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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MOK-ANKRD66 (FusionGDB2 ID:54549)

Fusion Gene Summary for MOK-ANKRD66

Fusion gene summary

Fusion gene information	Fusion gene name: MOK-ANKRD66
	Fusion gene ID: 54549
		Hgene	Tgene
	Gene symbol	MOK	ANKRD66
	Gene ID	5891	100287718
	Gene name	MOK protein kinase	ankyrin repeat domain 66
	Synonyms	RAGE\|RAGE-1\|RAGE1\|STK30	-
	Cytomap	14q32.31	6p12.3
	Type of gene	protein-coding	protein-coding
	Description	MAPK/MAK/MRK overlapping kinaserenal cell carcinoma antigenrenal tumor antigen 1	ankyrin repeat domain-containing protein 66
	Modification date	20200320	20200313
	UniProtAcc	Q9UQ07	.
	Ensembl transtripts involved in fusion gene	ENST00000193029, ENST00000361847, ENST00000522874, ENST00000524214, ENST00000517966, ENST00000519058, ENST00000520266, ENST00000522534, ENST00000522867, ENST00000523231, ENST00000524370, ENST00000561150,	ENST00000536046, ENST00000565422,
Fusion gene scores	* DoF score	11 X 9 X 6=594	1 X 1 X 1=1
	# samples	12	1
	** MAII score	log2(12/594*10)=-2.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: MOK [Title/Abstract] AND ANKRD66 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MOK(102771299)-ANKRD66(46719674), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MOK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ANKRD66 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A8-A07C-01A	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+

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Fusion Gene ORF analysis for MOK-ANKRD66

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000193029	ENST00000536046	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
5UTR-3CDS	ENST00000193029	ENST00000565422	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
In-frame	ENST00000361847	ENST00000536046	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
In-frame	ENST00000361847	ENST00000565422	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
In-frame	ENST00000522874	ENST00000536046	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
In-frame	ENST00000522874	ENST00000565422	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
In-frame	ENST00000524214	ENST00000536046	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
In-frame	ENST00000524214	ENST00000565422	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
intron-3CDS	ENST00000517966	ENST00000536046	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
intron-3CDS	ENST00000517966	ENST00000565422	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
intron-3CDS	ENST00000519058	ENST00000536046	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
intron-3CDS	ENST00000519058	ENST00000565422	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
intron-3CDS	ENST00000520266	ENST00000536046	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
intron-3CDS	ENST00000520266	ENST00000565422	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
intron-3CDS	ENST00000522534	ENST00000536046	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
intron-3CDS	ENST00000522534	ENST00000565422	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
intron-3CDS	ENST00000522867	ENST00000536046	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
intron-3CDS	ENST00000522867	ENST00000565422	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
intron-3CDS	ENST00000523231	ENST00000536046	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
intron-3CDS	ENST00000523231	ENST00000565422	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
intron-3CDS	ENST00000524370	ENST00000536046	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
intron-3CDS	ENST00000524370	ENST00000565422	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
intron-3CDS	ENST00000561150	ENST00000536046	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+
intron-3CDS	ENST00000561150	ENST00000565422	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000522874	MOK	chr14	102771299	-	ENST00000565422	ANKRD66	chr6	46719674	+	1378	190	190	792	200
ENST00000522874	MOK	chr14	102771299	-	ENST00000536046	ANKRD66	chr6	46719674	+	1077	190	190	792	200
ENST00000361847	MOK	chr14	102771299	-	ENST00000565422	ANKRD66	chr6	46719674	+	1427	239	239	841	200
ENST00000361847	MOK	chr14	102771299	-	ENST00000536046	ANKRD66	chr6	46719674	+	1126	239	239	841	200
ENST00000524214	MOK	chr14	102771299	-	ENST00000565422	ANKRD66	chr6	46719674	+	1412	224	224	826	200
ENST00000524214	MOK	chr14	102771299	-	ENST00000536046	ANKRD66	chr6	46719674	+	1111	224	224	826	200

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000522874	ENST00000565422	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+	0.002562509	0.9974375
ENST00000522874	ENST00000536046	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+	0.003684835	0.9963152
ENST00000361847	ENST00000565422	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+	0.003177201	0.99682283
ENST00000361847	ENST00000536046	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+	0.004159883	0.9958402
ENST00000524214	ENST00000565422	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+	0.002854684	0.99714535
ENST00000524214	ENST00000536046	MOK	chr14	102771299	-	ANKRD66	chr6	46719674	+	0.003821019	0.996179

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Fusion Genomic Features for MOK-ANKRD66

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MOK-ANKRD66

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:102771299/chr6:46719674)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MOK Q9UQ07	.
FUNCTION: Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. {ECO:0000250\|UniProtKB:Q9WVS4}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ANKRD66

chr14:102771299

chr6:46719674

ENST00000536046

131_160

223.0

Repeat

Note=ANK 3

Tgene

ANKRD66

chr14:102771299

chr6:46719674

ENST00000536046

62_92

223.0

Repeat

Note=ANK 1

Tgene

ANKRD66

chr14:102771299

chr6:46719674

ENST00000536046

98_127

223.0

Repeat

Note=ANK 2

Tgene

ANKRD66

chr14:102771299

chr6:46719674

ENST00000565422

131_160

252.0

Repeat

Note=ANK 3

Tgene

ANKRD66

chr14:102771299

chr6:46719674

ENST00000565422

62_92

252.0

Repeat

Note=ANK 1

Tgene

ANKRD66

chr14:102771299

chr6:46719674

ENST00000565422

98_127

252.0

Repeat

Note=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MOK

chr14:102771299

chr6:46719674

ENST00000193029

4_285

96.0

Domain

Protein kinase

Hgene

MOK

chr14:102771299

chr6:46719674

ENST00000361847

4_285

420.0

Domain

Protein kinase

Hgene

MOK

chr14:102771299

chr6:46719674

ENST00000193029

10_18

96.0

Nucleotide binding

ATP

Hgene

MOK

chr14:102771299

chr6:46719674

ENST00000361847

10_18

420.0

Nucleotide binding

ATP

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Fusion Gene Sequence for MOK-ANKRD66

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>54549_54549_1_MOK-ANKRD66_MOK_chr14_102771299_ENST00000361847_ANKRD66_chr6_46719674_ENST00000536046_length(transcript)=1126nt_BP=239nt
ATCTTGCGCATGCGCAGGCGACAGCTCATGGCGTTCAGGGCCTGACGGTTGCTAGGGTGACAGGGACACAACATGGCGGCGGGATCTCTA
ACGCTCTCCTTCGAGGGACCACCACGGAGATCCTAGTGCGGGACCCCGCCTCAGGGAAGTGGAAAGCAGGGGGACAACCTTCCTGCTTCT
TTCTTTTCCGTCCAGTGTCGGCAAGGGGTTGTCACCGGCTTCCGCATCCAAGATGAAGATTGTTTTCTGCCATGGAATTGGCCAAAATGT
CAGACATGACAAAGCTTCACCAAGCTGTGGCTGCAGGAGACTACAGCTTAGTGAAGAAGATTTTGAAGAAAGGTCTCTGTGACCCAAACT
ACAAAGATGTAGACTGGAATGACCGGACCCCACTTCACTGGGCTGCAATCAAAGGGCAAATGGAGGTGATACGGCTCCTGATAGAATATG
GAGCCAGGCCCTGCCTGGTTACTAGTGTGGGCTGGACCCCAGCTCATTTTGCAGCAGAAGCAGGCCATCTGAATATACTCAAAACTCTCC
ATGCATTGCACGCTGCCATCGACGCCCCTGACTTCTTTGGAGACACACCGAAGAGGATTGCACAGATCTATGGACAGAAAGCCTGTGTGG
CATTTCTGGAAAAGGCAGAGCCCGAGTGCCAGGACCACCGTTGCGCTGCCCAGCAGAAGGGGCTGCCTCTGGATGAGCGTGATGAAGACT
GGGATGCCAAGAAAAGGGAGCTGGAGCTGTCTCTTCCTTCCCTAAATCAAAACATGAATAAAAAGAATAAGAAAAGTCGAGGCCCCACCA
GGCCCAGCAATACCAAGGGGAGGAGAGTATGAGAACTCAACCTTATGTTTTCTGGCAAGGAACTTTCCCTGGTGCCAGAAATGAGGCTGT
TAGGCATGGTGGCCTTTCCATGACTTTACTCATAGACCCTTACCCACCTGGCTTCTGCCCATGGACCTGTCATTAGGTGCTGTCCACATG
GGCTGTTGTTTCCTGGCTAGCACCTACTGTGTACAATAATTACCGGGAAAGGACAAAACCTGCTTGCATTTTGTCATCAGTGGTTTGCAC

>54549_54549_1_MOK-ANKRD66_MOK_chr14_102771299_ENST00000361847_ANKRD66_chr6_46719674_ENST00000536046_length(amino acids)=200AA_BP=1
MFSAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAE
AGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQKGLPLDERDEDWDAKKRELELSLPSLNQNMN

--------------------------------------------------------------
>54549_54549_2_MOK-ANKRD66_MOK_chr14_102771299_ENST00000361847_ANKRD66_chr6_46719674_ENST00000565422_length(transcript)=1427nt_BP=239nt
ATCTTGCGCATGCGCAGGCGACAGCTCATGGCGTTCAGGGCCTGACGGTTGCTAGGGTGACAGGGACACAACATGGCGGCGGGATCTCTA
ACGCTCTCCTTCGAGGGACCACCACGGAGATCCTAGTGCGGGACCCCGCCTCAGGGAAGTGGAAAGCAGGGGGACAACCTTCCTGCTTCT
TTCTTTTCCGTCCAGTGTCGGCAAGGGGTTGTCACCGGCTTCCGCATCCAAGATGAAGATTGTTTTCTGCCATGGAATTGGCCAAAATGT
CAGACATGACAAAGCTTCACCAAGCTGTGGCTGCAGGAGACTACAGCTTAGTGAAGAAGATTTTGAAGAAAGGTCTCTGTGACCCAAACT
ACAAAGATGTAGACTGGAATGACCGGACCCCACTTCACTGGGCTGCAATCAAAGGGCAAATGGAGGTGATACGGCTCCTGATAGAATATG
GAGCCAGGCCCTGCCTGGTTACTAGTGTGGGCTGGACCCCAGCTCATTTTGCAGCAGAAGCAGGCCATCTGAATATACTCAAAACTCTCC
ATGCATTGCACGCTGCCATCGACGCCCCTGACTTCTTTGGAGACACACCGAAGAGGATTGCACAGATCTATGGACAGAAAGCCTGTGTGG
CATTTCTGGAAAAGGCAGAGCCCGAGTGCCAGGACCACCGTTGCGCTGCCCAGCAGAAGGGGCTGCCTCTGGATGAGCGTGATGAAGACT
GGGATGCCAAGAAAAGGGAGCTGGAGCTGTCTCTTCCTTCCCTAAATCAAAACATGAATAAAAAGAATAAGAAAAGTCGAGGCCCCACCA
GGCCCAGCAATACCAAGGGGAGGAGAGTATGAGAACTCAACCTTATGTTTTCTGGCAAGGAACTTTCCCTGGTGCCAGAAATGAGGCTGT
TAGGCATGGTGGCCTTTCCATGACTTTACTCATAGACCCTTACCCACCTGGCTTCTGCCCATGGACCTGTCATTAGGTGCTGTCCACATG
GGCTGTTGTTTCCTGGCTAGCACCTACTGTGTACAATAATTACCGGGAAAGGACAAAACCTGCTTGCATTTTGTCATCAGTGGTTTGCAC
AGTCAGCATCTTTTGACCCCTGCCCCCCAACAATAATAGAATTTCAGGAGACAAGGAAACTCTGGCATGAATTAACTTCATCCCTGATAA
CGATCGAGAGATAATGTAAAATAATGAACATGTGATTATAGGTCTACTTTTTCAACTGTAAATTTGGGAAAATTAAATTCAGATCAGATA
ATTCCAATAAAAAATTGCATCCAAATTGAGATGCAAAATACACATTAGATTTCAAACACTTAGTACAAAAATATAAAATGTCTCCTTAAT

>54549_54549_2_MOK-ANKRD66_MOK_chr14_102771299_ENST00000361847_ANKRD66_chr6_46719674_ENST00000565422_length(amino acids)=200AA_BP=1
MFSAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAE
AGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQKGLPLDERDEDWDAKKRELELSLPSLNQNMN

--------------------------------------------------------------
>54549_54549_3_MOK-ANKRD66_MOK_chr14_102771299_ENST00000522874_ANKRD66_chr6_46719674_ENST00000536046_length(transcript)=1077nt_BP=190nt
TGCTAGGGTGACAGGGACACAACATGGCGGCGGGATCTCTAACGCTCTCCTTCGAGGGACCACCACGGAGATCCTAGTGCGGGACCCCGC
CTCAGGGAAGTGGAAAGCAGGGGGACAACCTTCCTGCTTCTTTCTTTTCCGTCCAGTGTCGGCAAGGGGTTGTCACCGGCTTCCGCATCC
AAGATGAAGATTGTTTTCTGCCATGGAATTGGCCAAAATGTCAGACATGACAAAGCTTCACCAAGCTGTGGCTGCAGGAGACTACAGCTT
AGTGAAGAAGATTTTGAAGAAAGGTCTCTGTGACCCAAACTACAAAGATGTAGACTGGAATGACCGGACCCCACTTCACTGGGCTGCAAT
CAAAGGGCAAATGGAGGTGATACGGCTCCTGATAGAATATGGAGCCAGGCCCTGCCTGGTTACTAGTGTGGGCTGGACCCCAGCTCATTT
TGCAGCAGAAGCAGGCCATCTGAATATACTCAAAACTCTCCATGCATTGCACGCTGCCATCGACGCCCCTGACTTCTTTGGAGACACACC
GAAGAGGATTGCACAGATCTATGGACAGAAAGCCTGTGTGGCATTTCTGGAAAAGGCAGAGCCCGAGTGCCAGGACCACCGTTGCGCTGC
CCAGCAGAAGGGGCTGCCTCTGGATGAGCGTGATGAAGACTGGGATGCCAAGAAAAGGGAGCTGGAGCTGTCTCTTCCTTCCCTAAATCA
AAACATGAATAAAAAGAATAAGAAAAGTCGAGGCCCCACCAGGCCCAGCAATACCAAGGGGAGGAGAGTATGAGAACTCAACCTTATGTT
TTCTGGCAAGGAACTTTCCCTGGTGCCAGAAATGAGGCTGTTAGGCATGGTGGCCTTTCCATGACTTTACTCATAGACCCTTACCCACCT
GGCTTCTGCCCATGGACCTGTCATTAGGTGCTGTCCACATGGGCTGTTGTTTCCTGGCTAGCACCTACTGTGTACAATAATTACCGGGAA

>54549_54549_3_MOK-ANKRD66_MOK_chr14_102771299_ENST00000522874_ANKRD66_chr6_46719674_ENST00000536046_length(amino acids)=200AA_BP=1
MFSAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAE
AGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQKGLPLDERDEDWDAKKRELELSLPSLNQNMN

--------------------------------------------------------------
>54549_54549_4_MOK-ANKRD66_MOK_chr14_102771299_ENST00000522874_ANKRD66_chr6_46719674_ENST00000565422_length(transcript)=1378nt_BP=190nt
TGCTAGGGTGACAGGGACACAACATGGCGGCGGGATCTCTAACGCTCTCCTTCGAGGGACCACCACGGAGATCCTAGTGCGGGACCCCGC
CTCAGGGAAGTGGAAAGCAGGGGGACAACCTTCCTGCTTCTTTCTTTTCCGTCCAGTGTCGGCAAGGGGTTGTCACCGGCTTCCGCATCC
AAGATGAAGATTGTTTTCTGCCATGGAATTGGCCAAAATGTCAGACATGACAAAGCTTCACCAAGCTGTGGCTGCAGGAGACTACAGCTT
AGTGAAGAAGATTTTGAAGAAAGGTCTCTGTGACCCAAACTACAAAGATGTAGACTGGAATGACCGGACCCCACTTCACTGGGCTGCAAT
CAAAGGGCAAATGGAGGTGATACGGCTCCTGATAGAATATGGAGCCAGGCCCTGCCTGGTTACTAGTGTGGGCTGGACCCCAGCTCATTT
TGCAGCAGAAGCAGGCCATCTGAATATACTCAAAACTCTCCATGCATTGCACGCTGCCATCGACGCCCCTGACTTCTTTGGAGACACACC
GAAGAGGATTGCACAGATCTATGGACAGAAAGCCTGTGTGGCATTTCTGGAAAAGGCAGAGCCCGAGTGCCAGGACCACCGTTGCGCTGC
CCAGCAGAAGGGGCTGCCTCTGGATGAGCGTGATGAAGACTGGGATGCCAAGAAAAGGGAGCTGGAGCTGTCTCTTCCTTCCCTAAATCA
AAACATGAATAAAAAGAATAAGAAAAGTCGAGGCCCCACCAGGCCCAGCAATACCAAGGGGAGGAGAGTATGAGAACTCAACCTTATGTT
TTCTGGCAAGGAACTTTCCCTGGTGCCAGAAATGAGGCTGTTAGGCATGGTGGCCTTTCCATGACTTTACTCATAGACCCTTACCCACCT
GGCTTCTGCCCATGGACCTGTCATTAGGTGCTGTCCACATGGGCTGTTGTTTCCTGGCTAGCACCTACTGTGTACAATAATTACCGGGAA
AGGACAAAACCTGCTTGCATTTTGTCATCAGTGGTTTGCACAGTCAGCATCTTTTGACCCCTGCCCCCCAACAATAATAGAATTTCAGGA
GACAAGGAAACTCTGGCATGAATTAACTTCATCCCTGATAACGATCGAGAGATAATGTAAAATAATGAACATGTGATTATAGGTCTACTT
TTTCAACTGTAAATTTGGGAAAATTAAATTCAGATCAGATAATTCCAATAAAAAATTGCATCCAAATTGAGATGCAAAATACACATTAGA
TTTCAAACACTTAGTACAAAAATATAAAATGTCTCCTTAATAATACTTAATATTGATTCCACATTGAAATGATAATATTTTGGATATTGC

>54549_54549_4_MOK-ANKRD66_MOK_chr14_102771299_ENST00000522874_ANKRD66_chr6_46719674_ENST00000565422_length(amino acids)=200AA_BP=1
MFSAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAE
AGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQKGLPLDERDEDWDAKKRELELSLPSLNQNMN

--------------------------------------------------------------
>54549_54549_5_MOK-ANKRD66_MOK_chr14_102771299_ENST00000524214_ANKRD66_chr6_46719674_ENST00000536046_length(transcript)=1111nt_BP=224nt
AGGCGACAGCTCATGGCGTTCAGGGCCTGACGGTTGCTAGGGTGACAGGGACACAACATGGCGGCGGGATCTCTAACGCTCTCCTTCGAG
GGACCACCACGGAGATCCTAGTGCGGGACCCCGCCTCAGGGAAGTGGAAAGCAGGGGGACAACCTTCCTGCTTCTTTCTTTTCCGTCCAG
TGTCGGCAAGGGGTTGTCACCGGCTTCCGCATCCAAGATGAAGATTGTTTTCTGCCATGGAATTGGCCAAAATGTCAGACATGACAAAGC
TTCACCAAGCTGTGGCTGCAGGAGACTACAGCTTAGTGAAGAAGATTTTGAAGAAAGGTCTCTGTGACCCAAACTACAAAGATGTAGACT
GGAATGACCGGACCCCACTTCACTGGGCTGCAATCAAAGGGCAAATGGAGGTGATACGGCTCCTGATAGAATATGGAGCCAGGCCCTGCC
TGGTTACTAGTGTGGGCTGGACCCCAGCTCATTTTGCAGCAGAAGCAGGCCATCTGAATATACTCAAAACTCTCCATGCATTGCACGCTG
CCATCGACGCCCCTGACTTCTTTGGAGACACACCGAAGAGGATTGCACAGATCTATGGACAGAAAGCCTGTGTGGCATTTCTGGAAAAGG
CAGAGCCCGAGTGCCAGGACCACCGTTGCGCTGCCCAGCAGAAGGGGCTGCCTCTGGATGAGCGTGATGAAGACTGGGATGCCAAGAAAA
GGGAGCTGGAGCTGTCTCTTCCTTCCCTAAATCAAAACATGAATAAAAAGAATAAGAAAAGTCGAGGCCCCACCAGGCCCAGCAATACCA
AGGGGAGGAGAGTATGAGAACTCAACCTTATGTTTTCTGGCAAGGAACTTTCCCTGGTGCCAGAAATGAGGCTGTTAGGCATGGTGGCCT
TTCCATGACTTTACTCATAGACCCTTACCCACCTGGCTTCTGCCCATGGACCTGTCATTAGGTGCTGTCCACATGGGCTGTTGTTTCCTG
GCTAGCACCTACTGTGTACAATAATTACCGGGAAAGGACAAAACCTGCTTGCATTTTGTCATCAGTGGTTTGCACAGTCAGCATCTTTTG

>54549_54549_5_MOK-ANKRD66_MOK_chr14_102771299_ENST00000524214_ANKRD66_chr6_46719674_ENST00000536046_length(amino acids)=200AA_BP=1
MFSAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAE
AGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQKGLPLDERDEDWDAKKRELELSLPSLNQNMN

--------------------------------------------------------------
>54549_54549_6_MOK-ANKRD66_MOK_chr14_102771299_ENST00000524214_ANKRD66_chr6_46719674_ENST00000565422_length(transcript)=1412nt_BP=224nt
AGGCGACAGCTCATGGCGTTCAGGGCCTGACGGTTGCTAGGGTGACAGGGACACAACATGGCGGCGGGATCTCTAACGCTCTCCTTCGAG
GGACCACCACGGAGATCCTAGTGCGGGACCCCGCCTCAGGGAAGTGGAAAGCAGGGGGACAACCTTCCTGCTTCTTTCTTTTCCGTCCAG
TGTCGGCAAGGGGTTGTCACCGGCTTCCGCATCCAAGATGAAGATTGTTTTCTGCCATGGAATTGGCCAAAATGTCAGACATGACAAAGC
TTCACCAAGCTGTGGCTGCAGGAGACTACAGCTTAGTGAAGAAGATTTTGAAGAAAGGTCTCTGTGACCCAAACTACAAAGATGTAGACT
GGAATGACCGGACCCCACTTCACTGGGCTGCAATCAAAGGGCAAATGGAGGTGATACGGCTCCTGATAGAATATGGAGCCAGGCCCTGCC
TGGTTACTAGTGTGGGCTGGACCCCAGCTCATTTTGCAGCAGAAGCAGGCCATCTGAATATACTCAAAACTCTCCATGCATTGCACGCTG
CCATCGACGCCCCTGACTTCTTTGGAGACACACCGAAGAGGATTGCACAGATCTATGGACAGAAAGCCTGTGTGGCATTTCTGGAAAAGG
CAGAGCCCGAGTGCCAGGACCACCGTTGCGCTGCCCAGCAGAAGGGGCTGCCTCTGGATGAGCGTGATGAAGACTGGGATGCCAAGAAAA
GGGAGCTGGAGCTGTCTCTTCCTTCCCTAAATCAAAACATGAATAAAAAGAATAAGAAAAGTCGAGGCCCCACCAGGCCCAGCAATACCA
AGGGGAGGAGAGTATGAGAACTCAACCTTATGTTTTCTGGCAAGGAACTTTCCCTGGTGCCAGAAATGAGGCTGTTAGGCATGGTGGCCT
TTCCATGACTTTACTCATAGACCCTTACCCACCTGGCTTCTGCCCATGGACCTGTCATTAGGTGCTGTCCACATGGGCTGTTGTTTCCTG
GCTAGCACCTACTGTGTACAATAATTACCGGGAAAGGACAAAACCTGCTTGCATTTTGTCATCAGTGGTTTGCACAGTCAGCATCTTTTG
ACCCCTGCCCCCCAACAATAATAGAATTTCAGGAGACAAGGAAACTCTGGCATGAATTAACTTCATCCCTGATAACGATCGAGAGATAAT
GTAAAATAATGAACATGTGATTATAGGTCTACTTTTTCAACTGTAAATTTGGGAAAATTAAATTCAGATCAGATAATTCCAATAAAAAAT
TGCATCCAAATTGAGATGCAAAATACACATTAGATTTCAAACACTTAGTACAAAAATATAAAATGTCTCCTTAATAATACTTAATATTGA

>54549_54549_6_MOK-ANKRD66_MOK_chr14_102771299_ENST00000524214_ANKRD66_chr6_46719674_ENST00000565422_length(amino acids)=200AA_BP=1
MFSAMELAKMSDMTKLHQAVAAGDYSLVKKILKKGLCDPNYKDVDWNDRTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAE
AGHLNILKTLHALHAAIDAPDFFGDTPKRIAQIYGQKACVAFLEKAEPECQDHRCAAQQKGLPLDERDEDWDAKKRELELSLPSLNQNMN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MOK-ANKRD66

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MOK-ANKRD66

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MOK-ANKRD66

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source