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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MORF4L2-PAX3 (FusionGDB2 ID:54619)

Fusion Gene Summary for MORF4L2-PAX3

check button Fusion gene summary
Fusion gene informationFusion gene name: MORF4L2-PAX3
Fusion gene ID: 54619
HgeneTgene
Gene symbol

MORF4L2

PAX3

Gene ID

9643

5077

Gene namemortality factor 4 like 2paired box 3
SynonymsMORFL2|MRGXCDHS|HUP2|WS1|WS3
Cytomap

Xq22.2

2q36.1

Type of geneprotein-codingprotein-coding
Descriptionmortality factor 4-like protein 2MORF-related gene X proteinMSL3-2 proteinprotein MSL3-2transcription factor-like protein MRGXpaired box protein Pax-3paired box homeotic gene 3paired domain gene 3paired domain gene HuP2transcriptional factor PAX3
Modification date2020031320200313
UniProtAcc

Q15014

PAXBP1

Ensembl transtripts involved in fusion geneENST00000360458, ENST00000422154, 
ENST00000423833, ENST00000433176, 
ENST00000441076, ENST00000451301, 
ENST00000492116, 		ENST00000258387, 
ENST00000336840, ENST00000344493, 
ENST00000350526, ENST00000392069, 
ENST00000392070, ENST00000409551, 
ENST00000409828, ENST00000464706, 
Fusion gene scores* DoF score8 X 9 X 3=2168 X 11 X 3=264
# samples 89
** MAII scorelog2(8/216*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/264*10)=-1.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MORF4L2 [Title/Abstract] AND PAX3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMORF4L2(102930976)-PAX3(223138945), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePAX3

GO:0045893

positive regulation of transcription, DNA-templated

11863357

TgenePAX3

GO:0045944

positive regulation of transcription by RNA polymerase II

11863357


check buttonFusion gene breakpoints across MORF4L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PAX3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AFN067899MORF4L2chrX

102930976

-PAX3chr2

223138945

-


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Fusion Gene ORF analysis for MORF4L2-PAX3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000360458ENST00000258387MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000360458ENST00000336840MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000360458ENST00000344493MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000360458ENST00000350526MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000360458ENST00000392069MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000360458ENST00000392070MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000360458ENST00000409551MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000360458ENST00000409828MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000360458ENST00000464706MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000422154ENST00000258387MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000422154ENST00000336840MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000422154ENST00000344493MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000422154ENST00000350526MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000422154ENST00000392069MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000422154ENST00000392070MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000422154ENST00000409551MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000422154ENST00000409828MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000422154ENST00000464706MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000423833ENST00000258387MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000423833ENST00000336840MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000423833ENST00000344493MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000423833ENST00000350526MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000423833ENST00000392069MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000423833ENST00000392070MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000423833ENST00000409551MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000423833ENST00000409828MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000423833ENST00000464706MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000433176ENST00000258387MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000433176ENST00000336840MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000433176ENST00000344493MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000433176ENST00000350526MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000433176ENST00000392069MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000433176ENST00000392070MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000433176ENST00000409551MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000433176ENST00000409828MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000433176ENST00000464706MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000441076ENST00000258387MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000441076ENST00000336840MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000441076ENST00000344493MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000441076ENST00000350526MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000441076ENST00000392069MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000441076ENST00000392070MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000441076ENST00000409551MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000441076ENST00000409828MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000441076ENST00000464706MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000451301ENST00000258387MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000451301ENST00000336840MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000451301ENST00000344493MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000451301ENST00000350526MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000451301ENST00000392069MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000451301ENST00000392070MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000451301ENST00000409551MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000451301ENST00000409828MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000451301ENST00000464706MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000492116ENST00000258387MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000492116ENST00000336840MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000492116ENST00000344493MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000492116ENST00000350526MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000492116ENST00000392069MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000492116ENST00000392070MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000492116ENST00000409551MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000492116ENST00000409828MORF4L2chrX

102930976

-PAX3chr2

223138945

-
intron-intronENST00000492116ENST00000464706MORF4L2chrX

102930976

-PAX3chr2

223138945

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MORF4L2-PAX3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MORF4L2-PAX3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:102930976/:223138945)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MORF4L2

Q15014

PAX3

PAXBP1

FUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.917

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MORF4L2-PAX3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MORF4L2-PAX3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MORF4L2-PAX3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MORF4L2-PAX3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource