FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MORF4L1-DCLK1 (FusionGDB2 ID:54600)

Fusion Gene Summary for MORF4L1-DCLK1

check button Fusion gene summary
Fusion gene informationFusion gene name: MORF4L1-DCLK1
Fusion gene ID: 54600
HgeneTgene
Gene symbol

MORF4L1

DCLK1

Gene ID

10933

9201

Gene namemortality factor 4 like 1doublecortin like kinase 1
SynonymsEaf3|FWP006|HsT17725|MEAF3|MORFRG15|MRG15|S863-6CL1|CLICK1|DCAMKL1|DCDC3A|DCLK
Cytomap

15q25.1

13q13.3

Type of geneprotein-codingprotein-coding
Descriptionmortality factor 4-like protein 1Esa1p-associated factor 3 homologMORF-related gene 15 proteinMORF-related gene on chromosome 15protein MSL3-1transcription factor-like protein MRG15serine/threonine-protein kinase DCLK1doublecortin domain-containing protein 3Adoublecortin-like and CAM kinase-like 1
Modification date2020031320200320
UniProtAcc

Q9UBU8

O15075

Ensembl transtripts involved in fusion geneENST00000331268, ENST00000379535, 
ENST00000426013, ENST00000558502, 
ENST00000558746, ENST00000559345, 
ENST00000561171, 		ENST00000255448, 
ENST00000360631, ENST00000379892, 
ENST00000379893, ENST00000460982, 
Fusion gene scores* DoF score9 X 8 X 4=28810 X 9 X 7=630
# samples 1110
** MAII scorelog2(11/288*10)=-1.38856528791765
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MORF4L1 [Title/Abstract] AND DCLK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMORF4L1(79189937)-DCLK1(36376886), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMORF4L1

GO:0000724

double-strand break repair via homologous recombination

20332121

HgeneMORF4L1

GO:0016575

histone deacetylation

14966270

HgeneMORF4L1

GO:0043967

histone H4 acetylation

14966270

HgeneMORF4L1

GO:0043968

histone H2A acetylation

14966270


check buttonFusion gene breakpoints across MORF4L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DCLK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AEC556926MORF4L1chr15

79189937

+DCLK1chr13

36376886

-


Top

Fusion Gene ORF analysis for MORF4L1-DCLK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000331268ENST00000255448MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
3UTR-intronENST00000331268ENST00000360631MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
3UTR-intronENST00000331268ENST00000379892MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
3UTR-intronENST00000331268ENST00000379893MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
3UTR-intronENST00000331268ENST00000460982MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
3UTR-intronENST00000379535ENST00000255448MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
3UTR-intronENST00000379535ENST00000360631MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
3UTR-intronENST00000379535ENST00000379892MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
3UTR-intronENST00000379535ENST00000379893MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
3UTR-intronENST00000379535ENST00000460982MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
3UTR-intronENST00000426013ENST00000255448MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
3UTR-intronENST00000426013ENST00000360631MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
3UTR-intronENST00000426013ENST00000379892MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
3UTR-intronENST00000426013ENST00000379893MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
3UTR-intronENST00000426013ENST00000460982MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000558502ENST00000255448MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000558502ENST00000360631MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000558502ENST00000379892MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000558502ENST00000379893MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000558502ENST00000460982MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000558746ENST00000255448MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000558746ENST00000360631MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000558746ENST00000379892MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000558746ENST00000379893MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000558746ENST00000460982MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000559345ENST00000255448MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000559345ENST00000360631MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000559345ENST00000379892MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000559345ENST00000379893MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000559345ENST00000460982MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000561171ENST00000255448MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000561171ENST00000360631MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000561171ENST00000379892MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000561171ENST00000379893MORF4L1chr15

79189937

+DCLK1chr13

36376886

-
intron-intronENST00000561171ENST00000460982MORF4L1chr15

79189937

+DCLK1chr13

36376886

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for MORF4L1-DCLK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MORF4L1-DCLK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:79189937/:36376886)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MORF4L1

Q9UBU8

DCLK1

O15075

FUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:20332121}.FUNCTION: Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for MORF4L1-DCLK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for MORF4L1-DCLK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MORF4L1-DCLK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MORF4L1-DCLK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource