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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MLLT3-SOD2 (FusionGDB2 ID:54300)

Fusion Gene Summary for MLLT3-SOD2

check button Fusion gene summary
Fusion gene informationFusion gene name: MLLT3-SOD2
Fusion gene ID: 54300
HgeneTgene
Gene symbol

MLLT3

SOD2

Gene ID

4300

100129518

Gene nameMLLT3 super elongation complex subunitSOD2 overlapping transcript 1
SynonymsAF9|YEATS3SOD2
Cytomap

9p21.3

6q25.3

Type of geneprotein-codingncRNA
Descriptionprotein AF-9ALL1-fused gene from chromosome 9 proteinKMT2A/MLLT3 fusionKMT2A/MLLT3 fusion proteinYEATS domain-containing protein 3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3myeloid/lymphoid or mixed-lineage leuSuperoxide dismutase [Mn], mitochondrial
Modification date2020032720200313
UniProtAcc

P42568

.
Ensembl transtripts involved in fusion geneENST00000380338, ENST00000429426, 
ENST00000355930, ENST00000475957, 
ENST00000380321, 		ENST00000337404, 
ENST00000367054, ENST00000444946, 
ENST00000452684, ENST00000535372, 
ENST00000367055, ENST00000538183, 
ENST00000546087, 
Fusion gene scores* DoF score18 X 14 X 11=277213 X 22 X 6=1716
# samples 2522
** MAII scorelog2(25/2772*10)=-3.47092725747513
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/1716*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MLLT3 [Title/Abstract] AND SOD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMLLT3(20620653)-SOD2(160109274), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMLLT3

GO:0045893

positive regulation of transcription, DNA-templated

25417107|27105114

HgeneMLLT3

GO:0090090

negative regulation of canonical Wnt signaling pathway

19591803


check buttonFusion gene breakpoints across MLLT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SOD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A48C-01AMLLT3chr9

20620653

-SOD2chr6

160109274

-


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Fusion Gene ORF analysis for MLLT3-SOD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000380338ENST00000337404MLLT3chr9

20620653

-SOD2chr6

160109274

-
5CDS-intronENST00000380338ENST00000367054MLLT3chr9

20620653

-SOD2chr6

160109274

-
5CDS-intronENST00000380338ENST00000444946MLLT3chr9

20620653

-SOD2chr6

160109274

-
5CDS-intronENST00000380338ENST00000452684MLLT3chr9

20620653

-SOD2chr6

160109274

-
5CDS-intronENST00000380338ENST00000535372MLLT3chr9

20620653

-SOD2chr6

160109274

-
5CDS-intronENST00000429426ENST00000337404MLLT3chr9

20620653

-SOD2chr6

160109274

-
5CDS-intronENST00000429426ENST00000367054MLLT3chr9

20620653

-SOD2chr6

160109274

-
5CDS-intronENST00000429426ENST00000444946MLLT3chr9

20620653

-SOD2chr6

160109274

-
5CDS-intronENST00000429426ENST00000452684MLLT3chr9

20620653

-SOD2chr6

160109274

-
5CDS-intronENST00000429426ENST00000535372MLLT3chr9

20620653

-SOD2chr6

160109274

-
5UTR-3CDSENST00000355930ENST00000367055MLLT3chr9

20620653

-SOD2chr6

160109274

-
5UTR-3CDSENST00000355930ENST00000538183MLLT3chr9

20620653

-SOD2chr6

160109274

-
5UTR-3CDSENST00000355930ENST00000546087MLLT3chr9

20620653

-SOD2chr6

160109274

-
5UTR-3CDSENST00000475957ENST00000367055MLLT3chr9

20620653

-SOD2chr6

160109274

-
5UTR-3CDSENST00000475957ENST00000538183MLLT3chr9

20620653

-SOD2chr6

160109274

-
5UTR-3CDSENST00000475957ENST00000546087MLLT3chr9

20620653

-SOD2chr6

160109274

-
5UTR-intronENST00000355930ENST00000337404MLLT3chr9

20620653

-SOD2chr6

160109274

-
5UTR-intronENST00000355930ENST00000367054MLLT3chr9

20620653

-SOD2chr6

160109274

-
5UTR-intronENST00000355930ENST00000444946MLLT3chr9

20620653

-SOD2chr6

160109274

-
5UTR-intronENST00000355930ENST00000452684MLLT3chr9

20620653

-SOD2chr6

160109274

-
5UTR-intronENST00000355930ENST00000535372MLLT3chr9

20620653

-SOD2chr6

160109274

-
5UTR-intronENST00000475957ENST00000337404MLLT3chr9

20620653

-SOD2chr6

160109274

-
5UTR-intronENST00000475957ENST00000367054MLLT3chr9

20620653

-SOD2chr6

160109274

-
5UTR-intronENST00000475957ENST00000444946MLLT3chr9

20620653

-SOD2chr6

160109274

-
5UTR-intronENST00000475957ENST00000452684MLLT3chr9

20620653

-SOD2chr6

160109274

-
5UTR-intronENST00000475957ENST00000535372MLLT3chr9

20620653

-SOD2chr6

160109274

-
In-frameENST00000380338ENST00000367055MLLT3chr9

20620653

-SOD2chr6

160109274

-
In-frameENST00000380338ENST00000538183MLLT3chr9

20620653

-SOD2chr6

160109274

-
In-frameENST00000380338ENST00000546087MLLT3chr9

20620653

-SOD2chr6

160109274

-
In-frameENST00000429426ENST00000367055MLLT3chr9

20620653

-SOD2chr6

160109274

-
In-frameENST00000429426ENST00000538183MLLT3chr9

20620653

-SOD2chr6

160109274

-
In-frameENST00000429426ENST00000546087MLLT3chr9

20620653

-SOD2chr6

160109274

-
intron-3CDSENST00000380321ENST00000367055MLLT3chr9

20620653

-SOD2chr6

160109274

-
intron-3CDSENST00000380321ENST00000538183MLLT3chr9

20620653

-SOD2chr6

160109274

-
intron-3CDSENST00000380321ENST00000546087MLLT3chr9

20620653

-SOD2chr6

160109274

-
intron-intronENST00000380321ENST00000337404MLLT3chr9

20620653

-SOD2chr6

160109274

-
intron-intronENST00000380321ENST00000367054MLLT3chr9

20620653

-SOD2chr6

160109274

-
intron-intronENST00000380321ENST00000444946MLLT3chr9

20620653

-SOD2chr6

160109274

-
intron-intronENST00000380321ENST00000452684MLLT3chr9

20620653

-SOD2chr6

160109274

-
intron-intronENST00000380321ENST00000535372MLLT3chr9

20620653

-SOD2chr6

160109274

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000380338MLLT3chr920620653-ENST00000546087SOD2chr6160109274-1122480287922211
ENST00000380338MLLT3chr920620653-ENST00000538183SOD2chr6160109274-14359480287922211
ENST00000380338MLLT3chr920620653-ENST00000367055SOD2chr6160109274-1177480287922211
ENST00000429426MLLT3chr920620653-ENST00000546087SOD2chr6160109274-92428298724208
ENST00000429426MLLT3chr920620653-ENST00000538183SOD2chr6160109274-1416128298724208
ENST00000429426MLLT3chr920620653-ENST00000367055SOD2chr6160109274-97928298724208

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000380338ENST00000546087MLLT3chr920620653-SOD2chr6160109274-0.0062265190.9937735
ENST00000380338ENST00000538183MLLT3chr920620653-SOD2chr6160109274-0.0027174320.9972825
ENST00000380338ENST00000367055MLLT3chr920620653-SOD2chr6160109274-0.0046202890.9953797
ENST00000429426ENST00000546087MLLT3chr920620653-SOD2chr6160109274-0.0013492690.9986507
ENST00000429426ENST00000538183MLLT3chr920620653-SOD2chr6160109274-0.0013889930.998611
ENST00000429426ENST00000367055MLLT3chr920620653-SOD2chr6160109274-0.0012129910.998787

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Fusion Genomic Features for MLLT3-SOD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MLLT3-SOD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:20620653/chr6:160109274)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MLLT3

P42568

.
FUNCTION: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114, PubMed:30385749). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (PubMed:25417107). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than confering, HSC stemness (PubMed:31776511). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PubMed:31776511). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:27545619, ECO:0000269|PubMed:30374167, ECO:0000269|PubMed:30385749, ECO:0000269|PubMed:31776511}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMLLT3chr9:20620653chr6:160109274ENST00000380338-21156_5864569.0RegionInhibitor XL-07i binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMLLT3chr9:20620653chr6:160109274ENST00000380338-211149_19464569.0Compositional biasNote=Poly-Ser
HgeneMLLT3chr9:20620653chr6:160109274ENST00000380338-211383_39164569.0Compositional biasNote=Poly-Ser
HgeneMLLT3chr9:20620653chr6:160109274ENST00000380338-211466_46964569.0Compositional biasNote=Poly-Pro
HgeneMLLT3chr9:20620653chr6:160109274ENST00000380338-2111_13864569.0DomainYEATS
HgeneMLLT3chr9:20620653chr6:160109274ENST00000380338-211295_30064569.0MotifNuclear localization signal
HgeneMLLT3chr9:20620653chr6:160109274ENST00000380338-211106_10864569.0RegionHistone H3K9cr binding
HgeneMLLT3chr9:20620653chr6:160109274ENST00000380338-211106_10964569.0RegionInhibitor XL-07i binding
HgeneMLLT3chr9:20620653chr6:160109274ENST00000380338-21178_8064569.0RegionHistone H3K9cr binding


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Fusion Gene Sequence for MLLT3-SOD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54300_54300_1_MLLT3-SOD2_MLLT3_chr9_20620653_ENST00000380338_SOD2_chr6_160109274_ENST00000367055_length(transcript)=1177nt_BP=480nt
GAGGCTCGGAGCCCGGGTGTCAGGCGCCACGGCGCATGCTCCGCAATCATCTTCTTTACCCTGGAGCTGCTGCTGCTGCTGCTGCTTTTG
CTTTTGGGGCTGAGTTTAATAAGCGAGCGAGCGAGCAAGCGAGCGCGGGGGGAAAAAGGCAGAGAATGTCCGCCATCTACCCTCCGCTCC
TGGGCGCGCTCTCATTCATAGCAGCCTCTTCATGAATTACAGCTGAGGGGGGGCGGAGGAGGGGGGGGTACCACACAACACCCCAGCAAA
CCTCCGGGCCCCCAGGCATGGCTAGCTCGTGTGCCGTGCAGGTGAAGCTGGAGCTGGGGCACCGCGCCCAGGTGAGGAAAAAACCCACCG
TGGAGGGCTTCACCCACGACTGGATGGTGTTCGTACGCGGTCCGGAGCACAGTAACATACAGCACTTTGTGGAGAAAGTCGTCTTCCACT
TGCACGAAAGCTTTCCTAGGCCAAAAAGAGGAGATGTTACAGCCCAGATAGCTCTTCAGCCTGCACTGAAGTTCAATGGTGGTGGTCATA
TCAATCATAGCATTTTCTGGACAAACCTCAGCCCTAACGGTGGTGGAGAACCCAAAGGGGAGTTGCTGGAAGCCATCAAACGTGACTTTG
GTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTTGGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAAC
GGGGACACTTACAAATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTGGGGATTGATGTGTGGG
AGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTATCTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAA
GATACATGGCTTGCAAAAAGTAAACCACGATCGTTATGCTGATCATACCCTAATGATCCCAGCAAGATAATGTCCTGTCTTCTAAGATGT
GCATCAAGCCTGGTACATACTGAAAACCCTATAAGGTCCTGGATAATTTTTGTTTGATTATTCATTGAAGAAACATTTATTTTCCAATTG
TGTGAAGTTTTTGACTGTTAATAAAAGAATCTGTCAACCATCAAAGAGGTCTGCATTATGCTTGCATGTCAAAAACTTTAAAAATCCTAT

>54300_54300_1_MLLT3-SOD2_MLLT3_chr9_20620653_ENST00000380338_SOD2_chr6_160109274_ENST00000367055_length(amino acids)=211AA_BP=64
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRGDVTAQIALQPALKFNGGGHINHSIF
WTNLSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYL

--------------------------------------------------------------
>54300_54300_2_MLLT3-SOD2_MLLT3_chr9_20620653_ENST00000380338_SOD2_chr6_160109274_ENST00000538183_length(transcript)=14359nt_BP=480nt
GAGGCTCGGAGCCCGGGTGTCAGGCGCCACGGCGCATGCTCCGCAATCATCTTCTTTACCCTGGAGCTGCTGCTGCTGCTGCTGCTTTTG
CTTTTGGGGCTGAGTTTAATAAGCGAGCGAGCGAGCAAGCGAGCGCGGGGGGAAAAAGGCAGAGAATGTCCGCCATCTACCCTCCGCTCC
TGGGCGCGCTCTCATTCATAGCAGCCTCTTCATGAATTACAGCTGAGGGGGGGCGGAGGAGGGGGGGGTACCACACAACACCCCAGCAAA
CCTCCGGGCCCCCAGGCATGGCTAGCTCGTGTGCCGTGCAGGTGAAGCTGGAGCTGGGGCACCGCGCCCAGGTGAGGAAAAAACCCACCG
TGGAGGGCTTCACCCACGACTGGATGGTGTTCGTACGCGGTCCGGAGCACAGTAACATACAGCACTTTGTGGAGAAAGTCGTCTTCCACT
TGCACGAAAGCTTTCCTAGGCCAAAAAGAGGAGATGTTACAGCCCAGATAGCTCTTCAGCCTGCACTGAAGTTCAATGGTGGTGGTCATA
TCAATCATAGCATTTTCTGGACAAACCTCAGCCCTAACGGTGGTGGAGAACCCAAAGGGGAGTTGCTGGAAGCCATCAAACGTGACTTTG
GTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTTGGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAAC
GGGGACACTTACAAATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTGGGGATTGATGTGTGGG
AGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTATCTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAA
GATACATGGCTTGCAAAAAGTAAACCACGATCGTTATGCTGAGTATGTTAAGCTCTTTATGACTGTTTTTGTAGTGGTATAGAGTACTGC
AGAATACAGTAAGCTGCTCTATTGTAGCATTTCTTGATGTTGCTTAGTCACTTATTTCATAAACAACTTAATGTTCTGAATAATTTCTTA
CTAAACATTTTGTTATTGGGCAAGTGATTGAAAATAGTAAATGCTTTGTGTGATTGAATCTGATTGGACATTTTCTTCAGAGAGCTAAAT
TACAATTGTCATTTATAAAACCATCAAAAATATTCCATCCATATACTTTGGGGACTTGTAGGGATGCCTTTCTAGTCCTATTCTATTGCA
GTTATAGAAAATCTAGTCTTTTGCCCCAGTTACTTAAAAATAAAATATTAACACTTTCCCAAGGGAAACACTCGGCTTTCTATAGAAAAT
TGCACTTTTTGTCGAGTAATCCTCTGCAGTGATACTTCTGGTAGATGTCACCCAGTGGTTTTTGTTAGGTCAAATGTTCCTGTATAGTTT
TTGCAAATAGAGCTGTATACTGTTTAAATGTAGCAGGTGAACTGAACTGGGGTTTGCTCACCTGCACAGTAAAGGCAAACTTCAACAGCA
AAACTGCAAAAAGGTGGTTTTTGCAGTAGGAGAAAGGAGGATGTTTATTTGCAGGGCGCCAAGCAAGGAGAATTGGGCAGCTCATGCTTG
AGACCCAATCTCCATGATGACCTACAAGCTAGAGTATTTAAAGGCAGTGGTAAATTTCAGGAAAGCAGAAGTTAAAGGCAAAATTGTAAA
TCAGTCGAGATCGGGTGCCTTCAGGGTGGTATGGCTGTATACCAAAATTGTAAATCACTACATGAAGCTTATATATTGGTTTGGCCTGAA
AGGTGAAGTGGGGTAGGCAGGGGGCGGGCTTACAGGTTATGGTGGATTCAAAGACTCCCTGATTTGTGATTGGTTAAGGAAGCAAAGCTT
TGTCTAAAAACTTGGGGTCCGCAGAAAGGAACATTAAGGTCTGGCCAGGCCCCTCAGGAAGAAACTGAGAGCAAAGAATGGAGGTCAGAG
TTTAGTCCCTGGTGTTCCCCCTTATCTGACGTCTGTGTGAATCCATTTGGTGGGGGTCTGGGTTTCTGAAAAGTAGCTCAGGGGCACGTG
TTAAGGATGTCTCTAGGTGACTCTAACTTCCCTGGCTATTGTTTGAAACTGTTATGACCTTCTTGCTTATCAGCTTGCTGGTTTCCTTCT
CGGGGCGAGCTGGGTGCCTGGAGTTTTCGGTGAAGGAAACTCAAGATTCTCCTTTATTTCTGTGCTTGTGGGAATCCCCCTGGCACACCC
CAAAGAGGGGTCCCTGCTCCGTCTCACAGGGATCTTTTTGTATATTTGGCTTAGCATCATACATTTGCCATGTTGTTTCATCATCTGCCT
AATTTACTGTTTTTGAATATTTCATTTGTTTCTAATTGTTACTACAGATAATGCTGGGGTGAGCAACTCTGTGTACATAGGTTTATCTCC
TATTGGAATATTTTCTTTATATAGGCGTTTTTTTTTTTTCTTTTTTTTTGGAGACAGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGT
GGCGCGACCGGAGCTCACTGCAACCTCCACTTCCCGGGTTCAAGTGATTGTCCCACCTCAGCCTCCTGAATAGCTGGGATTACAGGTGCA
TGCTACCATGCCTGGCTACTTTTTGTATTTTTAGCAGAGACAGGGTTTCACCATGTTGGCCAGGGTGGTCTCGAACTCCTGACCTCAAGT
GATCCGTCTGGCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCTGGCCTATATAGGCTTTTTTCTTAAACCTATTT
AGTAATGTTTTCCCAAGTTTATTTTTTATTTTTAATTTTTTCCCCAAGTTTATTTTTCTATTTTTTTTTCATGGAAAAATGGGGTAACTT
AGCAGTTTCAATATTGAAGACTGAAGTTTAAAAAAAATTTAAATTCAAGGTACTTTTAAAATTCAGTTAGAAAAGTAGGCTTTAAAAATT
ATTAGAGACAAGAGTACCAAAGCGGTGTGTGTATGTGTGTGTGTGTATGCATGCTTGTGGATTGGAAAAACTTTGGAGACTGATTACTTT
TCATTATATATGTGTCACAGTGAAACAGCTTTTATGTGTCATGTAAGATTACTGCTTGCCTCTCTAAGGAAGGTCGTGACTGTTTAAATA
GACGGGCAAGGTGGAACCTTTTGAAAGATGAGCTTTTGAATATAAGTTGTCTGCTAGATCATGGTTTGTATTGAACTAACAAGGTTTGCA
GATCTGCTGACTTATATAAAGCTTTTTGATTCCTACTAAGCTTTAAGATTTAAAAAATGTTCAATGTTGAAATTTCTGTGGGGCTCTATT
TTTGCTTTGGCTTTCTGGTGAGAGAGTGAGGAAGCATTCTTTCCTTCACTAAGTTTGTCTTTCTTGTCTTCTGGATAGATTGATTTTAAG
AGACTAAGGGAATTTACAAACTAAAGATTTTAGTCATCTGGTGGAAAAGGAGACTTTAAGATTGTTTAGGGCTGGGCGGGGTGACTCACA
TCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGAACACTTGAAGGAGTTCAAGACCAGCGTGGCCAACGTGGTGAAACCCTGTCT
CTACTAAAAATACAAAAATTGTTTAGCTCTGTTTTTCATAATAGAAATAGAAAAGGTAAAATTGCTTTTCTTCTGAAAAGAACAAGTATT
GTTCATCCAAGAAGGGTTTTTGTGACTGAATCAGCAGTGCCTGCCCTAGTCATAGCTGTGCTTCAAAAACCTCAGCATGATTAGTGTTGG
AGCAAAACAAGGAAGCAAAGCAAATACTGTTTTTGAAATTCTATCTGTTGCTTGAACTATTTTGTAATAATTAAACTTTGATGTTGAGAA
ATCACAACTTTATTGTACACTTCATTGCAACTTGAAATTCATGGTCTTAAAGTGAGATTTGAATTTCTATTGAGCGCCTTTAAAAAAGTA
ATACCAAACCATAAAGTTAAAATCTATGTATATTGAGTCATATCTAAAACCACGTATAAACATAAATTGTATTTCCTGTTTTAATTCCAG
GGGAAGTACTGTTTGGGAAAGCTATTATTAGGTAAATGTTTTACAAATTACTGTTTCTCACTTTCAGTCATACCCTAATGATCCCAGCAA
GATAATGTCCTGTCTTCTAAGATGTGCATCAAGCCTGGTACATACTGAAAACCCTATAAGGTCCTGGATAATTTTTGTTTGATTATTCAT
TGAAGAAACATTTATTTTCCAATTGTGTGAAGTTTTTGACTGTTAATAAAAGAATCTGTCAACCATCAAAGAGGTCTGCATTATGCTTGC
ATGTCAAAAACTTTAAAAATCCTATAATCTTCTGTCATTTTCACTGAGTTTCCATGGGAAAGGAATAGTAAATAATGGGTAGTTGAAATA
TTACTCTTAAGACCAAGACCTGTATCTCCAGTCATATCTGTAATAACATCATCTGATAACCTAAAAGCATAGTATTAGGGATATACGACA
AAACCAAAGTGTTTTTGCTGTTGTCACATACCACTCAATACTTTTACACCAGGTTGTCCAGTGGACACCAGCTGGATGTCCTATAATTCA
ATTCTGACACTGTCTACCTGGAATTGGAGTCAGATCCCACAGGTGGAGGGCTCAGCCCACAAGACTGCCCCCACTCCAGATACCAATCGC
AAGTCCCTATACTTCTGACTGGCTATAAAGTGGGGTTCCCGTGACCCTTTCCTTGGTTTTGATTTATTTGCTAGAGCAGCTCCCAGAACA
CAGAGAAACACTCTACTTATGTTTACCCATTTTTAATTTTATTACTTTATTAAAACTACATATTGGTTACAATACTAATTTATTGTAAAG
GATATTTCATTTATTTATTTTTTTATTTAGAGATGGAGTCTCACTGTGTCACCCAGGCTGGAGTGCGGTGGCACAGTCTCAACTCACTGC
AACCTCCACCTCCTGAGTTCAAGCGATTCTCATGCCTCAGCCTCCCAAGTAGCTGGGATTACAAGTGTGCACCACCATGCCCAGCTAATT
TTTGTATTTTTAGTAGAGATGGGGTTTCACTCTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTCATCCACCCACCTCAGCCTCC
CAAAGTGCTGAGATTACAGGTGTGAGCCATTGCCTCTGGCTTGTAAAGGATATTTCAAAGAATACAGATGAACAGCCAGATGGAAGAGAT
GCACAGGGCAAGGCATGTGGGAAGGGGTATGGAGCTTTCATGCTCTCTCCACGTCATCAGCTACCCAGAAGCTCATCTGGACCCCGACCC
TTTGGGGTTTTACGGAGGCTTCATTATGTCAGCATTACCATTGGCAATTGGCGATTAACTCAACCTTCAGCCTCTCTCCCCTTTCTGGAG
GTTGGGGGTTGAGGCTGGGAGTCCAAACCCTCCAATCTTGCCTTGGTCTTTCTGGTAAGCAGCCCCCCGTCCTGAAGCTACCTAGAGGCT
CCCAGCCACCAATCATTTCATTGGCAAACCAAAGATACTTCAAGGGGTTTAGGAGCCAAGAGACCAAGCAAGGATTGAGACAATATATAT
ATTTCTTATAAATAACATGATCACAAATAGTATTTTATATATTTCTCATAATAGCTGGTTGTGGTTACTCACACCTATCATCCCAGCTAC
TAAGAAGCTAAGGCAGGAGGATCACAGGCCCAGGAGTTTGCAGCTGTAGTGAGCTATGATTGTGCTACTGCACTCCAGCCTGGGTGACAG
TGTGAGACCCTGTCTCTTAAAGTTCTTGTAACATCTTAGAACATTAACCAACCACAGATTATTGCCTTAACTCTGAAAAATAAAGTAATC
ATACTTTTACAAGATGTATTTTACATAAAGTTCTGGTGATATTTTACTCTGGTCATTGGAATATAGGAGCTTACCACCTGGTACCACTCT
TCCTAAAGTGGTATACTATTTGGTATAGTACTGGCATACTATTTGGAAAGGGATGTGAAGTTGGCATGACCTGTCTAGGGTGAAGTCATG
CTGTCTGCTATTCATTGTGGGCTTTACAGTAATGAGAGTGCTTCTGTTGTCAAGATGCTTCTGGGACACGTTAAAAAAAATTTAAGATTT
CTCAGTTTGTGAAAAGGAAGGAGCACGAATGCTTTCAAGTTCCTATGACATGCTAGTCATCTTTCAGTGTGTCCCATTGTTGCACCCAGT
AGTCTCGATGCCCAGCGTCACGGTGATTCCAAGTTTGCCTCTCTGCCCACTATAATTTGTGCTCCATGAAGTCCCAGGACATGAGGTTCT
TGTTCATTTGTGCGTCTGGGCCCATATCCAAATATTAAACAATGTGACTTAATGTATTTATCATATTGTAAATATGGGTATCCCCAAGGC
TCAGAAGTTAACACAGCATATCCACAGAGAGGTTTGACAGCATGGCTGTGGTGACTGGGAAGGCCTTATGCTTGCTCCTCCTTCTGCTGC
TTGCCTTTGTGTGGGCATGGAAAGAACATTGAATTAGGTACTGGAAGACCTGGGTCCTGGTCTTGGAGATTTTACCAGAGCACCTGTGGG
ATATTGGTCAAGATGCCTGGTTTTAGTCCTGCTCCTTTGCTGTGAAAGAGGATCTTAAGGTGCCAACTCTGGCATTTTATTTTTTACTTA
TTTATTTTTAAATTATACTTTAAGTTCTAGGGTACATGTGTACAACATGCAGGTTTGTTACATGTATACATGTGCCATGTTGGTGTGCTG
CACCTATTAACTCGTCATTTACATTAGGTATATCTCCTAATGCTATCCCTCCCCCTTCTCCCCACCCCTCGACAGGCCCCGGTGTGTGAT
GTTCCCCTTCCTGTGTCCAAGTGTTCTCATTGTTCAATTCCCATCTATGAGTGAGAACATGCGGTGTTTGTTTTTTTGTCCTTGGAATAG
TTTGCTGAGAAGGATGGTTTCCAGCTTCATCCATGTCCCTATAAAGGACATGAACTCTTCCTTTTTTATGGCTGCATAGTATTCCATGGT
GTATATGTGCCACATCTTCTTAAACCAATCTATCATTGATGGACATTTGGGTTGGTTCCAAGTCTTTGCTATTGTGAACAGTGCCACAAT
AAATATACGTGTGCATGTGTCTTTATAGCAGCATGATTTATAATCCTTTGGGTATATACCCAGTAATGGGATGGCTGGGTCAAATGGTAT
TTCTAGTTCTAGATCCCTGAGGAATCGCCACACTGTCTTCCACAATGGTTGAACTAGTTTACAGTCCCACCACCAGTGTAAAAGTGTTCC
TATTTCTCCACATCCTCTCCAGCACCTGTTGTTTCCTGACTTTTTAATGATTGACATTCTAACTGGTGTGAGATGGTATCTCATTGTGGT
TTTGATTTGCATTTCTCTGATGGCCCATGATGATGAGCATTTTTTTCATGTGTCTGTTGGATGCATGGATGTCTTCTTTTGAGAAGTGTC
TCTTCATATCCTTCACCTACTTTTTGATGGGGTTTGTTTTTTTCTTGTAAGTTTGTTTGAGTTCCTTGTAGATTCTGGATATTAGCCCTT
TGTCAGATGAGTAGATTGCAAAAATTTTCTCCCATTTTGTAGGTTGCCTGTTCACTCTGATGGTAGTTTCTTTTGCTGTGCAGAAGCTCT
TGAGTTTAATGAGATCCCATTTGTCAATTTTGGCTTCTGTTGCCATTGCTTTTGGTGTTTTAGACATGAAGTCCTTGCCCATGCCTGTGT
CCTGAATGGTACTGCATAGGTTTTCTTCTAGGGTTTTTATGGTTTTAGGTCTAACATTTAAGTCTTTAATCCATCTTGAATTAATTTTTG
TATAAGGTGTAAGGAAGGGATCCAGTTTCAGCTTTCTACATGTGGCTAGCCAGTTTTCCCAGCACCATTTATTAAATAGGGAATCCTTTC
CCCATTTCTTGTTTTTGTCAGGTTTCTCAAAGATCAGATAGTTGTAGATGTGTGGTATTATTTCTGAGGGCTCTGTTCTGTTCCATTGGT
CTATATCTCTGTTTTGGTACTAGTACCATGCTGTTTTGGTTACTGCAGCCTTGTAGTATAGTTTGAAATCAGGTAGCGTGATGCCTCCAG
CTTTGTTCTTTTGGCTTAGGATCGTTTTGGCAGTGCAGGCTCTTTTTTGGTTCCACATGAACTTTAAAGTAGTTTTTTCCAATTCTATGA
AGAAAGTCATGGGTAGCTTGATGGGGATGGCATTGAATCTATAAATTACCTTGGGCAGTATAGCCATTTTCACGATATTGATTCTTCCTA
TCCATGAGCATGGAATGTTCTTCCATTTGTTTGTGTCCTCTTTTATTTCCTTGAGCAGTGGTTTGTAGTTCTCCTTGAAGAGGTCCTTCA
CATCCCTTGTAAGTTGGATTCCTAGGTATTTTATTCTCTTTGAGGCAGTTGTGAATGGGAGTTCACTCATGATTTGGCTCTCTGTTTGTC
TGTTGTTGGTGTATAAGAATGCTTGTGATTTTTGCACATTGATTTTGTATCCTGAGATTTTGCTGAAGTTGCTTATCAAATTAAGGAGAT
TTTGGGCTGAGATGATGGGGTTTTCTAAATATAAAATCATGTCATCTGCAAACAGGGACAATTTGACTTCCTCTTTTCCTTATTGAATAC
CCTTTATTTCTTTCTCCTGCCTGATGGCCCTGGCCAGAACTTCCAACACTATGTTGAATAGGAGTGGTGAGAGAGGGCATCCCTGTCTTG
TGCCAGTTTTCAAAGGGAATGCTTCCAGTTTTTGCCCATTCAGTCTGATATTGGCTGTGGGTTTGTCATAGATAGCTCTTATTATTTTGA
GATATGTCCCATCAATACCTAATTCATTGAGAGTTTTTAGCATGAAGGGCTGTTGAATTTTGTCCAAGGCCTTTTCTGCATCTGTTGAGA
TAATCATGTGGTTTTTGTCTTTGGTTCTGTTTATATGCTGGATTACTTTTATTGATTTGTGTATGTTGAACCAGCCTTGCATCCCAGGGA
TGAAGCCCACTTGATCATGGTGGATAAGCTTTTTGATATGCTGCTGGATTCAGTTTGCCAGTATTTTATTGAGGATTTTTGCATTGATTT
TCATCAGGGATATTGGTCTAAAGTTCTCTTTTTTTGTTATGTCTCTGCCAGGCTTTGGTATCAGGATGATGCTGGCTTCATAAAATGAGT
TAGGGAGGATTCCCTCTTTTTCTATTGATTGGAATAGTTTCAGAAGGAATGGTACCAGCTCTTCCTTGTACCTCTGGTAGAATTCGGCTG
TGAATCCATCTTGTCCTGGACTTTTTTTGGTTGGTAGGCTATTAATTATTGCCTCAATTTCAGAGCCTGTTATTGGTCTATTCAGGGATT
AAACTTCTTCCTGGTTTAGTTTTGAGAGGGTGTATGTGTCCAGGAATTTATCTATTTCTTCTAGATTTTCTAGTTTATTTGCATAGAGGT
GTTTATAGTATTCTCTGTGTACTCTGTATTTCTGTGGGATTGGTGGTGATATCCACTTTATCATTTTTTATTGCATTTATTTGATTCTTC
TCTCTTTTCTTGTTTATTAGTCTTGCTAGCGGTCTATCAATTGTGTTTATCTTTTCAAAAAACCAGCTCCTGGATTCATTCATTTTTTGA
AGGTTTTTTTGTGTCTCTGTCTCCTTCAGTTCTGCTCTGATCTTAGTTATTTCTTGTCTTCTGCTAGCTGTTGAATGTGTTTGCTCTTGC
TTCTCTAATATTTTTAATTGTGATGTTAGAGTGTCAATTTTAGATCTTTCCTGCTTTCTCTTGTGGGCACTTAGTGCTGTAAATTTCCCT
CTACACACTGCTTTAAATGTGTCCCAGAGATTCTGGTATGTTGTGTCTTTGTTCTCGTTGGTTTCAAAGAACATCTTTATTTCTGCCTTC
ATTTTGTTATGTACCCAGTAGTCATTCAGGAGCAGGTTGTTCAGTTTCCATGTAGCTGAGTGGTTTTGAGTGAGTTTCTTAATCCTGAGT
TCTAGTTTGATTGCACTGTGGTCTGAGACAGTATGTTATAATTTCTGTTCTTTTACATTTGCTGAGGAGTGCTTTACTTCCAACTATGTG
GTCAATTTTGGAATAGGTGCGATGTGGTGCTGAGAAGAATGTATATTCTGTTGATTTGGGGTGGAGAGTTCTGTAGATGTCTATTAGGTC
TGCTTGGTGCAGAGCTGAATTCAATTCCTGGATATCCTTGTTAACTTTCTGTCTCGTTGATCTGTCTAATATTGACAGTGGGGTGTTAGA
GTCTCCCATTGTTATTGTGTGGGAGTCTAAATCTCTTTGTAGGTCTCTAAGGACTTGGTTTATGAATCTGGGTGCTCCTGTATTGGGTGC
ATATATATTTAAGATAGTTAGCTCTTCTTGTTGAATTGATCCCTTTACTATCATGTAATGGCCTTCTTTGTCTCTTTTGATCTTTGTTGG
TTTAAAGTCTGTTTTATCAGAGACTAGGATTGCAACCCCGGCCTTTTTTTTTGTTTTCCGTTTGCTTGGTAGATCTTCCTCCATCCTTTT
ATTTTGAGCCTATGTGTGTGTGTCTCTGTACGTGAGATGGGTTTCCTGAATACAGCACCCTGATGGGTCTTGACTCTTTATCCAGTGTGC
CAGTCTGTGTCTTTTAATTGGAGCATTTAGCCCATTTACATTTAAGGTTAATATTGTTATGTGTGAATTTGATCCTGTCACTAGGATGTT
CACTGGTTATTTTGCTCGTTAGTTGATGCAGTTTCTTCCTAGCCTCAATGGTCTTTACAATTTGGCATGTTTTTGCAGTGGCTGATACTG
GTTGTTCCATTCCATGTTTAGTGCTTCCTTCAGGAGCTCTTGTAAGGCAGGCCTGGTGGTGACAAAATCTCTCAGCATTTGCTTGTTTGT
AAAGGATTTTATTTCTCCTTCACTTATGAAGCTTAGTTTGGCTGGATATGAAATTCTGGGTTGAAAATTCTTTTCTTCAAGAACGTTGAA
TATTGACCCCCACTCTCTTCTGGCTTGTAGAGTTTCTGCTGAGAGATCAGCTGTTAGTCTGATGGGCTTCCCTTTGTGGGTAACCCGACC
TTTCTCTCTGGCTGCCCTTAACATTTTTTCCTTCATTTCAACTTTGGTGAATCTGACAATTATGTGTCTTGGAGTTGCTCTTCTCGAGGA
GTATCTTTGTGGCGTTCTCTGTATTTCCTGAATTTGAATGTTGTCCTCCCTTGCTAGATTGGGGAAGTTCTCCTGGATAATATCCTGCAG
AGTGTTTTCCAGCTTGGTTCCATTCTCCCCGTCACTTTCAGGTACACCAATCAGACGTAGATTTGGTCTTTTCACATAGTCCCATATTTC
TTGGAAGCTTTGTTCGTTTCTTTTTACTCTTTTTTCTCTTAACTTCTCTTCTCACTTCATTTCATTCATCTGATCTTCAATCACTGATAA
CCTTTCTTCCAGTTGATCGAATTGGCTACTGAAGCTTGTGCATTCGTCACGTAGTTCTCATGCCATGGTTTTCAGCTCCATCAGGTCATT
TAAGGACTTCTCTATGCTGGTTATTCTAGTTAGCCATTTGTCTAATCTTTTTTCAAGGTTTTTAGGTTCTTTGTGATGGGTTCGAACTTC
CTCTTTTAGCTTGGAGAAGTTTGATCATCTGAAGCCTTCTTCTCTCAACTCGTCAAAGTCATTCTCCGTCCAGCTTTGTTCTGTTGCTGG
CAAGGAGCTATGTTCCTTTGGAGGGGGAGAGGCGCTCTGATTTTTAGAATTTTCAGCTTTTCTGCTCTGTTTTTTCCCCATCTTTGTGGT
TTTATCTACCTTTGGTCTTTGGTGATGGTGATGTGCAGATGGGGTTTTGGTGTGGATGTCCTTTCTGTTTGTTAGTTTTCCTTCTAACAG
TCAGGACCGCCAGCTGCAGGTCTGTTGGAGTTTGCTGGACGTCCACGCCAGACCCTGTTTGCCTGGGTATCACAGTGGAGGCTGTAGAAC
AGCGAATATTGCTGAACAGCAAATGTTGCTGCCTGATCATTCCTCTGGAAGCTTCATCTCAGAGGGGTACCCGGCCATGTGGGGTGTCAG
TCTGCCCCTACTTGGGGGTGCCTCCCAGTTAGGCTACTCGGGGGTCAGGGACTCACTTGAGGAGGCAGTCTCTCCGTTCTCAGATCTCAA
ACTCTGTGCTGGGAGAACCACTGGTCTCTTCAAAGCTGTCAGACAGGGACATTGAAGTCTGCAGAGATTTCTGCTGCCTTTTGTTCGGCT
ATGCCATGCCCCCAGAGGTGGAGTCTACAGAGGCAGGCAGGCAGGCCTCCTTGAGCTGCAGTGGGCTCCACCTAGTTCGAGCTTCCCGGC
TGCTTTATTTACCTACTGAAGCCTCAGCAATGGTGGGCTCCCCTCCCCTAGCCTCACTGCCACCTTGCAGTTCGATCTCAGACTGCTGTG
CTAGCAATGAGCAAGGCTCCATGGGCGTGGGACCCTCCGAGCTAGGCACAGGATATAATCTCCTGGTGTGCCGTTTGCTAAGACCATTGG
AAAAACGCAGTATTAGGGTGGGAGTGACCCAATTTTCCAGGTGCCGTCTGTCACAGCTTCCCTTGGCTAGGAAAGGGAATTCCCTGACCC
CTTGCCTTCCCGGGTGAGGCCATGCCTTGCCCTGCTTCAGCTCATGCTCAGTGGGCTGCACCCACCGTCCTACACCCACTGTCCAACAAG
CCCCAGTGAGATGAACCTGGTACCTCAGTTGGAAGTGCAGAAATCACCTGTCTTCTGCGTCGCTCACGCTGGGAGCTGTAGACTGGAGCT
GTTCCTATTCGGCCATCTTGGAACCCAACCCAAGTCTGGCATTTTTTGGTTTTCTCTGTGTATTGACTATGATTATAGAGGATAAATGGA
TATTGATATTATTAAATCGTCATTTACAGAAGGCACACAACTTATATCCTTTAAACAAAGTTCTCCAACCAGTAGGGTATACTTGCTGGT
AGTGCTTACAGCTGCCACCATTCTTCACTGGGGCTCAGAGTGGATGCCTGGAGGAAAAAAACAAATGAATCTTTTAGCTCCTAGTTACTG
TTAGCATTTTTACCAGAAAACAATTTAAAAAATGACACAAGTAAGTCTTCACCTATCAAGGCTGAGTGTGGTGGCCTATACTTGTAATCT
CTGTGCTTTGGGAGGCCAACGCAGGAGGATCTCTTGAGTCCAGGAGTTTGAGACCAGCCTGGGCAACAAAGCAAGACCCCATCTCTACAG
AAAGTTAAAATTTAGCTGGGCATGCTGGCACATCCCTATAGTCCCAGCTACTTGAGAGGCTGAGTTGGGAGGATCCCTTGAGGTCATGAG
TTGGAGTCTACAGTGAGCTGTGATTACAGTGTGAGTCTACACTGCACTCCAGTCTGGGTGAAAGAGATCCTGTCTCTCAAAAAACAAGTG
ATTCTCCTGGGAAGAGATTTGTTTAAAAAGTCTGCACCTCTATTGATGATAACTTTGAATGTAAATGGATTAAATTCTCCCACTTAAAAG
ATATAGATTGACTGAATGGATTAAAAACCACCATCATGACTCGACTGTATGCTGCCTACAAGAAACCTCACCTGTAAAGACAGGCCAAAA
GTGAAGGTATGGAGAAAGATATTGCATACAAATGGAAGCCAAAAAAGAGCAGAAATAACTATACTTACATGAGATAAAATAGACTTTAAG
TCAAAAACTGTAAAAAGAAAAGTCATTATGTAATGAAACAAGGATCAATTCATGCAAGATATAATCATATTTTTTTATTAAGAAAATTTT
TTTGTAGAGATGGGGTTATGCTATGTTGCCTGGCTAGTCTCAAACTCTGGGTCTCAAAGCAGTCCTCCTGCTTTGGCCTCCTAAGGTGCT
GGGATTATAGGCATGAGCCACTGTGCCAGGCCTGAGGATATTATCATTATAAATATATATGTACCCCACACTGGATGACCCAGATATAAA
GCAAATATTATTAGATTTAAAGGGAGAAATAGACTCTAATACAATAGTAGTTGAGGACTTCACTCTACTCTCAGCATTGGACAGATTTTC
TAGACATAAAACCAATAAATATTGGATTTAAATTGCACTTTACACCAAATGGACCTGACATTTACAGAACATTCTAATAGGTGCAGAACA
CTCTAATAGCTGCAGAACACACGTTCTTTTCATCAGCACATGGAACATTCACCAGACTAGTTCTGGAACCCACTTCCTGCCTTAGTGTTC
TTTCCACCACAGTGCATGATAATTCCGACAGAACGCCTTTTATTTGTACCTTATTAGTTGTAGGGGGAAAGCTTTTTCATGTACAAAAAT

>54300_54300_2_MLLT3-SOD2_MLLT3_chr9_20620653_ENST00000380338_SOD2_chr6_160109274_ENST00000538183_length(amino acids)=211AA_BP=64
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRGDVTAQIALQPALKFNGGGHINHSIF
WTNLSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYL

--------------------------------------------------------------
>54300_54300_3_MLLT3-SOD2_MLLT3_chr9_20620653_ENST00000380338_SOD2_chr6_160109274_ENST00000546087_length(transcript)=1122nt_BP=480nt
GAGGCTCGGAGCCCGGGTGTCAGGCGCCACGGCGCATGCTCCGCAATCATCTTCTTTACCCTGGAGCTGCTGCTGCTGCTGCTGCTTTTG
CTTTTGGGGCTGAGTTTAATAAGCGAGCGAGCGAGCAAGCGAGCGCGGGGGGAAAAAGGCAGAGAATGTCCGCCATCTACCCTCCGCTCC
TGGGCGCGCTCTCATTCATAGCAGCCTCTTCATGAATTACAGCTGAGGGGGGGCGGAGGAGGGGGGGGTACCACACAACACCCCAGCAAA
CCTCCGGGCCCCCAGGCATGGCTAGCTCGTGTGCCGTGCAGGTGAAGCTGGAGCTGGGGCACCGCGCCCAGGTGAGGAAAAAACCCACCG
TGGAGGGCTTCACCCACGACTGGATGGTGTTCGTACGCGGTCCGGAGCACAGTAACATACAGCACTTTGTGGAGAAAGTCGTCTTCCACT
TGCACGAAAGCTTTCCTAGGCCAAAAAGAGGAGATGTTACAGCCCAGATAGCTCTTCAGCCTGCACTGAAGTTCAATGGTGGTGGTCATA
TCAATCATAGCATTTTCTGGACAAACCTCAGCCCTAACGGTGGTGGAGAACCCAAAGGGGAGTTGCTGGAAGCCATCAAACGTGACTTTG
GTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTTGGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAAC
GGGGACACTTACAAATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTGGGGATTGATGTGTGGG
AGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTATCTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAA
GATACATGGCTTGCAAAAAGTAAACCACGATCGTTATGCTGATCATACCCTAATGATCCCAGCAAGATAATGTCCTGTCTTCTAAGATGT
GCATCAAGCCTGGTACATACTGAAAACCCTATAAGGTCCTGGATAATTTTTGTTTGATTATTCATTGAAGAAACATTTATTTTCCAATTG

>54300_54300_3_MLLT3-SOD2_MLLT3_chr9_20620653_ENST00000380338_SOD2_chr6_160109274_ENST00000546087_length(amino acids)=211AA_BP=64
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRGDVTAQIALQPALKFNGGGHINHSIF
WTNLSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYL

--------------------------------------------------------------
>54300_54300_4_MLLT3-SOD2_MLLT3_chr9_20620653_ENST00000429426_SOD2_chr6_160109274_ENST00000367055_length(transcript)=979nt_BP=282nt
ATATTTCAGCCGCCGCCGCCGGGAGCTGCGGGCACAGTCCGGGGACGCGGCGAGCAGCCTCGGCGGCCGCACCTCCGCAAAGCGCCGCGG
CCGCTACGATGTGTGCCGTGCAGGTGAAGCTGGAGCTGGGGCACCGCGCCCAGGTGAGGAAAAAACCCACCGTGGAGGGCTTCACCCACG
ACTGGATGGTGTTCGTACGCGGTCCGGAGCACAGTAACATACAGCACTTTGTGGAGAAAGTCGTCTTCCACTTGCACGAAAGCTTTCCTA
GGCCAAAAAGAGGAGATGTTACAGCCCAGATAGCTCTTCAGCCTGCACTGAAGTTCAATGGTGGTGGTCATATCAATCATAGCATTTTCT
GGACAAACCTCAGCCCTAACGGTGGTGGAGAACCCAAAGGGGAGTTGCTGGAAGCCATCAAACGTGACTTTGGTTCCTTTGACAAGTTTA
AGGAGAAGCTGACGGCTGCATCTGTTGGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACAAATTG
CTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTGGGGATTGATGTGTGGGAGCACGCTTACTACCTTC
AGTATAAAAATGTCAGGCCTGATTATCTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTGCAAAA
AGTAAACCACGATCGTTATGCTGATCATACCCTAATGATCCCAGCAAGATAATGTCCTGTCTTCTAAGATGTGCATCAAGCCTGGTACAT
ACTGAAAACCCTATAAGGTCCTGGATAATTTTTGTTTGATTATTCATTGAAGAAACATTTATTTTCCAATTGTGTGAAGTTTTTGACTGT

>54300_54300_4_MLLT3-SOD2_MLLT3_chr9_20620653_ENST00000429426_SOD2_chr6_160109274_ENST00000367055_length(amino acids)=208AA_BP=61
MCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRGDVTAQIALQPALKFNGGGHINHSIFWTN
LSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYK

--------------------------------------------------------------
>54300_54300_5_MLLT3-SOD2_MLLT3_chr9_20620653_ENST00000429426_SOD2_chr6_160109274_ENST00000538183_length(transcript)=14161nt_BP=282nt
ATATTTCAGCCGCCGCCGCCGGGAGCTGCGGGCACAGTCCGGGGACGCGGCGAGCAGCCTCGGCGGCCGCACCTCCGCAAAGCGCCGCGG
CCGCTACGATGTGTGCCGTGCAGGTGAAGCTGGAGCTGGGGCACCGCGCCCAGGTGAGGAAAAAACCCACCGTGGAGGGCTTCACCCACG
ACTGGATGGTGTTCGTACGCGGTCCGGAGCACAGTAACATACAGCACTTTGTGGAGAAAGTCGTCTTCCACTTGCACGAAAGCTTTCCTA
GGCCAAAAAGAGGAGATGTTACAGCCCAGATAGCTCTTCAGCCTGCACTGAAGTTCAATGGTGGTGGTCATATCAATCATAGCATTTTCT
GGACAAACCTCAGCCCTAACGGTGGTGGAGAACCCAAAGGGGAGTTGCTGGAAGCCATCAAACGTGACTTTGGTTCCTTTGACAAGTTTA
AGGAGAAGCTGACGGCTGCATCTGTTGGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACAAATTG
CTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTGGGGATTGATGTGTGGGAGCACGCTTACTACCTTC
AGTATAAAAATGTCAGGCCTGATTATCTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTGCAAAA
AGTAAACCACGATCGTTATGCTGAGTATGTTAAGCTCTTTATGACTGTTTTTGTAGTGGTATAGAGTACTGCAGAATACAGTAAGCTGCT
CTATTGTAGCATTTCTTGATGTTGCTTAGTCACTTATTTCATAAACAACTTAATGTTCTGAATAATTTCTTACTAAACATTTTGTTATTG
GGCAAGTGATTGAAAATAGTAAATGCTTTGTGTGATTGAATCTGATTGGACATTTTCTTCAGAGAGCTAAATTACAATTGTCATTTATAA
AACCATCAAAAATATTCCATCCATATACTTTGGGGACTTGTAGGGATGCCTTTCTAGTCCTATTCTATTGCAGTTATAGAAAATCTAGTC
TTTTGCCCCAGTTACTTAAAAATAAAATATTAACACTTTCCCAAGGGAAACACTCGGCTTTCTATAGAAAATTGCACTTTTTGTCGAGTA
ATCCTCTGCAGTGATACTTCTGGTAGATGTCACCCAGTGGTTTTTGTTAGGTCAAATGTTCCTGTATAGTTTTTGCAAATAGAGCTGTAT
ACTGTTTAAATGTAGCAGGTGAACTGAACTGGGGTTTGCTCACCTGCACAGTAAAGGCAAACTTCAACAGCAAAACTGCAAAAAGGTGGT
TTTTGCAGTAGGAGAAAGGAGGATGTTTATTTGCAGGGCGCCAAGCAAGGAGAATTGGGCAGCTCATGCTTGAGACCCAATCTCCATGAT
GACCTACAAGCTAGAGTATTTAAAGGCAGTGGTAAATTTCAGGAAAGCAGAAGTTAAAGGCAAAATTGTAAATCAGTCGAGATCGGGTGC
CTTCAGGGTGGTATGGCTGTATACCAAAATTGTAAATCACTACATGAAGCTTATATATTGGTTTGGCCTGAAAGGTGAAGTGGGGTAGGC
AGGGGGCGGGCTTACAGGTTATGGTGGATTCAAAGACTCCCTGATTTGTGATTGGTTAAGGAAGCAAAGCTTTGTCTAAAAACTTGGGGT
CCGCAGAAAGGAACATTAAGGTCTGGCCAGGCCCCTCAGGAAGAAACTGAGAGCAAAGAATGGAGGTCAGAGTTTAGTCCCTGGTGTTCC
CCCTTATCTGACGTCTGTGTGAATCCATTTGGTGGGGGTCTGGGTTTCTGAAAAGTAGCTCAGGGGCACGTGTTAAGGATGTCTCTAGGT
GACTCTAACTTCCCTGGCTATTGTTTGAAACTGTTATGACCTTCTTGCTTATCAGCTTGCTGGTTTCCTTCTCGGGGCGAGCTGGGTGCC
TGGAGTTTTCGGTGAAGGAAACTCAAGATTCTCCTTTATTTCTGTGCTTGTGGGAATCCCCCTGGCACACCCCAAAGAGGGGTCCCTGCT
CCGTCTCACAGGGATCTTTTTGTATATTTGGCTTAGCATCATACATTTGCCATGTTGTTTCATCATCTGCCTAATTTACTGTTTTTGAAT
ATTTCATTTGTTTCTAATTGTTACTACAGATAATGCTGGGGTGAGCAACTCTGTGTACATAGGTTTATCTCCTATTGGAATATTTTCTTT
ATATAGGCGTTTTTTTTTTTTCTTTTTTTTTGGAGACAGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGACCGGAGCTCAC
TGCAACCTCCACTTCCCGGGTTCAAGTGATTGTCCCACCTCAGCCTCCTGAATAGCTGGGATTACAGGTGCATGCTACCATGCCTGGCTA
CTTTTTGTATTTTTAGCAGAGACAGGGTTTCACCATGTTGGCCAGGGTGGTCTCGAACTCCTGACCTCAAGTGATCCGTCTGGCTCAGCC
TCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCTGGCCTATATAGGCTTTTTTCTTAAACCTATTTAGTAATGTTTTCCCAAGT
TTATTTTTTATTTTTAATTTTTTCCCCAAGTTTATTTTTCTATTTTTTTTTCATGGAAAAATGGGGTAACTTAGCAGTTTCAATATTGAA
GACTGAAGTTTAAAAAAAATTTAAATTCAAGGTACTTTTAAAATTCAGTTAGAAAAGTAGGCTTTAAAAATTATTAGAGACAAGAGTACC
AAAGCGGTGTGTGTATGTGTGTGTGTGTATGCATGCTTGTGGATTGGAAAAACTTTGGAGACTGATTACTTTTCATTATATATGTGTCAC
AGTGAAACAGCTTTTATGTGTCATGTAAGATTACTGCTTGCCTCTCTAAGGAAGGTCGTGACTGTTTAAATAGACGGGCAAGGTGGAACC
TTTTGAAAGATGAGCTTTTGAATATAAGTTGTCTGCTAGATCATGGTTTGTATTGAACTAACAAGGTTTGCAGATCTGCTGACTTATATA
AAGCTTTTTGATTCCTACTAAGCTTTAAGATTTAAAAAATGTTCAATGTTGAAATTTCTGTGGGGCTCTATTTTTGCTTTGGCTTTCTGG
TGAGAGAGTGAGGAAGCATTCTTTCCTTCACTAAGTTTGTCTTTCTTGTCTTCTGGATAGATTGATTTTAAGAGACTAAGGGAATTTACA
AACTAAAGATTTTAGTCATCTGGTGGAAAAGGAGACTTTAAGATTGTTTAGGGCTGGGCGGGGTGACTCACATCTGTAATCCCAGCACTT
TGGGAGGCCAAGGCAGGCAGAACACTTGAAGGAGTTCAAGACCAGCGTGGCCAACGTGGTGAAACCCTGTCTCTACTAAAAATACAAAAA
TTGTTTAGCTCTGTTTTTCATAATAGAAATAGAAAAGGTAAAATTGCTTTTCTTCTGAAAAGAACAAGTATTGTTCATCCAAGAAGGGTT
TTTGTGACTGAATCAGCAGTGCCTGCCCTAGTCATAGCTGTGCTTCAAAAACCTCAGCATGATTAGTGTTGGAGCAAAACAAGGAAGCAA
AGCAAATACTGTTTTTGAAATTCTATCTGTTGCTTGAACTATTTTGTAATAATTAAACTTTGATGTTGAGAAATCACAACTTTATTGTAC
ACTTCATTGCAACTTGAAATTCATGGTCTTAAAGTGAGATTTGAATTTCTATTGAGCGCCTTTAAAAAAGTAATACCAAACCATAAAGTT
AAAATCTATGTATATTGAGTCATATCTAAAACCACGTATAAACATAAATTGTATTTCCTGTTTTAATTCCAGGGGAAGTACTGTTTGGGA
AAGCTATTATTAGGTAAATGTTTTACAAATTACTGTTTCTCACTTTCAGTCATACCCTAATGATCCCAGCAAGATAATGTCCTGTCTTCT
AAGATGTGCATCAAGCCTGGTACATACTGAAAACCCTATAAGGTCCTGGATAATTTTTGTTTGATTATTCATTGAAGAAACATTTATTTT
CCAATTGTGTGAAGTTTTTGACTGTTAATAAAAGAATCTGTCAACCATCAAAGAGGTCTGCATTATGCTTGCATGTCAAAAACTTTAAAA
ATCCTATAATCTTCTGTCATTTTCACTGAGTTTCCATGGGAAAGGAATAGTAAATAATGGGTAGTTGAAATATTACTCTTAAGACCAAGA
CCTGTATCTCCAGTCATATCTGTAATAACATCATCTGATAACCTAAAAGCATAGTATTAGGGATATACGACAAAACCAAAGTGTTTTTGC
TGTTGTCACATACCACTCAATACTTTTACACCAGGTTGTCCAGTGGACACCAGCTGGATGTCCTATAATTCAATTCTGACACTGTCTACC
TGGAATTGGAGTCAGATCCCACAGGTGGAGGGCTCAGCCCACAAGACTGCCCCCACTCCAGATACCAATCGCAAGTCCCTATACTTCTGA
CTGGCTATAAAGTGGGGTTCCCGTGACCCTTTCCTTGGTTTTGATTTATTTGCTAGAGCAGCTCCCAGAACACAGAGAAACACTCTACTT
ATGTTTACCCATTTTTAATTTTATTACTTTATTAAAACTACATATTGGTTACAATACTAATTTATTGTAAAGGATATTTCATTTATTTAT
TTTTTTATTTAGAGATGGAGTCTCACTGTGTCACCCAGGCTGGAGTGCGGTGGCACAGTCTCAACTCACTGCAACCTCCACCTCCTGAGT
TCAAGCGATTCTCATGCCTCAGCCTCCCAAGTAGCTGGGATTACAAGTGTGCACCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAG
ATGGGGTTTCACTCTGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTCATCCACCCACCTCAGCCTCCCAAAGTGCTGAGATTACA
GGTGTGAGCCATTGCCTCTGGCTTGTAAAGGATATTTCAAAGAATACAGATGAACAGCCAGATGGAAGAGATGCACAGGGCAAGGCATGT
GGGAAGGGGTATGGAGCTTTCATGCTCTCTCCACGTCATCAGCTACCCAGAAGCTCATCTGGACCCCGACCCTTTGGGGTTTTACGGAGG
CTTCATTATGTCAGCATTACCATTGGCAATTGGCGATTAACTCAACCTTCAGCCTCTCTCCCCTTTCTGGAGGTTGGGGGTTGAGGCTGG
GAGTCCAAACCCTCCAATCTTGCCTTGGTCTTTCTGGTAAGCAGCCCCCCGTCCTGAAGCTACCTAGAGGCTCCCAGCCACCAATCATTT
CATTGGCAAACCAAAGATACTTCAAGGGGTTTAGGAGCCAAGAGACCAAGCAAGGATTGAGACAATATATATATTTCTTATAAATAACAT
GATCACAAATAGTATTTTATATATTTCTCATAATAGCTGGTTGTGGTTACTCACACCTATCATCCCAGCTACTAAGAAGCTAAGGCAGGA
GGATCACAGGCCCAGGAGTTTGCAGCTGTAGTGAGCTATGATTGTGCTACTGCACTCCAGCCTGGGTGACAGTGTGAGACCCTGTCTCTT
AAAGTTCTTGTAACATCTTAGAACATTAACCAACCACAGATTATTGCCTTAACTCTGAAAAATAAAGTAATCATACTTTTACAAGATGTA
TTTTACATAAAGTTCTGGTGATATTTTACTCTGGTCATTGGAATATAGGAGCTTACCACCTGGTACCACTCTTCCTAAAGTGGTATACTA
TTTGGTATAGTACTGGCATACTATTTGGAAAGGGATGTGAAGTTGGCATGACCTGTCTAGGGTGAAGTCATGCTGTCTGCTATTCATTGT
GGGCTTTACAGTAATGAGAGTGCTTCTGTTGTCAAGATGCTTCTGGGACACGTTAAAAAAAATTTAAGATTTCTCAGTTTGTGAAAAGGA
AGGAGCACGAATGCTTTCAAGTTCCTATGACATGCTAGTCATCTTTCAGTGTGTCCCATTGTTGCACCCAGTAGTCTCGATGCCCAGCGT
CACGGTGATTCCAAGTTTGCCTCTCTGCCCACTATAATTTGTGCTCCATGAAGTCCCAGGACATGAGGTTCTTGTTCATTTGTGCGTCTG
GGCCCATATCCAAATATTAAACAATGTGACTTAATGTATTTATCATATTGTAAATATGGGTATCCCCAAGGCTCAGAAGTTAACACAGCA
TATCCACAGAGAGGTTTGACAGCATGGCTGTGGTGACTGGGAAGGCCTTATGCTTGCTCCTCCTTCTGCTGCTTGCCTTTGTGTGGGCAT
GGAAAGAACATTGAATTAGGTACTGGAAGACCTGGGTCCTGGTCTTGGAGATTTTACCAGAGCACCTGTGGGATATTGGTCAAGATGCCT
GGTTTTAGTCCTGCTCCTTTGCTGTGAAAGAGGATCTTAAGGTGCCAACTCTGGCATTTTATTTTTTACTTATTTATTTTTAAATTATAC
TTTAAGTTCTAGGGTACATGTGTACAACATGCAGGTTTGTTACATGTATACATGTGCCATGTTGGTGTGCTGCACCTATTAACTCGTCAT
TTACATTAGGTATATCTCCTAATGCTATCCCTCCCCCTTCTCCCCACCCCTCGACAGGCCCCGGTGTGTGATGTTCCCCTTCCTGTGTCC
AAGTGTTCTCATTGTTCAATTCCCATCTATGAGTGAGAACATGCGGTGTTTGTTTTTTTGTCCTTGGAATAGTTTGCTGAGAAGGATGGT
TTCCAGCTTCATCCATGTCCCTATAAAGGACATGAACTCTTCCTTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTGCCACATCTT
CTTAAACCAATCTATCATTGATGGACATTTGGGTTGGTTCCAAGTCTTTGCTATTGTGAACAGTGCCACAATAAATATACGTGTGCATGT
GTCTTTATAGCAGCATGATTTATAATCCTTTGGGTATATACCCAGTAATGGGATGGCTGGGTCAAATGGTATTTCTAGTTCTAGATCCCT
GAGGAATCGCCACACTGTCTTCCACAATGGTTGAACTAGTTTACAGTCCCACCACCAGTGTAAAAGTGTTCCTATTTCTCCACATCCTCT
CCAGCACCTGTTGTTTCCTGACTTTTTAATGATTGACATTCTAACTGGTGTGAGATGGTATCTCATTGTGGTTTTGATTTGCATTTCTCT
GATGGCCCATGATGATGAGCATTTTTTTCATGTGTCTGTTGGATGCATGGATGTCTTCTTTTGAGAAGTGTCTCTTCATATCCTTCACCT
ACTTTTTGATGGGGTTTGTTTTTTTCTTGTAAGTTTGTTTGAGTTCCTTGTAGATTCTGGATATTAGCCCTTTGTCAGATGAGTAGATTG
CAAAAATTTTCTCCCATTTTGTAGGTTGCCTGTTCACTCTGATGGTAGTTTCTTTTGCTGTGCAGAAGCTCTTGAGTTTAATGAGATCCC
ATTTGTCAATTTTGGCTTCTGTTGCCATTGCTTTTGGTGTTTTAGACATGAAGTCCTTGCCCATGCCTGTGTCCTGAATGGTACTGCATA
GGTTTTCTTCTAGGGTTTTTATGGTTTTAGGTCTAACATTTAAGTCTTTAATCCATCTTGAATTAATTTTTGTATAAGGTGTAAGGAAGG
GATCCAGTTTCAGCTTTCTACATGTGGCTAGCCAGTTTTCCCAGCACCATTTATTAAATAGGGAATCCTTTCCCCATTTCTTGTTTTTGT
CAGGTTTCTCAAAGATCAGATAGTTGTAGATGTGTGGTATTATTTCTGAGGGCTCTGTTCTGTTCCATTGGTCTATATCTCTGTTTTGGT
ACTAGTACCATGCTGTTTTGGTTACTGCAGCCTTGTAGTATAGTTTGAAATCAGGTAGCGTGATGCCTCCAGCTTTGTTCTTTTGGCTTA
GGATCGTTTTGGCAGTGCAGGCTCTTTTTTGGTTCCACATGAACTTTAAAGTAGTTTTTTCCAATTCTATGAAGAAAGTCATGGGTAGCT
TGATGGGGATGGCATTGAATCTATAAATTACCTTGGGCAGTATAGCCATTTTCACGATATTGATTCTTCCTATCCATGAGCATGGAATGT
TCTTCCATTTGTTTGTGTCCTCTTTTATTTCCTTGAGCAGTGGTTTGTAGTTCTCCTTGAAGAGGTCCTTCACATCCCTTGTAAGTTGGA
TTCCTAGGTATTTTATTCTCTTTGAGGCAGTTGTGAATGGGAGTTCACTCATGATTTGGCTCTCTGTTTGTCTGTTGTTGGTGTATAAGA
ATGCTTGTGATTTTTGCACATTGATTTTGTATCCTGAGATTTTGCTGAAGTTGCTTATCAAATTAAGGAGATTTTGGGCTGAGATGATGG
GGTTTTCTAAATATAAAATCATGTCATCTGCAAACAGGGACAATTTGACTTCCTCTTTTCCTTATTGAATACCCTTTATTTCTTTCTCCT
GCCTGATGGCCCTGGCCAGAACTTCCAACACTATGTTGAATAGGAGTGGTGAGAGAGGGCATCCCTGTCTTGTGCCAGTTTTCAAAGGGA
ATGCTTCCAGTTTTTGCCCATTCAGTCTGATATTGGCTGTGGGTTTGTCATAGATAGCTCTTATTATTTTGAGATATGTCCCATCAATAC
CTAATTCATTGAGAGTTTTTAGCATGAAGGGCTGTTGAATTTTGTCCAAGGCCTTTTCTGCATCTGTTGAGATAATCATGTGGTTTTTGT
CTTTGGTTCTGTTTATATGCTGGATTACTTTTATTGATTTGTGTATGTTGAACCAGCCTTGCATCCCAGGGATGAAGCCCACTTGATCAT
GGTGGATAAGCTTTTTGATATGCTGCTGGATTCAGTTTGCCAGTATTTTATTGAGGATTTTTGCATTGATTTTCATCAGGGATATTGGTC
TAAAGTTCTCTTTTTTTGTTATGTCTCTGCCAGGCTTTGGTATCAGGATGATGCTGGCTTCATAAAATGAGTTAGGGAGGATTCCCTCTT
TTTCTATTGATTGGAATAGTTTCAGAAGGAATGGTACCAGCTCTTCCTTGTACCTCTGGTAGAATTCGGCTGTGAATCCATCTTGTCCTG
GACTTTTTTTGGTTGGTAGGCTATTAATTATTGCCTCAATTTCAGAGCCTGTTATTGGTCTATTCAGGGATTAAACTTCTTCCTGGTTTA
GTTTTGAGAGGGTGTATGTGTCCAGGAATTTATCTATTTCTTCTAGATTTTCTAGTTTATTTGCATAGAGGTGTTTATAGTATTCTCTGT
GTACTCTGTATTTCTGTGGGATTGGTGGTGATATCCACTTTATCATTTTTTATTGCATTTATTTGATTCTTCTCTCTTTTCTTGTTTATT
AGTCTTGCTAGCGGTCTATCAATTGTGTTTATCTTTTCAAAAAACCAGCTCCTGGATTCATTCATTTTTTGAAGGTTTTTTTGTGTCTCT
GTCTCCTTCAGTTCTGCTCTGATCTTAGTTATTTCTTGTCTTCTGCTAGCTGTTGAATGTGTTTGCTCTTGCTTCTCTAATATTTTTAAT
TGTGATGTTAGAGTGTCAATTTTAGATCTTTCCTGCTTTCTCTTGTGGGCACTTAGTGCTGTAAATTTCCCTCTACACACTGCTTTAAAT
GTGTCCCAGAGATTCTGGTATGTTGTGTCTTTGTTCTCGTTGGTTTCAAAGAACATCTTTATTTCTGCCTTCATTTTGTTATGTACCCAG
TAGTCATTCAGGAGCAGGTTGTTCAGTTTCCATGTAGCTGAGTGGTTTTGAGTGAGTTTCTTAATCCTGAGTTCTAGTTTGATTGCACTG
TGGTCTGAGACAGTATGTTATAATTTCTGTTCTTTTACATTTGCTGAGGAGTGCTTTACTTCCAACTATGTGGTCAATTTTGGAATAGGT
GCGATGTGGTGCTGAGAAGAATGTATATTCTGTTGATTTGGGGTGGAGAGTTCTGTAGATGTCTATTAGGTCTGCTTGGTGCAGAGCTGA
ATTCAATTCCTGGATATCCTTGTTAACTTTCTGTCTCGTTGATCTGTCTAATATTGACAGTGGGGTGTTAGAGTCTCCCATTGTTATTGT
GTGGGAGTCTAAATCTCTTTGTAGGTCTCTAAGGACTTGGTTTATGAATCTGGGTGCTCCTGTATTGGGTGCATATATATTTAAGATAGT
TAGCTCTTCTTGTTGAATTGATCCCTTTACTATCATGTAATGGCCTTCTTTGTCTCTTTTGATCTTTGTTGGTTTAAAGTCTGTTTTATC
AGAGACTAGGATTGCAACCCCGGCCTTTTTTTTTGTTTTCCGTTTGCTTGGTAGATCTTCCTCCATCCTTTTATTTTGAGCCTATGTGTG
TGTGTCTCTGTACGTGAGATGGGTTTCCTGAATACAGCACCCTGATGGGTCTTGACTCTTTATCCAGTGTGCCAGTCTGTGTCTTTTAAT
TGGAGCATTTAGCCCATTTACATTTAAGGTTAATATTGTTATGTGTGAATTTGATCCTGTCACTAGGATGTTCACTGGTTATTTTGCTCG
TTAGTTGATGCAGTTTCTTCCTAGCCTCAATGGTCTTTACAATTTGGCATGTTTTTGCAGTGGCTGATACTGGTTGTTCCATTCCATGTT
TAGTGCTTCCTTCAGGAGCTCTTGTAAGGCAGGCCTGGTGGTGACAAAATCTCTCAGCATTTGCTTGTTTGTAAAGGATTTTATTTCTCC
TTCACTTATGAAGCTTAGTTTGGCTGGATATGAAATTCTGGGTTGAAAATTCTTTTCTTCAAGAACGTTGAATATTGACCCCCACTCTCT
TCTGGCTTGTAGAGTTTCTGCTGAGAGATCAGCTGTTAGTCTGATGGGCTTCCCTTTGTGGGTAACCCGACCTTTCTCTCTGGCTGCCCT
TAACATTTTTTCCTTCATTTCAACTTTGGTGAATCTGACAATTATGTGTCTTGGAGTTGCTCTTCTCGAGGAGTATCTTTGTGGCGTTCT
CTGTATTTCCTGAATTTGAATGTTGTCCTCCCTTGCTAGATTGGGGAAGTTCTCCTGGATAATATCCTGCAGAGTGTTTTCCAGCTTGGT
TCCATTCTCCCCGTCACTTTCAGGTACACCAATCAGACGTAGATTTGGTCTTTTCACATAGTCCCATATTTCTTGGAAGCTTTGTTCGTT
TCTTTTTACTCTTTTTTCTCTTAACTTCTCTTCTCACTTCATTTCATTCATCTGATCTTCAATCACTGATAACCTTTCTTCCAGTTGATC
GAATTGGCTACTGAAGCTTGTGCATTCGTCACGTAGTTCTCATGCCATGGTTTTCAGCTCCATCAGGTCATTTAAGGACTTCTCTATGCT
GGTTATTCTAGTTAGCCATTTGTCTAATCTTTTTTCAAGGTTTTTAGGTTCTTTGTGATGGGTTCGAACTTCCTCTTTTAGCTTGGAGAA
GTTTGATCATCTGAAGCCTTCTTCTCTCAACTCGTCAAAGTCATTCTCCGTCCAGCTTTGTTCTGTTGCTGGCAAGGAGCTATGTTCCTT
TGGAGGGGGAGAGGCGCTCTGATTTTTAGAATTTTCAGCTTTTCTGCTCTGTTTTTTCCCCATCTTTGTGGTTTTATCTACCTTTGGTCT
TTGGTGATGGTGATGTGCAGATGGGGTTTTGGTGTGGATGTCCTTTCTGTTTGTTAGTTTTCCTTCTAACAGTCAGGACCGCCAGCTGCA
GGTCTGTTGGAGTTTGCTGGACGTCCACGCCAGACCCTGTTTGCCTGGGTATCACAGTGGAGGCTGTAGAACAGCGAATATTGCTGAACA
GCAAATGTTGCTGCCTGATCATTCCTCTGGAAGCTTCATCTCAGAGGGGTACCCGGCCATGTGGGGTGTCAGTCTGCCCCTACTTGGGGG
TGCCTCCCAGTTAGGCTACTCGGGGGTCAGGGACTCACTTGAGGAGGCAGTCTCTCCGTTCTCAGATCTCAAACTCTGTGCTGGGAGAAC
CACTGGTCTCTTCAAAGCTGTCAGACAGGGACATTGAAGTCTGCAGAGATTTCTGCTGCCTTTTGTTCGGCTATGCCATGCCCCCAGAGG
TGGAGTCTACAGAGGCAGGCAGGCAGGCCTCCTTGAGCTGCAGTGGGCTCCACCTAGTTCGAGCTTCCCGGCTGCTTTATTTACCTACTG
AAGCCTCAGCAATGGTGGGCTCCCCTCCCCTAGCCTCACTGCCACCTTGCAGTTCGATCTCAGACTGCTGTGCTAGCAATGAGCAAGGCT
CCATGGGCGTGGGACCCTCCGAGCTAGGCACAGGATATAATCTCCTGGTGTGCCGTTTGCTAAGACCATTGGAAAAACGCAGTATTAGGG
TGGGAGTGACCCAATTTTCCAGGTGCCGTCTGTCACAGCTTCCCTTGGCTAGGAAAGGGAATTCCCTGACCCCTTGCCTTCCCGGGTGAG
GCCATGCCTTGCCCTGCTTCAGCTCATGCTCAGTGGGCTGCACCCACCGTCCTACACCCACTGTCCAACAAGCCCCAGTGAGATGAACCT
GGTACCTCAGTTGGAAGTGCAGAAATCACCTGTCTTCTGCGTCGCTCACGCTGGGAGCTGTAGACTGGAGCTGTTCCTATTCGGCCATCT
TGGAACCCAACCCAAGTCTGGCATTTTTTGGTTTTCTCTGTGTATTGACTATGATTATAGAGGATAAATGGATATTGATATTATTAAATC
GTCATTTACAGAAGGCACACAACTTATATCCTTTAAACAAAGTTCTCCAACCAGTAGGGTATACTTGCTGGTAGTGCTTACAGCTGCCAC
CATTCTTCACTGGGGCTCAGAGTGGATGCCTGGAGGAAAAAAACAAATGAATCTTTTAGCTCCTAGTTACTGTTAGCATTTTTACCAGAA
AACAATTTAAAAAATGACACAAGTAAGTCTTCACCTATCAAGGCTGAGTGTGGTGGCCTATACTTGTAATCTCTGTGCTTTGGGAGGCCA
ACGCAGGAGGATCTCTTGAGTCCAGGAGTTTGAGACCAGCCTGGGCAACAAAGCAAGACCCCATCTCTACAGAAAGTTAAAATTTAGCTG
GGCATGCTGGCACATCCCTATAGTCCCAGCTACTTGAGAGGCTGAGTTGGGAGGATCCCTTGAGGTCATGAGTTGGAGTCTACAGTGAGC
TGTGATTACAGTGTGAGTCTACACTGCACTCCAGTCTGGGTGAAAGAGATCCTGTCTCTCAAAAAACAAGTGATTCTCCTGGGAAGAGAT
TTGTTTAAAAAGTCTGCACCTCTATTGATGATAACTTTGAATGTAAATGGATTAAATTCTCCCACTTAAAAGATATAGATTGACTGAATG
GATTAAAAACCACCATCATGACTCGACTGTATGCTGCCTACAAGAAACCTCACCTGTAAAGACAGGCCAAAAGTGAAGGTATGGAGAAAG
ATATTGCATACAAATGGAAGCCAAAAAAGAGCAGAAATAACTATACTTACATGAGATAAAATAGACTTTAAGTCAAAAACTGTAAAAAGA
AAAGTCATTATGTAATGAAACAAGGATCAATTCATGCAAGATATAATCATATTTTTTTATTAAGAAAATTTTTTTGTAGAGATGGGGTTA
TGCTATGTTGCCTGGCTAGTCTCAAACTCTGGGTCTCAAAGCAGTCCTCCTGCTTTGGCCTCCTAAGGTGCTGGGATTATAGGCATGAGC
CACTGTGCCAGGCCTGAGGATATTATCATTATAAATATATATGTACCCCACACTGGATGACCCAGATATAAAGCAAATATTATTAGATTT
AAAGGGAGAAATAGACTCTAATACAATAGTAGTTGAGGACTTCACTCTACTCTCAGCATTGGACAGATTTTCTAGACATAAAACCAATAA
ATATTGGATTTAAATTGCACTTTACACCAAATGGACCTGACATTTACAGAACATTCTAATAGGTGCAGAACACTCTAATAGCTGCAGAAC
ACACGTTCTTTTCATCAGCACATGGAACATTCACCAGACTAGTTCTGGAACCCACTTCCTGCCTTAGTGTTCTTTCCACCACAGTGCATG
ATAATTCCGACAGAACGCCTTTTATTTGTACCTTATTAGTTGTAGGGGGAAAGCTTTTTCATGTACAAAAATGCTGTAATTTTCTGATTT

>54300_54300_5_MLLT3-SOD2_MLLT3_chr9_20620653_ENST00000429426_SOD2_chr6_160109274_ENST00000538183_length(amino acids)=208AA_BP=61
MCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRGDVTAQIALQPALKFNGGGHINHSIFWTN
LSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYK

--------------------------------------------------------------
>54300_54300_6_MLLT3-SOD2_MLLT3_chr9_20620653_ENST00000429426_SOD2_chr6_160109274_ENST00000546087_length(transcript)=924nt_BP=282nt
ATATTTCAGCCGCCGCCGCCGGGAGCTGCGGGCACAGTCCGGGGACGCGGCGAGCAGCCTCGGCGGCCGCACCTCCGCAAAGCGCCGCGG
CCGCTACGATGTGTGCCGTGCAGGTGAAGCTGGAGCTGGGGCACCGCGCCCAGGTGAGGAAAAAACCCACCGTGGAGGGCTTCACCCACG
ACTGGATGGTGTTCGTACGCGGTCCGGAGCACAGTAACATACAGCACTTTGTGGAGAAAGTCGTCTTCCACTTGCACGAAAGCTTTCCTA
GGCCAAAAAGAGGAGATGTTACAGCCCAGATAGCTCTTCAGCCTGCACTGAAGTTCAATGGTGGTGGTCATATCAATCATAGCATTTTCT
GGACAAACCTCAGCCCTAACGGTGGTGGAGAACCCAAAGGGGAGTTGCTGGAAGCCATCAAACGTGACTTTGGTTCCTTTGACAAGTTTA
AGGAGAAGCTGACGGCTGCATCTGTTGGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACAAATTG
CTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTGGGGATTGATGTGTGGGAGCACGCTTACTACCTTC
AGTATAAAAATGTCAGGCCTGATTATCTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTGCAAAA
AGTAAACCACGATCGTTATGCTGATCATACCCTAATGATCCCAGCAAGATAATGTCCTGTCTTCTAAGATGTGCATCAAGCCTGGTACAT
ACTGAAAACCCTATAAGGTCCTGGATAATTTTTGTTTGATTATTCATTGAAGAAACATTTATTTTCCAATTGTGTGAAGTTTTTGACTGT

>54300_54300_6_MLLT3-SOD2_MLLT3_chr9_20620653_ENST00000429426_SOD2_chr6_160109274_ENST00000546087_length(amino acids)=208AA_BP=61
MCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRGDVTAQIALQPALKFNGGGHINHSIFWTN
LSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MLLT3-SOD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MLLT3-SOD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MLLT3-SOD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource