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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MORC3-PTK2 (FusionGDB2 ID:54594)

Fusion Gene Summary for MORC3-PTK2

check button Fusion gene summary
Fusion gene informationFusion gene name: MORC3-PTK2
Fusion gene ID: 54594
HgeneTgene
Gene symbol

MORC3

PTK2

Gene ID

23515

5747

Gene nameMORC family CW-type zinc finger 3protein tyrosine kinase 2
SynonymsNXP2|ZCW5|ZCWCC3FADK|FAK|FAK1|FRNK|PPP1R71|p125FAK|pp125FAK
Cytomap

21q22.12

8q24.3

Type of geneprotein-codingprotein-coding
DescriptionMORC family CW-type zinc finger protein 3nuclear matrix protein 2nuclear matrix protein NXP2zinc finger CW-type coiled-coil domain protein 3zinc finger, CW type with coiled-coil domain 3focal adhesion kinase 1FADK 1FAK-related non-kinase polypeptidePTK2 protein tyrosine kinase 2focal adhesion kinase isoform FAK-Del33focal adhesion kinase-related nonkinaseprotein phosphatase 1 regulatory subunit 71
Modification date2020032020200327
UniProtAcc

Q14149

.
Ensembl transtripts involved in fusion geneENST00000487909, ENST00000400485, 
ENST00000340930, ENST00000395218, 
ENST00000430260, ENST00000517887, 
ENST00000519419, ENST00000519465, 
ENST00000521059, ENST00000522684, 
ENST00000535192, ENST00000538769, 
ENST00000517712, ENST00000519635, 
ENST00000519881, ENST00000520151, 
ENST00000520892, ENST00000522950, 
Fusion gene scores* DoF score9 X 8 X 9=64819 X 20 X 13=4940
# samples 1229
** MAII scorelog2(12/648*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/4940*10)=-4.09038623645711
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MORC3 [Title/Abstract] AND PTK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMORC3(37717329)-PTK2(141685598), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMORC3

GO:0006468

protein phosphorylation

17332504

HgeneMORC3

GO:0007569

cell aging

17332504

HgeneMORC3

GO:0018105

peptidyl-serine phosphorylation

17332504

HgeneMORC3

GO:0048147

negative regulation of fibroblast proliferation

17332504

HgeneMORC3

GO:0050821

protein stabilization

17332504

HgeneMORC3

GO:0051457

maintenance of protein location in nucleus

17332504

TgenePTK2

GO:0007179

transforming growth factor beta receptor signaling pathway

24036928

TgenePTK2

GO:0007229

integrin-mediated signaling pathway

24036928

TgenePTK2

GO:0010763

positive regulation of fibroblast migration

26763945

TgenePTK2

GO:0018108

peptidyl-tyrosine phosphorylation

10655584|11331870

TgenePTK2

GO:0022408

negative regulation of cell-cell adhesion

21703394

TgenePTK2

GO:0030335

positive regulation of cell migration

11331870|21703394

TgenePTK2

GO:0033628

regulation of cell adhesion mediated by integrin

10655584

TgenePTK2

GO:0046777

protein autophosphorylation

10655584|11331870

TgenePTK2

GO:0048013

ephrin receptor signaling pathway

10655584

TgenePTK2

GO:0060396

growth hormone receptor signaling pathway

10925297

TgenePTK2

GO:0090303

positive regulation of wound healing

26763945


check buttonFusion gene breakpoints across MORC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-KN-8434-11AMORC3chr21

37717329

+PTK2chr8

141685598

-


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Fusion Gene ORF analysis for MORC3-PTK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000487909ENST00000340930MORC3chr21

37717329

+PTK2chr8

141685598

-
3UTR-3CDSENST00000487909ENST00000395218MORC3chr21

37717329

+PTK2chr8

141685598

-
3UTR-3CDSENST00000487909ENST00000430260MORC3chr21

37717329

+PTK2chr8

141685598

-
3UTR-3CDSENST00000487909ENST00000517887MORC3chr21

37717329

+PTK2chr8

141685598

-
3UTR-3CDSENST00000487909ENST00000519419MORC3chr21

37717329

+PTK2chr8

141685598

-
3UTR-3CDSENST00000487909ENST00000519465MORC3chr21

37717329

+PTK2chr8

141685598

-
3UTR-3CDSENST00000487909ENST00000521059MORC3chr21

37717329

+PTK2chr8

141685598

-
3UTR-3CDSENST00000487909ENST00000522684MORC3chr21

37717329

+PTK2chr8

141685598

-
3UTR-3CDSENST00000487909ENST00000535192MORC3chr21

37717329

+PTK2chr8

141685598

-
3UTR-3CDSENST00000487909ENST00000538769MORC3chr21

37717329

+PTK2chr8

141685598

-
3UTR-intronENST00000487909ENST00000517712MORC3chr21

37717329

+PTK2chr8

141685598

-
3UTR-intronENST00000487909ENST00000519635MORC3chr21

37717329

+PTK2chr8

141685598

-
3UTR-intronENST00000487909ENST00000519881MORC3chr21

37717329

+PTK2chr8

141685598

-
3UTR-intronENST00000487909ENST00000520151MORC3chr21

37717329

+PTK2chr8

141685598

-
3UTR-intronENST00000487909ENST00000520892MORC3chr21

37717329

+PTK2chr8

141685598

-
3UTR-intronENST00000487909ENST00000522950MORC3chr21

37717329

+PTK2chr8

141685598

-
5CDS-intronENST00000400485ENST00000517712MORC3chr21

37717329

+PTK2chr8

141685598

-
5CDS-intronENST00000400485ENST00000519635MORC3chr21

37717329

+PTK2chr8

141685598

-
5CDS-intronENST00000400485ENST00000519881MORC3chr21

37717329

+PTK2chr8

141685598

-
5CDS-intronENST00000400485ENST00000520151MORC3chr21

37717329

+PTK2chr8

141685598

-
5CDS-intronENST00000400485ENST00000520892MORC3chr21

37717329

+PTK2chr8

141685598

-
5CDS-intronENST00000400485ENST00000522950MORC3chr21

37717329

+PTK2chr8

141685598

-
In-frameENST00000400485ENST00000340930MORC3chr21

37717329

+PTK2chr8

141685598

-
In-frameENST00000400485ENST00000395218MORC3chr21

37717329

+PTK2chr8

141685598

-
In-frameENST00000400485ENST00000430260MORC3chr21

37717329

+PTK2chr8

141685598

-
In-frameENST00000400485ENST00000517887MORC3chr21

37717329

+PTK2chr8

141685598

-
In-frameENST00000400485ENST00000519419MORC3chr21

37717329

+PTK2chr8

141685598

-
In-frameENST00000400485ENST00000519465MORC3chr21

37717329

+PTK2chr8

141685598

-
In-frameENST00000400485ENST00000521059MORC3chr21

37717329

+PTK2chr8

141685598

-
In-frameENST00000400485ENST00000522684MORC3chr21

37717329

+PTK2chr8

141685598

-
In-frameENST00000400485ENST00000535192MORC3chr21

37717329

+PTK2chr8

141685598

-
In-frameENST00000400485ENST00000538769MORC3chr21

37717329

+PTK2chr8

141685598

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400485MORC3chr2137717329+ENST00000522684PTK2chr8141685598-32441081761677533
ENST00000400485MORC3chr2137717329+ENST00000535192PTK2chr8141685598-27531081761677533
ENST00000400485MORC3chr2137717329+ENST00000519465PTK2chr8141685598-27421081761677533
ENST00000400485MORC3chr2137717329+ENST00000517887PTK2chr8141685598-27421081761677533
ENST00000400485MORC3chr2137717329+ENST00000521059PTK2chr8141685598-27421081761677533
ENST00000400485MORC3chr2137717329+ENST00000395218PTK2chr8141685598-27811081761716546
ENST00000400485MORC3chr2137717329+ENST00000538769PTK2chr8141685598-27391081761677533
ENST00000400485MORC3chr2137717329+ENST00000340930PTK2chr8141685598-27781081761716546
ENST00000400485MORC3chr2137717329+ENST00000519419PTK2chr8141685598-25141081761677533
ENST00000400485MORC3chr2137717329+ENST00000430260PTK2chr8141685598-20711081761677533

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400485ENST00000522684MORC3chr2137717329+PTK2chr8141685598-0.0006297890.9993703
ENST00000400485ENST00000535192MORC3chr2137717329+PTK2chr8141685598-0.0005925960.9994074
ENST00000400485ENST00000519465MORC3chr2137717329+PTK2chr8141685598-0.0006226430.9993774
ENST00000400485ENST00000517887MORC3chr2137717329+PTK2chr8141685598-0.0006226430.9993774
ENST00000400485ENST00000521059MORC3chr2137717329+PTK2chr8141685598-0.0006226430.9993774
ENST00000400485ENST00000395218MORC3chr2137717329+PTK2chr8141685598-0.0005621010.99943787
ENST00000400485ENST00000538769MORC3chr2137717329+PTK2chr8141685598-0.0006290390.999371
ENST00000400485ENST00000340930MORC3chr2137717329+PTK2chr8141685598-0.0005461770.99945384
ENST00000400485ENST00000519419MORC3chr2137717329+PTK2chr8141685598-0.0010681150.9989318
ENST00000400485ENST00000430260MORC3chr2137717329+PTK2chr8141685598-0.0016225330.99837744

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Fusion Genomic Features for MORC3-PTK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MORC3-PTK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:37717329/chr8:141685598)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MORC3

Q14149

.
FUNCTION: Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26202233, ECO:0000269|PubMed:26933034}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTK2chr21:37717329chr8:141685598ENST000003409302633863_9138541066.0Compositional biasNote=Pro-rich
TgenePTK2chr21:37717329chr8:141685598ENST000005210592632863_9138541053.0Compositional biasNote=Pro-rich
TgenePTK2chr21:37717329chr8:141685598ENST000005226842632863_9138541053.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMORC3chr21:37717329chr8:141685598ENST00000400485+817686_877335940.0Coiled coilOntology_term=ECO:0000255
HgeneMORC3chr21:37717329chr8:141685598ENST00000400485+817326_353335940.0RegionNuclear matrix binding
HgeneMORC3chr21:37717329chr8:141685598ENST00000400485+817500_591335940.0RegionRNA binding
HgeneMORC3chr21:37717329chr8:141685598ENST00000400485+817404_454335940.0Zinc fingerCW-type
TgenePTK2chr21:37717329chr8:141685598ENST000003409302633712_7338541066.0Compositional biasNote=Pro-rich
TgenePTK2chr21:37717329chr8:141685598ENST000005210592632712_7338541053.0Compositional biasNote=Pro-rich
TgenePTK2chr21:37717329chr8:141685598ENST000005226842632712_7338541053.0Compositional biasNote=Pro-rich
TgenePTK2chr21:37717329chr8:141685598ENST00000340930263335_3558541066.0DomainFERM
TgenePTK2chr21:37717329chr8:141685598ENST000003409302633422_6808541066.0DomainProtein kinase
TgenePTK2chr21:37717329chr8:141685598ENST00000521059263235_3558541053.0DomainFERM
TgenePTK2chr21:37717329chr8:141685598ENST000005210592632422_6808541053.0DomainProtein kinase
TgenePTK2chr21:37717329chr8:141685598ENST00000522684263235_3558541053.0DomainFERM
TgenePTK2chr21:37717329chr8:141685598ENST000005226842632422_6808541053.0DomainProtein kinase
TgenePTK2chr21:37717329chr8:141685598ENST000003409302633428_4348541066.0Nucleotide bindingATP
TgenePTK2chr21:37717329chr8:141685598ENST000003409302633500_5028541066.0Nucleotide bindingATP
TgenePTK2chr21:37717329chr8:141685598ENST000005210592632428_4348541053.0Nucleotide bindingATP
TgenePTK2chr21:37717329chr8:141685598ENST000005210592632500_5028541053.0Nucleotide bindingATP
TgenePTK2chr21:37717329chr8:141685598ENST000005226842632428_4348541053.0Nucleotide bindingATP
TgenePTK2chr21:37717329chr8:141685598ENST000005226842632500_5028541053.0Nucleotide bindingATP


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Fusion Gene Sequence for MORC3-PTK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54594_54594_1_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000340930_length(transcript)=2778nt_BP=1081nt
AGGGCTCCACAGTCGTTCCGCCACCTCCCAGTCGGGTTGCGGCGGAGGCCGTTCCTGGCTTTGTAGCTCGCTCAAGATGGCGGCGCAGCC
ACCCCGCGGGATACGCCTCAGCGCGCTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGA
ATTAATAGATAATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATATGCTTGACATT
CACCGACAATGGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATGAATGGTCATGT
CCCAGTTGGATTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAATGGAGAAAGCAT
GAGCGTGGGCCTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAACAAGCACCGACA
GATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACT
TGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGA
TAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCC
TGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGAC
ACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATTACCTTTGGATT
CAACTGCAGAAATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAG
GATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGGTAAAGAAGAAAAGAATTGGGCGGAAAGAAATCCTGCAGCTCCACCAAA
GAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAAGCC
ATGGAGGCTTCAGCCCCAGGAAATCAGCCCCCCTCCTACTGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCT
GGTGAAAGCTGTCATCGAGATGTCCAGTAAAATCCAGCCAGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCT
GAGGACATTATTGGCCACTGTGGATGAGACCATTCCCCTCCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAA
CTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCT
GACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACC
ACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGT
CCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATT
TGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTA
TATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATT
CCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACC
ATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGC
TATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATT
GGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTC
TTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAAT
TTATAAAGAAAGATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATG
AAGCAAAACAGGAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGT

>54594_54594_1_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000340930_length(amino acids)=546AA_BP=335
MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVT
MNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQK
LLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRG
QKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRIGNQHIYQPVGKPGKEEKNWAERNP
AAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKPWRLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKE
VGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKML

--------------------------------------------------------------
>54594_54594_2_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000395218_length(transcript)=2781nt_BP=1081nt
AGGGCTCCACAGTCGTTCCGCCACCTCCCAGTCGGGTTGCGGCGGAGGCCGTTCCTGGCTTTGTAGCTCGCTCAAGATGGCGGCGCAGCC
ACCCCGCGGGATACGCCTCAGCGCGCTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGA
ATTAATAGATAATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATATGCTTGACATT
CACCGACAATGGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATGAATGGTCATGT
CCCAGTTGGATTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAATGGAGAAAGCAT
GAGCGTGGGCCTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAACAAGCACCGACA
GATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACT
TGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGA
TAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCC
TGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGAC
ACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATTACCTTTGGATT
CAACTGCAGAAATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAG
GATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGGTAAAGAAGAAAAGAATTGGGCGGAAAGAAATCCTGCAGCTCCACCAAA
GAAACCGCCTCGCCCTGGAGCTCCCGGTCATCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAAGCC
AAATCAGCTTCAGCCCCAGGAAATCAGCCCCCCTCCTACTGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCT
GGTGAAAGCTGTCATCGAGATGTCCAGTAAAATCCAGCCAGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCT
GAGGACATTATTGGCCACTGTGGATGAGACCATTCCCCTCCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAA
CTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGCCCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCT
GACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTTACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACC
ACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCTTTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGT
CCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAATGACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATT
TGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATATTCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTA
TATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTTCACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATT
CCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCATGAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACC
ATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTAGAACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGC
TATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTACAGCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATT
GGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTCATGTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTC
TTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAAACTGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAAT
TTATAAAGAAAGATTAAAGCCATGTTGACTATTTTACAGCCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATG
AAGCAAAACAGGAATTTGGTTTTCTTTTGATGTCCAGTTACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGT

>54594_54594_2_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000395218_length(amino acids)=546AA_BP=335
MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVT
MNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQK
LLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRG
QKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRIGNQHIYQPVGKPGKEEKNWAERNP
AAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKPNQLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKE
VGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKML

--------------------------------------------------------------
>54594_54594_3_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000430260_length(transcript)=2071nt_BP=1081nt
AGGGCTCCACAGTCGTTCCGCCACCTCCCAGTCGGGTTGCGGCGGAGGCCGTTCCTGGCTTTGTAGCTCGCTCAAGATGGCGGCGCAGCC
ACCCCGCGGGATACGCCTCAGCGCGCTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGA
ATTAATAGATAATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATATGCTTGACATT
CACCGACAATGGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATGAATGGTCATGT
CCCAGTTGGATTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAATGGAGAAAGCAT
GAGCGTGGGCCTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAACAAGCACCGACA
GATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACT
TGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGA
TAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCC
TGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGAC
ACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATTACCTTTGGATT
CAACTGCAGAAATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAG
GATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCA
TCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAAGCTTCAGCCCCAGGAAATCAGCCCCCCTCCTAC
TGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAAAGCTGTCATCGAGATGTCCAGTAAAATCCAGCC
AGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGACATTATTGGCCACTGTGGATGAGACCATTCCCCT
CCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGC
CCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTT
ACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCT
TTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAAT
GACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATAT
TCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTT
CACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCAT

>54594_54594_3_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000430260_length(amino acids)=533AA_BP=335
MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVT
MNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQK
LLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRG
QKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRIGNQHIYQPVGKPDPAAPPKKPPRP
GAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVD

--------------------------------------------------------------
>54594_54594_4_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000517887_length(transcript)=2742nt_BP=1081nt
AGGGCTCCACAGTCGTTCCGCCACCTCCCAGTCGGGTTGCGGCGGAGGCCGTTCCTGGCTTTGTAGCTCGCTCAAGATGGCGGCGCAGCC
ACCCCGCGGGATACGCCTCAGCGCGCTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGA
ATTAATAGATAATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATATGCTTGACATT
CACCGACAATGGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATGAATGGTCATGT
CCCAGTTGGATTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAATGGAGAAAGCAT
GAGCGTGGGCCTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAACAAGCACCGACA
GATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACT
TGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGA
TAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCC
TGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGAC
ACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATTACCTTTGGATT
CAACTGCAGAAATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAG
GATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCA
TCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAAGCTTCAGCCCCAGGAAATCAGCCCCCCTCCTAC
TGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAAAGCTGTCATCGAGATGTCCAGTAAAATCCAGCC
AGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGACATTATTGGCCACTGTGGATGAGACCATTCCCCT
CCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGC
CCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTT
ACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCT
TTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAAT
GACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATAT
TCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTT
CACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCAT
GAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTAGA
ACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTACA
GCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTCAT
GTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAAAC
TGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAAAGAAAGATTAAAGCCATGTTGACTATTTTACAG
CCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAAAACAGGAATTTGGTTTTCTTTTGATGTCCAGTT
ACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGGATATAAATTATTCTCAGGAAGAATATAATGAAC

>54594_54594_4_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000517887_length(amino acids)=533AA_BP=335
MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVT
MNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQK
LLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRG
QKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRIGNQHIYQPVGKPDPAAPPKKPPRP
GAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVD

--------------------------------------------------------------
>54594_54594_5_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000519419_length(transcript)=2514nt_BP=1081nt
AGGGCTCCACAGTCGTTCCGCCACCTCCCAGTCGGGTTGCGGCGGAGGCCGTTCCTGGCTTTGTAGCTCGCTCAAGATGGCGGCGCAGCC
ACCCCGCGGGATACGCCTCAGCGCGCTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGA
ATTAATAGATAATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATATGCTTGACATT
CACCGACAATGGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATGAATGGTCATGT
CCCAGTTGGATTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAATGGAGAAAGCAT
GAGCGTGGGCCTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAACAAGCACCGACA
GATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACT
TGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGA
TAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCC
TGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGAC
ACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATTACCTTTGGATT
CAACTGCAGAAATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAG
GATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCA
TCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAAGCTTCAGCCCCAGGAAATCAGCCCCCCTCCTAC
TGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAAAGCTGTCATCGAGATGTCCAGTAAAATCCAGCC
AGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGACATTATTGGCCACTGTGGATGAGACCATTCCCCT
CCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGC
CCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTT
ACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCT
TTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAAT
GACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATAT
TCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTT
CACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCAT
GAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTAGA
ACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTACA
GCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTCAT
GTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAAAC

>54594_54594_5_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000519419_length(amino acids)=533AA_BP=335
MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVT
MNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQK
LLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRG
QKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRIGNQHIYQPVGKPDPAAPPKKPPRP
GAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVD

--------------------------------------------------------------
>54594_54594_6_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000519465_length(transcript)=2742nt_BP=1081nt
AGGGCTCCACAGTCGTTCCGCCACCTCCCAGTCGGGTTGCGGCGGAGGCCGTTCCTGGCTTTGTAGCTCGCTCAAGATGGCGGCGCAGCC
ACCCCGCGGGATACGCCTCAGCGCGCTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGA
ATTAATAGATAATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATATGCTTGACATT
CACCGACAATGGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATGAATGGTCATGT
CCCAGTTGGATTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAATGGAGAAAGCAT
GAGCGTGGGCCTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAACAAGCACCGACA
GATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACT
TGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGA
TAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCC
TGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGAC
ACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATTACCTTTGGATT
CAACTGCAGAAATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAG
GATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCA
TCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAAGCTTCAGCCCCAGGAAATCAGCCCCCCTCCTAC
TGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAAAGCTGTCATCGAGATGTCCAGTAAAATCCAGCC
AGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGACATTATTGGCCACTGTGGATGAGACCATTCCCCT
CCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGC
CCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTT
ACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCT
TTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAAT
GACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATAT
TCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTT
CACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCAT
GAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTAGA
ACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTACA
GCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTCAT
GTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAAAC
TGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAAAGAAAGATTAAAGCCATGTTGACTATTTTACAG
CCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAAAACAGGAATTTGGTTTTCTTTTGATGTCCAGTT
ACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGGATATAAATTATTCTCAGGAAGAATATAATGAAC

>54594_54594_6_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000519465_length(amino acids)=533AA_BP=335
MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVT
MNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQK
LLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRG
QKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRIGNQHIYQPVGKPDPAAPPKKPPRP
GAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVD

--------------------------------------------------------------
>54594_54594_7_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000521059_length(transcript)=2742nt_BP=1081nt
AGGGCTCCACAGTCGTTCCGCCACCTCCCAGTCGGGTTGCGGCGGAGGCCGTTCCTGGCTTTGTAGCTCGCTCAAGATGGCGGCGCAGCC
ACCCCGCGGGATACGCCTCAGCGCGCTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGA
ATTAATAGATAATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATATGCTTGACATT
CACCGACAATGGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATGAATGGTCATGT
CCCAGTTGGATTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAATGGAGAAAGCAT
GAGCGTGGGCCTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAACAAGCACCGACA
GATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACT
TGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGA
TAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCC
TGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGAC
ACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATTACCTTTGGATT
CAACTGCAGAAATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAG
GATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCA
TCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAAGCTTCAGCCCCAGGAAATCAGCCCCCCTCCTAC
TGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAAAGCTGTCATCGAGATGTCCAGTAAAATCCAGCC
AGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGACATTATTGGCCACTGTGGATGAGACCATTCCCCT
CCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGC
CCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTT
ACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCT
TTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAAT
GACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATAT
TCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTT
CACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCAT
GAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTAGA
ACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTACA
GCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTCAT
GTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAAAC
TGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAAAGAAAGATTAAAGCCATGTTGACTATTTTACAG
CCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAAAACAGGAATTTGGTTTTCTTTTGATGTCCAGTT
ACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGGATATAAATTATTCTCAGGAAGAATATAATGAAC

>54594_54594_7_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000521059_length(amino acids)=533AA_BP=335
MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVT
MNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQK
LLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRG
QKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRIGNQHIYQPVGKPDPAAPPKKPPRP
GAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVD

--------------------------------------------------------------
>54594_54594_8_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000522684_length(transcript)=3244nt_BP=1081nt
AGGGCTCCACAGTCGTTCCGCCACCTCCCAGTCGGGTTGCGGCGGAGGCCGTTCCTGGCTTTGTAGCTCGCTCAAGATGGCGGCGCAGCC
ACCCCGCGGGATACGCCTCAGCGCGCTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGA
ATTAATAGATAATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATATGCTTGACATT
CACCGACAATGGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATGAATGGTCATGT
CCCAGTTGGATTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAATGGAGAAAGCAT
GAGCGTGGGCCTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAACAAGCACCGACA
GATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACT
TGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGA
TAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCC
TGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGAC
ACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATTACCTTTGGATT
CAACTGCAGAAATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAG
GATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCA
TCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAAGCTTCAGCCCCAGGAAATCAGCCCCCCTCCTAC
TGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAAAGCTGTCATCGAGATGTCCAGTAAAATCCAGCC
AGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGACATTATTGGCCACTGTGGATGAGACCATTCCCCT
CCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGC
CCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTT
ACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCT
TTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAAT
GACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATAT
TCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTT
CACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCAT
GAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTAGA
ACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTACA
GCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTCAT
GTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAAAC
TGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAAAGAAAGATTAAAGCCATGTTGACTATTTTACAG
CCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAAAACAGGAATTTGGTTTTCTTTTGATGTCCAGTT
ACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGGATATAAATTATTCTCAGGAAGAATATAATGAAC
TGTACAGTTACTTTGACCTATTAAAAAGGTGTTACCAGTAAAGTTCTTGTTGTAATATCCTTTCTTTTGGTTCTGTTTCTTCAGATGGCT
TTTCAGGTGACTTGTCAGATAAGATAACATACAAGAGAGTTCCCAATAATTATCAGGAAGCCTCTCACTAATTAGTTTCTTTTTTTTTAT
TTAATCTTCTAAACAAGTCAAGGATGTTACCACAGAAGGGTAGCGTGGCGTAAGTTAACCTTTTCATTCCATCGTCACCTATTAAATGCA
GAGCTCAGGATGGAAGTAGCAATGGTCTTCAATGAAAGAACCTTCCCCTGCGCAGGGTCTCACTATTCCGCTAACTCGGACTCAAAGCAT
AATTCACTTGTCAAGGAAATTGTTAGCATTTCCCAGGCCCACCCTAGTCTTGCTAGAATCTCTGTGAGCCACAGAGCAGGGAGCAAATAG
AACTGAGATCTCCAGCACTAGGGACTCAGACTCCAAAGGGAGGGATTTGAGTGAATTTTTTCCAGGTAAATACATGCTCTTATGTGCAAA

>54594_54594_8_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000522684_length(amino acids)=533AA_BP=335
MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVT
MNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQK
LLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRG
QKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRIGNQHIYQPVGKPDPAAPPKKPPRP
GAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVD

--------------------------------------------------------------
>54594_54594_9_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000535192_length(transcript)=2753nt_BP=1081nt
AGGGCTCCACAGTCGTTCCGCCACCTCCCAGTCGGGTTGCGGCGGAGGCCGTTCCTGGCTTTGTAGCTCGCTCAAGATGGCGGCGCAGCC
ACCCCGCGGGATACGCCTCAGCGCGCTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGA
ATTAATAGATAATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATATGCTTGACATT
CACCGACAATGGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATGAATGGTCATGT
CCCAGTTGGATTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAATGGAGAAAGCAT
GAGCGTGGGCCTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAACAAGCACCGACA
GATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACT
TGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGA
TAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCC
TGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGAC
ACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATTACCTTTGGATT
CAACTGCAGAAATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAG
GATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCA
TCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAAGCTTCAGCCCCAGGAAATCAGCCCCCCTCCTAC
TGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAAAGCTGTCATCGAGATGTCCAGTAAAATCCAGCC
AGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGACATTATTGGCCACTGTGGATGAGACCATTCCCCT
CCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGC
CCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTT
ACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCT
TTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAAT
GACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATAT
TCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTT
CACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCAT
GAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTAGA
ACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTACA
GCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTCAT
GTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAAAC
TGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAAAGAAAGATTAAAGCCATGTTGACTATTTTACAG
CCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAAAACAGGAATTTGGTTTTCTTTTGATGTCCAGTT
ACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGGATATAAATTATTCTCAGGAAGAATATAATGAAC

>54594_54594_9_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000535192_length(amino acids)=533AA_BP=335
MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVT
MNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQK
LLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRG
QKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRIGNQHIYQPVGKPDPAAPPKKPPRP
GAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVD

--------------------------------------------------------------
>54594_54594_10_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000538769_length(transcript)=2739nt_BP=1081nt
AGGGCTCCACAGTCGTTCCGCCACCTCCCAGTCGGGTTGCGGCGGAGGCCGTTCCTGGCTTTGTAGCTCGCTCAAGATGGCGGCGCAGCC
ACCCCGCGGGATACGCCTCAGCGCGCTTTGCCCGAAGTTTTTACATACAAATTCTACTAGTCACACCTGGCCATTCAGTGCAGTTGCTGA
ATTAATAGATAATGCTTATGATCCTGATGTGAACGCTAAACAAATATGGATTGACAAAACAGTGATAAATGACCATATATGCTTGACATT
CACCGACAATGGGAATGGTATGACTTCTGATAAATTACATAAAATGCTAAGCTTTGGCTTCAGTGACAAAGTCACCATGAATGGTCATGT
CCCAGTTGGATTATATGGGAATGGCTTCAAGTCGGGTTCTATGCGTCTGGGTAAAGACGCAATCGTTTTTACCAAAAATGGAGAAAGCAT
GAGCGTGGGCCTTTTGTCTCAGACCTACTTGGAAGTCATAAAAGCGGAGCATGTTGTTGTTCCAATAGTGGCATTCAACAAGCACCGACA
GATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACT
TGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGA
TAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCC
TGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGAC
ACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTATCTAAAACAGTGAGAATTACCTTTGGATT
CAACTGCAGAAATAAAGATCATTATGGGATAATGATGTATCACAGAAATAGACTCATCAAAGCTTATGAAAAAGTTGGATGTCAGTTAAG
GATTGGAAACCAACATATATATCAGCCTGTGGGTAAACCAGATCCTGCAGCTCCACCAAAGAAACCGCCTCGCCCTGGAGCTCCCGGTCA
TCTGGGAAGCCTTGCCAGCCTCAGCAGCCCTGCTGACAGCTACAACGAGGGTGTCAAGCTTCAGCCCCAGGAAATCAGCCCCCCTCCTAC
TGCCAACCTGGACCGGTCGAATGATAAGGTGTACGAGAATGTGACGGGCCTGGTGAAAGCTGTCATCGAGATGTCCAGTAAAATCCAGCC
AGCCCCACCAGAGGAGTATGTCCCTATGGTGAAGGAAGTCGGCTTGGCCCTGAGGACATTATTGGCCACTGTGGATGAGACCATTCCCCT
CCTACCAGCCAGCACCCACCGAGAGATTGAGATGGCACAGAAGCTATTGAACTCTGACCTGGGTGAGCTCATCAACAAGATGAAACTGGC
CCAGCAGTATGTCATGACCAGCCTCCAGCAAGAGTACAAAAAGCAAATGCTGACTGCTGCTCACGCCCTGGCTGTGGATGCCAAAAACTT
ACTCGATGTCATTGACCAAGCAAGACTGAAAATGCTTGGGCAGACGAGACCACACTGAGCCTCCCCTAGGAGCACGTCTTGCTACCCTCT
TTTGAAGATGTTCTCTAGCCTTCCACCAGCAGCGAGGAATTAACCCTGTGTCCTCAGTCGCCAGCACTTACAGCTCCAACTTTTTTGAAT
GACCATCTGGTTGAAAAATCTTTCTCATATAAGTTTAACCACACTTTGATTTGGGTTCATTTTTTGTTTTGTTTTTTTCAATCATGATAT
TCAGAAAAATCCAGGATCCAAAATGTGGCGTTTTTCTAAGAATGAAAATTATATGTAAGCTTTTAAGCATCATGAAGAACAATTTATGTT
CACATTAAGATACGTTCTAAAGGGGGATGGCCAAGGGGTGACATCTTAATTCCTAAACTACCTTAGCTGCATAGTGGAAGAGGAGAGCAT
GAAGCAAAGAATTCCAGGAAACCCAAGAGGCTGAGAATTCTTTTGTCTACCATAGAATTATTATCCAGACTGGAATTTTTGTTTGTTAGA
ACACCCTTCAGTTGCAATATGCTAATCCCACTTTACAAAGAATATAAAAGCTATATTTTGAAGACTTGAGTTATTTCAGAAAAAACTACA
GCCCTTTTTGTCTTACCTGCCTTTTACTTTCGTGTGGATATGTGAAGCATTGGGTCGGGAACTAGCTGTAGAACACAACTAAAAACTCAT
GTCTTTTTTCACAGAATAATGTGCCAGTTTTTTGTAGCAATGTTATTTCTCTTGGAAGCAGAAATGCTTTGTACCAGAGCACCTCCAAAC
TGCATTGAGGAGAAGTTCCAGAACCATCCCCTTTTTCCATTTTTATATAATTTATAAAGAAAGATTAAAGCCATGTTGACTATTTTACAG
CCACTGGAGTTAACTAACCCTTCCTTGTATCTGTCTTCCCAGGAGAGAATGAAGCAAAACAGGAATTTGGTTTTCTTTTGATGTCCAGTT
ACACCATCCATTCTGTTAATTTTGAAAAAATATACCCTCCCTTTAGTTTGTTGGGGGATATAAATTATTCTCAGGAAGAATATAATGAAC

>54594_54594_10_MORC3-PTK2_MORC3_chr21_37717329_ENST00000400485_PTK2_chr8_141685598_ENST00000538769_length(amino acids)=533AA_BP=335
MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVT
MNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQK
LLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRG
QKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRIGNQHIYQPVGKPDPAAPPKKPPRP
GAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MORC3-PTK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePTK2chr21:37717329chr8:141685598ENST000003409302633912_1052854.01066.0ARHGEF28
TgenePTK2chr21:37717329chr8:141685598ENST000005210592632912_1052854.01053.0ARHGEF28
TgenePTK2chr21:37717329chr8:141685598ENST000005226842632912_1052854.01053.0ARHGEF28


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MORC3-PTK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MORC3-PTK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource