FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MON2-MELK (FusionGDB2 ID:54572)

Fusion Gene Summary for MON2-MELK

check button Fusion gene summary
Fusion gene informationFusion gene name: MON2-MELK
Fusion gene ID: 54572
HgeneTgene
Gene symbol

MON2

MELK

Gene ID

23041

9833

Gene nameMON2 homolog, regulator of endosome-to-Golgi traffickingmaternal embryonic leucine zipper kinase
Synonyms-HPK38
Cytomap

12q14.1

9p13.2

Type of geneprotein-codingprotein-coding
Descriptionprotein MON2 homologMON2 regulator of endosome-to-Golgi traffickingmaternal embryonic leucine zipper kinasepEg3 kinaseprotein kinase Eg3protein kinase PK38tyrosine-protein kinase MELK
Modification date2020031320200322
UniProtAcc

Q7Z3U7

Q14680

Ensembl transtripts involved in fusion geneENST00000393630, ENST00000393632, 
ENST00000546600, ENST00000280379, 
ENST00000393629, ENST00000549378, 
ENST00000551397, ENST00000552115, 
ENST00000552738, 		ENST00000298048, 
ENST00000487398, ENST00000536329, 
ENST00000536860, ENST00000536987, 
ENST00000538311, ENST00000541717, 
ENST00000543751, ENST00000545008, 
Fusion gene scores* DoF score18 X 13 X 7=163840 X 17 X 5=3400
# samples 1942
** MAII scorelog2(19/1638*10)=-3.10786403331006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(42/3400*10)=-3.01707351335894
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MON2 [Title/Abstract] AND MELK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMON2(62987058)-MELK(36616843), # samples:3
MELK(36616843)-MON2(62987058), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMELK

GO:0006915

apoptotic process

17280616

TgeneMELK

GO:0008283

cell proliferation

17280616

TgeneMELK

GO:0046777

protein autophosphorylation

16216881


check buttonFusion gene breakpoints across MON2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MELK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW019890MON2chr12

62987058

+MELKchr9

36616843

-
ChiTaRS5.0N/AAW020112MON2chr12

62987058

+MELKchr9

36616843

-
ChiTaRS5.0N/AAW021412MON2chr12

62987058

+MELKchr9

36616843

-


Top

Fusion Gene ORF analysis for MON2-MELK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000393630ENST00000298048MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393630ENST00000487398MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393630ENST00000536329MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393630ENST00000536860MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393630ENST00000536987MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393630ENST00000538311MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393630ENST00000541717MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393630ENST00000543751MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393630ENST00000545008MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393632ENST00000298048MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393632ENST00000487398MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393632ENST00000536329MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393632ENST00000536860MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393632ENST00000536987MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393632ENST00000538311MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393632ENST00000541717MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393632ENST00000543751MON2chr12

62987058

+MELKchr9

36616843

-
3UTR-intronENST00000393632ENST00000545008MON2chr12

62987058

+MELKchr9

36616843

-
5CDS-intronENST00000546600ENST00000298048MON2chr12

62987058

+MELKchr9

36616843

-
5CDS-intronENST00000546600ENST00000487398MON2chr12

62987058

+MELKchr9

36616843

-
5CDS-intronENST00000546600ENST00000536329MON2chr12

62987058

+MELKchr9

36616843

-
5CDS-intronENST00000546600ENST00000536860MON2chr12

62987058

+MELKchr9

36616843

-
5CDS-intronENST00000546600ENST00000536987MON2chr12

62987058

+MELKchr9

36616843

-
5CDS-intronENST00000546600ENST00000538311MON2chr12

62987058

+MELKchr9

36616843

-
5CDS-intronENST00000546600ENST00000541717MON2chr12

62987058

+MELKchr9

36616843

-
5CDS-intronENST00000546600ENST00000543751MON2chr12

62987058

+MELKchr9

36616843

-
5CDS-intronENST00000546600ENST00000545008MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000280379ENST00000298048MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000280379ENST00000487398MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000280379ENST00000536329MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000280379ENST00000536860MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000280379ENST00000536987MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000280379ENST00000538311MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000280379ENST00000541717MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000280379ENST00000543751MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000280379ENST00000545008MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000393629ENST00000298048MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000393629ENST00000487398MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000393629ENST00000536329MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000393629ENST00000536860MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000393629ENST00000536987MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000393629ENST00000538311MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000393629ENST00000541717MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000393629ENST00000543751MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000393629ENST00000545008MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000549378ENST00000298048MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000549378ENST00000487398MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000549378ENST00000536329MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000549378ENST00000536860MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000549378ENST00000536987MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000549378ENST00000538311MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000549378ENST00000541717MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000549378ENST00000543751MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000549378ENST00000545008MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000551397ENST00000298048MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000551397ENST00000487398MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000551397ENST00000536329MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000551397ENST00000536860MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000551397ENST00000536987MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000551397ENST00000538311MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000551397ENST00000541717MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000551397ENST00000543751MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000551397ENST00000545008MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552115ENST00000298048MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552115ENST00000487398MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552115ENST00000536329MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552115ENST00000536860MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552115ENST00000536987MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552115ENST00000538311MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552115ENST00000541717MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552115ENST00000543751MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552115ENST00000545008MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552738ENST00000298048MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552738ENST00000487398MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552738ENST00000536329MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552738ENST00000536860MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552738ENST00000536987MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552738ENST00000538311MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552738ENST00000541717MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552738ENST00000543751MON2chr12

62987058

+MELKchr9

36616843

-
intron-intronENST00000552738ENST00000545008MON2chr12

62987058

+MELKchr9

36616843

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for MON2-MELK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MON2-MELK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:62987058/:36616843)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MON2

Q7Z3U7

MELK

Q14680

FUNCTION: Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}.FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for MON2-MELK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for MON2-MELK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MON2-MELK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MON2-MELK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource