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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MLTK-SP3 (FusionGDB2 ID:54348)

Fusion Gene Summary for MLTK-SP3

check button Fusion gene summary
Fusion gene informationFusion gene name: MLTK-SP3
Fusion gene ID: 54348
HgeneTgene
Gene symbol

MLTK

SP3

Gene ID

51776

6670

Gene namemitogen-activated protein kinase kinase kinase 20Sp3 transcription factor
SynonymsAZK|CNM6|MLK7|MLT|MLTK|MLTKalpha|MLTKbeta|MRK|SFMMP|ZAK|mlklak|pkSPR2
Cytomap

2q31.1

2q31.1

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase 20HCCS-4MLK-like mitogen-activated protein triple kinaseZAK1 homolog, leucine zipper and sterile-alpha motif kinasehuman cervical cancer suppressor gene 4 proteinmitogen-activated protein kinase kinase ktranscription factor Sp3GC-binding transcription factor Sp3specificity protein 3
Modification date2020031320200313
UniProtAcc.

Q02447

Ensembl transtripts involved in fusion geneENST00000338983, ENST00000375213, 
ENST00000409176, ENST00000539448, 
ENST00000431503, ENST00000480606, 
ENST00000483084, ENST00000310015, 
ENST00000455789, ENST00000418194, 
Fusion gene scores* DoF score4 X 2 X 3=246 X 5 X 4=120
# samples 46
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MLTK [Title/Abstract] AND SP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMLTK(173955918)-SP3(174774985), # samples:1
Anticipated loss of major functional domain due to fusion event.MLTK-SP3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMLTK

GO:0006468

protein phosphorylation

11836244

HgeneMLTK

GO:0007093

mitotic cell cycle checkpoint

15342622

HgeneMLTK

GO:0007257

activation of JUN kinase activity

11836244

HgeneMLTK

GO:0043065

positive regulation of apoptotic process

10924358

HgeneMLTK

GO:0051403

stress-activated MAPK cascade

11836244

HgeneMLTK

GO:0071480

cellular response to gamma radiation

11836244

TgeneSP3

GO:0006355

regulation of transcription, DNA-templated

12560508

TgeneSP3

GO:0045893

positive regulation of transcription, DNA-templated

12771217


check buttonFusion gene breakpoints across MLTK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8372-01AMLTKchr2

173955918

+SP3chr2

174774985

-


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Fusion Gene ORF analysis for MLTK-SP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000338983ENST00000483084MLTKchr2

173955918

+SP3chr2

174774985

-
5CDS-intronENST00000375213ENST00000483084MLTKchr2

173955918

+SP3chr2

174774985

-
5CDS-intronENST00000409176ENST00000483084MLTKchr2

173955918

+SP3chr2

174774985

-
5CDS-intronENST00000539448ENST00000483084MLTKchr2

173955918

+SP3chr2

174774985

-
Frame-shiftENST00000338983ENST00000310015MLTKchr2

173955918

+SP3chr2

174774985

-
Frame-shiftENST00000338983ENST00000455789MLTKchr2

173955918

+SP3chr2

174774985

-
Frame-shiftENST00000375213ENST00000310015MLTKchr2

173955918

+SP3chr2

174774985

-
Frame-shiftENST00000375213ENST00000455789MLTKchr2

173955918

+SP3chr2

174774985

-
Frame-shiftENST00000409176ENST00000310015MLTKchr2

173955918

+SP3chr2

174774985

-
Frame-shiftENST00000409176ENST00000455789MLTKchr2

173955918

+SP3chr2

174774985

-
Frame-shiftENST00000539448ENST00000310015MLTKchr2

173955918

+SP3chr2

174774985

-
Frame-shiftENST00000539448ENST00000455789MLTKchr2

173955918

+SP3chr2

174774985

-
In-frameENST00000338983ENST00000418194MLTKchr2

173955918

+SP3chr2

174774985

-
In-frameENST00000375213ENST00000418194MLTKchr2

173955918

+SP3chr2

174774985

-
In-frameENST00000409176ENST00000418194MLTKchr2

173955918

+SP3chr2

174774985

-
In-frameENST00000539448ENST00000418194MLTKchr2

173955918

+SP3chr2

174774985

-
intron-3CDSENST00000431503ENST00000310015MLTKchr2

173955918

+SP3chr2

174774985

-
intron-3CDSENST00000431503ENST00000418194MLTKchr2

173955918

+SP3chr2

174774985

-
intron-3CDSENST00000431503ENST00000455789MLTKchr2

173955918

+SP3chr2

174774985

-
intron-3CDSENST00000480606ENST00000310015MLTKchr2

173955918

+SP3chr2

174774985

-
intron-3CDSENST00000480606ENST00000418194MLTKchr2

173955918

+SP3chr2

174774985

-
intron-3CDSENST00000480606ENST00000455789MLTKchr2

173955918

+SP3chr2

174774985

-
intron-intronENST00000431503ENST00000483084MLTKchr2

173955918

+SP3chr2

174774985

-
intron-intronENST00000480606ENST00000483084MLTKchr2

173955918

+SP3chr2

174774985

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000539448MLTKchr2173955918+ENST00000418194SP3chr2174774985-2157429332745137
ENST00000409176MLTKchr2173955918+ENST00000418194SP3chr2174774985-2023295198611137
ENST00000338983MLTKchr2173955918+ENST00000418194SP3chr2174774985-2082354257670137
ENST00000375213MLTKchr2173955918+ENST00000418194SP3chr2174774985-1965237140553137

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000539448ENST00000418194MLTKchr2173955918+SP3chr2174774985-0.0224434750.9775565
ENST00000409176ENST00000418194MLTKchr2173955918+SP3chr2174774985-0.01565430.98434573
ENST00000338983ENST00000418194MLTKchr2173955918+SP3chr2174774985-0.0159960540.98400396
ENST00000375213ENST00000418194MLTKchr2173955918+SP3chr2174774985-0.0220761170.9779239

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Fusion Genomic Features for MLTK-SP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MLTK-SP3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:173955918/chr2:174774985)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.SP3

Q02447

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMLTKchr2:173955918chr2:174774985ENST00000375213+22022_3053801.0Nucleotide bindingATP
HgeneMLTKchr2:173955918chr2:174774985ENST00000409176+22022_3053801.0Nucleotide bindingATP
TgeneSP3chr2:173955918chr2:174774985ENST0000031001557681_703676782.0Zinc fingerC2H2-type 3
TgeneSP3chr2:173955918chr2:174774985ENST0000045578946621_645623729.0Zinc fingerC2H2-type 1
TgeneSP3chr2:173955918chr2:174774985ENST0000045578946651_675623729.0Zinc fingerC2H2-type 2
TgeneSP3chr2:173955918chr2:174774985ENST0000045578946681_703623729.0Zinc fingerC2H2-type 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMLTKchr2:173955918chr2:174774985ENST00000375213+22016_27753801.0DomainProtein kinase
HgeneMLTKchr2:173955918chr2:174774985ENST00000375213+220339_41053801.0DomainSAM
HgeneMLTKchr2:173955918chr2:174774985ENST00000409176+22016_27753801.0DomainProtein kinase
HgeneMLTKchr2:173955918chr2:174774985ENST00000409176+220339_41053801.0DomainSAM
HgeneMLTKchr2:173955918chr2:174774985ENST00000375213+220287_30853801.0RegionNote=Leucine-zipper
HgeneMLTKchr2:173955918chr2:174774985ENST00000409176+220287_30853801.0RegionNote=Leucine-zipper
TgeneSP3chr2:173955918chr2:174774985ENST000003100155721_31676782.0Compositional biasNote=Poly-Gly
TgeneSP3chr2:173955918chr2:174774985ENST000003100155735_39676782.0Compositional biasNote=Poly-Gln
TgeneSP3chr2:173955918chr2:174774985ENST000003100155744_100676782.0Compositional biasNote=Ala-rich
TgeneSP3chr2:173955918chr2:174774985ENST000004557894621_31623729.0Compositional biasNote=Poly-Gly
TgeneSP3chr2:173955918chr2:174774985ENST000004557894635_39623729.0Compositional biasNote=Poly-Gln
TgeneSP3chr2:173955918chr2:174774985ENST000004557894644_100623729.0Compositional biasNote=Ala-rich
TgeneSP3chr2:173955918chr2:174774985ENST0000031001557461_469676782.0Motif9aaTAD
TgeneSP3chr2:173955918chr2:174774985ENST0000045578946461_469623729.0Motif9aaTAD
TgeneSP3chr2:173955918chr2:174774985ENST0000031001557138_237676782.0RegionNote=Transactivation domain (Gln-rich)
TgeneSP3chr2:173955918chr2:174774985ENST0000031001557350_499676782.0RegionNote=Transactivation domain (Gln-rich)
TgeneSP3chr2:173955918chr2:174774985ENST0000031001557534_620676782.0RegionNote=Repressor domain
TgeneSP3chr2:173955918chr2:174774985ENST0000045578946138_237623729.0RegionNote=Transactivation domain (Gln-rich)
TgeneSP3chr2:173955918chr2:174774985ENST0000045578946350_499623729.0RegionNote=Transactivation domain (Gln-rich)
TgeneSP3chr2:173955918chr2:174774985ENST0000045578946534_620623729.0RegionNote=Repressor domain
TgeneSP3chr2:173955918chr2:174774985ENST0000031001557621_645676782.0Zinc fingerC2H2-type 1
TgeneSP3chr2:173955918chr2:174774985ENST0000031001557651_675676782.0Zinc fingerC2H2-type 2


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Fusion Gene Sequence for MLTK-SP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54348_54348_1_MLTK-SP3_MLTK_chr2_173955918_ENST00000338983_SP3_chr2_174774985_ENST00000418194_length(transcript)=2082nt_BP=354nt
CTTCCTCATTGGCGCCGTGCAGAGAGGCGGAATGTTCAACTCCTAACTGCAGCGGAAACGTGGGAGCCGCGCGGGCCGCTGTCGTCCCAA
CCCCCGCCGCCCTCGTCGCGCGCGGGGCCTCCGCGCCCCCGGCTGCTGCTCACGCCCCGCCCGGGAGCCAGATTTTGTGGAAGTATAATA
CTTTGTCATTATGAGATGTCGTCTCTCGGTGCCTCCTTTGTGCAAATTAAATTTGATGACTTGCAGTTTTTTGAAAACTGCGGTGGAGGA
AGTTTTGGGAGTGTTTATCGAGCCAAATGGATATCACAGGACAAGGAGGTGGCTGTAAAGAAGCTCCTCAAAATAGAGAAAGAGGTGAGA
AGAAATTTGTTTGTCCAGAATGTTCAAAACGCTTTATGAGAAGTGACCACCTTGCCAAACATATTAAAACACACCAGAATAAAAAAGGTA
TTCACTCTAGCAGTACAGTGCTGGCATCTGTGGAAGCTGCGCGAGATGATACTTTGATTACTGCAGGAGGAACAACGCTTATCCTTGCAA
ATATTCAACAAGGTTCTGTTTCAGGGATAGGAACTGTTAATACTTCCGCCACCAGCAATCAAGATATCCTTACCAACACTGAAATACCTT
TACAGCTTGTCACAGTTTCTGGAAATGAGACAATGGAGTAAATATTACACAAATACTTATTCATTGTGGTTATTTTTATACAGTAGTGAG
AAGAATATTGTTCCTAAGTTCTTAGATATCTTTTTATTGATGTGCAAAAATTTTTGGATTGACAGTAACTTGGTTATACATGACACTGAA
ATGCCTTACTTTGTATGATATTCCATAGTATATTAAAAATGGTAAAATTGCATGGGTTTTGTAGGTACTTTTGGAATCTAGAAGAAATGA
AATTTTACCAAGTTATATAAAGAGAAAATTGAATTTAACAATGCGAATGGTAGTCTAACCAAATGCATCAATCCTGTGTGGTTTAGTGTA
AAAATGAGAACATGTTGGTATTTATCTATTGTAAGATAAAAAAGCTGGTGGGTGAAAGAAATCATGTTATGATAAAAAATTTTGTAATTT
TCTTGATGACTGGAATTTTTATTATGCATAACTGACAAATCAAGTTTCCAAGCAAATGTTACATAGTGTAGGCTTTACTTAGCTTATCAA
TTTGTCATTTTGAAGCTAATTATTTTAATTAGGTTAACTATGTACAATATTTTAAGCATTACTCTTGTAAGATTTTGAAAACTACATTTT
AACATGGAACTCTAGGGATAGTCACCTTTTAAATCCTGTTGAAAAGCCATGTTTAAGATTTAATTTGCCAAAATAATGTCTTGTTAATAT
TCTTTCAATAACGAAGTTGGGCAATATAACCAATGTTTAAAAAAGTTTAAAATGTATAAGTTGAGGCATTTGGGTGGTAAGAGAATGTTA
TAGTGAATTATCCCTTTTCTTGACTATTGGAGGACCAAAAAAATAAGGTGTATTGCGTCTTAGCAGTGATTTTTATCCAATCTTGTTTCC
AAAAACCATGTCTCCCAGGGCCTTAAAAGCCATCATGTAAATTACCAGTAAAGTGTAACATATGCAAACATAACAAAATCACTTCCATAG
TGACGATACTCCAACCATATGGATATTAGTCATAGAAGAACTAGAGGTTTTATGATATTTTTTTAAGTCTTTTTTTTTTTTGTCTAGGTA
GTCAGTCTGCACTTAAATATCAATCATTTTCCTTTTTTGCTTCTTCCCTTAAAATTTATATGTATCCAGTACATTTAATTGAGAAGCGTA
TGTTTTTTATTATGCTGTATTTTCTTTTTATTTTTTAATTATTGTTTATATTTTCAATTCAAAAATGTACAAAATAAAGTTACATTGCTG
GTCTTGTAAGAGCTATACAGTTTTCCTAAATGTATACCTGTAACTGCAGCAGTTCACCTATTTCAAAAATTTGGAATTCTGTTCATTTGT
TATTCTTAAGACCACCTCAAATTTAAAGGCTACCTTATTGTACGTTTAAAGTGTATTATAACAGTGTGGTAGTTAATAAAACACTATTTT

>54348_54348_1_MLTK-SP3_MLTK_chr2_173955918_ENST00000338983_SP3_chr2_174774985_ENST00000418194_length(amino acids)=137AA_BP=32
MRWRKFWECLSSQMDITGQGGGCKEAPQNRERGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEAARDDTLITAGGTT

--------------------------------------------------------------
>54348_54348_2_MLTK-SP3_MLTK_chr2_173955918_ENST00000375213_SP3_chr2_174774985_ENST00000418194_length(transcript)=1965nt_BP=237nt
CCTCCGCGCCCCCGGCTGCTGCTCACGCCCCGCCCGGGAGCCAGATTTTGTGGAAGTATAATACTTTGTCATTATGAGATGTCGTCTCTC
GGTGCCTCCTTTGTGCAAATTAAATTTGATGACTTGCAGTTTTTTGAAAACTGCGGTGGAGGAAGTTTTGGGAGTGTTTATCGAGCCAAA
TGGATATCACAGGACAAGGAGGTGGCTGTAAAGAAGCTCCTCAAAATAGAGAAAGAGGTGAGAAGAAATTTGTTTGTCCAGAATGTTCAA
AACGCTTTATGAGAAGTGACCACCTTGCCAAACATATTAAAACACACCAGAATAAAAAAGGTATTCACTCTAGCAGTACAGTGCTGGCAT
CTGTGGAAGCTGCGCGAGATGATACTTTGATTACTGCAGGAGGAACAACGCTTATCCTTGCAAATATTCAACAAGGTTCTGTTTCAGGGA
TAGGAACTGTTAATACTTCCGCCACCAGCAATCAAGATATCCTTACCAACACTGAAATACCTTTACAGCTTGTCACAGTTTCTGGAAATG
AGACAATGGAGTAAATATTACACAAATACTTATTCATTGTGGTTATTTTTATACAGTAGTGAGAAGAATATTGTTCCTAAGTTCTTAGAT
ATCTTTTTATTGATGTGCAAAAATTTTTGGATTGACAGTAACTTGGTTATACATGACACTGAAATGCCTTACTTTGTATGATATTCCATA
GTATATTAAAAATGGTAAAATTGCATGGGTTTTGTAGGTACTTTTGGAATCTAGAAGAAATGAAATTTTACCAAGTTATATAAAGAGAAA
ATTGAATTTAACAATGCGAATGGTAGTCTAACCAAATGCATCAATCCTGTGTGGTTTAGTGTAAAAATGAGAACATGTTGGTATTTATCT
ATTGTAAGATAAAAAAGCTGGTGGGTGAAAGAAATCATGTTATGATAAAAAATTTTGTAATTTTCTTGATGACTGGAATTTTTATTATGC
ATAACTGACAAATCAAGTTTCCAAGCAAATGTTACATAGTGTAGGCTTTACTTAGCTTATCAATTTGTCATTTTGAAGCTAATTATTTTA
ATTAGGTTAACTATGTACAATATTTTAAGCATTACTCTTGTAAGATTTTGAAAACTACATTTTAACATGGAACTCTAGGGATAGTCACCT
TTTAAATCCTGTTGAAAAGCCATGTTTAAGATTTAATTTGCCAAAATAATGTCTTGTTAATATTCTTTCAATAACGAAGTTGGGCAATAT
AACCAATGTTTAAAAAAGTTTAAAATGTATAAGTTGAGGCATTTGGGTGGTAAGAGAATGTTATAGTGAATTATCCCTTTTCTTGACTAT
TGGAGGACCAAAAAAATAAGGTGTATTGCGTCTTAGCAGTGATTTTTATCCAATCTTGTTTCCAAAAACCATGTCTCCCAGGGCCTTAAA
AGCCATCATGTAAATTACCAGTAAAGTGTAACATATGCAAACATAACAAAATCACTTCCATAGTGACGATACTCCAACCATATGGATATT
AGTCATAGAAGAACTAGAGGTTTTATGATATTTTTTTAAGTCTTTTTTTTTTTTGTCTAGGTAGTCAGTCTGCACTTAAATATCAATCAT
TTTCCTTTTTTGCTTCTTCCCTTAAAATTTATATGTATCCAGTACATTTAATTGAGAAGCGTATGTTTTTTATTATGCTGTATTTTCTTT
TTATTTTTTAATTATTGTTTATATTTTCAATTCAAAAATGTACAAAATAAAGTTACATTGCTGGTCTTGTAAGAGCTATACAGTTTTCCT
AAATGTATACCTGTAACTGCAGCAGTTCACCTATTTCAAAAATTTGGAATTCTGTTCATTTGTTATTCTTAAGACCACCTCAAATTTAAA

>54348_54348_2_MLTK-SP3_MLTK_chr2_173955918_ENST00000375213_SP3_chr2_174774985_ENST00000418194_length(amino acids)=137AA_BP=32
MRWRKFWECLSSQMDITGQGGGCKEAPQNRERGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEAARDDTLITAGGTT

--------------------------------------------------------------
>54348_54348_3_MLTK-SP3_MLTK_chr2_173955918_ENST00000409176_SP3_chr2_174774985_ENST00000418194_length(transcript)=2023nt_BP=295nt
GGTGCCCCCCGGGCGCAGGCCAGGGAGGCCCGAGCGCCTTCCCCACGCCCCGCTCGCCCGCGCGTGTGAGGGGAGGGCGGCCCAGCCGTT
TCGCGCCGGGAGATTTTGTGGAAGTATAATACTTTGTCATTATGAGATGTCGTCTCTCGGTGCCTCCTTTGTGCAAATTAAATTTGATGA
CTTGCAGTTTTTTGAAAACTGCGGTGGAGGAAGTTTTGGGAGTGTTTATCGAGCCAAATGGATATCACAGGACAAGGAGGTGGCTGTAAA
GAAGCTCCTCAAAATAGAGAAAGAGGTGAGAAGAAATTTGTTTGTCCAGAATGTTCAAAACGCTTTATGAGAAGTGACCACCTTGCCAAA
CATATTAAAACACACCAGAATAAAAAAGGTATTCACTCTAGCAGTACAGTGCTGGCATCTGTGGAAGCTGCGCGAGATGATACTTTGATT
ACTGCAGGAGGAACAACGCTTATCCTTGCAAATATTCAACAAGGTTCTGTTTCAGGGATAGGAACTGTTAATACTTCCGCCACCAGCAAT
CAAGATATCCTTACCAACACTGAAATACCTTTACAGCTTGTCACAGTTTCTGGAAATGAGACAATGGAGTAAATATTACACAAATACTTA
TTCATTGTGGTTATTTTTATACAGTAGTGAGAAGAATATTGTTCCTAAGTTCTTAGATATCTTTTTATTGATGTGCAAAAATTTTTGGAT
TGACAGTAACTTGGTTATACATGACACTGAAATGCCTTACTTTGTATGATATTCCATAGTATATTAAAAATGGTAAAATTGCATGGGTTT
TGTAGGTACTTTTGGAATCTAGAAGAAATGAAATTTTACCAAGTTATATAAAGAGAAAATTGAATTTAACAATGCGAATGGTAGTCTAAC
CAAATGCATCAATCCTGTGTGGTTTAGTGTAAAAATGAGAACATGTTGGTATTTATCTATTGTAAGATAAAAAAGCTGGTGGGTGAAAGA
AATCATGTTATGATAAAAAATTTTGTAATTTTCTTGATGACTGGAATTTTTATTATGCATAACTGACAAATCAAGTTTCCAAGCAAATGT
TACATAGTGTAGGCTTTACTTAGCTTATCAATTTGTCATTTTGAAGCTAATTATTTTAATTAGGTTAACTATGTACAATATTTTAAGCAT
TACTCTTGTAAGATTTTGAAAACTACATTTTAACATGGAACTCTAGGGATAGTCACCTTTTAAATCCTGTTGAAAAGCCATGTTTAAGAT
TTAATTTGCCAAAATAATGTCTTGTTAATATTCTTTCAATAACGAAGTTGGGCAATATAACCAATGTTTAAAAAAGTTTAAAATGTATAA
GTTGAGGCATTTGGGTGGTAAGAGAATGTTATAGTGAATTATCCCTTTTCTTGACTATTGGAGGACCAAAAAAATAAGGTGTATTGCGTC
TTAGCAGTGATTTTTATCCAATCTTGTTTCCAAAAACCATGTCTCCCAGGGCCTTAAAAGCCATCATGTAAATTACCAGTAAAGTGTAAC
ATATGCAAACATAACAAAATCACTTCCATAGTGACGATACTCCAACCATATGGATATTAGTCATAGAAGAACTAGAGGTTTTATGATATT
TTTTTAAGTCTTTTTTTTTTTTGTCTAGGTAGTCAGTCTGCACTTAAATATCAATCATTTTCCTTTTTTGCTTCTTCCCTTAAAATTTAT
ATGTATCCAGTACATTTAATTGAGAAGCGTATGTTTTTTATTATGCTGTATTTTCTTTTTATTTTTTAATTATTGTTTATATTTTCAATT
CAAAAATGTACAAAATAAAGTTACATTGCTGGTCTTGTAAGAGCTATACAGTTTTCCTAAATGTATACCTGTAACTGCAGCAGTTCACCT
ATTTCAAAAATTTGGAATTCTGTTCATTTGTTATTCTTAAGACCACCTCAAATTTAAAGGCTACCTTATTGTACGTTTAAAGTGTATTAT

>54348_54348_3_MLTK-SP3_MLTK_chr2_173955918_ENST00000409176_SP3_chr2_174774985_ENST00000418194_length(amino acids)=137AA_BP=32
MRWRKFWECLSSQMDITGQGGGCKEAPQNRERGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEAARDDTLITAGGTT

--------------------------------------------------------------
>54348_54348_4_MLTK-SP3_MLTK_chr2_173955918_ENST00000539448_SP3_chr2_174774985_ENST00000418194_length(transcript)=2157nt_BP=429nt
AGAGAGGCAGCCTTCAGACCTATGTTCCCAGAAATCTCTACGTTTGTGCCTTTCCCAACTAGAGAATTAACTCTTGCGGGGCACAAAACA
GCCTCTATTTCTTTGCGTCCCCAGCGCCTGTTTGTTGAAGACTGAGTTGAAGGAGTAGCAGGTGGTGTTAATTTGTCAAAAAGATGAGTT
AAGGTGCTGGGGGCGAGGGGGAACACCCCCACGGCCCTCCCCCCACAGCAAGGCAGATTTTGTGGAAGTATAATACTTTGTCATTATGAG
ATGTCGTCTCTCGGTGCCTCCTTTGTGCAAATTAAATTTGATGACTTGCAGTTTTTTGAAAACTGCGGTGGAGGAAGTTTTGGGAGTGTT
TATCGAGCCAAATGGATATCACAGGACAAGGAGGTGGCTGTAAAGAAGCTCCTCAAAATAGAGAAAGAGGTGAGAAGAAATTTGTTTGTC
CAGAATGTTCAAAACGCTTTATGAGAAGTGACCACCTTGCCAAACATATTAAAACACACCAGAATAAAAAAGGTATTCACTCTAGCAGTA
CAGTGCTGGCATCTGTGGAAGCTGCGCGAGATGATACTTTGATTACTGCAGGAGGAACAACGCTTATCCTTGCAAATATTCAACAAGGTT
CTGTTTCAGGGATAGGAACTGTTAATACTTCCGCCACCAGCAATCAAGATATCCTTACCAACACTGAAATACCTTTACAGCTTGTCACAG
TTTCTGGAAATGAGACAATGGAGTAAATATTACACAAATACTTATTCATTGTGGTTATTTTTATACAGTAGTGAGAAGAATATTGTTCCT
AAGTTCTTAGATATCTTTTTATTGATGTGCAAAAATTTTTGGATTGACAGTAACTTGGTTATACATGACACTGAAATGCCTTACTTTGTA
TGATATTCCATAGTATATTAAAAATGGTAAAATTGCATGGGTTTTGTAGGTACTTTTGGAATCTAGAAGAAATGAAATTTTACCAAGTTA
TATAAAGAGAAAATTGAATTTAACAATGCGAATGGTAGTCTAACCAAATGCATCAATCCTGTGTGGTTTAGTGTAAAAATGAGAACATGT
TGGTATTTATCTATTGTAAGATAAAAAAGCTGGTGGGTGAAAGAAATCATGTTATGATAAAAAATTTTGTAATTTTCTTGATGACTGGAA
TTTTTATTATGCATAACTGACAAATCAAGTTTCCAAGCAAATGTTACATAGTGTAGGCTTTACTTAGCTTATCAATTTGTCATTTTGAAG
CTAATTATTTTAATTAGGTTAACTATGTACAATATTTTAAGCATTACTCTTGTAAGATTTTGAAAACTACATTTTAACATGGAACTCTAG
GGATAGTCACCTTTTAAATCCTGTTGAAAAGCCATGTTTAAGATTTAATTTGCCAAAATAATGTCTTGTTAATATTCTTTCAATAACGAA
GTTGGGCAATATAACCAATGTTTAAAAAAGTTTAAAATGTATAAGTTGAGGCATTTGGGTGGTAAGAGAATGTTATAGTGAATTATCCCT
TTTCTTGACTATTGGAGGACCAAAAAAATAAGGTGTATTGCGTCTTAGCAGTGATTTTTATCCAATCTTGTTTCCAAAAACCATGTCTCC
CAGGGCCTTAAAAGCCATCATGTAAATTACCAGTAAAGTGTAACATATGCAAACATAACAAAATCACTTCCATAGTGACGATACTCCAAC
CATATGGATATTAGTCATAGAAGAACTAGAGGTTTTATGATATTTTTTTAAGTCTTTTTTTTTTTTGTCTAGGTAGTCAGTCTGCACTTA
AATATCAATCATTTTCCTTTTTTGCTTCTTCCCTTAAAATTTATATGTATCCAGTACATTTAATTGAGAAGCGTATGTTTTTTATTATGC
TGTATTTTCTTTTTATTTTTTAATTATTGTTTATATTTTCAATTCAAAAATGTACAAAATAAAGTTACATTGCTGGTCTTGTAAGAGCTA
TACAGTTTTCCTAAATGTATACCTGTAACTGCAGCAGTTCACCTATTTCAAAAATTTGGAATTCTGTTCATTTGTTATTCTTAAGACCAC

>54348_54348_4_MLTK-SP3_MLTK_chr2_173955918_ENST00000539448_SP3_chr2_174774985_ENST00000418194_length(amino acids)=137AA_BP=32
MRWRKFWECLSSQMDITGQGGGCKEAPQNRERGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEAARDDTLITAGGTT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MLTK-SP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MLTK-SP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MLTK-SP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource