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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MLLT3-SLC28A3 (FusionGDB2 ID:54299)

Fusion Gene Summary for MLLT3-SLC28A3

Fusion gene summary

Fusion gene information	Fusion gene name: MLLT3-SLC28A3
	Fusion gene ID: 54299
		Hgene	Tgene
	Gene symbol	MLLT3	SLC28A3
	Gene ID	4300	64078
	Gene name	MLLT3 super elongation complex subunit	solute carrier family 28 member 3
	Synonyms	AF9\|YEATS3	CNT3
	Cytomap	9p21.3	9q21.32-q21.33
	Type of gene	protein-coding	protein-coding
	Description	protein AF-9ALL1-fused gene from chromosome 9 proteinKMT2A/MLLT3 fusionKMT2A/MLLT3 fusion proteinYEATS domain-containing protein 3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3myeloid/lymphoid or mixed-lineage leu	solute carrier family 28 member 3concentrative Na(+)-nucleoside cotransporter 3concentrative Na+-nucleoside cotransportersolute carrier family 28 (concentrative nucleoside transporter), member 3solute carrier family 28 (sodium-coupled nucleoside trans
	Modification date	20200327	20200313
	UniProtAcc	P42568	.
	Ensembl transtripts involved in fusion gene	ENST00000380338, ENST00000429426, ENST00000355930, ENST00000380321, ENST00000475957,	ENST00000495823, ENST00000537648, ENST00000376238,
Fusion gene scores	* DoF score	18 X 14 X 11=2772	8 X 6 X 4=192
	# samples	25	8
	** MAII score	log2(25/2772*10)=-3.47092725747513 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MLLT3 [Title/Abstract] AND SLC28A3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MLLT3(20456702)-SLC28A3(86928369), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MLLT3	GO:0045893	positive regulation of transcription, DNA-templated	25417107\|27105114
Hgene	MLLT3	GO:0090090	negative regulation of canonical Wnt signaling pathway	19591803

Fusion gene breakpoints across MLLT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SLC28A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A0CU-01A	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-

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Fusion Gene ORF analysis for MLLT3-SLC28A3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000380338	ENST00000495823	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-
5CDS-5UTR	ENST00000380338	ENST00000537648	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-
5CDS-5UTR	ENST00000429426	ENST00000495823	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-
5CDS-5UTR	ENST00000429426	ENST00000537648	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-
5UTR-3CDS	ENST00000355930	ENST00000376238	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-
5UTR-5UTR	ENST00000355930	ENST00000495823	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-
5UTR-5UTR	ENST00000355930	ENST00000537648	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-
In-frame	ENST00000380338	ENST00000376238	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-
In-frame	ENST00000429426	ENST00000376238	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-
intron-3CDS	ENST00000380321	ENST00000376238	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-
intron-3CDS	ENST00000475957	ENST00000376238	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-
intron-5UTR	ENST00000380321	ENST00000495823	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-
intron-5UTR	ENST00000380321	ENST00000537648	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-
intron-5UTR	ENST00000475957	ENST00000495823	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-
intron-5UTR	ENST00000475957	ENST00000537648	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000380338	MLLT3	chr9	20456702	-	ENST00000376238	SLC28A3	chr9	86928369	-	5340	563	287	2578	763
ENST00000429426	MLLT3	chr9	20456702	-	ENST00000376238	SLC28A3	chr9	86928369	-	5142	365	98	2380	760

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000380338	ENST00000376238	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-	0.000446549	0.9995534
ENST00000429426	ENST00000376238	MLLT3	chr9	20456702	-	SLC28A3	chr9	86928369	-	0.000155658	0.9998443

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Fusion Genomic Features for MLLT3-SLC28A3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MLLT3-SLC28A3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:20456702/chr9:86928369)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MLLT3 P42568	.
FUNCTION: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114, PubMed:30385749). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (PubMed:25417107). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than confering, HSC stemness (PubMed:31776511). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PubMed:31776511). {ECO:0000269\|PubMed:20159561, ECO:0000269\|PubMed:20471948, ECO:0000269\|PubMed:25417107, ECO:0000269\|PubMed:27105114, ECO:0000269\|PubMed:27545619, ECO:0000269\|PubMed:30374167, ECO:0000269\|PubMed:30385749, ECO:0000269\|PubMed:31776511}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MLLT3

chr9:20456702

chr9:86928369

ENST00000380338

56_58

569.0

Region

Inhibitor XL-07i binding

Hgene

MLLT3

chr9:20456702

chr9:86928369

ENST00000380338

78_80

569.0

Region

Histone H3K9cr binding

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

124_127

692.0

Topological domain

Extracellular

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

149_170

692.0

Topological domain

Cytoplasmic

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

192_200

692.0

Topological domain

Extracellular

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

222_223

692.0

Topological domain

Cytoplasmic

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

245_287

692.0

Topological domain

Extracellular

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

309_314

692.0

Topological domain

Cytoplasmic

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

336_361

692.0

Topological domain

Extracellular

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

383_388

692.0

Topological domain

Cytoplasmic

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

410_443

692.0

Topological domain

Extracellular

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

465_479

692.0

Topological domain

Cytoplasmic

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

501_553

692.0

Topological domain

Extracellular

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

575_593

692.0

Topological domain

Cytoplasmic

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

615_691

692.0

Topological domain

Extracellular

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

103_123

692.0

Transmembrane

Helical

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

128_148

692.0

Transmembrane

Helical

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

171_191

692.0

Transmembrane

Helical

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

201_221

692.0

Transmembrane

Helical

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

224_244

692.0

Transmembrane

Helical

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

288_308

692.0

Transmembrane

Helical

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

315_335

692.0

Transmembrane

Helical

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

362_382

692.0

Transmembrane

Helical

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

389_409

692.0

Transmembrane

Helical

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

444_464

692.0

Transmembrane

Helical

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

480_500

692.0

Transmembrane

Helical

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

554_574

692.0

Transmembrane

Helical

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

594_614

692.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MLLT3

chr9:20456702

chr9:86928369

ENST00000380338

149_194

569.0

Compositional bias

Note=Poly-Ser

Hgene

MLLT3

chr9:20456702

chr9:86928369

ENST00000380338

383_391

569.0

Compositional bias

Note=Poly-Ser

Hgene

MLLT3

chr9:20456702

chr9:86928369

ENST00000380338

466_469

569.0

Compositional bias

Note=Poly-Pro

Hgene

MLLT3

chr9:20456702

chr9:86928369

ENST00000380338

1_138

569.0

Domain

YEATS

Hgene

MLLT3

chr9:20456702

chr9:86928369

ENST00000380338

295_300

569.0

Motif

Nuclear localization signal

Hgene

MLLT3

chr9:20456702

chr9:86928369

ENST00000380338

106_108

569.0

Region

Histone H3K9cr binding

Hgene

MLLT3

chr9:20456702

chr9:86928369

ENST00000380338

106_109

569.0

Region

Inhibitor XL-07i binding

Tgene

SLC28A3

chr9:20456702

chr9:86928369

ENST00000376238

1_102

692.0

Topological domain

Cytoplasmic

Top

Fusion Gene Sequence for MLLT3-SLC28A3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>54299_54299_1_MLLT3-SLC28A3_MLLT3_chr9_20456702_ENST00000380338_SLC28A3_chr9_86928369_ENST00000376238_length(transcript)=5340nt_BP=563nt
GAGGCTCGGAGCCCGGGTGTCAGGCGCCACGGCGCATGCTCCGCAATCATCTTCTTTACCCTGGAGCTGCTGCTGCTGCTGCTGCTTTTG
CTTTTGGGGCTGAGTTTAATAAGCGAGCGAGCGAGCAAGCGAGCGCGGGGGGAAAAAGGCAGAGAATGTCCGCCATCTACCCTCCGCTCC
TGGGCGCGCTCTCATTCATAGCAGCCTCTTCATGAATTACAGCTGAGGGGGGGCGGAGGAGGGGGGGGTACCACACAACACCCCAGCAAA
CCTCCGGGCCCCCAGGCATGGCTAGCTCGTGTGCCGTGCAGGTGAAGCTGGAGCTGGGGCACCGCGCCCAGGTGAGGAAAAAACCCACCG
TGGAGGGCTTCACCCACGACTGGATGGTGTTCGTACGCGGTCCGGAGCACAGTAACATACAGCACTTTGTGGAGAAAGTCGTCTTCCACT
TGCACGAAAGCTTTCCTAGGCCAAAAAGAGTGTGCAAAGATCCACCTTACAAAGTAGAAGAATCTGGGTATGCTGGTTTCATTTTGCCAA
TTGAAGTTTATTTTAAAAACAAGAATGAAGAAAACTTTCTTGAGAACGAGAACACATCAGGAAACAACTCAATAAGAAGCAGAGCTGTGC
AAAGCAGGGAGCACACAAACACCAAACAGGATGAAGAACAGGTCACAGTTGAGCAGGATTCTCCAAGAAACAGAGAACACATGGAGGATG
ATGATGAGGAGATGCAACAAAAAGGGTGTTTGGAAAGGAGGTATGACACAGTATGTGGTTTCTGTAGGAAACACAAAACAACTCTTCGGC
ACATCATCTGGGGCATTTTATTAGCAGGTTATCTGGTTATGGTGATTTCGGCCTGTGTGCTGAACTTTCACAGAGCCCTTCCTCTTTTTG
TGATCACCGTGGCTGCCATCTTCTTTGTTGTCTGGGATCACCTGATGGCCAAATACGAACATCGAATTGATGAGATGCTGTCTCCTGGCA
GAAGGCTTCTAAACAGCCATTGGTTCTGGCTGAAGTGGGTGATCTGGAGCTCCCTGGTCCTAGCAGTTATTTTCTGGTTGGCCTTTGACA
CTGCCAAATTGGGTCAACAGCAGCTGGTGTCCTTCGGTGGGCTCATAATGTACATTGTCCTGTTATTTCTATTTTCCAAGTACCCAACCA
GAGTTTACTGGAGACCTGTCTTATGGGGAATCGGGCTACAGTTTCTTCTTGGGCTCTTGATTCTAAGGACTGACCCTGGATTTATAGCTT
TTGATTGGTTGGGCAGACAAGTTCAGACTTTTCTGGAGTACACAGATGCTGGTGCTTCATTTGTCTTTGGTGAGAAATACAAAGACCACT
TCTTTGCATTTAAGGTCCTGCCGATCGTGGTTTTCTTCAGCACTGTGATGTCCATGCTGTACTACCTGGGACTGATGCAGTGGATTATTA
GAAAGGTTGGATGGATCATGCTAGTTACTACGGGATCATCTCCTATTGAATCTGTAGTTGCTTCTGGCAATATATTTGTTGGACAAACGG
AGTCTCCACTGCTGGTCCGACCATATTTACCTTACATCACCAAGTCTGAACTCCACGCCATCATGACCGCCGGGTTCTCTACCATTGCTG
GAAGCGTGCTAGGTGCATACATTTCTTTTGGGGTTCCATCCTCCCACTTGTTAACAGCGTCAGTTATGTCAGCACCTGCGTCATTGGCTG
CTGCTAAACTCTTTTGGCCTGAGACAGAAAAACCTAAAATAACCCTCAAGAATGCCATGAAAATGGAAAGTGGTGATTCAGGGAATCTTC
TAGAAGCTGCAACACAGGGAGCATCCTCCTCCATCTCCCTGGTGGCCAACATCGCTGTGAATCTGATTGCCTTCCTGGCCCTGCTGTCTT
TTATGAATTCAGCCCTGTCCTGGTTTGGAAACATGTTTGACTACCCACAGCTGAGTTTTGAGCTAATCTGCTCCTACATCTTCATGCCCT
TTTCCTTCATGATGGGAGTGGAATGGCAGGACAGCTTTATGGTTGCCAGACTCATAGGTTATAAGACCTTCTTCAATGAATTTGTGGCTT
ATGAGCACCTCTCAAAATGGATCCACTTGAGGAAAGAAGGTGGACCCAAATTTGTAAACGGTGTGCAGCAATATATATCAATTCGTTCTG
AGATAATCGCCACTTACGCTCTCTGTGGTTTTGCCAATATCGGGTCCCTAGGAATCGTGATCGGCGGACTCACATCCATGGCTCCTTCCA
GAAAGCGTGATATCGCCTCGGGGGCAGTGAGAGCTCTGATTGCGGGGACCGTGGCCTGCTTCATGACAGCCTGCATCGCAGGCATACTCT
CCAGCACTCCTGTGGACATCAACTGCCATCACGTTTTAGAGAATGCCTTCAACTCCACTTTCCCTGGAAACACAACCAAGGTGATAGCTT
GTTGCCAAAGTCTGTTGAGCAGCACTGTTGCCAAGGGTCCTGGTGAAGTCATCCCAGGAGGAAACCACAGTCTGTATTCTTTGAAGGGCT
GCTGCACATTGTTGAATCCATCGACCTTTAACTGCAATGGGATCTCTAATACATTTTGAGGTCAGCCACTTCTCCAGTGGAACTCTGAAG
TACAGATGCTGAATTTTCTGCTTTGGAAAGAAAAAAAAAAGAAGCTATTGTCCACAGATTGATGCTTCCATAATGGAATCAGCTTTAATT
GCAAGGAATGAAGAAAAACAAGAGTGGACCTTCAAAGCTACAACATTTTCCTCCTCCCCTCCCTCCCCACCAGCCCCTTCCCCACCAAGA
ACTGCTATGATGTCCCAAAGTGAGGTGTTGTTGATTCCAGTCTCAATGGGATTTTCTGACTTTAATGTTTGCAAGGCATTTCACCAGAAT
ACAGCTATAAACGGCCGCTCCCAACAACTGGGCTCTGACTCACCCACACCCACTTAGTGTCCACTAAGTAGTCCAGGGTGACTCAGTTTA
AGCACATCTCAGGTGAGGTCACTCTGCATATACCTTGGCTTACCTGAAATAGCCTGAACTTGAATCTCACATAAGGGAAAACTAGTCATC
AATCACCAACTCATTGACTACCCTCAGGAAGTCCTGCAGAAATCAAGAGTCCTTGAGGAGAACACGTGGATCATACCAAAACCAGGGTTT
AAATCCATTCTGCTTAAGAGTTCTATCAGTCAGTTTAACCATAAATTACGCTACAGAAACAAACAACCCAAAAACCTCAGTGGCTTACAG
ATTTATTTTTCACTCACATGTTTGTAATGATCCATCTTGGTTGTAATCCATATTGCTTCAGCACCCAGTCTAAAGGAGCAGCCTCTAAGG
GGGGCATGTTGGTCTTAAGAGGGAAAAGAAAGGTGGGAACCACATGATGGCTCTTTCATCTTCCGCTAGGAAATGATACCCTTTACTTCC
ATGACATTCCATTAGCCAAAACAAGTCCTGTGACAGGCACGATGTCAGTCACCACAGTTAAATTATCCTGTCATAGGGAGGGATAGTGAA
TATTTTGCAGAAGTAATATGATACACCATAAGGGTACATAATATCCATGTCTCCCTTCAAGGAGCCATCCTGTTGTAGGCCATAACGGTA
GGCCTATTCATCTGCACATTTGGTAATGTATTCCTGGTGACAAAGCAGCTACTCTTCAATCAAAAGCCGTGTAAGAAGCAGTTGAGGAAA
AAAAGTCCTGGTTGAGCTCTGAAAACCTTGCGTTGATAATTTCATTGACCAGGATGGCATCAGTATCAAACTTGAAGAATGGGTGTCAGT
GTCTAAGAAAAAGATTCCAGAGACAATGGTGGTGTGCTCTTTAACGAAATGCCCATCACCACTGCTCTTAATAGCATGAAGACCACATGC
TGTGAGAAAACACAAACATCAATTACCAAGTCAAGAAACAGACACTGAATGTGAAAAAGGTTTTGAAATACCTTAAGTAATTTATTTTGT
TTCTATTTTTCCTTCTGTTTGTGTACAAGAGTAATTTAAAAGAAAAAGCTATGTGAAAATAGTTGGGGTTTTTTGTGTGTTTTGTTTTTT
GTGGTGGTGAAGGAGGAGGCCTAATGTCCAGAGGACTGTTTATCCCTGAAGTATGATATACTAAAATATTTCTTATTATTTGTATCAATT
TTCCTTGGAGCTCAATGTGCCCTTGCAGTCTTCAGACTTTATTTTAGGAAAATATATTTGCATGTTTTCCCCCCATTCTCAATGTTTGGT
GTCCTGGTTCATCATACCCCACAGAATGTTATGTTTATGTATCATACCATTCCTCTGTGGACATGCATTTACTTTGTTTACAGGTTTTGG
TTTGGGGGTTCTCTTTTTCCTACTCTGGACAGTGCATGTACATTTACTTTGCATGCTGGTGCTTTTTTTTCTATAGCAATAGTGTCTGAT
AGACATATGCAAGTCACATGTAATTTAAGATCTAGTAGCCACGCTAAAAAACAAGTAAAATTAATTTTAATATATTTAACTCAATACATT
GGAGATATTATTTCAGTAAGATATTTTTCATTCTTATGAAACTAAGTCTGTCTGGTTTGCATATCTCAGTTGAGACACTAAAGTTTTACT
GATAATACTTAATCCATGTTTAGATTTCATAAAATCTAAATTTGCAAAGTAAATTTACATACCCATGTTGGTCTAAATGTGCTTAAAAGT
TTTCCAATAACTGAAATGAGTATCAGTTTTAAATTTAAAAATTTGTTACTTGGTTACTCCATATTTCAGGTATTAGTGGCTACCATATTG
GTCAGAGCAGATTCATAGGATGATTTCCCAGGTTTGAAGTGTGTGTATATTTCTGGTATTATAAGATGTCAGACTGGTTTTTGGAGAAAT
ATGTTGTCTTAATTTTTACCTGCTTTGATATGACCTTTCTGTGTGTACGTGTGACATTTCTTTATAAATGCAACATGTTCACATAGGTCC
TACGTTGATTCCTTATTAATGCTGTGCATCCTTGAACTGAGAAAGGGGGTGTTATTCCTGAGCTATATTATAAGAGGATAGTAAAGGCCA
AGGACCAGGAAAATGAGCTGGTTAAGCCTCTTGAGCTTGTTACCCCCAGAAACCTCACCAATACCCTGTGAACGTCGTAAGTGGCCCTTC
TCCCAGTGAAACAACCTAATGGAGGTTTTTGGTGCATGGTGATGTTTTTATTCCTCTTTAGTAGACATAGAAGCTGGAGGCTGCTTGTCT
TCCCCAGTTTCTCCTTCACCCATGTACATATAGTGGGCAAAGATGGCATGCCTATGTTTTTCAGCTGTTTGAGCCCGCTCACTGTTGACA

>54299_54299_1_MLLT3-SLC28A3_MLLT3_chr9_20456702_ENST00000380338_SLC28A3_chr9_86928369_ENST00000376238_length(amino acids)=763AA_BP=92
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFK
NKNEENFLENENTSGNNSIRSRAVQSREHTNTKQDEEQVTVEQDSPRNREHMEDDDEEMQQKGCLERRYDTVCGFCRKHKTTLRHIIWGI
LLAGYLVMVISACVLNFHRALPLFVITVAAIFFVVWDHLMAKYEHRIDEMLSPGRRLLNSHWFWLKWVIWSSLVLAVIFWLAFDTAKLGQ
QQLVSFGGLIMYIVLLFLFSKYPTRVYWRPVLWGIGLQFLLGLLILRTDPGFIAFDWLGRQVQTFLEYTDAGASFVFGEKYKDHFFAFKV
LPIVVFFSTVMSMLYYLGLMQWIIRKVGWIMLVTTGSSPIESVVASGNIFVGQTESPLLVRPYLPYITKSELHAIMTAGFSTIAGSVLGA
YISFGVPSSHLLTASVMSAPASLAAAKLFWPETEKPKITLKNAMKMESGDSGNLLEAATQGASSSISLVANIAVNLIAFLALLSFMNSAL
SWFGNMFDYPQLSFELICSYIFMPFSFMMGVEWQDSFMVARLIGYKTFFNEFVAYEHLSKWIHLRKEGGPKFVNGVQQYISIRSEIIATY
ALCGFANIGSLGIVIGGLTSMAPSRKRDIASGAVRALIAGTVACFMTACIAGILSSTPVDINCHHVLENAFNSTFPGNTTKVIACCQSLL

--------------------------------------------------------------
>54299_54299_2_MLLT3-SLC28A3_MLLT3_chr9_20456702_ENST00000429426_SLC28A3_chr9_86928369_ENST00000376238_length(transcript)=5142nt_BP=365nt
ATATTTCAGCCGCCGCCGCCGGGAGCTGCGGGCACAGTCCGGGGACGCGGCGAGCAGCCTCGGCGGCCGCACCTCCGCAAAGCGCCGCGG
CCGCTACGATGTGTGCCGTGCAGGTGAAGCTGGAGCTGGGGCACCGCGCCCAGGTGAGGAAAAAACCCACCGTGGAGGGCTTCACCCACG
ACTGGATGGTGTTCGTACGCGGTCCGGAGCACAGTAACATACAGCACTTTGTGGAGAAAGTCGTCTTCCACTTGCACGAAAGCTTTCCTA
GGCCAAAAAGAGTGTGCAAAGATCCACCTTACAAAGTAGAAGAATCTGGGTATGCTGGTTTCATTTTGCCAATTGAAGTTTATTTTAAAA
ACAAGAATGAAGAAAACTTTCTTGAGAACGAGAACACATCAGGAAACAACTCAATAAGAAGCAGAGCTGTGCAAAGCAGGGAGCACACAA
ACACCAAACAGGATGAAGAACAGGTCACAGTTGAGCAGGATTCTCCAAGAAACAGAGAACACATGGAGGATGATGATGAGGAGATGCAAC
AAAAAGGGTGTTTGGAAAGGAGGTATGACACAGTATGTGGTTTCTGTAGGAAACACAAAACAACTCTTCGGCACATCATCTGGGGCATTT
TATTAGCAGGTTATCTGGTTATGGTGATTTCGGCCTGTGTGCTGAACTTTCACAGAGCCCTTCCTCTTTTTGTGATCACCGTGGCTGCCA
TCTTCTTTGTTGTCTGGGATCACCTGATGGCCAAATACGAACATCGAATTGATGAGATGCTGTCTCCTGGCAGAAGGCTTCTAAACAGCC
ATTGGTTCTGGCTGAAGTGGGTGATCTGGAGCTCCCTGGTCCTAGCAGTTATTTTCTGGTTGGCCTTTGACACTGCCAAATTGGGTCAAC
AGCAGCTGGTGTCCTTCGGTGGGCTCATAATGTACATTGTCCTGTTATTTCTATTTTCCAAGTACCCAACCAGAGTTTACTGGAGACCTG
TCTTATGGGGAATCGGGCTACAGTTTCTTCTTGGGCTCTTGATTCTAAGGACTGACCCTGGATTTATAGCTTTTGATTGGTTGGGCAGAC
AAGTTCAGACTTTTCTGGAGTACACAGATGCTGGTGCTTCATTTGTCTTTGGTGAGAAATACAAAGACCACTTCTTTGCATTTAAGGTCC
TGCCGATCGTGGTTTTCTTCAGCACTGTGATGTCCATGCTGTACTACCTGGGACTGATGCAGTGGATTATTAGAAAGGTTGGATGGATCA
TGCTAGTTACTACGGGATCATCTCCTATTGAATCTGTAGTTGCTTCTGGCAATATATTTGTTGGACAAACGGAGTCTCCACTGCTGGTCC
GACCATATTTACCTTACATCACCAAGTCTGAACTCCACGCCATCATGACCGCCGGGTTCTCTACCATTGCTGGAAGCGTGCTAGGTGCAT
ACATTTCTTTTGGGGTTCCATCCTCCCACTTGTTAACAGCGTCAGTTATGTCAGCACCTGCGTCATTGGCTGCTGCTAAACTCTTTTGGC
CTGAGACAGAAAAACCTAAAATAACCCTCAAGAATGCCATGAAAATGGAAAGTGGTGATTCAGGGAATCTTCTAGAAGCTGCAACACAGG
GAGCATCCTCCTCCATCTCCCTGGTGGCCAACATCGCTGTGAATCTGATTGCCTTCCTGGCCCTGCTGTCTTTTATGAATTCAGCCCTGT
CCTGGTTTGGAAACATGTTTGACTACCCACAGCTGAGTTTTGAGCTAATCTGCTCCTACATCTTCATGCCCTTTTCCTTCATGATGGGAG
TGGAATGGCAGGACAGCTTTATGGTTGCCAGACTCATAGGTTATAAGACCTTCTTCAATGAATTTGTGGCTTATGAGCACCTCTCAAAAT
GGATCCACTTGAGGAAAGAAGGTGGACCCAAATTTGTAAACGGTGTGCAGCAATATATATCAATTCGTTCTGAGATAATCGCCACTTACG
CTCTCTGTGGTTTTGCCAATATCGGGTCCCTAGGAATCGTGATCGGCGGACTCACATCCATGGCTCCTTCCAGAAAGCGTGATATCGCCT
CGGGGGCAGTGAGAGCTCTGATTGCGGGGACCGTGGCCTGCTTCATGACAGCCTGCATCGCAGGCATACTCTCCAGCACTCCTGTGGACA
TCAACTGCCATCACGTTTTAGAGAATGCCTTCAACTCCACTTTCCCTGGAAACACAACCAAGGTGATAGCTTGTTGCCAAAGTCTGTTGA
GCAGCACTGTTGCCAAGGGTCCTGGTGAAGTCATCCCAGGAGGAAACCACAGTCTGTATTCTTTGAAGGGCTGCTGCACATTGTTGAATC
CATCGACCTTTAACTGCAATGGGATCTCTAATACATTTTGAGGTCAGCCACTTCTCCAGTGGAACTCTGAAGTACAGATGCTGAATTTTC
TGCTTTGGAAAGAAAAAAAAAAGAAGCTATTGTCCACAGATTGATGCTTCCATAATGGAATCAGCTTTAATTGCAAGGAATGAAGAAAAA
CAAGAGTGGACCTTCAAAGCTACAACATTTTCCTCCTCCCCTCCCTCCCCACCAGCCCCTTCCCCACCAAGAACTGCTATGATGTCCCAA
AGTGAGGTGTTGTTGATTCCAGTCTCAATGGGATTTTCTGACTTTAATGTTTGCAAGGCATTTCACCAGAATACAGCTATAAACGGCCGC
TCCCAACAACTGGGCTCTGACTCACCCACACCCACTTAGTGTCCACTAAGTAGTCCAGGGTGACTCAGTTTAAGCACATCTCAGGTGAGG
TCACTCTGCATATACCTTGGCTTACCTGAAATAGCCTGAACTTGAATCTCACATAAGGGAAAACTAGTCATCAATCACCAACTCATTGAC
TACCCTCAGGAAGTCCTGCAGAAATCAAGAGTCCTTGAGGAGAACACGTGGATCATACCAAAACCAGGGTTTAAATCCATTCTGCTTAAG
AGTTCTATCAGTCAGTTTAACCATAAATTACGCTACAGAAACAAACAACCCAAAAACCTCAGTGGCTTACAGATTTATTTTTCACTCACA
TGTTTGTAATGATCCATCTTGGTTGTAATCCATATTGCTTCAGCACCCAGTCTAAAGGAGCAGCCTCTAAGGGGGGCATGTTGGTCTTAA
GAGGGAAAAGAAAGGTGGGAACCACATGATGGCTCTTTCATCTTCCGCTAGGAAATGATACCCTTTACTTCCATGACATTCCATTAGCCA
AAACAAGTCCTGTGACAGGCACGATGTCAGTCACCACAGTTAAATTATCCTGTCATAGGGAGGGATAGTGAATATTTTGCAGAAGTAATA
TGATACACCATAAGGGTACATAATATCCATGTCTCCCTTCAAGGAGCCATCCTGTTGTAGGCCATAACGGTAGGCCTATTCATCTGCACA
TTTGGTAATGTATTCCTGGTGACAAAGCAGCTACTCTTCAATCAAAAGCCGTGTAAGAAGCAGTTGAGGAAAAAAAGTCCTGGTTGAGCT
CTGAAAACCTTGCGTTGATAATTTCATTGACCAGGATGGCATCAGTATCAAACTTGAAGAATGGGTGTCAGTGTCTAAGAAAAAGATTCC
AGAGACAATGGTGGTGTGCTCTTTAACGAAATGCCCATCACCACTGCTCTTAATAGCATGAAGACCACATGCTGTGAGAAAACACAAACA
TCAATTACCAAGTCAAGAAACAGACACTGAATGTGAAAAAGGTTTTGAAATACCTTAAGTAATTTATTTTGTTTCTATTTTTCCTTCTGT
TTGTGTACAAGAGTAATTTAAAAGAAAAAGCTATGTGAAAATAGTTGGGGTTTTTTGTGTGTTTTGTTTTTTGTGGTGGTGAAGGAGGAG
GCCTAATGTCCAGAGGACTGTTTATCCCTGAAGTATGATATACTAAAATATTTCTTATTATTTGTATCAATTTTCCTTGGAGCTCAATGT
GCCCTTGCAGTCTTCAGACTTTATTTTAGGAAAATATATTTGCATGTTTTCCCCCCATTCTCAATGTTTGGTGTCCTGGTTCATCATACC
CCACAGAATGTTATGTTTATGTATCATACCATTCCTCTGTGGACATGCATTTACTTTGTTTACAGGTTTTGGTTTGGGGGTTCTCTTTTT
CCTACTCTGGACAGTGCATGTACATTTACTTTGCATGCTGGTGCTTTTTTTTCTATAGCAATAGTGTCTGATAGACATATGCAAGTCACA
TGTAATTTAAGATCTAGTAGCCACGCTAAAAAACAAGTAAAATTAATTTTAATATATTTAACTCAATACATTGGAGATATTATTTCAGTA
AGATATTTTTCATTCTTATGAAACTAAGTCTGTCTGGTTTGCATATCTCAGTTGAGACACTAAAGTTTTACTGATAATACTTAATCCATG
TTTAGATTTCATAAAATCTAAATTTGCAAAGTAAATTTACATACCCATGTTGGTCTAAATGTGCTTAAAAGTTTTCCAATAACTGAAATG
AGTATCAGTTTTAAATTTAAAAATTTGTTACTTGGTTACTCCATATTTCAGGTATTAGTGGCTACCATATTGGTCAGAGCAGATTCATAG
GATGATTTCCCAGGTTTGAAGTGTGTGTATATTTCTGGTATTATAAGATGTCAGACTGGTTTTTGGAGAAATATGTTGTCTTAATTTTTA
CCTGCTTTGATATGACCTTTCTGTGTGTACGTGTGACATTTCTTTATAAATGCAACATGTTCACATAGGTCCTACGTTGATTCCTTATTA
ATGCTGTGCATCCTTGAACTGAGAAAGGGGGTGTTATTCCTGAGCTATATTATAAGAGGATAGTAAAGGCCAAGGACCAGGAAAATGAGC
TGGTTAAGCCTCTTGAGCTTGTTACCCCCAGAAACCTCACCAATACCCTGTGAACGTCGTAAGTGGCCCTTCTCCCAGTGAAACAACCTA
ATGGAGGTTTTTGGTGCATGGTGATGTTTTTATTCCTCTTTAGTAGACATAGAAGCTGGAGGCTGCTTGTCTTCCCCAGTTTCTCCTTCA
CCCATGTACATATAGTGGGCAAAGATGGCATGCCTATGTTTTTCAGCTGTTTGAGCCCGCTCACTGTTGACAGATTGTTGCTGTTGGTCT

>54299_54299_2_MLLT3-SLC28A3_MLLT3_chr9_20456702_ENST00000429426_SLC28A3_chr9_86928369_ENST00000376238_length(amino acids)=760AA_BP=89
MCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKN
EENFLENENTSGNNSIRSRAVQSREHTNTKQDEEQVTVEQDSPRNREHMEDDDEEMQQKGCLERRYDTVCGFCRKHKTTLRHIIWGILLA
GYLVMVISACVLNFHRALPLFVITVAAIFFVVWDHLMAKYEHRIDEMLSPGRRLLNSHWFWLKWVIWSSLVLAVIFWLAFDTAKLGQQQL
VSFGGLIMYIVLLFLFSKYPTRVYWRPVLWGIGLQFLLGLLILRTDPGFIAFDWLGRQVQTFLEYTDAGASFVFGEKYKDHFFAFKVLPI
VVFFSTVMSMLYYLGLMQWIIRKVGWIMLVTTGSSPIESVVASGNIFVGQTESPLLVRPYLPYITKSELHAIMTAGFSTIAGSVLGAYIS
FGVPSSHLLTASVMSAPASLAAAKLFWPETEKPKITLKNAMKMESGDSGNLLEAATQGASSSISLVANIAVNLIAFLALLSFMNSALSWF
GNMFDYPQLSFELICSYIFMPFSFMMGVEWQDSFMVARLIGYKTFFNEFVAYEHLSKWIHLRKEGGPKFVNGVQQYISIRSEIIATYALC
GFANIGSLGIVIGGLTSMAPSRKRDIASGAVRALIAGTVACFMTACIAGILSSTPVDINCHHVLENAFNSTFPGNTTKVIACCQSLLSST

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MLLT3-SLC28A3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MLLT3-SLC28A3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MLLT3-SLC28A3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source