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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MOB1B-MUC7 (FusionGDB2 ID:54488)

Fusion Gene Summary for MOB1B-MUC7

check button Fusion gene summary
Fusion gene informationFusion gene name: MOB1B-MUC7
Fusion gene ID: 54488
HgeneTgene
Gene symbol

MOB1B

MUC7

Gene ID

92597

4589

Gene nameMOB kinase activator 1Bmucin 7, secreted
SynonymsMATS2|MOB4A|MOBKL1AMG2
Cytomap

4q13.3

4q13.3

Type of geneprotein-codingprotein-coding
DescriptionMOB kinase activator 1BMOB1 Mps One Binder homolog BMOB1, Mps One Binder kinase activator-like 1Amob1 homolog 1Amob1Amps one binder kinase activator-like 1Amucin-7MUC-7apo-MG2mucin 7, salivarysalivary mucin-7
Modification date2020032020200313
UniProtAcc

Q7L9L4

Q8TAX7

Ensembl transtripts involved in fusion geneENST00000511449, ENST00000309395, 
ENST00000396051, 		ENST00000514512, 
ENST00000304887, ENST00000413702, 
ENST00000456088, 
Fusion gene scores* DoF score9 X 3 X 8=2166 X 8 X 4=192
# samples 117
** MAII scorelog2(11/216*10)=-0.973527788638809
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/192*10)=-1.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MOB1B [Title/Abstract] AND MUC7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMOB1B(71768267)-MUC7(71337932), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMOB1B

GO:0031952

regulation of protein autophosphorylation

15197186

HgeneMOB1B

GO:0035329

hippo signaling

19739119

TgeneMUC7

GO:0031640

killing of cells of other organism

12543672

TgeneMUC7

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

12543672


check buttonFusion gene breakpoints across MOB1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MUC7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1322-01AMOB1Bchr4

71768267

+MUC7chr4

71296301

+
ChimerDB4OVTCGA-25-1322-01AMOB1Bchr4

71768267

+MUC7chr4

71337932

+


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Fusion Gene ORF analysis for MOB1B-MUC7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000511449ENST00000514512MOB1Bchr4

71768267

+MUC7chr4

71337932

+
3UTR-5UTRENST00000511449ENST00000304887MOB1Bchr4

71768267

+MUC7chr4

71337932

+
3UTR-5UTRENST00000511449ENST00000413702MOB1Bchr4

71768267

+MUC7chr4

71296301

+
3UTR-5UTRENST00000511449ENST00000413702MOB1Bchr4

71768267

+MUC7chr4

71337932

+
3UTR-5UTRENST00000511449ENST00000456088MOB1Bchr4

71768267

+MUC7chr4

71337932

+
3UTR-intronENST00000511449ENST00000304887MOB1Bchr4

71768267

+MUC7chr4

71296301

+
3UTR-intronENST00000511449ENST00000456088MOB1Bchr4

71768267

+MUC7chr4

71296301

+
3UTR-intronENST00000511449ENST00000514512MOB1Bchr4

71768267

+MUC7chr4

71296301

+
5CDS-3UTRENST00000309395ENST00000514512MOB1Bchr4

71768267

+MUC7chr4

71337932

+
5CDS-5UTRENST00000309395ENST00000304887MOB1Bchr4

71768267

+MUC7chr4

71337932

+
5CDS-5UTRENST00000309395ENST00000413702MOB1Bchr4

71768267

+MUC7chr4

71296301

+
5CDS-5UTRENST00000309395ENST00000413702MOB1Bchr4

71768267

+MUC7chr4

71337932

+
5CDS-5UTRENST00000309395ENST00000456088MOB1Bchr4

71768267

+MUC7chr4

71337932

+
5CDS-intronENST00000309395ENST00000304887MOB1Bchr4

71768267

+MUC7chr4

71296301

+
5CDS-intronENST00000309395ENST00000456088MOB1Bchr4

71768267

+MUC7chr4

71296301

+
5CDS-intronENST00000309395ENST00000514512MOB1Bchr4

71768267

+MUC7chr4

71296301

+
5UTR-3UTRENST00000396051ENST00000514512MOB1Bchr4

71768267

+MUC7chr4

71337932

+
5UTR-5UTRENST00000396051ENST00000304887MOB1Bchr4

71768267

+MUC7chr4

71337932

+
5UTR-5UTRENST00000396051ENST00000413702MOB1Bchr4

71768267

+MUC7chr4

71296301

+
5UTR-5UTRENST00000396051ENST00000413702MOB1Bchr4

71768267

+MUC7chr4

71337932

+
5UTR-5UTRENST00000396051ENST00000456088MOB1Bchr4

71768267

+MUC7chr4

71337932

+
5UTR-intronENST00000396051ENST00000304887MOB1Bchr4

71768267

+MUC7chr4

71296301

+
5UTR-intronENST00000396051ENST00000456088MOB1Bchr4

71768267

+MUC7chr4

71296301

+
5UTR-intronENST00000396051ENST00000514512MOB1Bchr4

71768267

+MUC7chr4

71296301

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MOB1B-MUC7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MOB1B-MUC7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:71768267/:71337932)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MOB1B

Q7L9L4

MUC7

Q8TAX7

FUNCTION: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:19739119}.FUNCTION: May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili. {ECO:0000269|PubMed:11378823, ECO:0000269|PubMed:8104046}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MOB1B-MUC7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MOB1B-MUC7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MOB1B-MUC7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MOB1B-MUC7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource