FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MOB4-COQ10B (FusionGDB2 ID:54518)

Fusion Gene Summary for MOB4-COQ10B

check button Fusion gene summary
Fusion gene informationFusion gene name: MOB4-COQ10B
Fusion gene ID: 54518
HgeneTgene
Gene symbol

MOB4

COQ10B

Gene ID

25843

80219

Gene nameMOB family member 4, phoceincoenzyme Q10B
Synonyms2C4D|CGI-95|MOB1|MOB3|MOBKL3|PHOCN|PREI3-
Cytomap

2q33.1

2q33.1

Type of geneprotein-codingprotein-coding
DescriptionMOB-like protein phoceinMOB1, Mps One Binder kinase activator-like 3Mps One Binder kinase activator-like 3class II mMOB1mob1 homolog 3phocein, Mob-like proteinpreimplantation protein 3coenzyme Q-binding protein COQ10 homolog B, mitochondrialcoenzyme Q10 homolog B
Modification date2020031320200313
UniProtAcc

Q9Y3A3

Q9H8M1

Ensembl transtripts involved in fusion geneENST00000497443, ENST00000233892, 
ENST00000323303, ENST00000409360, 
ENST00000409916, ENST00000448447, 
ENST00000263960, ENST00000409398, 
ENST00000409010, ENST00000488445, 
ENST00000545340, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 2 X 3=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MOB4 [Title/Abstract] AND COQ10B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMOB4(198405161)-COQ10B(198334794), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MOB4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COQ10B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-C5-A7X5-01AMOB4chr2

198405161

+COQ10Bchr2

198334794

+


Top

Fusion Gene ORF analysis for MOB4-COQ10B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000497443ENST00000263960MOB4chr2

198405161

+COQ10Bchr2

198334794

+
3UTR-3CDSENST00000497443ENST00000409398MOB4chr2

198405161

+COQ10Bchr2

198334794

+
3UTR-intronENST00000497443ENST00000409010MOB4chr2

198405161

+COQ10Bchr2

198334794

+
3UTR-intronENST00000497443ENST00000488445MOB4chr2

198405161

+COQ10Bchr2

198334794

+
3UTR-intronENST00000497443ENST00000545340MOB4chr2

198405161

+COQ10Bchr2

198334794

+
5CDS-intronENST00000233892ENST00000409010MOB4chr2

198405161

+COQ10Bchr2

198334794

+
5CDS-intronENST00000233892ENST00000488445MOB4chr2

198405161

+COQ10Bchr2

198334794

+
5CDS-intronENST00000233892ENST00000545340MOB4chr2

198405161

+COQ10Bchr2

198334794

+
5CDS-intronENST00000323303ENST00000409010MOB4chr2

198405161

+COQ10Bchr2

198334794

+
5CDS-intronENST00000323303ENST00000488445MOB4chr2

198405161

+COQ10Bchr2

198334794

+
5CDS-intronENST00000323303ENST00000545340MOB4chr2

198405161

+COQ10Bchr2

198334794

+
5CDS-intronENST00000409360ENST00000409010MOB4chr2

198405161

+COQ10Bchr2

198334794

+
5CDS-intronENST00000409360ENST00000488445MOB4chr2

198405161

+COQ10Bchr2

198334794

+
5CDS-intronENST00000409360ENST00000545340MOB4chr2

198405161

+COQ10Bchr2

198334794

+
5CDS-intronENST00000409916ENST00000409010MOB4chr2

198405161

+COQ10Bchr2

198334794

+
5CDS-intronENST00000409916ENST00000488445MOB4chr2

198405161

+COQ10Bchr2

198334794

+
5CDS-intronENST00000409916ENST00000545340MOB4chr2

198405161

+COQ10Bchr2

198334794

+
5CDS-intronENST00000448447ENST00000409010MOB4chr2

198405161

+COQ10Bchr2

198334794

+
5CDS-intronENST00000448447ENST00000488445MOB4chr2

198405161

+COQ10Bchr2

198334794

+
5CDS-intronENST00000448447ENST00000545340MOB4chr2

198405161

+COQ10Bchr2

198334794

+
In-frameENST00000233892ENST00000263960MOB4chr2

198405161

+COQ10Bchr2

198334794

+
In-frameENST00000233892ENST00000409398MOB4chr2

198405161

+COQ10Bchr2

198334794

+
In-frameENST00000323303ENST00000263960MOB4chr2

198405161

+COQ10Bchr2

198334794

+
In-frameENST00000323303ENST00000409398MOB4chr2

198405161

+COQ10Bchr2

198334794

+
In-frameENST00000409360ENST00000263960MOB4chr2

198405161

+COQ10Bchr2

198334794

+
In-frameENST00000409360ENST00000409398MOB4chr2

198405161

+COQ10Bchr2

198334794

+
In-frameENST00000409916ENST00000263960MOB4chr2

198405161

+COQ10Bchr2

198334794

+
In-frameENST00000409916ENST00000409398MOB4chr2

198405161

+COQ10Bchr2

198334794

+
In-frameENST00000448447ENST00000263960MOB4chr2

198405161

+COQ10Bchr2

198334794

+
In-frameENST00000448447ENST00000409398MOB4chr2

198405161

+COQ10Bchr2

198334794

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for MOB4-COQ10B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for MOB4-COQ10B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:198405161/chr2:198334794)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MOB4

Q9Y3A3

COQ10B

Q9H8M1

FUNCTION: May play a role in membrane trafficking, specifically in membrane budding reactions. {ECO:0000250}.FUNCTION: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for MOB4-COQ10B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for MOB4-COQ10B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MOB4-COQ10B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MOB4-COQ10B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource