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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MLLT10-CYTH1 (FusionGDB2 ID:54257)

Fusion Gene Summary for MLLT10-CYTH1

Fusion gene summary

Fusion gene information	Fusion gene name: MLLT10-CYTH1
	Fusion gene ID: 54257
		Hgene	Tgene
	Gene symbol	MLLT10	CYTH1
	Gene ID	8028	9267
	Gene name	MLLT10 histone lysine methyltransferase DOT1L cofactor	cytohesin 1
	Synonyms	AF10	B2-1\|CYTOHESIN-1\|D17S811E\|PSCD1\|SEC7
	Cytomap	10p12.31	17q25.3
	Type of gene	protein-coding	protein-coding
	Description	protein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 prot	cytohesin-1PH, SEC7 and coiled-coil domain-containing protein 1SEC7 homolog B2-1cytoadhesin 1homolog of secretory protein SEC7pleckstrin homology, Sec7 and coiled-coil domains 1
	Modification date	20200313	20200313
	UniProtAcc	P55197	Q15438
	Ensembl transtripts involved in fusion gene	ENST00000307729, ENST00000377059, ENST00000377072, ENST00000377091, ENST00000377100, ENST00000446906, ENST00000495130,	ENST00000361101, ENST00000446868, ENST00000585509, ENST00000586175, ENST00000589296, ENST00000589297, ENST00000591455,
Fusion gene scores	* DoF score	18 X 15 X 10=2700	6 X 5 X 2=60
	# samples	24	6
	** MAII score	log2(24/2700*10)=-3.49185309632968 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/60*10)=0
Context	PubMed: MLLT10 [Title/Abstract] AND CYTH1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MLLT10(21983195)-CYTH1(76705733), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MLLT10	GO:0045944	positive regulation of transcription by RNA polymerase II	17868029
Tgene	CYTH1	GO:0030155	regulation of cell adhesion	12606567

Fusion gene breakpoints across MLLT10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CYTH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AW381251	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+

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Fusion Gene ORF analysis for MLLT10-CYTH1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000307729	ENST00000361101	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000307729	ENST00000446868	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000307729	ENST00000585509	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000307729	ENST00000586175	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000307729	ENST00000589296	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000307729	ENST00000589297	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000307729	ENST00000591455	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377059	ENST00000361101	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377059	ENST00000446868	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377059	ENST00000585509	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377059	ENST00000586175	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377059	ENST00000589296	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377059	ENST00000589297	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377059	ENST00000591455	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377072	ENST00000361101	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377072	ENST00000446868	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377072	ENST00000585509	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377072	ENST00000586175	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377072	ENST00000589296	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377072	ENST00000589297	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377072	ENST00000591455	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377091	ENST00000361101	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377091	ENST00000446868	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377091	ENST00000585509	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377091	ENST00000586175	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377091	ENST00000589296	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377091	ENST00000589297	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377091	ENST00000591455	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377100	ENST00000361101	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377100	ENST00000446868	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377100	ENST00000585509	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377100	ENST00000586175	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377100	ENST00000589296	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377100	ENST00000589297	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000377100	ENST00000591455	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000446906	ENST00000361101	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000446906	ENST00000446868	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000446906	ENST00000585509	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000446906	ENST00000586175	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000446906	ENST00000589296	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000446906	ENST00000589297	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000446906	ENST00000591455	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000495130	ENST00000361101	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000495130	ENST00000446868	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000495130	ENST00000585509	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000495130	ENST00000586175	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000495130	ENST00000589296	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000495130	ENST00000589297	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+
intron-intron	ENST00000495130	ENST00000591455	MLLT10	chr10	21983195	-	CYTH1	chr17	76705733	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for MLLT10-CYTH1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MLLT10-CYTH1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:21983195/:76705733)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MLLT10 P55197	CYTH1 Q15438
FUNCTION: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269\|PubMed:17868029, ECO:0000269\|PubMed:26439302}.	FUNCTION: Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. {ECO:0000250\|UniProtKB:Q9QX11, ECO:0000269\|PubMed:10652308, ECO:0000269\|PubMed:29420262, ECO:0000269\|PubMed:9653114}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for MLLT10-CYTH1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MLLT10-CYTH1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MLLT10-CYTH1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MLLT10-CYTH1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source