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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MLTK-RAPGEF4 (FusionGDB2 ID:54347)

Fusion Gene Summary for MLTK-RAPGEF4

check button Fusion gene summary
Fusion gene informationFusion gene name: MLTK-RAPGEF4
Fusion gene ID: 54347
HgeneTgene
Gene symbol

MLTK

RAPGEF4

Gene ID

51776

11069

Gene namemitogen-activated protein kinase kinase kinase 20Rap guanine nucleotide exchange factor 4
SynonymsAZK|CNM6|MLK7|MLT|MLTK|MLTKalpha|MLTKbeta|MRK|SFMMP|ZAK|mlklak|pkCAMP-GEFII|CGEF2|EPAC|EPAC 2|EPAC2|Nbla00496
Cytomap

2q31.1

2q31.1

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase 20HCCS-4MLK-like mitogen-activated protein triple kinaseZAK1 homolog, leucine zipper and sterile-alpha motif kinasehuman cervical cancer suppressor gene 4 proteinmitogen-activated protein kinase kinase krap guanine nucleotide exchange factor 4RAP guanine-nucleotide-exchange factor (GEF) 4Rap guanine nucleotide exchange factor (GEF) 4cAMP-regulated guanine nucleotide exchange factor IIexchange factor directly activated by cAMP 2exchange protein direc
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000338983, ENST00000375213, 
ENST00000409176, ENST00000539448, 
ENST00000431503, ENST00000480606, 
ENST00000473043, ENST00000535187, 
ENST00000538974, ENST00000539331, 
ENST00000540783, ENST00000264111, 
ENST00000397081, ENST00000397087, 
ENST00000409036, 
Fusion gene scores* DoF score4 X 2 X 3=2417 X 18 X 9=2754
# samples 419
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(19/2754*10)=-3.85745723580402
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MLTK [Title/Abstract] AND RAPGEF4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMLTK(173955918)-RAPGEF4(173825488), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMLTK

GO:0006468

protein phosphorylation

11836244

HgeneMLTK

GO:0007093

mitotic cell cycle checkpoint

15342622

HgeneMLTK

GO:0007257

activation of JUN kinase activity

11836244

HgeneMLTK

GO:0043065

positive regulation of apoptotic process

10924358

HgeneMLTK

GO:0051403

stress-activated MAPK cascade

11836244

HgeneMLTK

GO:0071480

cellular response to gamma radiation

11836244


check buttonFusion gene breakpoints across MLTK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAPGEF4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A140-01AMLTKchr2

173955918

+RAPGEF4chr2

173825488

+


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Fusion Gene ORF analysis for MLTK-RAPGEF4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000338983ENST00000473043MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000338983ENST00000535187MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000338983ENST00000538974MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000338983ENST00000539331MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000338983ENST00000540783MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000375213ENST00000473043MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000375213ENST00000535187MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000375213ENST00000538974MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000375213ENST00000539331MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000375213ENST00000540783MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000409176ENST00000473043MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000409176ENST00000535187MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000409176ENST00000538974MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000409176ENST00000539331MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000409176ENST00000540783MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000539448ENST00000473043MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000539448ENST00000535187MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000539448ENST00000538974MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000539448ENST00000539331MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
5CDS-intronENST00000539448ENST00000540783MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
In-frameENST00000338983ENST00000264111MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
In-frameENST00000338983ENST00000397081MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
In-frameENST00000338983ENST00000397087MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
In-frameENST00000338983ENST00000409036MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
In-frameENST00000375213ENST00000264111MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
In-frameENST00000375213ENST00000397081MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
In-frameENST00000375213ENST00000397087MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
In-frameENST00000375213ENST00000409036MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
In-frameENST00000409176ENST00000264111MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
In-frameENST00000409176ENST00000397081MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
In-frameENST00000409176ENST00000397087MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
In-frameENST00000409176ENST00000409036MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
In-frameENST00000539448ENST00000264111MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
In-frameENST00000539448ENST00000397081MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
In-frameENST00000539448ENST00000397087MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
In-frameENST00000539448ENST00000409036MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-3CDSENST00000431503ENST00000264111MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-3CDSENST00000431503ENST00000397081MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-3CDSENST00000431503ENST00000397087MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-3CDSENST00000431503ENST00000409036MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-3CDSENST00000480606ENST00000264111MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-3CDSENST00000480606ENST00000397081MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-3CDSENST00000480606ENST00000397087MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-3CDSENST00000480606ENST00000409036MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-intronENST00000431503ENST00000473043MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-intronENST00000431503ENST00000535187MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-intronENST00000431503ENST00000538974MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-intronENST00000431503ENST00000539331MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-intronENST00000431503ENST00000540783MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-intronENST00000480606ENST00000473043MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-intronENST00000480606ENST00000535187MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-intronENST00000480606ENST00000538974MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-intronENST00000480606ENST00000539331MLTKchr2

173955918

+RAPGEF4chr2

173825488

+
intron-intronENST00000480606ENST00000540783MLTKchr2

173955918

+RAPGEF4chr2

173825488

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000539448MLTKchr2173955918+ENST00000264111RAPGEF4chr2173825488+40464291862927913
ENST00000539448MLTKchr2173955918+ENST00000397081RAPGEF4chr2173825488+40484291862927913
ENST00000539448MLTKchr2173955918+ENST00000409036RAPGEF4chr2173825488+38504291862723845
ENST00000539448MLTKchr2173955918+ENST00000397087RAPGEF4chr2173825488+40544291862927913
ENST00000409176MLTKchr2173955918+ENST00000264111RAPGEF4chr2173825488+39122951362793885
ENST00000409176MLTKchr2173955918+ENST00000397081RAPGEF4chr2173825488+39142951362793885
ENST00000409176MLTKchr2173955918+ENST00000409036RAPGEF4chr2173825488+37162951362589817
ENST00000409176MLTKchr2173955918+ENST00000397087RAPGEF4chr2173825488+39202951362793885
ENST00000338983MLTKchr2173955918+ENST00000264111RAPGEF4chr2173825488+3971354782852924
ENST00000338983MLTKchr2173955918+ENST00000397081RAPGEF4chr2173825488+3973354782852924
ENST00000338983MLTKchr2173955918+ENST00000409036RAPGEF4chr2173825488+3775354782648856
ENST00000338983MLTKchr2173955918+ENST00000397087RAPGEF4chr2173825488+3979354782852924
ENST00000375213MLTKchr2173955918+ENST00000264111RAPGEF4chr2173825488+3854237152735906
ENST00000375213MLTKchr2173955918+ENST00000397081RAPGEF4chr2173825488+3856237152735906
ENST00000375213MLTKchr2173955918+ENST00000409036RAPGEF4chr2173825488+3658237152531838
ENST00000375213MLTKchr2173955918+ENST00000397087RAPGEF4chr2173825488+3862237152735906

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000539448ENST00000264111MLTKchr2173955918+RAPGEF4chr2173825488+0.0004431730.99955684
ENST00000539448ENST00000397081MLTKchr2173955918+RAPGEF4chr2173825488+0.0004455840.99955446
ENST00000539448ENST00000409036MLTKchr2173955918+RAPGEF4chr2173825488+0.0004980750.99950194
ENST00000539448ENST00000397087MLTKchr2173955918+RAPGEF4chr2173825488+0.000447860.9995521
ENST00000409176ENST00000264111MLTKchr2173955918+RAPGEF4chr2173825488+0.0004198660.9995801
ENST00000409176ENST00000397081MLTKchr2173955918+RAPGEF4chr2173825488+0.0004230120.999577
ENST00000409176ENST00000409036MLTKchr2173955918+RAPGEF4chr2173825488+0.0004644360.99953556
ENST00000409176ENST00000397087MLTKchr2173955918+RAPGEF4chr2173825488+0.0004255910.99957436
ENST00000338983ENST00000264111MLTKchr2173955918+RAPGEF4chr2173825488+0.0004622080.9995378
ENST00000338983ENST00000397081MLTKchr2173955918+RAPGEF4chr2173825488+0.0004652840.9995347
ENST00000338983ENST00000409036MLTKchr2173955918+RAPGEF4chr2173825488+0.0005173350.99948263
ENST00000338983ENST00000397087MLTKchr2173955918+RAPGEF4chr2173825488+0.0004682730.99953175
ENST00000375213ENST00000264111MLTKchr2173955918+RAPGEF4chr2173825488+0.0004860420.999514
ENST00000375213ENST00000397081MLTKchr2173955918+RAPGEF4chr2173825488+0.0004875130.99951243
ENST00000375213ENST00000409036MLTKchr2173955918+RAPGEF4chr2173825488+0.0005419560.999458
ENST00000375213ENST00000397087MLTKchr2173955918+RAPGEF4chr2173825488+0.000491270.99950874

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Fusion Genomic Features for MLTK-RAPGEF4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MLTK-RAPGEF4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:173955918/chr2:173825488)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMLTKchr2:173955918chr2:173825488ENST00000375213+22022_3053801.0Nucleotide bindingATP
HgeneMLTKchr2:173955918chr2:173825488ENST00000409176+22022_3053801.0Nucleotide bindingATP
TgeneRAPGEF4chr2:173955918chr2:173825488ENST00000397081531216_2911791012.0DomainDEP
TgeneRAPGEF4chr2:173955918chr2:173825488ENST00000397081531496_6341791012.0DomainN-terminal Ras-GEF
TgeneRAPGEF4chr2:173955918chr2:173825488ENST00000397081531772_10091791012.0DomainRas-GEF
TgeneRAPGEF4chr2:173955918chr2:173825488ENST00000397087228216_29135868.0DomainDEP
TgeneRAPGEF4chr2:173955918chr2:173825488ENST00000397087228496_63435868.0DomainN-terminal Ras-GEF
TgeneRAPGEF4chr2:173955918chr2:173825488ENST00000397087228772_100935868.0DomainRas-GEF
TgeneRAPGEF4chr2:173955918chr2:173825488ENST00000397081531356_4761791012.0Nucleotide bindingNote=cAMP 2
TgeneRAPGEF4chr2:173955918chr2:173825488ENST00000397087228356_47635868.0Nucleotide bindingNote=cAMP 2
TgeneRAPGEF4chr2:173955918chr2:173825488ENST0000039708722843_16635868.0Nucleotide bindingNote=cAMP 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMLTKchr2:173955918chr2:173825488ENST00000375213+22016_27753801.0DomainProtein kinase
HgeneMLTKchr2:173955918chr2:173825488ENST00000375213+220339_41053801.0DomainSAM
HgeneMLTKchr2:173955918chr2:173825488ENST00000409176+22016_27753801.0DomainProtein kinase
HgeneMLTKchr2:173955918chr2:173825488ENST00000409176+220339_41053801.0DomainSAM
HgeneMLTKchr2:173955918chr2:173825488ENST00000375213+220287_30853801.0RegionNote=Leucine-zipper
HgeneMLTKchr2:173955918chr2:173825488ENST00000409176+220287_30853801.0RegionNote=Leucine-zipper
TgeneRAPGEF4chr2:173955918chr2:173825488ENST0000039708153143_1661791012.0Nucleotide bindingNote=cAMP 1


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Fusion Gene Sequence for MLTK-RAPGEF4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54347_54347_1_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000338983_RAPGEF4_chr2_173825488_ENST00000264111_length(transcript)=3971nt_BP=354nt
CTTCCTCATTGGCGCCGTGCAGAGAGGCGGAATGTTCAACTCCTAACTGCAGCGGAAACGTGGGAGCCGCGCGGGCCGCTGTCGTCCCAA
CCCCCGCCGCCCTCGTCGCGCGCGGGGCCTCCGCGCCCCCGGCTGCTGCTCACGCCCCGCCCGGGAGCCAGATTTTGTGGAAGTATAATA
CTTTGTCATTATGAGATGTCGTCTCTCGGTGCCTCCTTTGTGCAAATTAAATTTGATGACTTGCAGTTTTTTGAAAACTGCGGTGGAGGA
AGTTTTGGGAGTGTTTATCGAGCCAAATGGATATCACAGGACAAGGAGGTGGCTGTAAAGAAGCTCCTCAAAATAGAGAAAGAGACACCT
CTCATTGAACCTCACGTTCCTCTTCGTCCTGCTAACACCATTACCAAGGTCCCTTCAGAGAAGATCCTCAGAGCTGGAAAAATTTTACGA
AATGCCATTCTCTCTCGAGCACCTCACATGATAAGAGATAGAAAATACCACCTAAAGACATACAGACAATGCTGTGTGGGAACTGAACTG
GTGGACTGGATGATGCAGCAGACACCATGTGTTCACTCCCGGACTCAAGCTGTTGGCATGTGGCAAGTCCTGTTAGAAGATGGTGTTCTC
AACCACGTGGACCAGGAGCACCATTTCCAAGACAAATATTTATTCTATCGATTTCTGGATGATGAGCACGAGGATGCCCCTTTGCCTACT
GAGGAGGAGAAGAAGGAGTGTGATGAGGAGCTCCAGGACACCATGCTGCTGCTGTCACAGATGGGCCCCGACGCCCACATGAGGATGATC
CTTCGCAAACCACCTGGCCAGAGGACTGTGGATGACCTAGAGATTATCTATGAGGAGCTTCTTCATATTAAAGCCTTATCCCATCTTTCT
ACCACAGTGAAACGAGAGTTAGCAGGTGTTCTCATTTTTGAGTCTCACGCCAAAGGAGGGACTGTGTTGTTTAACCAGGGGGAAGAAGGT
ACCTCCTGGTACATTATTCTAAAAGGATCAGTGAATGTAGTCATTTACGGCAAGGGTGTGGTCTGCACCCTGCATGAAGGAGATGACTTC
GGCAAGTTAGCACTAGTGAATGATGCCCCACGAGCTGCCTCTATCGTCTTACGAGAAGATAACTGCCATTTCTTAAGAGTAGACAAGGAG
GATTTCAACCGGATCCTAAGGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCA
GCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCAT
TTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATG
CCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTC
AACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTC
CTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAG
CAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGC
CAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCG
GTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTG
GTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTG
ACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACA
ATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCA
AACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTT
CAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGT
AACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCAAGTTCAAGAAGTTCTATGCGGAGTTTGAAAGTTTAATGGAC
CCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAACCTCCTCTCATCCCCTTCATGCCTTTGCTCATTAAAGATATG
ACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACTTTGAAAAAATGCGCATGATTGCAAATACGGCCAGAACAGTG
AGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAAT
GTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTT
TGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACAC
ATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAG
CTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACGTGAAGAG
TTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAGTGTTTATGGGATGAGATGTGCTACAAATGGG
ATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTGGAGCCTGGGGTTTCGGGAAGGTGTTGAGGAATCTATAGAAGTCCAAATTAT
AGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAGGAATAGAACCTGACCACATTATTATGAAACATTATGGCTGTTTATGTAATT
TAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAATAATATTTATGTTTACAATGTAACTTTTCAAAATTTACAAATCAGGATTAT
ATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAAATTTGCCAGCGTTAAAGTAGAAAATAACATTTCAGAAGAGCACAATATGCA
TAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATTAAAAACCTTTACTATTGGCTACAAATTTATTGTACCTGATGAAAACATATT
TTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCAGTAATTGTTTTGCACTTTCAAAGATTGTAAATAGTTCATTCAATCAATGGT
ATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCAAATAATTACTTTTTATTTATTTTATTTAGTACGTAATTTTGAAGTACATTT
TTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGGAATTGTATGTATGTATATCTTCTGTAAATAACATCTAGTATCTTCACTAAA

>54347_54347_1_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000338983_RAPGEF4_chr2_173825488_ENST00000264111_length(amino acids)=924AA_BP=92
MSSQPPPPSSRAGPPRPRLLLTPRPGARFCGSIILCHYEMSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE
KETPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLE
DGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKAL
SHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLR
VDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMH
CVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELE
KIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSG
GEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFK
KTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFE
SLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYV

--------------------------------------------------------------
>54347_54347_2_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000338983_RAPGEF4_chr2_173825488_ENST00000397081_length(transcript)=3973nt_BP=354nt
CTTCCTCATTGGCGCCGTGCAGAGAGGCGGAATGTTCAACTCCTAACTGCAGCGGAAACGTGGGAGCCGCGCGGGCCGCTGTCGTCCCAA
CCCCCGCCGCCCTCGTCGCGCGCGGGGCCTCCGCGCCCCCGGCTGCTGCTCACGCCCCGCCCGGGAGCCAGATTTTGTGGAAGTATAATA
CTTTGTCATTATGAGATGTCGTCTCTCGGTGCCTCCTTTGTGCAAATTAAATTTGATGACTTGCAGTTTTTTGAAAACTGCGGTGGAGGA
AGTTTTGGGAGTGTTTATCGAGCCAAATGGATATCACAGGACAAGGAGGTGGCTGTAAAGAAGCTCCTCAAAATAGAGAAAGAGACACCT
CTCATTGAACCTCACGTTCCTCTTCGTCCTGCTAACACCATTACCAAGGTCCCTTCAGAGAAGATCCTCAGAGCTGGAAAAATTTTACGA
AATGCCATTCTCTCTCGAGCACCTCACATGATAAGAGATAGAAAATACCACCTAAAGACATACAGACAATGCTGTGTGGGAACTGAACTG
GTGGACTGGATGATGCAGCAGACACCATGTGTTCACTCCCGGACTCAAGCTGTTGGCATGTGGCAAGTCCTGTTAGAAGATGGTGTTCTC
AACCACGTGGACCAGGAGCACCATTTCCAAGACAAATATTTATTCTATCGATTTCTGGATGATGAGCACGAGGATGCCCCTTTGCCTACT
GAGGAGGAGAAGAAGGAGTGTGATGAGGAGCTCCAGGACACCATGCTGCTGCTGTCACAGATGGGCCCCGACGCCCACATGAGGATGATC
CTTCGCAAACCACCTGGCCAGAGGACTGTGGATGACCTAGAGATTATCTATGAGGAGCTTCTTCATATTAAAGCCTTATCCCATCTTTCT
ACCACAGTGAAACGAGAGTTAGCAGGTGTTCTCATTTTTGAGTCTCACGCCAAAGGAGGGACTGTGTTGTTTAACCAGGGGGAAGAAGGT
ACCTCCTGGTACATTATTCTAAAAGGATCAGTGAATGTAGTCATTTACGGCAAGGGTGTGGTCTGCACCCTGCATGAAGGAGATGACTTC
GGCAAGTTAGCACTAGTGAATGATGCCCCACGAGCTGCCTCTATCGTCTTACGAGAAGATAACTGCCATTTCTTAAGAGTAGACAAGGAG
GATTTCAACCGGATCCTAAGGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCA
GCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCAT
TTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATG
CCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTC
AACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTC
CTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAG
CAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGC
CAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCG
GTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTG
GTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTG
ACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACA
ATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCA
AACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTT
CAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGT
AACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCAAGTTCAAGAAGTTCTATGCGGAGTTTGAAAGTTTAATGGAC
CCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAACCTCCTCTCATCCCCTTCATGCCTTTGCTCATTAAAGATATG
ACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACTTTGAAAAAATGCGCATGATTGCAAATACGGCCAGAACAGTG
AGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAAT
GTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTT
TGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACAC
ATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAG
CTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACGTGAAGAG
TTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAGTGTTTATGGGATGAGATGTGCTACAAATGGG
ATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTGGAGCCTGGGGTTTCGGGAAGGTGTTGAGGAATCTATAGAAGTCCAAATTAT
AGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAGGAATAGAACCTGACCACATTATTATGAAACATTATGGCTGTTTATGTAATT
TAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAATAATATTTATGTTTACAATGTAACTTTTCAAAATTTACAAATCAGGATTAT
ATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAAATTTGCCAGCGTTAAAGTAGAAAATAACATTTCAGAAGAGCACAATATGCA
TAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATTAAAAACCTTTACTATTGGCTACAAATTTATTGTACCTGATGAAAACATATT
TTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCAGTAATTGTTTTGCACTTTCAAAGATTGTAAATAGTTCATTCAATCAATGGT
ATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCAAATAATTACTTTTTATTTATTTTATTTAGTACGTAATTTTGAAGTACATTT
TTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGGAATTGTATGTATGTATATCTTCTGTAAATAACATCTAGTATCTTCACTAAA

>54347_54347_2_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000338983_RAPGEF4_chr2_173825488_ENST00000397081_length(amino acids)=924AA_BP=92
MSSQPPPPSSRAGPPRPRLLLTPRPGARFCGSIILCHYEMSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE
KETPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLE
DGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKAL
SHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLR
VDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMH
CVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELE
KIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSG
GEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFK
KTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFE
SLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYV

--------------------------------------------------------------
>54347_54347_3_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000338983_RAPGEF4_chr2_173825488_ENST00000397087_length(transcript)=3979nt_BP=354nt
CTTCCTCATTGGCGCCGTGCAGAGAGGCGGAATGTTCAACTCCTAACTGCAGCGGAAACGTGGGAGCCGCGCGGGCCGCTGTCGTCCCAA
CCCCCGCCGCCCTCGTCGCGCGCGGGGCCTCCGCGCCCCCGGCTGCTGCTCACGCCCCGCCCGGGAGCCAGATTTTGTGGAAGTATAATA
CTTTGTCATTATGAGATGTCGTCTCTCGGTGCCTCCTTTGTGCAAATTAAATTTGATGACTTGCAGTTTTTTGAAAACTGCGGTGGAGGA
AGTTTTGGGAGTGTTTATCGAGCCAAATGGATATCACAGGACAAGGAGGTGGCTGTAAAGAAGCTCCTCAAAATAGAGAAAGAGACACCT
CTCATTGAACCTCACGTTCCTCTTCGTCCTGCTAACACCATTACCAAGGTCCCTTCAGAGAAGATCCTCAGAGCTGGAAAAATTTTACGA
AATGCCATTCTCTCTCGAGCACCTCACATGATAAGAGATAGAAAATACCACCTAAAGACATACAGACAATGCTGTGTGGGAACTGAACTG
GTGGACTGGATGATGCAGCAGACACCATGTGTTCACTCCCGGACTCAAGCTGTTGGCATGTGGCAAGTCCTGTTAGAAGATGGTGTTCTC
AACCACGTGGACCAGGAGCACCATTTCCAAGACAAATATTTATTCTATCGATTTCTGGATGATGAGCACGAGGATGCCCCTTTGCCTACT
GAGGAGGAGAAGAAGGAGTGTGATGAGGAGCTCCAGGACACCATGCTGCTGCTGTCACAGATGGGCCCCGACGCCCACATGAGGATGATC
CTTCGCAAACCACCTGGCCAGAGGACTGTGGATGACCTAGAGATTATCTATGAGGAGCTTCTTCATATTAAAGCCTTATCCCATCTTTCT
ACCACAGTGAAACGAGAGTTAGCAGGTGTTCTCATTTTTGAGTCTCACGCCAAAGGAGGGACTGTGTTGTTTAACCAGGGGGAAGAAGGT
ACCTCCTGGTACATTATTCTAAAAGGATCAGTGAATGTAGTCATTTACGGCAAGGGTGTGGTCTGCACCCTGCATGAAGGAGATGACTTC
GGCAAGTTAGCACTAGTGAATGATGCCCCACGAGCTGCCTCTATCGTCTTACGAGAAGATAACTGCCATTTCTTAAGAGTAGACAAGGAG
GATTTCAACCGGATCCTAAGGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCA
GCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCAT
TTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATG
CCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTC
AACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTC
CTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAG
CAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGC
CAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCG
GTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTG
GTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTG
ACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACA
ATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCA
AACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTT
CAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGT
AACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCAAGTTCAAGAAGTTCTATGCGGAGTTTGAAAGTTTAATGGAC
CCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAACCTCCTCTCATCCCCTTCATGCCTTTGCTCATTAAAGATATG
ACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACTTTGAAAAAATGCGCATGATTGCAAATACGGCCAGAACAGTG
AGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAAT
GTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTT
TGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACAC
ATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAG
CTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACGTGAAGAG
TTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAGTGTTTATGGGATGAGATGTGCTACAAATGGG
ATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTGGAGCCTGGGGTTTCGGGAAGGTGTTGAGGAATCTATAGAAGTCCAAATTAT
AGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAGGAATAGAACCTGACCACATTATTATGAAACATTATGGCTGTTTATGTAATT
TAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAATAATATTTATGTTTACAATGTAACTTTTCAAAATTTACAAATCAGGATTAT
ATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAAATTTGCCAGCGTTAAAGTAGAAAATAACATTTCAGAAGAGCACAATATGCA
TAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATTAAAAACCTTTACTATTGGCTACAAATTTATTGTACCTGATGAAAACATATT
TTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCAGTAATTGTTTTGCACTTTCAAAGATTGTAAATAGTTCATTCAATCAATGGT
ATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCAAATAATTACTTTTTATTTATTTTATTTAGTACGTAATTTTGAAGTACATTT
TTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGGAATTGTATGTATGTATATCTTCTGTAAATAACATCTAGTATCTTCACTAAA

>54347_54347_3_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000338983_RAPGEF4_chr2_173825488_ENST00000397087_length(amino acids)=924AA_BP=92
MSSQPPPPSSRAGPPRPRLLLTPRPGARFCGSIILCHYEMSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE
KETPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLE
DGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKAL
SHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLR
VDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMH
CVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELE
KIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSG
GEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFK
KTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFE
SLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYV

--------------------------------------------------------------
>54347_54347_4_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000338983_RAPGEF4_chr2_173825488_ENST00000409036_length(transcript)=3775nt_BP=354nt
CTTCCTCATTGGCGCCGTGCAGAGAGGCGGAATGTTCAACTCCTAACTGCAGCGGAAACGTGGGAGCCGCGCGGGCCGCTGTCGTCCCAA
CCCCCGCCGCCCTCGTCGCGCGCGGGGCCTCCGCGCCCCCGGCTGCTGCTCACGCCCCGCCCGGGAGCCAGATTTTGTGGAAGTATAATA
CTTTGTCATTATGAGATGTCGTCTCTCGGTGCCTCCTTTGTGCAAATTAAATTTGATGACTTGCAGTTTTTTGAAAACTGCGGTGGAGGA
AGTTTTGGGAGTGTTTATCGAGCCAAATGGATATCACAGGACAAGGAGGTGGCTGTAAAGAAGCTCCTCAAAATAGAGAAAGAGACACCT
CTCATTGAACCTCACGTTCCTCTTCGTCCTGCTAACACCATTACCAAGGTCCCTTCAGAGAAGATCCTCAGAGCTGGAAAAATTTTACGA
AATGCCATTCTCTCTCGAGCACCTCACATGATAAGAGATAGAAAATACCACCTAAAGACATACAGACAATGCTGTGTGGGAACTGAACTG
GTGGACTGGATGATGCAGCAGACACCATGTGTTCACTCCCGGACTCAAGCTGTTGGCATGTGGCAAGTCCTGTTAGAAGATGGTGTTCTC
AACCACGTGGACCAGGAGCACCATTTCCAAGACAAATATTTATTCTATCGATTTCTGGATGATGAGCACGAGGATGCCCCTTTGCCTACT
GAGGAGGAGAAGAAGGAGTGTGATGAGGAGCTCCAGGACACCATGCTGCTGCTGTCACAGATGGGCCCCGACGCCCACATGAGGATGATC
CTTCGCAAACCACCTGGCCAGAGGACTGTGGATGACCTAGAGATTATCTATGAGGAGCTTCTTCATATTAAAGCCTTATCCCATCTTTCT
ACCACAGTGAAACGAGAGTTAGCAGGTGTTCTCATTTTTGAGTCTCACGCCAAAGGAGGGACTGTGTTGTTTAACCAGGGGGAAGAAGGT
ACCTCCTGGTACATTATTCTAAAAGGATCAGTGAATGTAGTCATTTACGGCAAGGGTGTGGTCTGCACCCTGCATGAAGGAGATGACTTC
GGCAAGTTAGCACTAGTGAATGATGCCCCACGAGCTGCCTCTATCGTCTTACGAGAAGATAACTGCCATTTCTTAAGAGTAGACAAGGAG
GATTTCAACCGGATCCTAAGGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCA
GCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCAT
TTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATG
CCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTC
AACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTC
CTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAG
CAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGC
CAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCG
GTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTG
GTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTG
ACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACA
ATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCA
AACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTT
CAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGT
AACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTC
AATCCTGATGCAGCTCAAGCTAATAAGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTA
TCACAGATGTCACACAGATTAGAGCCTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAA
AAATGCCATTTATGCTACTACTGACTGTATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCA
TTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCT
ACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAG
AGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAGTGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAAATTTTAACT
CAACATCTTGATTTGGAGCCTGGGGTTTCGGGAAGGTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCCATCTTCATT
GTCTTACCTCTGAAGGAATAGAACCTGACCACATTATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTCTGTAATTTC
TGAATGTATATAGAATAATATTTATGTTTACAATGTAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCCACTAAGAAA
TGCCAAGATTCTTAAATTTGCCAGCGTTAAAGTAGAAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAAAATTGAAAT
ATTTTCCTGGGCATTAAAAACCTTTACTATTGGCTACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATGTTATTACAA
ATATCTTAATTTTCAGTAATTGTTTTGCACTTTCAAAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATTTGCTACATA
ATAGATACTGTGCCAAATAATTACTTTTTATTTATTTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACAATTAGACTA

>54347_54347_4_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000338983_RAPGEF4_chr2_173825488_ENST00000409036_length(amino acids)=856AA_BP=92
MSSQPPPPSSRAGPPRPRLLLTPRPGARFCGSIILCHYEMSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE
KETPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLE
DGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKAL
SHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLR
VDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMH
CVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELE
KIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSG
GEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFK
KTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWERMIANTARTVRYYR

--------------------------------------------------------------
>54347_54347_5_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000375213_RAPGEF4_chr2_173825488_ENST00000264111_length(transcript)=3854nt_BP=237nt
CCTCCGCGCCCCCGGCTGCTGCTCACGCCCCGCCCGGGAGCCAGATTTTGTGGAAGTATAATACTTTGTCATTATGAGATGTCGTCTCTC
GGTGCCTCCTTTGTGCAAATTAAATTTGATGACTTGCAGTTTTTTGAAAACTGCGGTGGAGGAAGTTTTGGGAGTGTTTATCGAGCCAAA
TGGATATCACAGGACAAGGAGGTGGCTGTAAAGAAGCTCCTCAAAATAGAGAAAGAGACACCTCTCATTGAACCTCACGTTCCTCTTCGT
CCTGCTAACACCATTACCAAGGTCCCTTCAGAGAAGATCCTCAGAGCTGGAAAAATTTTACGAAATGCCATTCTCTCTCGAGCACCTCAC
ATGATAAGAGATAGAAAATACCACCTAAAGACATACAGACAATGCTGTGTGGGAACTGAACTGGTGGACTGGATGATGCAGCAGACACCA
TGTGTTCACTCCCGGACTCAAGCTGTTGGCATGTGGCAAGTCCTGTTAGAAGATGGTGTTCTCAACCACGTGGACCAGGAGCACCATTTC
CAAGACAAATATTTATTCTATCGATTTCTGGATGATGAGCACGAGGATGCCCCTTTGCCTACTGAGGAGGAGAAGAAGGAGTGTGATGAG
GAGCTCCAGGACACCATGCTGCTGCTGTCACAGATGGGCCCCGACGCCCACATGAGGATGATCCTTCGCAAACCACCTGGCCAGAGGACT
GTGGATGACCTAGAGATTATCTATGAGGAGCTTCTTCATATTAAAGCCTTATCCCATCTTTCTACCACAGTGAAACGAGAGTTAGCAGGT
GTTCTCATTTTTGAGTCTCACGCCAAAGGAGGGACTGTGTTGTTTAACCAGGGGGAAGAAGGTACCTCCTGGTACATTATTCTAAAAGGA
TCAGTGAATGTAGTCATTTACGGCAAGGGTGTGGTCTGCACCCTGCATGAAGGAGATGACTTCGGCAAGTTAGCACTAGTGAATGATGCC
CCACGAGCTGCCTCTATCGTCTTACGAGAAGATAACTGCCATTTCTTAAGAGTAGACAAGGAGGATTTCAACCGGATCCTAAGGGACGTG
GAGGCGAATACAGTCAGACTTAAAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGA
AACTCACAGCCTCAGCAAAAGTATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCA
ACTTTAAATGAAGCAACAGATTCTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTG
GTGGCCCACTACCACGCACAGCCTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTG
GTTCTACAGTGGGCTGCCATGTATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCA
GATGATGCCCGGATGATTGCTGCCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCA
CAAAAGAAGCACAAGGTTCTTTTGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTT
CTGTTTAAGGTCTATTGCATGGACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCC
GACAAGCTGGGCTCCGGGGAGGGCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTA
TTTACGACGCTCACCATTAATGGACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCA
ACTGTTGGAACAGTGGGAACTTTTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGC
GTGCATGAGCTGGAGCTAATCTATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTT
AATGAAATTCAGTTTTGGGTCGTCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATA
GCAGCCCACTGTAAGGAGTATAAAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTA
ACGTGGGAGAAACTGCCAAGCAAGTTCAAGAAGTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGG
CTGACAGTAGCTAAGCTGGAACCTCCTCTCATCCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACG
TTCATTGACAATCTAGTAAACTTTGAAAAAATGCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAAT
CCTGATGCAGCTCAAGCTAATAAGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCA
CAGATGTCACACAGATTAGAGCCTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAA
TGCCATTTATGCTACTACTGACTGTATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTC
AGCTTACCAGCTACCTAGCAAGAGAAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACC
CTGTTTCATTTCCACTTGTGCCATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGA
ACTAGCAAGCCCCTGACATTTTTTTCTAAGAGTGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAAATTTTAACTCAA
CATCTTGATTTGGAGCCTGGGGTTTCGGGAAGGTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCCATCTTCATTGTC
TTACCTCTGAAGGAATAGAACCTGACCACATTATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTCTGTAATTTCTGA
ATGTATATAGAATAATATTTATGTTTACAATGTAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCCACTAAGAAATGC
CAAGATTCTTAAATTTGCCAGCGTTAAAGTAGAAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAAAATTGAAATATT
TTCCTGGGCATTAAAAACCTTTACTATTGGCTACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATGTTATTACAAATA
TCTTAATTTTCAGTAATTGTTTTGCACTTTCAAAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATTTGCTACATAATA
GATACTGTGCCAAATAATTACTTTTTATTTATTTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACAATTAGACTACAT

>54347_54347_5_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000375213_RAPGEF4_chr2_173825488_ENST00000264111_length(amino acids)=906AA_BP=74
MLLTPRPGARFCGSIILCHYEMSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKETPLIEPHVPLRPANTI
TKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYL
FYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFE
SHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTV
RLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYH
AQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHK
VLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLT
INGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQF
WVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAK
LEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHR

--------------------------------------------------------------
>54347_54347_6_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000375213_RAPGEF4_chr2_173825488_ENST00000397081_length(transcript)=3856nt_BP=237nt
CCTCCGCGCCCCCGGCTGCTGCTCACGCCCCGCCCGGGAGCCAGATTTTGTGGAAGTATAATACTTTGTCATTATGAGATGTCGTCTCTC
GGTGCCTCCTTTGTGCAAATTAAATTTGATGACTTGCAGTTTTTTGAAAACTGCGGTGGAGGAAGTTTTGGGAGTGTTTATCGAGCCAAA
TGGATATCACAGGACAAGGAGGTGGCTGTAAAGAAGCTCCTCAAAATAGAGAAAGAGACACCTCTCATTGAACCTCACGTTCCTCTTCGT
CCTGCTAACACCATTACCAAGGTCCCTTCAGAGAAGATCCTCAGAGCTGGAAAAATTTTACGAAATGCCATTCTCTCTCGAGCACCTCAC
ATGATAAGAGATAGAAAATACCACCTAAAGACATACAGACAATGCTGTGTGGGAACTGAACTGGTGGACTGGATGATGCAGCAGACACCA
TGTGTTCACTCCCGGACTCAAGCTGTTGGCATGTGGCAAGTCCTGTTAGAAGATGGTGTTCTCAACCACGTGGACCAGGAGCACCATTTC
CAAGACAAATATTTATTCTATCGATTTCTGGATGATGAGCACGAGGATGCCCCTTTGCCTACTGAGGAGGAGAAGAAGGAGTGTGATGAG
GAGCTCCAGGACACCATGCTGCTGCTGTCACAGATGGGCCCCGACGCCCACATGAGGATGATCCTTCGCAAACCACCTGGCCAGAGGACT
GTGGATGACCTAGAGATTATCTATGAGGAGCTTCTTCATATTAAAGCCTTATCCCATCTTTCTACCACAGTGAAACGAGAGTTAGCAGGT
GTTCTCATTTTTGAGTCTCACGCCAAAGGAGGGACTGTGTTGTTTAACCAGGGGGAAGAAGGTACCTCCTGGTACATTATTCTAAAAGGA
TCAGTGAATGTAGTCATTTACGGCAAGGGTGTGGTCTGCACCCTGCATGAAGGAGATGACTTCGGCAAGTTAGCACTAGTGAATGATGCC
CCACGAGCTGCCTCTATCGTCTTACGAGAAGATAACTGCCATTTCTTAAGAGTAGACAAGGAGGATTTCAACCGGATCCTAAGGGACGTG
GAGGCGAATACAGTCAGACTTAAAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGA
AACTCACAGCCTCAGCAAAAGTATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCA
ACTTTAAATGAAGCAACAGATTCTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTG
GTGGCCCACTACCACGCACAGCCTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTG
GTTCTACAGTGGGCTGCCATGTATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCA
GATGATGCCCGGATGATTGCTGCCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCA
CAAAAGAAGCACAAGGTTCTTTTGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTT
CTGTTTAAGGTCTATTGCATGGACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCC
GACAAGCTGGGCTCCGGGGAGGGCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTA
TTTACGACGCTCACCATTAATGGACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCA
ACTGTTGGAACAGTGGGAACTTTTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGC
GTGCATGAGCTGGAGCTAATCTATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTT
AATGAAATTCAGTTTTGGGTCGTCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATA
GCAGCCCACTGTAAGGAGTATAAAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTA
ACGTGGGAGAAACTGCCAAGCAAGTTCAAGAAGTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGG
CTGACAGTAGCTAAGCTGGAACCTCCTCTCATCCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACG
TTCATTGACAATCTAGTAAACTTTGAAAAAATGCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAAT
CCTGATGCAGCTCAAGCTAATAAGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCA
CAGATGTCACACAGATTAGAGCCTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAA
TGCCATTTATGCTACTACTGACTGTATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTC
AGCTTACCAGCTACCTAGCAAGAGAAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACC
CTGTTTCATTTCCACTTGTGCCATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGA
ACTAGCAAGCCCCTGACATTTTTTTCTAAGAGTGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAAATTTTAACTCAA
CATCTTGATTTGGAGCCTGGGGTTTCGGGAAGGTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCCATCTTCATTGTC
TTACCTCTGAAGGAATAGAACCTGACCACATTATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTCTGTAATTTCTGA
ATGTATATAGAATAATATTTATGTTTACAATGTAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCCACTAAGAAATGC
CAAGATTCTTAAATTTGCCAGCGTTAAAGTAGAAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAAAATTGAAATATT
TTCCTGGGCATTAAAAACCTTTACTATTGGCTACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATGTTATTACAAATA
TCTTAATTTTCAGTAATTGTTTTGCACTTTCAAAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATTTGCTACATAATA
GATACTGTGCCAAATAATTACTTTTTATTTATTTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACAATTAGACTACAT

>54347_54347_6_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000375213_RAPGEF4_chr2_173825488_ENST00000397081_length(amino acids)=906AA_BP=74
MLLTPRPGARFCGSIILCHYEMSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKETPLIEPHVPLRPANTI
TKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYL
FYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFE
SHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTV
RLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYH
AQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHK
VLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLT
INGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQF
WVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAK
LEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHR

--------------------------------------------------------------
>54347_54347_7_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000375213_RAPGEF4_chr2_173825488_ENST00000397087_length(transcript)=3862nt_BP=237nt
CCTCCGCGCCCCCGGCTGCTGCTCACGCCCCGCCCGGGAGCCAGATTTTGTGGAAGTATAATACTTTGTCATTATGAGATGTCGTCTCTC
GGTGCCTCCTTTGTGCAAATTAAATTTGATGACTTGCAGTTTTTTGAAAACTGCGGTGGAGGAAGTTTTGGGAGTGTTTATCGAGCCAAA
TGGATATCACAGGACAAGGAGGTGGCTGTAAAGAAGCTCCTCAAAATAGAGAAAGAGACACCTCTCATTGAACCTCACGTTCCTCTTCGT
CCTGCTAACACCATTACCAAGGTCCCTTCAGAGAAGATCCTCAGAGCTGGAAAAATTTTACGAAATGCCATTCTCTCTCGAGCACCTCAC
ATGATAAGAGATAGAAAATACCACCTAAAGACATACAGACAATGCTGTGTGGGAACTGAACTGGTGGACTGGATGATGCAGCAGACACCA
TGTGTTCACTCCCGGACTCAAGCTGTTGGCATGTGGCAAGTCCTGTTAGAAGATGGTGTTCTCAACCACGTGGACCAGGAGCACCATTTC
CAAGACAAATATTTATTCTATCGATTTCTGGATGATGAGCACGAGGATGCCCCTTTGCCTACTGAGGAGGAGAAGAAGGAGTGTGATGAG
GAGCTCCAGGACACCATGCTGCTGCTGTCACAGATGGGCCCCGACGCCCACATGAGGATGATCCTTCGCAAACCACCTGGCCAGAGGACT
GTGGATGACCTAGAGATTATCTATGAGGAGCTTCTTCATATTAAAGCCTTATCCCATCTTTCTACCACAGTGAAACGAGAGTTAGCAGGT
GTTCTCATTTTTGAGTCTCACGCCAAAGGAGGGACTGTGTTGTTTAACCAGGGGGAAGAAGGTACCTCCTGGTACATTATTCTAAAAGGA
TCAGTGAATGTAGTCATTTACGGCAAGGGTGTGGTCTGCACCCTGCATGAAGGAGATGACTTCGGCAAGTTAGCACTAGTGAATGATGCC
CCACGAGCTGCCTCTATCGTCTTACGAGAAGATAACTGCCATTTCTTAAGAGTAGACAAGGAGGATTTCAACCGGATCCTAAGGGACGTG
GAGGCGAATACAGTCAGACTTAAAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGA
AACTCACAGCCTCAGCAAAAGTATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCA
ACTTTAAATGAAGCAACAGATTCTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTG
GTGGCCCACTACCACGCACAGCCTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTG
GTTCTACAGTGGGCTGCCATGTATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCA
GATGATGCCCGGATGATTGCTGCCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCA
CAAAAGAAGCACAAGGTTCTTTTGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTT
CTGTTTAAGGTCTATTGCATGGACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCC
GACAAGCTGGGCTCCGGGGAGGGCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTA
TTTACGACGCTCACCATTAATGGACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCA
ACTGTTGGAACAGTGGGAACTTTTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGC
GTGCATGAGCTGGAGCTAATCTATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTT
AATGAAATTCAGTTTTGGGTCGTCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATA
GCAGCCCACTGTAAGGAGTATAAAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTA
ACGTGGGAGAAACTGCCAAGCAAGTTCAAGAAGTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGG
CTGACAGTAGCTAAGCTGGAACCTCCTCTCATCCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACG
TTCATTGACAATCTAGTAAACTTTGAAAAAATGCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAAT
CCTGATGCAGCTCAAGCTAATAAGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCA
CAGATGTCACACAGATTAGAGCCTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAA
TGCCATTTATGCTACTACTGACTGTATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTC
AGCTTACCAGCTACCTAGCAAGAGAAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACC
CTGTTTCATTTCCACTTGTGCCATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGA
ACTAGCAAGCCCCTGACATTTTTTTCTAAGAGTGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAAATTTTAACTCAA
CATCTTGATTTGGAGCCTGGGGTTTCGGGAAGGTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCCATCTTCATTGTC
TTACCTCTGAAGGAATAGAACCTGACCACATTATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTCTGTAATTTCTGA
ATGTATATAGAATAATATTTATGTTTACAATGTAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCCACTAAGAAATGC
CAAGATTCTTAAATTTGCCAGCGTTAAAGTAGAAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAAAATTGAAATATT
TTCCTGGGCATTAAAAACCTTTACTATTGGCTACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATGTTATTACAAATA
TCTTAATTTTCAGTAATTGTTTTGCACTTTCAAAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATTTGCTACATAATA
GATACTGTGCCAAATAATTACTTTTTATTTATTTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACAATTAGACTACAT

>54347_54347_7_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000375213_RAPGEF4_chr2_173825488_ENST00000397087_length(amino acids)=906AA_BP=74
MLLTPRPGARFCGSIILCHYEMSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKETPLIEPHVPLRPANTI
TKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYL
FYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFE
SHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTV
RLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYH
AQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHK
VLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLT
INGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQF
WVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAK
LEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHR

--------------------------------------------------------------
>54347_54347_8_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000375213_RAPGEF4_chr2_173825488_ENST00000409036_length(transcript)=3658nt_BP=237nt
CCTCCGCGCCCCCGGCTGCTGCTCACGCCCCGCCCGGGAGCCAGATTTTGTGGAAGTATAATACTTTGTCATTATGAGATGTCGTCTCTC
GGTGCCTCCTTTGTGCAAATTAAATTTGATGACTTGCAGTTTTTTGAAAACTGCGGTGGAGGAAGTTTTGGGAGTGTTTATCGAGCCAAA
TGGATATCACAGGACAAGGAGGTGGCTGTAAAGAAGCTCCTCAAAATAGAGAAAGAGACACCTCTCATTGAACCTCACGTTCCTCTTCGT
CCTGCTAACACCATTACCAAGGTCCCTTCAGAGAAGATCCTCAGAGCTGGAAAAATTTTACGAAATGCCATTCTCTCTCGAGCACCTCAC
ATGATAAGAGATAGAAAATACCACCTAAAGACATACAGACAATGCTGTGTGGGAACTGAACTGGTGGACTGGATGATGCAGCAGACACCA
TGTGTTCACTCCCGGACTCAAGCTGTTGGCATGTGGCAAGTCCTGTTAGAAGATGGTGTTCTCAACCACGTGGACCAGGAGCACCATTTC
CAAGACAAATATTTATTCTATCGATTTCTGGATGATGAGCACGAGGATGCCCCTTTGCCTACTGAGGAGGAGAAGAAGGAGTGTGATGAG
GAGCTCCAGGACACCATGCTGCTGCTGTCACAGATGGGCCCCGACGCCCACATGAGGATGATCCTTCGCAAACCACCTGGCCAGAGGACT
GTGGATGACCTAGAGATTATCTATGAGGAGCTTCTTCATATTAAAGCCTTATCCCATCTTTCTACCACAGTGAAACGAGAGTTAGCAGGT
GTTCTCATTTTTGAGTCTCACGCCAAAGGAGGGACTGTGTTGTTTAACCAGGGGGAAGAAGGTACCTCCTGGTACATTATTCTAAAAGGA
TCAGTGAATGTAGTCATTTACGGCAAGGGTGTGGTCTGCACCCTGCATGAAGGAGATGACTTCGGCAAGTTAGCACTAGTGAATGATGCC
CCACGAGCTGCCTCTATCGTCTTACGAGAAGATAACTGCCATTTCTTAAGAGTAGACAAGGAGGATTTCAACCGGATCCTAAGGGACGTG
GAGGCGAATACAGTCAGACTTAAAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGA
AACTCACAGCCTCAGCAAAAGTATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCA
ACTTTAAATGAAGCAACAGATTCTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTG
GTGGCCCACTACCACGCACAGCCTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTG
GTTCTACAGTGGGCTGCCATGTATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCA
GATGATGCCCGGATGATTGCTGCCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCA
CAAAAGAAGCACAAGGTTCTTTTGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTT
CTGTTTAAGGTCTATTGCATGGACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCC
GACAAGCTGGGCTCCGGGGAGGGCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTA
TTTACGACGCTCACCATTAATGGACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCA
ACTGTTGGAACAGTGGGAACTTTTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGC
GTGCATGAGCTGGAGCTAATCTATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTT
AATGAAATTCAGTTTTGGGTCGTCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATA
GCAGCCCACTGTAAGGAGTATAAAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTA
ACGTGGGAGCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAG
AACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGCCT
CGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGACTG
TATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAG
AAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCAT
CTTCTTTGCTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTT
TCTAAGAGTGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTGGAGCCTGGGGTT
TCGGGAAGGTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAGGAATAGAACCTG
ACCACATTATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAATAATATTTATGT
TTACAATGTAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAAATTTGCCAGCGT
TAAAGTAGAAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATTAAAAACCTTTAC
TATTGGCTACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCAGTAATTGTTTTG
CACTTTCAAAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCAAATAATTACTTT
TTATTTATTTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGGAATTGTATGTAT

>54347_54347_8_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000375213_RAPGEF4_chr2_173825488_ENST00000409036_length(amino acids)=838AA_BP=74
MLLTPRPGARFCGSIILCHYEMSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKETPLIEPHVPLRPANTI
TKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYL
FYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFE
SHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTV
RLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYH
AQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHK
VLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLT
INGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQF
WVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWERMIANTARTVRYYRSQPFNPDAAQANKNHQDV

--------------------------------------------------------------
>54347_54347_9_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000409176_RAPGEF4_chr2_173825488_ENST00000264111_length(transcript)=3912nt_BP=295nt
GGTGCCCCCCGGGCGCAGGCCAGGGAGGCCCGAGCGCCTTCCCCACGCCCCGCTCGCCCGCGCGTGTGAGGGGAGGGCGGCCCAGCCGTT
TCGCGCCGGGAGATTTTGTGGAAGTATAATACTTTGTCATTATGAGATGTCGTCTCTCGGTGCCTCCTTTGTGCAAATTAAATTTGATGA
CTTGCAGTTTTTTGAAAACTGCGGTGGAGGAAGTTTTGGGAGTGTTTATCGAGCCAAATGGATATCACAGGACAAGGAGGTGGCTGTAAA
GAAGCTCCTCAAAATAGAGAAAGAGACACCTCTCATTGAACCTCACGTTCCTCTTCGTCCTGCTAACACCATTACCAAGGTCCCTTCAGA
GAAGATCCTCAGAGCTGGAAAAATTTTACGAAATGCCATTCTCTCTCGAGCACCTCACATGATAAGAGATAGAAAATACCACCTAAAGAC
ATACAGACAATGCTGTGTGGGAACTGAACTGGTGGACTGGATGATGCAGCAGACACCATGTGTTCACTCCCGGACTCAAGCTGTTGGCAT
GTGGCAAGTCCTGTTAGAAGATGGTGTTCTCAACCACGTGGACCAGGAGCACCATTTCCAAGACAAATATTTATTCTATCGATTTCTGGA
TGATGAGCACGAGGATGCCCCTTTGCCTACTGAGGAGGAGAAGAAGGAGTGTGATGAGGAGCTCCAGGACACCATGCTGCTGCTGTCACA
GATGGGCCCCGACGCCCACATGAGGATGATCCTTCGCAAACCACCTGGCCAGAGGACTGTGGATGACCTAGAGATTATCTATGAGGAGCT
TCTTCATATTAAAGCCTTATCCCATCTTTCTACCACAGTGAAACGAGAGTTAGCAGGTGTTCTCATTTTTGAGTCTCACGCCAAAGGAGG
GACTGTGTTGTTTAACCAGGGGGAAGAAGGTACCTCCTGGTACATTATTCTAAAAGGATCAGTGAATGTAGTCATTTACGGCAAGGGTGT
GGTCTGCACCCTGCATGAAGGAGATGACTTCGGCAAGTTAGCACTAGTGAATGATGCCCCACGAGCTGCCTCTATCGTCTTACGAGAAGA
TAACTGCCATTTCTTAAGAGTAGACAAGGAGGATTTCAACCGGATCCTAAGGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGA
CCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGAT
GTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAA
TGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGG
TACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCT
CCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGA
GCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTT
CAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTA
CACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCAT
AGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTT
TGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGAT
GAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATT
TGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGAT
CTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAA
TTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCAAGTTCAAGAA
GTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAACCTCCTCTCAT
CCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACTTTGAAAAAAT
GCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCA
GGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACC
ATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCA
CTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATT
ATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTG
CTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAG
TGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTGGAGCCTGGGGTTTCGGGAAG
GTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAGGAATAGAACCTGACCACATT
ATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAATAATATTTATGTTTACAATG
TAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAAATTTGCCAGCGTTAAAGTAG
AAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATTAAAAACCTTTACTATTGGCT
ACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCAGTAATTGTTTTGCACTTTCA
AAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCAAATAATTACTTTTTATTTAT
TTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGGAATTGTATGTATGTATATCT

>54347_54347_9_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000409176_RAPGEF4_chr2_173825488_ENST00000264111_length(amino acids)=885AA_BP=53
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKETPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILS
RAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKK
ECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYI
ILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRA
SNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRR
VIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRG
SDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPE
QEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKK
FIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHE

--------------------------------------------------------------
>54347_54347_10_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000409176_RAPGEF4_chr2_173825488_ENST00000397081_length(transcript)=3914nt_BP=295nt
GGTGCCCCCCGGGCGCAGGCCAGGGAGGCCCGAGCGCCTTCCCCACGCCCCGCTCGCCCGCGCGTGTGAGGGGAGGGCGGCCCAGCCGTT
TCGCGCCGGGAGATTTTGTGGAAGTATAATACTTTGTCATTATGAGATGTCGTCTCTCGGTGCCTCCTTTGTGCAAATTAAATTTGATGA
CTTGCAGTTTTTTGAAAACTGCGGTGGAGGAAGTTTTGGGAGTGTTTATCGAGCCAAATGGATATCACAGGACAAGGAGGTGGCTGTAAA
GAAGCTCCTCAAAATAGAGAAAGAGACACCTCTCATTGAACCTCACGTTCCTCTTCGTCCTGCTAACACCATTACCAAGGTCCCTTCAGA
GAAGATCCTCAGAGCTGGAAAAATTTTACGAAATGCCATTCTCTCTCGAGCACCTCACATGATAAGAGATAGAAAATACCACCTAAAGAC
ATACAGACAATGCTGTGTGGGAACTGAACTGGTGGACTGGATGATGCAGCAGACACCATGTGTTCACTCCCGGACTCAAGCTGTTGGCAT
GTGGCAAGTCCTGTTAGAAGATGGTGTTCTCAACCACGTGGACCAGGAGCACCATTTCCAAGACAAATATTTATTCTATCGATTTCTGGA
TGATGAGCACGAGGATGCCCCTTTGCCTACTGAGGAGGAGAAGAAGGAGTGTGATGAGGAGCTCCAGGACACCATGCTGCTGCTGTCACA
GATGGGCCCCGACGCCCACATGAGGATGATCCTTCGCAAACCACCTGGCCAGAGGACTGTGGATGACCTAGAGATTATCTATGAGGAGCT
TCTTCATATTAAAGCCTTATCCCATCTTTCTACCACAGTGAAACGAGAGTTAGCAGGTGTTCTCATTTTTGAGTCTCACGCCAAAGGAGG
GACTGTGTTGTTTAACCAGGGGGAAGAAGGTACCTCCTGGTACATTATTCTAAAAGGATCAGTGAATGTAGTCATTTACGGCAAGGGTGT
GGTCTGCACCCTGCATGAAGGAGATGACTTCGGCAAGTTAGCACTAGTGAATGATGCCCCACGAGCTGCCTCTATCGTCTTACGAGAAGA
TAACTGCCATTTCTTAAGAGTAGACAAGGAGGATTTCAACCGGATCCTAAGGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGA
CCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGAT
GTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAA
TGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGG
TACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCT
CCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGA
GCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTT
CAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTA
CACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCAT
AGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTT
TGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGAT
GAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATT
TGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGAT
CTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAA
TTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCAAGTTCAAGAA
GTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAACCTCCTCTCAT
CCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACTTTGAAAAAAT
GCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCA
GGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACC
ATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCA
CTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATT
ATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTG
CTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAG
TGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTGGAGCCTGGGGTTTCGGGAAG
GTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAGGAATAGAACCTGACCACATT
ATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAATAATATTTATGTTTACAATG
TAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAAATTTGCCAGCGTTAAAGTAG
AAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATTAAAAACCTTTACTATTGGCT
ACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCAGTAATTGTTTTGCACTTTCA
AAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCAAATAATTACTTTTTATTTAT
TTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGGAATTGTATGTATGTATATCT

>54347_54347_10_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000409176_RAPGEF4_chr2_173825488_ENST00000397081_length(amino acids)=885AA_BP=53
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKETPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILS
RAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKK
ECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYI
ILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRA
SNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRR
VIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRG
SDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPE
QEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKK
FIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHE

--------------------------------------------------------------
>54347_54347_11_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000409176_RAPGEF4_chr2_173825488_ENST00000397087_length(transcript)=3920nt_BP=295nt
GGTGCCCCCCGGGCGCAGGCCAGGGAGGCCCGAGCGCCTTCCCCACGCCCCGCTCGCCCGCGCGTGTGAGGGGAGGGCGGCCCAGCCGTT
TCGCGCCGGGAGATTTTGTGGAAGTATAATACTTTGTCATTATGAGATGTCGTCTCTCGGTGCCTCCTTTGTGCAAATTAAATTTGATGA
CTTGCAGTTTTTTGAAAACTGCGGTGGAGGAAGTTTTGGGAGTGTTTATCGAGCCAAATGGATATCACAGGACAAGGAGGTGGCTGTAAA
GAAGCTCCTCAAAATAGAGAAAGAGACACCTCTCATTGAACCTCACGTTCCTCTTCGTCCTGCTAACACCATTACCAAGGTCCCTTCAGA
GAAGATCCTCAGAGCTGGAAAAATTTTACGAAATGCCATTCTCTCTCGAGCACCTCACATGATAAGAGATAGAAAATACCACCTAAAGAC
ATACAGACAATGCTGTGTGGGAACTGAACTGGTGGACTGGATGATGCAGCAGACACCATGTGTTCACTCCCGGACTCAAGCTGTTGGCAT
GTGGCAAGTCCTGTTAGAAGATGGTGTTCTCAACCACGTGGACCAGGAGCACCATTTCCAAGACAAATATTTATTCTATCGATTTCTGGA
TGATGAGCACGAGGATGCCCCTTTGCCTACTGAGGAGGAGAAGAAGGAGTGTGATGAGGAGCTCCAGGACACCATGCTGCTGCTGTCACA
GATGGGCCCCGACGCCCACATGAGGATGATCCTTCGCAAACCACCTGGCCAGAGGACTGTGGATGACCTAGAGATTATCTATGAGGAGCT
TCTTCATATTAAAGCCTTATCCCATCTTTCTACCACAGTGAAACGAGAGTTAGCAGGTGTTCTCATTTTTGAGTCTCACGCCAAAGGAGG
GACTGTGTTGTTTAACCAGGGGGAAGAAGGTACCTCCTGGTACATTATTCTAAAAGGATCAGTGAATGTAGTCATTTACGGCAAGGGTGT
GGTCTGCACCCTGCATGAAGGAGATGACTTCGGCAAGTTAGCACTAGTGAATGATGCCCCACGAGCTGCCTCTATCGTCTTACGAGAAGA
TAACTGCCATTTCTTAAGAGTAGACAAGGAGGATTTCAACCGGATCCTAAGGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGA
CCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGAT
GTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAA
TGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGG
TACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCT
CCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGA
GCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTT
CAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTA
CACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCAT
AGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTT
TGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGAT
GAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATT
TGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGAT
CTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAA
TTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCAAGTTCAAGAA
GTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAACCTCCTCTCAT
CCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACTTTGAAAAAAT
GCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCA
GGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACC
ATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCA
CTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATT
ATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTG
CTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAG
TGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTGGAGCCTGGGGTTTCGGGAAG
GTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAGGAATAGAACCTGACCACATT
ATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAATAATATTTATGTTTACAATG
TAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAAATTTGCCAGCGTTAAAGTAG
AAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATTAAAAACCTTTACTATTGGCT
ACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCAGTAATTGTTTTGCACTTTCA
AAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCAAATAATTACTTTTTATTTAT
TTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGGAATTGTATGTATGTATATCT

>54347_54347_11_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000409176_RAPGEF4_chr2_173825488_ENST00000397087_length(amino acids)=885AA_BP=53
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKETPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILS
RAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKK
ECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYI
ILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRA
SNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRR
VIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRG
SDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPE
QEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKK
FIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHE

--------------------------------------------------------------
>54347_54347_12_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000409176_RAPGEF4_chr2_173825488_ENST00000409036_length(transcript)=3716nt_BP=295nt
GGTGCCCCCCGGGCGCAGGCCAGGGAGGCCCGAGCGCCTTCCCCACGCCCCGCTCGCCCGCGCGTGTGAGGGGAGGGCGGCCCAGCCGTT
TCGCGCCGGGAGATTTTGTGGAAGTATAATACTTTGTCATTATGAGATGTCGTCTCTCGGTGCCTCCTTTGTGCAAATTAAATTTGATGA
CTTGCAGTTTTTTGAAAACTGCGGTGGAGGAAGTTTTGGGAGTGTTTATCGAGCCAAATGGATATCACAGGACAAGGAGGTGGCTGTAAA
GAAGCTCCTCAAAATAGAGAAAGAGACACCTCTCATTGAACCTCACGTTCCTCTTCGTCCTGCTAACACCATTACCAAGGTCCCTTCAGA
GAAGATCCTCAGAGCTGGAAAAATTTTACGAAATGCCATTCTCTCTCGAGCACCTCACATGATAAGAGATAGAAAATACCACCTAAAGAC
ATACAGACAATGCTGTGTGGGAACTGAACTGGTGGACTGGATGATGCAGCAGACACCATGTGTTCACTCCCGGACTCAAGCTGTTGGCAT
GTGGCAAGTCCTGTTAGAAGATGGTGTTCTCAACCACGTGGACCAGGAGCACCATTTCCAAGACAAATATTTATTCTATCGATTTCTGGA
TGATGAGCACGAGGATGCCCCTTTGCCTACTGAGGAGGAGAAGAAGGAGTGTGATGAGGAGCTCCAGGACACCATGCTGCTGCTGTCACA
GATGGGCCCCGACGCCCACATGAGGATGATCCTTCGCAAACCACCTGGCCAGAGGACTGTGGATGACCTAGAGATTATCTATGAGGAGCT
TCTTCATATTAAAGCCTTATCCCATCTTTCTACCACAGTGAAACGAGAGTTAGCAGGTGTTCTCATTTTTGAGTCTCACGCCAAAGGAGG
GACTGTGTTGTTTAACCAGGGGGAAGAAGGTACCTCCTGGTACATTATTCTAAAAGGATCAGTGAATGTAGTCATTTACGGCAAGGGTGT
GGTCTGCACCCTGCATGAAGGAGATGACTTCGGCAAGTTAGCACTAGTGAATGATGCCCCACGAGCTGCCTCTATCGTCTTACGAGAAGA
TAACTGCCATTTCTTAAGAGTAGACAAGGAGGATTTCAACCGGATCCTAAGGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGA
CCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGAT
GTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAA
TGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGG
TACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCT
CCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGA
GCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTT
CAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTA
CACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCAT
AGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTT
TGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGAT
GAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATT
TGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGAT
CTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAA
TTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGCGCATGATTGCAAATACGGCCAG
AACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCAGGATGTCCGGAGTTATGTACGGCA
ATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACCATAGACATTTCAAATGCCCAAAGC
AACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCACTAGAGAATTCTACAAAACAAGCA
AAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATTATTTGACATGCCTAAAGCTTACAC
ACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACG
TGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAGTGTTTATGGGATGAGATGTGCTAC
AAATGGGATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTGGAGCCTGGGGTTTCGGGAAGGTGTTGAGGAATCTATAGAAGTCC
AAATTATAGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAGGAATAGAACCTGACCACATTATTATGAAACATTATGGCTGTTTA
TGTAATTTAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAATAATATTTATGTTTACAATGTAACTTTTCAAAATTTACAAATCA
GGATTATATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAAATTTGCCAGCGTTAAAGTAGAAAATAACATTTCAGAAGAGCACA
ATATGCATAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATTAAAAACCTTTACTATTGGCTACAAATTTATTGTACCTGATGAAA
ACATATTTTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCAGTAATTGTTTTGCACTTTCAAAGATTGTAAATAGTTCATTCAAT
CAATGGTATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCAAATAATTACTTTTTATTTATTTTATTTAGTACGTAATTTTGAAG
TACATTTTTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGGAATTGTATGTATGTATATCTTCTGTAAATAACATCTAGTATCTT

>54347_54347_12_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000409176_RAPGEF4_chr2_173825488_ENST00000409036_length(amino acids)=817AA_BP=53
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKETPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILS
RAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKK
ECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYI
ILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRA
SNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRR
VIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRG
SDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPE
QEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKK
FIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWERMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSH

--------------------------------------------------------------
>54347_54347_13_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000539448_RAPGEF4_chr2_173825488_ENST00000264111_length(transcript)=4046nt_BP=429nt
AGAGAGGCAGCCTTCAGACCTATGTTCCCAGAAATCTCTACGTTTGTGCCTTTCCCAACTAGAGAATTAACTCTTGCGGGGCACAAAACA
GCCTCTATTTCTTTGCGTCCCCAGCGCCTGTTTGTTGAAGACTGAGTTGAAGGAGTAGCAGGTGGTGTTAATTTGTCAAAAAGATGAGTT
AAGGTGCTGGGGGCGAGGGGGAACACCCCCACGGCCCTCCCCCCACAGCAAGGCAGATTTTGTGGAAGTATAATACTTTGTCATTATGAG
ATGTCGTCTCTCGGTGCCTCCTTTGTGCAAATTAAATTTGATGACTTGCAGTTTTTTGAAAACTGCGGTGGAGGAAGTTTTGGGAGTGTT
TATCGAGCCAAATGGATATCACAGGACAAGGAGGTGGCTGTAAAGAAGCTCCTCAAAATAGAGAAAGAGACACCTCTCATTGAACCTCAC
GTTCCTCTTCGTCCTGCTAACACCATTACCAAGGTCCCTTCAGAGAAGATCCTCAGAGCTGGAAAAATTTTACGAAATGCCATTCTCTCT
CGAGCACCTCACATGATAAGAGATAGAAAATACCACCTAAAGACATACAGACAATGCTGTGTGGGAACTGAACTGGTGGACTGGATGATG
CAGCAGACACCATGTGTTCACTCCCGGACTCAAGCTGTTGGCATGTGGCAAGTCCTGTTAGAAGATGGTGTTCTCAACCACGTGGACCAG
GAGCACCATTTCCAAGACAAATATTTATTCTATCGATTTCTGGATGATGAGCACGAGGATGCCCCTTTGCCTACTGAGGAGGAGAAGAAG
GAGTGTGATGAGGAGCTCCAGGACACCATGCTGCTGCTGTCACAGATGGGCCCCGACGCCCACATGAGGATGATCCTTCGCAAACCACCT
GGCCAGAGGACTGTGGATGACCTAGAGATTATCTATGAGGAGCTTCTTCATATTAAAGCCTTATCCCATCTTTCTACCACAGTGAAACGA
GAGTTAGCAGGTGTTCTCATTTTTGAGTCTCACGCCAAAGGAGGGACTGTGTTGTTTAACCAGGGGGAAGAAGGTACCTCCTGGTACATT
ATTCTAAAAGGATCAGTGAATGTAGTCATTTACGGCAAGGGTGTGGTCTGCACCCTGCATGAAGGAGATGACTTCGGCAAGTTAGCACTA
GTGAATGATGCCCCACGAGCTGCCTCTATCGTCTTACGAGAAGATAACTGCCATTTCTTAAGAGTAGACAAGGAGGATTTCAACCGGATC
CTAAGGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCT
TCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATA
CGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTT
TGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGA
GTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTAT
GTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGAT
GCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGC
TCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATC
AGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAAT
GATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAA
CAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAA
CTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTC
CTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAA
TTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGC
CGCTTGGCACTAACGTGGGAGAAACTGCCAAGCAAGTTCAAGAAGTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCAC
AGGGCCTACAGGCTGACAGTAGCTAAGCTGGAACCTCCTCTCATCCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAG
GGGAACAAGACGTTCATTGACAATCTAGTAAACTTTGAAAAAATGCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGC
CAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAG
AGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACA
ATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTC
AGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAG
TTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGC
CTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAGTGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAA
ATTTTAACTCAACATCTTGATTTGGAGCCTGGGGTTTCGGGAAGGTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCC
ATCTTCATTGTCTTACCTCTGAAGGAATAGAACCTGACCACATTATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTC
TGTAATTTCTGAATGTATATAGAATAATATTTATGTTTACAATGTAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCC
ACTAAGAAATGCCAAGATTCTTAAATTTGCCAGCGTTAAAGTAGAAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAA
AATTGAAATATTTTCCTGGGCATTAAAAACCTTTACTATTGGCTACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATG
TTATTACAAATATCTTAATTTTCAGTAATTGTTTTGCACTTTCAAAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATT
TGCTACATAATAGATACTGTGCCAAATAATTACTTTTTATTTATTTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACA

>54347_54347_13_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000539448_RAPGEF4_chr2_173825488_ENST00000264111_length(amino acids)=913AA_BP=81
MGARGNTPTALPPQQGRFCGSIILCHYEMSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKETPLIEPHVP
LRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEH
HFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKREL
AGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILR
DVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCP
ALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAK
APQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDV
SVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLR
RFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRA
YRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRT

--------------------------------------------------------------
>54347_54347_14_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000539448_RAPGEF4_chr2_173825488_ENST00000397081_length(transcript)=4048nt_BP=429nt
AGAGAGGCAGCCTTCAGACCTATGTTCCCAGAAATCTCTACGTTTGTGCCTTTCCCAACTAGAGAATTAACTCTTGCGGGGCACAAAACA
GCCTCTATTTCTTTGCGTCCCCAGCGCCTGTTTGTTGAAGACTGAGTTGAAGGAGTAGCAGGTGGTGTTAATTTGTCAAAAAGATGAGTT
AAGGTGCTGGGGGCGAGGGGGAACACCCCCACGGCCCTCCCCCCACAGCAAGGCAGATTTTGTGGAAGTATAATACTTTGTCATTATGAG
ATGTCGTCTCTCGGTGCCTCCTTTGTGCAAATTAAATTTGATGACTTGCAGTTTTTTGAAAACTGCGGTGGAGGAAGTTTTGGGAGTGTT
TATCGAGCCAAATGGATATCACAGGACAAGGAGGTGGCTGTAAAGAAGCTCCTCAAAATAGAGAAAGAGACACCTCTCATTGAACCTCAC
GTTCCTCTTCGTCCTGCTAACACCATTACCAAGGTCCCTTCAGAGAAGATCCTCAGAGCTGGAAAAATTTTACGAAATGCCATTCTCTCT
CGAGCACCTCACATGATAAGAGATAGAAAATACCACCTAAAGACATACAGACAATGCTGTGTGGGAACTGAACTGGTGGACTGGATGATG
CAGCAGACACCATGTGTTCACTCCCGGACTCAAGCTGTTGGCATGTGGCAAGTCCTGTTAGAAGATGGTGTTCTCAACCACGTGGACCAG
GAGCACCATTTCCAAGACAAATATTTATTCTATCGATTTCTGGATGATGAGCACGAGGATGCCCCTTTGCCTACTGAGGAGGAGAAGAAG
GAGTGTGATGAGGAGCTCCAGGACACCATGCTGCTGCTGTCACAGATGGGCCCCGACGCCCACATGAGGATGATCCTTCGCAAACCACCT
GGCCAGAGGACTGTGGATGACCTAGAGATTATCTATGAGGAGCTTCTTCATATTAAAGCCTTATCCCATCTTTCTACCACAGTGAAACGA
GAGTTAGCAGGTGTTCTCATTTTTGAGTCTCACGCCAAAGGAGGGACTGTGTTGTTTAACCAGGGGGAAGAAGGTACCTCCTGGTACATT
ATTCTAAAAGGATCAGTGAATGTAGTCATTTACGGCAAGGGTGTGGTCTGCACCCTGCATGAAGGAGATGACTTCGGCAAGTTAGCACTA
GTGAATGATGCCCCACGAGCTGCCTCTATCGTCTTACGAGAAGATAACTGCCATTTCTTAAGAGTAGACAAGGAGGATTTCAACCGGATC
CTAAGGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCT
TCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATA
CGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTT
TGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGA
GTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTAT
GTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGAT
GCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGC
TCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATC
AGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAAT
GATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAA
CAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAA
CTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTC
CTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAA
TTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGC
CGCTTGGCACTAACGTGGGAGAAACTGCCAAGCAAGTTCAAGAAGTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCAC
AGGGCCTACAGGCTGACAGTAGCTAAGCTGGAACCTCCTCTCATCCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAG
GGGAACAAGACGTTCATTGACAATCTAGTAAACTTTGAAAAAATGCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGC
CAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAG
AGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACA
ATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTC
AGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAG
TTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGC
CTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAGTGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAA
ATTTTAACTCAACATCTTGATTTGGAGCCTGGGGTTTCGGGAAGGTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCC
ATCTTCATTGTCTTACCTCTGAAGGAATAGAACCTGACCACATTATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTC
TGTAATTTCTGAATGTATATAGAATAATATTTATGTTTACAATGTAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCC
ACTAAGAAATGCCAAGATTCTTAAATTTGCCAGCGTTAAAGTAGAAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAA
AATTGAAATATTTTCCTGGGCATTAAAAACCTTTACTATTGGCTACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATG
TTATTACAAATATCTTAATTTTCAGTAATTGTTTTGCACTTTCAAAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATT
TGCTACATAATAGATACTGTGCCAAATAATTACTTTTTATTTATTTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACA

>54347_54347_14_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000539448_RAPGEF4_chr2_173825488_ENST00000397081_length(amino acids)=913AA_BP=81
MGARGNTPTALPPQQGRFCGSIILCHYEMSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKETPLIEPHVP
LRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEH
HFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKREL
AGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILR
DVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCP
ALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAK
APQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDV
SVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLR
RFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRA
YRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRT

--------------------------------------------------------------
>54347_54347_15_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000539448_RAPGEF4_chr2_173825488_ENST00000397087_length(transcript)=4054nt_BP=429nt
AGAGAGGCAGCCTTCAGACCTATGTTCCCAGAAATCTCTACGTTTGTGCCTTTCCCAACTAGAGAATTAACTCTTGCGGGGCACAAAACA
GCCTCTATTTCTTTGCGTCCCCAGCGCCTGTTTGTTGAAGACTGAGTTGAAGGAGTAGCAGGTGGTGTTAATTTGTCAAAAAGATGAGTT
AAGGTGCTGGGGGCGAGGGGGAACACCCCCACGGCCCTCCCCCCACAGCAAGGCAGATTTTGTGGAAGTATAATACTTTGTCATTATGAG
ATGTCGTCTCTCGGTGCCTCCTTTGTGCAAATTAAATTTGATGACTTGCAGTTTTTTGAAAACTGCGGTGGAGGAAGTTTTGGGAGTGTT
TATCGAGCCAAATGGATATCACAGGACAAGGAGGTGGCTGTAAAGAAGCTCCTCAAAATAGAGAAAGAGACACCTCTCATTGAACCTCAC
GTTCCTCTTCGTCCTGCTAACACCATTACCAAGGTCCCTTCAGAGAAGATCCTCAGAGCTGGAAAAATTTTACGAAATGCCATTCTCTCT
CGAGCACCTCACATGATAAGAGATAGAAAATACCACCTAAAGACATACAGACAATGCTGTGTGGGAACTGAACTGGTGGACTGGATGATG
CAGCAGACACCATGTGTTCACTCCCGGACTCAAGCTGTTGGCATGTGGCAAGTCCTGTTAGAAGATGGTGTTCTCAACCACGTGGACCAG
GAGCACCATTTCCAAGACAAATATTTATTCTATCGATTTCTGGATGATGAGCACGAGGATGCCCCTTTGCCTACTGAGGAGGAGAAGAAG
GAGTGTGATGAGGAGCTCCAGGACACCATGCTGCTGCTGTCACAGATGGGCCCCGACGCCCACATGAGGATGATCCTTCGCAAACCACCT
GGCCAGAGGACTGTGGATGACCTAGAGATTATCTATGAGGAGCTTCTTCATATTAAAGCCTTATCCCATCTTTCTACCACAGTGAAACGA
GAGTTAGCAGGTGTTCTCATTTTTGAGTCTCACGCCAAAGGAGGGACTGTGTTGTTTAACCAGGGGGAAGAAGGTACCTCCTGGTACATT
ATTCTAAAAGGATCAGTGAATGTAGTCATTTACGGCAAGGGTGTGGTCTGCACCCTGCATGAAGGAGATGACTTCGGCAAGTTAGCACTA
GTGAATGATGCCCCACGAGCTGCCTCTATCGTCTTACGAGAAGATAACTGCCATTTCTTAAGAGTAGACAAGGAGGATTTCAACCGGATC
CTAAGGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCT
TCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATA
CGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTT
TGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGA
GTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTAT
GTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGAT
GCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGC
TCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATC
AGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAAT
GATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAA
CAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAA
CTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTC
CTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAA
TTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGC
CGCTTGGCACTAACGTGGGAGAAACTGCCAAGCAAGTTCAAGAAGTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCAC
AGGGCCTACAGGCTGACAGTAGCTAAGCTGGAACCTCCTCTCATCCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAG
GGGAACAAGACGTTCATTGACAATCTAGTAAACTTTGAAAAAATGCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGC
CAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAG
AGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACA
ATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTC
AGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAG
TTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGC
CTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAGTGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAA
ATTTTAACTCAACATCTTGATTTGGAGCCTGGGGTTTCGGGAAGGTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCC
ATCTTCATTGTCTTACCTCTGAAGGAATAGAACCTGACCACATTATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTC
TGTAATTTCTGAATGTATATAGAATAATATTTATGTTTACAATGTAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCC
ACTAAGAAATGCCAAGATTCTTAAATTTGCCAGCGTTAAAGTAGAAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAA
AATTGAAATATTTTCCTGGGCATTAAAAACCTTTACTATTGGCTACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATG
TTATTACAAATATCTTAATTTTCAGTAATTGTTTTGCACTTTCAAAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATT
TGCTACATAATAGATACTGTGCCAAATAATTACTTTTTATTTATTTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACA
ATTAGACTACATTTAATGTGTAGGAATTGTATGTATGTATATCTTCTGTAAATAACATCTAGTATCTTCACTAAATATAATTGTCGACAA

>54347_54347_15_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000539448_RAPGEF4_chr2_173825488_ENST00000397087_length(amino acids)=913AA_BP=81
MGARGNTPTALPPQQGRFCGSIILCHYEMSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKETPLIEPHVP
LRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEH
HFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKREL
AGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILR
DVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCP
ALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAK
APQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDV
SVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLR
RFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRA
YRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRT

--------------------------------------------------------------
>54347_54347_16_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000539448_RAPGEF4_chr2_173825488_ENST00000409036_length(transcript)=3850nt_BP=429nt
AGAGAGGCAGCCTTCAGACCTATGTTCCCAGAAATCTCTACGTTTGTGCCTTTCCCAACTAGAGAATTAACTCTTGCGGGGCACAAAACA
GCCTCTATTTCTTTGCGTCCCCAGCGCCTGTTTGTTGAAGACTGAGTTGAAGGAGTAGCAGGTGGTGTTAATTTGTCAAAAAGATGAGTT
AAGGTGCTGGGGGCGAGGGGGAACACCCCCACGGCCCTCCCCCCACAGCAAGGCAGATTTTGTGGAAGTATAATACTTTGTCATTATGAG
ATGTCGTCTCTCGGTGCCTCCTTTGTGCAAATTAAATTTGATGACTTGCAGTTTTTTGAAAACTGCGGTGGAGGAAGTTTTGGGAGTGTT
TATCGAGCCAAATGGATATCACAGGACAAGGAGGTGGCTGTAAAGAAGCTCCTCAAAATAGAGAAAGAGACACCTCTCATTGAACCTCAC
GTTCCTCTTCGTCCTGCTAACACCATTACCAAGGTCCCTTCAGAGAAGATCCTCAGAGCTGGAAAAATTTTACGAAATGCCATTCTCTCT
CGAGCACCTCACATGATAAGAGATAGAAAATACCACCTAAAGACATACAGACAATGCTGTGTGGGAACTGAACTGGTGGACTGGATGATG
CAGCAGACACCATGTGTTCACTCCCGGACTCAAGCTGTTGGCATGTGGCAAGTCCTGTTAGAAGATGGTGTTCTCAACCACGTGGACCAG
GAGCACCATTTCCAAGACAAATATTTATTCTATCGATTTCTGGATGATGAGCACGAGGATGCCCCTTTGCCTACTGAGGAGGAGAAGAAG
GAGTGTGATGAGGAGCTCCAGGACACCATGCTGCTGCTGTCACAGATGGGCCCCGACGCCCACATGAGGATGATCCTTCGCAAACCACCT
GGCCAGAGGACTGTGGATGACCTAGAGATTATCTATGAGGAGCTTCTTCATATTAAAGCCTTATCCCATCTTTCTACCACAGTGAAACGA
GAGTTAGCAGGTGTTCTCATTTTTGAGTCTCACGCCAAAGGAGGGACTGTGTTGTTTAACCAGGGGGAAGAAGGTACCTCCTGGTACATT
ATTCTAAAAGGATCAGTGAATGTAGTCATTTACGGCAAGGGTGTGGTCTGCACCCTGCATGAAGGAGATGACTTCGGCAAGTTAGCACTA
GTGAATGATGCCCCACGAGCTGCCTCTATCGTCTTACGAGAAGATAACTGCCATTTCTTAAGAGTAGACAAGGAGGATTTCAACCGGATC
CTAAGGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCT
TCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATA
CGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTT
TGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGA
GTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTAT
GTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGAT
GCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGC
TCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATC
AGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAAT
GATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAA
CAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAA
CTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTC
CTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAA
TTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGC
CGCTTGGCACTAACGTGGGAGCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCT
CAAGCTAATAAGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACAC
AGATTAGAGCCTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGC
TACTACTGACTGTATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCT
ACCTAGCAAGAGAAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTC
CACTTGTGCCATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCC
CTGACATTTTTTTCTAAGAGTGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTG
GAGCCTGGGGTTTCGGGAAGGTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAG
GAATAGAACCTGACCACATTATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAA
TAATATTTATGTTTACAATGTAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAA
ATTTGCCAGCGTTAAAGTAGAAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATT
AAAAACCTTTACTATTGGCTACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCA
GTAATTGTTTTGCACTTTCAAAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCA
AATAATTACTTTTTATTTATTTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGG

>54347_54347_16_MLTK-RAPGEF4_MLTK_chr2_173955918_ENST00000539448_RAPGEF4_chr2_173825488_ENST00000409036_length(amino acids)=845AA_BP=81
MGARGNTPTALPPQQGRFCGSIILCHYEMSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKETPLIEPHVP
LRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEH
HFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKREL
AGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILR
DVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCP
ALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAK
APQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDV
SVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLR
RFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWERMIANTARTVRYYRSQPFNPDAAQA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MLTK-RAPGEF4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MLTK-RAPGEF4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MLTK-RAPGEF4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource