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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MLLT10-DNAJC1 (FusionGDB2 ID:54258)

Fusion Gene Summary for MLLT10-DNAJC1

Fusion gene summary

Fusion gene information	Fusion gene name: MLLT10-DNAJC1
	Fusion gene ID: 54258
		Hgene	Tgene
	Gene symbol	MLLT10	DNAJC1
	Gene ID	8028	64215
	Gene name	MLLT10 histone lysine methyltransferase DOT1L cofactor	DnaJ heat shock protein family (Hsp40) member C1
	Synonyms	AF10	DNAJL1\|ERdj1\|HTJ1\|MTJ1
	Cytomap	10p12.31	10p12.31
	Type of gene	protein-coding	protein-coding
	Description	protein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 prot	dnaJ homolog subfamily C member 1DnaJ (Hsp40) homolog, subfamily C, member 1DnaJ-like proteindnaJ protein homolog MTJ1
	Modification date	20200313	20200313
	UniProtAcc	P55197	Q96DA6
	Ensembl transtripts involved in fusion gene	ENST00000307729, ENST00000377059, ENST00000377072, ENST00000446906, ENST00000377091, ENST00000377100, ENST00000495130,	ENST00000376946, ENST00000483085, ENST00000376980,
Fusion gene scores	* DoF score	18 X 15 X 10=2700	12 X 9 X 6=648
	# samples	24	13
	** MAII score	log2(24/2700*10)=-3.49185309632968 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/648*10)=-2.31748218985617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MLLT10 [Title/Abstract] AND DNAJC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DNAJC1(22094909)-MLLT10(22002701), # samples:1 MLLT10(22002879)-DNAJC1(22193541), # samples:1
Anticipated loss of major functional domain due to fusion event.	DNAJC1-MLLT10 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. DNAJC1-MLLT10 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. DNAJC1-MLLT10 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. DNAJC1-MLLT10 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MLLT10	GO:0045944	positive regulation of transcription by RNA polymerase II	17868029
Tgene	DNAJC1	GO:0050708	regulation of protein secretion	14668352

Fusion gene breakpoints across MLLT10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DNAJC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	READ	TCGA-AG-A020	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-

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Fusion Gene ORF analysis for MLLT10-DNAJC1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000307729	ENST00000376946	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
5CDS-intron	ENST00000307729	ENST00000483085	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
5CDS-intron	ENST00000377059	ENST00000376946	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
5CDS-intron	ENST00000377059	ENST00000483085	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
5CDS-intron	ENST00000377072	ENST00000376946	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
5CDS-intron	ENST00000377072	ENST00000483085	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
5CDS-intron	ENST00000446906	ENST00000376946	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
5CDS-intron	ENST00000446906	ENST00000483085	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
In-frame	ENST00000307729	ENST00000376980	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
In-frame	ENST00000377059	ENST00000376980	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
In-frame	ENST00000377072	ENST00000376980	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
In-frame	ENST00000446906	ENST00000376980	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
intron-3CDS	ENST00000377091	ENST00000376980	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
intron-3CDS	ENST00000377100	ENST00000376980	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
intron-3CDS	ENST00000495130	ENST00000376980	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
intron-intron	ENST00000377091	ENST00000376946	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
intron-intron	ENST00000377091	ENST00000483085	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
intron-intron	ENST00000377100	ENST00000376946	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
intron-intron	ENST00000377100	ENST00000483085	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
intron-intron	ENST00000495130	ENST00000376946	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-
intron-intron	ENST00000495130	ENST00000483085	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000446906	MLLT10	chr10	22002879	+	ENST00000376980	DNAJC1	chr10	22193541	-	3312	2226	330	3161	943
ENST00000377072	MLLT10	chr10	22002879	+	ENST00000376980	DNAJC1	chr10	22193541	-	3360	2274	330	3209	959
ENST00000307729	MLLT10	chr10	22002879	+	ENST00000376980	DNAJC1	chr10	22193541	-	3142	2056	160	2991	943
ENST00000377059	MLLT10	chr10	22002879	+	ENST00000376980	DNAJC1	chr10	22193541	-	2964	1878	0	2813	937

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000446906	ENST00000376980	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-	0.001535282	0.9984647
ENST00000377072	ENST00000376980	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-	0.001194709	0.9988053
ENST00000307729	ENST00000376980	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-	0.001627448	0.9983726
ENST00000377059	ENST00000376980	MLLT10	chr10	22002879	+	DNAJC1	chr10	22193541	-	0.00165633	0.9983437

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Fusion Genomic Features for MLLT10-DNAJC1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MLLT10-DNAJC1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:22094909/chr10:22002701)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MLLT10 P55197	DNAJC1 Q96DA6
FUNCTION: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269\|PubMed:17868029, ECO:0000269\|PubMed:26439302}.	FUNCTION: Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). {ECO:0000250\|UniProtKB:Q07914, ECO:0000250\|UniProtKB:Q9CQV7}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000307729

229_240

626

1069.0

Compositional bias

Note=Glu/Lys-rich

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377072

229_240

642

1476.0

Compositional bias

Note=Glu/Lys-rich

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000307729

80_287

626

1069.0

Region

Note=Self-association

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377072

80_287

642

1476.0

Region

Note=Self-association

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000307729

135_198

626

1069.0

Zinc finger

PHD-type 2

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000307729

22_74

626

1069.0

Zinc finger

PHD-type 1

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000307729

79_112

626

1069.0

Zinc finger

C2HC pre-PHD-type

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377072

135_198

642

1476.0

Zinc finger

PHD-type 2

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377072

22_74

642

1476.0

Zinc finger

PHD-type 1

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377072

79_112

642

1476.0

Zinc finger

C2HC pre-PHD-type

Tgene

DNAJC1

chr10:22002879

chr10:22193541

ENST00000376980

325_379

243

555.0

Domain

SANT 1

Tgene

DNAJC1

chr10:22002879

chr10:22193541

ENST00000376980

492_547

243

555.0

Domain

SANT 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377091

229_240

127.0

Compositional bias

Note=Glu/Lys-rich

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377100

229_240

180.0

Compositional bias

Note=Glu/Lys-rich

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000307729

311_674

626

1069.0

Region

Note=DNA-binding

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000307729

703_784

626

1069.0

Region

Note=Transactivation domain%3B required for DOT1L-binding

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000307729

750_778

626

1069.0

Region

Note=Leucine-zipper

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377072

311_674

642

1476.0

Region

Note=DNA-binding

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377072

703_784

642

1476.0

Region

Note=Transactivation domain%3B required for DOT1L-binding

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377072

750_778

642

1476.0

Region

Note=Leucine-zipper

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377091

311_674

127.0

Region

Note=DNA-binding

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377091

703_784

127.0

Region

Note=Transactivation domain%3B required for DOT1L-binding

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377091

750_778

127.0

Region

Note=Leucine-zipper

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377091

80_287

127.0

Region

Note=Self-association

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377100

311_674

180.0

Region

Note=DNA-binding

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377100

703_784

180.0

Region

Note=Transactivation domain%3B required for DOT1L-binding

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377100

750_778

180.0

Region

Note=Leucine-zipper

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377100

80_287

180.0

Region

Note=Self-association

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377091

135_198

127.0

Zinc finger

PHD-type 2

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377091

22_74

127.0

Zinc finger

PHD-type 1

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377091

79_112

127.0

Zinc finger

C2HC pre-PHD-type

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377100

135_198

180.0

Zinc finger

PHD-type 2

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377100

22_74

180.0

Zinc finger

PHD-type 1

Hgene

MLLT10

chr10:22002879

chr10:22193541

ENST00000377100

79_112

180.0

Zinc finger

C2HC pre-PHD-type

Tgene

DNAJC1

chr10:22002879

chr10:22193541

ENST00000376980

65_129

243

555.0

Domain

Tgene

DNAJC1

chr10:22002879

chr10:22193541

ENST00000376980

175_554

243

555.0

Topological domain

Cytoplasmic

Tgene

DNAJC1

chr10:22002879

chr10:22193541

ENST00000376980

48_153

243

555.0

Topological domain

Lumenal

Tgene

DNAJC1

chr10:22002879

chr10:22193541

ENST00000376980

154_174

243

555.0

Transmembrane

Helical

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Fusion Gene Sequence for MLLT10-DNAJC1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>54258_54258_1_MLLT10-DNAJC1_MLLT10_chr10_22002879_ENST00000307729_DNAJC1_chr10_22193541_ENST00000376980_length(transcript)=3142nt_BP=2056nt
CTTGATTATGTGTGCCCTCTCCGGGCGCCCGCGTTAGCGGCCGGGTGGAGGTGGGGAGGGAAGACGCTGAGGAGGAGGAGGAGGCGGAGG
AGGCGGTGGAGGGGAGGTGGGGGGAATCAGCAAGGACATGGCTCCTGACTCCTGTGCGGAACGTGAGTGACTGAGCGGCAAAGCCCGAAT
GGTCTCTAGCGACCGGCCCGTGTCACTGGAGGACGAGGTCTCCCATAGTATGAAGGAGATGATTGGAGGCTGTTGCGTTTGCTCAGACGA
GAGAGGCTGGGCCGAGAACCCGCTGGTTTATTGCGACGGGCACGGCTGCAGCGTCGCGGTGCATCAAGCTTGCTATGGCATTGTTCAAGT
ACCCACTGGACCGTGGTTTTGCAGGAAATGTGAATCTCAGGAGAGAGCAGCCAGAGTGAGATGTGAACTTTGTCCCCATAAGGATGGAGC
TTTAAAAAGAACAGATAATGGGGGTTGGGCCCATGTGGTTTGTGCCCTGTATATTCCAGAGGTACAATTTGCCAATGTTTCCACAATGGA
ACCAATTGTTTTACAGTCTGTTCCGCATGATCGTTATAATAAGACTTGCTACATTTGTGATGAACAAGGAAGAGAAAGCAAAGCAGCCAC
TGGTGCTTGCATGACATGTAATAAACATGGATGTCGACAGGCTTTCCATGTAACATGCGCTCAGTTTGCCGGACTGCTTTGTGAAGAAGA
AGGTAATGGTGCCGATAATGTCCAATACTGTGGCTACTGTAAATACCATTTTAGTAAGCTGAAAAAGAGCAAACGGGGATCTAATAGGTC
ATATGATCAAAGTTTAAGTGATTCTTCCTCTCACTCTCAGGATAAACATCATGAGAAAGAGAAAAAAAAATATAAAGAGAAGGACAAACA
CAAACAGAAACACAAGAAGCAGCCAGAACCATCACCTGCATTGGTTCCATCCTTGACTGTTACTACAGAAAAAACTTATACAAGCACTAG
CAACAACTCTATATCTGGATCATTGAAGCGCTTGGAAGATACTACTGCACGATTTACAAATGCAAATTTCCAGGAAGTCTCTGCACACAC
CTCTAGTGGAAAAGATGTTTCAGAGACTAGAGGGTCAGAGGGCAAAGGGAAGAAATCTTCAGCTCACAGCTCAGGTCAAAGGGGAAGAAA
GCCTGGTGGTGGAAGAAATCCAGGAACAACTGTGTCAGCAGCTAGCCCTTTTCCTCAAGGCAGTTTTTCAGGAACTCCAGGCAGTGTAAA
GTCATCTTCTGGAAGTTCAGTGCAGTCTCCCCAGGATTTCCTGAGCTTTACAGACTCAGATCTGCGTAATGACAGTTACTCTCACTCCCA
ACAGTCATCAGCAACCAAAGATGTACATAAAGGAGAGTCTGGAAGCCAGGAAGGGGGGGTAAATAGTTTTAGTACCTTAATTGGCCTCCC
TTCAACCTCAGCTGTTACTTCACAGCCTAAAAGCTTTGAAAATTCACCTGGAGATTTGGGTAATTCCAGCCTTCCTACAGCAGGATATAA
GCGGGCTCAAACTTCTGGCATAGAAGAAGAAACTGTAAAGGAAAAGAAAAGGAAAGGAAATAAACAAAGTAAGCATGGGCCTGGCAGACC
CAAAGGAAACAAAAATCAAGAGAATGTTTCTCATCTCTCAGTTTCTTCTGCTTCACCAACATCATCTGTAGCATCAGCTGCAGGAAGCAT
AACAAGCTCTAGTCTGCAGAAATCTCCTACATTGCTCAGGAATGGAAGTTTACAGAGCCTCAGTGTTGGCTCATCTCCAGTTGGTTCAGA
AATTTCCATGCAGTATCGGCATGATGGAGCTTGCCCAACAACTACGTTCTCAGAGTTGCTGAATGCAATACACAACGGTATTTATAACAG
CAATGATGTAGCAGTATCGTTTCCAAATGTAGTATCTGGCTCGGGATCTAGTACTCCTGTCTCCAGCTCTCACTTACCTCAGCAGTCTTC
TGGGCATTTGCAACAAGTAGGAGCGCTCTCTCCCTCAGCTGTGTCATCTGCAGCCCCTGCTGTTGCTACAACTCAGGATGCTGGGCAGTT
TTATGCTAAATATAAAGAAACAAGATTGAAGGAAAAGGAAGATGCACTGACTAGAACTGAACTTGAAACACTTCAAAAACAGAAGAAAGT
TAAAAAACCAAAACCTGAATTTCCTGTATACACACCTTTAGAAACTACATATATTCAGTCTTATGATCATGGAACTTCCATAGAAGAAAT
TGAGGAACAAATGGATGATTGGTTGGAAAACAGGAACCGAACACAGAAAAAACAGGCACCTGAATGGACAGAAGAGGACCTCAGCCAACT
GACAAGAAGTATGGTTAAGTTCCCAGGAGGGACTCCAGGTCGATGGGAAAAGATTGCCCACGAATTGGGTCGATCTGTGACAGATGTGAC
AACCAAAGCCAAGCAACTGAAGGATTCAGTGACCTGCTCCCCAGGAATGGTTAGACTCTCCGAACTCAAATCGACAGTTCAGAATTCCAG
GCCCATCAAAACGGCCACCACCTTGCCCGATGACATGATCACCCAGCGAGAGGACGCAGAGGGGGTGGCAGCGGAGGAGGAGCAGGAGGG
AGACTCCGGTGAGCAGGAGACCGGGGCCACTGATGCCCGGCCTCGGAGGCGGAAGCCAGCCAGGCTGCTGGAGGCTACAGCGAAGCCGGA
GCCAGAGGAGAAGTCCAGAGCCAAGCGGCAGAAGGACTTTGACATAGCAGAACAAAACGAGTCCAGCGACGAGGAGAGCCTGAGAAAAGA
GAGAGCTCGGTCTGCAGAGGAGCCGTGGACTCAAAATCAACAGAAACTTCTGGAACTGGCGTTGCAGCAGTACCCAAGGGGATCCTCTGA
CCGCTGGGACAAAATAGCCAGATGTGTCCCGTCCAAGAGCAAGGAAGACTGTATCGCTAGGTACAAGTTGCTGGTTGAACTGGTCCAAAA
GAAAAAACAAGCTAAAAGCTGAATATTCTGGGAGATGATGTTCACCTTCATTTTCCAAAATGAATATCTTAAAAATCTTATGCAGAAATT

>54258_54258_1_MLLT10-DNAJC1_MLLT10_chr10_22002879_ENST00000307729_DNAJC1_chr10_22193541_ENST00000376980_length(amino acids)=943AA_BP=632
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCEL
CPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFA
GLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTE
KTYTSTSNNSISGSLKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFS
GTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSS
LPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVG
SSPVGSEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVAT
TQDAGQFYAKYKETRLKEKEDALTRTELETLQKQKKVKKPKPEFPVYTPLETTYIQSYDHGTSIEEIEEQMDDWLENRNRTQKKQAPEWT
EEDLSQLTRSMVKFPGGTPGRWEKIAHELGRSVTDVTTKAKQLKDSVTCSPGMVRLSELKSTVQNSRPIKTATTLPDDMITQREDAEGVA
AEEEQEGDSGEQETGATDARPRRRKPARLLEATAKPEPEEKSRAKRQKDFDIAEQNESSDEESLRKERARSAEEPWTQNQQKLLELALQQ

--------------------------------------------------------------
>54258_54258_2_MLLT10-DNAJC1_MLLT10_chr10_22002879_ENST00000377059_DNAJC1_chr10_22193541_ENST00000376980_length(transcript)=2964nt_BP=1878nt
ATGGTCTCTAGCGACCGGCCCGTGTCACTGGAGGACGAGGTCTCCCATAGTATGAAGGAGATGATTGGAGGCTGTTGCGTTTGCTCAGAC
GAGAGAGGCTGGGCCGAGAACCCGCTGGTTTATTGCGACGGGCACGGCTGCAGCGTCGCGGTGCATCAAGCTTGCTATGGCATTGTTCAA
GTACCCACTGGACCGTGGTTTTGCAGGAAATGTGAATCTCAGGAGAGAGCAGCCAGAGTGAGATGTGAACTTTGTCCCCATAAGGATGGA
GCTTTAAAAAGAACAGATAATGGGGGTTGGGCCCATGTGGTTTGTGCCCTGTATATTCCAGAGGTACAATTTGCCAATGTTTCCACAATG
GAACCAATTGTTTTACAGTCTGTTCCGCATGATCGTTATAATAAGACTTGCTACATTTGTGATGAACAAGGAAGAGAAAGCAAAGCAGCC
ACTGGTGCTTGCATGACATGTAATAAACATGGATGTCGACAGGCTTTCCATGTAACATGCGCTCAGTTTGCCGGACTGCTTTGTGAAGAA
GAAGGTAATGGTGCCGATAATGTCCAATACTGTGGCTACTGTAAATACCATTTTAGTAAGCTGAAAAAGAGCAAACGGGGATCTAATAGG
TCATATGATCAAAGTTTAAGTGATTCTTCCTCTCACTCTCAGGATAAACATCATGAGAAAGAGAAAAAAAAATATAAAGAGAAGGACAAA
CACAAACAGAAACACAAGAAGCAGCCAGAACCATCACCTGCATTGGTTCCATCCTTGACTGTTACTACAGAAAAAACTTATACAAGCACT
AGCAACAACTCTATATCTGGATCATTGAAGCGCTTGGAAGATACTACTGCACGATTTACAAATGCAAATTTCCAGGAAGTCTCTGCACAC
ACCTCTAGTGGAAAAGATGTTTCAGAGACTAGAGGGTCAGAGGGCAAAGGGAAGAAATCTTCAGCTCACAGCTCAGGTCAAAGGGGAAGA
AAGCCTGGTGGTGGAAGAAATCCAGGAACAACTGTGTCAGCAGCTAGCCCTTTTCCTCAAGGCAGTTTTTCAGGAACTCCAGGCAGTGTA
AAGTCATCTTCTGGAAGTTCAGTGCAGTCTCCCCAGGATTTCCTGAGCTTTACAGACTCAGATCTGCGTAATGACAGTTACTCTCACTCC
CAACAGTCATCAGCAACCAAAGATGTACATAAAGGAGAGTCTGGAAGCCAGGAAGGGGGGGTAAATAGTTTTAGTACCTTAATTGGCCTC
CCTTCAACCTCAGCTGTTACTTCACAGCCTAAAAGCTTTGAAAATTCACCTGGAGATTTGGGTAATTCCAGCCTTCCTACAGCAGGATAT
AAGCGGGCTCAAACTTCTGGCATAGAAGAAGAAACTGTAAAGGAAAAGAAAAGGAAAGGAAATAAACAAAGTAAGCATGGGCCTGGCAGA
CCCAAAGGAAACAAAAATCAAGAGAATGTTTCTCATCTCTCAGTTTCTTCTGCTTCACCAACATCATCTGTAGCATCAGCTGCAGGAAGC
ATAACAAGCTCTAGTCTGCAGAAATCTCCTACATTGCTCAGGAATGGAAGTTTACAGAGCCTCAGTGTTGGCTCATCTCCAGTTGGTTCA
GAAATTTCCATGCAGTATCGGCATGATGGAGCTTGCCCAACAACTACGTTCTCAGAGTTGCTGAATGCAATACACAACGGTATTTATAAC
AGCAATGATGTAGCAGTATCGTTTCCAAATGTAGTATCTGGCTCGGGATCTAGTACTCCTGTCTCCAGCTCTCACTTACCTCAGCAGTCT
TCTGGGCATTTGCAACAAGTAGGAGCGCTCTCTCCCTCAGCTGTGTCATCTGCAGCCCCTGCTGTTGCTACAACTCAGGATGCTGGGCAG
TTTTATGCTAAATATAAAGAAACAAGATTGAAGGAAAAGGAAGATGCACTGACTAGAACTGAACTTGAAACACTTCAAAAACAGAAGAAA
GTTAAAAAACCAAAACCTGAATTTCCTGTATACACACCTTTAGAAACTACATATATTCAGTCTTATGATCATGGAACTTCCATAGAAGAA
ATTGAGGAACAAATGGATGATTGGTTGGAAAACAGGAACCGAACACAGAAAAAACAGGCACCTGAATGGACAGAAGAGGACCTCAGCCAA
CTGACAAGAAGTATGGTTAAGTTCCCAGGAGGGACTCCAGGTCGATGGGAAAAGATTGCCCACGAATTGGGTCGATCTGTGACAGATGTG
ACAACCAAAGCCAAGCAACTGAAGGATTCAGTGACCTGCTCCCCAGGAATGGTTAGACTCTCCGAACTCAAATCGACAGTTCAGAATTCC
AGGCCCATCAAAACGGCCACCACCTTGCCCGATGACATGATCACCCAGCGAGAGGACGCAGAGGGGGTGGCAGCGGAGGAGGAGCAGGAG
GGAGACTCCGGTGAGCAGGAGACCGGGGCCACTGATGCCCGGCCTCGGAGGCGGAAGCCAGCCAGGCTGCTGGAGGCTACAGCGAAGCCG
GAGCCAGAGGAGAAGTCCAGAGCCAAGCGGCAGAAGGACTTTGACATAGCAGAACAAAACGAGTCCAGCGACGAGGAGAGCCTGAGAAAA
GAGAGAGCTCGGTCTGCAGAGGAGCCGTGGACTCAAAATCAACAGAAACTTCTGGAACTGGCGTTGCAGCAGTACCCAAGGGGATCCTCT
GACCGCTGGGACAAAATAGCCAGATGTGTCCCGTCCAAGAGCAAGGAAGACTGTATCGCTAGGTACAAGTTGCTGGTTGAACTGGTCCAA
AAGAAAAAACAAGCTAAAAGCTGAATATTCTGGGAGATGATGTTCACCTTCATTTTCCAAAATGAATATCTTAAAAATCTTATGCAGAAA

>54258_54258_2_MLLT10-DNAJC1_MLLT10_chr10_22002879_ENST00000377059_DNAJC1_chr10_22193541_ENST00000376980_length(amino acids)=937AA_BP=626
MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDG
ALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEE
EGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTST
SNNSISGSLKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSV
KSSSGSSVQSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAGY
KRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVGS
EISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQDAGQ
FYAKYKETRLKEKEDALTRTELETLQKQKKVKKPKPEFPVYTPLETTYIQSYDHGTSIEEIEEQMDDWLENRNRTQKKQAPEWTEEDLSQ
LTRSMVKFPGGTPGRWEKIAHELGRSVTDVTTKAKQLKDSVTCSPGMVRLSELKSTVQNSRPIKTATTLPDDMITQREDAEGVAAEEEQE
GDSGEQETGATDARPRRRKPARLLEATAKPEPEEKSRAKRQKDFDIAEQNESSDEESLRKERARSAEEPWTQNQQKLLELALQQYPRGSS

--------------------------------------------------------------
>54258_54258_3_MLLT10-DNAJC1_MLLT10_chr10_22002879_ENST00000377072_DNAJC1_chr10_22193541_ENST00000376980_length(transcript)=3360nt_BP=2274nt
CGCGCACGCAGGGCTAGCCTCGCCCAGGCCTCCTCCCTCACGCCGGCCGCAGGACGGGCGCGCACGCCAAGTGACGCTCCGAGGAGGAAG
CGCAGCCCCCTTCCCCTCCCTCGCTGCCCCTGGCCCAGCGGGAGCCCCCCCTCCCCCCAGTGCGCCTGTGCGGAGGCCCTCTTGATTATG
TGTGCCCTCTCCGGGCGCCCGCGTTAGCGGCCGGGTGGAGGTGGGGAGGGAAGACGCTGAGGAGGAGGAGGAGGCGGAGGAGGCGGTGGA
GGGGAGGTGGGGGGAATCAGCAAGGACATGGCTCCTGACTCCTGTGCGGAACGTGAGTGACTGAGCGGCAAAGCCCGAATGGTCTCTAGC
GACCGGCCCGTGTCACTGGAGGACGAGGTCTCCCATAGTATGAAGGAGATGATTGGAGGCTGTTGCGTTTGCTCAGACGAGAGAGGCTGG
GCCGAGAACCCGCTGGTTTATTGCGACGGGCACGGCTGCAGCGTCGCGGTGCATCAAGCTTGCTATGGCATTGTTCAAGTACCCACTGGA
CCGTGGTTTTGCAGGAAATGTGAATCTCAGGAGAGAGCAGCCAGAGTGAGATGTGAACTTTGTCCCCATAAGGATGGAGCTTTAAAAAGA
ACAGATAATGGGGGTTGGGCCCATGTGGTTTGTGCCCTGTATATTCCAGAGGTACAATTTGCCAATGTTTCCACAATGGAACCAATTGTT
TTACAGTCTGTTCCGCATGATCGTTATAATAAGACTTGCTACATTTGTGATGAACAAGGAAGAGAAAGCAAAGCAGCCACTGGTGCTTGC
ATGACATGTAATAAACATGGATGTCGACAGGCTTTCCATGTAACATGCGCTCAGTTTGCCGGACTGCTTTGTGAAGAAGAAGGTAATGGT
GCCGATAATGTCCAATACTGTGGCTACTGTAAATACCATTTTAGTAAGCTGAAAAAGAGCAAACGGGGATCTAATAGGTCATATGATCAA
AGTTTAAGTGATTCTTCCTCTCACTCTCAGGATAAACATCATGAGAAAGAGAAAAAAAAATATAAAGAGAAGGACAAACACAAACAGAAA
CACAAGAAGCAGCCAGAACCATCACCTGCATTGGTTCCATCCTTGACTGTTACTACAGAAAAAACTTATACAAGCACTAGCAACAACTCT
