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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MMP11-GAS2L1 (FusionGDB2 ID:54394)

Fusion Gene Summary for MMP11-GAS2L1

check button Fusion gene summary
Fusion gene informationFusion gene name: MMP11-GAS2L1
Fusion gene ID: 54394
HgeneTgene
Gene symbol

MMP11

GAS2L1

Gene ID

4320

10634

Gene namematrix metallopeptidase 11growth arrest specific 2 like 1
SynonymsSL-3|ST3|STMY3GAR22
Cytomap

22q11.23

22q12.2

Type of geneprotein-codingprotein-coding
Descriptionstromelysin-3matrix metallopeptidase 11 (stromelysin 3)stromelysin IIIGAS2-like protein 1GAS2-related protein on chromosome 22epididymis secretory sperm binding proteingrowth arrest-specific protein 2-like 1
Modification date2020031320200313
UniProtAcc

P24347

Q99501

Ensembl transtripts involved in fusion geneENST00000215743, ENST00000477567, 
ENST00000341313, ENST00000360113, 
ENST00000403764, ENST00000406549, 
ENST00000407647, ENST00000407854, 
ENST00000471961, 
Fusion gene scores* DoF score3 X 3 X 3=271 X 1 X 1=1
# samples 31
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: MMP11 [Title/Abstract] AND GAS2L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMMP11(24115165)-GAS2L1(29706429), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGAS2L1

GO:0097067

cellular response to thyroid hormone stimulus

19375645

TgeneGAS2L1

GO:1904825

protein localization to microtubule plus-end

24706950


check buttonFusion gene breakpoints across MMP11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GAS2L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-V1-A8WN-01AMMP11chr22

24115165

-GAS2L1chr22

29706429

+
ChimerDB4PRADTCGA-V1-A8WN-01AMMP11chr22

24115165

+GAS2L1chr22

29706429

+
ChimerDB4PRADTCGA-V1-A8WNMMP11chr22

24115165

+GAS2L1chr22

29706429

+


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Fusion Gene ORF analysis for MMP11-GAS2L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000215743ENST00000341313MMP11chr22

24115165

+GAS2L1chr22

29706429

+
In-frameENST00000215743ENST00000360113MMP11chr22

24115165

+GAS2L1chr22

29706429

+
In-frameENST00000215743ENST00000403764MMP11chr22

24115165

+GAS2L1chr22

29706429

+
In-frameENST00000215743ENST00000406549MMP11chr22

24115165

+GAS2L1chr22

29706429

+
In-frameENST00000215743ENST00000407647MMP11chr22

24115165

+GAS2L1chr22

29706429

+
In-frameENST00000215743ENST00000407854MMP11chr22

24115165

+GAS2L1chr22

29706429

+
In-frameENST00000215743ENST00000471961MMP11chr22

24115165

+GAS2L1chr22

29706429

+
intron-3CDSENST00000477567ENST00000341313MMP11chr22

24115165

+GAS2L1chr22

29706429

+
intron-3CDSENST00000477567ENST00000360113MMP11chr22

24115165

+GAS2L1chr22

29706429

+
intron-3CDSENST00000477567ENST00000403764MMP11chr22

24115165

+GAS2L1chr22

29706429

+
intron-3CDSENST00000477567ENST00000406549MMP11chr22

24115165

+GAS2L1chr22

29706429

+
intron-3CDSENST00000477567ENST00000407647MMP11chr22

24115165

+GAS2L1chr22

29706429

+
intron-3CDSENST00000477567ENST00000407854MMP11chr22

24115165

+GAS2L1chr22

29706429

+
intron-3CDSENST00000477567ENST00000471961MMP11chr22

24115165

+GAS2L1chr22

29706429

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000215743MMP11chr2224115165+ENST00000407647GAS2L1chr2229706429+1860160521140362
ENST00000215743MMP11chr2224115165+ENST00000360113GAS2L1chr2229706429+16851605541399281
ENST00000215743MMP11chr2224115165+ENST00000406549GAS2L1chr2229706429+118016052891279
ENST00000215743MMP11chr2224115165+ENST00000341313GAS2L1chr2229706429+16321606681603311
ENST00000215743MMP11chr2224115165+ENST00000403764GAS2L1chr2229706429+1860160521140362
ENST00000215743MMP11chr2224115165+ENST00000407854GAS2L1chr2229706429+1860160521140362
ENST00000215743MMP11chr2224115165+ENST00000471961GAS2L1chr2229706429+1860160521140362

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000215743ENST00000407647MMP11chr2224115165+GAS2L1chr2229706429+0.453569860.5464301
ENST00000215743ENST00000360113MMP11chr2224115165+GAS2L1chr2229706429+0.213721440.7862786
ENST00000215743ENST00000406549MMP11chr2224115165+GAS2L1chr2229706429+0.51514650.48485357
ENST00000215743ENST00000341313MMP11chr2224115165+GAS2L1chr2229706429+0.553328160.44667184
ENST00000215743ENST00000403764MMP11chr2224115165+GAS2L1chr2229706429+0.453569860.5464301
ENST00000215743ENST00000407854MMP11chr2224115165+GAS2L1chr2229706429+0.453569860.5464301
ENST00000215743ENST00000471961MMP11chr2224115165+GAS2L1chr2229706429+0.453569860.5464301

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Fusion Genomic Features for MMP11-GAS2L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MMP11-GAS2L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:24115165/chr22:29706429)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MMP11

P24347

GAS2L1

Q99501

FUNCTION: May play an important role in the progression of epithelial malignancies.FUNCTION: Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMMP11chr22:24115165chr22:29706429ENST00000215743+1878_8536489.0MotifCysteine switch
HgeneMMP11chr22:24115165chr22:29706429ENST00000215743+18291_33936489.0RepeatNote=Hemopexin 1
HgeneMMP11chr22:24115165chr22:29706429ENST00000215743+18340_38236489.0RepeatNote=Hemopexin 2
HgeneMMP11chr22:24115165chr22:29706429ENST00000215743+18384_43236489.0RepeatNote=Hemopexin 3
HgeneMMP11chr22:24115165chr22:29706429ENST00000215743+18433_48036489.0RepeatNote=Hemopexin 4
TgeneGAS2L1chr22:24115165chr22:29706429ENST0000034131315203_275211338.0DomainGAR
TgeneGAS2L1chr22:24115165chr22:29706429ENST000003413131527_148211338.0DomainCalponin-homology (CH)
TgeneGAS2L1chr22:24115165chr22:29706429ENST0000036011315203_275211330.0DomainGAR
TgeneGAS2L1chr22:24115165chr22:29706429ENST000003601131527_148211330.0DomainCalponin-homology (CH)


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Fusion Gene Sequence for MMP11-GAS2L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54394_54394_1_MMP11-GAS2L1_MMP11_chr22_24115165_ENST00000215743_GAS2L1_chr22_29706429_ENST00000341313_length(transcript)=1632nt_BP=160nt
ATAAGGGGCGGCGGCCCGGAGCGGCCCAGCAAGCCCAGCAGCCCCGGGGCGGATGGCTCCGGCCGCCTGGCTCCGCAGCGCGGCCGCGCG
CGCCCTCCTGCCCCCGATGCTGCTGCTGCTGCTCCAGCCGCCGCCGCTGCTGGCCCGGGCTCTGCCGCCGGTGAGGGAGATTCTGGGCCG
CTGCACCTGCCCTGACCAGTTTCCCATGATCAAGGTCTCAGAGGGGAAGTACCGTGTGGGGGACTCGAGCCTGCTCATCTTTGTGCGGGT
GCTGAGGAGCCACGTGATGGTGCGAGTGGGTGGTGGCTGGGACACGCTGGAGCATTACCTGGACAAGCACGACCCGTGCCGCTGCTCCTC
CACTGCTCATCGCCCACCCCAGCCGAGGGTCTGCACCTTTTCTCCACAGAGGGTGTCGCCCACCACCAGTCCCCGCCCTGCTAGCCCAGT
CCCTGGGAGTGAGCGCCGGGGCTCCCGGCCTGAGATGACTCCCGTTAGCTTACGAAGCACAAAGGAGGGGCCCGAGACCCCACCCAGGTG
AGATGCAGGAGGACGAGGAGTGAGGGGTCCAGAGGGTGGGGGGGCGTCAGCCCTGGCCTGCATGATGGGTTGCCTGTGCGCCAGAGTGAC
TCACACCCTGGGAAAAGTTCCCGTGGGTGGGGGCGGGCCTGGCTTCCCATCTCCATGGCAACCCAACCAAACCAACAACACAGCTGGGGC
GGGCCCTGTGGCTGGGCGGCAGCCAGTCCAGCTCTTGCTTCCTCTGGCCCGTCCTGGGAAGGGGGGTGTCTAGAGCCCAGGAAACTTCTT
CTTCCGTGGCTTTTGGGGCCCTGGGCCGCTGGAGGAAGCTGCTCACTTCTCCCTGGAAGTCCCCAGGACAGACCGATGCCCCTGACAGCC
CCGTCCACCAGCCACATACCCTGCTGTTCCTCTCCCTGCCTGTTCTGCATGCCAGTCCTTCCGTGGTACCCCATCTGTCTCTATTGTCCC
CCTGCCCCAGGCCCCGGGATCAGCTGCCCCCCCATCCCCGCTCCCGCCGCTACTCCGGGGACAGTGACTCCTCAGCCTCCTCCGCCCAGA
GCGGCCCCCTTGGTACCCGCAGTGATGACACAGGCACTGGCCCCCGGAGGGAGCGACCCAGCCGGCGGCTGACCACAGGCACCCCGGCCT
CTCCGAGACGGCCTCCTGCCTGCGCAGCCAGTCCCGAGACCGGCTGGATCGCGGCCGGCCCCGGGGGGCCCCAGGAGGCAGGGGAGCCCA
GCTGTCGGTCCCCAGCCCTGCCCGGCGGGCCCGGAGCCAGAGCCGCGAGGAGCAGGCTGTGCTGCTTGTGCGCAGGGATCGAGACGGGCA
GCACTCATGGGTGCCAAGGGGCAGGGGCAGTGGGGGCTCGGGCAGGAGCACCCCCCAGACTCCCCGTGCCCGCAGCCCTGCAGCACCCCG
GCTTTCCCGGGTCTCCAGCCCCAGTCCAGAGTTGGGCACCACACCGGCCAGCATCTTCCGCACACCCCTGCAGCTCGACCCGCAGCAGGA
GCAGCAGCTGTTCCGGCGCCTGGAAGAGGAGTTCCTGGCCAATGCCCGGGCCCTTGAGGCTGTTGCTAGCGTGACCCCCACTGGACCAGC

>54394_54394_1_MMP11-GAS2L1_MMP11_chr22_24115165_ENST00000215743_GAS2L1_chr22_29706429_ENST00000341313_length(amino acids)=311AA_BP=
MASHLHGNPTKPTTQLGRALWLGGSQSSSCFLWPVLGRGVSRAQETSSSVAFGALGRWRKLLTSPWKSPGQTDAPDSPVHQPHTLLFLSL
PVLHASPSVVPHLSLLSPCPRPRDQLPPHPRSRRYSGDSDSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPACAASPE
TGWIAAGPGGPQEAGEPSCRSPALPGGPGARAARSRLCCLCAGIETGSTHGCQGAGAVGARAGAPPRLPVPAALQHPGFPGSPAPVQSWA

--------------------------------------------------------------
>54394_54394_2_MMP11-GAS2L1_MMP11_chr22_24115165_ENST00000215743_GAS2L1_chr22_29706429_ENST00000360113_length(transcript)=1685nt_BP=160nt
ATAAGGGGCGGCGGCCCGGAGCGGCCCAGCAAGCCCAGCAGCCCCGGGGCGGATGGCTCCGGCCGCCTGGCTCCGCAGCGCGGCCGCGCG
CGCCCTCCTGCCCCCGATGCTGCTGCTGCTGCTCCAGCCGCCGCCGCTGCTGGCCCGGGCTCTGCCGCCGGTGAGGGAGATTCTGGGCCG
CTGCACCTGCCCTGACCAGTTTCCCATGATCAAGGTCTCAGAGGGGAAGTACCGTGTGGGGGACTCGAGCCTGCTCATCTTTGTGCGGGT
GCTGAGGAGCCACGTGATGGTGCGAGTGGGTGGTGGCTGGGACACGCTGGAGCATTACCTGGACAAGCACGACCCGTGCCGCTGCTCCTC
CACTGGCCCCGGGATCAGCTGCCCCCCCATCCCCGCTCCCGCCGCTACTCCGGGGACAGTGACTCCTCAGCCTCCTCCGCCCAGAGCGGC
CCCCTTGGTACCCGCAGTGATGACACAGGCACTGGCCCCCGGAGGGAGCGACCCAGCCGGCGGCTGACCACAGGCACCCCGGCCTCTCCG
AGACGGCCTCCTGCCTGCGCAGCCAGTCCCGAGACCGGCTGGATCGCGGCCGGCCCCGGGGGGCCCCAGGAGGCAGGGGAGCCCAGCTGT
CGGTCCCCAGCCCTGCCCGGCGGGCCCGGAGCCAGAGCCGCGAGGAGCAGGCTGTGCTGCTTGTGCGCAGGGATCGAGACGGGCAGCACT
CATGGGTGCCAAGGGGCAGGGGCAGTGGGGGCTCGGGCAGGAGCACCCCCCAGACTCCCCGTGCCCGCAGCCCTGCAGCACCCCGGCTTT
CCCGGGTCTCCAGCCCCAGTCCAGAGTTGGGCACCACACCGGCCAGCATCTTCCGCACACCCCTGCAGCTCGACCCGCAGCAGGAGCAGC
AGCTGTTCCGGCGCCTGGAAGAGGAGTTCCTGGCCAATGCCCGGGCCCTTGAGGCTGTTGCTAGCGTGACCCCCACTGGACCAGCCCCTG
ACCCAGCTCGGGCCCCCGACCCTCCAGCTCCTGACTCTGCCTATTGTTCCTCCAGTTCCTCCTCTTCGTCCCTCAGCGTCCTGGGTGGCA
AATGTGGCCAACCTGGGGACTCTGGCCGGACGGCCAATGGGCTGCCTGGGCCCCGAAGCCAAGCCCTTTCCAGCTCCTCCGATGAAGGCA
GCCCCTGCCCTGGCATGGGGGGGCCACTAGATGCACCTGGGAGCCCCCTGGCTTGCACTGAACCCTCGAGGACCTGGGCACGGGGTCGGA
TGGACACACAGCCAGACCGTAAACCCTCACGTATCCCCACGCCTCGGGGCCCCCGCCGCCCCTCCGGACCCGCAGAGCTGGGGACATGGC
ATGCCCTGCACTCAGTCACCCCGAGGGCTGAGCCAGATTCCTGGATGTGATGGACCAGCTCAGCTGTCCCCAGACCCCATCCCTTCTCCT
TTTCCTTTGTGGCCTTAACCCTTCTGCATCAGGGAGCCCCCTCTGCCTCTTGAGTACCAGACCTCATGGGACCAGACCCCTTGGGACCAC
ATGGCACAATGGGACCTCTGTTGTACATTCCGGTTGGGGGATGAGCGTTGCTATTTAATTACTAATATTATTGAATGCCTTAGAGGAGGC

>54394_54394_2_MMP11-GAS2L1_MMP11_chr22_24115165_ENST00000215743_GAS2L1_chr22_29706429_ENST00000360113_length(amino acids)=281AA_BP=
MRSQSRDRLDRGRPRGAPGGRGAQLSVPSPARRARSQSREEQAVLLVRRDRDGQHSWVPRGRGSGGSGRSTPQTPRARSPAAPRLSRVSS
PSPELGTTPASIFRTPLQLDPQQEQQLFRRLEEEFLANARALEAVASVTPTGPAPDPARAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQP
GDSGRTANGLPGPRSQALSSSSDEGSPCPGMGGPLDAPGSPLACTEPSRTWARGRMDTQPDRKPSRIPTPRGPRRPSGPAELGTWHALHS

--------------------------------------------------------------
>54394_54394_3_MMP11-GAS2L1_MMP11_chr22_24115165_ENST00000215743_GAS2L1_chr22_29706429_ENST00000403764_length(transcript)=1860nt_BP=160nt
ATAAGGGGCGGCGGCCCGGAGCGGCCCAGCAAGCCCAGCAGCCCCGGGGCGGATGGCTCCGGCCGCCTGGCTCCGCAGCGCGGCCGCGCG
CGCCCTCCTGCCCCCGATGCTGCTGCTGCTGCTCCAGCCGCCGCCGCTGCTGGCCCGGGCTCTGCCGCCGGTGAGGGAGATTCTGGGCCG
CTGCACCTGCCCTGACCAGTTTCCCATGATCAAGGTCTCAGAGGGGAAGTACCGTGTGGGGGACTCGAGCCTGCTCATCTTTGTGCGGGT
GCTGAGGAGCCACGTGATGGTGCGAGTGGGTGGTGGCTGGGACACGCTGGAGCATTACCTGGACAAGCACGACCCGTGCCGCTGCTCCTC
CACTGCTCATCGCCCACCCCAGCCGAGGGTCTGCACCTTTTCTCCACAGAGGGTGTCGCCCACCACCAGTCCCCGCCCTGCTAGCCCAGT
CCCTGGGAGTGAGCGCCGGGGCTCCCGGCCTGAGATGACTCCCGTTAGCTTACGAAGCACAAAGGAGGGGCCCGAGACCCCACCCAGGCC
CCGGGATCAGCTGCCCCCCCATCCCCGCTCCCGCCGCTACTCCGGGGACAGTGACTCCTCAGCCTCCTCCGCCCAGAGCGGCCCCCTTGG
TACCCGCAGTGATGACACAGGCACTGGCCCCCGGAGGGAGCGACCCAGCCGGCGGCTGACCACAGGCACCCCGGCCTCTCCGAGACGGCC
TCCTGCCTGCGCAGCCAGTCCCGAGACCGGCTGGATCGCGGCCGGCCCCGGGGGGCCCCAGGAGGCAGGGGAGCCCAGCTGTCGGTCCCC
AGCCCTGCCCGGCGGGCCCGGAGCCAGAGCCGCGAGGAGCAGGCTGTGCTGCTTGTGCGCAGGGATCGAGACGGGCAGCACTCATGGGTG
CCAAGGGGCAGGGGCAGTGGGGGCTCGGGCAGGAGCACCCCCCAGACTCCCCGTGCCCGCAGCCCTGCAGCACCCCGGCTTTCCCGGGTC
TCCAGCCCCAGTCCAGAGTTGGGCACCACACCGGCCAGCATCTTCCGCACACCCCTGCAGCTCGACCCGCAGCAGGAGCAGCAGCTGTTC
CGGCGCCTGGAAGAGGAGTTCCTGGCCAATGCCCGGGCCCTTGAGGCTGTTGCTAGCGTGACCCCCACTGGACCAGCCCCTGACCCAGCT
CGGGCCCCCGACCCTCCAGCTCCTGACTCTGCCTATTGTTCCTCCAGTTCCTCCTCTTCGTCCCTCAGCGTCCTGGGTGGCAAATGTGGC
CAACCTGGGGACTCTGGCCGGACGGCCAATGGGCTGCCTGGGCCCCGAAGCCAAGCCCTTTCCAGCTCCTCCGATGAAGGCAGCCCCTGC
CCTGGCATGGGGGGGCCACTAGATGCACCTGGGAGCCCCCTGGCTTGCACTGAACCCTCGAGGACCTGGGCACGGGGTCGGATGGACACA
CAGCCAGACCGTAAACCCTCACGTATCCCCACGCCTCGGGGCCCCCGCCGCCCCTCCGGACCCGCAGAGCTGGGGACATGGCATGCCCTG
CACTCAGTCACCCCGAGGGCTGAGCCAGATTCCTGGATGTGATGGACCAGCTCAGCTGTCCCCAGACCCCATCCCTTCTCCTTTTCCTTT
GTGGCCTTAACCCTTCTGCATCAGGGAGCCCCCTCTGCCTCTTGAGTACCAGACCTCATGGGACCAGACCCCTTGGGACCACATGGCACA
ATGGGACCTCTGTTGTACATTCCGGTTGGGGGATGAGCGTTGCTATTTAATTACTAATATTATTGAATGCCTTAGAGGAGGCCGGGCGAG

>54394_54394_3_MMP11-GAS2L1_MMP11_chr22_24115165_ENST00000215743_GAS2L1_chr22_29706429_ENST00000403764_length(amino acids)=362AA_BP=34
MAPAAWLRSAAARALLPPMLLLLLQPPPLLARALPPVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLE
HYLDKHDPCRCSSTAHRPPQPRVCTFSPQRVSPTTSPRPASPVPGSERRGSRPEMTPVSLRSTKEGPETPPRPRDQLPPHPRSRRYSGDS
DSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPACAASPETGWIAAGPGGPQEAGEPSCRSPALPGGPGARAARSRLCC
LCAGIETGSTHGCQGAGAVGARAGAPPRLPVPAALQHPGFPGSPAPVQSWAPHRPASSAHPCSSTRSRSSSCSGAWKRSSWPMPGPLRLL

--------------------------------------------------------------
>54394_54394_4_MMP11-GAS2L1_MMP11_chr22_24115165_ENST00000215743_GAS2L1_chr22_29706429_ENST00000406549_length(transcript)=1180nt_BP=160nt
ATAAGGGGCGGCGGCCCGGAGCGGCCCAGCAAGCCCAGCAGCCCCGGGGCGGATGGCTCCGGCCGCCTGGCTCCGCAGCGCGGCCGCGCG
CGCCCTCCTGCCCCCGATGCTGCTGCTGCTGCTCCAGCCGCCGCCGCTGCTGGCCCGGGCTCTGCCGCCGGTGAGGGAGATTCTGGGCCG
CTGCACCTGCCCTGACCAGTTTCCCATGATCAAGGTCTCAGAGGGGAAGTACCGTGTGGGGGACTCGAGCCTGCTCATCTTTGTGCGGGT
GCTGAGGAGCCACGTGATGGTGCGAGTGGGTGGTGGCTGGGACACGCTGGAGCATTACCTGGACAAGCACGACCCGTGCCGCTGCTCCTC
CACTGCTCATCGCCCACCCCAGCCGAGGGTCTGCACCTTTTCTCCACAGAGGGTGTCGCCCACCACCAGTCCCCGCCCTGCTAGCCCAGT
CCCTGGGAGTGAGCGCCGGGGCTCCCGGCCTGAGATGACTCCCGTTAGCTTACGAAGCACAAAGGAGGGGCCCGAGACCCCACCCAGTTC
CTCCTCTTCGTCCCTCAGCGTCCTGGGTGGCAAATGTGGCCAACCTGGGGACTCTGGCCGGACGGCCAATGGGCTGCCTGGGCCCCGAAG
CCAAGCCCTTTCCAGCTCCTCCGATGAAGGCAGCCCCTGCCCTGGCATGGGGGGGCCACTAGATGCACCTGGGAGCCCCCTGGCTTGCAC
TGAACCCTCGAGGACCTGGGCACGGGGTCGGATGGACACACAGCCAGACCGTAAACCCTCACGTATCCCCACGCCTCGGGGCCCCCGCCG
CCCCTCCGGACCCGCAGAGCTGGGGACATGGCATGCCCTGCACTCAGTCACCCCGAGGGCTGAGCCAGATTCCTGGATGTGATGGACCAG
CTCAGCTGTCCCCAGACCCCATCCCTTCTCCTTTTCCTTTGTGGCCTTAACCCTTCTGCATCAGGGAGCCCCCTCTGCCTCTTGAGTACC
AGACCTCATGGGACCAGACCCCTTGGGACCACATGGCACAATGGGACCTCTGTTGTACATTCCGGTTGGGGGATGAGCGTTGCTATTTAA
TTACTAATATTATTGAATGCCTTAGAGGAGGCCGGGCGAGCCCGGTGTTCTGAAGACCTGTGGCCCAGCAGAGCCTCTGACAGTAAAGTT

>54394_54394_4_MMP11-GAS2L1_MMP11_chr22_24115165_ENST00000215743_GAS2L1_chr22_29706429_ENST00000406549_length(amino acids)=279AA_BP=34
MAPAAWLRSAAARALLPPMLLLLLQPPPLLARALPPVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLE
HYLDKHDPCRCSSTAHRPPQPRVCTFSPQRVSPTTSPRPASPVPGSERRGSRPEMTPVSLRSTKEGPETPPSSSSSSLSVLGGKCGQPGD
SGRTANGLPGPRSQALSSSSDEGSPCPGMGGPLDAPGSPLACTEPSRTWARGRMDTQPDRKPSRIPTPRGPRRPSGPAELGTWHALHSVT

--------------------------------------------------------------
>54394_54394_5_MMP11-GAS2L1_MMP11_chr22_24115165_ENST00000215743_GAS2L1_chr22_29706429_ENST00000407647_length(transcript)=1860nt_BP=160nt
ATAAGGGGCGGCGGCCCGGAGCGGCCCAGCAAGCCCAGCAGCCCCGGGGCGGATGGCTCCGGCCGCCTGGCTCCGCAGCGCGGCCGCGCG
CGCCCTCCTGCCCCCGATGCTGCTGCTGCTGCTCCAGCCGCCGCCGCTGCTGGCCCGGGCTCTGCCGCCGGTGAGGGAGATTCTGGGCCG
CTGCACCTGCCCTGACCAGTTTCCCATGATCAAGGTCTCAGAGGGGAAGTACCGTGTGGGGGACTCGAGCCTGCTCATCTTTGTGCGGGT
GCTGAGGAGCCACGTGATGGTGCGAGTGGGTGGTGGCTGGGACACGCTGGAGCATTACCTGGACAAGCACGACCCGTGCCGCTGCTCCTC
CACTGCTCATCGCCCACCCCAGCCGAGGGTCTGCACCTTTTCTCCACAGAGGGTGTCGCCCACCACCAGTCCCCGCCCTGCTAGCCCAGT
CCCTGGGAGTGAGCGCCGGGGCTCCCGGCCTGAGATGACTCCCGTTAGCTTACGAAGCACAAAGGAGGGGCCCGAGACCCCACCCAGGCC
CCGGGATCAGCTGCCCCCCCATCCCCGCTCCCGCCGCTACTCCGGGGACAGTGACTCCTCAGCCTCCTCCGCCCAGAGCGGCCCCCTTGG
TACCCGCAGTGATGACACAGGCACTGGCCCCCGGAGGGAGCGACCCAGCCGGCGGCTGACCACAGGCACCCCGGCCTCTCCGAGACGGCC
TCCTGCCTGCGCAGCCAGTCCCGAGACCGGCTGGATCGCGGCCGGCCCCGGGGGGCCCCAGGAGGCAGGGGAGCCCAGCTGTCGGTCCCC
AGCCCTGCCCGGCGGGCCCGGAGCCAGAGCCGCGAGGAGCAGGCTGTGCTGCTTGTGCGCAGGGATCGAGACGGGCAGCACTCATGGGTG
CCAAGGGGCAGGGGCAGTGGGGGCTCGGGCAGGAGCACCCCCCAGACTCCCCGTGCCCGCAGCCCTGCAGCACCCCGGCTTTCCCGGGTC
TCCAGCCCCAGTCCAGAGTTGGGCACCACACCGGCCAGCATCTTCCGCACACCCCTGCAGCTCGACCCGCAGCAGGAGCAGCAGCTGTTC
CGGCGCCTGGAAGAGGAGTTCCTGGCCAATGCCCGGGCCCTTGAGGCTGTTGCTAGCGTGACCCCCACTGGACCAGCCCCTGACCCAGCT
CGGGCCCCCGACCCTCCAGCTCCTGACTCTGCCTATTGTTCCTCCAGTTCCTCCTCTTCGTCCCTCAGCGTCCTGGGTGGCAAATGTGGC
CAACCTGGGGACTCTGGCCGGACGGCCAATGGGCTGCCTGGGCCCCGAAGCCAAGCCCTTTCCAGCTCCTCCGATGAAGGCAGCCCCTGC
CCTGGCATGGGGGGGCCACTAGATGCACCTGGGAGCCCCCTGGCTTGCACTGAACCCTCGAGGACCTGGGCACGGGGTCGGATGGACACA
CAGCCAGACCGTAAACCCTCACGTATCCCCACGCCTCGGGGCCCCCGCCGCCCCTCCGGACCCGCAGAGCTGGGGACATGGCATGCCCTG
CACTCAGTCACCCCGAGGGCTGAGCCAGATTCCTGGATGTGATGGACCAGCTCAGCTGTCCCCAGACCCCATCCCTTCTCCTTTTCCTTT
GTGGCCTTAACCCTTCTGCATCAGGGAGCCCCCTCTGCCTCTTGAGTACCAGACCTCATGGGACCAGACCCCTTGGGACCACATGGCACA
ATGGGACCTCTGTTGTACATTCCGGTTGGGGGATGAGCGTTGCTATTTAATTACTAATATTATTGAATGCCTTAGAGGAGGCCGGGCGAG

>54394_54394_5_MMP11-GAS2L1_MMP11_chr22_24115165_ENST00000215743_GAS2L1_chr22_29706429_ENST00000407647_length(amino acids)=362AA_BP=34
MAPAAWLRSAAARALLPPMLLLLLQPPPLLARALPPVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLE
HYLDKHDPCRCSSTAHRPPQPRVCTFSPQRVSPTTSPRPASPVPGSERRGSRPEMTPVSLRSTKEGPETPPRPRDQLPPHPRSRRYSGDS
DSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPACAASPETGWIAAGPGGPQEAGEPSCRSPALPGGPGARAARSRLCC
LCAGIETGSTHGCQGAGAVGARAGAPPRLPVPAALQHPGFPGSPAPVQSWAPHRPASSAHPCSSTRSRSSSCSGAWKRSSWPMPGPLRLL

--------------------------------------------------------------
>54394_54394_6_MMP11-GAS2L1_MMP11_chr22_24115165_ENST00000215743_GAS2L1_chr22_29706429_ENST00000407854_length(transcript)=1860nt_BP=160nt
ATAAGGGGCGGCGGCCCGGAGCGGCCCAGCAAGCCCAGCAGCCCCGGGGCGGATGGCTCCGGCCGCCTGGCTCCGCAGCGCGGCCGCGCG
CGCCCTCCTGCCCCCGATGCTGCTGCTGCTGCTCCAGCCGCCGCCGCTGCTGGCCCGGGCTCTGCCGCCGGTGAGGGAGATTCTGGGCCG
CTGCACCTGCCCTGACCAGTTTCCCATGATCAAGGTCTCAGAGGGGAAGTACCGTGTGGGGGACTCGAGCCTGCTCATCTTTGTGCGGGT
GCTGAGGAGCCACGTGATGGTGCGAGTGGGTGGTGGCTGGGACACGCTGGAGCATTACCTGGACAAGCACGACCCGTGCCGCTGCTCCTC
CACTGCTCATCGCCCACCCCAGCCGAGGGTCTGCACCTTTTCTCCACAGAGGGTGTCGCCCACCACCAGTCCCCGCCCTGCTAGCCCAGT
CCCTGGGAGTGAGCGCCGGGGCTCCCGGCCTGAGATGACTCCCGTTAGCTTACGAAGCACAAAGGAGGGGCCCGAGACCCCACCCAGGCC
CCGGGATCAGCTGCCCCCCCATCCCCGCTCCCGCCGCTACTCCGGGGACAGTGACTCCTCAGCCTCCTCCGCCCAGAGCGGCCCCCTTGG
TACCCGCAGTGATGACACAGGCACTGGCCCCCGGAGGGAGCGACCCAGCCGGCGGCTGACCACAGGCACCCCGGCCTCTCCGAGACGGCC
TCCTGCCTGCGCAGCCAGTCCCGAGACCGGCTGGATCGCGGCCGGCCCCGGGGGGCCCCAGGAGGCAGGGGAGCCCAGCTGTCGGTCCCC
AGCCCTGCCCGGCGGGCCCGGAGCCAGAGCCGCGAGGAGCAGGCTGTGCTGCTTGTGCGCAGGGATCGAGACGGGCAGCACTCATGGGTG
CCAAGGGGCAGGGGCAGTGGGGGCTCGGGCAGGAGCACCCCCCAGACTCCCCGTGCCCGCAGCCCTGCAGCACCCCGGCTTTCCCGGGTC
TCCAGCCCCAGTCCAGAGTTGGGCACCACACCGGCCAGCATCTTCCGCACACCCCTGCAGCTCGACCCGCAGCAGGAGCAGCAGCTGTTC
CGGCGCCTGGAAGAGGAGTTCCTGGCCAATGCCCGGGCCCTTGAGGCTGTTGCTAGCGTGACCCCCACTGGACCAGCCCCTGACCCAGCT
CGGGCCCCCGACCCTCCAGCTCCTGACTCTGCCTATTGTTCCTCCAGTTCCTCCTCTTCGTCCCTCAGCGTCCTGGGTGGCAAATGTGGC
CAACCTGGGGACTCTGGCCGGACGGCCAATGGGCTGCCTGGGCCCCGAAGCCAAGCCCTTTCCAGCTCCTCCGATGAAGGCAGCCCCTGC
CCTGGCATGGGGGGGCCACTAGATGCACCTGGGAGCCCCCTGGCTTGCACTGAACCCTCGAGGACCTGGGCACGGGGTCGGATGGACACA
CAGCCAGACCGTAAACCCTCACGTATCCCCACGCCTCGGGGCCCCCGCCGCCCCTCCGGACCCGCAGAGCTGGGGACATGGCATGCCCTG
CACTCAGTCACCCCGAGGGCTGAGCCAGATTCCTGGATGTGATGGACCAGCTCAGCTGTCCCCAGACCCCATCCCTTCTCCTTTTCCTTT
GTGGCCTTAACCCTTCTGCATCAGGGAGCCCCCTCTGCCTCTTGAGTACCAGACCTCATGGGACCAGACCCCTTGGGACCACATGGCACA
ATGGGACCTCTGTTGTACATTCCGGTTGGGGGATGAGCGTTGCTATTTAATTACTAATATTATTGAATGCCTTAGAGGAGGCCGGGCGAG

>54394_54394_6_MMP11-GAS2L1_MMP11_chr22_24115165_ENST00000215743_GAS2L1_chr22_29706429_ENST00000407854_length(amino acids)=362AA_BP=34
MAPAAWLRSAAARALLPPMLLLLLQPPPLLARALPPVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLE
HYLDKHDPCRCSSTAHRPPQPRVCTFSPQRVSPTTSPRPASPVPGSERRGSRPEMTPVSLRSTKEGPETPPRPRDQLPPHPRSRRYSGDS
DSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPACAASPETGWIAAGPGGPQEAGEPSCRSPALPGGPGARAARSRLCC
LCAGIETGSTHGCQGAGAVGARAGAPPRLPVPAALQHPGFPGSPAPVQSWAPHRPASSAHPCSSTRSRSSSCSGAWKRSSWPMPGPLRLL

--------------------------------------------------------------
>54394_54394_7_MMP11-GAS2L1_MMP11_chr22_24115165_ENST00000215743_GAS2L1_chr22_29706429_ENST00000471961_length(transcript)=1860nt_BP=160nt
ATAAGGGGCGGCGGCCCGGAGCGGCCCAGCAAGCCCAGCAGCCCCGGGGCGGATGGCTCCGGCCGCCTGGCTCCGCAGCGCGGCCGCGCG
CGCCCTCCTGCCCCCGATGCTGCTGCTGCTGCTCCAGCCGCCGCCGCTGCTGGCCCGGGCTCTGCCGCCGGTGAGGGAGATTCTGGGCCG
CTGCACCTGCCCTGACCAGTTTCCCATGATCAAGGTCTCAGAGGGGAAGTACCGTGTGGGGGACTCGAGCCTGCTCATCTTTGTGCGGGT
GCTGAGGAGCCACGTGATGGTGCGAGTGGGTGGTGGCTGGGACACGCTGGAGCATTACCTGGACAAGCACGACCCGTGCCGCTGCTCCTC
CACTGCTCATCGCCCACCCCAGCCGAGGGTCTGCACCTTTTCTCCACAGAGGGTGTCGCCCACCACCAGTCCCCGCCCTGCTAGCCCAGT
CCCTGGGAGTGAGCGCCGGGGCTCCCGGCCTGAGATGACTCCCGTTAGCTTACGAAGCACAAAGGAGGGGCCCGAGACCCCACCCAGGCC
CCGGGATCAGCTGCCCCCCCATCCCCGCTCCCGCCGCTACTCCGGGGACAGTGACTCCTCAGCCTCCTCCGCCCAGAGCGGCCCCCTTGG
TACCCGCAGTGATGACACAGGCACTGGCCCCCGGAGGGAGCGACCCAGCCGGCGGCTGACCACAGGCACCCCGGCCTCTCCGAGACGGCC
TCCTGCCTGCGCAGCCAGTCCCGAGACCGGCTGGATCGCGGCCGGCCCCGGGGGGCCCCAGGAGGCAGGGGAGCCCAGCTGTCGGTCCCC
AGCCCTGCCCGGCGGGCCCGGAGCCAGAGCCGCGAGGAGCAGGCTGTGCTGCTTGTGCGCAGGGATCGAGACGGGCAGCACTCATGGGTG
CCAAGGGGCAGGGGCAGTGGGGGCTCGGGCAGGAGCACCCCCCAGACTCCCCGTGCCCGCAGCCCTGCAGCACCCCGGCTTTCCCGGGTC
TCCAGCCCCAGTCCAGAGTTGGGCACCACACCGGCCAGCATCTTCCGCACACCCCTGCAGCTCGACCCGCAGCAGGAGCAGCAGCTGTTC
CGGCGCCTGGAAGAGGAGTTCCTGGCCAATGCCCGGGCCCTTGAGGCTGTTGCTAGCGTGACCCCCACTGGACCAGCCCCTGACCCAGCT
CGGGCCCCCGACCCTCCAGCTCCTGACTCTGCCTATTGTTCCTCCAGTTCCTCCTCTTCGTCCCTCAGCGTCCTGGGTGGCAAATGTGGC
CAACCTGGGGACTCTGGCCGGACGGCCAATGGGCTGCCTGGGCCCCGAAGCCAAGCCCTTTCCAGCTCCTCCGATGAAGGCAGCCCCTGC
CCTGGCATGGGGGGGCCACTAGATGCACCTGGGAGCCCCCTGGCTTGCACTGAACCCTCGAGGACCTGGGCACGGGGTCGGATGGACACA
CAGCCAGACCGTAAACCCTCACGTATCCCCACGCCTCGGGGCCCCCGCCGCCCCTCCGGACCCGCAGAGCTGGGGACATGGCATGCCCTG
CACTCAGTCACCCCGAGGGCTGAGCCAGATTCCTGGATGTGATGGACCAGCTCAGCTGTCCCCAGACCCCATCCCTTCTCCTTTTCCTTT
GTGGCCTTAACCCTTCTGCATCAGGGAGCCCCCTCTGCCTCTTGAGTACCAGACCTCATGGGACCAGACCCCTTGGGACCACATGGCACA
ATGGGACCTCTGTTGTACATTCCGGTTGGGGGATGAGCGTTGCTATTTAATTACTAATATTATTGAATGCCTTAGAGGAGGCCGGGCGAG

>54394_54394_7_MMP11-GAS2L1_MMP11_chr22_24115165_ENST00000215743_GAS2L1_chr22_29706429_ENST00000471961_length(amino acids)=362AA_BP=34
MAPAAWLRSAAARALLPPMLLLLLQPPPLLARALPPVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLE
HYLDKHDPCRCSSTAHRPPQPRVCTFSPQRVSPTTSPRPASPVPGSERRGSRPEMTPVSLRSTKEGPETPPRPRDQLPPHPRSRRYSGDS
DSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPACAASPETGWIAAGPGGPQEAGEPSCRSPALPGGPGARAARSRLCC
LCAGIETGSTHGCQGAGAVGARAGAPPRLPVPAALQHPGFPGSPAPVQSWAPHRPASSAHPCSSTRSRSSSCSGAWKRSSWPMPGPLRLL

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Fusion Gene PPI Analysis for MMP11-GAS2L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MMP11-GAS2L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MMP11-GAS2L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource