Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MOK-MOK (FusionGDB2 ID:54558)

Fusion Gene Summary for MOK-MOK

Fusion gene summary

Fusion gene information	Fusion gene name: MOK-MOK
	Fusion gene ID: 54558
		Hgene	Tgene
	Gene symbol	MOK	MOK
	Gene ID	5891	5891
	Gene name	MOK protein kinase	MOK protein kinase
	Synonyms	RAGE\|RAGE-1\|RAGE1\|STK30	RAGE\|RAGE-1\|RAGE1\|STK30
	Cytomap	14q32.31	14q32.31
	Type of gene	protein-coding	protein-coding
	Description	MAPK/MAK/MRK overlapping kinaserenal cell carcinoma antigenrenal tumor antigen 1	MAPK/MAK/MRK overlapping kinaserenal cell carcinoma antigenrenal tumor antigen 1
	Modification date	20200320	20200320
	UniProtAcc	Q9UQ07	Q9UQ07
	Ensembl transtripts involved in fusion gene	ENST00000193029, ENST00000361847, ENST00000517966, ENST00000519058, ENST00000520266, ENST00000522534, ENST00000522867, ENST00000522874, ENST00000523231, ENST00000524214, ENST00000524370, ENST00000561150,	ENST00000522867, ENST00000193029, ENST00000361847, ENST00000517966, ENST00000519058, ENST00000520266, ENST00000522534, ENST00000522874, ENST00000523231, ENST00000524214, ENST00000524370, ENST00000561150,
Fusion gene scores	* DoF score	11 X 9 X 6=594	8 X 8 X 2=128
	# samples	12	8
	** MAII score	log2(12/594*10)=-2.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/128*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MOK [Title/Abstract] AND MOK [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MOK(102698940)-MOK(102699273), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MOK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MOK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AA452570	MOK	chr14	102698940	-	MOK	chr14	102699273	-

Top

Fusion Gene ORF analysis for MOK-MOK

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-5UTR	ENST00000193029	ENST00000522867	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-5UTR	ENST00000361847	ENST00000522867	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-5UTR	ENST00000517966	ENST00000522867	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-5UTR	ENST00000519058	ENST00000522867	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-5UTR	ENST00000520266	ENST00000522867	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-5UTR	ENST00000522534	ENST00000522867	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-5UTR	ENST00000522867	ENST00000522867	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-5UTR	ENST00000522874	ENST00000522867	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-5UTR	ENST00000523231	ENST00000522867	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-5UTR	ENST00000524214	ENST00000522867	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-5UTR	ENST00000524370	ENST00000522867	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-5UTR	ENST00000561150	ENST00000522867	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000193029	ENST00000193029	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000193029	ENST00000361847	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000193029	ENST00000517966	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000193029	ENST00000519058	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000193029	ENST00000520266	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000193029	ENST00000522534	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000193029	ENST00000522874	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000193029	ENST00000523231	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000193029	ENST00000524214	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000193029	ENST00000524370	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000193029	ENST00000561150	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000361847	ENST00000193029	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000361847	ENST00000361847	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000361847	ENST00000517966	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000361847	ENST00000519058	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000361847	ENST00000520266	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000361847	ENST00000522534	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000361847	ENST00000522874	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000361847	ENST00000523231	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000361847	ENST00000524214	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000361847	ENST00000524370	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000361847	ENST00000561150	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000517966	ENST00000193029	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000517966	ENST00000361847	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000517966	ENST00000517966	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000517966	ENST00000519058	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000517966	ENST00000520266	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000517966	ENST00000522534	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000517966	ENST00000522874	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000517966	ENST00000523231	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000517966	ENST00000524214	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000517966	ENST00000524370	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000517966	ENST00000561150	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000519058	ENST00000193029	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000519058	ENST00000361847	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000519058	ENST00000517966	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000519058	ENST00000519058	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000519058	ENST00000520266	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000519058	ENST00000522534	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000519058	ENST00000522874	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000519058	ENST00000523231	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000519058	ENST00000524214	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000519058	ENST00000524370	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000519058	ENST00000561150	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000520266	ENST00000193029	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000520266	ENST00000361847	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000520266	ENST00000517966	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000520266	ENST00000519058	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000520266	ENST00000520266	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000520266	ENST00000522534	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000520266	ENST00000522874	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000520266	ENST00000523231	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000520266	ENST00000524214	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000520266	ENST00000524370	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000520266	ENST00000561150	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522534	ENST00000193029	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522534	ENST00000361847	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522534	ENST00000517966	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522534	ENST00000519058	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522534	ENST00000520266	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522534	ENST00000522534	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522534	ENST00000522874	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522534	ENST00000523231	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522534	ENST00000524214	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522534	ENST00000524370	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522534	ENST00000561150	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522867	ENST00000193029	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522867	ENST00000361847	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522867	ENST00000517966	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522867	ENST00000519058	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522867	ENST00000520266	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522867	ENST00000522534	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522867	ENST00000522874	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522867	ENST00000523231	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522867	ENST00000524214	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522867	ENST00000524370	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522867	ENST00000561150	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522874	ENST00000193029	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522874	ENST00000361847	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522874	ENST00000517966	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522874	ENST00000519058	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522874	ENST00000520266	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522874	ENST00000522534	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522874	ENST00000522874	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522874	ENST00000523231	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522874	ENST00000524214	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522874	ENST00000524370	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000522874	ENST00000561150	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000523231	ENST00000193029	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000523231	ENST00000361847	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000523231	ENST00000517966	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000523231	ENST00000519058	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000523231	ENST00000520266	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000523231	ENST00000522534	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000523231	ENST00000522874	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000523231	ENST00000523231	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000523231	ENST00000524214	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000523231	ENST00000524370	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000523231	ENST00000561150	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524214	ENST00000193029	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524214	ENST00000361847	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524214	ENST00000517966	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524214	ENST00000519058	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524214	ENST00000520266	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524214	ENST00000522534	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524214	ENST00000522874	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524214	ENST00000523231	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524214	ENST00000524214	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524214	ENST00000524370	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524214	ENST00000561150	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524370	ENST00000193029	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524370	ENST00000361847	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524370	ENST00000517966	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524370	ENST00000519058	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524370	ENST00000520266	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524370	ENST00000522534	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524370	ENST00000522874	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524370	ENST00000523231	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524370	ENST00000524214	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524370	ENST00000524370	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000524370	ENST00000561150	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000561150	ENST00000193029	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000561150	ENST00000361847	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000561150	ENST00000517966	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000561150	ENST00000519058	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000561150	ENST00000520266	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000561150	ENST00000522534	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000561150	ENST00000522874	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000561150	ENST00000523231	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000561150	ENST00000524214	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000561150	ENST00000524370	MOK	chr14	102698940	-	MOK	chr14	102699273	-
intron-intron	ENST00000561150	ENST00000561150	MOK	chr14	102698940	-	MOK	chr14	102699273	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for MOK-MOK

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MOK-MOK

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:102698940/:102699273)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MOK Q9UQ07	MOK Q9UQ07
FUNCTION: Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. {ECO:0000250\|UniProtKB:Q9WVS4}.	FUNCTION: Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. {ECO:0000250\|UniProtKB:Q9WVS4}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for MOK-MOK

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for MOK-MOK

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MOK-MOK

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MOK-MOK

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source