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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MOSPD2-GPM6B (FusionGDB2 ID:54635)

Fusion Gene Summary for MOSPD2-GPM6B

Fusion gene summary

Fusion gene information	Fusion gene name: MOSPD2-GPM6B
	Fusion gene ID: 54635
		Hgene	Tgene
	Gene symbol	MOSPD2	GPM6B
	Gene ID	158747	2824
	Gene name	motile sperm domain containing 2	glycoprotein M6B
	Synonyms	-	M6B
	Cytomap	Xp22.2	Xp22.2
	Type of gene	protein-coding	protein-coding
	Description	motile sperm domain-containing protein 2	neuronal membrane glycoprotein M6-bprotolipid M6B
	Modification date	20200313	20200313
	UniProtAcc	.	Q13491
	Ensembl transtripts involved in fusion gene	ENST00000380492, ENST00000482354, ENST00000497603, ENST00000495110,	ENST00000316715, ENST00000355135, ENST00000356942, ENST00000398361, ENST00000493677, ENST00000454189,
Fusion gene scores	* DoF score	7 X 2 X 5=70	11 X 12 X 4=528
	# samples	7	14
	** MAII score	log2(7/70*10)=0	log2(14/528*10)=-1.91511110241349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MOSPD2 [Title/Abstract] AND GPM6B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MOSPD2(14891880)-GPM6B(13803927), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MOSPD2	GO:0090023	positive regulation of neutrophil chemotaxis	28137892
Hgene	MOSPD2	GO:0090026	positive regulation of monocyte chemotaxis	28137892

Fusion gene breakpoints across MOSPD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GPM6B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-14-1823-01A	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-

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Fusion Gene ORF analysis for MOSPD2-GPM6B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000380492	ENST00000316715	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
5CDS-5UTR	ENST00000380492	ENST00000355135	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
5CDS-5UTR	ENST00000380492	ENST00000356942	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
5CDS-5UTR	ENST00000380492	ENST00000398361	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
5CDS-5UTR	ENST00000380492	ENST00000493677	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
5CDS-5UTR	ENST00000482354	ENST00000316715	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
5CDS-5UTR	ENST00000482354	ENST00000355135	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
5CDS-5UTR	ENST00000482354	ENST00000356942	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
5CDS-5UTR	ENST00000482354	ENST00000398361	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
5CDS-5UTR	ENST00000482354	ENST00000493677	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
5CDS-5UTR	ENST00000497603	ENST00000316715	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
5CDS-5UTR	ENST00000497603	ENST00000355135	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
5CDS-5UTR	ENST00000497603	ENST00000356942	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
5CDS-5UTR	ENST00000497603	ENST00000398361	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
5CDS-5UTR	ENST00000497603	ENST00000493677	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
In-frame	ENST00000380492	ENST00000454189	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
In-frame	ENST00000482354	ENST00000454189	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
In-frame	ENST00000497603	ENST00000454189	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
intron-3CDS	ENST00000495110	ENST00000454189	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
intron-5UTR	ENST00000495110	ENST00000316715	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
intron-5UTR	ENST00000495110	ENST00000355135	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
intron-5UTR	ENST00000495110	ENST00000356942	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
intron-5UTR	ENST00000495110	ENST00000398361	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-
intron-5UTR	ENST00000495110	ENST00000493677	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000380492	MOSPD2	chrX	14891880	+	ENST00000454189	GPM6B	chrX	13803927	-	3992	167	88	903	271
ENST00000482354	MOSPD2	chrX	14891880	+	ENST00000454189	GPM6B	chrX	13803927	-	3978	153	74	889	271
ENST00000497603	MOSPD2	chrX	14891880	+	ENST00000454189	GPM6B	chrX	13803927	-	4530	705	695	1441	248

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000380492	ENST00000454189	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-	0.001097848	0.9989021
ENST00000482354	ENST00000454189	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-	0.001098026	0.99890196
ENST00000497603	ENST00000454189	MOSPD2	chrX	14891880	+	GPM6B	chrX	13803927	-	0.00144959	0.99855036

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Fusion Genomic Features for MOSPD2-GPM6B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MOSPD2-GPM6B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:14891880/chrX:13803927)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	GPM6B Q13491
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. {ECO:0000269\|PubMed:21638316}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GPM6B

chrX:14891880

chrX:13803927

ENST00000316715

136_156

329.0

Transmembrane

Helical

Tgene

GPM6B

chrX:14891880

chrX:13803927

ENST00000316715

224_244

329.0

Transmembrane

Helical

Tgene

GPM6B

chrX:14891880

chrX:13803927

ENST00000316715

90_110

329.0

Transmembrane

Helical

Tgene

GPM6B

chrX:14891880

chrX:13803927

ENST00000355135

136_156

306.0

Transmembrane

Helical

Tgene

GPM6B

chrX:14891880

chrX:13803927

ENST00000355135

224_244

306.0

Transmembrane

Helical

Tgene

GPM6B

chrX:14891880

chrX:13803927

ENST00000355135

90_110

306.0

Transmembrane

Helical

Tgene

GPM6B

chrX:14891880

chrX:13803927

ENST00000356942

136_156

266.0

Transmembrane

Helical

Tgene

GPM6B

chrX:14891880

chrX:13803927

ENST00000356942

224_244

266.0

Transmembrane

Helical

Tgene

GPM6B

chrX:14891880

chrX:13803927

ENST00000356942

31_51

266.0

Transmembrane

Helical

Tgene

GPM6B

chrX:14891880

chrX:13803927

ENST00000356942

90_110

266.0

Transmembrane

Helical

Tgene

GPM6B

chrX:14891880

chrX:13803927

ENST00000454189

136_156

247.0

Transmembrane

Helical

Tgene

GPM6B

chrX:14891880

chrX:13803927

ENST00000454189

224_244

247.0

Transmembrane

Helical

Tgene

GPM6B

chrX:14891880

chrX:13803927

ENST00000454189

31_51

247.0

Transmembrane

Helical

Tgene

GPM6B

chrX:14891880

chrX:13803927

ENST00000454189

90_110

247.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MOSPD2

chrX:14891880

chrX:13803927

ENST00000380492

327_445

519.0

Domain

MSP

Hgene

MOSPD2

chrX:14891880

chrX:13803927

ENST00000380492

82_239

519.0

Domain

CRAL-TRIO

Hgene

MOSPD2

chrX:14891880

chrX:13803927

ENST00000380492

1_496

519.0

Topological domain

Cytoplasmic

Hgene

MOSPD2

chrX:14891880

chrX:13803927

ENST00000380492

497_518

519.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Tgene

GPM6B

chrX:14891880

chrX:13803927

ENST00000316715

31_51

329.0

Transmembrane

Helical

Tgene

GPM6B

chrX:14891880

chrX:13803927

ENST00000355135

31_51

306.0

Transmembrane

Helical

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Fusion Gene Sequence for MOSPD2-GPM6B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>54635_54635_1_MOSPD2-GPM6B_MOSPD2_chrX_14891880_ENST00000380492_GPM6B_chrX_13803927_ENST00000454189_length(transcript)=3992nt_BP=167nt
GGGCGGGACTGCCGGGTGATGAGATACTCGGTCGGCGACGGTAGAACGGGCGACGGCGACAACCGCAATCACATCCACGACGGTGATCAT
GGCAGAGAATCACGCCCAGAATAAAGCCAAGCTCATCTCTGAGACCCGGAGGAGGTTCGAAGCTGAGTATGTGACAGGCTGCTTTGAATG
CTGCATCAAGTGTCTGGGAGGAGTCCCCTACGCCTCCCTGGTGGCCACCATCCTCTGCTTCTCCGGGGTGGCCTTATTCTGCGGCTGTGG
GCATGTGGCTCTCGCAGGCACCGTGGCGATTCTTGAGCAACACTTCTCCACCAACGCCAGTGACCATGCCTTGCTGAGCGAGGTGATACA
ACTGATGCAGTATGTCATCTATGGAATTGCGTCCTTTTTCTTCTTGTATGGGATCATTCTGTTGGCAGAAGGCTTTTACACCACAAGTGC
AGTGAAAGAACTGCACGGTGAGTTTAAAACAACCGCTTGTGGCCGATGCATCAGTGGAATGTTCGTTTTCCTCACCTATGTGCTTGGAGT
GGCCTGGCTGGGTGTGTTTGGTTTCTCAGCGGTGCCCGTGTTTATGTTCTACAACATATGGTCAACTTGTGAAGTCATCAAGTCACCGCA
GACCAACGGGACCACGGGTGTGGAGCAGATCTGTGTGGATATCCGACAATACGGTATCATTCCTTGGAATGCTTTCCCCGGAAAAATATG
TGGCTCTGCCCTGGAGAACATCTGCAACACAAACGAGTTCTACATGTCCTATCACCTGTTCATTGTGGCCTGTGCAGGAGCTGGTGCCAC
CGTCATTGCCCTGCTGATCTACATGATGGCTACTACATATAACTATGCGGTTTTGAAGTTTAAGAGTCGGGAAGATTGCTGCACTAAATT
CTAAATTGCATAAGGAGTTTTAGAGAGCTATGCTCTGTAGCATGAAATATCACTGACACTCCAGACTAAAGCAGAGTCTAGGTTTCTGCA
ATTTTGTTACAGTAATTTGTAAATAGCTTTAGTAAACTCACCTTGCATGGTAGATTAATAAGATGACTTACTGTACATGAATTACACAAT
AATGAGATCTGGTGGCTATTTCCACATTTTGAAAAGGATTCAGTTATTTACTGACAGTGGTGAGCATCCTTTTTAAAATAATGTTCTCAT
ACTTAAACATTAGAGAGCAGTATCTTTAAATGAATTATTAACACTTTGGAATACTTACATTTTCTGTTATTTTTGATTGCCTGATAACCA
GTTTCAATGATGAAAATGAAAACAAGTGCTGAAGATGAAATGGAAGAGAACCGTTTTAATCTGGATTTTGTTTTGTCACACCTGGAAAAT
ACTTTGCAAATATGTTCTAAATTGAAAACAATTTTTTTATGATCACATGGTTCACTACCAAATGACCCTCAAATAAGCCAGATGAAAATT
TGAAGAAAAAGGTCACCCAGTTCTCTGGAAAAAAAAAAAAAAAAAAAAAAAAAAGGATTTATATGTGGGTAGTTTTTTTTTTGGTACAAC
ACAATCATTCTGTTAGAGCCCACAAAATTGGTAACCTTAAATTGTGTGTTTTGGTAAGTAATAACTAACTGTTTCCTCATAGCTAGTTCT
CAAGCTGCATGTAAGATTTTAACGGGAAGAGAAAATAGGCCTGGACCTGAAGGTCTCAAATATGTTGAGAAGAAAGTATGAACTATAAGG
AACTTGAGATGTAGATTTATTTTGCAGGAAATACGAGGAAAATAGGAAAGAAGTGTTTGCCGCATCAAGTGTAAAGAATGATACTGAGGA
TTTTTACATTTTATGAAATGAAATAATGGCATTTACAAAATGAAAAATGTAGTTTCACAACTAAGTTTTGTTAACAGAGACTGCATGCTT
TGCTTATAGTTCTTAATTTTGGTTTTGACATTCATTTAATTTTTTCCATGTTAAATATGTAGTTTAATTATTTACTCAAAATAAACATTG
TTCATGCTTTTAGGCCTTTGGGGGAATTGATTTTTATCCACAGGTAGAAAATGGTCTTTGCACACACTACACTTATTTCAAATATACAAT
GTGCTCCCGAACTTTCGCATTAGTCTTTAAAATTACTCTCAAAATGGTATTAAAAAAAAAAAAAAAAGCACCCTCTCGTATTTCATTTTT
GCTTTTTCTTAACAATACCTTTGGCCATTTTTTTCCAGTTCACTATGTTTGTATACTAACTTTTCTTCAGCCTTTTAATGCGAAGCCAAC
TAGTAGAGCATGCTTTCAGGATCTGACAGCTCTGCTAGTAGAGCGAGTATTTATTAATACAGAATTAACCTTCGCCCCTTTAAAGTCAAG
TCTGTCTAATCTAACTAGCGCCTCGCTTTGCCTTCTCACAATGCTCACTAGCCATCATGCTCACCCTTCTCTTCCAGATCCACTTCCTCA
TGATACTGTCTTCTAACTGGGCTTACTTAAAGGATGCGAGCAAAATGCAGGCTTACCAGGATATCAAAGCAAAGGAAGAACAGGAACTGC
AAGATATCCAGTCTCGGTCAAAAGAACAACTCAATTCTTACACATAAATGTTTGCCAGAGTGTTTCGGCCGACGTATTTACAGCTCTGAC
AAATCATCAGACAGCTGCTCTGCAGTACAGATGTGTATCCCACCAAACTAATGTAGATGTACAAACACTTCACTGTCTGTCTCAAGCTGC
TGGGATGTATCTCTAGGAAAACCTTCCAGTGGGTAAATCTTTTTCTTTAGAACAAATATTGGAGGTTTCATGTTAGCCATTTTAAAAGGC
AACACTTTGACAAAATGATCGTTCATACTTTGGGAATTTGTGGCATGTTCACATTTATTGCTAGGGCAATTCTACCAAGACACTCAATGG
AATATGTCACACTCCTTAATAGGGACCTGTGACTCCTTAATAAGGACCTGTGACATGCCCAGCATCAAGGGATAAGACCGTAAATTCACA
TATATGCCATCTGTCCTCAAGTGTTATCTACATAGGAAATAAAATGGAATTGATGTAAAGTTCCATTTCTGACAGCTGACATTTATTAAA
CTTTGGATCAAAGATAATGTGATTCTTATGATTGATTTCTCAAACTAGCTTTTCCCTCCCAAGTCCAGGACCCATTAATTTCCTGAGCCA
ATCAGAAATATATTTTTCAATAATGCTAAAATTAGCTACAATTCTGCTGACCCTACTATTAAAGAATCTGGATGCTGGACTCACTGACAA
GCTTTCCAGAAGCAATTTTATAACAGATTTCATTTTAACAAAATACTGATCCAATTTTCATTATTCTTGAGAAATGTCAGCTTTGCCTTA
ATGAGTATTTGCTTTAAATTTCTAAGAATTTATATCATAACTAGAGACCCAAATATCTTTCACAGAATTTTGTTCCATAAATGTTTTTCT
TAATTATTAAGAAGTGTTACCTTATTAAAATGACCACCATTCTAAACCATTTTTCAGTGGTCTGGATACGAAGTTTACAGTTTCATACCA
ACTATCTAAAACCTAATTGCAAATTGACCACAGACCTCTAACCTCCTACTTTTATAGACTTGAATACTTAAGTAATTTAAATTAGGGTTG
GTATTTCATTTTTTTCTTATCTAAATCTTAGTTTCCTGGAATAATAAAGTTTGATGTTCAGCAAGAGAACTGCTTGAGTTTAAGCCATTT
TCAAAAGAAACTTGCCTTTTACATTATTGTGTTCCAGAACATTAAGTGACTGTAGGTACTGGGTATTAGTGATGGTAAACTTTGTGTTGC
TCTTTATGAAATGATCCATATAACTGTTGGGTGCATCAGTGCTTTTCAAAGGGGCTGCTTACTATAGGGTTAACTATGTATATTCATTGT
TAAGAGTTAACTTGTGGTTTGGCTGTTTCCTGGATTTTATAACATACATGTGCAGAAATGTATTCAAATGAAAGGAAGCATACCTTTATC

>54635_54635_1_MOSPD2-GPM6B_MOSPD2_chrX_14891880_ENST00000380492_GPM6B_chrX_13803927_ENST00000454189_length(amino acids)=271AA_BP=26
MAENHAQNKAKLISETRRRFEAEYVTGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNASDHALLSEVI
QLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSP
QTNGTTGVEQICVDIRQYGIIPWNAFPGKICGSALENICNTNEFYMSYHLFIVACAGAGATVIALLIYMMATTYNYAVLKFKSREDCCTK

--------------------------------------------------------------
>54635_54635_2_MOSPD2-GPM6B_MOSPD2_chrX_14891880_ENST00000482354_GPM6B_chrX_13803927_ENST00000454189_length(transcript)=3978nt_BP=153nt
GGTGATGAGATACTCGGTCGGCGACGGTAGAACGGGCGACGGCGACAACCGCAATCACATCCACGACGGTGATCATGGCAGAGAATCACG
CCCAGAATAAAGCCAAGCTCATCTCTGAGACCCGGAGGAGGTTCGAAGCTGAGTATGTGACAGGCTGCTTTGAATGCTGCATCAAGTGTC
TGGGAGGAGTCCCCTACGCCTCCCTGGTGGCCACCATCCTCTGCTTCTCCGGGGTGGCCTTATTCTGCGGCTGTGGGCATGTGGCTCTCG
CAGGCACCGTGGCGATTCTTGAGCAACACTTCTCCACCAACGCCAGTGACCATGCCTTGCTGAGCGAGGTGATACAACTGATGCAGTATG
TCATCTATGGAATTGCGTCCTTTTTCTTCTTGTATGGGATCATTCTGTTGGCAGAAGGCTTTTACACCACAAGTGCAGTGAAAGAACTGC
ACGGTGAGTTTAAAACAACCGCTTGTGGCCGATGCATCAGTGGAATGTTCGTTTTCCTCACCTATGTGCTTGGAGTGGCCTGGCTGGGTG
TGTTTGGTTTCTCAGCGGTGCCCGTGTTTATGTTCTACAACATATGGTCAACTTGTGAAGTCATCAAGTCACCGCAGACCAACGGGACCA
CGGGTGTGGAGCAGATCTGTGTGGATATCCGACAATACGGTATCATTCCTTGGAATGCTTTCCCCGGAAAAATATGTGGCTCTGCCCTGG
AGAACATCTGCAACACAAACGAGTTCTACATGTCCTATCACCTGTTCATTGTGGCCTGTGCAGGAGCTGGTGCCACCGTCATTGCCCTGC
TGATCTACATGATGGCTACTACATATAACTATGCGGTTTTGAAGTTTAAGAGTCGGGAAGATTGCTGCACTAAATTCTAAATTGCATAAG
GAGTTTTAGAGAGCTATGCTCTGTAGCATGAAATATCACTGACACTCCAGACTAAAGCAGAGTCTAGGTTTCTGCAATTTTGTTACAGTA
ATTTGTAAATAGCTTTAGTAAACTCACCTTGCATGGTAGATTAATAAGATGACTTACTGTACATGAATTACACAATAATGAGATCTGGTG
GCTATTTCCACATTTTGAAAAGGATTCAGTTATTTACTGACAGTGGTGAGCATCCTTTTTAAAATAATGTTCTCATACTTAAACATTAGA
GAGCAGTATCTTTAAATGAATTATTAACACTTTGGAATACTTACATTTTCTGTTATTTTTGATTGCCTGATAACCAGTTTCAATGATGAA
AATGAAAACAAGTGCTGAAGATGAAATGGAAGAGAACCGTTTTAATCTGGATTTTGTTTTGTCACACCTGGAAAATACTTTGCAAATATG
TTCTAAATTGAAAACAATTTTTTTATGATCACATGGTTCACTACCAAATGACCCTCAAATAAGCCAGATGAAAATTTGAAGAAAAAGGTC
ACCCAGTTCTCTGGAAAAAAAAAAAAAAAAAAAAAAAAAAGGATTTATATGTGGGTAGTTTTTTTTTTGGTACAACACAATCATTCTGTT
AGAGCCCACAAAATTGGTAACCTTAAATTGTGTGTTTTGGTAAGTAATAACTAACTGTTTCCTCATAGCTAGTTCTCAAGCTGCATGTAA
GATTTTAACGGGAAGAGAAAATAGGCCTGGACCTGAAGGTCTCAAATATGTTGAGAAGAAAGTATGAACTATAAGGAACTTGAGATGTAG
ATTTATTTTGCAGGAAATACGAGGAAAATAGGAAAGAAGTGTTTGCCGCATCAAGTGTAAAGAATGATACTGAGGATTTTTACATTTTAT
GAAATGAAATAATGGCATTTACAAAATGAAAAATGTAGTTTCACAACTAAGTTTTGTTAACAGAGACTGCATGCTTTGCTTATAGTTCTT
AATTTTGGTTTTGACATTCATTTAATTTTTTCCATGTTAAATATGTAGTTTAATTATTTACTCAAAATAAACATTGTTCATGCTTTTAGG
CCTTTGGGGGAATTGATTTTTATCCACAGGTAGAAAATGGTCTTTGCACACACTACACTTATTTCAAATATACAATGTGCTCCCGAACTT
TCGCATTAGTCTTTAAAATTACTCTCAAAATGGTATTAAAAAAAAAAAAAAAAGCACCCTCTCGTATTTCATTTTTGCTTTTTCTTAACA
ATACCTTTGGCCATTTTTTTCCAGTTCACTATGTTTGTATACTAACTTTTCTTCAGCCTTTTAATGCGAAGCCAACTAGTAGAGCATGCT
TTCAGGATCTGACAGCTCTGCTAGTAGAGCGAGTATTTATTAATACAGAATTAACCTTCGCCCCTTTAAAGTCAAGTCTGTCTAATCTAA
CTAGCGCCTCGCTTTGCCTTCTCACAATGCTCACTAGCCATCATGCTCACCCTTCTCTTCCAGATCCACTTCCTCATGATACTGTCTTCT
AACTGGGCTTACTTAAAGGATGCGAGCAAAATGCAGGCTTACCAGGATATCAAAGCAAAGGAAGAACAGGAACTGCAAGATATCCAGTCT
CGGTCAAAAGAACAACTCAATTCTTACACATAAATGTTTGCCAGAGTGTTTCGGCCGACGTATTTACAGCTCTGACAAATCATCAGACAG
CTGCTCTGCAGTACAGATGTGTATCCCACCAAACTAATGTAGATGTACAAACACTTCACTGTCTGTCTCAAGCTGCTGGGATGTATCTCT
AGGAAAACCTTCCAGTGGGTAAATCTTTTTCTTTAGAACAAATATTGGAGGTTTCATGTTAGCCATTTTAAAAGGCAACACTTTGACAAA
ATGATCGTTCATACTTTGGGAATTTGTGGCATGTTCACATTTATTGCTAGGGCAATTCTACCAAGACACTCAATGGAATATGTCACACTC
CTTAATAGGGACCTGTGACTCCTTAATAAGGACCTGTGACATGCCCAGCATCAAGGGATAAGACCGTAAATTCACATATATGCCATCTGT
CCTCAAGTGTTATCTACATAGGAAATAAAATGGAATTGATGTAAAGTTCCATTTCTGACAGCTGACATTTATTAAACTTTGGATCAAAGA
TAATGTGATTCTTATGATTGATTTCTCAAACTAGCTTTTCCCTCCCAAGTCCAGGACCCATTAATTTCCTGAGCCAATCAGAAATATATT
TTTCAATAATGCTAAAATTAGCTACAATTCTGCTGACCCTACTATTAAAGAATCTGGATGCTGGACTCACTGACAAGCTTTCCAGAAGCA
ATTTTATAACAGATTTCATTTTAACAAAATACTGATCCAATTTTCATTATTCTTGAGAAATGTCAGCTTTGCCTTAATGAGTATTTGCTT
TAAATTTCTAAGAATTTATATCATAACTAGAGACCCAAATATCTTTCACAGAATTTTGTTCCATAAATGTTTTTCTTAATTATTAAGAAG
TGTTACCTTATTAAAATGACCACCATTCTAAACCATTTTTCAGTGGTCTGGATACGAAGTTTACAGTTTCATACCAACTATCTAAAACCT
AATTGCAAATTGACCACAGACCTCTAACCTCCTACTTTTATAGACTTGAATACTTAAGTAATTTAAATTAGGGTTGGTATTTCATTTTTT
TCTTATCTAAATCTTAGTTTCCTGGAATAATAAAGTTTGATGTTCAGCAAGAGAACTGCTTGAGTTTAAGCCATTTTCAAAAGAAACTTG
CCTTTTACATTATTGTGTTCCAGAACATTAAGTGACTGTAGGTACTGGGTATTAGTGATGGTAAACTTTGTGTTGCTCTTTATGAAATGA
TCCATATAACTGTTGGGTGCATCAGTGCTTTTCAAAGGGGCTGCTTACTATAGGGTTAACTATGTATATTCATTGTTAAGAGTTAACTTG
TGGTTTGGCTGTTTCCTGGATTTTATAACATACATGTGCAGAAATGTATTCAAATGAAAGGAAGCATACCTTTATCAAGATGCTATTAAA

>54635_54635_2_MOSPD2-GPM6B_MOSPD2_chrX_14891880_ENST00000482354_GPM6B_chrX_13803927_ENST00000454189_length(amino acids)=271AA_BP=26
MAENHAQNKAKLISETRRRFEAEYVTGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNASDHALLSEVI
QLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSP
QTNGTTGVEQICVDIRQYGIIPWNAFPGKICGSALENICNTNEFYMSYHLFIVACAGAGATVIALLIYMMATTYNYAVLKFKSREDCCTK

--------------------------------------------------------------
>54635_54635_3_MOSPD2-GPM6B_MOSPD2_chrX_14891880_ENST00000497603_GPM6B_chrX_13803927_ENST00000454189_length(transcript)=4530nt_BP=705nt
ATGGCAGAGGTGGGTACTCTGTTCCAGGTATTAAGAAAGGTGTGCAGTGAGCATCCCCAACTTTGCTGGAGTGTTTGTGAGTGTATTTGT
GGGAGGTGTTAGGGACCCTTTCGACCCTCACAGGAATGATGCTGGGCACGTCTCAAAGGTTTTCCTCTCCATGACAAGCCGTGTGCACTG
CTTCAAATGGTCAAGTGGTGTGTCCCATGCTCCCTTTAAAGGGTTAATGTAAGTTGGAAATCGGTTAAGTTTTTAGCATGCCCTCGTGTT
TATGGAACTTGCAGGATACTTGTTAGGCCCACAACACGGGTGACATTGTCCAGTCCACGGTTCCACTGCTGGCCTTTCACCAGCAACACT
AGCGAAAATGTACCTGGAAACTGCCATAATACTATTGATGTGTACTTAATTGGGTATACAAATTCCTTGGATATTTTGTTTGATTTGGCT
TTCATACAACCCAGCATGCTACCCACAAAATAGGCCCTCCAATGCTGGAACAAGTTCTTATCCCAAACTGTATCTTGCAAAGTACCTATG
AGTCCAGAATTGATTTATTGGTTGAACATTCTGTGTCCAGATGTCACAGATACTTGAGTTGTCAGGTACTTAACTGAATATTTAATGCTT
GTACAGTAATTTTGTAAAACATACGGAATAACTTATTGTAAATATGGAATTAAATAAGGATTTATATGTTGCCTAGCTGCTTTGAATGCT
GCATCAAGTGTCTGGGAGGAGTCCCCTACGCCTCCCTGGTGGCCACCATCCTCTGCTTCTCCGGGGTGGCCTTATTCTGCGGCTGTGGGC
ATGTGGCTCTCGCAGGCACCGTGGCGATTCTTGAGCAACACTTCTCCACCAACGCCAGTGACCATGCCTTGCTGAGCGAGGTGATACAAC
TGATGCAGTATGTCATCTATGGAATTGCGTCCTTTTTCTTCTTGTATGGGATCATTCTGTTGGCAGAAGGCTTTTACACCACAAGTGCAG
TGAAAGAACTGCACGGTGAGTTTAAAACAACCGCTTGTGGCCGATGCATCAGTGGAATGTTCGTTTTCCTCACCTATGTGCTTGGAGTGG
CCTGGCTGGGTGTGTTTGGTTTCTCAGCGGTGCCCGTGTTTATGTTCTACAACATATGGTCAACTTGTGAAGTCATCAAGTCACCGCAGA
CCAACGGGACCACGGGTGTGGAGCAGATCTGTGTGGATATCCGACAATACGGTATCATTCCTTGGAATGCTTTCCCCGGAAAAATATGTG
GCTCTGCCCTGGAGAACATCTGCAACACAAACGAGTTCTACATGTCCTATCACCTGTTCATTGTGGCCTGTGCAGGAGCTGGTGCCACCG
TCATTGCCCTGCTGATCTACATGATGGCTACTACATATAACTATGCGGTTTTGAAGTTTAAGAGTCGGGAAGATTGCTGCACTAAATTCT
AAATTGCATAAGGAGTTTTAGAGAGCTATGCTCTGTAGCATGAAATATCACTGACACTCCAGACTAAAGCAGAGTCTAGGTTTCTGCAAT
TTTGTTACAGTAATTTGTAAATAGCTTTAGTAAACTCACCTTGCATGGTAGATTAATAAGATGACTTACTGTACATGAATTACACAATAA
TGAGATCTGGTGGCTATTTCCACATTTTGAAAAGGATTCAGTTATTTACTGACAGTGGTGAGCATCCTTTTTAAAATAATGTTCTCATAC
TTAAACATTAGAGAGCAGTATCTTTAAATGAATTATTAACACTTTGGAATACTTACATTTTCTGTTATTTTTGATTGCCTGATAACCAGT
TTCAATGATGAAAATGAAAACAAGTGCTGAAGATGAAATGGAAGAGAACCGTTTTAATCTGGATTTTGTTTTGTCACACCTGGAAAATAC
TTTGCAAATATGTTCTAAATTGAAAACAATTTTTTTATGATCACATGGTTCACTACCAAATGACCCTCAAATAAGCCAGATGAAAATTTG
AAGAAAAAGGTCACCCAGTTCTCTGGAAAAAAAAAAAAAAAAAAAAAAAAAAGGATTTATATGTGGGTAGTTTTTTTTTTGGTACAACAC
AATCATTCTGTTAGAGCCCACAAAATTGGTAACCTTAAATTGTGTGTTTTGGTAAGTAATAACTAACTGTTTCCTCATAGCTAGTTCTCA
AGCTGCATGTAAGATTTTAACGGGAAGAGAAAATAGGCCTGGACCTGAAGGTCTCAAATATGTTGAGAAGAAAGTATGAACTATAAGGAA
CTTGAGATGTAGATTTATTTTGCAGGAAATACGAGGAAAATAGGAAAGAAGTGTTTGCCGCATCAAGTGTAAAGAATGATACTGAGGATT
TTTACATTTTATGAAATGAAATAATGGCATTTACAAAATGAAAAATGTAGTTTCACAACTAAGTTTTGTTAACAGAGACTGCATGCTTTG
CTTATAGTTCTTAATTTTGGTTTTGACATTCATTTAATTTTTTCCATGTTAAATATGTAGTTTAATTATTTACTCAAAATAAACATTGTT
CATGCTTTTAGGCCTTTGGGGGAATTGATTTTTATCCACAGGTAGAAAATGGTCTTTGCACACACTACACTTATTTCAAATATACAATGT
GCTCCCGAACTTTCGCATTAGTCTTTAAAATTACTCTCAAAATGGTATTAAAAAAAAAAAAAAAAGCACCCTCTCGTATTTCATTTTTGC
TTTTTCTTAACAATACCTTTGGCCATTTTTTTCCAGTTCACTATGTTTGTATACTAACTTTTCTTCAGCCTTTTAATGCGAAGCCAACTA
GTAGAGCATGCTTTCAGGATCTGACAGCTCTGCTAGTAGAGCGAGTATTTATTAATACAGAATTAACCTTCGCCCCTTTAAAGTCAAGTC
TGTCTAATCTAACTAGCGCCTCGCTTTGCCTTCTCACAATGCTCACTAGCCATCATGCTCACCCTTCTCTTCCAGATCCACTTCCTCATG
ATACTGTCTTCTAACTGGGCTTACTTAAAGGATGCGAGCAAAATGCAGGCTTACCAGGATATCAAAGCAAAGGAAGAACAGGAACTGCAA
GATATCCAGTCTCGGTCAAAAGAACAACTCAATTCTTACACATAAATGTTTGCCAGAGTGTTTCGGCCGACGTATTTACAGCTCTGACAA
ATCATCAGACAGCTGCTCTGCAGTACAGATGTGTATCCCACCAAACTAATGTAGATGTACAAACACTTCACTGTCTGTCTCAAGCTGCTG
GGATGTATCTCTAGGAAAACCTTCCAGTGGGTAAATCTTTTTCTTTAGAACAAATATTGGAGGTTTCATGTTAGCCATTTTAAAAGGCAA
CACTTTGACAAAATGATCGTTCATACTTTGGGAATTTGTGGCATGTTCACATTTATTGCTAGGGCAATTCTACCAAGACACTCAATGGAA
TATGTCACACTCCTTAATAGGGACCTGTGACTCCTTAATAAGGACCTGTGACATGCCCAGCATCAAGGGATAAGACCGTAAATTCACATA
TATGCCATCTGTCCTCAAGTGTTATCTACATAGGAAATAAAATGGAATTGATGTAAAGTTCCATTTCTGACAGCTGACATTTATTAAACT
TTGGATCAAAGATAATGTGATTCTTATGATTGATTTCTCAAACTAGCTTTTCCCTCCCAAGTCCAGGACCCATTAATTTCCTGAGCCAAT
CAGAAATATATTTTTCAATAATGCTAAAATTAGCTACAATTCTGCTGACCCTACTATTAAAGAATCTGGATGCTGGACTCACTGACAAGC
TTTCCAGAAGCAATTTTATAACAGATTTCATTTTAACAAAATACTGATCCAATTTTCATTATTCTTGAGAAATGTCAGCTTTGCCTTAAT
GAGTATTTGCTTTAAATTTCTAAGAATTTATATCATAACTAGAGACCCAAATATCTTTCACAGAATTTTGTTCCATAAATGTTTTTCTTA
ATTATTAAGAAGTGTTACCTTATTAAAATGACCACCATTCTAAACCATTTTTCAGTGGTCTGGATACGAAGTTTACAGTTTCATACCAAC
TATCTAAAACCTAATTGCAAATTGACCACAGACCTCTAACCTCCTACTTTTATAGACTTGAATACTTAAGTAATTTAAATTAGGGTTGGT
ATTTCATTTTTTTCTTATCTAAATCTTAGTTTCCTGGAATAATAAAGTTTGATGTTCAGCAAGAGAACTGCTTGAGTTTAAGCCATTTTC
AAAAGAAACTTGCCTTTTACATTATTGTGTTCCAGAACATTAAGTGACTGTAGGTACTGGGTATTAGTGATGGTAAACTTTGTGTTGCTC
TTTATGAAATGATCCATATAACTGTTGGGTGCATCAGTGCTTTTCAAAGGGGCTGCTTACTATAGGGTTAACTATGTATATTCATTGTTA
AGAGTTAACTTGTGGTTTGGCTGTTTCCTGGATTTTATAACATACATGTGCAGAAATGTATTCAAATGAAAGGAAGCATACCTTTATCAA

>54635_54635_3_MOSPD2-GPM6B_MOSPD2_chrX_14891880_ENST00000497603_GPM6B_chrX_13803927_ENST00000454189_length(amino acids)=248AA_BP=4
MLPSCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNASDHALLSEVIQLMQYVIYGIASFFFLYGIILLA
EGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQTNGTTGVEQICVDIRQYGIIPW

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MOSPD2-GPM6B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MOSPD2-GPM6B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MOSPD2-GPM6B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source