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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MORC2-APOC3 (FusionGDB2 ID:54586) |
Fusion Gene Summary for MORC2-APOC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MORC2-APOC3 | Fusion gene ID: 54586 | Hgene | Tgene | Gene symbol | MORC2 | APOC3 | Gene ID | 22880 | 345 |
| Gene name | MORC family CW-type zinc finger 2 | apolipoprotein C3 | |
| Synonyms | CMT2Z|ZCW3|ZCWCC1 | APOCIII | |
| Cytomap | 22q12.2 | 11q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ATPase MORC2zinc finger CW-type coiled-coil domain protein 1 | apolipoprotein C-III | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9Y6X9 | P02656 | |
| Ensembl transtripts involved in fusion gene | ENST00000215862, ENST00000397641, ENST00000469915, | ENST00000227667, ENST00000375345, ENST00000470144, | |
| Fusion gene scores | * DoF score | 2 X 3 X 3=18 | 4 X 3 X 3=36 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MORC2 [Title/Abstract] AND APOC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MORC2(31328637)-APOC3(116703480), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MORC2 | GO:0006338 | chromatin remodeling | 23260667 |
| Hgene | MORC2 | GO:0006974 | cellular response to DNA damage stimulus | 23260667 |
| Hgene | MORC2 | GO:0045814 | negative regulation of gene expression, epigenetic | 28581500|29211708 |
| Hgene | MORC2 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing | 28581500|29211708 |
| Tgene | APOC3 | GO:0007186 | G protein-coupled receptor signaling pathway | 16443932 |
| Tgene | APOC3 | GO:0010897 | negative regulation of triglyceride catabolic process | 3973011|18635818 |
| Tgene | APOC3 | GO:0010903 | negative regulation of very-low-density lipoprotein particle remodeling | 3973011 |
| Tgene | APOC3 | GO:0010916 | negative regulation of very-low-density lipoprotein particle clearance | 1917954 |
| Tgene | APOC3 | GO:0019433 | triglyceride catabolic process | 11060345 |
| Tgene | APOC3 | GO:0032489 | regulation of Cdc42 protein signal transduction | 16443932 |
| Tgene | APOC3 | GO:0033344 | cholesterol efflux | 11162594|16443932 |
| Tgene | APOC3 | GO:0033700 | phospholipid efflux | 11162594 |
| Tgene | APOC3 | GO:0034382 | chylomicron remnant clearance | 4020294 |
| Tgene | APOC3 | GO:0045717 | negative regulation of fatty acid biosynthetic process | 11060345|18635818 |
| Tgene | APOC3 | GO:0045833 | negative regulation of lipid metabolic process | 182536 |
| Tgene | APOC3 | GO:0048261 | negative regulation of receptor-mediated endocytosis | 1917954 |
| Tgene | APOC3 | GO:0050995 | negative regulation of lipid catabolic process | 15576844 |
| Tgene | APOC3 | GO:0051005 | negative regulation of lipoprotein lipase activity | 3973011|11060345|18635818 |
| Fusion gene breakpoints across MORC2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across APOC3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LIHC | TCGA-NI-A4U2-01A | MORC2 | chr22 | 31328637 | - | APOC3 | chr11 | 116703480 | + |
| ChimerDB4 | LIHC | TCGA-ZS-A9CE-01A | MORC2 | chr22 | 31328637 | - | APOC3 | chr11 | 116703480 | + |
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Fusion Gene ORF analysis for MORC2-APOC3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000215862 | ENST00000227667 | MORC2 | chr22 | 31328637 | - | APOC3 | chr11 | 116703480 | + |
| intron-3CDS | ENST00000215862 | ENST00000375345 | MORC2 | chr22 | 31328637 | - | APOC3 | chr11 | 116703480 | + |
| intron-3CDS | ENST00000397641 | ENST00000227667 | MORC2 | chr22 | 31328637 | - | APOC3 | chr11 | 116703480 | + |
| intron-3CDS | ENST00000397641 | ENST00000375345 | MORC2 | chr22 | 31328637 | - | APOC3 | chr11 | 116703480 | + |
| intron-3CDS | ENST00000469915 | ENST00000227667 | MORC2 | chr22 | 31328637 | - | APOC3 | chr11 | 116703480 | + |
| intron-3CDS | ENST00000469915 | ENST00000375345 | MORC2 | chr22 | 31328637 | - | APOC3 | chr11 | 116703480 | + |
| intron-intron | ENST00000215862 | ENST00000470144 | MORC2 | chr22 | 31328637 | - | APOC3 | chr11 | 116703480 | + |
| intron-intron | ENST00000397641 | ENST00000470144 | MORC2 | chr22 | 31328637 | - | APOC3 | chr11 | 116703480 | + |
| intron-intron | ENST00000469915 | ENST00000470144 | MORC2 | chr22 | 31328637 | - | APOC3 | chr11 | 116703480 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for MORC2-APOC3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MORC2-APOC3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:31328637/:116703480) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MORC2 | APOC3 |
| FUNCTION: Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20225202, PubMed:20110259). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:24286864, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:29440755}. | FUNCTION: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013). {ECO:0000269|PubMed:18408013, ECO:0000303|PubMed:18201179, ECO:0000303|PubMed:22510806}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for MORC2-APOC3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for MORC2-APOC3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MORC2-APOC3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MORC2-APOC3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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