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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MOCS1-LEMD3 (FusionGDB2 ID:54537)

Fusion Gene Summary for MOCS1-LEMD3

check button Fusion gene summary
Fusion gene informationFusion gene name: MOCS1-LEMD3
Fusion gene ID: 54537
HgeneTgene
Gene symbol

MOCS1

LEMD3

Gene ID

4337

23592

Gene namemolybdenum cofactor synthesis 1LEM domain containing 3
SynonymsMIG11|MOCOD|MOCS1A|MOCS1BMAN1
Cytomap

6p21.2

12q14.3

Type of geneprotein-codingprotein-coding
Descriptionmolybdenum cofactor biosynthesis protein 1MOCS1A enzymecell migration-inducing gene 11 proteinmolybdenum cofactor biosynthesis protein Amolybdenum cofactor synthesis-step 1 protein A-Binner nuclear membrane protein Man1LEM domain-containing protein 3LEMD3/MKX fusionintegral inner nuclear membrane protein
Modification date2020032020200313
UniProtAcc

Q9NZB8

Q9Y2U8

Ensembl transtripts involved in fusion geneENST00000308559, ENST00000340692, 
ENST00000373175, ENST00000373186, 
ENST00000373188, ENST00000373195, 
ENST00000425303, ENST00000432280, 
ENST00000541171, ENST00000308330, 
Fusion gene scores* DoF score2 X 3 X 2=124 X 5 X 5=100
# samples 36
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MOCS1 [Title/Abstract] AND LEMD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMOCS1(39893422)-LEMD3(65632282), # samples:3
Anticipated loss of major functional domain due to fusion event.MOCS1-LEMD3 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MOCS1-LEMD3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLEMD3

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

15647271

TgeneLEMD3

GO:0030514

negative regulation of BMP signaling pathway

15647271

TgeneLEMD3

GO:0032926

negative regulation of activin receptor signaling pathway

15647271


check buttonFusion gene breakpoints across MOCS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LEMD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-A5NZ-01AMOCS1chr6

39893422

-LEMD3chr12

65632282

+
ChimerDB4OVTCGA-29-A5NZMOCS1chr6

39893421

-LEMD3chr12

65632281

+


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Fusion Gene ORF analysis for MOCS1-LEMD3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000308559ENST00000541171MOCS1chr6

39893422

-LEMD3chr12

65632282

+
5CDS-intronENST00000308559ENST00000541171MOCS1chr6

39893421

-LEMD3chr12

65632281

+
5CDS-intronENST00000340692ENST00000541171MOCS1chr6

39893422

-LEMD3chr12

65632282

+
5CDS-intronENST00000340692ENST00000541171MOCS1chr6

39893421

-LEMD3chr12

65632281

+
5CDS-intronENST00000373175ENST00000541171MOCS1chr6

39893422

-LEMD3chr12

65632282

+
5CDS-intronENST00000373175ENST00000541171MOCS1chr6

39893421

-LEMD3chr12

65632281

+
5CDS-intronENST00000373186ENST00000541171MOCS1chr6

39893422

-LEMD3chr12

65632282

+
5CDS-intronENST00000373186ENST00000541171MOCS1chr6

39893421

-LEMD3chr12

65632281

+
5CDS-intronENST00000373188ENST00000541171MOCS1chr6

39893422

-LEMD3chr12

65632282

+
5CDS-intronENST00000373188ENST00000541171MOCS1chr6

39893421

-LEMD3chr12

65632281

+
5CDS-intronENST00000373195ENST00000541171MOCS1chr6

39893422

-LEMD3chr12

65632282

+
5CDS-intronENST00000373195ENST00000541171MOCS1chr6

39893421

-LEMD3chr12

65632281

+
5CDS-intronENST00000425303ENST00000541171MOCS1chr6

39893422

-LEMD3chr12

65632282

+
5CDS-intronENST00000425303ENST00000541171MOCS1chr6

39893421

-LEMD3chr12

65632281

+
5CDS-intronENST00000432280ENST00000541171MOCS1chr6

39893422

-LEMD3chr12

65632282

+
5CDS-intronENST00000432280ENST00000541171MOCS1chr6

39893421

-LEMD3chr12

65632281

+
Frame-shiftENST00000308559ENST00000308330MOCS1chr6

39893422

-LEMD3chr12

65632282

+
Frame-shiftENST00000308559ENST00000308330MOCS1chr6

39893421

-LEMD3chr12

65632281

+
Frame-shiftENST00000340692ENST00000308330MOCS1chr6

39893422

-LEMD3chr12

65632282

+
Frame-shiftENST00000340692ENST00000308330MOCS1chr6

39893421

-LEMD3chr12

65632281

+
Frame-shiftENST00000373175ENST00000308330MOCS1chr6

39893422

-LEMD3chr12

65632282

+
Frame-shiftENST00000373175ENST00000308330MOCS1chr6

39893421

-LEMD3chr12

65632281

+
Frame-shiftENST00000373188ENST00000308330MOCS1chr6

39893422

-LEMD3chr12

65632282

+
Frame-shiftENST00000373188ENST00000308330MOCS1chr6

39893421

-LEMD3chr12

65632281

+
Frame-shiftENST00000373195ENST00000308330MOCS1chr6

39893422

-LEMD3chr12

65632282

+
Frame-shiftENST00000373195ENST00000308330MOCS1chr6

39893421

-LEMD3chr12

65632281

+
Frame-shiftENST00000425303ENST00000308330MOCS1chr6

39893422

-LEMD3chr12

65632282

+
Frame-shiftENST00000425303ENST00000308330MOCS1chr6

39893421

-LEMD3chr12

65632281

+
Frame-shiftENST00000432280ENST00000308330MOCS1chr6

39893422

-LEMD3chr12

65632282

+
Frame-shiftENST00000432280ENST00000308330MOCS1chr6

39893421

-LEMD3chr12

65632281

+
In-frameENST00000373186ENST00000308330MOCS1chr6

39893422

-LEMD3chr12

65632282

+
In-frameENST00000373186ENST00000308330MOCS1chr6

39893421

-LEMD3chr12

65632281

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373186MOCS1chr639893422-ENST00000308330LEMD3chr1265632282+35995565501596348
ENST00000373186MOCS1chr639893421-ENST00000308330LEMD3chr1265632281+35995565501596348

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373186ENST00000308330MOCS1chr639893422-LEMD3chr1265632282+0.0002998360.9997002
ENST00000373186ENST00000308330MOCS1chr639893421-LEMD3chr1265632281+0.0002998360.9997002

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Fusion Genomic Features for MOCS1-LEMD3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MOCS1-LEMD3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:39893422/chr12:65632282)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MOCS1

Q9NZB8

LEMD3

Q9Y2U8

FUNCTION: Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP. {ECO:0000269|PubMed:11891227}.FUNCTION: Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLEMD3chr6:39893421chr12:65632281ENST00000308330313635_640565912.0Compositional biasNote=Poly-Leu
TgeneLEMD3chr6:39893421chr12:65632281ENST00000308330313659_662565912.0Compositional biasNote=Poly-Glu
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330313635_640565912.0Compositional biasNote=Poly-Leu
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330313659_662565912.0Compositional biasNote=Poly-Glu
TgeneLEMD3chr6:39893421chr12:65632281ENST00000308330313707_726565912.0DNA binding.
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330313707_726565912.0DNA binding.
TgeneLEMD3chr6:39893421chr12:65632281ENST00000308330313628_648565912.0TransmembraneHelical
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330313628_648565912.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMOCS1chr6:39893421chr12:65632281ENST00000308559-31064_277139621.0DomainRadical SAM core
HgeneMOCS1chr6:39893421chr12:65632281ENST00000340692-31164_277139637.0DomainRadical SAM core
HgeneMOCS1chr6:39893421chr12:65632281ENST00000373175-31164_2771101277.0DomainRadical SAM core
HgeneMOCS1chr6:39893421chr12:65632281ENST00000373186-21064_2771391206.0DomainRadical SAM core
HgeneMOCS1chr6:39893421chr12:65632281ENST00000373188-31164_277139965.3333333333334DomainRadical SAM core
HgeneMOCS1chr6:39893421chr12:65632281ENST00000373195-2964_27752534.0DomainRadical SAM core
HgeneMOCS1chr6:39893421chr12:65632281ENST00000425303-21064_277139637.0DomainRadical SAM core
HgeneMOCS1chr6:39893421chr12:65632281ENST00000432280-31064_277110357.0DomainRadical SAM core
HgeneMOCS1chr6:39893422chr12:65632282ENST00000308559-31064_277139621.0DomainRadical SAM core
HgeneMOCS1chr6:39893422chr12:65632282ENST00000340692-31164_277139637.0DomainRadical SAM core
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373175-31164_2771101277.0DomainRadical SAM core
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373186-21064_2771391206.0DomainRadical SAM core
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373188-31164_277139965.3333333333334DomainRadical SAM core
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373195-2964_27752534.0DomainRadical SAM core
HgeneMOCS1chr6:39893422chr12:65632282ENST00000425303-21064_277139637.0DomainRadical SAM core
HgeneMOCS1chr6:39893422chr12:65632282ENST00000432280-31064_277110357.0DomainRadical SAM core
HgeneMOCS1chr6:39893421chr12:65632281ENST00000308559-3101_383139621.0RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893421chr12:65632281ENST00000308559-310317_319139621.0RegionGTP binding
HgeneMOCS1chr6:39893421chr12:65632281ENST00000308559-310414_636139621.0RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893421chr12:65632281ENST00000340692-3111_383139637.0RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893421chr12:65632281ENST00000340692-311317_319139637.0RegionGTP binding
HgeneMOCS1chr6:39893421chr12:65632281ENST00000340692-311414_636139637.0RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893421chr12:65632281ENST00000373175-3111_3831101277.0RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893421chr12:65632281ENST00000373175-311317_3191101277.0RegionGTP binding
HgeneMOCS1chr6:39893421chr12:65632281ENST00000373175-311414_6361101277.0RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893421chr12:65632281ENST00000373186-2101_3831391206.0RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893421chr12:65632281ENST00000373186-210317_3191391206.0RegionGTP binding
HgeneMOCS1chr6:39893421chr12:65632281ENST00000373186-210414_6361391206.0RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893421chr12:65632281ENST00000373188-3111_383139965.3333333333334RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893421chr12:65632281ENST00000373188-311317_319139965.3333333333334RegionGTP binding
HgeneMOCS1chr6:39893421chr12:65632281ENST00000373188-311414_636139965.3333333333334RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893421chr12:65632281ENST00000373195-291_38352534.0RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893421chr12:65632281ENST00000373195-29317_31952534.0RegionGTP binding
HgeneMOCS1chr6:39893421chr12:65632281ENST00000373195-29414_63652534.0RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893421chr12:65632281ENST00000425303-2101_383139637.0RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893421chr12:65632281ENST00000425303-210317_319139637.0RegionGTP binding
HgeneMOCS1chr6:39893421chr12:65632281ENST00000425303-210414_636139637.0RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893421chr12:65632281ENST00000432280-3101_383110357.0RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893421chr12:65632281ENST00000432280-310317_319110357.0RegionGTP binding
HgeneMOCS1chr6:39893421chr12:65632281ENST00000432280-310414_636110357.0RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893422chr12:65632282ENST00000308559-3101_383139621.0RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893422chr12:65632282ENST00000308559-310317_319139621.0RegionGTP binding
HgeneMOCS1chr6:39893422chr12:65632282ENST00000308559-310414_636139621.0RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893422chr12:65632282ENST00000340692-3111_383139637.0RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893422chr12:65632282ENST00000340692-311317_319139637.0RegionGTP binding
HgeneMOCS1chr6:39893422chr12:65632282ENST00000340692-311414_636139637.0RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373175-3111_3831101277.0RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373175-311317_3191101277.0RegionGTP binding
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373175-311414_6361101277.0RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373186-2101_3831391206.0RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373186-210317_3191391206.0RegionGTP binding
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373186-210414_6361391206.0RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373188-3111_383139965.3333333333334RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373188-311317_319139965.3333333333334RegionGTP binding
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373188-311414_636139965.3333333333334RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373195-291_38352534.0RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373195-29317_31952534.0RegionGTP binding
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373195-29414_63652534.0RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893422chr12:65632282ENST00000425303-2101_383139637.0RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893422chr12:65632282ENST00000425303-210317_319139637.0RegionGTP binding
HgeneMOCS1chr6:39893422chr12:65632282ENST00000425303-210414_636139637.0RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893422chr12:65632282ENST00000432280-3101_383110357.0RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893422chr12:65632282ENST00000432280-310317_319110357.0RegionGTP binding
HgeneMOCS1chr6:39893422chr12:65632282ENST00000432280-310414_636110357.0RegionNote=Molybdenum cofactor biosynthesis protein C
TgeneLEMD3chr6:39893421chr12:65632281ENST00000308330313155_158565912.0Compositional biasNote=Poly-Gly
TgeneLEMD3chr6:39893421chr12:65632281ENST00000308330313265_268565912.0Compositional biasNote=Poly-Asp
TgeneLEMD3chr6:39893421chr12:65632281ENST00000308330313312_315565912.0Compositional biasNote=Poly-Gly
TgeneLEMD3chr6:39893421chr12:65632281ENST00000308330313322_325565912.0Compositional biasNote=Poly-Ala
TgeneLEMD3chr6:39893421chr12:65632281ENST00000308330313337_340565912.0Compositional biasNote=Poly-Ala
TgeneLEMD3chr6:39893421chr12:65632281ENST0000030833031365_70565912.0Compositional biasNote=Poly-Asn
TgeneLEMD3chr6:39893421chr12:65632281ENST0000030833031372_87565912.0Compositional biasNote=Ala-rich
TgeneLEMD3chr6:39893421chr12:65632281ENST0000030833031382_87565912.0Compositional biasNote=Poly-Ala
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330313155_158565912.0Compositional biasNote=Poly-Gly
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330313265_268565912.0Compositional biasNote=Poly-Asp
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330313312_315565912.0Compositional biasNote=Poly-Gly
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330313322_325565912.0Compositional biasNote=Poly-Ala
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330313337_340565912.0Compositional biasNote=Poly-Ala
TgeneLEMD3chr6:39893422chr12:65632282ENST0000030833031365_70565912.0Compositional biasNote=Poly-Asn
TgeneLEMD3chr6:39893422chr12:65632282ENST0000030833031372_87565912.0Compositional biasNote=Ala-rich
TgeneLEMD3chr6:39893422chr12:65632282ENST0000030833031382_87565912.0Compositional biasNote=Poly-Ala
TgeneLEMD3chr6:39893421chr12:65632281ENST000003083303136_50565912.0DomainLEM
TgeneLEMD3chr6:39893422chr12:65632282ENST000003083303136_50565912.0DomainLEM
TgeneLEMD3chr6:39893421chr12:65632281ENST00000308330313475_495565912.0TransmembraneHelical
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330313475_495565912.0TransmembraneHelical


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Fusion Gene Sequence for MOCS1-LEMD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54537_54537_1_MOCS1-LEMD3_MOCS1_chr6_39893421_ENST00000373186_LEMD3_chr12_65632281_ENST00000308330_length(transcript)=3599nt_BP=556nt
GCCAGAAATCTTCCCAGTAGAGATCACCATCCGCCCCCGACCCCCAAGCTGAATACTTAAGGGGTGGGTCCTTCCCATCAAGCTGATTTC
TCAACGAGAGGGACAATCCCAGCTTCCCCAACATTGCAGAGCCCAAACATGTGGAAGAGTTGGAAGCTCCGCACAGATGTCAGAGTAAGG
GAGGGGGCAGGCGGTTCTCCTTGTGCCTCTTCCCAGCCCGGTAGCAGGGGCCCATGCTTCCTCCCTGGTCTGTCCTCGCAGGAGGTGTCC
AGGCGGAGGCAGTTCCTGCGGGAGCATGCGGCCCCCTTCTCCGCCTTCCTCACAGACAGCTTCGGCCGGCAGCACAGCTACCTGCGGATC
TCCCTCACAGAGAAGTGCAACCTCAGATGTCAGTACTGCATGCCCGAGGAGGGGGTCCCGCTGACCCCCAAAGCCAACCTGCTGACCACA
GAGGAGATCCTGACCCTCGCCCGGCTCTTTGTGAAGGAAGGCATCGACAAGATCCGGCTCACAGGTGGAGAGCCGCTTATCCGGCCGGAC
GTGGTGGACATTGTGGGATTTAGGTCCTGAATATGAAGGTATATTTAACACTTCATTGCAGTGGATCTTAGAAAATGGAAAAGATGTTGG
AATAAGGTGTGTTGGTTTTGGCCCTGAGGAAGAATTGACAAATATAACTGATGTGCAGTTTTTACAGTCCACAAGACCACTGATGTCTTT
TTGGTGTCGTTTTCGACGTGCTTTTGTTACTGTAACTCACAGATTATTGTTGTTATGCTTAGGTGTAGTGATGGTTTGTGTCGTTCTGCG
TTACATGAAATATCGATGGACAAAAGAAGAGGAGGAAACAAGGCAGATGTATGATATGGTGGTAAAGATTATAGATGTTTTACGAAGTCA
TAATGAAGCCTGCCAGGAAAACAAAGATTTACAACCTTACATGCCTATTCCACATGTACGCGATTCCTTAATACAGCCTCATGACAGGAA
AAAAATGAAGAAAGTCTGGGATAGAGCTGTTGACTTCCTTGCTGCTAATGAGTCTAGAGTTCGCACGGAAACACGAAGAATAGGTGGTGC
AGATTTTCTGGTTTGGCGGTGGATCCAGCCTTCTGCATCCTGTGACAAAATATTAGTTATACCTTCTAAAGTATGGCAAGGTCAAGCATT
TCATTTAGATAGAAGAAATTCACCACCAAATAGTTTGACACCGTGTCTAAAGATTCGGAATATGTTTGATCCCGTTATGGAAATAGGGGA
TCAGTGGCATTTGGCAATTCAAGAAGCAATTTTAGAAAAATGCAGTGATAATGATGGCATTGTTCACATTGCAGTAGACAAAAATTCACG
TGAGGGTTGTGTATATGTTAAATGTCTGTCTCCAGAATATGCTGGAAAGGCTTTTAAAGCATTGCATGGCTCTTGGTTTGATGGGAAATT
GGTTACAGTAAAATATTTACGACTAGATAGATACCACCATCGCTTTCCCCAGGCTCTCACTTCCAACACTCCATTGAAGCCATCAAATAA
ACATATGAACTCCATGTCTCATCTTCGTCTTCGGACTGGCCTAACCAATTCTCAAGGAAGTTCCTGAAAAGATTTTCTTCCATTTCTAAG
ACTGTTATTTACAATAGGAAAATTCCTGTTTGGCTTTTTGTCTTCCTTTTTAAATGCTTTTTGTATGTAATATTTTTATTGATGAATACA
TCTCTGAACGTTCCAGAAGTCTTAAGGTTCCAAAGGGATTTAGCAGTGAGGCAGCAATGCTGAGTAGGTAGGATAATTATTTCATTCAGT
TTTTGGAGCTCAGTTAAGCCAATACATTTAAAGTTTTGCATGAGGAACACTGACTTTATTAAGCATTTTCAGATGTGGTGGTTGTATTTT
TGCCCCAAGAAGTGTTTGGATAACCACACAAAAGCATGATGAAAAGGCTTCTTGTAGTCCCATAATTTCTTGTGAACTAATGTTGTGAAT
TTTTGTATACAGTCACCTGCATAGTTCCTACAGGCTAATGTGGTAAAACTGTTGATTTCCCAATTTAACCTTAGGTTTCTGTTGCTTATA
AGCGATTCATTTGCTACGGCTGGAATATGGGAAAATTAATTTGGGCTTAGTGGTTACAAATATGTGTAAGTGGATGTATATGTACTTAAA
CTGGCTTTGTATATATGTATAAATGCTGGTGGTGGTGAAAGTAGTCTTGTTTTATGAGGATGTCTGCATTAAAGCAGTAAAATAAGCTTT
CCATTTTATTCATAATCTAATGTGTGTGTATATATGTATGTGTGTATGTGTGTGTATATATAGATGTATATATATACACACACAGAGATA
TATACATATGGCTGTACTTTTGCATAGATCAAACAGCCAAACACCTGGAAGTATTAGATACAAGTTTAAAATATCTTTTATAGGTTTTAT
ATAAAAATGTCTGAGTATGATTTTGTGTGAAAGTTCTGATACCAGTTGTAATAGAGTCAAATTTATGTGAGCAATAAAGAAGAAATTGGC
AGATATTGGAAAAATATTTTGTGAAAAGCTGTATTTATTATAAATACTAGGGCCATGACATAGTACCATTGGGGTTAAGTCATTTTCCCA
ATCTATTTATAATTTAATGATATGTTAGTGCCTCTGTTATATGTCAAGTTTAAAGCAGGGCACATTGTTGCAGCAAAATGTGTATTTGAC
AAATTATACTTGCAATTTTGGGTCATGAAAGTTTGCAATATAGTAAATGCACGATTGACTGTTGCTTTGTGCCTCAGTATTTAATTTGTT
TCAGTAAACTTACTTTATTACTGTTTATGATTTCAGATAAAAATAGTTGCTGAGTAAATTTTACTTGTAATCTACAATTGGCTTTTTAAA
AATAACCTGTTGATATATAATTGTCAGTCCAAATGAATATGTGAAACAGCTGGAATTGTACAAATTTTGGTTGTATTTAAAGCTCAGTTT
CCTTTTTGTTTTATTGTATGCGTTGGGTTTGCAGCATGAACTTGCACAGATAATGCACGTTTTCTGGTTAAGTAAACATGATGCACACTA
TTCTGTAACAGAAAGCCCTATTGTGCCTTACCTGTGTGCTTTTGTGGGCACCTTGTTTATGAAGAATAAAAAATGATTTGTTATCTGAAG
AGAATAAATTTTAAATTCTCAGTTTATGTCTCAGATGCTAACGTGTGAAAATATAAATATATATAATATATAAAGTAACCAGTCTTCCTG
TATTTTATGTGCATCATAGTGATTTATCTGAGCTTAGTGACCCCCATCTTGTAACCTGTTGCAAGAGTGAATGTAAAAAATAGTTGTGGC
ATTTTAAAAGGTCGCCTTTGATGCAGATGCATCTTTTTCTTGCTTCTAAAACATATTTCATGTAAACATTGTACATTTATTATTGTAATA
TATACTATTATGCAGCTTATTTTACCTGAAACTGTTAAGCCGACCAAGATCCCTCCCTGCAAGACAGATGGGAATGTGTATAATAACTAG

>54537_54537_1_MOCS1-LEMD3_MOCS1_chr6_39893421_ENST00000373186_LEMD3_chr12_65632281_ENST00000308330_length(amino acids)=348AA_BP=2
MWDLGPEYEGIFNTSLQWILENGKDVGIRCVGFGPEEELTNITDVQFLQSTRPLMSFWCRFRRAFVTVTHRLLLLCLGVVMVCVVLRYMK
YRWTKEEEETRQMYDMVVKIIDVLRSHNEACQENKDLQPYMPIPHVRDSLIQPHDRKKMKKVWDRAVDFLAANESRVRTETRRIGGADFL
VWRWIQPSASCDKILVIPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPVMEIGDQWHLAIQEAILEKCSDNDGIVHIAVDKNSREGC

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>54537_54537_2_MOCS1-LEMD3_MOCS1_chr6_39893422_ENST00000373186_LEMD3_chr12_65632282_ENST00000308330_length(transcript)=3599nt_BP=556nt
GCCAGAAATCTTCCCAGTAGAGATCACCATCCGCCCCCGACCCCCAAGCTGAATACTTAAGGGGTGGGTCCTTCCCATCAAGCTGATTTC
TCAACGAGAGGGACAATCCCAGCTTCCCCAACATTGCAGAGCCCAAACATGTGGAAGAGTTGGAAGCTCCGCACAGATGTCAGAGTAAGG
GAGGGGGCAGGCGGTTCTCCTTGTGCCTCTTCCCAGCCCGGTAGCAGGGGCCCATGCTTCCTCCCTGGTCTGTCCTCGCAGGAGGTGTCC
AGGCGGAGGCAGTTCCTGCGGGAGCATGCGGCCCCCTTCTCCGCCTTCCTCACAGACAGCTTCGGCCGGCAGCACAGCTACCTGCGGATC
TCCCTCACAGAGAAGTGCAACCTCAGATGTCAGTACTGCATGCCCGAGGAGGGGGTCCCGCTGACCCCCAAAGCCAACCTGCTGACCACA
GAGGAGATCCTGACCCTCGCCCGGCTCTTTGTGAAGGAAGGCATCGACAAGATCCGGCTCACAGGTGGAGAGCCGCTTATCCGGCCGGAC
GTGGTGGACATTGTGGGATTTAGGTCCTGAATATGAAGGTATATTTAACACTTCATTGCAGTGGATCTTAGAAAATGGAAAAGATGTTGG
AATAAGGTGTGTTGGTTTTGGCCCTGAGGAAGAATTGACAAATATAACTGATGTGCAGTTTTTACAGTCCACAAGACCACTGATGTCTTT
TTGGTGTCGTTTTCGACGTGCTTTTGTTACTGTAACTCACAGATTATTGTTGTTATGCTTAGGTGTAGTGATGGTTTGTGTCGTTCTGCG
TTACATGAAATATCGATGGACAAAAGAAGAGGAGGAAACAAGGCAGATGTATGATATGGTGGTAAAGATTATAGATGTTTTACGAAGTCA
TAATGAAGCCTGCCAGGAAAACAAAGATTTACAACCTTACATGCCTATTCCACATGTACGCGATTCCTTAATACAGCCTCATGACAGGAA
AAAAATGAAGAAAGTCTGGGATAGAGCTGTTGACTTCCTTGCTGCTAATGAGTCTAGAGTTCGCACGGAAACACGAAGAATAGGTGGTGC
AGATTTTCTGGTTTGGCGGTGGATCCAGCCTTCTGCATCCTGTGACAAAATATTAGTTATACCTTCTAAAGTATGGCAAGGTCAAGCATT
TCATTTAGATAGAAGAAATTCACCACCAAATAGTTTGACACCGTGTCTAAAGATTCGGAATATGTTTGATCCCGTTATGGAAATAGGGGA
TCAGTGGCATTTGGCAATTCAAGAAGCAATTTTAGAAAAATGCAGTGATAATGATGGCATTGTTCACATTGCAGTAGACAAAAATTCACG
TGAGGGTTGTGTATATGTTAAATGTCTGTCTCCAGAATATGCTGGAAAGGCTTTTAAAGCATTGCATGGCTCTTGGTTTGATGGGAAATT
GGTTACAGTAAAATATTTACGACTAGATAGATACCACCATCGCTTTCCCCAGGCTCTCACTTCCAACACTCCATTGAAGCCATCAAATAA
ACATATGAACTCCATGTCTCATCTTCGTCTTCGGACTGGCCTAACCAATTCTCAAGGAAGTTCCTGAAAAGATTTTCTTCCATTTCTAAG
ACTGTTATTTACAATAGGAAAATTCCTGTTTGGCTTTTTGTCTTCCTTTTTAAATGCTTTTTGTATGTAATATTTTTATTGATGAATACA
TCTCTGAACGTTCCAGAAGTCTTAAGGTTCCAAAGGGATTTAGCAGTGAGGCAGCAATGCTGAGTAGGTAGGATAATTATTTCATTCAGT
TTTTGGAGCTCAGTTAAGCCAATACATTTAAAGTTTTGCATGAGGAACACTGACTTTATTAAGCATTTTCAGATGTGGTGGTTGTATTTT
TGCCCCAAGAAGTGTTTGGATAACCACACAAAAGCATGATGAAAAGGCTTCTTGTAGTCCCATAATTTCTTGTGAACTAATGTTGTGAAT
TTTTGTATACAGTCACCTGCATAGTTCCTACAGGCTAATGTGGTAAAACTGTTGATTTCCCAATTTAACCTTAGGTTTCTGTTGCTTATA
AGCGATTCATTTGCTACGGCTGGAATATGGGAAAATTAATTTGGGCTTAGTGGTTACAAATATGTGTAAGTGGATGTATATGTACTTAAA
CTGGCTTTGTATATATGTATAAATGCTGGTGGTGGTGAAAGTAGTCTTGTTTTATGAGGATGTCTGCATTAAAGCAGTAAAATAAGCTTT
CCATTTTATTCATAATCTAATGTGTGTGTATATATGTATGTGTGTATGTGTGTGTATATATAGATGTATATATATACACACACAGAGATA
TATACATATGGCTGTACTTTTGCATAGATCAAACAGCCAAACACCTGGAAGTATTAGATACAAGTTTAAAATATCTTTTATAGGTTTTAT
ATAAAAATGTCTGAGTATGATTTTGTGTGAAAGTTCTGATACCAGTTGTAATAGAGTCAAATTTATGTGAGCAATAAAGAAGAAATTGGC
AGATATTGGAAAAATATTTTGTGAAAAGCTGTATTTATTATAAATACTAGGGCCATGACATAGTACCATTGGGGTTAAGTCATTTTCCCA
ATCTATTTATAATTTAATGATATGTTAGTGCCTCTGTTATATGTCAAGTTTAAAGCAGGGCACATTGTTGCAGCAAAATGTGTATTTGAC
AAATTATACTTGCAATTTTGGGTCATGAAAGTTTGCAATATAGTAAATGCACGATTGACTGTTGCTTTGTGCCTCAGTATTTAATTTGTT
TCAGTAAACTTACTTTATTACTGTTTATGATTTCAGATAAAAATAGTTGCTGAGTAAATTTTACTTGTAATCTACAATTGGCTTTTTAAA
AATAACCTGTTGATATATAATTGTCAGTCCAAATGAATATGTGAAACAGCTGGAATTGTACAAATTTTGGTTGTATTTAAAGCTCAGTTT
CCTTTTTGTTTTATTGTATGCGTTGGGTTTGCAGCATGAACTTGCACAGATAATGCACGTTTTCTGGTTAAGTAAACATGATGCACACTA
TTCTGTAACAGAAAGCCCTATTGTGCCTTACCTGTGTGCTTTTGTGGGCACCTTGTTTATGAAGAATAAAAAATGATTTGTTATCTGAAG
AGAATAAATTTTAAATTCTCAGTTTATGTCTCAGATGCTAACGTGTGAAAATATAAATATATATAATATATAAAGTAACCAGTCTTCCTG
TATTTTATGTGCATCATAGTGATTTATCTGAGCTTAGTGACCCCCATCTTGTAACCTGTTGCAAGAGTGAATGTAAAAAATAGTTGTGGC
ATTTTAAAAGGTCGCCTTTGATGCAGATGCATCTTTTTCTTGCTTCTAAAACATATTTCATGTAAACATTGTACATTTATTATTGTAATA
TATACTATTATGCAGCTTATTTTACCTGAAACTGTTAAGCCGACCAAGATCCCTCCCTGCAAGACAGATGGGAATGTGTATAATAACTAG

>54537_54537_2_MOCS1-LEMD3_MOCS1_chr6_39893422_ENST00000373186_LEMD3_chr12_65632282_ENST00000308330_length(amino acids)=348AA_BP=2
MWDLGPEYEGIFNTSLQWILENGKDVGIRCVGFGPEEELTNITDVQFLQSTRPLMSFWCRFRRAFVTVTHRLLLLCLGVVMVCVVLRYMK
YRWTKEEEETRQMYDMVVKIIDVLRSHNEACQENKDLQPYMPIPHVRDSLIQPHDRKKMKKVWDRAVDFLAANESRVRTETRRIGGADFL
VWRWIQPSASCDKILVIPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPVMEIGDQWHLAIQEAILEKCSDNDGIVHIAVDKNSREGC

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Fusion Gene PPI Analysis for MOCS1-LEMD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneLEMD3chr6:39893421chr12:65632281ENST00000308330313699_911565.0912.0SMAD1%2C SMAD2%2C SMAD3 and SMAD5
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330313699_911565.0912.0SMAD1%2C SMAD2%2C SMAD3 and SMAD5


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MOCS1-LEMD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MOCS1-LEMD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource