FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MMP17-NOC4L (FusionGDB2 ID:54412)

Fusion Gene Summary for MMP17-NOC4L

check button Fusion gene summary
Fusion gene informationFusion gene name: MMP17-NOC4L
Fusion gene ID: 54412
HgeneTgene
Gene symbol

MMP17

NOC4L

Gene ID

4326

79050

Gene namematrix metallopeptidase 17nucleolar complex associated 4 homolog
SynonymsMMP-17|MT4-MMP|MT4MMP|MTMMP4NET49|NOC4|UTP19
Cytomap

12q24.33

12q24.33

Type of geneprotein-codingprotein-coding
Descriptionmatrix metalloproteinase-17MT-MMP 4matrix metallopeptidase 17 (membrane-inserted)matrix metalloproteinase 17 (membrane-inserted)membrane-type matrix metalloproteinase 4membrane-type-4 matrix metalloproteinasenucleolar complex protein 4 homologNOC4 protein homologNOC4-like proteinnucleolar complex-associated protein 4-like protein
Modification date2020031320200313
UniProtAcc

Q9ULZ9

Q9BVI4

Ensembl transtripts involved in fusion geneENST00000360564, ENST00000535004, 
ENST00000535182, ENST00000535291, 
ENST00000535343, ENST00000538784, 
ENST00000330579, 
Fusion gene scores* DoF score1 X 1 X 4=436 X 4 X 20=2880
# samples 441
** MAII scorelog2(4/4*10)=3.32192809488736log2(41/2880*10)=-2.81237299682423
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MMP17 [Title/Abstract] AND NOC4L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMMP17(132313198)-NOC4L(132635526), # samples:12
Anticipated loss of major functional domain due to fusion event.MMP17-NOC4L seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MMP17-NOC4L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MMP17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NOC4L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1J9-01AMMP17chr12

132313198

+NOC4Lchr12

132635526

+
ChimerDB4ESCATCGA-IG-A8O2MMP17chr12

132313198

+NOC4Lchr12

132635525

+
ChimerDB4ESCATCGA-LN-A4A4MMP17chr12

132313198

+NOC4Lchr12

132635525

+
ChimerDB4ESCATCGA-Z6-A8JDMMP17chr12

132313198

+NOC4Lchr12

132635525

+
ChimerDB4LGGTCGA-WY-A859MMP17chr12

132313198

+NOC4Lchr12

132635802

+
ChimerDB4OVTCGA-24-2019MMP17chr12

132313198

+NOC4Lchr12

132635525

+
ChimerDB4SKCMTCGA-D3-A51J-06AMMP17chr12

132313198

+NOC4Lchr12

132635526

+
ChimerDB4SKCMTCGA-DA-A1I0-06AMMP17chr12

132313198

+NOC4Lchr12

132635526

+
ChimerDB4SKCMTCGA-DA-A1I5-06AMMP17chr12

132313198

+NOC4Lchr12

132635526

+
ChimerDB4SKCMTCGA-DA-A95Y-06AMMP17chr12

132313198

+NOC4Lchr12

132635526

+
ChimerDB4SKCMTCGA-EB-A3Y7-01AMMP17chr12

132313198

+NOC4Lchr12

132635526

+
ChimerDB4SKCMTCGA-EB-A3Y7-01AMMP17chr12

132313198

+NOC4Lchr12

132635803

+
ChimerDB4SKCMTCGA-EB-A6L9-06AMMP17chr12

132313198

+NOC4Lchr12

132635526

+
ChimerDB4SKCMTCGA-ER-A193-06AMMP17chr12

132313198

+NOC4Lchr12

132635526

+
ChimerDB4SKCMTCGA-FS-A1ZY-06AMMP17chr12

132313198

+NOC4Lchr12

132635526

+
ChimerDB4UVMTCGA-V4-A9EXMMP17chr12

132313198

+NOC4Lchr12

132635526

+
ChimerDB4UVMTCGA-VD-AA8SMMP17chr12

132313198

+NOC4Lchr12

132635525

+
ChimerDB4UVMTCGA-VD-AA8SMMP17chr12

132313198

+NOC4Lchr12

132635526

+
ChimerDB4UVMTCGA-WC-A880MMP17chr12

132313198

+NOC4Lchr12

132635526

+


Top

Fusion Gene ORF analysis for MMP17-NOC4L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000360564ENST00000535343MMP17chr12

132313198

+NOC4Lchr12

132635802

+
5CDS-3UTRENST00000360564ENST00000535343MMP17chr12

132313198

+NOC4Lchr12

132635803

+
5CDS-5UTRENST00000360564ENST00000538784MMP17chr12

132313198

+NOC4Lchr12

132635526

+
5CDS-5UTRENST00000360564ENST00000538784MMP17chr12

132313198

+NOC4Lchr12

132635525

+
5CDS-5UTRENST00000360564ENST00000538784MMP17chr12

132313198

+NOC4Lchr12

132635802

+
5CDS-5UTRENST00000360564ENST00000538784MMP17chr12

132313198

+NOC4Lchr12

132635803

+
5CDS-intronENST00000360564ENST00000535343MMP17chr12

132313198

+NOC4Lchr12

132635526

+
5CDS-intronENST00000360564ENST00000535343MMP17chr12

132313198

+NOC4Lchr12

132635525

+
Frame-shiftENST00000360564ENST00000330579MMP17chr12

132313198

+NOC4Lchr12

132635526

+
Frame-shiftENST00000360564ENST00000330579MMP17chr12

132313198

+NOC4Lchr12

132635525

+
Frame-shiftENST00000360564ENST00000330579MMP17chr12

132313198

+NOC4Lchr12

132635802

+
Frame-shiftENST00000360564ENST00000330579MMP17chr12

132313198

+NOC4Lchr12

132635803

+
intron-3CDSENST00000535004ENST00000330579MMP17chr12

132313198

+NOC4Lchr12

132635526

+
intron-3CDSENST00000535004ENST00000330579MMP17chr12

132313198

+NOC4Lchr12

132635525

+
intron-3CDSENST00000535004ENST00000330579MMP17chr12

132313198

+NOC4Lchr12

132635802

+
intron-3CDSENST00000535004ENST00000330579MMP17chr12

132313198

+NOC4Lchr12

132635803

+
intron-3CDSENST00000535182ENST00000330579MMP17chr12

132313198

+NOC4Lchr12

132635526

+
intron-3CDSENST00000535182ENST00000330579MMP17chr12

132313198

+NOC4Lchr12

132635525

+
intron-3CDSENST00000535182ENST00000330579MMP17chr12

132313198

+NOC4Lchr12

132635802

+
intron-3CDSENST00000535182ENST00000330579MMP17chr12

132313198

+NOC4Lchr12

132635803

+
intron-3CDSENST00000535291ENST00000330579MMP17chr12

132313198

+NOC4Lchr12

132635526

+
intron-3CDSENST00000535291ENST00000330579MMP17chr12

132313198

+NOC4Lchr12

132635525

+
intron-3CDSENST00000535291ENST00000330579MMP17chr12

132313198

+NOC4Lchr12

132635802

+
intron-3CDSENST00000535291ENST00000330579MMP17chr12

132313198

+NOC4Lchr12

132635803

+
intron-3UTRENST00000535004ENST00000535343MMP17chr12

132313198

+NOC4Lchr12

132635802

+
intron-3UTRENST00000535004ENST00000535343MMP17chr12

132313198

+NOC4Lchr12

132635803

+
intron-3UTRENST00000535182ENST00000535343MMP17chr12

132313198

+NOC4Lchr12

132635802

+
intron-3UTRENST00000535182ENST00000535343MMP17chr12

132313198

+NOC4Lchr12

132635803

+
intron-3UTRENST00000535291ENST00000535343MMP17chr12

132313198

+NOC4Lchr12

132635802

+
intron-3UTRENST00000535291ENST00000535343MMP17chr12

132313198

+NOC4Lchr12

132635803

+
intron-5UTRENST00000535004ENST00000538784MMP17chr12

132313198

+NOC4Lchr12

132635526

+
intron-5UTRENST00000535004ENST00000538784MMP17chr12

132313198

+NOC4Lchr12

132635525

+
intron-5UTRENST00000535004ENST00000538784MMP17chr12

132313198

+NOC4Lchr12

132635802

+
intron-5UTRENST00000535004ENST00000538784MMP17chr12

132313198

+NOC4Lchr12

132635803

+
intron-5UTRENST00000535182ENST00000538784MMP17chr12

132313198

+NOC4Lchr12

132635526

+
intron-5UTRENST00000535182ENST00000538784MMP17chr12

132313198

+NOC4Lchr12

132635525

+
intron-5UTRENST00000535182ENST00000538784MMP17chr12

132313198

+NOC4Lchr12

132635802

+
intron-5UTRENST00000535182ENST00000538784MMP17chr12

132313198

+NOC4Lchr12

132635803

+
intron-5UTRENST00000535291ENST00000538784MMP17chr12

132313198

+NOC4Lchr12

132635526

+
intron-5UTRENST00000535291ENST00000538784MMP17chr12

132313198

+NOC4Lchr12

132635525

+
intron-5UTRENST00000535291ENST00000538784MMP17chr12

132313198

+NOC4Lchr12

132635802

+
intron-5UTRENST00000535291ENST00000538784MMP17chr12

132313198

+NOC4Lchr12

132635803

+
intron-intronENST00000535004ENST00000535343MMP17chr12

132313198

+NOC4Lchr12

132635526

+
intron-intronENST00000535004ENST00000535343MMP17chr12

132313198

+NOC4Lchr12

132635525

+
intron-intronENST00000535182ENST00000535343MMP17chr12

132313198

+NOC4Lchr12

132635526

+
intron-intronENST00000535182ENST00000535343MMP17chr12

132313198

+NOC4Lchr12

132635525

+
intron-intronENST00000535291ENST00000535343MMP17chr12

132313198

+NOC4Lchr12

132635526

+
intron-intronENST00000535291ENST00000535343MMP17chr12

132313198

+NOC4Lchr12

132635525

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for MMP17-NOC4L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for MMP17-NOC4L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:132313198/:132635526)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MMP17

Q9ULZ9

NOC4L

Q9BVI4

FUNCTION: Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for MMP17-NOC4L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for MMP17-NOC4L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MMP17-NOC4L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MMP17-NOC4L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource