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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MMP16-ZFHX4 (FusionGDB2 ID:54411)

Fusion Gene Summary for MMP16-ZFHX4

check button Fusion gene summary
Fusion gene informationFusion gene name: MMP16-ZFHX4
Fusion gene ID: 54411
HgeneTgene
Gene symbol

MMP16

ZFHX4

Gene ID

4325

79776

Gene namematrix metallopeptidase 16zinc finger homeobox 4
SynonymsC8orf57|MMP-X2|MT-MMP2|MT-MMP3|MT3-MMPZFH4|ZHF4
Cytomap

8q21.3

8q21.13

Type of geneprotein-codingprotein-coding
Descriptionmatrix metalloproteinase-16MMP-16MT-MMP 3MT3MMPMTMMP3Putative transmembrane protein C8orf57matrix metallopeptidase 16 (membrane-inserted)membrane-type matrix metalloproteinase 3membrane-type-3 matrix metalloproteinasezinc finger homeobox protein 4zinc-finger homeodomain protein 4
Modification date2020031320200313
UniProtAcc

P51512

.
Ensembl transtripts involved in fusion geneENST00000286614, ENST00000544227, 
ENST00000050961, ENST00000455469, 
ENST00000517683, ENST00000518282, 
ENST00000521891, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 3=75
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MMP16 [Title/Abstract] AND ZFHX4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMMP16(89086833)-ZFHX4(77745574), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMMP16

GO:0006508

proteolysis

24970228

HgeneMMP16

GO:0016485

protein processing

27229514


check buttonFusion gene breakpoints across MMP16 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZFHX4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-FC-A4JI-01AMMP16chr8

89086833

-ZFHX4chr8

77745574

+


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Fusion Gene ORF analysis for MMP16-ZFHX4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000286614ENST00000050961MMP16chr8

89086833

-ZFHX4chr8

77745574

+
5CDS-intronENST00000286614ENST00000455469MMP16chr8

89086833

-ZFHX4chr8

77745574

+
5CDS-intronENST00000286614ENST00000517683MMP16chr8

89086833

-ZFHX4chr8

77745574

+
5CDS-intronENST00000286614ENST00000518282MMP16chr8

89086833

-ZFHX4chr8

77745574

+
5UTR-3CDSENST00000544227ENST00000521891MMP16chr8

89086833

-ZFHX4chr8

77745574

+
5UTR-intronENST00000544227ENST00000050961MMP16chr8

89086833

-ZFHX4chr8

77745574

+
5UTR-intronENST00000544227ENST00000455469MMP16chr8

89086833

-ZFHX4chr8

77745574

+
5UTR-intronENST00000544227ENST00000517683MMP16chr8

89086833

-ZFHX4chr8

77745574

+
5UTR-intronENST00000544227ENST00000518282MMP16chr8

89086833

-ZFHX4chr8

77745574

+
In-frameENST00000286614ENST00000521891MMP16chr8

89086833

-ZFHX4chr8

77745574

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000286614MMP16chr889086833-ENST00000521891ZFHX4chr877745574+11750150419890292943

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000286614ENST00000521891MMP16chr889086833-ZFHX4chr877745574+0.0004373080.9995627

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Fusion Genomic Features for MMP16-ZFHX4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MMP16-ZFHX4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:89086833/chr8:77745574)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MMP16

P51512

.
FUNCTION: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. {ECO:0000269|PubMed:11278606}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMMP16chr8:89086833chr8:77745574ENST00000286614-71099_106407608.0MotifCysteine switch
HgeneMMP16chr8:89086833chr8:77745574ENST00000286614-710340_388407608.0RepeatNote=Hemopexin 1
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693113265_329410823572.0Coiled coilOntology_term=ECO:0000255
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693111644_179310823572.0Compositional biasNote=Gln-rich
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693111949_204810823572.0Compositional biasNote=Pro-rich
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693112345_242910823572.0Compositional biasNote=Pro-rich
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693113050_312410823572.0Compositional biasNote=Pro-rich
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693113454_353310823572.0Compositional biasNote=Ser-rich
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693112084_214310823572.0DNA bindingHomeobox 1
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693112181_224010823572.0DNA bindingHomeobox 2
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693112560_261910823572.0DNA bindingHomeobox 3
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693112884_294310823572.0DNA bindingHomeobox 4
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693111172_119510823572.0Zinc fingerC2H2-type 8
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693111201_122410823572.0Zinc fingerC2H2-type 9
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693111352_137410823572.0Zinc fingerC2H2-type 10
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693111380_140310823572.0Zinc fingerC2H2-type 11
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693111496_152210823572.0Zinc fingerC2H2-type 12
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693111548_157210823572.0Zinc fingerC2H2-type 13
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693111901_192410823572.0Zinc fingerC2H2-type 14
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693112267_229110823572.0Zinc fingerC2H2-type 15%3B degenerate
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693112448_247010823572.0Zinc fingerC2H2-type 16
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693112630_265310823572.0Zinc fingerC2H2-type 17
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693112962_298610823572.0Zinc fingerC2H2-type 18
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693113354_337810823572.0Zinc fingerC2H2-type 19%3B degenerate
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693113398_342210823572.0Zinc fingerC2H2-type 20

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMMP16chr8:89086833chr8:77745574ENST00000286614-710389_434407608.0RepeatNote=Hemopexin 2
HgeneMMP16chr8:89086833chr8:77745574ENST00000286614-710436_484407608.0RepeatNote=Hemopexin 3
HgeneMMP16chr8:89086833chr8:77745574ENST00000286614-710485_532407608.0RepeatNote=Hemopexin 4
HgeneMMP16chr8:89086833chr8:77745574ENST00000286614-710120_564407608.0Topological domainExtracellular
HgeneMMP16chr8:89086833chr8:77745574ENST00000286614-710586_607407608.0Topological domainCytoplasmic
HgeneMMP16chr8:89086833chr8:77745574ENST00000286614-710565_585407608.0TransmembraneHelical
TgeneZFHX4chr8:89086833chr8:77745574ENST00000455469311523_52610823572.0Compositional biasNote=Poly-Ser
TgeneZFHX4chr8:89086833chr8:77745574ENST000004554693111021_104510823572.0Zinc fingerC2H2-type 7
TgeneZFHX4chr8:89086833chr8:77745574ENST00000455469311613_63610823572.0Zinc fingerC2H2-type 1
TgeneZFHX4chr8:89086833chr8:77745574ENST00000455469311644_66710823572.0Zinc fingerC2H2-type 2
TgeneZFHX4chr8:89086833chr8:77745574ENST00000455469311699_72310823572.0Zinc fingerC2H2-type 3
TgeneZFHX4chr8:89086833chr8:77745574ENST00000455469311767_78910823572.0Zinc fingerC2H2-type 4%3B degenerate
TgeneZFHX4chr8:89086833chr8:77745574ENST00000455469311917_94110823572.0Zinc fingerC2H2-type 5
TgeneZFHX4chr8:89086833chr8:77745574ENST00000455469311973_99510823572.0Zinc fingerC2H2-type 6


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Fusion Gene Sequence for MMP16-ZFHX4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54411_54411_1_MMP16-ZFHX4_MMP16_chr8_89086833_ENST00000286614_ZFHX4_chr8_77745574_ENST00000521891_length(transcript)=11750nt_BP=1504nt
TCTTTGAGCCGGAACCGCCGGTGAACTTAGGCGCCACGTTCCCGGTGACTGACCCCGGAGGATGGTGAACAGGAACTACTGCTGACCCTG
TCTTCGCCGCTGCCTCTCGGGGGCTGCCGAGCGCGGGGCCCCTGTCTCCTCCCCTTGCCCGGCTGTGGGTGAACCTGCAGGCTCCTTACC
CACCCGGAGGACTTTTTTTTGAAAGGAAACGAGGGAGGGAGGGAGAGGGAGAGAGGGAGAAAACGAAGGGGAGCTCGTCCATCCATTGAA
GCACAGTTCACTATGATCTTACTCACATTCAGCACTGGAAGACGGTTGGATTTCGTGCATCATTCGGGGGTGTTTTTCTTGCAAACCTTG
CTTTGGATTTTATGTGCTACAGTCTGCGGAACGGAGCAGTATTTCAATGTGGAGGTTTGGTTACAAAAGTACGGCTACCTTCCACCGACT
GACCCCAGAATGTCAGTGCTGCGCTCTGCAGAGACCATGCAGTCTGCCCTAGCTGCCATGCAGCAGTTCTATGGCATTAACATGACAGGA
AAAGTGGACAGAAACACAATTGACTGGATGAAGAAGCCCCGATGCGGTGTACCTGACCAGACAAGAGGTAGCTCCAAATTTCATATTCGT
CGAAAGCGATATGCATTGACAGGACAGAAATGGCAGCACAAGCACATCACTTACAGTATAAAGAACGTAACTCCAAAAGTAGGAGACCCT
GAGACTCGTAAAGCTATTCGCCGTGCCTTTGATGTGTGGCAGAATGTAACTCCTCTGACATTTGAAGAAGTTCCCTACAGTGAATTAGAA
AATGGCAAACGTGATGTGGATATAACCATTATTTTTGCATCTGGTTTCCATGGGGACAGCTCTCCCTTTGATGGAGAGGGAGGATTTTTG
GCACATGCCTACTTCCCTGGACCAGGAATTGGAGGAGATACCCATTTTGACTCAGATGAGCCATGGACACTAGGAAATCCTAATCATGAT
GGAAATGACTTATTTCTTGTAGCAGTCCATGAACTGGGACATGCTCTGGGATTGGAGCATTCCAATGACCCCACTGCCATCATGGCTCCA
TTTTACCAGTACATGGAAACAGACAACTTCAAACTACCTAATGATGATTTACAGGGCATCCAGAAGATATATGGTCCACCTGACAAGATT
CCTCCACCTACAAGACCTCTACCGACAGTGCCCCCACACCGCTCTATTCCTCCGGCTGACCCAAGGAAAAATGACAGGCCAAAACCTCCT
CGGCCTCCAACCGGCAGACCCTCCTATCCCGGAGCCAAACCCAACATCTGTGATGGGAACTTTAACACTCTAGCTATTCTTCGTCGTGAG
ATGTTTGTTTTCAAGGACCAGTGGTTTTGGCGAGTGAGAAACAACAGGGTGATGGATGGATACCCAATGCAAATTACTTACTTCTGGCGG
GGCTTGCCTCCTAGTATCGATGCAGTTTATGAAAATAGCGACGGGAATTTTGTGTTCTTTAAAGAAACTGCCTCATTGGGAGCCAGGACT
TGTGATGATGATCTTACAGAGCAGCAGTTGAGATCGACCTCAGAAGAACAAAGTGAGGAGGCAGAAGGAGCTATTAAGCCTACAGCAGTG
GCCGAGGACGATGAAAAAGACACAAGTGAGAGAGACAATAGTGAAGGCAAAAACTCTAATAAAGACTCTGGGATAATCACACCAGAGAAG
GAACTAAAAGTTAGTGTGGCAGGGGGTACCCAGCCACTCCTGCTGGCAAAAGAAGAGGATGTTGCAACAAAAAGGTCAAAACCTACAGAG
GACAATAAATTCTGTCATGAACAGTTCTATCAATGTCCTTATTGTAACTACAATAGTAGGGACCAAAGTCGTATCCAGATGCACGTCCTA
TCACAGCACTCGGTGCAGCCGGTCATCTGCTGTCCTCTCTGTCAGGACGTCCTCAGCAACAAAATGCATCTCCAACTGCATCTGACGCAT
TTGCACAGTGTGTCTCCAGACTGTGTGGAGAAGCTGCTTATGACAGTGCCTGTCCCTGATGTGATGATGCCAAACAGTATGCTACTGCCA
GCAGCTGCCTCTGAGAAATCAGAGCGGGACACACCTGCAGCCGTGACAGCTGAGGGGTCTGGGAAATATTCAGGTGAAAGTCCAATGGAT
GACAAAAGCATGGCAGGTCTCGAGGATTCAAAGGCTAATGTGGAAGTAAAGAATGAGGAGCAGAAACCGACTAAAGAACCCTTGGAAGTC
TCAGAATGGAATAAAAATAGCAGTAAGGATGTGAAAATCCCCGACACACTGCAAGATCAATTAAATGAACAGCAAAAAAGGCAACCGCTC
TCTGTTTCTGACCGTCATGTCTACAAGTATCGCTGTAACCATTGTAGCTTGGCTTTCAAAACTATGCAGAAGCTTCAGATACATTCCCAG
TATCATGCAATTCGGGCTGCGACAATGTGTAACCTCTGCCAGCGCAGTTTCCGTACATTCCAGGCTTTAAAAAAACACTTGGAAGCAGGC
CACCCTGAACTGAGTGAAGCTGAACTTCAACAGCTATATGCCTCCTTGCCCGTGAATGGAGAACTGTGGGCAGAGAGCGAAACTATGTCC
CAGGATGACCATGGCCTAGAGCAGGAAATGGAGAGAGAGTATGAGGTGGACCACGAAGGGAAAGCAAGTCCTGTAGGAAGTGATAGTAGC
TCTATTCCAGATGACATGGGCTCTGAACCAAAGCGGACCTTACCTTTTAGAAAAGGGCCCAATTTTACGATGGAAAAATTCCTTGATCCA
TCTCGTCCATATAAATGTACAGTGTGTAAAGAGTCATTCACCCAAAAGAACATTCTCTTGGTCCACTATAATTCAGTTTCTCACTTGCAT
AAGCTGAAAAAAGTTTTGCAGGAAGCCTCCAGTCCTGTCCCACAAGAAACCAACAGCAACACAGATAACAAACCCTACAAGTGCAGCATC
TGCAATGTTGCATACAGCCAAAGCTCAACATTGGAAATCCACATGAGGTCTGTGCTCCACCAGACAAAGGCTAGGGCTGCAAAGCTGGAG
CCCAGTGGTCATGTGGCTGGTGGGCACAGCATTGCAGCAAATGTCAACAGCCCTGGCCAGGGGATGTTAGATTCCATGAGTTTAGCAGCT
GTAAACAGCAAAGATACCCATTTAGATGCCAAAGAATTAAATAAAAAGCAAACTCCTGATTTAATCTCTGCTCAACCTGCACATCACCCA
CCACAGTCACCAGCACAAATTCAGATGCAACTACAGCACGAATTACAACAGCAAGCCGCATTCTTTCAGCCTCAGTTTCTAAACCCAGCC
TTTTTGCCTCATTTTCCTATGACCCCAGAAGCACTGCTGCAGTTTCAGCAGCCTCAGTTTCTCTTTCCATTTTATATACCTGGGACGGAG
TTCAGCTTGGGGCCAGATTTGGGCTTGCCAGGCTCTGCCACATTTGGGATGCCTGGCATGACAGGAATGGCTGGCTCCTTGCTTGAAGAC
CTAAAGCAGCAGATTCAAACCCAACATCACGTTGGTCAAACTCAACTCCAGATACTACAGCAACAAGCACAACAATACCAAGCCACACAG
CCCCAGCTGCAGCCTCAAAAACAACAGCAGCAGCCACCACCTCCACAGCAGCAGCAGCAACAGCAGGCAAGCAAATTATTGAAACAAGAG
CAAAGTAACATAGTGAGTGCAGACTGCCAAATCATGAAGGATGTGCCATCTTATAAGGAGGCAGAAGATATTTCTGAAAAGCCAGAAAAA
CCAAAGCAGGAATTTATAAGTGAAGGTGAAGGACTCAAAGAAGGCAAAGACACAAAGAAGCAAAAATCCTTGGAACCATCCATCCCACCA
CCCCGAATAGCTTCAGGGGCCAGAGGAAATGCTGCCAAAGCGTTATTGGAAAACTTTGGTTTTGAACTGGTCATTCAGTATAACGAAAAC
AGGCAGAAGGTACAGAAGAAGGGCAAAAGTGGTGAAGGCGAAAACACTGACAAACTAGAATGTGGAACATGTGGTAAATTGTTTTCCAAT
GTTCTTATTTTAAAGAGTCACCAAGAACATGTACATGGGCAATTTTTTCCATATGCAGCGCTAGAAAAATTTGCTCGTCAATACAGGGAG
GCCTATGACAAGCTTTATCCAATTTCTCCATCTTCTCCAGAAACGCCGCCCCCGCCACCTCCTCCTCCTCCCTTGCCTCCGGCTCCTCCA
CAGCCTTCTTCTATGGGTCCTGTAAAGATCCCCAACACGGTTTCTACTCCTCTGCAAGCTCCACCACCCACTCCTCCCCCACCACCACCA
CCTCCTCCTCCTCCTCCTCCTCCCCCCCCACCTCCTCCACCTTCTGCTCCTCCACAGGTCCAACTGCCGGTTTCTCTGGACCTGCCGCTC
TTTCCTTCCATTATGATGCAACCTGTGCAACACCCTGCGCTTCCTCCCCAGCTTGCCCTGCAGCTGCCACAGATGGACGCACTCTCTGCA
GACCTCACCCAACTTTGCCAGCAGCAGCTCGGATTAGATCCCAACTTCTTAAGACATTCTCAGTTCAAACGCCCACGGACAAGAATTACA
GATGATCAGCTAAAAATCCTGAGGGCTTATTTTGACATTAATAATTCTCCAAGTGAAGAACAGATCCAGGAAATGGCAGAGAAATCTGGC
CTCTCCCAAAAAGTTATCAAACACTGGTTTAGAAATACGCTTTTTAAGGAACGACAGAGAAATAAAGATTCACCATACAACTTCAGTAAC
CCTCCTATAACGGTTTTAGAAGATATCAGAATTGATCCACAGCCCACCTCTTTAGAACATTACAAATCTGATGCATCATTCAGTAAAAGG
TCTTCTAGAACGAGATTTACTGACTACCAGCTTAGGGTTCTGCAAGACTTTTTTGACACAAACGCTTACCCAAAAGATGATGAAATAGAA
CAACTCTCCACTGTTCTCAATCTGCCTACCCGGGTTATTGTTGTATGGTTCCAGAATGCTCGTCAGAAAGCACGAAAGAGTTATGAGAAT
CAAGCAGAAACAAAAGATAATGAAAAAAGAGAACTCACTAATGAACGGTACATTCGAACAAGCAACATGCAGTACCAGTGTAAAAAGTGC
AATGTGGTTTTCCCCAGGATCTTTGACTTGATTACGCATCAGAAAAAGCAGTGTTACAAGGATGAAGATGATGATGCCCAAGATGAAAGC
CAAACAGAAGACTCCATGGATGCCACTGATCAAGTGGTATACAAGCATTGCACAGTGTCTGGCCAAACGGATGCAGCTAAAAACGCTGCT
GCCCCTGCAGCAAGTTCTGGCTCTGGGACCAGCACCCCCCTGATTCCATCACCCAAACCAGAACCTGAGAAGACTTCTCCAAAACCTGAA
TATCCCGCAGAAAAGCCAAAGCAGAGTGACCCCTCTCCCCCTTCTCAAGGCACCAAACCAGCCCTGCCATTAGCATCGACTTCCTCGGAC
CCACCACAGGCATCCACAGCCCAGCCACAGCCACAGCCACAGCCACCAAAACAACCCCAACTTATCGGAAGACCTCCCTCGGCCTCTCAA
ACACCGGTCCCTTCCAGTCCACTGCAAATTTCCATGACGTCTCTCCAGAACAGTCTACCTCCACAGTTACTACAATACCAATGTGATCAG
TGTACAGTTGCCTTCCCAACTCTGGAACTCTGGCAGGAACACCAGCACATGCACTTCCTTGCTGCTCAAAACCAATTCCTTCACTCTCCG
TTCTTGGAAAGGCCCATGGACATGCCCTACATGATATTTGACCCCAACAATCCGCTGATGACTGGACAACTGCTGGGCAGTTCCCTCACT
CAAATGCCCCCTCAGGCCAGTTCCTCCCACACCACAGCCCCCACAACGGTTGCTGCTTCCCTAAAAAGGAAACTAGACGATAAAGAAGAT
AATAATTGCAGTGAAAAAGAAGGAGGGAATAGCGGTGAAGACCAACACCGAGATAAACGCTTGAGAACCACGATCACCCCGGAACAGCTG
GAAATACTCTATGAAAAATACTTGCTGGATTCCAATCCTACCAGAAAAATGCTTGATCATATTGCCCGCGAAGTCGGGCTGAAAAAAAGG
GTCGTGCAAGTCTGGTTCCAGAATACACGAGCGCGGGAGAGGAAAGGCCAGTTCCGGGCGGTGGGTCCAGCACAGTCTCATAAACGGTGT
CCGTTTTGCCGAGCCCTGTTTAAAGCAAAGTCGGCCTTAGAAAGCCACATTCGCTCTCGGCACTGGAATGAAGGAAAGCAGGCAGGTTAC
AGCTTGCCACCAAGCCCTTTAATATCCACCGAAGATGGGGGAGAAAGCCCACAGAAATACATCTATTTTGATTACCCATCTTTGCCATTA
ACTAAAATTGATCTATCAAGTGAGAATGAATTGGCTTCTACAGTGTCAACACCTGTTAGTAAAACAGCAGAGCTGTCACCGAAGAATCTT
TTAAGCCCTTCTTCTTTTAAAGCAGAGTGTTCTGAGGATGTAGAGAATTTAAATGCCCCTCCTGCTGAGGCTGGGTATGATCAAAATAAA
ACCGATTTTGATGAGACTTCATCGATTAATACGGCAATCAGTGACGCCACCACCGGAGACGAGGGAAACACTGAAATGGAAAGCACCACA
GGAAGTTCCGGAGATGTGAAACCGGCTTTGTCTCCCAAAGAGCCAAAAACTCTGGATACTCTGCCAAAACCTGCAACCACACCTACCACG
GAGGTCTGCGATGACAAATTTCTCTTTTCTCTCACAAGCCCATCCATCCATTTCAATGACAAAGATGGCGACCACGACCAAAGCTTTTAC
ATCACAGATGACCCGGATGACAACGCCGACCGCAGCGAAACGTCCAGCATAGCGGACCCGAGCTCCCCAAATCCATTCGGATCCAGCAAT
CCCTTTAAATCCAAAAGTAATGATCGGCCGGGTCACAAGCGTTTTCGAACGCAAATGAGCAATCTTCAACTCAAGGTTCTCAAGGCTTGC
TTTAGTGACTACCGAACTCCAACCATGCAAGAATGTGAAATGTTAGGGAATGAGATTGGTCTGCCCAAACGCGTAGTCCAGGTGTGGTTC
CAAAATGCAAGGGCAAAGGAAAAGAAATTTAAAATTAACATAGGGAAGCCTTTCATGATCAATCAAGGCGGAACGGAAGGCACCAAACCA
GAGTGTACCCTCTGCGGGGTGAAGTACTCTGCCCGCTTGTCCATCAGAGATCACATTTTCTCCAAACAGCACATTTCAAAAGTGAGGGAG
ACCGTTGGCAGTCAGCTCGATCGGGAGAAAGATTACTTGGCTCCGACCACGGTTCGGCAGCTGATGGCACAGCAAGAACTTGATCGTATA
AAGAAAGCTTCAGACGTGCTGGGCTTGACGGTACAGCAGCCAGGCATGATGGACAGCAGTTCTCTCCACGGCATCAGCCTGCCAACAGCC
TACCCCGGACTCCCCGGCCTTCCTCCAGTCCTTCTCCCCGGAATGAACGGTCCATCCTCCTTGCCGGGATTTCCACAAAATTCAAACACT
TTAACACCTCCCGGTGCAGGCATGCTTGGGTTTCCTACTTCAGCTACTTCGTCTCCTGCCCTGTCTCTCAGCAGTGCCCCCACCAAACCT
TTGCTGCAGACTCCACCACCTCCACCACCTCCTCCTCCTCCTCCTCCTTCATCCTCTCTGTCAGGACAGCAGACCGAGCAACAGAACAAA
GAATCTGAGAAAAAGCAAACTAAGCCAAACAAGGTGAAAAAAATCAAAGAGGAGGAATTAGAGGCCACCAAACCCGAAAAACACCCCAAA
AAAGAGGAAAAAATCTCATCTGCTCTTTCAGTGTTGGGCAAAGTTGTAGGTGAAACACATGTCGATCCTATTCAGTTGCAGGCATTACAG
AATGCAATTGCTGGTGACCCAGCTTCCTTTATAGGCGGACAGTTCTTGCCATACTTTATCCCTGGGTTTGCTTCTTATTTTACACCTCAG
CTCCCTGGAACAGTGCAGGGGGGATACTTCCCACCTGTCTGTGGCATGGAGAGCCTCTTTCCTTATGGCCCTACAATGCCCCAGACACTG
GCAGGTCTGTCCCCAGGTGCACTGTTGCAGCAGTACCAACAGTATCAGCAGAACCTGCAGGAGTCCCTGCAAAAGCAGCAAAAGCAACAG
CAAGAACAGCAGCAGAAACCAGTTCAGGCAAAGACATCCAAAGTAGAAAGTGACCAGCCGCAAAACTCCAACGATGCTTCAGAAACAAAG
GAAGACAAAAGTACTGCTACAGAAAGCACAAAAGAAGAACCCCAGTTAGAATCCAAAAGTGCAGACTTTTCAGACACTTACGTTGTTCCA
TTCGTCAAGTATGAGTTTATATGCAGAAAGTGCCAGATGATGTTTACTGATGAAGACGCCGCAGTAAATCATCAAAAGTCCTTCTGTTAT
TTCGGTCAGCCTTTGATTGACCCACAAGAGACAGTGCTTCGTGTCCCAGTCAGCAAATATCAGTGTCTTGCCTGTGATGTGGCTATCAGT
GGGAATGAAGCACTTAGCCAACACCTCCAGTCAAGCTTGCACAAAGAGAAAACAATCAAACAAGCAATGAGAAATGCCAAAGAGCATGTT
AGATTATTACCTCACTCAGTCTGCTCCCCTAATCCTAACACCACATCTACCTCGCAGTCTGCAGCTTCTTCTAATAACACCTATCCTCAT
CTTTCTTGCTTCTCCATGAAGTCCTGGCCTAATATCCTTTTCCAAGCGTCTGCCAGGAGAGCTGCTTCTCCCCCTTCTTCTCCTCCTTCC
CTTTCCTTGCCTTCAACGGTTACCTCAAGTTTGTGCAGCACCTCAGGGGTTCAAACCTCACTACCCACAGAAAGTTGTTCAGATGAGTCT
GACAGTGAGCTGAGCCAGAAGCTAGAAGACTTAGATAATTCTTTGGAAGTGAAGGCTAAGCCTGCTTCTGGCCTAGATGGTAATTTCAAT
AGCATCCGAATGGATATGTTCAGTGTGTAGGAGTGAAGACAGGATCCCGTGCTTAAAAAAATAAAAAATAAAAAAATAAAAAAAAAATAA
GACTTTAACTGCAGTTCCAAAGCTTCTCTAACCCAAAAATTACAGTACCAAATGATTGACTCAGGATTGTTTTTCCCATATTGATATGCT
GGCAATATAGGATGGTATGTAATGGACAGAACTGATGCAGATGGTTGAATGCGCTTGTACTATATGCTAAAATATGGAAAAGGAAAAAAA
AATCTCACAAGTTCTTTTGGAACTTGTTTCAAGCCAAAAACTCTCAAGAAAGCAAATTGCACCTCAGCTGGATTGATTTCCAAATGCTAG
CATGTACTGTATGGGAGGATGATCCAGATGTTTCAAAGAGAATTTCTCTTAGTTTAGTTAGGTGTAATTCAGTAGCTTTAAATTCTCAGG
TCAGAACATAACATTTCTCATTTGTTAAAAGCAGCAAGAAGCCTGGTAAAACTGTGACTTTTCCCCAAACGTCAATCTTTATTAGAAAGC
ATTTTCTAGGTGTGTTTAGTGTACAAAGAGACTTTATAACCCTTACTGGACAACACACAGATCCTTGAGCTCACGCTGCAGGATAGTACA
GTTTTACCGCAGAGGGAATCTGGAACAGTGGAATCATGTGTCTGCCCTGTGTATTGCAGTTTGTATTGCCACAAGCTATATTTATACCAG
TGTCACCCTTTTCTTGTAGAATATACTAATAATCTGTGCCAACTCTACCTTCTCACTTTTACCTCTGACGTCATTCTTTTTTTCTGAAAG
AGGTAATAATTCTAGTTTTGATAGACTCTGAGGATTATGTGAACAGGACATTTTTCATTTGTGAATTTAATGCTATACTGTCAAGGTACT
TGCTTGTGTCTGAACTCTAGTGCACTTATGATTTTGTAGACCATGTGAAATTTAATAAGATACCTTTTTTTTCCTTTCTTTGTGTGTAGT
GCAGCAACAGTTTGGTCTGCATTTGTTAGAAGTTTAACTCCTAACAACCCAAAGACCTATTTAACAATTGGTGCATAAATGAAAGTAGTA
CTGTATACTTGAAACTGTTTAAGTACAAGTTGAACAAAAATTATGAAAAGGTATATTTGCTTCTCGGGAAAGCAAAGAAGCTGCTTTAAA
AAATAAAAAGGGGACTAAAAATTTGTTTTGTATAAAGAGGTTAGCCCTGCGCACGTAGGACTGAATTCAGTGATATCCCTATACACTGCC
ATTTAGTGGATAGGTTATTGTACTTCCATTCATACTCTGGGCACTTGTGTTGTATTGTTCTGTTACATACTTTTTTTAACCTGTTTTGTT
TTATCATATATGCATTAAAAGTATTATCTTTATCAACATTTGCTGCTACTGTGTTAACATTTTTGTTTTGCTTGCCATGAATTTCAACTT
CCACCACCCAGTGAATTGATTTATAAATTGCTATGCTTTGCTGTTTTTCTGTTGCTGTGGAACTTAAAGAATGTGAAAGCTGTCAAAGGG
TATTTTACGAATCACTTTTGTGTTTGATATAGTAAAACAATGTGATTCATTCCAAAGTAACAGAAGGTTATTTGTAAGAAAGTTAAAGGC
TTGTGAACAAAGAAAGCTAAGCTGTTGTACATATTTGTAGTTGGCTGTGCATGGTACAAATTTATTAATATGAAGAAATGCAAAATGTAT
TGCTTTTGATATTTCTCTTCCGAGATGAACAAGTAGCATGTAATGCAACTGTTTGACAGTTTAACTCAAGTCATGCTTCAAACTGTTTTA
ATGATCAAATCAAGACACATTTCATTTTACATTTTATTATTGTACAGTTTTTGTTTCGGATGATGATCACAGCAATCTTTATTCTATACA
TTTTATGTGAACTTTTTTAATGTCTTTAATTTGGATTTTTTTTTTTTTTAGTATTTTAACATTTATTTTAATCCTGAAGACACTTTTTTG
ATTGTGTTTCGTAAGAGACAACATGGCCTCCTAAGGTGCAATCCTGCCGCTATAGTGAGCTAATGTCCTGAATCCAAAGGCTTCAGAAAA
TTGCTTTTGCCTTTTTCATGAATGTTAAGCAGCAGCATTGTGAGATCGATCTGTCCTGGCAGTTAACACGATGTGCAACAGTGTGTTAGC
ATGGAACAGAACGCTTTTCACAAAACAAAGGACTGTTTTACAAATGATTATTCCGACAGTGTGTCGACATAAACTTTTACAACTGCACAG
CAGCCAAAAAAAGAAAAAAAAAAGAAAAAAAACTTTAACTGGATGGACGTTGTTAGGGTGAGAAATAAAAGGACAGCCTCCAAAGGTTGA
GAATGAGAATTGTTTTTTCCTGGATATCAAAGGGATTATCACAGCGCAATCATTGTCTACACAACATGTACTCTCAACGCCTGGGTTACA
TAGGAAATGCACCCTGAGGTTTTAATAAAAGCCCCTATGGCTATAACTTTAAATAAACTAAACCAAAAATGTTATTGATGTTTTATATAT
AGAGAGTAGTCTCATTAGTTTTTGTTACTGTAATGTTTGAAGTCTCAAATGCACCGTATTACGGTAAATAACATGGTTTTGAAAACTTTT
TTTTATTTTGTCACAGACCTGTTGTCATAGTTGAAATGATGTTTATTGTAGATGGTATTTGAACTTATTCTTCTGGAAATAGTTCATCAA

>54411_54411_1_MMP16-ZFHX4_MMP16_chr8_89086833_ENST00000286614_ZFHX4_chr8_77745574_ENST00000521891_length(amino acids)=2943AA_BP=1326
MKGNEGGRERERGRKRRGARPSIEAQFTMILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSV
LRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAI
RRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFL
VAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGR
PSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKETASLGARTCDDDLT
EQQLRSTSEEQSEEAEGAIKPTAVAEDDEKDTSERDNSEGKNSNKDSGIITPEKELKVSVAGGTQPLLLAKEEDVATKRSKPTEDNKFCH
EQFYQCPYCNYNSRDQSRIQMHVLSQHSVQPVICCPLCQDVLSNKMHLQLHLTHLHSVSPDCVEKLLMTVPVPDVMMPNSMLLPAAASEK
SERDTPAAVTAEGSGKYSGESPMDDKSMAGLEDSKANVEVKNEEQKPTKEPLEVSEWNKNSSKDVKIPDTLQDQLNEQQKRQPLSVSDRH
VYKYRCNHCSLAFKTMQKLQIHSQYHAIRAATMCNLCQRSFRTFQALKKHLEAGHPELSEAELQQLYASLPVNGELWAESETMSQDDHGL
EQEMEREYEVDHEGKASPVGSDSSSIPDDMGSEPKRTLPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNILLVHYNSVSHLHKLKKVL
QEASSPVPQETNSNTDNKPYKCSICNVAYSQSSTLEIHMRSVLHQTKARAAKLEPSGHVAGGHSIAANVNSPGQGMLDSMSLAAVNSKDT
HLDAKELNKKQTPDLISAQPAHHPPQSPAQIQMQLQHELQQQAAFFQPQFLNPAFLPHFPMTPEALLQFQQPQFLFPFYIPGTEFSLGPD
LGLPGSATFGMPGMTGMAGSLLEDLKQQIQTQHHVGQTQLQILQQQAQQYQATQPQLQPQKQQQQPPPPQQQQQQQASKLLKQEQSNIVS
ADCQIMKDVPSYKEAEDISEKPEKPKQEFISEGEGLKEGKDTKKQKSLEPSIPPPRIASGARGNAAKALLENFGFELVIQYNENRQKVQK
KGKSGEGENTDKLECGTCGKLFSNVLILKSHQEHVHGQFFPYAALEKFARQYREAYDKLYPISPSSPETPPPPPPPPPLPPAPPQPSSMG
PVKIPNTVSTPLQAPPPTPPPPPPPPPPPPPPPPPPPPSAPPQVQLPVSLDLPLFPSIMMQPVQHPALPPQLALQLPQMDALSADLTQLC
QQQLGLDPNFLRHSQFKRPRTRITDDQLKILRAYFDINNSPSEEQIQEMAEKSGLSQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITVL
EDIRIDPQPTSLEHYKSDASFSKRSSRTRFTDYQLRVLQDFFDTNAYPKDDEIEQLSTVLNLPTRVIVVWFQNARQKARKSYENQAETKD
NEKRELTNERYIRTSNMQYQCKKCNVVFPRIFDLITHQKKQCYKDEDDDAQDESQTEDSMDATDQVVYKHCTVSGQTDAAKNAAAPAASS
GSGTSTPLIPSPKPEPEKTSPKPEYPAEKPKQSDPSPPSQGTKPALPLASTSSDPPQASTAQPQPQPQPPKQPQLIGRPPSASQTPVPSS
PLQISMTSLQNSLPPQLLQYQCDQCTVAFPTLELWQEHQHMHFLAAQNQFLHSPFLERPMDMPYMIFDPNNPLMTGQLLGSSLTQMPPQA
SSSHTTAPTTVAASLKRKLDDKEDNNCSEKEGGNSGEDQHRDKRLRTTITPEQLEILYEKYLLDSNPTRKMLDHIAREVGLKKRVVQVWF
QNTRARERKGQFRAVGPAQSHKRCPFCRALFKAKSALESHIRSRHWNEGKQAGYSLPPSPLISTEDGGESPQKYIYFDYPSLPLTKIDLS
SENELASTVSTPVSKTAELSPKNLLSPSSFKAECSEDVENLNAPPAEAGYDQNKTDFDETSSINTAISDATTGDEGNTEMESTTGSSGDV
KPALSPKEPKTLDTLPKPATTPTTEVCDDKFLFSLTSPSIHFNDKDGDHDQSFYITDDPDDNADRSETSSIADPSSPNPFGSSNPFKSKS
NDRPGHKRFRTQMSNLQLKVLKACFSDYRTPTMQECEMLGNEIGLPKRVVQVWFQNARAKEKKFKINIGKPFMINQGGTEGTKPECTLCG
VKYSARLSIRDHIFSKQHISKVRETVGSQLDREKDYLAPTTVRQLMAQQELDRIKKASDVLGLTVQQPGMMDSSSLHGISLPTAYPGLPG
LPPVLLPGMNGPSSLPGFPQNSNTLTPPGAGMLGFPTSATSSPALSLSSAPTKPLLQTPPPPPPPPPPPPSSSLSGQQTEQQNKESEKKQ
TKPNKVKKIKEEELEATKPEKHPKKEEKISSALSVLGKVVGETHVDPIQLQALQNAIAGDPASFIGGQFLPYFIPGFASYFTPQLPGTVQ
GGYFPPVCGMESLFPYGPTMPQTLAGLSPGALLQQYQQYQQNLQESLQKQQKQQQEQQQKPVQAKTSKVESDQPQNSNDASETKEDKSTA
TESTKEEPQLESKSADFSDTYVVPFVKYEFICRKCQMMFTDEDAAVNHQKSFCYFGQPLIDPQETVLRVPVSKYQCLACDVAISGNEALS
QHLQSSLHKEKTIKQAMRNAKEHVRLLPHSVCSPNPNTTSTSQSAASSNNTYPHLSCFSMKSWPNILFQASARRAASPPSSPPSLSLPST

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Fusion Gene PPI Analysis for MMP16-ZFHX4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MMP16-ZFHX4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MMP16-ZFHX4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource