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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MOB4-HSPE1 (FusionGDB2 ID:54519)

Fusion Gene Summary for MOB4-HSPE1

check button Fusion gene summary
Fusion gene informationFusion gene name: MOB4-HSPE1
Fusion gene ID: 54519
HgeneTgene
Gene symbol

MOB4

HSPE1

Gene ID

25843

3336

Gene nameMOB family member 4, phoceinheat shock protein family E (Hsp10) member 1
Synonyms2C4D|CGI-95|MOB1|MOB3|MOBKL3|PHOCN|PREI3CPN10|EPF|GROES|HSP10
Cytomap

2q33.1

2q33.1

Type of geneprotein-codingprotein-coding
DescriptionMOB-like protein phoceinMOB1, Mps One Binder kinase activator-like 3Mps One Binder kinase activator-like 3class II mMOB1mob1 homolog 3phocein, Mob-like proteinpreimplantation protein 310 kDa heat shock protein, mitochondrial10 kDa chaperoninchaperonin 10early-pregnancy factorepididymis secretory sperm binding proteinheat shock 10kD protein 1 (chaperonin 10)heat shock 10kDa protein 1
Modification date2020031320200313
UniProtAcc

Q9Y3A3

P61604

Ensembl transtripts involved in fusion geneENST00000497443, ENST00000323303, 
ENST00000448447, ENST00000233892, 
ENST00000409360, ENST00000409916, 
ENST00000233893, ENST00000409468, 
ENST00000409729, ENST00000465573, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: MOB4 [Title/Abstract] AND HSPE1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMOB4(198380870)-HSPE1(198367762), # samples:1
Anticipated loss of major functional domain due to fusion event.MOB4-HSPE1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MOB4-HSPE1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MOB4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HSPE1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0899MOB4chr2

198380870

+HSPE1chr2

198367762

+


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Fusion Gene ORF analysis for MOB4-HSPE1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000497443ENST00000233893MOB4chr2

198380870

+HSPE1chr2

198367762

+
3UTR-3CDSENST00000497443ENST00000409468MOB4chr2

198380870

+HSPE1chr2

198367762

+
3UTR-3CDSENST00000497443ENST00000409729MOB4chr2

198380870

+HSPE1chr2

198367762

+
3UTR-3UTRENST00000497443ENST00000465573MOB4chr2

198380870

+HSPE1chr2

198367762

+
5CDS-3UTRENST00000323303ENST00000465573MOB4chr2

198380870

+HSPE1chr2

198367762

+
5CDS-3UTRENST00000448447ENST00000465573MOB4chr2

198380870

+HSPE1chr2

198367762

+
Frame-shiftENST00000323303ENST00000409468MOB4chr2

198380870

+HSPE1chr2

198367762

+
Frame-shiftENST00000448447ENST00000409468MOB4chr2

198380870

+HSPE1chr2

198367762

+
In-frameENST00000323303ENST00000233893MOB4chr2

198380870

+HSPE1chr2

198367762

+
In-frameENST00000323303ENST00000409729MOB4chr2

198380870

+HSPE1chr2

198367762

+
In-frameENST00000448447ENST00000233893MOB4chr2

198380870

+HSPE1chr2

198367762

+
In-frameENST00000448447ENST00000409729MOB4chr2

198380870

+HSPE1chr2

198367762

+
intron-3CDSENST00000233892ENST00000233893MOB4chr2

198380870

+HSPE1chr2

198367762

+
intron-3CDSENST00000233892ENST00000409468MOB4chr2

198380870

+HSPE1chr2

198367762

+
intron-3CDSENST00000233892ENST00000409729MOB4chr2

198380870

+HSPE1chr2

198367762

+
intron-3CDSENST00000409360ENST00000233893MOB4chr2

198380870

+HSPE1chr2

198367762

+
intron-3CDSENST00000409360ENST00000409468MOB4chr2

198380870

+HSPE1chr2

198367762

+
intron-3CDSENST00000409360ENST00000409729MOB4chr2

198380870

+HSPE1chr2

198367762

+
intron-3CDSENST00000409916ENST00000233893MOB4chr2

198380870

+HSPE1chr2

198367762

+
intron-3CDSENST00000409916ENST00000409468MOB4chr2

198380870

+HSPE1chr2

198367762

+
intron-3CDSENST00000409916ENST00000409729MOB4chr2

198380870

+HSPE1chr2

198367762

+
intron-3UTRENST00000233892ENST00000465573MOB4chr2

198380870

+HSPE1chr2

198367762

+
intron-3UTRENST00000409360ENST00000465573MOB4chr2

198380870

+HSPE1chr2

198367762

+
intron-3UTRENST00000409916ENST00000465573MOB4chr2

198380870

+HSPE1chr2

198367762

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MOB4-HSPE1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MOB4-HSPE1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:198380870/chr2:198367762)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MOB4

Q9Y3A3

HSPE1

P61604

FUNCTION: May play a role in membrane trafficking, specifically in membrane budding reactions. {ECO:0000250}.FUNCTION: Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:7912672, PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000269|PubMed:7912672, ECO:0000305|PubMed:25918392}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MOB4-HSPE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MOB4-HSPE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MOB4-HSPE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MOB4-HSPE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource