FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MLLT10-MINPP1 (FusionGDB2 ID:54264)

Fusion Gene Summary for MLLT10-MINPP1

check button Fusion gene summary
Fusion gene informationFusion gene name: MLLT10-MINPP1
Fusion gene ID: 54264
HgeneTgene
Gene symbol

MLLT10

MINPP1

Gene ID

8028

9562

Gene nameMLLT10 histone lysine methyltransferase DOT1L cofactormultiple inositol-polyphosphate phosphatase 1
SynonymsAF10HIPER1|MINPP2|MIPP
Cytomap

10p12.31

10q23.2

Type of geneprotein-codingprotein-coding
Descriptionprotein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 protmultiple inositol polyphosphate phosphatase 12,3-BPG phosphatase2,3-bisphosphoglycerate 3-phosphataseinositol (1,3,4,5)-tetrakisphosphate 3-phosphataseins(1,3,4,5)P(4) 3-phosphatasemultiple inositol polyphosphate histidine phosphatase, 1multiple ino
Modification date2020031320200313
UniProtAcc

P55197

Q9UNW1

Ensembl transtripts involved in fusion geneENST00000495130, ENST00000307729, 
ENST00000377059, ENST00000377072, 
ENST00000377091, ENST00000377100, 
ENST00000446906, 		ENST00000371994, 
ENST00000371996, ENST00000536010, 
ENST00000472891, 
Fusion gene scores* DoF score18 X 15 X 10=27007 X 5 X 8=280
# samples 248
** MAII scorelog2(24/2700*10)=-3.49185309632968
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MLLT10 [Title/Abstract] AND MINPP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMLLT10(21823733)-MINPP1(89311839), # samples:3
Anticipated loss of major functional domain due to fusion event.MLLT10-MINPP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MLLT10-MINPP1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
MLLT10-MINPP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MLLT10-MINPP1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMLLT10

GO:0045944

positive regulation of transcription by RNA polymerase II

17868029


check buttonFusion gene breakpoints across MLLT10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MINPP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-BD-A2L6-01AMLLT10chr10

21823733

-MINPP1chr10

89311839

+
ChimerDB4LIHCTCGA-BD-A2L6-01AMLLT10chr10

21823733

+MINPP1chr10

89311839

+


Top

Fusion Gene ORF analysis for MLLT10-MINPP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000495130ENST00000371994MLLT10chr10

21823733

+MINPP1chr10

89311839

+
3UTR-3CDSENST00000495130ENST00000371996MLLT10chr10

21823733

+MINPP1chr10

89311839

+
3UTR-3CDSENST00000495130ENST00000536010MLLT10chr10

21823733

+MINPP1chr10

89311839

+
3UTR-3UTRENST00000495130ENST00000472891MLLT10chr10

21823733

+MINPP1chr10

89311839

+
5CDS-3UTRENST00000307729ENST00000472891MLLT10chr10

21823733

+MINPP1chr10

89311839

+
5CDS-3UTRENST00000377059ENST00000472891MLLT10chr10

21823733

+MINPP1chr10

89311839

+
5CDS-3UTRENST00000377072ENST00000472891MLLT10chr10

21823733

+MINPP1chr10

89311839

+
5CDS-3UTRENST00000377091ENST00000472891MLLT10chr10

21823733

+MINPP1chr10

89311839

+
5CDS-3UTRENST00000377100ENST00000472891MLLT10chr10

21823733

+MINPP1chr10

89311839

+
5CDS-3UTRENST00000446906ENST00000472891MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000307729ENST00000371994MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000307729ENST00000371996MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000307729ENST00000536010MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000377059ENST00000371994MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000377059ENST00000371996MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000377059ENST00000536010MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000377072ENST00000371994MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000377072ENST00000371996MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000377072ENST00000536010MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000377091ENST00000371994MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000377091ENST00000371996MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000377091ENST00000536010MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000377100ENST00000371994MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000377100ENST00000371996MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000377100ENST00000536010MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000446906ENST00000371994MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000446906ENST00000371996MLLT10chr10

21823733

+MINPP1chr10

89311839

+
Frame-shiftENST00000446906ENST00000536010MLLT10chr10

21823733

+MINPP1chr10

89311839

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for MLLT10-MINPP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for MLLT10-MINPP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:21823733/:89311839)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MLLT10

P55197

MINPP1

Q9UNW1

FUNCTION: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}.FUNCTION: Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity). {ECO:0000250|UniProtKB:F1NPQ2, ECO:0000269|PubMed:18413611}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for MLLT10-MINPP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for MLLT10-MINPP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MLLT10-MINPP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MLLT10-MINPP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource