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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MLYCD-MGRN1 (FusionGDB2 ID:54363) |
Fusion Gene Summary for MLYCD-MGRN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MLYCD-MGRN1 | Fusion gene ID: 54363 | Hgene | Tgene | Gene symbol | MLYCD | MGRN1 | Gene ID | 23417 | 23295 |
| Gene name | malonyl-CoA decarboxylase | mahogunin ring finger 1 | |
| Synonyms | MCD | RNF156 | |
| Cytomap | 16q23.3 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | malonyl-CoA decarboxylase, mitochondrialmalonyl coenzyme A decarboxylase | E3 ubiquitin-protein ligase MGRN1RING finger protein 156RING-type E3 ubiquitin transferase MGRN1mahogunin RING finger protein 1mahogunin ring finger 1, E3 ubiquitin protein ligaseprobable E3 ubiquitin-protein ligase MGRN1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | O60291 | |
| Ensembl transtripts involved in fusion gene | ENST00000262430, | ENST00000588015, ENST00000262370, ENST00000399577, ENST00000415496, ENST00000586183, ENST00000588994, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 8 X 12 X 6=576 |
| # samples | 3 | 11 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/576*10)=-2.38856528791765 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MLYCD [Title/Abstract] AND MGRN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MLYCD(83945972)-MGRN1(4718266), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MLYCD | GO:0006085 | acetyl-CoA biosynthetic process | 9869665|10417274|10455107 |
| Hgene | MLYCD | GO:0006633 | fatty acid biosynthetic process | 15003260 |
| Hgene | MLYCD | GO:2001294 | malonyl-CoA catabolic process | 10417274|10455107|15003260 |
| Tgene | MGRN1 | GO:0043951 | negative regulation of cAMP-mediated signaling | 19737927 |
| Tgene | MGRN1 | GO:0045744 | negative regulation of G protein-coupled receptor signaling pathway | 19737927 |
| Fusion gene breakpoints across MLYCD (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MGRN1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-EJ-5524-01A | MLYCD | chr16 | 83945972 | - | MGRN1 | chr16 | 4718266 | + |
| ChimerDB4 | PRAD | TCGA-EJ-5524-01A | MLYCD | chr16 | 83945972 | + | MGRN1 | chr16 | 4718266 | + |
| ChimerDB4 | PRAD | TCGA-EJ-5524 | MLYCD | chr16 | 83945972 | + | MGRN1 | chr16 | 4718266 | + |
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Fusion Gene ORF analysis for MLYCD-MGRN1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000262430 | ENST00000588015 | MLYCD | chr16 | 83945972 | + | MGRN1 | chr16 | 4718266 | + |
| In-frame | ENST00000262430 | ENST00000262370 | MLYCD | chr16 | 83945972 | + | MGRN1 | chr16 | 4718266 | + |
| In-frame | ENST00000262430 | ENST00000399577 | MLYCD | chr16 | 83945972 | + | MGRN1 | chr16 | 4718266 | + |
| In-frame | ENST00000262430 | ENST00000415496 | MLYCD | chr16 | 83945972 | + | MGRN1 | chr16 | 4718266 | + |
| In-frame | ENST00000262430 | ENST00000586183 | MLYCD | chr16 | 83945972 | + | MGRN1 | chr16 | 4718266 | + |
| In-frame | ENST00000262430 | ENST00000588994 | MLYCD | chr16 | 83945972 | + | MGRN1 | chr16 | 4718266 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000262430 | MLYCD | chr16 | 83945972 | + | ENST00000262370 | MGRN1 | chr16 | 4718266 | + | 4084 | 967 | 4 | 2019 | 671 |
| ENST00000262430 | MLYCD | chr16 | 83945972 | + | ENST00000415496 | MGRN1 | chr16 | 4718266 | + | 6557 | 967 | 4 | 1881 | 625 |
| ENST00000262430 | MLYCD | chr16 | 83945972 | + | ENST00000399577 | MGRN1 | chr16 | 4718266 | + | 6621 | 967 | 4 | 1947 | 647 |
| ENST00000262430 | MLYCD | chr16 | 83945972 | + | ENST00000588994 | MGRN1 | chr16 | 4718266 | + | 1954 | 967 | 4 | 1953 | 650 |
| ENST00000262430 | MLYCD | chr16 | 83945972 | + | ENST00000586183 | MGRN1 | chr16 | 4718266 | + | 2130 | 967 | 4 | 1881 | 625 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000262430 | ENST00000262370 | MLYCD | chr16 | 83945972 | + | MGRN1 | chr16 | 4718266 | + | 0.035671473 | 0.9643285 |
| ENST00000262430 | ENST00000415496 | MLYCD | chr16 | 83945972 | + | MGRN1 | chr16 | 4718266 | + | 0.010301906 | 0.9896981 |
| ENST00000262430 | ENST00000399577 | MLYCD | chr16 | 83945972 | + | MGRN1 | chr16 | 4718266 | + | 0.010355004 | 0.989645 |
| ENST00000262430 | ENST00000588994 | MLYCD | chr16 | 83945972 | + | MGRN1 | chr16 | 4718266 | + | 0.05546463 | 0.9445353 |
| ENST00000262430 | ENST00000586183 | MLYCD | chr16 | 83945972 | + | MGRN1 | chr16 | 4718266 | + | 0.038473904 | 0.96152616 |
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Fusion Genomic Features for MLYCD-MGRN1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MLYCD-MGRN1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:83945972/chr16:4718266) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | MGRN1 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MLYCD | chr16:83945972 | chr16:4718266 | ENST00000262430 | + | 4 | 5 | 299_305 | 316 | 494.0 | Region | Malonyl-CoA binding |
| Hgene | MLYCD | chr16:83945972 | chr16:4718266 | ENST00000262430 | + | 4 | 5 | 40_190 | 316 | 494.0 | Region | Note=Alpha-helical domain |
| Tgene | MGRN1 | chr16:83945972 | chr16:4718266 | ENST00000262370 | 6 | 17 | 278_317 | 226 | 577.0 | Zinc finger | RING-type | |
| Tgene | MGRN1 | chr16:83945972 | chr16:4718266 | ENST00000399577 | 6 | 17 | 278_317 | 226 | 553.0 | Zinc finger | RING-type | |
| Tgene | MGRN1 | chr16:83945972 | chr16:4718266 | ENST00000586183 | 6 | 17 | 278_317 | 226 | 583.0 | Zinc finger | RING-type | |
| Tgene | MGRN1 | chr16:83945972 | chr16:4718266 | ENST00000588994 | 6 | 16 | 278_317 | 226 | 555.0 | Zinc finger | RING-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MLYCD | chr16:83945972 | chr16:4718266 | ENST00000262430 | + | 4 | 5 | 491_493 | 316 | 494.0 | Motif | Microbody targeting signal |
| Hgene | MLYCD | chr16:83945972 | chr16:4718266 | ENST00000262430 | + | 4 | 5 | 191_493 | 316 | 494.0 | Region | Note=Catalytic domain |
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Fusion Gene Sequence for MLYCD-MGRN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >54363_54363_1_MLYCD-MGRN1_MLYCD_chr16_83945972_ENST00000262430_MGRN1_chr16_4718266_ENST00000262370_length(transcript)=4084nt_BP=967nt GCAGCTGTTGTGGGGCACCATGCGAGGCTTCGGGCCAGGCTTGACGGCCAGGCGTCTCCTCCCGCTGCGGTTGCCCCCGCGGCCGCCCGG GCCCCGGCTGGCGAGCGGGCAGGCGGCCGGCGCCCTGGAGCGGGCCATGGACGAGCTGCTGCGCCGCGCGGTGCCGCCGACGCCGGCCTA CGAGCTGCGCGAGAAGACACCGGCGCCCGCCGAGGGTCAGTGCGCGGACTTCGTGAGCTTCTACGGTGGGCTGGCCGAGACGGCCCAGCG GGCCGAACTGCTGGGCCGCCTGGCGCGGGGCTTCGGCGTGGACCACGGCCAGGTGGCGGAGCAGAGCGCCGGCGTGCTCCATCTGCGCCA GCAGCAGCGGGAGGCGGCGGTGCTGCTGCAGGCCGAGGACCGGCTGCGCTACGCGCTGGTGCCGCGCTATCGCGGCCTCTTCCACCACAT CAGCAAGCTGGACGGCGGCGTGCGCTTCCTGGTGCAGCTGCGGGCCGACCTGCTGGAGGCGCAGGCCCTCAAGCTGGTGGAGGGGCCGGA CGTCCGGGAAATGAATGGGGTGCTGAAAGGAATGCTCTCAGAATGGTTTTCCTCCGGGTTCCTGAACCTAGAACGGGTTACCTGGCATTC ACCGTGTGAAGTGCTTCAGAAAATCAGTGAGGCTGAGGCTGTGCATCCTGTAAAAAACTGGATGGACATGAAGCGCCGCGTTGGGCCCTA CAGAAGGTGTTACTTCTTTTCTCACTGTTCGACCCCTGGGGAGCCCCTGGTCGTTTTGCACGTGGCACTGACTGGTGACATCTCCAGCAA CATCCAGGCAATCGTGAAGGAACATCCTCCATCAGAAACAGAAGAGAAGAACAAAATCACTGCTGCGATCTTTTATTCCATCAGCTTGAC CCAGCAGGGACTCCAAGGGGTGGAGCTGGGAACATTCCTCATAAAGCGAGTCGTCAAGGAGTTGCAGCACATGGACGGCAGCTTCTCTGT GAAGCCTTTAAAGCAGAAGCAAATTGTGGACCGGGTCAGCTACCTCCTGCAGGAGATCTATGGCATTGAGAACAAGAACAACCAGGAGAC CAAGCCCTCGGACGACGAGAACAGCGACAACAGCAACGAGTGTGTGGTGTGCCTGTCCGACCTGCGGGACACGCTGATCCTGCCCTGCCG CCACCTGTGCCTCTGTACCTCCTGCGCCGACACGCTGCGCTACCAGGCCAACAACTGCCCCATCTGCCGGCTGCCTTTCCGGGCCCTCCT GCAGATCCGGGCGGTGCGGAAGAAGCCAGGAGCCCTGTCCCCCGTGTCCTTCAGCCCCGTCCTGGCCCAGAGCCTGGAGCATGATGAGCA CTCTTGTCCCTTTAAAAAATCAAAGCCGCACCCCGCCTCCCTGGCCAGCAAGAAACCTAAAAGGGAAACAAACTCTGACAGCGTCCCACC TGGCTACGAGCCCATCTCGCTGCTCGAGGCGCTCAACGGCCTCCGGGCTGTCTCCCCGGCCATCCCCTCGGCCCCTCTTTATGAAGAAAT CACCTATTCAGGCATCTCGGACGGCCTGTCCCAGGCCAGCTGTCCCCTCGCGGCTATCGACCACATCCTGGACAGCAGCCGCCAGAAGGG CAGGCCGCAGAGCAAGGCCCCCGACAGCACCCTACGGTCCCCGTCTTCCCCCATCCACGAAGAGGATGAGGAGAAGCTCTCCGAGGACGT GGACGCCCCTCCCCCACTGGGTGGCGCAGAGCTGGCCCTGCGGGAAAGCAGCTCCCCTGAGAGTTTCATAACAGAAGAGGTTGATGAGTC GTCGTCACCACAGCAAGGGACCCGAGCAGCTTCCATTGAGAATGTCCTGCAGGACAGCAGCCCCGAGCACTGTGGCCGAGGCCCACCTGC TGACATCTACCTGCCAGGACGGCCCACCTCCATGGAGACGGCCCACGGCCTCGCCACCACCAGCCCCACCTGGCCTCCACTTGGTGGCCC CAGCCCCGATCCCAGCGCCGCCGAGCTGACCCCACTCTGAGAGCCTGGCCGAGCTGGCAGCATGGAGCCCTCGGCTCCCCAGACTTTGCC GAGGGGCTGCTCCGGACCCCGTTGTGAGCCGGCCTCCTGTCTGCATGCCCCCTGTGGCCACCAGGCTCCGAGGGGCCGTGGTGACTCTTG ATCAAAGAGCACAGTGAACTGTCCCTTCTGAGTCTCCCTTTTCTACAGTTGATATATTTGTAACTGGTACAAGATGAAGGACAGCAGCTT TCCATCCCTAGTTCAGAGCCCCCGTTCCCCAGGGTCCTGTGGGCTGAGCGGCTGGGGCTGGGGCTGCCCACGTGTGGCCTCCGCTGGCTC TGCCTGCTCCTGCAACAGTGCGGTCCCTGCCCGGAGAACTCAGGAGGCCTGCAGAAGAGAACTGATTGGTGGTCGAAGCACCATCTTCAC AGATGTTCAGGGGCAGTGGGGGGCTCCAGGCACGGTCAATGAAGGAAACAGTGCCTGTCCACCCACCCTGCGTGTCACTGTGGCGGCCTG GCTGTCGCTGCTTTTTGTCCTCTGCCGTGTTTGCGCGGCCTCAGTGCCCTCCCTGGTGCGTCTGCGCTGGGGCCCTCAGTGCTCGGGGCC TTGGGGTGCATGGGTGCCGCCCTGGGCAGCTAGAGTGTCTCAGCCCGGTGCTGGGCCTGGCCGAGGGGCGGAGGCACAGCTGCTTCCAGC AGCCAGCATTCAGTGGCCTTGTCACCAAGCTCCACACCTCCTCCTGGTGCTGGCTTTGGTGACATCACAAGGCCCCTCCAGGTGCAGGGG CTTCTGTTTGGCAGGCCCCTGCCAGGGAGGACCTGGTGGCCTCCTCATTCTCTTTTGCCATTGGAATGTCCCCTTGCAGTTCTCTTCTCT TTTTTTTTTTTTTTGAGATGGAGTTTCACTCTTGCTGCCCAGGCTGGAGTGCAGTGGCTCAATCTCGGGTCACTGCAACCTCCGCCTCCC GGGTTCAAGTGATCGTCCTGCCTTAGGCTCCTGAGTAGCTGGGGATTACAGGTGCCTACCAGCATGCTCGGCTAATTTTTTTGTATTTTT AGTAGAGAAGGGATTTCACCATGTTGGCCGGGCTGGTCTCAAACTCCTAAGGTCATCCACCTGCCTCGGCCTCCCAGAGTGCTGAGATTA CAGGCGTGAGCCTCCGCGCCCGGCCCCCTTGCAGTTCTCTCTGATTTGGTTTGTTCTGTCTCAGGCTTCTGTGGCAGGACTGGCCCAGGG AGGAGGAAGCCAGCAGCACACCTGGGGAATGGGGTCCCGGCCGGGAGGCTTGGCCTCTGGGCGACCTCGTCCTGTTTTTTTTGTTTGTTT GTTTGTTTTTTTAAAGGTAAACCTCCTGGGCCGCAGATGGCAAAGGGAGTGCCTGGGCCTGGTGACCCAGGGCTGGATCCACCCCTGCGG AGCCCTGGGCCAGGCAGGTGTCTGCTGCTCACCTGGCTCTGGAGGGCTGCCCTGCAGCTGGGCCTGGGGACAGGTCGGCTGTGGGGCAGC TCAGTACCCTCCCTGAGGCTCACGGTGGCTCCGAGCATGAGGTCCGCCTCCTGGGCGAGACCCAGCAGTGGACAGCATGGTCCTCACACC CAGCTCCCTGCACACCCAGGCCAGCCACCCCTCCCGCTCGTGCACAGGCACGCAGATGCGCTCACACGTACACACACACAAATGCACGCC CACTTGCACATGCTCACGCACATGTTCACACATGCACACTCACGCTCACACATGCTGTCACGCATACACACACGCACATACTCCTGCACA TGTTCCCATGCATGTGTGTGCACTCGGACCGAGCATCTCCCACGCACCTCTACCCCACCCCAAGCACCTCTCTCCCCCCATGCACCTCTC CCCAACAACACACACAGCCCCCTGCACCGCCCGCCCCCCGCCCCCACCAAGGCCCCAGCCTCTGGCCATCAGTCCTGGTGCCAGAGCTTT GCGTGAAGTTCGGGCCGCAGAGTGGCCCGCTGGGACTCCCATGTGCTGCCGTCTGATGTGCTCAGATGGGCTCATCGTTGGTTCGTTTTT >54363_54363_1_MLYCD-MGRN1_MLYCD_chr16_83945972_ENST00000262430_MGRN1_chr16_4718266_ENST00000262370_length(amino acids)=671AA_BP=319 MLWGTMRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRA ELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDV REMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNI QAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETK PSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHS CPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAAIDHILDSSRQKGR PQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPAD -------------------------------------------------------------- >54363_54363_2_MLYCD-MGRN1_MLYCD_chr16_83945972_ENST00000262430_MGRN1_chr16_4718266_ENST00000399577_length(transcript)=6621nt_BP=967nt GCAGCTGTTGTGGGGCACCATGCGAGGCTTCGGGCCAGGCTTGACGGCCAGGCGTCTCCTCCCGCTGCGGTTGCCCCCGCGGCCGCCCGG GCCCCGGCTGGCGAGCGGGCAGGCGGCCGGCGCCCTGGAGCGGGCCATGGACGAGCTGCTGCGCCGCGCGGTGCCGCCGACGCCGGCCTA CGAGCTGCGCGAGAAGACACCGGCGCCCGCCGAGGGTCAGTGCGCGGACTTCGTGAGCTTCTACGGTGGGCTGGCCGAGACGGCCCAGCG GGCCGAACTGCTGGGCCGCCTGGCGCGGGGCTTCGGCGTGGACCACGGCCAGGTGGCGGAGCAGAGCGCCGGCGTGCTCCATCTGCGCCA GCAGCAGCGGGAGGCGGCGGTGCTGCTGCAGGCCGAGGACCGGCTGCGCTACGCGCTGGTGCCGCGCTATCGCGGCCTCTTCCACCACAT CAGCAAGCTGGACGGCGGCGTGCGCTTCCTGGTGCAGCTGCGGGCCGACCTGCTGGAGGCGCAGGCCCTCAAGCTGGTGGAGGGGCCGGA CGTCCGGGAAATGAATGGGGTGCTGAAAGGAATGCTCTCAGAATGGTTTTCCTCCGGGTTCCTGAACCTAGAACGGGTTACCTGGCATTC ACCGTGTGAAGTGCTTCAGAAAATCAGTGAGGCTGAGGCTGTGCATCCTGTAAAAAACTGGATGGACATGAAGCGCCGCGTTGGGCCCTA CAGAAGGTGTTACTTCTTTTCTCACTGTTCGACCCCTGGGGAGCCCCTGGTCGTTTTGCACGTGGCACTGACTGGTGACATCTCCAGCAA CATCCAGGCAATCGTGAAGGAACATCCTCCATCAGAAACAGAAGAGAAGAACAAAATCACTGCTGCGATCTTTTATTCCATCAGCTTGAC CCAGCAGGGACTCCAAGGGGTGGAGCTGGGAACATTCCTCATAAAGCGAGTCGTCAAGGAGTTGCAGCACATGGACGGCAGCTTCTCTGT GAAGCCTTTAAAGCAGAAGCAAATTGTGGACCGGGTCAGCTACCTCCTGCAGGAGATCTATGGCATTGAGAACAAGAACAACCAGGAGAC CAAGCCCTCGGACGACGAGAACAGCGACAACAGCAACGAGTGTGTGGTGTGCCTGTCCGACCTGCGGGACACGCTGATCCTGCCCTGCCG CCACCTGTGCCTCTGTACCTCCTGCGCCGACACGCTGCGCTACCAGGCCAACAACTGCCCCATCTGCCGGCTGCCTTTCCGGGCCCTCCT GCAGATCCGGGCGGTGCGGAAGAAGCCAGGAGCCCTGTCCCCCGTGTCCTTCAGCCCCGTCCTGGCCCAGAGCCTGGAGCATGATGAGCA CTCTTGTCCCTTTAAAAAATCAAAGCCGCACCCCGCCTCCCTGGCCAGCAAGAAACCTAAAAGGGAAACAAACTCTGACAGCGTCCCACC TGGCTACGAGCCCATCTCGCTGCTCGAGGCGCTCAACGGCCTCCGGGCTGTCTCCCCGGCCATCCCCTCGGCCCCTCTTTATGAAGAAAT CACCTATTCAGGCATCTCGGACGGCCTGTCCCAGGCCAGCTGTCCCCTCGCGGCTATCGACCACATCCTGGACAGCAGCCGCCAGAAGGG CAGGCCGCAGAGCAAGGCCCCCGACAGCACCCTACGGTCCCCGTCTTCCCCCATCCACGAAGAGGATGAGGAGAAGCTCTCCGAGGACGT GGACGCCCCTCCCCCACTGGGTGGCGCAGAGCTGGCCCTGCGGGAAAGCAGCTCCCCTGAGAGTTTCATAACAGAAGAGGTTGATGAGTC GTCGTCACCACAGCAAGGGACCCGAGCAGCTTCCATTGAGAATGTCCTGCAGGACAGCAGCCCCGAGCACTGTGGCCGAGGCCCACCTGC TGACATCTACCTGCCAGCCCTGGGGCCCGACTCCTGCTCTGTTGGTATAGACGAGTAAGCCGGTACGTGACCTCCCAGACGCGCTTCGGG GGCTCTGACGCGCGTCCTTGGAGAGAGGAGCCCTCCCCTGCTCTCTGGCGGGGGTTCCTTCTGGTTTTTGGGTCTTCGTCCGCATCCGCA TCTTCCCAGGGGCCCTGGATTCCGAATCCAGAGCTCTCCAGTGGCTGCTGCACCTTCCCCCAGAAAGTGGCCTCCTGGGGGGTCCTGACT TTCGGGGCCAGAGGTCTCTCCATCTGGACTAGGCGGCCGGTCAGGCTCTTCTTCCAGCCTTGAGGGGCCCTGGAACAGTCCCAGCCCAGG CAGGGAGACAGACACAGCCCAGGTGCGCCAGAGCCACTGTCCACTGCGGGAGGCAGGAGCTTGAGGGATGAGGGCAGCACCGTGGAGGGA ACCCCAGGGAGACATGGGGTGAGCGTCCCAAGGGGAGAGGCCTGGGCCTGGCCTTGTTCCGGATGGTCCCACCATGAGTTCGCATCGGTC CTGCAGCAGACACGTTAGGACGCTCAGCAGGTCCACTCCCGTGTTCCGGTCGTGGCTTTAACAATTCATGGGGAAAGAATGCGCCCCGAT TGGGAGAGCCCCTGGATCACGTCTTCCCAAGCTCAGTCCCTGTCTCTTGGAGGGAGTCCGTCCTCGAGGGGCCCTCTGGTGCCCAGGGGA GAGTATCTTGCGTCCTGTCCTGAGGGCGTCCGCTCACACAGCCACCTGCTCCCCCGCTCCCTCCTTCCCTTGTCAGCATGGCCACCGTGG GCCTGGCATCACCATGGGCCTGGCACACAGTCCCTCGTGGGCTGCCTTTGTGCCATGAGCCCACTGCTGCCGACTCACCTGTCCCTCCCA GTACTGGAACCTTCTGGAACACCAGCACTAAAAGATAGGAGGCCCTGTGAGGTTGGCATCCCCCATCCCCCCCAAGAGGCGCCCTCTACC AGGGTGGCCCAGGTGAGTGTTTTACAGAAGGCGGCTCTGTCCAGGCAGTGGTTCGCACCTATAAGCCCGGTACTTTGGGAGACCGAGGGG ATAGATCACTTGAGCCCAGGAATTCAAGATCAGTGTAGAAAACATAGACCCCCTCTCTATGAAAAATAAAAAATTGGCTTGGGCGTGGTA GCTTGTGCCTGTGGTCCCAGCTACTCAGGGGTGCTGAGGTGGGAGGATTGCCGGAGCTGGGGAGGTCAAGGCCCACTCCAGCCTGAGACG CTGTCTCAATAAAAAAAAATACACACACACCCACCCACCCACTCCAGCCTGAGACCCTGTCTCAAGAAAAAAAAAATACACACACACACA CACACACACACACACACGGGGGAGAGAGAGAAGGCAGCTCCAGGAGTGCCACCAAAATGTAGGCAGACGGATTGGGGACCCTCTGCCTTC CCAGAGGGTCTTGGCACACAAGCTGCGTGCAGCTCTGGTCTGCCGAGGCCCATGCAGCCTGCTGGGAGGTGCCTGGCCGGGGGTGCAGGC TCTAAGAGGCCCTTTCCCCTTGGGTGGACTTGAGCCGGGTCAGGGAGAACTTCGCTTCTTTTGACTGCGCTCTGCATTCCCATGAACCTC TGTCTTCTTGAGCCCAGCGAGTCCCTCTGTTGACCCCTGTCCTGAGCCATTATACCCCTAGATTGAAACAGTCAGCACCTTTCAGACGGC CCCGGCCTGCGCATCGGTGGAAGGTGCCGTGCGAATGTCACGATTCAGGTCAAGCTTCCGGAGCTGGGGAGTGCAGGTGTGATCTAGAAC AGGGCTCACAGCCTCGGAAACCTGCTCTCGCCGCGGCCCCCGAAGAAAATAGACGCCCTTCACCGGAGAGTGGGGCCTGGGCCGTGTCTG CTGGGAGCCATGTGTCAGGGCTGGTGGCTGGGTGTCAGGCAGCCCTGAGGCCATGCTGGCCCCGTCCCAGGCTCTGCACCAGCACCATTG CCCAAGCCCCAGGGACGCCAGACCCATCTGGGGACAGCGCCCGGCGGCGTCGTGCAGGCCACAGTCTGGGCATTGGGGCTCTGTGGGAGG CTCCTCTCTTTGCCTTGCAGTAGCCATCCGGGGGCTACTCTGAGCACGGGCTTGTTCTCACCCAGGGCCGCTCCCCACCCCTGCACCCTG GGTTGACCGAGTTCCACCCTAACCCAGCCGTAAGAACCTTGGCAGGACAGTGGCTGGCCACATCCCAGGAAACCGGAACCAGGGCAAGGG CAGGAGGCCCAGAGGGCATCCACCGCGGTGCCGTGTCGCGCTCTGACTCGGGGCTGCAGATCTGCTGTGGGTGTCCGGGGATCTGGGATC GTCTGTCCCAAGAGGGACACAGCGTATTTGGCACAGTTAGGGAGTCCCCGGGCCCTTGGTGTGCTCACATCTGAGTGAATGCTGTTGTGG CCACAGGCGGCGGGAGTGGGGGTGCTGGATGGCCCAGCCCCTCTGGGGCTCCAGATCGGTAGGAGCGGGTGGCGTGGCACCAGGCATCCG AGTGTGACCCTCCTCCCTCTGCTCCCACCTGCAGGACGGCCCACCTCCATGGAGACGGCCCACGGCCTCGCCACCACCAGCCCCACCTGG CCTCCACTTGGTGGCCCCAGCCCCGATCCCAGCGCCGCCGAGCTGACCCCACTCTGAGAGCCTGGCCGAGCTGGCAGCATGGAGCCCTCG GCTCCCCAGACTTTGCCGAGGGGCTGCTCCGGACCCCGTTGTGAGCCGGCCTCCTGTCTGCATGCCCCCTGTGGCCACCAGGCTCCGAGG GGCCGTGGTGACTCTTGATCAAAGAGCACAGTGAACTGTCCCTTCTGAGTCTCCCTTTTCTACAGTTGATATATTTGTAACTGGTACAAG ATGAAGGACAGCAGCTTTCCATCCCTAGTTCAGAGCCCCCGTTCCCCAGGGTCCTGTGGGCTGAGCGGCTGGGGCTGGGGCTGCCCACGT GTGGCCTCCGCTGGCTCTGCCTGCTCCTGCAACAGTGCGGTCCCTGCCCGGAGAACTCAGGAGGCCTGCAGAAGAGAACTGATTGGTGGT CGAAGCACCATCTTCACAGATGTTCAGGGGCAGTGGGGGGCTCCAGGCACGGTCAATGAAGGAAACAGTGCCTGTCCACCCACCCTGCGT GTCACTGTGGCGGCCTGGCTGTCGCTGCTTTTTGTCCTCTGCCGTGTTTGCGCGGCCTCAGTGCCCTCCCTGGTGCGTCTGCGCTGGGGC CCTCAGTGCTCGGGGCCTTGGGGTGCATGGGTGCCGCCCTGGGCAGCTAGAGTGTCTCAGCCCGGTGCTGGGCCTGGCCGAGGGGCGGAG GCACAGCTGCTTCCAGCAGCCAGCATTCAGTGGCCTTGTCACCAAGCTCCACACCTCCTCCTGGTGCTGGCTTTGGTGACATCACAAGGC CCCTCCAGGTGCAGGGGCTTCTGTTTGGCAGGCCCCTGCCAGGGAGGACCTGGTGGCCTCCTCATTCTCTTTTGCCATTGGAATGTCCCC TTGCAGTTCTCTTCTCTTTTTTTTTTTTTTTGAGATGGAGTTTCACTCTTGCTGCCCAGGCTGGAGTGCAGTGGCTCAATCTCGGGTCAC TGCAACCTCCGCCTCCCGGGTTCAAGTGATCGTCCTGCCTTAGGCTCCTGAGTAGCTGGGGATTACAGGTGCCTACCAGCATGCTCGGCT AATTTTTTTGTATTTTTAGTAGAGAAGGGATTTCACCATGTTGGCCGGGCTGGTCTCAAACTCCTAAGGTCATCCACCTGCCTCGGCCTC CCAGAGTGCTGAGATTACAGGCGTGAGCCTCCGCGCCCGGCCCCCTTGCAGTTCTCTCTGATTTGGTTTGTTCTGTCTCAGGCTTCTGTG GCAGGACTGGCCCAGGGAGGAGGAAGCCAGCAGCACACCTGGGGAATGGGGTCCCGGCCGGGAGGCTTGGCCTCTGGGCGACCTCGTCCT GTTTTTTTTGTTTGTTTGTTTGTTTTTTTAAAGGTAAACCTCCTGGGCCGCAGATGGCAAAGGGAGTGCCTGGGCCTGGTGACCCAGGGC TGGATCCACCCCTGCGGAGCCCTGGGCCAGGCAGGTGTCTGCTGCTCACCTGGCTCTGGAGGGCTGCCCTGCAGCTGGGCCTGGGGACAG GTCGGCTGTGGGGCAGCTCAGTACCCTCCCTGAGGCTCACGGTGGCTCCGAGCATGAGGTCCGCCTCCTGGGCGAGACCCAGCAGTGGAC AGCATGGTCCTCACACCCAGCTCCCTGCACACCCAGGCCAGCCACCCCTCCCGCTCGTGCACAGGCACGCAGATGCGCTCACACGTACAC ACACACAAATGCACGCCCACTTGCACATGCTCACGCACATGTTCACACATGCACACTCACGCTCACACATGCTGTCACGCATACACACAC GCACATACTCCTGCACATGTTCCCATGCATGTGTGTGCACTCGGACCGAGCATCTCCCACGCACCTCTACCCCACCCCAAGCACCTCTCT CCCCCCATGCACCTCTCCCCAACAACACACACAGCCCCCTGCACCGCCCGCCCCCCGCCCCCACCAAGGCCCCAGCCTCTGGCCATCAGT CCTGGTGCCAGAGCTTTGCGTGAAGTTCGGGCCGCAGAGTGGCCCGCTGGGACTCCCATGTGCTGCCGTCTGATGTGCTCAGATGGGCTC >54363_54363_2_MLYCD-MGRN1_MLYCD_chr16_83945972_ENST00000262430_MGRN1_chr16_4718266_ENST00000399577_length(amino acids)=647AA_BP=319 MLWGTMRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRA ELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDV REMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNI QAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETK PSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHS CPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAAIDHILDSSRQKGR PQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPAD -------------------------------------------------------------- >54363_54363_3_MLYCD-MGRN1_MLYCD_chr16_83945972_ENST00000262430_MGRN1_chr16_4718266_ENST00000415496_length(transcript)=6557nt_BP=967nt GCAGCTGTTGTGGGGCACCATGCGAGGCTTCGGGCCAGGCTTGACGGCCAGGCGTCTCCTCCCGCTGCGGTTGCCCCCGCGGCCGCCCGG GCCCCGGCTGGCGAGCGGGCAGGCGGCCGGCGCCCTGGAGCGGGCCATGGACGAGCTGCTGCGCCGCGCGGTGCCGCCGACGCCGGCCTA CGAGCTGCGCGAGAAGACACCGGCGCCCGCCGAGGGTCAGTGCGCGGACTTCGTGAGCTTCTACGGTGGGCTGGCCGAGACGGCCCAGCG GGCCGAACTGCTGGGCCGCCTGGCGCGGGGCTTCGGCGTGGACCACGGCCAGGTGGCGGAGCAGAGCGCCGGCGTGCTCCATCTGCGCCA GCAGCAGCGGGAGGCGGCGGTGCTGCTGCAGGCCGAGGACCGGCTGCGCTACGCGCTGGTGCCGCGCTATCGCGGCCTCTTCCACCACAT CAGCAAGCTGGACGGCGGCGTGCGCTTCCTGGTGCAGCTGCGGGCCGACCTGCTGGAGGCGCAGGCCCTCAAGCTGGTGGAGGGGCCGGA CGTCCGGGAAATGAATGGGGTGCTGAAAGGAATGCTCTCAGAATGGTTTTCCTCCGGGTTCCTGAACCTAGAACGGGTTACCTGGCATTC ACCGTGTGAAGTGCTTCAGAAAATCAGTGAGGCTGAGGCTGTGCATCCTGTAAAAAACTGGATGGACATGAAGCGCCGCGTTGGGCCCTA CAGAAGGTGTTACTTCTTTTCTCACTGTTCGACCCCTGGGGAGCCCCTGGTCGTTTTGCACGTGGCACTGACTGGTGACATCTCCAGCAA CATCCAGGCAATCGTGAAGGAACATCCTCCATCAGAAACAGAAGAGAAGAACAAAATCACTGCTGCGATCTTTTATTCCATCAGCTTGAC CCAGCAGGGACTCCAAGGGGTGGAGCTGGGAACATTCCTCATAAAGCGAGTCGTCAAGGAGTTGCAGCACATGGACGGCAGCTTCTCTGT GAAGCCTTTAAAGCAGAAGCAAATTGTGGACCGGGTCAGCTACCTCCTGCAGGAGATCTATGGCATTGAGAACAAGAACAACCAGGAGAC CAAGCCCTCGGACGACGAGAACAGCGACAACAGCAACGAGTGTGTGGTGTGCCTGTCCGACCTGCGGGACACGCTGATCCTGCCCTGCCG CCACCTGTGCCTCTGTACCTCCTGCGCCGACACGCTGCGCTACCAGGCCAACAACTGCCCCATCTGCCGGCTGCCTTTCCGGGCCCTCCT GCAGATCCGGGCGGTGCGGAAGAAGCCAGGAGCCCTGTCCCCCGTGTCCTTCAGCCCCGTCCTGGCCCAGAGCCTGGAGCATGATGAGCA CTCTAACTCTGACAGCGTCCCACCTGGCTACGAGCCCATCTCGCTGCTCGAGGCGCTCAACGGCCTCCGGGCTGTCTCCCCGGCCATCCC CTCGGCCCCTCTTTATGAAGAAATCACCTATTCAGGCATCTCGGACGGCCTGTCCCAGGCCAGCTGTCCCCTCGCGGCTATCGACCACAT CCTGGACAGCAGCCGCCAGAAGGGCAGGCCGCAGAGCAAGGCCCCCGACAGCACCCTACGGTCCCCGTCTTCCCCCATCCACGAAGAGGA TGAGGAGAAGCTCTCCGAGGACGTGGACGCCCCTCCCCCACTGGGTGGCGCAGAGCTGGCCCTGCGGGAAAGCAGCTCCCCTGAGAGTTT CATAACAGAAGAGGTTGATGAGTCGTCGTCACCACAGCAAGGGACCCGAGCAGCTTCCATTGAGAATGTCCTGCAGGACAGCAGCCCCGA GCACTGTGGCCGAGGCCCACCTGCTGACATCTACCTGCCAGCCCTGGGGCCCGACTCCTGCTCTGTTGGTATAGACGAGTAAGCCGGTAC GTGACCTCCCAGACGCGCTTCGGGGGCTCTGACGCGCGTCCTTGGAGAGAGGAGCCCTCCCCTGCTCTCTGGCGGGGGTTCCTTCTGGTT TTTGGGTCTTCGTCCGCATCCGCATCTTCCCAGGGGCCCTGGATTCCGAATCCAGAGCTCTCCAGTGGCTGCTGCACCTTCCCCCAGAAA GTGGCCTCCTGGGGGGTCCTGACTTTCGGGGCCAGAGGTCTCTCCATCTGGACTAGGCGGCCGGTCAGGCTCTTCTTCCAGCCTTGAGGG GCCCTGGAACAGTCCCAGCCCAGGCAGGGAGACAGACACAGCCCAGGTGCGCCAGAGCCACTGTCCACTGCGGGAGGCAGGAGCTTGAGG GATGAGGGCAGCACCGTGGAGGGAACCCCAGGGAGACATGGGGTGAGCGTCCCAAGGGGAGAGGCCTGGGCCTGGCCTTGTTCCGGATGG TCCCACCATGAGTTCGCATCGGTCCTGCAGCAGACACGTTAGGACGCTCAGCAGGTCCACTCCCGTGTTCCGGTCGTGGCTTTAACAATT CATGGGGAAAGAATGCGCCCCGATTGGGAGAGCCCCTGGATCACGTCTTCCCAAGCTCAGTCCCTGTCTCTTGGAGGGAGTCCGTCCTCG AGGGGCCCTCTGGTGCCCAGGGGAGAGTATCTTGCGTCCTGTCCTGAGGGCGTCCGCTCACACAGCCACCTGCTCCCCCGCTCCCTCCTT CCCTTGTCAGCATGGCCACCGTGGGCCTGGCATCACCATGGGCCTGGCACACAGTCCCTCGTGGGCTGCCTTTGTGCCATGAGCCCACTG CTGCCGACTCACCTGTCCCTCCCAGTACTGGAACCTTCTGGAACACCAGCACTAAAAGATAGGAGGCCCTGTGAGGTTGGCATCCCCCAT CCCCCCCAAGAGGCGCCCTCTACCAGGGTGGCCCAGGTGAGTGTTTTACAGAAGGCGGCTCTGTCCAGGCAGTGGTTCGCACCTATAAGC CCGGTACTTTGGGAGACCGAGGGGATAGATCACTTGAGCCCAGGAATTCAAGATCAGTGTAGAAAACATAGACCCCCTCTCTATGAAAAA TAAAAAATTGGCTTGGGCGTGGTAGCTTGTGCCTGTGGTCCCAGCTACTCAGGGGTGCTGAGGTGGGAGGATTGCCGGAGCTGGGGAGGT CAAGGCCCACTCCAGCCTGAGACGCTGTCTCAATAAAAAAAAATACACACACACCCACCCACCCACTCCAGCCTGAGACCCTGTCTCAAG AAAAAAAAAATACACACACACACACACACACACACACACACGGGGGAGAGAGAGAAGGCAGCTCCAGGAGTGCCACCAAAATGTAGGCAG ACGGATTGGGGACCCTCTGCCTTCCCAGAGGGTCTTGGCACACAAGCTGCGTGCAGCTCTGGTCTGCCGAGGCCCATGCAGCCTGCTGGG AGGTGCCTGGCCGGGGGTGCAGGCTCTAAGAGGCCCTTTCCCCTTGGGTGGACTTGAGCCGGGTCAGGGAGAACTTCGCTTCTTTTGACT GCGCTCTGCATTCCCATGAACCTCTGTCTTCTTGAGCCCAGCGAGTCCCTCTGTTGACCCCTGTCCTGAGCCATTATACCCCTAGATTGA AACAGTCAGCACCTTTCAGACGGCCCCGGCCTGCGCATCGGTGGAAGGTGCCGTGCGAATGTCACGATTCAGGTCAAGCTTCCGGAGCTG GGGAGTGCAGGTGTGATCTAGAACAGGGCTCACAGCCTCGGAAACCTGCTCTCGCCGCGGCCCCCGAAGAAAATAGACGCCCTTCACCGG AGAGTGGGGCCTGGGCCGTGTCTGCTGGGAGCCATGTGTCAGGGCTGGTGGCTGGGTGTCAGGCAGCCCTGAGGCCATGCTGGCCCCGTC CCAGGCTCTGCACCAGCACCATTGCCCAAGCCCCAGGGACGCCAGACCCATCTGGGGACAGCGCCCGGCGGCGTCGTGCAGGCCACAGTC TGGGCATTGGGGCTCTGTGGGAGGCTCCTCTCTTTGCCTTGCAGTAGCCATCCGGGGGCTACTCTGAGCACGGGCTTGTTCTCACCCAGG GCCGCTCCCCACCCCTGCACCCTGGGTTGACCGAGTTCCACCCTAACCCAGCCGTAAGAACCTTGGCAGGACAGTGGCTGGCCACATCCC AGGAAACCGGAACCAGGGCAAGGGCAGGAGGCCCAGAGGGCATCCACCGCGGTGCCGTGTCGCGCTCTGACTCGGGGCTGCAGATCTGCT GTGGGTGTCCGGGGATCTGGGATCGTCTGTCCCAAGAGGGACACAGCGTATTTGGCACAGTTAGGGAGTCCCCGGGCCCTTGGTGTGCTC ACATCTGAGTGAATGCTGTTGTGGCCACAGGCGGCGGGAGTGGGGGTGCTGGATGGCCCAGCCCCTCTGGGGCTCCAGATCGGTAGGAGC GGGTGGCGTGGCACCAGGCATCCGAGTGTGACCCTCCTCCCTCTGCTCCCACCTGCAGGACGGCCCACCTCCATGGAGACGGCCCACGGC CTCGCCACCACCAGCCCCACCTGGCCTCCACTTGGTGGCCCCAGCCCCGATCCCAGCGCCGCCGAGCTGACCCCACTCTGAGAGCCTGGC CGAGCTGGCAGCATGGAGCCCTCGGCTCCCCAGACTTTGCCGAGGGGCTGCTCCGGACCCCGTTGTGAGCCGGCCTCCTGTCTGCATGCC CCCTGTGGCCACCAGGCTCCGAGGGGCCGTGGTGACTCTTGATCAAAGAGCACAGTGAACTGTCCCTTCTGAGTCTCCCTTTTCTACAGT TGATATATTTGTAACTGGTACAAGATGAAGGACAGCAGCTTTCCATCCCTAGTTCAGAGCCCCCGTTCCCCAGGGTCCTGTGGGCTGAGC GGCTGGGGCTGGGGCTGCCCACGTGTGGCCTCCGCTGGCTCTGCCTGCTCCTGCAACAGTGCGGTCCCTGCCCGGAGAACTCAGGAGGCC TGCAGAAGAGAACTGATTGGTGGTCGAAGCACCATCTTCACAGATGTTCAGGGGCAGTGGGGGGCTCCAGGCACGGTCAATGAAGGAAAC AGTGCCTGTCCACCCACCCTGCGTGTCACTGTGGCGGCCTGGCTGTCGCTGCTTTTTGTCCTCTGCCGTGTTTGCGCGGCCTCAGTGCCC TCCCTGGTGCGTCTGCGCTGGGGCCCTCAGTGCTCGGGGCCTTGGGGTGCATGGGTGCCGCCCTGGGCAGCTAGAGTGTCTCAGCCCGGT GCTGGGCCTGGCCGAGGGGCGGAGGCACAGCTGCTTCCAGCAGCCAGCATTCAGTGGCCTTGTCACCAAGCTCCACACCTCCTCCTGGTG CTGGCTTTGGTGACATCACAAGGCCCCTCCAGGTGCAGGGGCTTCTGTTTGGCAGGCCCCTGCCAGGGAGGACCTGGTGGCCTCCTCATT CTCTTTTGCCATTGGAATGTCCCCTTGCAGTTCTCTTCTCTTTTTTTTTTTTTTTGAGATGGAGTTTCACTCTTGCTGCCCAGGCTGGAG TGCAGTGGCTCAATCTCGGGTCACTGCAACCTCCGCCTCCCGGGTTCAAGTGATCGTCCTGCCTTAGGCTCCTGAGTAGCTGGGGATTAC AGGTGCCTACCAGCATGCTCGGCTAATTTTTTTGTATTTTTAGTAGAGAAGGGATTTCACCATGTTGGCCGGGCTGGTCTCAAACTCCTA AGGTCATCCACCTGCCTCGGCCTCCCAGAGTGCTGAGATTACAGGCGTGAGCCTCCGCGCCCGGCCCCCTTGCAGTTCTCTCTGATTTGG TTTGTTCTGTCTCAGGCTTCTGTGGCAGGACTGGCCCAGGGAGGAGGAAGCCAGCAGCACACCTGGGGAATGGGGTCCCGGCCGGGAGGC TTGGCCTCTGGGCGACCTCGTCCTGTTTTTTTTGTTTGTTTGTTTGTTTTTTTAAAGGTAAACCTCCTGGGCCGCAGATGGCAAAGGGAG TGCCTGGGCCTGGTGACCCAGGGCTGGATCCACCCCTGCGGAGCCCTGGGCCAGGCAGGTGTCTGCTGCTCACCTGGCTCTGGAGGGCTG CCCTGCAGCTGGGCCTGGGGACAGGTCGGCTGTGGGGCAGCTCAGTACCCTCCCTGAGGCTCACGGTGGCTCCGAGCATGAGGTCCGCCT CCTGGGCGAGACCCAGCAGTGGACAGCATGGTCCTCACACCCAGCTCCCTGCACACCCAGGCCAGCCACCCCTCCCGCTCGTGCACAGGC ACGCAGATGCGCTCACACGTACACACACACAAATGCACGCCCACTTGCACATGCTCACGCACATGTTCACACATGCACACTCACGCTCAC ACATGCTGTCACGCATACACACACGCACATACTCCTGCACATGTTCCCATGCATGTGTGTGCACTCGGACCGAGCATCTCCCACGCACCT CTACCCCACCCCAAGCACCTCTCTCCCCCCATGCACCTCTCCCCAACAACACACACAGCCCCCTGCACCGCCCGCCCCCCGCCCCCACCA AGGCCCCAGCCTCTGGCCATCAGTCCTGGTGCCAGAGCTTTGCGTGAAGTTCGGGCCGCAGAGTGGCCCGCTGGGACTCCCATGTGCTGC >54363_54363_3_MLYCD-MGRN1_MLYCD_chr16_83945972_ENST00000262430_MGRN1_chr16_4718266_ENST00000415496_length(amino acids)=625AA_BP=319 MLWGTMRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRA ELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDV REMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNI QAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETK PSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHS NSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDE -------------------------------------------------------------- >54363_54363_4_MLYCD-MGRN1_MLYCD_chr16_83945972_ENST00000262430_MGRN1_chr16_4718266_ENST00000586183_length(transcript)=2130nt_BP=967nt GCAGCTGTTGTGGGGCACCATGCGAGGCTTCGGGCCAGGCTTGACGGCCAGGCGTCTCCTCCCGCTGCGGTTGCCCCCGCGGCCGCCCGG GCCCCGGCTGGCGAGCGGGCAGGCGGCCGGCGCCCTGGAGCGGGCCATGGACGAGCTGCTGCGCCGCGCGGTGCCGCCGACGCCGGCCTA CGAGCTGCGCGAGAAGACACCGGCGCCCGCCGAGGGTCAGTGCGCGGACTTCGTGAGCTTCTACGGTGGGCTGGCCGAGACGGCCCAGCG GGCCGAACTGCTGGGCCGCCTGGCGCGGGGCTTCGGCGTGGACCACGGCCAGGTGGCGGAGCAGAGCGCCGGCGTGCTCCATCTGCGCCA GCAGCAGCGGGAGGCGGCGGTGCTGCTGCAGGCCGAGGACCGGCTGCGCTACGCGCTGGTGCCGCGCTATCGCGGCCTCTTCCACCACAT CAGCAAGCTGGACGGCGGCGTGCGCTTCCTGGTGCAGCTGCGGGCCGACCTGCTGGAGGCGCAGGCCCTCAAGCTGGTGGAGGGGCCGGA CGTCCGGGAAATGAATGGGGTGCTGAAAGGAATGCTCTCAGAATGGTTTTCCTCCGGGTTCCTGAACCTAGAACGGGTTACCTGGCATTC ACCGTGTGAAGTGCTTCAGAAAATCAGTGAGGCTGAGGCTGTGCATCCTGTAAAAAACTGGATGGACATGAAGCGCCGCGTTGGGCCCTA CAGAAGGTGTTACTTCTTTTCTCACTGTTCGACCCCTGGGGAGCCCCTGGTCGTTTTGCACGTGGCACTGACTGGTGACATCTCCAGCAA CATCCAGGCAATCGTGAAGGAACATCCTCCATCAGAAACAGAAGAGAAGAACAAAATCACTGCTGCGATCTTTTATTCCATCAGCTTGAC CCAGCAGGGACTCCAAGGGGTGGAGCTGGGAACATTCCTCATAAAGCGAGTCGTCAAGGAGTTGCAGCACATGGACGGCAGCTTCTCTGT GAAGCCTTTAAAGCAGAAGCAAATTGTGGACCGGGTCAGCTACCTCCTGCAGGAGATCTATGGCATTGAGAACAAGAACAACCAGGAGAC CAAGCCCTCGGACGACGAGAACAGCGACAACAGCAACGAGTGTGTGGTGTGCCTGTCCGACCTGCGGGACACGCTGATCCTGCCCTGCCG CCACCTGTGCCTCTGTACCTCCTGCGCCGACACGCTGCGCTACCAGGCCAACAACTGCCCCATCTGCCGGCTGCCTTTCCGGGCCCTCCT GCAGATCCGGGCGGTGCGGAAGAAGCCAGGAGCCCTGTCCCCCGTGTCCTTCAGCCCCGTCCTGGCCCAGAGCCTGGAGCATGATGAGCA CTCTAACTCTGACAGCGTCCCACCTGGCTACGAGCCCATCTCGCTGCTCGAGGCGCTCAACGGCCTCCGGGCTGTCTCCCCGGCCATCCC CTCGGCCCCTCTTTATGAAGAAATCACCTATTCAGGCATCTCGGACGGCCTGTCCCAGGCCAGCTGTCCCCTCGCGGCTATCGACCACAT CCTGGACAGCAGCCGCCAGAAGGGCAGGCCGCAGAGCAAGGCCCCCGACAGCACCCTACGGTCCCCGTCTTCCCCCATCCACGAAGAGGA TGAGGAGAAGCTCTCCGAGGACGTGGACGCCCCTCCCCCACTGGGTGGCGCAGAGCTGGCCCTGCGGGAAAGCAGCTCCCCTGAGAGTTT CATAACAGAAGAGGTTGATGAGTCGTCGTCACCACAGCAAGGGACCCGAGCAGCTTCCATTGAGAATGTCCTGCAGGACAGCAGCCCCGA GCACTGTGGCCGAGGCCCACCTGCTGACATCTACCTGCCAGCCCTGGGGCCCGACTCCTGCTCTGTTGGTATAGACGAGTAAGCCGGACG GCCCACCTCCATGGAGACGGCCCACGGCCTCGCCACCACCAGCCCCACCTGGCCTCCACTTGGTGGCCCCAGCCCCGATCCCAGCGCCGC CGAGCTGACCCCACTCTGAGAGCCTGGCCGAGCTGGCAGCATGGAGCCCTCGGCTCCCCAGACTTTGCCGAGGGGCTGCTCCGGACCCCG >54363_54363_4_MLYCD-MGRN1_MLYCD_chr16_83945972_ENST00000262430_MGRN1_chr16_4718266_ENST00000586183_length(amino acids)=625AA_BP=319 MLWGTMRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRA ELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDV REMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNI QAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETK PSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHS NSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDE -------------------------------------------------------------- >54363_54363_5_MLYCD-MGRN1_MLYCD_chr16_83945972_ENST00000262430_MGRN1_chr16_4718266_ENST00000588994_length(transcript)=1954nt_BP=967nt GCAGCTGTTGTGGGGCACCATGCGAGGCTTCGGGCCAGGCTTGACGGCCAGGCGTCTCCTCCCGCTGCGGTTGCCCCCGCGGCCGCCCGG GCCCCGGCTGGCGAGCGGGCAGGCGGCCGGCGCCCTGGAGCGGGCCATGGACGAGCTGCTGCGCCGCGCGGTGCCGCCGACGCCGGCCTA CGAGCTGCGCGAGAAGACACCGGCGCCCGCCGAGGGTCAGTGCGCGGACTTCGTGAGCTTCTACGGTGGGCTGGCCGAGACGGCCCAGCG GGCCGAACTGCTGGGCCGCCTGGCGCGGGGCTTCGGCGTGGACCACGGCCAGGTGGCGGAGCAGAGCGCCGGCGTGCTCCATCTGCGCCA GCAGCAGCGGGAGGCGGCGGTGCTGCTGCAGGCCGAGGACCGGCTGCGCTACGCGCTGGTGCCGCGCTATCGCGGCCTCTTCCACCACAT CAGCAAGCTGGACGGCGGCGTGCGCTTCCTGGTGCAGCTGCGGGCCGACCTGCTGGAGGCGCAGGCCCTCAAGCTGGTGGAGGGGCCGGA CGTCCGGGAAATGAATGGGGTGCTGAAAGGAATGCTCTCAGAATGGTTTTCCTCCGGGTTCCTGAACCTAGAACGGGTTACCTGGCATTC ACCGTGTGAAGTGCTTCAGAAAATCAGTGAGGCTGAGGCTGTGCATCCTGTAAAAAACTGGATGGACATGAAGCGCCGCGTTGGGCCCTA CAGAAGGTGTTACTTCTTTTCTCACTGTTCGACCCCTGGGGAGCCCCTGGTCGTTTTGCACGTGGCACTGACTGGTGACATCTCCAGCAA CATCCAGGCAATCGTGAAGGAACATCCTCCATCAGAAACAGAAGAGAAGAACAAAATCACTGCTGCGATCTTTTATTCCATCAGCTTGAC CCAGCAGGGACTCCAAGGGGTGGAGCTGGGAACATTCCTCATAAAGCGAGTCGTCAAGGAGTTGCAGCACATGGACGGCAGCTTCTCTGT GAAGCCTTTAAAGCAGAAGCAAATTGTGGACCGGGTCAGCTACCTCCTGCAGGAGATCTATGGCATTGAGAACAAGAACAACCAGGAGAC CAAGCCCTCGGACGACGAGAACAGCGACAACAGCAACGAGTGTGTGGTGTGCCTGTCCGACCTGCGGGACACGCTGATCCTGCCCTGCCG CCACCTGTGCCTCTGTACCTCCTGCGCCGACACGCTGCGCTACCAGGCCAACAACTGCCCCATCTGCCGGCTGCCTTTCCGGGCCCTCCT GCAGATCCGGGCGGTGCGGAAGAAGCCAGGAGCCCTGTCCCCCGTGTCCTTCAGCCCCGTCCTGGCCCAGAGCCTGGAGCATGATGAGCA CTCTAACTCTGACAGCGTCCCACCTGGCTACGAGCCCATCTCGCTGCTCGAGGCGCTCAACGGCCTCCGGGCTGTCTCCCCGGCCATCCC CTCGGCCCCTCTTTATGAAGAAATCACCTATTCAGGCATCTCGGACGGCCTGTCCCAGGCCAGCTGTCCCCTCGCGGCTATCGACCACAT CCTGGACAGCAGCCGCCAGAAGGGCAGGCCGCAGAGCAAGGCCCCCGACAGCACCCTACGGTCCCCGTCTTCCCCCATCCACGAAGAGGA TGAGGAGAAGCTCTCCGAGGACGTGGACGCCCCTCCCCCACTGGGTGGCGCAGAGCTGGCCCTGCGGGAAAGCAGCTCCCCTGAGAGTTT CATAACAGAAGAGGTTGATGAGTCGTCGTCACCACAGCAAGGGACCCGAGCAGCTTCCATTGAGAATGTCCTGCAGGACAGCAGCCCCGA GCACTGTGGCCGAGGCCCACCTGCTGACATCTACCTGCCAGGACGGCCCACCTCCATGGAGACGGCCCACGGCCTCGCCACCACCAGCCC >54363_54363_5_MLYCD-MGRN1_MLYCD_chr16_83945972_ENST00000262430_MGRN1_chr16_4718266_ENST00000588994_length(amino acids)=650AA_BP=319 MLWGTMRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRA ELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDV REMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNI QAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETK PSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHS NSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDE EKLSEDVDAPPPLGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPGRPTSMETAHGLATTSPT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MLYCD-MGRN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MLYCD-MGRN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MLYCD-MGRN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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