCAATCCCT
CGGATCCTGACTGTGTGGACAGGCTCTTACAGTGCACTCGGCAGGCAGTACCCCTCTTCTCTAAAAATGTCCATTCCACAAGGTTTGTGA
CATATTTCTGTGAGCAGGTTCTCCCTAACCTCGGTACCTTGACTACCCCAGTGGAAGGTCTTGATATACAGTTGGAGGTATTGAAATTGT
TGGCGGAGATGAGTTCATTTTGTGGTGACATGGAAAAACTAGAAACAAATTTAAGGAAACTATTTGATAAGTTATTGGAATACATGCCCC
TCCCTCCAGAAGAGGCAGAAAATGGAGAGAATGCTGGTAATGAAGAACCCAAGCTACAGTTCAGTTATGTGGAATGTTTGTTGTACAGTT
TTCACCAGTTGGGCCGAAAACTTCCAGATTTCTTAACAGCCAAACTGAATGCAGAAAAGCTCAAAGATTTCAAAATCAGGCTGCAGTACT
TTGCACGGGGCCTGCAAGTTTATATCAGACAACTTCGCTTAGCTCTCCAGGGTAAAACGGGTGAGGCCTTAAAAACAGAAGAGAACAAGA
TTAAAGTCGTTGCATTGAAAATAACAAACAATATCAATGTTTTAATCAAGGATCTCTTCCACATTCCTCCTTCTTATAAGAGCACAGTAA
CACTATCCTGGAAACCTGTACAAAAGGTTGAGATTGGGCAAAAGAGAGCCAGTGAAGATACAACTTCAGGTTCACCACCCAAGAAATCTT
CAGCAGGACCAAAAAGAGATGCCAGGCAGATTTATAACCCTCCCAGTGGGAAATATAGCAGCAATTTGGGCAACTTTAATTATGATGGAC
ACATACTGGATTCAAAGAGATATGCCGTTATTGGAGCAGATCTCCGAGACCTGTCTGAACTGGAAGAGAAGCTAAAGAAATGTAACATGA
ATACACAATTGCCAACACTCCTGATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCTCCTGAAGTGGGCAGCCA
ACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATGATTGAAAACCTGCGGAGAC
GCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGGGTGGGAAACAGCATCGG
CCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTCCTGGATGAAATGGAGCTGC
TGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAGCTTGGGCTGAAGGAGATAACTTATTAATCTGTCG
AAGGCTTATGCCGAGCCAGAAGCCGAAGCCACTTGCCCTCCTGGAGGAGACCTGCAAGCTCCCTGAGCGGTGGGCGGGCCTCGTCCGCAG
GTCTCATCCCACACTCTTGAGAAGCCTTGGTCACTACAGTGGTCGCACATGTTCCTCTTCCTGTTCCTGTTGACATGTCGTTGTTTAAAT

>5423_5423_3_API5-LCMT1_API5_chr11_43357544_ENST00000455725_LCMT1_chr16_25172422_ENST00000399069_length(amino acids)=665AA_BP=486
MKQRWRENGIGKHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGENLPRVADI
LTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKVLEDVTGEEF
VLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLGTLTTPVEGLD
IQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLK
DFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVEIGQKRASEDTT
SGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYDGHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLPTLLIAECVLVYMTPEQS
ANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLSNGWETASAVDMMELYNRLPRAEVSRIESL

--------------------------------------------------------------
>5423_5423_4_API5-LCMT1_API5_chr11_43357544_ENST00000531273_LCMT1_chr16_25172422_ENST00000399069_length(transcript)=2378nt_BP=1631nt
GTGCGCGGTGACTGGCGGCTGCACTGGCGGCAGCTGGAGGTGTAATAGTGCGGGTAGTGGGTTTGGAGAAGTTCCGAGGCGGCGGTGGCG
CCGGTCAGGACAAGGATAGCGGAACCGGGCCCTGGGCTTGTCGCTCACCATGCCGACAGTAGAGGAGCTTTACCGCAATTATGGCATCCT
GGCCGATGCCACGGAGCAAGTGGGCCAGCATAAAGATGCCTATCAAGTGATATTGGATGGTGTGAAAGGTGGTACTAAGGAAAAGCGATT
AGCAGCTCAATTTATTCCGAAATTCTTTAAGCATTTTCCAGAATTGGCTGATTCTGCTATCAATGCACAGTTAGACCTCTGTGAGGATGA
AGATGTATCTATTCGACGTCAAGCAATTAAAGAACTGCCTCAATTTGCCACTGGAGAAAATCTTCCTCGAGTGGCAGATATACTAACGCA
ACTTTTGCAGACAGATGACTCTGCAGAATTTAACCTAGTGAACAATGCCCTATTAAGTATATTTAAAATGGATGCAAAAGGGACTTTAGG
TGGGTTGTTCAGCCAAATACTTCAAGGAGAGGACATTGTTAGAGAACGAGCAATTAAATTCCTTTCTACAAAACTTAAGACTTTACCAGA
TGAAGTCTTAACAAAGGAAGTGGAAGAGCTTATACTAACTGAATCCAAAAAGGTCCTAGAAGATGTGACTGGTGAAGAATTTGTTCTATT
TATGAAGATACTGTCTGGGTTAAAAAGCTTACAGACAGTGAGTGGAAGACAGCAACTTGTAGAGTTGGTGGCTGAACAGGCCGACCTAGA
ACAGACCTTCAATCCCTCGGATCCTGACTGTGTGGACAGGCTCTTACAGTGCACTCGGCAGGCAGTACCCCTCTTCTCTAAAAATGTCCA
TTCCACAAGGTTTGTGACATATTTCTGTGAGCAGGTTCTCCCTAACCTCGGTACCTTGACTACCCCAGTGGAAGGTCTTGATATACAGTT
GGAGGTATTGAAATTGTTGGCGGAGATGAGTTCATTTTGTGGTGACATGGAAAAACTAGAAACAAATTTAAGGAAACTATTTGATAAGTT
ATTGGAATACATGCCCCTCCCTCCAGAAGAGGCAGAAAATGGAGAGAATGCTGGTAATGAAGAACCCAAGCTACAGTTCAGTTATGTGGA
ATGTTTGTTGTACAGTTTTCACCAGTTGGGCCGAAAACTTCCAGATTTCTTAACAGCCAAACTGAATGCAGAAAAGCTCAAAGATTTCAA
AATCAGGCTGCAGTACTTTGCACGGGGCCTGCAAGTTTATATCAGACAACTTCGCTTAGCTCTCCAGGGTAAAACGGGTGAGGCCTTAAA
AACAGAAGAGAACAAGATTAAAGTCGTTGCATTGAAAATAACAAACAATATCAATGTTTTAATCAAGGATCTCTTCCACATTCCTCCTTC
TTATAAGAGCACAGTAACACTATCCTGGAAACCTGTACAAAAGGTTGAGATTGGGCAAAAGAGAGCCAGTGAAGATACAACTTCAGGTTC
ACCACCCAAGAAATCTTCAGCAGGACCAAAAAGAGATGCCAGGCAGATTTATAACCCTCCCAGTGGGAAATATAGCAGCAATTTGGGCAA
CTTTAATTATGATGGACACATACTGGATTCAAAGAGATATGCCGTTATTGGAGCAGATCTCCGAGACCTGTCTGAACTGGAAGAGAAGCT
AAAGAAATGTAACATGAATACACAATTGCCAACACTCCTGATAGCTGAATGTGTGCTGGTTTACATGACTCCAGAGCAGTCCGCAAACCT
CCTGAAGTGGGCAGCCAACAGTTTTGAGAGAGCCATGTTCATAAACTACGAACAGGTGAACATGGGTGATCGGTTTGGGCAGATCATGAT
TGAAAACCTGCGGAGACGCCAGTGTGACCTGGCGGGAGTGGAGACCTGCAAGTCATTAGAGTCACAGAAAGAACGGCTCCTGTCGAATGG
GTGGGAAACAGCATCGGCCGTCGACATGATGGAGTTGTACAACAGGTTACCTCGAGCTGAAGTGAGCAGGATAGAATCACTTGAATTCCT
GGATGAAATGGAGCTGCTGGAGCAGCTCATGCGGCATTACTGCCTTTGCTGGGCAACCAAAGGAGGAAATGAGCTTGGGCTGAAGGAGAT
AACTTATTAATCTGTCGAAGGCTTATGCCGAGCCAGAAGCCGAAGCCACTTGCCCTCCTGGAGGAGACCTGCAAGCTCCCTGAGCGGTGG
GCGGGCCTCGTCCGCAGGTCTCATCCCACACTCTTGAGAAGCCTTGGTCACTACAGTGGTCGCACATGTTCCTCTTCCTGTTCCTGTTGA

>5423_5423_4_API5-LCMT1_API5_chr11_43357544_ENST00000531273_LCMT1_chr16_25172422_ENST00000399069_length(amino acids)=682AA_BP=503
MGLSLTMPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIK
ELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEEL
ILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCE
QVLPNLGTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLG
RKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWK
PVQKVEIGQKRASEDTTSGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYDGHILDSKRYAVIGADLRDLSELEEKLKKCNMNTQLP
TLLIAECVLVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLSNGWETASAVDMM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for API5-LCMT1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for API5-LCMT1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for API5-LCMT1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source