ATATCTGGATCATTGAAGCGCTTGGAAGATACTACTGCACGATTTACAAATGCAAATTTCCAGGAAGTCTCTGCACACACCTCTAGTGGA
AAAGATGTTTCAGAGACTAGAGGGTCAGAGGGCAAAGGGAAGAAATCTTCAGCTCACAGCTCAGGTCAAAGGGGAAGAAAGCCTGGTGGT
GGAAGAAATCCAGGAACAACTGTGTCAGCAGCTAGCCCTTTTCCTCAAGGCAGTTTTTCAGGAACTCCAGGCAGTGTAAAGTCATCTTCT
GGAAGTTCAGTGCAGTCTCCCCAGGATTTCCTGAGCTTTACAGACTCAGATCTGCGTAATGACAGTTACTCTCACTCCCAACAGTCATCA
GCAACCAAAGATGTACATAAAGGAGAGTCTGGAAGCCAGGAAGGGGGGGTAAATAGTTTTAGTACCTTAATTGGCCTCCCTTCAACCTCA
GCTGTTACTTCACAGCCTAAAAGCTTTGAAAATTCACCTGGAGATTTGGGTAATTCCAGCCTTCCTACAGCAGGATATAAGCGGGCTCAA
ACTTCTGGCATAGAAGAAGAAACTGTAAAGGAAAAGAAAAGGAAAGGAAATAAACAAAGTAAGCATGGGCCTGGCAGACCCAAAGGAAAC
AAAAATCAAGAGAATGTTTCTCATCTCTCAGTTTCTTCTGCTTCACCAACATCATCTGTAGCATCAGCTGCAGGAAGCATAACAAGCTCT
AGTCTGCAGAAATCTCCTACATTGCTCAGGAATGGAAGTTTACAGAGCCTCAGTGTTGGCTCATCTCCAGTTGGTTCAGAAATTTCCATG
CAGTATCGGCATGATGGAGCTTGCCCAACAACTACGTTCTCAGAGTTGCTGAATGCAATACACAACGACAGAGGTGACAGTTCTACACTA
ACAAAGCAAGAACTTAAATTCATAGGTATTTATAACAGCAATGATGTAGCAGTATCGTTTCCAAATGTAGTATCTGGCTCGGGATCTAGT
ACTCCTGTCTCCAGCTCTCACTTACCTCAGCAGTCTTCTGGGCATTTGCAACAAGTAGGAGCGCTCTCTCCCTCAGCTGTGTCATCTGCA
GCCCCTGCTGTTGCTACAACTCAGGATGCTGGGCAGTTTTATGCTAAATATAAAGAAACAAGATTGAAGGAAAAGGAAGATGCACTGACT
AGAACTGAACTTGAAACACTTCAAAAACAGAAGAAAGTTAAAAAACCAAAACCTGAATTTCCTGTATACACACCTTTAGAAACTACATAT
ATTCAGTCTTATGATCATGGAACTTCCATAGAAGAAATTGAGGAACAAATGGATGATTGGTTGGAAAACAGGAACCGAACACAGAAAAAA
CAGGCACCTGAATGGACAGAAGAGGACCTCAGCCAACTGACAAGAAGTATGGTTAAGTTCCCAGGAGGGACTCCAGGTCGATGGGAAAAG
ATTGCCCACGAATTGGGTCGATCTGTGACAGATGTGACAACCAAAGCCAAGCAACTGAAGGATTCAGTGACCTGCTCCCCAGGAATGGTT
AGACTCTCCGAACTCAAATCGACAGTTCAGAATTCCAGGCCCATCAAAACGGCCACCACCTTGCCCGATGACATGATCACCCAGCGAGAG
GACGCAGAGGGGGTGGCAGCGGAGGAGGAGCAGGAGGGAGACTCCGGTGAGCAGGAGACCGGGGCCACTGATGCCCGGCCTCGGAGGCGG
AAGCCAGCCAGGCTGCTGGAGGCTACAGCGAAGCCGGAGCCAGAGGAGAAGTCCAGAGCCAAGCGGCAGAAGGACTTTGACATAGCAGAA
CAAAACGAGTCCAGCGACGAGGAGAGCCTGAGAAAAGAGAGAGCTCGGTCTGCAGAGGAGCCGTGGACTCAAAATCAACAGAAACTTCTG
GAACTGGCGTTGCAGCAGTACCCAAGGGGATCCTCTGACCGCTGGGACAAAATAGCCAGATGTGTCCCGTCCAAGAGCAAGGAAGACTGT
ATCGCTAGGTACAAGTTGCTGGTTGAACTGGTCCAAAAGAAAAAACAAGCTAAAAGCTGAATATTCTGGGAGATGATGTTCACCTTCATT
TTCCAAAATGAATATCTTAAAAATCTTATGCAGAAATTTGCATTTTGTACCTCAATATTTCTACGTCATGTGCCTTAGTAAAAAAAAATA

>54258_54258_3_MLLT10-DNAJC1_MLLT10_chr10_22002879_ENST00000377072_DNAJC1_chr10_22193541_ENST00000376980_length(amino acids)=959AA_BP=648
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCEL
CPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFA
GLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTE
KTYTSTSNNSISGSLKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFS
GTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSS
LPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVG
SSPVGSEISMQYRHDGACPTTTFSELLNAIHNDRGDSSTLTKQELKFIGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVG
ALSPSAVSSAAPAVATTQDAGQFYAKYKETRLKEKEDALTRTELETLQKQKKVKKPKPEFPVYTPLETTYIQSYDHGTSIEEIEEQMDDW
LENRNRTQKKQAPEWTEEDLSQLTRSMVKFPGGTPGRWEKIAHELGRSVTDVTTKAKQLKDSVTCSPGMVRLSELKSTVQNSRPIKTATT
LPDDMITQREDAEGVAAEEEQEGDSGEQETGATDARPRRRKPARLLEATAKPEPEEKSRAKRQKDFDIAEQNESSDEESLRKERARSAEE

--------------------------------------------------------------
>54258_54258_4_MLLT10-DNAJC1_MLLT10_chr10_22002879_ENST00000446906_DNAJC1_chr10_22193541_ENST00000376980_length(transcript)=3312nt_BP=2226nt
CGCGCACGCAGGGCTAGCCTCGCCCAGGCCTCCTCCCTCACGCCGGCCGCAGGACGGGCGCGCACGCCAAGTGACGCTCCGAGGAGGAAG
CGCAGCCCCCTTCCCCTCCCTCGCTGCCCCTGGCCCAGCGGGAGCCCCCCCTCCCCCCAGTGCGCCTGTGCGGAGGCCCTCTTGATTATG
TGTGCCCTCTCCGGGCGCCCGCGTTAGCGGCCGGGTGGAGGTGGGGAGGGAAGACGCTGAGGAGGAGGAGGAGGCGGAGGAGGCGGTGGA
GGGGAGGTGGGGGGAATCAGCAAGGACATGGCTCCTGACTCCTGTGCGGAACGTGAGTGACTGAGCGGCAAAGCCCGAATGGTCTCTAGC
GACCGGCCCGTGTCACTGGAGGACGAGGTCTCCCATAGTATGAAGGAGATGATTGGAGGCTGTTGCGTTTGCTCAGACGAGAGAGGCTGG
GCCGAGAACCCGCTGGTTTATTGCGACGGGCACGGCTGCAGCGTCGCGGTGCATCAAGCTTGCTATGGCATTGTTCAAGTACCCACTGGA
CCGTGGTTTTGCAGGAAATGTGAATCTCAGGAGAGAGCAGCCAGAGTGAGATGTGAACTTTGTCCCCATAAGGATGGAGCTTTAAAAAGA
ACAGATAATGGGGGTTGGGCCCATGTGGTTTGTGCCCTGTATATTCCAGAGGTACAATTTGCCAATGTTTCCACAATGGAACCAATTGTT
TTACAGTCTGTTCCGCATGATCGTTATAATAAGACTTGCTACATTTGTGATGAACAAGGAAGAGAAAGCAAAGCAGCCACTGGTGCTTGC
ATGACATGTAATAAACATGGATGTCGACAGGCTTTCCATGTAACATGCGCTCAGTTTGCCGGACTGCTTTGTGAAGAAGAAGGTAATGGT
GCCGATAATGTCCAATACTGTGGCTACTGTAAATACCATTTTAGTAAGCTGAAAAAGAGCAAACGGGGATCTAATAGGTCATATGATCAA
AGTTTAAGTGATTCTTCCTCTCACTCTCAGGATAAACATCATGAGAAAGAGAAAAAAAAATATAAAGAGAAGGACAAACACAAACAGAAA
CACAAGAAGCAGCCAGAACCATCACCTGCATTGGTTCCATCCTTGACTGTTACTACAGAAAAAACTTATACAAGCACTAGCAACAACTCT
ATATCTGGATCATTGAAGCGCTTGGAAGATACTACTGCACGATTTACAAATGCAAATTTCCAGGAAGTCTCTGCACACACCTCTAGTGGA
AAAGATGTTTCAGAGACTAGAGGGTCAGAGGGCAAAGGGAAGAAATCTTCAGCTCACAGCTCAGGTCAAAGGGGAAGAAAGCCTGGTGGT
GGAAGAAATCCAGGAACAACTGTGTCAGCAGCTAGCCCTTTTCCTCAAGGCAGTTTTTCAGGAACTCCAGGCAGTGTAAAGTCATCTTCT
GGAAGTTCAGTGCAGTCTCCCCAGGATTTCCTGAGCTTTACAGACTCAGATCTGCGTAATGACAGTTACTCTCACTCCCAACAGTCATCA
GCAACCAAAGATGTACATAAAGGAGAGTCTGGAAGCCAGGAAGGGGGGGTAAATAGTTTTAGTACCTTAATTGGCCTCCCTTCAACCTCA
GCTGTTACTTCACAGCCTAAAAGCTTTGAAAATTCACCTGGAGATTTGGGTAATTCCAGCCTTCCTACAGCAGGATATAAGCGGGCTCAA
ACTTCTGGCATAGAAGAAGAAACTGTAAAGGAAAAGAAAAGGAAAGGAAATAAACAAAGTAAGCATGGGCCTGGCAGACCCAAAGGAAAC
AAAAATCAAGAGAATGTTTCTCATCTCTCAGTTTCTTCTGCTTCACCAACATCATCTGTAGCATCAGCTGCAGGAAGCATAACAAGCTCT
AGTCTGCAGAAATCTCCTACATTGCTCAGGAATGGAAGTTTACAGAGCCTCAGTGTTGGCTCATCTCCAGTTGGTTCAGAAATTTCCATG
CAGTATCGGCATGATGGAGCTTGCCCAACAACTACGTTCTCAGAGTTGCTGAATGCAATACACAACGGTATTTATAACAGCAATGATGTA
GCAGTATCGTTTCCAAATGTAGTATCTGGCTCGGGATCTAGTACTCCTGTCTCCAGCTCTCACTTACCTCAGCAGTCTTCTGGGCATTTG
CAACAAGTAGGAGCGCTCTCTCCCTCAGCTGTGTCATCTGCAGCCCCTGCTGTTGCTACAACTCAGGATGCTGGGCAGTTTTATGCTAAA
TATAAAGAAACAAGATTGAAGGAAAAGGAAGATGCACTGACTAGAACTGAACTTGAAACACTTCAAAAACAGAAGAAAGTTAAAAAACCA
AAACCTGAATTTCCTGTATACACACCTTTAGAAACTACATATATTCAGTCTTATGATCATGGAACTTCCATAGAAGAAATTGAGGAACAA
ATGGATGATTGGTTGGAAAACAGGAACCGAACACAGAAAAAACAGGCACCTGAATGGACAGAAGAGGACCTCAGCCAACTGACAAGAAGT
ATGGTTAAGTTCCCAGGAGGGACTCCAGGTCGATGGGAAAAGATTGCCCACGAATTGGGTCGATCTGTGACAGATGTGACAACCAAAGCC
AAGCAACTGAAGGATTCAGTGACCTGCTCCCCAGGAATGGTTAGACTCTCCGAACTCAAATCGACAGTTCAGAATTCCAGGCCCATCAAA
ACGGCCACCACCTTGCCCGATGACATGATCACCCAGCGAGAGGACGCAGAGGGGGTGGCAGCGGAGGAGGAGCAGGAGGGAGACTCCGGT
GAGCAGGAGACCGGGGCCACTGATGCCCGGCCTCGGAGGCGGAAGCCAGCCAGGCTGCTGGAGGCTACAGCGAAGCCGGAGCCAGAGGAG
AAGTCCAGAGCCAAGCGGCAGAAGGACTTTGACATAGCAGAACAAAACGAGTCCAGCGACGAGGAGAGCCTGAGAAAAGAGAGAGCTCGG
TCTGCAGAGGAGCCGTGGACTCAAAATCAACAGAAACTTCTGGAACTGGCGTTGCAGCAGTACCCAAGGGGATCCTCTGACCGCTGGGAC
AAAATAGCCAGATGTGTCCCGTCCAAGAGCAAGGAAGACTGTATCGCTAGGTACAAGTTGCTGGTTGAACTGGTCCAAAAGAAAAAACAA
GCTAAAAGCTGAATATTCTGGGAGATGATGTTCACCTTCATTTTCCAAAATGAATATCTTAAAAATCTTATGCAGAAATTTGCATTTTGT

>54258_54258_4_MLLT10-DNAJC1_MLLT10_chr10_22002879_ENST00000446906_DNAJC1_chr10_22193541_ENST00000376980_length(amino acids)=943AA_BP=632
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCEL
CPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFA
GLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTE
KTYTSTSNNSISGSLKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFS
GTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSS
LPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVG
SSPVGSEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVAT
TQDAGQFYAKYKETRLKEKEDALTRTELETLQKQKKVKKPKPEFPVYTPLETTYIQSYDHGTSIEEIEEQMDDWLENRNRTQKKQAPEWT
EEDLSQLTRSMVKFPGGTPGRWEKIAHELGRSVTDVTTKAKQLKDSVTCSPGMVRLSELKSTVQNSRPIKTATTLPDDMITQREDAEGVA
AEEEQEGDSGEQETGATDARPRRRKPARLLEATAKPEPEEKSRAKRQKDFDIAEQNESSDEESLRKERARSAEEPWTQNQQKLLELALQQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MLLT10-DNAJC1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	MLLT10	chr10:22002879	chr10:22193541	ENST00000307729	+	14	23	141_233	626.0	1069.0	FSTL3
Hgene	MLLT10	chr10:22002879	chr10:22193541	ENST00000377072	+	15	24	141_233	642.0	1476.0	FSTL3

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	MLLT10	chr10:22002879	chr10:22193541	ENST00000377091	+	1	5	141_233	0	127.0	FSTL3
Hgene	MLLT10	chr10:22002879	chr10:22193541	ENST00000377100	+	1	4	141_233	0	180.0	FSTL3

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MLLT10-DNAJC1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MLLT10-DNAJC1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source