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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MPC2-DNM3 (FusionGDB2 ID:54656)

Fusion Gene Summary for MPC2-DNM3

Fusion gene summary

Fusion gene information	Fusion gene name: MPC2-DNM3
	Fusion gene ID: 54656
		Hgene	Tgene
	Gene symbol	MPC2	DNM3
	Gene ID	25874	26052
	Gene name	mitochondrial pyruvate carrier 2	dynamin 3
	Synonyms	BRP44\|SLC54A2	Dyna III
	Cytomap	1q24.2	1q24.3
	Type of gene	protein-coding	protein-coding
	Description	mitochondrial pyruvate carrier 2brain protein 44	dynamin-3T-dynamindynamin family memberdynamin, testicular
	Modification date	20200313	20200313
	UniProtAcc	O95563	Q9UQ16
	Ensembl transtripts involved in fusion gene	ENST00000271373, ENST00000367846,	ENST00000355305, ENST00000367731, ENST00000367733, ENST00000520906, ENST00000358155,
Fusion gene scores	* DoF score	4 X 3 X 2=24	19 X 17 X 5=1615
	# samples	4	21
	** MAII score	log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(21/1615*10)=-2.94307293191516 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MPC2 [Title/Abstract] AND DNM3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MPC2(167904971)-DNM3(172356273), # samples:2
Anticipated loss of major functional domain due to fusion event.	MPC2-DNM3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MPC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DNM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A6BG-01A	MPC2	chr1	167904971	-	DNM3	chr1	172356273	+
ChimerDB4	SARC	TCGA-DX-A7ES-01A	MPC2	chr1	167904971	-	DNM3	chr1	172356273	+

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Fusion Gene ORF analysis for MPC2-DNM3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000271373	ENST00000355305	MPC2	chr1	167904971	-	DNM3	chr1	172356273	+
5CDS-intron	ENST00000271373	ENST00000367731	MPC2	chr1	167904971	-	DNM3	chr1	172356273	+
5CDS-intron	ENST00000271373	ENST00000367733	MPC2	chr1	167904971	-	DNM3	chr1	172356273	+
5CDS-intron	ENST00000271373	ENST00000520906	MPC2	chr1	167904971	-	DNM3	chr1	172356273	+
5CDS-intron	ENST00000367846	ENST00000355305	MPC2	chr1	167904971	-	DNM3	chr1	172356273	+
5CDS-intron	ENST00000367846	ENST00000367731	MPC2	chr1	167904971	-	DNM3	chr1	172356273	+
5CDS-intron	ENST00000367846	ENST00000367733	MPC2	chr1	167904971	-	DNM3	chr1	172356273	+
5CDS-intron	ENST00000367846	ENST00000520906	MPC2	chr1	167904971	-	DNM3	chr1	172356273	+
Frame-shift	ENST00000271373	ENST00000358155	MPC2	chr1	167904971	-	DNM3	chr1	172356273	+
In-frame	ENST00000367846	ENST00000358155	MPC2	chr1	167904971	-	DNM3	chr1	172356273	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000367846

MPC2

chr1

167904971

ENST00000358155

DNM3

chr1

172356273

5717

308

344

841

165

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367846	ENST00000358155	MPC2	chr1	167904971	-	DNM3	chr1	172356273	+	0.25140613	0.74859387

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Fusion Genomic Features for MPC2-DNM3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MPC2-DNM3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:167904971/chr1:172356273)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MPC2 O95563	DNM3 Q9UQ16
FUNCTION: Mediates the uptake of pyruvate into mitochondria. {ECO:0000269\|PubMed:22628558}.	FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MPC2

chr1:167904971

chr1:172356273

ENST00000271373

41_61

128.0

Transmembrane

Helical

Hgene

MPC2

chr1:167904971

chr1:172356273

ENST00000271373

73_90

128.0

Transmembrane

Helical

Hgene

MPC2

chr1:167904971

chr1:172356273

ENST00000271373

96_115

128.0

Transmembrane

Helical

Hgene

MPC2

chr1:167904971

chr1:172356273

ENST00000367846

41_61

128.0

Transmembrane

Helical

Hgene

MPC2

chr1:167904971

chr1:172356273

ENST00000367846

73_90

128.0

Transmembrane

Helical

Hgene

MPC2

chr1:167904971

chr1:172356273

ENST00000367846

96_115

128.0

Transmembrane

Helical

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000355305

28_294

692

870.0

Domain

Dynamin-type G

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000355305

515_621

692

870.0

Domain

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000355305

659_750

692

870.0

Domain

GED

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000358155

28_294

686

864.0

Domain

Dynamin-type G

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000358155

515_621

686

864.0

Domain

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000358155

659_750

686

864.0

Domain

GED

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000367731

28_294

682

860.0

Domain

Dynamin-type G

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000367731

515_621

682

860.0

Domain

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000367731

659_750

682

860.0

Domain

GED

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000355305

205_211

692

870.0

Nucleotide binding

GTP

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000355305

236_239

692

870.0

Nucleotide binding

GTP

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000355305

38_46

692

870.0

Nucleotide binding

GTP

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000358155

205_211

686

864.0

Nucleotide binding

GTP

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000358155

236_239

686

864.0

Nucleotide binding

GTP

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000358155

38_46

686

864.0

Nucleotide binding

GTP

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000367731

205_211

682

860.0

Nucleotide binding

GTP

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000367731

236_239

682

860.0

Nucleotide binding

GTP

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000367731

38_46

682

860.0

Nucleotide binding

GTP

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000355305

136_139

692

870.0

Region

G3 motif

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000355305

205_208

692

870.0

Region

G4 motif

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000355305

235_238

692

870.0

Region

G5 motif

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000355305

38_45

692

870.0

Region

G1 motif

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000355305

64_66

692

870.0

Region

G2 motif

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000358155

136_139

686

864.0

Region

G3 motif

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000358155

205_208

686

864.0

Region

G4 motif

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000358155

235_238

686

864.0

Region

G5 motif

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000358155

38_45

686

864.0

Region

G1 motif

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000358155

64_66

686

864.0

Region

G2 motif

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000367731

136_139

682

860.0

Region

G3 motif

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000367731

205_208

682

860.0

Region

G4 motif

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000367731

235_238

682

860.0

Region

G5 motif

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000367731

38_45

682

860.0

Region

G1 motif

Tgene

DNM3

chr1:167904971

chr1:172356273

ENST00000367731

64_66

682

860.0

Region

G2 motif

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Fusion Gene Sequence for MPC2-DNM3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>54656_54656_1_MPC2-DNM3_MPC2_chr1_167904971_ENST00000367846_DNM3_chr1_172356273_ENST00000358155_length(transcript)=5717nt_BP=308nt
CGCCCCCTCAACCTTCGCGGGGCGCGGGCCGCAGCTTTTCGGTTCACAGCGGGCAGGGAAAGCCGCGGGAAGGGTACTCCAGGCGAGAGG
CGGACGCGAGTCGTCGTGGCAGGAAAAGTGACTAGCTCCCCTTCGTTGTCAGCCAGGGACGAGAACACAGCCACGCTCCCACCCGGCTGC
CAACGATCCCTCGGCGGCGATGTCGGCCGCCGGTGCCCGAGGCCTGCGGGCCACCTACCACCGGCTCCTCGATAAAGTGGAGCTGATGCT
GCCCGAGAAATTGAGGCCGTTGTACAACCATCCAGCAGGTTAAAGATTTCATAAATTCCGAGCTCCTAGCACAGTTGTATTCTTCAGAGG
ACCAAAATACCCTGATGGAGGAATCTGCTGAGCAGGCTCAGCGCCGGGATGAGATGCTTCGAATGTATCAAGCACTGAAAGAAGCCCTTG
GGATAATTGGGGACATCAGCACAGCCACCGTGTCCACTCCGGCACCCCCTCCAGTGGATGACTCCTGGATACAGCACTCTCGCAGGTCAC
CTCCTCCAAGCCCCACAACCCAAAGGAGGCCAACACTAAGTGCTCCCCTCGCAAGGCCCACATCCGGCCGAGGACCAGCTCCTGCCATTC
CCTCTCCTGGCCCCCACTCTGGGGCTCCTCCAGTCCCATTCCGTCCAGGCCCATTACCTCCTTTCCCCAGCAGCAGTGACTCCTTCGGAG
CCCCTCCACAAGTTCCATCTAGGCCTACGAGGGCCCCGCCCAGTGTCCCAAGCCGGAGACCACCCCCATCACCAACTCGTCCCACTATAA
TCCGCCCACTAGAATCCTCCCTGTTAGACTAAACGAAGTGTCTGGCATGGCAATTAATCACTAATGAATTATGCGAAAGCAACATATTTG
ATAACCGTTGCAGTAAATCATGAGTAGTCGCATGTGTGGACATCAGTAGGCAAGTAACCAGTTTTACTAATGCATTCATCGCTCATCTTC
ATTGCTCATGGTATGTCAAACCTTTGGGGTTTGACTCAGAAACTGCTAACCTTTTAGAGGCTTTATATGTTGTACTGACCAAGGTAGGTT
TGTATAGCAGCCCTATACTTTGGGGATCATTTGCCTACCATGGCATATATTTGAAATTGCTTTGGACAAGTTTTCTAGGCTATCTACCAG
GTAGCTCATTAAACGTAATTCTTCAGATATGAGATAGTGGGCTTAGACCTAAGCCATACATATTTCTTTTCCCACATTCTGTTTAGGATG
ACAGTAATTCTGTTGTCTACCATTAATGCTACTACCTACTCCATAATTGCCTATTTAGCTCCTCTTTTCTTCCTTTTTATTTCATAAGAC
TGCTAGGAAGTGATTTTTTAAAATTAGGACTCCTTAAGAATAAACTTTTCCAGAAGCACGAGGTAGTTTGCAAAGGAAAAGTCTGCACTG
TTTGCTCTAAAGAGCTTCTCCTCATTCCAATGTGTTTTGCTTCATGCTAGAAGCATATGCAACAGTGAATAAAAGCTTCTTTTTTTGTTA
ATCAGTCAATAAATTTGGCTAATTAGTTTCAGAGTTCAAGGAAGAAGCAAAATATCACATCTCTAGAAGTGTTGGGAAAAATATAATTTC
TTTCTTTACTTATATTCACCTCATGGTAGGTTATATTGAAGGCTGACATGGAGAATGTTTACTTTTCTATTTGGCATAGCTAACTACACT
TTGATACTAACTCCAGTTTTACTATTATTATTTTGGTTGGAAAAAAAATTCACTCTTTACGTGCTAATTTGTAATCTTGTTTTGTAAGAA
TTTATCCTACCCTTGAAACAGGCTCAGTGTAACTGTATATCCATTCTAGGCTTTCTTAATAAATCTTGAGGCTATGGGATAATCACATTT
AAAGAATGGTTCCTGAAATGAAGTCAGTAGAAATGGCATGGGATAAGAGCAGAGCTCACACTTTTACAGTTGCAGTATTTCAAAGTCCCT
ATCCAGGTCACTCCAGAAAAGGGTATTGAAACGTTGAAATCTAAAGCAAATTTGCAATTTCTTAAGATTTCTAAAATTTACCAGAACAGT
TTAGCCTGGGGGTTAATAGTTAAGTCTTGAGGCTAAGTTTTGGACTACCAAGGACCAGATGATTCACATGTAGGAAACAGCCAGAAGCCA
ACTGGAATTTTGTGTGCTAACTGTTCCCAGACAGCAGAGCAAGTATTCACTGAGTAGGGGTGTCCCATGACACTATTTCATATTCTACAG
AAGTAAATCAGGTTTCACCAACTGAAATGTCTCCCTTTGAAAGTAGCAAACATGATTTGTATGTTAACTTAACTTTAATTTCCTGTGTAG
TTTACACCCAGAGCAGATACTCATAAAGTATAAAGTAAAAACTTTTAACCATTATTAAACAGAGAACTTGCCATGTTGAGTGCCATTGTA
TTGAACTTATTCTAAAGGCTTATGCTAACCCATTTATAATTGGTAAAAATCAGAAAATACAAGATTTACATAAAGGTCATTTCAACTTTT
AAGGTTACCAGTGATTGTATAAAAACATCACAATCCTAAATCCTCTCGTATCTCACCCCAAACCCCAAACTGGGGGAAAAAAAGTTAACT
CTTTGTGAATGGAACCAATGTGCAAGATACATACTGCATTTTTAAAATAGTGTCTCAGCTAAATGGAAAACTGTTAAGCAAACATCCATA
GTAAAACAAATAATCTTCAGTGAGATCTTTTTATAAAACTTCTTGTTTTTAGGATTCCCTTTGCTTCTTCCTTTGAATTCTCTAAAATAG
GCAGCTAACGGATTATATACTTCAGGGTTTGGCTTTGTGCTAAATGTGGTTTTGTGTTTTGCTGTATTTCAAAATTTTCCTTCTGTTAAA
GGAAAATATTGTGAATAACCACTGGTGTGTTCTTAGATCAGCACAAACCATGTCAAAAAAAATTGGAGATTTTTTTCCAATTTTCCTTCC
ACTGATCTTAGGCAGTAATAAACAATGGCATTTGTCATCTTTGGCACTTGCTTTTAGATTATAGTCCCACAGTTGCACTGCCCCAATTGT
CTACCTTTGTGGGTACATTTTTGTTCTTTACTCCTAAGTTATTTCTCATAGAACCCAGCCTACTCTAGAATTTCAGCAGTGACATTGGAG
AATATTTTTAATTTGCTGCAGTACTATGTCATATTATTAGTATGAATCTCATTTCCCAAAGGGTTTGTATTCTGCTAAAAGGAGATGCCA
ATGTTGAATGAAGTCTGAAACTCTAGTATGTGCATAGTTTGACGTGCAGCATGCACACCAGGCCTTAAGATGGGAATGTAGCTTAATGAT
TTTCTGTTTCCCATACCATTTCTAATCTTTTGTGTAATTTTCTCTTAACTGATTGCTCTGATATTGTAAACACAATAGATGTAGCTCTAT
CATGTCTAGCATAATTTAAAAAATCAGTGTTTTTAGGATTTGGGAAAATAAACTGTAAATGTTTATTTGATAGGTAAATATAGTTTTATT
GTCACATGCTAAATATTGCATGCATATTGACTAATTGGAATAACCATTTACTCAATTATGGACAGCTTATTGAAATAGTATTGATTTAGA
AAAAGTATATTGCATTTCTAAAAAACATCTACCAAGGTTACTCGTCTGAATATTGCTTTTAGCCGTGTTTTATAACATAGACGAGCAGTA
GGGTCTGTTTATTAGCAAATTTCCTATTTGTTCCAATACAAACTCACTTTATTCTAAAGTATATTAATGAAACCAGTTCCTGTGATGTAA
CTGTAAGCCTTCTCGACTTAGACTTAAAAAGTGGTCACATAGATTAATTTTGTGACTTTTTAGTATAGACTGTAGCCATAATTCTCAAAT
ATGAAATGGGACCTAATACCAGTATGTGATAAATGTTGATGTTTTCTGTGTACAAACACATTTTCTATGCATGTGTCTCTGTGTATATGG
CATATACCTAGTAAGTATGTTTCTGTAAGTATGTGTATTTTATGTCCATTTGAGTAGGTAGGTAGGTTTTAAAAATACTAGTTAAAATGC
CACAAGCATGAGTGTGATTGTATGTGCACTGTGTGTATATATATAAATATATGTATATGTATGGTTGTAAATATCTATGTATACATGTAC
TTAGTATGTGTGGTATCAGGATATTTTTTAAACTGTGATAATACAACAGATAGCTTTGAATGATCTGCCATAACATGTGGTAACAATAGT
TCATTTCTCATAACATATATGAGGTATACAAAATTTTCTAACTCCAGATTGTAGTCATTTTGAGAGGTACAAAGCTCATAATTACCATGA
CAACATGGTAATGTCCATAGACATTTGTATCTGAATCCACAAGAAGATCTGAATCTAAGAAGGAATTACCTTTGACAATATTTTTCGGTA
AGAAGTAAAACCTCTGGAGACCTATCTTTAAGATCTCTAATTGGAATTATAAATTATTTTTGGATTGCTGAGCTGAATCTTAAAAAGCCA
AGTTGATATACATAGTCATTTTTCCTCTATGGTAGAAGTAAAAAAAAAAAAAAAGGACATAGCAACATTAAAGTAGTGGATTTTTCTGAG
TAAATTTGCTGAAAATATAAGAGAGAAGCTATCTAATACCTTGGAGGTAGGTCATCCACTTTTTCAGGTAAACATTTTTCATTTGGCAAA
TGGCATAATTATTTGAAAGTGACAGGAATCTCCTCAGAATGAAGAATAAAGCCTACTAGGTCTCTAACTGTTGAACTCATGAAAGAAGAT
AGTGTATGAGACTTAAGCCATGAGTTTTGTATCATTTCAATTAGAAGACTACTAGCTGTGAGCTCAGAGTTTAATGTAAATGAATCTAGA
TGATTTTGAAGAAATGATTATTCGTTCACCAGATCACTCATTGTACATTCTAAAAAGCTCAAATGAGTCTTCTAGATACTCTTACTCATC
CTGTCTGGTTGCTATGTTTAAAATTATGTGGTGCTGTGTAGGTGAAACTTTAAGAATATTTTTGAAGCATATGTAATATATGCACTGCTA
TTTGTGTGTGTGTGTGTGTCTTTGTATATATGTAAGAATGTGTGTATGTGTGAGAGCAAGAGAGAGGAAACTCAAAGAGGAGTGTTTGTC
TTAAGACCTGTTCATACTGGTATATTGGTGAGACTTCTCACTTCTGGTTGGAGGTTTCACATATGGCTCAACTCAAGTCATTAATCTCTT
TTTAATTTTTACTCTTGAATTCCTTAAACTTCGCTCATTATGAAATGTTTTAAAATTATGACAAAAATTACTCTGTCTAACCACTTGCCT
TGTCTGCTACCAGTTTGTTAAAAATTATTCCCCCCAACCAGTAATTCCACCAGTACTACTTGATTTGTGTTATATTTCCTATGTACATGT
ACAGCCTTTGTTTTGCTTGCTTGTCTATTTTTACTTTCCCTTTTTTGGGTCAAATTTTTCTTTTGCTTTGTTTGAAGAAGGAATATACAG
AAGTAAAATCTTGTCTTCTCTGCTGATTCTTTAATTAATATGAGCCGGATACTTTCCACTGTCTTCTTGGCACTTTCAGGATTTCTTAAT
GCTGATATATGGACTCTTAGAATGGAATTTTTGAAGAAAAATCTCAAAGCCTGTATCGTTCTTGAAGGTCACATGTACCTATTGTGAAAA

>54656_54656_1_MPC2-DNM3_MPC2_chr1_167904971_ENST00000367846_DNM3_chr1_172356273_ENST00000358155_length(amino acids)=165AA_BP=
MYSSEDQNTLMEESAEQAQRRDEMLRMYQALKEALGIIGDISTATVSTPAPPPVDDSWIQHSRRSPPPSPTTQRRPTLSAPLARPTSGRG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MPC2-DNM3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MPC2-DNM3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MPC2-DNM3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source