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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MOK-HSP90AA1 (FusionGDB2 ID:54554)

Fusion Gene Summary for MOK-HSP90AA1

Fusion gene summary

Fusion gene information	Fusion gene name: MOK-HSP90AA1
	Fusion gene ID: 54554
		Hgene	Tgene
	Gene symbol	MOK	HSP90AA1
	Gene ID	5891	3320
	Gene name	MOK protein kinase	heat shock protein 90 alpha family class A member 1
	Synonyms	RAGE\|RAGE-1\|RAGE1\|STK30	EL52\|HEL-S-65p\|HSP86\|HSP89A\|HSP90A\|HSP90N\|HSPC1\|HSPCA\|HSPCAL1\|HSPCAL4\|HSPN\|Hsp103\|Hsp89\|Hsp90\|LAP-2\|LAP2
	Cytomap	14q32.31	14q32.31
	Type of gene	protein-coding	protein-coding
	Description	MAPK/MAK/MRK overlapping kinaserenal cell carcinoma antigenrenal tumor antigen 1	heat shock protein HSP 90-alphaHSP 86LPS-associated protein 2epididymis luminal secretory protein 52epididymis secretory sperm binding protein Li 65pheat shock 86 kDaheat shock 90kD protein 1, alphaheat shock 90kD protein 1, alpha-like 4heat shock
	Modification date	20200320	20200327
	UniProtAcc	Q9UQ07	P07900
	Ensembl transtripts involved in fusion gene	ENST00000361847, ENST00000522874, ENST00000524214, ENST00000193029, ENST00000517966, ENST00000519058, ENST00000520266, ENST00000522534, ENST00000522867, ENST00000523231, ENST00000524370, ENST00000561150,	ENST00000558600, ENST00000216281, ENST00000334701, ENST00000441629,
Fusion gene scores	* DoF score	11 X 9 X 6=594	30 X 32 X 8=7680
	# samples	12	42
	** MAII score	log2(12/594*10)=-2.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(42/7680*10)=-4.1926450779424 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MOK [Title/Abstract] AND HSP90AA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HSP90AA1(102605587)-MOK(102718332), # samples:1 MOK(102749815)-HSP90AA1(102568419), # samples:1 MOK(102729883)-HSP90AA1(102568422), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	HSP90AA1	GO:0001934	positive regulation of protein phosphorylation	19363271
Tgene	HSP90AA1	GO:0007004	telomere maintenance via telomerase	10197982
Tgene	HSP90AA1	GO:0031396	regulation of protein ubiquitination	16809764
Tgene	HSP90AA1	GO:0032273	positive regulation of protein polymerization	19363271
Tgene	HSP90AA1	GO:0045040	protein import into mitochondrial outer membrane	15644312
Tgene	HSP90AA1	GO:0051131	chaperone-mediated protein complex assembly	15644312
Tgene	HSP90AA1	GO:0051973	positive regulation of telomerase activity	10197982
Tgene	HSP90AA1	GO:1902949	positive regulation of tau-protein kinase activity	19363271
Tgene	HSP90AA1	GO:1905323	telomerase holoenzyme complex assembly	10197982

Fusion gene breakpoints across MOK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HSP90AA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-UY-A78K-01A	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
ChimerDB4	BRCA	TCGA-A7-A6VV-01A	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-

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Fusion Gene ORF analysis for MOK-HSP90AA1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000361847	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-5UTR	ENST00000361847	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-5UTR	ENST00000522874	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-5UTR	ENST00000522874	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-5UTR	ENST00000524214	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-5UTR	ENST00000524214	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000361847	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000361847	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000361847	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000361847	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000361847	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000361847	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000522874	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000522874	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000522874	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000522874	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000522874	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000522874	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000524214	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000524214	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000524214	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000524214	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000524214	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000524214	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5UTR-5UTR	ENST00000193029	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5UTR-5UTR	ENST00000193029	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5UTR-intron	ENST00000193029	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5UTR-intron	ENST00000193029	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5UTR-intron	ENST00000193029	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5UTR-intron	ENST00000193029	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5UTR-intron	ENST00000193029	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5UTR-intron	ENST00000193029	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-5UTR	ENST00000517966	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-5UTR	ENST00000517966	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-5UTR	ENST00000519058	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-5UTR	ENST00000519058	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-5UTR	ENST00000520266	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-5UTR	ENST00000520266	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-5UTR	ENST00000522534	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-5UTR	ENST00000522534	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-5UTR	ENST00000522867	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-5UTR	ENST00000522867	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-5UTR	ENST00000523231	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-5UTR	ENST00000523231	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-5UTR	ENST00000524370	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-5UTR	ENST00000524370	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-5UTR	ENST00000561150	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-5UTR	ENST00000561150	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000517966	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000517966	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000517966	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000517966	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000517966	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000517966	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000519058	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000519058	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000519058	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000519058	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000519058	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000519058	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000520266	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000520266	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000520266	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000520266	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000520266	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000520266	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000522534	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000522534	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000522534	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000522534	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000522534	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000522534	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000522867	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000522867	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000522867	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000522867	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000522867	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000522867	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000523231	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000523231	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000523231	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000523231	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000523231	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000523231	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000524370	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000524370	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000524370	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000524370	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000524370	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000524370	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000561150	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000561150	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000561150	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000561150	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000561150	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000561150	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for MOK-HSP90AA1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MOK-HSP90AA1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:102605587/:102718332)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MOK Q9UQ07	HSP90AA1 P07900
FUNCTION: Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. {ECO:0000250\|UniProtKB:Q9WVS4}.	FUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155, PubMed:12526792). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues(PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochodria outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269\|PubMed:11274138, ECO:0000269\|PubMed:11276205, ECO:0000269\|PubMed:12526792, ECO:0000269\|PubMed:15577939, ECO:0000269\|PubMed:15937123, ECO:0000269\|PubMed:20628368, ECO:0000269\|PubMed:24613385, ECO:0000269\|PubMed:25609812, ECO:0000269\|PubMed:27353360, ECO:0000269\|PubMed:29127155, ECO:0000303\|PubMed:25973397, ECO:0000303\|PubMed:26991466, ECO:0000303\|PubMed:27295069}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for MOK-HSP90AA1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MOK-HSP90AA1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MOK-HSP90AA1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MOK-HSP90AA1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source