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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MOK-MUCL1 (FusionGDB2 ID:54559)

Fusion Gene Summary for MOK-MUCL1

check button Fusion gene summary
Fusion gene informationFusion gene name: MOK-MUCL1
Fusion gene ID: 54559
HgeneTgene
Gene symbol

MOK

MUCL1

Gene ID

5891

118430

Gene nameMOK protein kinasemucin like 1
SynonymsRAGE|RAGE-1|RAGE1|STK30SBEM
Cytomap

14q32.31

12q13.2

Type of geneprotein-codingprotein-coding
DescriptionMAPK/MAK/MRK overlapping kinaserenal cell carcinoma antigenrenal tumor antigen 1mucin-like protein 1small breast epithelial mucin
Modification date2020032020200313
UniProtAcc

Q9UQ07

Q96DR8

Ensembl transtripts involved in fusion geneENST00000361847, ENST00000522874, 
ENST00000524214, ENST00000193029, 
ENST00000517966, ENST00000519058, 
ENST00000520266, ENST00000522534, 
ENST00000522867, ENST00000523231, 
ENST00000524370, ENST00000561150, 
ENST00000308796, ENST00000546809, 
ENST00000547990, 
Fusion gene scores* DoF score11 X 9 X 6=5948 X 6 X 5=240
# samples 129
** MAII scorelog2(12/594*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MOK [Title/Abstract] AND MUCL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMOK(102771299)-MUCL1(55248900), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MOK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MUCL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A2IZ-01AMOKchr14

102771299

-MUCL1chr12

55248900

+
ChimerDB4SARCTCGA-DX-A2IZ-01AMOKchr14

102771299

-MUCL1chr12

55250554

+


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Fusion Gene ORF analysis for MOK-MUCL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000361847ENST00000308796MOKchr14

102771299

-MUCL1chr12

55248900

+
5CDS-3UTRENST00000361847ENST00000308796MOKchr14

102771299

-MUCL1chr12

55250554

+
5CDS-3UTRENST00000361847ENST00000546809MOKchr14

102771299

-MUCL1chr12

55248900

+
5CDS-3UTRENST00000361847ENST00000546809MOKchr14

102771299

-MUCL1chr12

55250554

+
5CDS-3UTRENST00000361847ENST00000547990MOKchr14

102771299

-MUCL1chr12

55248900

+
5CDS-3UTRENST00000361847ENST00000547990MOKchr14

102771299

-MUCL1chr12

55250554

+
5CDS-3UTRENST00000522874ENST00000308796MOKchr14

102771299

-MUCL1chr12

55248900

+
5CDS-3UTRENST00000522874ENST00000308796MOKchr14

102771299

-MUCL1chr12

55250554

+
5CDS-3UTRENST00000522874ENST00000546809MOKchr14

102771299

-MUCL1chr12

55248900

+
5CDS-3UTRENST00000522874ENST00000546809MOKchr14

102771299

-MUCL1chr12

55250554

+
5CDS-3UTRENST00000522874ENST00000547990MOKchr14

102771299

-MUCL1chr12

55248900

+
5CDS-3UTRENST00000522874ENST00000547990MOKchr14

102771299

-MUCL1chr12

55250554

+
5CDS-3UTRENST00000524214ENST00000308796MOKchr14

102771299

-MUCL1chr12

55248900

+
5CDS-3UTRENST00000524214ENST00000308796MOKchr14

102771299

-MUCL1chr12

55250554

+
5CDS-3UTRENST00000524214ENST00000546809MOKchr14

102771299

-MUCL1chr12

55248900

+
5CDS-3UTRENST00000524214ENST00000546809MOKchr14

102771299

-MUCL1chr12

55250554

+
5CDS-3UTRENST00000524214ENST00000547990MOKchr14

102771299

-MUCL1chr12

55248900

+
5CDS-3UTRENST00000524214ENST00000547990MOKchr14

102771299

-MUCL1chr12

55250554

+
5UTR-3UTRENST00000193029ENST00000308796MOKchr14

102771299

-MUCL1chr12

55248900

+
5UTR-3UTRENST00000193029ENST00000308796MOKchr14

102771299

-MUCL1chr12

55250554

+
5UTR-3UTRENST00000193029ENST00000546809MOKchr14

102771299

-MUCL1chr12

55248900

+
5UTR-3UTRENST00000193029ENST00000546809MOKchr14

102771299

-MUCL1chr12

55250554

+
5UTR-3UTRENST00000193029ENST00000547990MOKchr14

102771299

-MUCL1chr12

55248900

+
5UTR-3UTRENST00000193029ENST00000547990MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000517966ENST00000308796MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000517966ENST00000308796MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000517966ENST00000546809MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000517966ENST00000546809MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000517966ENST00000547990MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000517966ENST00000547990MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000519058ENST00000308796MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000519058ENST00000308796MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000519058ENST00000546809MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000519058ENST00000546809MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000519058ENST00000547990MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000519058ENST00000547990MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000520266ENST00000308796MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000520266ENST00000308796MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000520266ENST00000546809MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000520266ENST00000546809MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000520266ENST00000547990MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000520266ENST00000547990MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000522534ENST00000308796MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000522534ENST00000308796MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000522534ENST00000546809MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000522534ENST00000546809MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000522534ENST00000547990MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000522534ENST00000547990MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000522867ENST00000308796MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000522867ENST00000308796MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000522867ENST00000546809MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000522867ENST00000546809MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000522867ENST00000547990MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000522867ENST00000547990MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000523231ENST00000308796MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000523231ENST00000308796MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000523231ENST00000546809MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000523231ENST00000546809MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000523231ENST00000547990MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000523231ENST00000547990MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000524370ENST00000308796MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000524370ENST00000308796MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000524370ENST00000546809MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000524370ENST00000546809MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000524370ENST00000547990MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000524370ENST00000547990MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000561150ENST00000308796MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000561150ENST00000308796MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000561150ENST00000546809MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000561150ENST00000546809MOKchr14

102771299

-MUCL1chr12

55250554

+
intron-3UTRENST00000561150ENST00000547990MOKchr14

102771299

-MUCL1chr12

55248900

+
intron-3UTRENST00000561150ENST00000547990MOKchr14

102771299

-MUCL1chr12

55250554

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MOK-MUCL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MOK-MUCL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:102771299/:55248900)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MOK

Q9UQ07

MUCL1

Q96DR8

FUNCTION: Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. {ECO:0000250|UniProtKB:Q9WVS4}.FUNCTION: May play a role as marker for the diagnosis of metastatic breast cancer. {ECO:0000269|PubMed:12019145, ECO:0000269|PubMed:12595743, ECO:0000269|PubMed:15684711}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MOK-MUCL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MOK-MUCL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MOK-MUCL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MOK-MUCL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource