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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MLPH-SHARPIN (FusionGDB2 ID:54339)

Fusion Gene Summary for MLPH-SHARPIN

Fusion gene summary

Fusion gene information	Fusion gene name: MLPH-SHARPIN
	Fusion gene ID: 54339
		Hgene	Tgene
	Gene symbol	MLPH	SHARPIN
	Gene ID	79083	81858
	Gene name	melanophilin	SHANK associated RH domain interactor
	Synonyms	SLAC2-A	SIPL1
	Cytomap	2q37.3	8q24.3
	Type of gene	protein-coding	protein-coding
	Description	melanophilinexophilin-3slp homolog lacking C2 domains asynaptotagmin-like protein 2a	sharpinhSIPL1shank-associated RH domain-interacting proteinshank-interacting protein-like 1
	Modification date	20200320	20200313
	UniProtAcc	Q9BV36	SHARPIN
	Ensembl transtripts involved in fusion gene	ENST00000468178, ENST00000264605, ENST00000338530, ENST00000409373, ENST00000410032, ENST00000445024,	ENST00000398712, ENST00000533948,
Fusion gene scores	* DoF score	7 X 6 X 4=168	7 X 2 X 4=56
	# samples	7	7
	** MAII score	log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/56*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: MLPH [Title/Abstract] AND SHARPIN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MLPH(238419744)-SHARPIN(145154972), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SHARPIN	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	21455173
Tgene	SHARPIN	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	21455173
Tgene	SHARPIN	GO:0097039	protein linear polyubiquitination	21455173\|21455180\|21455181
Tgene	SHARPIN	GO:2000348	regulation of CD40 signaling pathway	21455173

Fusion gene breakpoints across MLPH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SHARPIN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-IN-7808-01A	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-

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Fusion Gene ORF analysis for MLPH-SHARPIN

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000468178	ENST00000398712	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-
3UTR-5UTR	ENST00000468178	ENST00000533948	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-
5CDS-5UTR	ENST00000264605	ENST00000533948	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-
5CDS-5UTR	ENST00000338530	ENST00000533948	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-
5CDS-5UTR	ENST00000409373	ENST00000533948	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-
5CDS-5UTR	ENST00000410032	ENST00000533948	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-
5CDS-5UTR	ENST00000445024	ENST00000533948	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-
In-frame	ENST00000264605	ENST00000398712	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-
In-frame	ENST00000338530	ENST00000398712	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-
In-frame	ENST00000409373	ENST00000398712	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-
In-frame	ENST00000410032	ENST00000398712	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-
In-frame	ENST00000445024	ENST00000398712	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000410032	MLPH	chr2	238419744	+	ENST00000398712	SHARPIN	chr8	145154972	-	1790	838	393	1625	410
ENST00000264605	MLPH	chr2	238419744	+	ENST00000398712	SHARPIN	chr8	145154972	-	1691	739	294	1526	410
ENST00000445024	MLPH	chr2	238419744	+	ENST00000398712	SHARPIN	chr8	145154972	-	1609	657	212	1444	410
ENST00000338530	MLPH	chr2	238419744	+	ENST00000398712	SHARPIN	chr8	145154972	-	1608	656	211	1443	410
ENST00000409373	MLPH	chr2	238419744	+	ENST00000398712	SHARPIN	chr8	145154972	-	1583	631	186	1418	410

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000410032	ENST00000398712	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-	0.19324152	0.8067585
ENST00000264605	ENST00000398712	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-	0.21013698	0.78986305
ENST00000445024	ENST00000398712	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-	0.21407509	0.7859249
ENST00000338530	ENST00000398712	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-	0.21480581	0.7851942
ENST00000409373	ENST00000398712	MLPH	chr2	238419744	+	SHARPIN	chr8	145154972	-	0.21757989	0.78242016

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Fusion Genomic Features for MLPH-SHARPIN

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MLPH-SHARPIN

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:238419744/chr8:145154972)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MLPH Q9BV36	SHARPIN SHARPIN
FUNCTION: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269\|PubMed:12062444}.	387

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MLPH

chr2:238419744

chr8:145154972

ENST00000264605

4_124

148

601.0

Domain

RabBD

Hgene

MLPH

chr2:238419744

chr8:145154972

ENST00000338530

4_124

148

573.0

Domain

RabBD

Hgene

MLPH

chr2:238419744

chr8:145154972

ENST00000409373

4_124

148

481.0

Domain

RabBD

Hgene

MLPH

chr2:238419744

chr8:145154972

ENST00000264605

64_107

148

601.0

Zinc finger

Note=FYVE-type

Hgene

MLPH

chr2:238419744

chr8:145154972

ENST00000338530

64_107

148

573.0

Zinc finger

Note=FYVE-type

Hgene

MLPH

chr2:238419744

chr8:145154972

ENST00000409373

64_107

148

481.0

Zinc finger

Note=FYVE-type

Tgene

SHARPIN

chr2:238419744

chr8:145154972

ENST00000398712

219_288

125

210.66666666666666

Domain

Note=Ubiquitin-like

Tgene

SHARPIN

chr2:238419744

chr8:145154972

ENST00000398712

348_377

125

210.66666666666666

Zinc finger

RanBP2-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MLPH

chr2:238419744

chr8:145154972

ENST00000264605

373_496

148

601.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

MLPH

chr2:238419744

chr8:145154972

ENST00000338530

373_496

148

573.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

MLPH

chr2:238419744

chr8:145154972

ENST00000409373

373_496

148

481.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SHARPIN

chr2:238419744

chr8:145154972

ENST00000398712

1_180

125

210.66666666666666

Region

Self-association

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Fusion Gene Sequence for MLPH-SHARPIN

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>54339_54339_1_MLPH-SHARPIN_MLPH_chr2_238419744_ENST00000264605_SHARPIN_chr8_145154972_ENST00000398712_length(transcript)=1691nt_BP=739nt
ATCCAGAGGTGTCCGCGCTCCCGGAGCTGGGCGGAGCGGGGCGCAGCCCACGTGGTTCGGGCGGGAGGCGCCGGGACGTGGCCAGTTGCC
CGCCTGCCCCGGAGAGCCAGGCGCTAACCAGCCGCTCTGCGCCCCGCGCCCTGCTTGCCCCCATTATCCAGCCTTGCCCCGGCGCCCTGA
CCTGACGCCCTGGCCTGACGCCCTGCTTCGTCGCCTCCTTTCTCTCCCAGGTGCTGGACCAGGGACTGAGCGTCCCCCGGAGAGGGTCCG
GTGTGACCCCGACAAGAAGCAGAAATGGGGAAGAAACTGGATCTTTCCAAGCTCACTGATGAAGAGGCCCAGCATGTCTTGGAAGTTGTT
CAACGAGATTTTGACCTCCGAAGGAAAGAAGAGGAACGGCTAGAGGCGTTGAAGGGCAAGATTAAGAAGGAAAGCTCCAAGAGGGAGCTG
CTTTCCGACACTGCCCATCTGAACGAGACCCACTGCGCCCGCTGCCTGCAGCCCTACCAGCTGCTTGTGAATAGCAAAAGGCAGTGCCTG
GAATGTGGCCTCTTCACCTGCAAAAGCTGTGGCCGCGTCCACCCGGAGGAGCAGGGCTGGATCTGTGACCCCTGCCATCTGGCCAGAGTC
GTGAAGATCGGCTCACTGGAGTGGTACTATGAGCATGTGAAAGCCCGCTTCAAGAGGTTCGGAAGTGCCAAGGTCATCCGGTCCCTCCAC
GGGCGGCTGCAGGGTGGAGGCAGCAAGAGCAACTCACCACCAGCCTTGGGCCCAGAAGCATGCCCTGTCTCCCTGCCCAGTCCCCCGGAA
GCCTCCACACTCAAGGGCCCTCCACCTGAGGCAGATCTTCCTAGGAGCCCTGGAAACTTGACGGAGAGAGAAGAGCTGGCAGGGAGCCTG
GCCCGGGCTATTGCAGGTGGAGACGAGAAGGGGGCAGCCCAAGTGGCAGCCGTCCTGGCCCAGCATCGTGTGGCCCTGAGTGTTCAGCTT
CAGGAGGCCTGCTTCCCACCTGGCCCCATCAGGCTGCAGGTCACACTTGAAGACGCTGCCTCTGCCGCATCCGCCGCGTCCTCTGCACAC
GTTGCCCTGCAGGTCCACCCCCACTGCACTGTTGCAGCTCTCCAGGAGCAGGTGTTCTCAGAGCTCGGTTTCCCGCCAGCCGTGCAACGC
TGGGTCATCGGACGGTGCCTGTGTGTGCCTGAGCGCAGCCTTGCCTCTTACGGGGTTCGGCAGGATGGGGACCCTGCTTTCCTCTACTTG
CTGTCAGCTCCTCGAGAAGCCCCAGCCACAGGACCTAGCCCTCAGCACCCCCAGAAGATGGACGGGGAACTTGGACGCTTGTTTCCCCCA
TCATTGGGGCTACCCCCAGGCCCCCAGCCAGCTGCCTCCAGCCTGCCCAGTCCACTCCAGCCCAGCTGGTCCTGTCCTTCCTGCACCTTC
ATCAATGCCCCAGACCGCCCTGGCTGTGAGATGTGTAGCACCCAGAGGCCCTGCACTTGGGACCCCCTTGCTGCAGCTTCCACCTAGCAG
CCACCAGAGGTTACAAGGGGAGAGTGGCCCTTCCCTCACAAGTCCGACATCTCCAGGCCCCCACTGAACTCCGGGGACCTCTACTGACTG

>54339_54339_1_MLPH-SHARPIN_MLPH_chr2_238419744_ENST00000264605_SHARPIN_chr8_145154972_ENST00000398712_length(amino acids)=410AA_BP=148
MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLNETHCARCLQPYQLLVNSKRQCLECGLFTCK
SCGRVHPEEQGWICDPCHLARVVKIGSLEWYYEHVKARFKRFGSAKVIRSLHGRLQGGGSKSNSPPALGPEACPVSLPSPPEASTLKGPP
PEADLPRSPGNLTEREELAGSLARAIAGGDEKGAAQVAAVLAQHRVALSVQLQEACFPPGPIRLQVTLEDAASAASAASSAHVALQVHPH
CTVAALQEQVFSELGFPPAVQRWVIGRCLCVPERSLASYGVRQDGDPAFLYLLSAPREAPATGPSPQHPQKMDGELGRLFPPSLGLPPGP

--------------------------------------------------------------
>54339_54339_2_MLPH-SHARPIN_MLPH_chr2_238419744_ENST00000338530_SHARPIN_chr8_145154972_ENST00000398712_length(transcript)=1608nt_BP=656nt
AGTTGCCCGCCTGCCCCGGAGAGCCAGGCGCTAACCAGCCGCTCTGCGCCCCGCGCCCTGCTTGCCCCCATTATCCAGCCTTGCCCCGGC
GCCCTGACCTGACGCCCTGGCCTGACGCCCTGCTTCGTCGCCTCCTTTCTCTCCCAGGTGCTGGACCAGGGACTGAGCGTCCCCCGGAGA
GGGTCCGGTGTGACCCCGACAAGAAGCAGAAATGGGGAAGAAACTGGATCTTTCCAAGCTCACTGATGAAGAGGCCCAGCATGTCTTGGA
AGTTGTTCAACGAGATTTTGACCTCCGAAGGAAAGAAGAGGAACGGCTAGAGGCGTTGAAGGGCAAGATTAAGAAGGAAAGCTCCAAGAG
GGAGCTGCTTTCCGACACTGCCCATCTGAACGAGACCCACTGCGCCCGCTGCCTGCAGCCCTACCAGCTGCTTGTGAATAGCAAAAGGCA
GTGCCTGGAATGTGGCCTCTTCACCTGCAAAAGCTGTGGCCGCGTCCACCCGGAGGAGCAGGGCTGGATCTGTGACCCCTGCCATCTGGC
CAGAGTCGTGAAGATCGGCTCACTGGAGTGGTACTATGAGCATGTGAAAGCCCGCTTCAAGAGGTTCGGAAGTGCCAAGGTCATCCGGTC
CCTCCACGGGCGGCTGCAGGGTGGAGGCAGCAAGAGCAACTCACCACCAGCCTTGGGCCCAGAAGCATGCCCTGTCTCCCTGCCCAGTCC
CCCGGAAGCCTCCACACTCAAGGGCCCTCCACCTGAGGCAGATCTTCCTAGGAGCCCTGGAAACTTGACGGAGAGAGAAGAGCTGGCAGG
GAGCCTGGCCCGGGCTATTGCAGGTGGAGACGAGAAGGGGGCAGCCCAAGTGGCAGCCGTCCTGGCCCAGCATCGTGTGGCCCTGAGTGT
TCAGCTTCAGGAGGCCTGCTTCCCACCTGGCCCCATCAGGCTGCAGGTCACACTTGAAGACGCTGCCTCTGCCGCATCCGCCGCGTCCTC
TGCACACGTTGCCCTGCAGGTCCACCCCCACTGCACTGTTGCAGCTCTCCAGGAGCAGGTGTTCTCAGAGCTCGGTTTCCCGCCAGCCGT
GCAACGCTGGGTCATCGGACGGTGCCTGTGTGTGCCTGAGCGCAGCCTTGCCTCTTACGGGGTTCGGCAGGATGGGGACCCTGCTTTCCT
CTACTTGCTGTCAGCTCCTCGAGAAGCCCCAGCCACAGGACCTAGCCCTCAGCACCCCCAGAAGATGGACGGGGAACTTGGACGCTTGTT
TCCCCCATCATTGGGGCTACCCCCAGGCCCCCAGCCAGCTGCCTCCAGCCTGCCCAGTCCACTCCAGCCCAGCTGGTCCTGTCCTTCCTG
CACCTTCATCAATGCCCCAGACCGCCCTGGCTGTGAGATGTGTAGCACCCAGAGGCCCTGCACTTGGGACCCCCTTGCTGCAGCTTCCAC
CTAGCAGCCACCAGAGGTTACAAGGGGAGAGTGGCCCTTCCCTCACAAGTCCGACATCTCCAGGCCCCCACTGAACTCCGGGGACCTCTA

>54339_54339_2_MLPH-SHARPIN_MLPH_chr2_238419744_ENST00000338530_SHARPIN_chr8_145154972_ENST00000398712_length(amino acids)=410AA_BP=148
MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLNETHCARCLQPYQLLVNSKRQCLECGLFTCK
SCGRVHPEEQGWICDPCHLARVVKIGSLEWYYEHVKARFKRFGSAKVIRSLHGRLQGGGSKSNSPPALGPEACPVSLPSPPEASTLKGPP
PEADLPRSPGNLTEREELAGSLARAIAGGDEKGAAQVAAVLAQHRVALSVQLQEACFPPGPIRLQVTLEDAASAASAASSAHVALQVHPH
CTVAALQEQVFSELGFPPAVQRWVIGRCLCVPERSLASYGVRQDGDPAFLYLLSAPREAPATGPSPQHPQKMDGELGRLFPPSLGLPPGP

--------------------------------------------------------------
>54339_54339_3_MLPH-SHARPIN_MLPH_chr2_238419744_ENST00000409373_SHARPIN_chr8_145154972_ENST00000398712_length(transcript)=1583nt_BP=631nt
AGGCGCTAACCAGCCGCTCTGCGCCCCGCGCCCTGCTTGCCCCCATTATCCAGCCTTGCCCCGGCGCCCTGACCTGACGCCCTGGCCTGA
CGCCCTGCTTCGTCGCCTCCTTTCTCTCCCAGGTGCTGGACCAGGGACTGAGCGTCCCCCGGAGAGGGTCCGGTGTGACCCCGACAAGAA
GCAGAAATGGGGAAGAAACTGGATCTTTCCAAGCTCACTGATGAAGAGGCCCAGCATGTCTTGGAAGTTGTTCAACGAGATTTTGACCTC
CGAAGGAAAGAAGAGGAACGGCTAGAGGCGTTGAAGGGCAAGATTAAGAAGGAAAGCTCCAAGAGGGAGCTGCTTTCCGACACTGCCCAT
CTGAACGAGACCCACTGCGCCCGCTGCCTGCAGCCCTACCAGCTGCTTGTGAATAGCAAAAGGCAGTGCCTGGAATGTGGCCTCTTCACC
TGCAAAAGCTGTGGCCGCGTCCACCCGGAGGAGCAGGGCTGGATCTGTGACCCCTGCCATCTGGCCAGAGTCGTGAAGATCGGCTCACTG
GAGTGGTACTATGAGCATGTGAAAGCCCGCTTCAAGAGGTTCGGAAGTGCCAAGGTCATCCGGTCCCTCCACGGGCGGCTGCAGGGTGGA
GGCAGCAAGAGCAACTCACCACCAGCCTTGGGCCCAGAAGCATGCCCTGTCTCCCTGCCCAGTCCCCCGGAAGCCTCCACACTCAAGGGC
CCTCCACCTGAGGCAGATCTTCCTAGGAGCCCTGGAAACTTGACGGAGAGAGAAGAGCTGGCAGGGAGCCTGGCCCGGGCTATTGCAGGT
GGAGACGAGAAGGGGGCAGCCCAAGTGGCAGCCGTCCTGGCCCAGCATCGTGTGGCCCTGAGTGTTCAGCTTCAGGAGGCCTGCTTCCCA
CCTGGCCCCATCAGGCTGCAGGTCACACTTGAAGACGCTGCCTCTGCCGCATCCGCCGCGTCCTCTGCACACGTTGCCCTGCAGGTCCAC
CCCCACTGCACTGTTGCAGCTCTCCAGGAGCAGGTGTTCTCAGAGCTCGGTTTCCCGCCAGCCGTGCAACGCTGGGTCATCGGACGGTGC
CTGTGTGTGCCTGAGCGCAGCCTTGCCTCTTACGGGGTTCGGCAGGATGGGGACCCTGCTTTCCTCTACTTGCTGTCAGCTCCTCGAGAA
GCCCCAGCCACAGGACCTAGCCCTCAGCACCCCCAGAAGATGGACGGGGAACTTGGACGCTTGTTTCCCCCATCATTGGGGCTACCCCCA
GGCCCCCAGCCAGCTGCCTCCAGCCTGCCCAGTCCACTCCAGCCCAGCTGGTCCTGTCCTTCCTGCACCTTCATCAATGCCCCAGACCGC
CCTGGCTGTGAGATGTGTAGCACCCAGAGGCCCTGCACTTGGGACCCCCTTGCTGCAGCTTCCACCTAGCAGCCACCAGAGGTTACAAGG
GGAGAGTGGCCCTTCCCTCACAAGTCCGACATCTCCAGGCCCCCACTGAACTCCGGGGACCTCTACTGACTGCTTGCTGGGACAGTCACC

>54339_54339_3_MLPH-SHARPIN_MLPH_chr2_238419744_ENST00000409373_SHARPIN_chr8_145154972_ENST00000398712_length(amino acids)=410AA_BP=148
MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLNETHCARCLQPYQLLVNSKRQCLECGLFTCK
SCGRVHPEEQGWICDPCHLARVVKIGSLEWYYEHVKARFKRFGSAKVIRSLHGRLQGGGSKSNSPPALGPEACPVSLPSPPEASTLKGPP
PEADLPRSPGNLTEREELAGSLARAIAGGDEKGAAQVAAVLAQHRVALSVQLQEACFPPGPIRLQVTLEDAASAASAASSAHVALQVHPH
CTVAALQEQVFSELGFPPAVQRWVIGRCLCVPERSLASYGVRQDGDPAFLYLLSAPREAPATGPSPQHPQKMDGELGRLFPPSLGLPPGP

--------------------------------------------------------------
>54339_54339_4_MLPH-SHARPIN_MLPH_chr2_238419744_ENST00000410032_SHARPIN_chr8_145154972_ENST00000398712_length(transcript)=1790nt_BP=838nt
ATTGGAATTCGGAAGGACAGGCAGGCCGGGCGGACTGGAGACGGCGGCTCGCCTTGGGACCCTCTGAGCTTGCGGGCCCCGCTGAGCACC
CAAAGGCCGGCCCTAGAGTCCAGGAGAAGAGCGCAGCGGCGCGGAGCTCCCAGGCGTTCCCCGCAGCGCGTCCTCGGTCCTGGAACCACC
GCGCCGCGCGTCCTGGCTTCCACATCTGCCCCATTTGCCCGCGGATCTTGACTTTTTCTTGGCGGGCAAGGCCTCGGTCTCCTCCCCGCA
GCAGGGCTGCCCGCGGCTGCGGGACCCTCCTGGTCCTGATGCCTGGCAGAATCGAAGGGGTGCTGGACCAGGGACTGAGCGTCCCCCGGA
GAGGGTCCGGTGTGACCCCGACAAGAAGCAGAAATGGGGAAGAAACTGGATCTTTCCAAGCTCACTGATGAAGAGGCCCAGCATGTCTTG
GAAGTTGTTCAACGAGATTTTGACCTCCGAAGGAAAGAAGAGGAACGGCTAGAGGCGTTGAAGGGCAAGATTAAGAAGGAAAGCTCCAAG
AGGGAGCTGCTTTCCGACACTGCCCATCTGAACGAGACCCACTGCGCCCGCTGCCTGCAGCCCTACCAGCTGCTTGTGAATAGCAAAAGG
CAGTGCCTGGAATGTGGCCTCTTCACCTGCAAAAGCTGTGGCCGCGTCCACCCGGAGGAGCAGGGCTGGATCTGTGACCCCTGCCATCTG
GCCAGAGTCGTGAAGATCGGCTCACTGGAGTGGTACTATGAGCATGTGAAAGCCCGCTTCAAGAGGTTCGGAAGTGCCAAGGTCATCCGG
TCCCTCCACGGGCGGCTGCAGGGTGGAGGCAGCAAGAGCAACTCACCACCAGCCTTGGGCCCAGAAGCATGCCCTGTCTCCCTGCCCAGT
CCCCCGGAAGCCTCCACACTCAAGGGCCCTCCACCTGAGGCAGATCTTCCTAGGAGCCCTGGAAACTTGACGGAGAGAGAAGAGCTGGCA
GGGAGCCTGGCCCGGGCTATTGCAGGTGGAGACGAGAAGGGGGCAGCCCAAGTGGCAGCCGTCCTGGCCCAGCATCGTGTGGCCCTGAGT
GTTCAGCTTCAGGAGGCCTGCTTCCCACCTGGCCCCATCAGGCTGCAGGTCACACTTGAAGACGCTGCCTCTGCCGCATCCGCCGCGTCC
TCTGCACACGTTGCCCTGCAGGTCCACCCCCACTGCACTGTTGCAGCTCTCCAGGAGCAGGTGTTCTCAGAGCTCGGTTTCCCGCCAGCC
GTGCAACGCTGGGTCATCGGACGGTGCCTGTGTGTGCCTGAGCGCAGCCTTGCCTCTTACGGGGTTCGGCAGGATGGGGACCCTGCTTTC
CTCTACTTGCTGTCAGCTCCTCGAGAAGCCCCAGCCACAGGACCTAGCCCTCAGCACCCCCAGAAGATGGACGGGGAACTTGGACGCTTG
TTTCCCCCATCATTGGGGCTACCCCCAGGCCCCCAGCCAGCTGCCTCCAGCCTGCCCAGTCCACTCCAGCCCAGCTGGTCCTGTCCTTCC
TGCACCTTCATCAATGCCCCAGACCGCCCTGGCTGTGAGATGTGTAGCACCCAGAGGCCCTGCACTTGGGACCCCCTTGCTGCAGCTTCC
ACCTAGCAGCCACCAGAGGTTACAAGGGGAGAGTGGCCCTTCCCTCACAAGTCCGACATCTCCAGGCCCCCACTGAACTCCGGGGACCTC

>54339_54339_4_MLPH-SHARPIN_MLPH_chr2_238419744_ENST00000410032_SHARPIN_chr8_145154972_ENST00000398712_length(amino acids)=410AA_BP=148
MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLNETHCARCLQPYQLLVNSKRQCLECGLFTCK
SCGRVHPEEQGWICDPCHLARVVKIGSLEWYYEHVKARFKRFGSAKVIRSLHGRLQGGGSKSNSPPALGPEACPVSLPSPPEASTLKGPP
PEADLPRSPGNLTEREELAGSLARAIAGGDEKGAAQVAAVLAQHRVALSVQLQEACFPPGPIRLQVTLEDAASAASAASSAHVALQVHPH
CTVAALQEQVFSELGFPPAVQRWVIGRCLCVPERSLASYGVRQDGDPAFLYLLSAPREAPATGPSPQHPQKMDGELGRLFPPSLGLPPGP

--------------------------------------------------------------
>54339_54339_5_MLPH-SHARPIN_MLPH_chr2_238419744_ENST00000445024_SHARPIN_chr8_145154972_ENST00000398712_length(transcript)=1609nt_BP=657nt
CAGTTGCCCGCCTGCCCCGGAGAGCCAGGCGCTAACCAGCCGCTCTGCGCCCCGCGCCCTGCTTGCCCCCATTATCCAGCCTTGCCCCGG
CGCCCTGACCTGACGCCCTGGCCTGACGCCCTGCTTCGTCGCCTCCTTTCTCTCCCAGGTGCTGGACCAGGGACTGAGCGTCCCCCGGAG
AGGGTCCGGTGTGACCCCGACAAGAAGCAGAAATGGGGAAGAAACTGGATCTTTCCAAGCTCACTGATGAAGAGGCCCAGCATGTCTTGG
AAGTTGTTCAACGAGATTTTGACCTCCGAAGGAAAGAAGAGGAACGGCTAGAGGCGTTGAAGGGCAAGATTAAGAAGGAAAGCTCCAAGA
GGGAGCTGCTTTCCGACACTGCCCATCTGAACGAGACCCACTGCGCCCGCTGCCTGCAGCCCTACCAGCTGCTTGTGAATAGCAAAAGGC
AGTGCCTGGAATGTGGCCTCTTCACCTGCAAAAGCTGTGGCCGCGTCCACCCGGAGGAGCAGGGCTGGATCTGTGACCCCTGCCATCTGG
CCAGAGTCGTGAAGATCGGCTCACTGGAGTGGTACTATGAGCATGTGAAAGCCCGCTTCAAGAGGTTCGGAAGTGCCAAGGTCATCCGGT
CCCTCCACGGGCGGCTGCAGGGTGGAGGCAGCAAGAGCAACTCACCACCAGCCTTGGGCCCAGAAGCATGCCCTGTCTCCCTGCCCAGTC
CCCCGGAAGCCTCCACACTCAAGGGCCCTCCACCTGAGGCAGATCTTCCTAGGAGCCCTGGAAACTTGACGGAGAGAGAAGAGCTGGCAG
GGAGCCTGGCCCGGGCTATTGCAGGTGGAGACGAGAAGGGGGCAGCCCAAGTGGCAGCCGTCCTGGCCCAGCATCGTGTGGCCCTGAGTG
TTCAGCTTCAGGAGGCCTGCTTCCCACCTGGCCCCATCAGGCTGCAGGTCACACTTGAAGACGCTGCCTCTGCCGCATCCGCCGCGTCCT
CTGCACACGTTGCCCTGCAGGTCCACCCCCACTGCACTGTTGCAGCTCTCCAGGAGCAGGTGTTCTCAGAGCTCGGTTTCCCGCCAGCCG
TGCAACGCTGGGTCATCGGACGGTGCCTGTGTGTGCCTGAGCGCAGCCTTGCCTCTTACGGGGTTCGGCAGGATGGGGACCCTGCTTTCC
TCTACTTGCTGTCAGCTCCTCGAGAAGCCCCAGCCACAGGACCTAGCCCTCAGCACCCCCAGAAGATGGACGGGGAACTTGGACGCTTGT
TTCCCCCATCATTGGGGCTACCCCCAGGCCCCCAGCCAGCTGCCTCCAGCCTGCCCAGTCCACTCCAGCCCAGCTGGTCCTGTCCTTCCT
GCACCTTCATCAATGCCCCAGACCGCCCTGGCTGTGAGATGTGTAGCACCCAGAGGCCCTGCACTTGGGACCCCCTTGCTGCAGCTTCCA
CCTAGCAGCCACCAGAGGTTACAAGGGGAGAGTGGCCCTTCCCTCACAAGTCCGACATCTCCAGGCCCCCACTGAACTCCGGGGACCTCT

>54339_54339_5_MLPH-SHARPIN_MLPH_chr2_238419744_ENST00000445024_SHARPIN_chr8_145154972_ENST00000398712_length(amino acids)=410AA_BP=148
MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLNETHCARCLQPYQLLVNSKRQCLECGLFTCK
SCGRVHPEEQGWICDPCHLARVVKIGSLEWYYEHVKARFKRFGSAKVIRSLHGRLQGGGSKSNSPPALGPEACPVSLPSPPEASTLKGPP
PEADLPRSPGNLTEREELAGSLARAIAGGDEKGAAQVAAVLAQHRVALSVQLQEACFPPGPIRLQVTLEDAASAASAASSAHVALQVHPH
CTVAALQEQVFSELGFPPAVQRWVIGRCLCVPERSLASYGVRQDGDPAFLYLLSAPREAPATGPSPQHPQKMDGELGRLFPPSLGLPPGP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MLPH-SHARPIN

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	SHARPIN	chr2:238419744	chr8:145154972	ENST00000398712		1	9	175_310	125.33333333333333	210.66666666666666	SHANK1

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MLPH-SHARPIN

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MLPH-SHARPIN

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source