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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:MPDZ-ITPK1 (FusionGDB2 ID:54671)

Fusion Gene Summary for MPDZ-ITPK1

Fusion gene summary

Fusion gene information	Fusion gene name: MPDZ-ITPK1
	Fusion gene ID: 54671
		Hgene	Tgene
	Gene symbol	MPDZ	ITPK1
	Gene ID	84708	3705
	Gene name	ligand of numb-protein X 1	inositol-tetrakisphosphate 1-kinase
	Synonyms	LNX\|MPDZ\|PDZRN2	ITRPK1
	Cytomap	4q12	14q32.12
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase LNXPDZ domain-containing ring finger protein 2RING-type E3 ubiquitin transferase LNXligand of numb-protein X 1, E3 ubiquitin protein ligasemulti-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNXnumb-binding pr	inositol-tetrakisphosphate 1-kinaseinositol 1,3,4-trisphosphate 5/6-kinaseins(1,3,4)P(3) 5/6-kinase
	Modification date	20200327	20200313
	UniProtAcc	O75970	Q13572
	Ensembl transtripts involved in fusion gene	ENST00000319217, ENST00000381015, ENST00000381022, ENST00000447879, ENST00000536827, ENST00000541718, ENST00000546205, ENST00000538841, ENST00000540202, ENST00000541093,	ENST00000354313, ENST00000555495, ENST00000556603, ENST00000556954, ENST00000267615,
Fusion gene scores	* DoF score	7 X 9 X 5=315	9 X 8 X 7=504
	# samples	9	8
	** MAII score	log2(9/315*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/504*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MPDZ [Title/Abstract] AND ITPK1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MPDZ(13247634)-ITPK1(93408249), # samples:3
Anticipated loss of major functional domain due to fusion event.	MPDZ-ITPK1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. MPDZ-ITPK1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MPDZ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ITPK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-PG-A7D5-01A	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-

Top

Fusion Gene ORF analysis for MPDZ-ITPK1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000319217	ENST00000354313	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000319217	ENST00000555495	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000319217	ENST00000556603	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000319217	ENST00000556954	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000381015	ENST00000354313	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000381015	ENST00000555495	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000381015	ENST00000556603	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000381015	ENST00000556954	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000381022	ENST00000354313	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000381022	ENST00000555495	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000381022	ENST00000556603	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000381022	ENST00000556954	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000447879	ENST00000354313	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000447879	ENST00000555495	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000447879	ENST00000556603	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000447879	ENST00000556954	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000536827	ENST00000354313	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000536827	ENST00000555495	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000536827	ENST00000556603	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000536827	ENST00000556954	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000541718	ENST00000354313	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000541718	ENST00000555495	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000541718	ENST00000556603	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000541718	ENST00000556954	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000546205	ENST00000354313	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000546205	ENST00000555495	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000546205	ENST00000556603	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
5CDS-intron	ENST00000546205	ENST00000556954	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
Frame-shift	ENST00000319217	ENST00000267615	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
Frame-shift	ENST00000541718	ENST00000267615	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
Frame-shift	ENST00000546205	ENST00000267615	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
In-frame	ENST00000381015	ENST00000267615	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
In-frame	ENST00000381022	ENST00000267615	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
In-frame	ENST00000447879	ENST00000267615	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
In-frame	ENST00000536827	ENST00000267615	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
intron-3CDS	ENST00000538841	ENST00000267615	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
intron-3CDS	ENST00000540202	ENST00000267615	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
intron-3CDS	ENST00000541093	ENST00000267615	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
intron-intron	ENST00000538841	ENST00000354313	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
intron-intron	ENST00000538841	ENST00000555495	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
intron-intron	ENST00000538841	ENST00000556603	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
intron-intron	ENST00000538841	ENST00000556954	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
intron-intron	ENST00000540202	ENST00000354313	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
intron-intron	ENST00000540202	ENST00000555495	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
intron-intron	ENST00000540202	ENST00000556603	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
intron-intron	ENST00000540202	ENST00000556954	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
intron-intron	ENST00000541093	ENST00000354313	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
intron-intron	ENST00000541093	ENST00000555495	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
intron-intron	ENST00000541093	ENST00000556603	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-
intron-intron	ENST00000541093	ENST00000556954	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000381022	MPDZ	chr9	13247634	-	ENST00000267615	ITPK1	chr14	93408249	-	5225	234	2825	2331	164
ENST00000536827	MPDZ	chr9	13247634	-	ENST00000267615	ITPK1	chr14	93408249	-	5217	226	2817	2323	164
ENST00000447879	MPDZ	chr9	13247634	-	ENST00000267615	ITPK1	chr14	93408249	-	5217	226	2817	2323	164
ENST00000381015	MPDZ	chr9	13247634	-	ENST00000267615	ITPK1	chr14	93408249	-	5217	226	2817	2323	164

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000381022	ENST00000267615	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-	0.6474548	0.35254526
ENST00000536827	ENST00000267615	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-	0.6458521	0.3541479
ENST00000447879	ENST00000267615	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-	0.6458521	0.3541479
ENST00000381015	ENST00000267615	MPDZ	chr9	13247634	-	ITPK1	chr14	93408249	-	0.6458521	0.3541479

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Fusion Genomic Features for MPDZ-ITPK1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MPDZ-ITPK1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:13247634/chr14:93408249)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MPDZ O75970	ITPK1 Q13572
FUNCTION: Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250\|UniProtKB:O55164, ECO:0000269\|PubMed:11150294, ECO:0000269\|PubMed:15312654}.	FUNCTION: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (PubMed:11909533, PubMed:12925536, PubMed:17616525). Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:17616525). {ECO:0000269\|PubMed:11909533, ECO:0000269\|PubMed:12925536, ECO:0000269\|PubMed:17616525}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000319217

1_63

2071.0

Domain

L27

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381015

1_63

2071.0

Domain

L27

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381022

1_63

2042.0

Domain

L27

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000447879

1_63

2038.0

Domain

L27

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000536827

1_63

2009.0

Domain

L27

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000541718

1_63

2042.0

Domain

L27

Tgene

ITPK1

chr9:13247634

chr14:93408249

ENST00000354313

117_325

315.0

Domain

ATP-grasp

Tgene

ITPK1

chr9:13247634

chr14:93408249

ENST00000354313

188_199

315.0

Nucleotide binding

Note=ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000319217

1818_1848

2071.0

Compositional bias

Note=Ser-rich

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381015

1818_1848

2071.0

Compositional bias

Note=Ser-rich

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381022

1818_1848

2042.0

Compositional bias

Note=Ser-rich

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000447879

1818_1848

2038.0

Compositional bias

Note=Ser-rich

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000536827

1818_1848

2009.0

Compositional bias

Note=Ser-rich

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000541718

1818_1848

2042.0

Compositional bias

Note=Ser-rich

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000319217

1008_1089

2071.0

Domain

PDZ 6

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000319217

1151_1243

2071.0

Domain

PDZ 7

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000319217

1350_1433

2071.0

Domain

PDZ 8

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000319217

137_224

2071.0

Domain

PDZ 1

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000319217

1483_1564

2071.0

Domain

PDZ 9

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000319217

1629_1712

2071.0

Domain

PDZ 10

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000319217

1725_1807

2071.0

Domain

PDZ 11

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000319217

1862_1948

2071.0

Domain

PDZ 12

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000319217

1987_2070

2071.0

Domain

PDZ 13

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000319217

257_337

2071.0

Domain

PDZ 2

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000319217

377_463

2071.0

Domain

PDZ 3

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000319217

553_634

2071.0

Domain

PDZ 4

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000319217

700_786

2071.0

Domain

PDZ 5

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381015

1008_1089

2071.0

Domain

PDZ 6

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381015

1151_1243

2071.0

Domain

PDZ 7

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381015

1350_1433

2071.0

Domain

PDZ 8

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381015

137_224

2071.0

Domain

PDZ 1

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381015

1483_1564

2071.0

Domain

PDZ 9

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381015

1629_1712

2071.0

Domain

PDZ 10

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381015

1725_1807

2071.0

Domain

PDZ 11

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381015

1862_1948

2071.0

Domain

PDZ 12

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381015

1987_2070

2071.0

Domain

PDZ 13

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381015

257_337

2071.0

Domain

PDZ 2

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381015

377_463

2071.0

Domain

PDZ 3

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381015

553_634

2071.0

Domain

PDZ 4

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381015

700_786

2071.0

Domain

PDZ 5

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381022

1008_1089

2042.0

Domain

PDZ 6

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381022

1151_1243

2042.0

Domain

PDZ 7

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381022

1350_1433

2042.0

Domain

PDZ 8

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381022

137_224

2042.0

Domain

PDZ 1

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381022

1483_1564

2042.0

Domain

PDZ 9

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381022

1629_1712

2042.0

Domain

PDZ 10

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381022

1725_1807

2042.0

Domain

PDZ 11

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381022

1862_1948

2042.0

Domain

PDZ 12

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381022

1987_2070

2042.0

Domain

PDZ 13

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381022

257_337

2042.0

Domain

PDZ 2

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381022

377_463

2042.0

Domain

PDZ 3

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381022

553_634

2042.0

Domain

PDZ 4

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000381022

700_786

2042.0

Domain

PDZ 5

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000447879

1008_1089

2038.0

Domain

PDZ 6

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000447879

1151_1243

2038.0

Domain

PDZ 7

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000447879

1350_1433

2038.0

Domain

PDZ 8

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000447879

137_224

2038.0

Domain

PDZ 1

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000447879

1483_1564

2038.0

Domain

PDZ 9

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000447879

1629_1712

2038.0

Domain

PDZ 10

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000447879

1725_1807

2038.0

Domain

PDZ 11

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000447879

1862_1948

2038.0

Domain

PDZ 12

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000447879

1987_2070

2038.0

Domain

PDZ 13

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000447879

257_337

2038.0

Domain

PDZ 2

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000447879

377_463

2038.0

Domain

PDZ 3

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000447879

553_634

2038.0

Domain

PDZ 4

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000447879

700_786

2038.0

Domain

PDZ 5

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000536827

1008_1089

2009.0

Domain

PDZ 6

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000536827

1151_1243

2009.0

Domain

PDZ 7

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000536827

1350_1433

2009.0

Domain

PDZ 8

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000536827

137_224

2009.0

Domain

PDZ 1

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000536827

1483_1564

2009.0

Domain

PDZ 9

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000536827

1629_1712

2009.0

Domain

PDZ 10

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000536827

1725_1807

2009.0

Domain

PDZ 11

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000536827

1862_1948

2009.0

Domain

PDZ 12

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000536827

1987_2070

2009.0

Domain

PDZ 13

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000536827

257_337

2009.0

Domain

PDZ 2

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000536827

377_463

2009.0

Domain

PDZ 3

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000536827

553_634

2009.0

Domain

PDZ 4

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000536827

700_786

2009.0

Domain

PDZ 5

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000541718

1008_1089

2042.0

Domain

PDZ 6

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000541718

1151_1243

2042.0

Domain

PDZ 7

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000541718

1350_1433

2042.0

Domain

PDZ 8

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000541718

137_224

2042.0

Domain

PDZ 1

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000541718

1483_1564

2042.0

Domain

PDZ 9

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000541718

1629_1712

2042.0

Domain

PDZ 10

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000541718

1725_1807

2042.0

Domain

PDZ 11

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000541718

1862_1948

2042.0

Domain

PDZ 12

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000541718

1987_2070

2042.0

Domain

PDZ 13

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000541718

257_337

2042.0

Domain

PDZ 2

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000541718

377_463

2042.0

Domain

PDZ 3

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000541718

553_634

2042.0

Domain

PDZ 4

Hgene

MPDZ

chr9:13247634

chr14:93408249

ENST00000541718

700_786

2042.0

Domain

PDZ 5

Tgene

ITPK1

chr9:13247634

chr14:93408249

ENST00000267615

117_325

300

415.0

Domain

ATP-grasp

Tgene

ITPK1

chr9:13247634

chr14:93408249

ENST00000556603

117_325

300

415.0

Domain

ATP-grasp

Tgene

ITPK1

chr9:13247634

chr14:93408249

ENST00000267615

188_199

300

415.0

Nucleotide binding

Note=ATP

Tgene

ITPK1

chr9:13247634

chr14:93408249

ENST00000556603

188_199

300

415.0

Nucleotide binding

Note=ATP

Top

Fusion Gene Sequence for MPDZ-ITPK1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>54671_54671_1_MPDZ-ITPK1_MPDZ_chr9_13247634_ENST00000381015_ITPK1_chr14_93408249_ENST00000267615_length(transcript)=5217nt_BP=226nt
TGCTGTTAATCATTTCAGAGAAGAACACTGAACTTTGAAAAAAATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCG
CTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAAGACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAG
TCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGACCAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCAC
ATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCACAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCG
GCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCGGCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAG
GCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCGGCTGCAACGCCGGCGTGTCGCCCAGCTTCCAGCAGCATTGTGTGGCC
TCCCTGGCCACCAAGGCCTCCTCCCAGTAGCCACGGAGCCGGGACCCAGAGGGGCAGCGCAGGGCGCAGAGCACACCCGCTGGGCCAGCA
GCTCCCAACGGCGATGCTACTACTAAGAATCCCCAGTGATCTGATTCTTCTGTTTTTTAATTTTTAACCTGATTCTCTGATGTCATGATC
TAAATGAGGGGTAGTGGGGGATGGAAGAGAGTACCAGGTGGTCCACCGTTGGGGAGTGGGGCCGTCCGCCTGCTCTCTACTGTGCAGACC
TCCTAACTGAGTTTACACACGCTTGTGTTTGCAACACTAGGTCTGGATGGGAGGTGAGGGGTGTGCGTATGGCTGCCATGCCAGTGTCTG
TGCACATCCCTGTCTGTTGGTCTCCATGGCCACTGTGGACCGGGACCCTTGGGGGAAGCCTGCCCATGTCGGGCTGTGGGAGGCTGATCG
GTGCATGTGAGAGTGGCTTCCCTTCTGCCTGACTCCCCACTCCCTGACCTGCCCCTTCCTTGTTTTTCCTCCTACTGGTCTCCACCAAGG
CTTTGTTAGCCCCCACCCTGCCTGGTGTGCAGCTAACCCCTCCCTCCCCACAGCCAGAGGAGGCCACAGACCCCTCAGGGGAGTTCCGCG
CTGGGGTCTGGGCTGTGCTCCCTCACTAAAGGGAAGGAAAGGAAGCTGGGCGTCCTCTGGGCCCCCCAACACACGTCCCATTTAGCCCTG
CACAGCGGTCTCCTTCCCCTAAGCCAGCACTGCTGCTCCCTGGAGCCCGGGAAGGAGGCTGCCTGGCTGGAGGCCCGAGCCGATGGCGCC
TGTGCTGAGGATTTGTGCTGTGATTTGGGCAAATCATTCCAGGTCTTTGGGCCTCCACCCCCTTGTCTCTAGTGGACATTTGAGATCAGA
GAGCACCACAGGGCTGGCTTTGTGCCCTAACCCCTGGGATGCAGCCTGCCTTTCCATAAAGTCACCTAGGTGAGGATAGGCGCGGGAGCC
TCGGCATGACACCATGGAGATCGGGGCCCTCTTCCCAGTGGGTTCACTCCTTTTCACACCTGCTGGGTCCCTCCTCACCCAGCAGGCCTG
GTCCACCTCTCATTGCAAGCCCCAAGCACTGAGCCAGCAGGTGCCAGGGAGCCACCCGCCCCCCATCGCTTCTGCACACCTCAGACTCAC
CCCATCACCTTGGCAGCAAAGCACTGGCTCTGCCGTCTGACCCCTGATCCAGGCAGCCCCCTCTGCAGAGAAAAGGGTTGGGGAGAAGCC
TCTGCAGTCCTGGAAGATGTGGGGTGCTGGGTGAGAGGCATCAGCCCCCACAAGTATGTTTTTGTGTCTTAAGATAGCAGTTTACTTTGA
AAAAGTGAAAAAGGCTTCCGGGCTGTCCTCTGCCCAGTGAGATGGAGGACGCTAGAGAAAGTGCTGAGTGTCCCGAGAGAGGCCCCCGAG
CCAGTGCATGGAGGTCCTTCGGCCTGGCTCAGCTGGGCTGCAGGATGCCCACTTTGAGGAGGGAGGCACAGGGCTTGGGCGAGGGGCAGA
GGCCATCAGAACTGCCCGGCTTTTTTGGAAACTGAGGACCCAACAACTAACCACGTTTACACGACTTGAGTTTTGAACCCCGATTAATGT
CTGTACGTCACCTTTCCTAGTTCTGACCCTGAGCCCTGGGGAACAGGAAAGCGTGGCTGGCCTCTTGCACTGCTTTGTCTCCAAAATAAA
CTACTGAAATCAAACCGCATTTCACACGTGTTTACACATGTTGCTCAAGTTTGTTATGTCATACTCCCAGTCCTTAAAAGACGTTTAATA
AAACAGCTTTACCTTTTAAAAATAAAATTTCAATCCCAGTCTGCCTCAGGTACGGGTGGGGGTGTGCAGCGTGACTCCTGGCTGTGTTCC
TGTACCGTTTGTGGCCTCCGGGGTCTTGCGCGTCCAGGGCCCAGATACCGAGTAACTGCCATGTGGTGTCGTGGTGGCGTCCATAGGCCT
CCGTGGTGGGGCGGGGGCGGGGCTGTGGGTGTGCAGGGCAGCTGCATTTTCCAAGAGTGGAGATGGAGGATGGAGATTTGCTTCGTAAAG
GCCTGGGAGCTACATGGGAGGTAGGGAGGGGCCAGCCACACCCAGGGCTGGGGGGCCGGTGGACTCTGCCCAGTGAAGCCAGGGGAGTGT
CAGCAATGAGGGGCCTGGACAGCGACGCGGGACCCGCACCTGGGAGCGGCAGAGATGGAGCCCAGCTCGCTAAACGTACCCTAAGGGTGC
ACGCTGACCATCTTTGATCCCTGGACAGTGTCCATAGAGTTGTCTCCCCTTCGGTCACATTGTCCCTGGCCTTGGAGTTTCTGCCTCAGG
GAAAGACCCACTAAAACCACCCGGGCTCTGGCGGCCTCCTCTTCTCCAGAGCATGGTGGCGCTGCCTCCTGAGCAGAGTCACTGAGAGTG
TCTGGGTCCAAGGAAGGGACCCACTTAGCAAAGGTTGTTGTGTGGTGCTGTGCAGGCACGGCGCCTGGAGTTGGCCCCGCCAGCATCGGG
GTGGCTTGGGGCTCTGGTTCCTAAGCTTCTGCTTCTGAGTTGGTCAGCACGTTGGCTCTGCGCCCTGCAGTGCCTGTCTTGATGGTGGTC
CCTGGATGTGCTGAAGGGCTCCAGGAGCAAGGGGCCAGACCACACTTTGGCTGAGTCCTTGGGTAGTTTCAGAGGGTCACCTGCACAGTC
TGCATTGAGCACCCTGGGGCTGAGGCCGTGGGTCAAGTTCTGCCTGACAGTGCTTTGATTATATGGTGATGTGATTCTGCAAACATAACC
CCCCAACTGAGTGCCAGCTGCTGGGTGTCCCCACCCCAAGAGCCAAGGGGAGGCCACCCTGGAACTGGTGCTTTGCCCTTGGTGTCATGG
AGGTGTCTGGGTCCACACGTGGTGGGTGGGCTGGGCCTGCAGTCACCCAGCATGGCCGGCGGGATTGGACCCAGCTGCAACCTGGCAGGT
TCCATGGGGCTTCCTGTGCCTGGGCCTGCCTGTGTCTCATGCCTGTCAATAAAGGAGAAAGCAACCTGGGAAAAACATTCCTCTCTGTAC
CCAGGGGACTGCCAAGTGTGCTTTATAGAAGGCTGGAAGACCGACTGAAGTAGGAAGCTGTCACATGTTTGAGCCAACTGAGCAAAGCAG
CTGTTGCCTGCCAGACAGCCACCCCAAGACCAAGGGAGCCAGCCTGTCGTTTGTCCTTCTAGCCTGGAAGACCAGTTCTTGGCTCTTGGG
CACTCACATTGGCCACTGGCCACAACTGCTGAATGGCTTCACTAATGTCCCTGGGGTCTGTATCTGCCCTCTCTTCTATTCCCTAGAAAC
TCTGGCCGGGCATGGCGGCTCACGCCTGTCATCCCAGCACTTAGGGAGGCTGAGGCAGGTGGATCACAAGGTCAAGAGATCGACACCATC
CTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGACATGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGA
GGCTGAGGCAGGAGAATTGCTTGAACTCGGGAGGCGTAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGCAACAGAGCA
AGACTCCTCAAAAAACAAACAAACAAACAAACAAACTCTGATCATTCACCCGGTGGGATCCCCGGCAGCTCCTTCTCCTTCCCGAGCTGT
GGCTCATGGGCCATTGGATTCAGAGACCTTGAGCTGGGTGCTGGCTGCCCTAAAGGAGCACGACCCCTCCAGCCTGGTGACCGGGAGGCA
GAGAAGTGCAGCTGTCCTTGACAAAGGCCCAGCCTCTGCTGCCTCAGGCCAGCCTGGCCACACCCCGATGCCACAGTCATCTGCCCCGCC
CAGGCATAAGCCTGACTCAGGTGATACAGGCGAGGCTTCTCCCATGGGTCCTCCCCTTGTGAGAAAGGGTCTGTGCTGTGTACCTTCTCT
CTGCACAGCCATTGTCAGTGTGGTTTGGAGTGAGTGAGCCTCCCGCACTGCTCAGGGGAGAGCTGGTGAGCATGACTCCATGGCCTCCTG
CTGGTTGGGGTCTTCTTCTGATTCTCACCCGCAGGAGCACCCAGACCCCCCCTTTTCAGAAATGATTACATTTTCCCTTCAAGAGTCATC
TGTGACCTGGTGGTGTGGAGGGACTGTCCCCTCCTGCAGCCTGGCCGACCCCCTTCCTCCAGGGCTGTGTGGAATCACCTCTCAGAAGCT
CACTCTGAAAAGCCACTCACAGGGATTTCACCAGGATGTTGCTGTTCCTGCCGACACCTGGGCTTTGTGACAAATGCTGTTTGCTTCAAG
CTGTTCACAAGCAACTTCACCAGAATCCCAAGCTGGTTCGTACTTAATTTGTGTACATACATATGCATAATATACATGACCATGTATGAG
ATACAGACACCATGGCTTCTGTCCATTGGCTCATTCGCCTGGTCGCATGTTCACTCCATGAGGTTAGGACACTGCGGGTGGCTTTGGGAT
GGGTGGTTTCAGGGACAAGGTGTCGCTATGATCTCTGTATTTGCTAACTAGTCTTGTTTTGATTTCTAACGGTCTAGTGGAGTACAGTTA

>54671_54671_1_MPDZ-ITPK1_MPDZ_chr9_13247634_ENST00000381015_ITPK1_chr14_93408249_ENST00000267615_length(amino acids)=164AA_BP=
MSRDQRWSACTLRVRLASWAPSLPLPGAGPASLSRPLIADTPLASLGRVHRPPSPGCGWPLPTSHVAPRPLRSKSPSSISTLGKCSCPAH

--------------------------------------------------------------
>54671_54671_2_MPDZ-ITPK1_MPDZ_chr9_13247634_ENST00000381022_ITPK1_chr14_93408249_ENST00000267615_length(transcript)=5225nt_BP=234nt
ATTTTAATTGCTGTTAATCATTTCAGAGAAGAACACTGAACTTTGAAAAAAATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCA
GCAGAGCGCTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAAGACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCT
CTCTTCAGTCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGACCAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCC
TGAACCACATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCACAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGG
CCGAGCCGGCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCGGCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGA
AGGCTGAGGCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCGGCTGCAACGCCGGCGTGTCGCCCAGCTTCCAGCAGCATT
GTGTGGCCTCCCTGGCCACCAAGGCCTCCTCCCAGTAGCCACGGAGCCGGGACCCAGAGGGGCAGCGCAGGGCGCAGAGCACACCCGCTG
GGCCAGCAGCTCCCAACGGCGATGCTACTACTAAGAATCCCCAGTGATCTGATTCTTCTGTTTTTTAATTTTTAACCTGATTCTCTGATG
TCATGATCTAAATGAGGGGTAGTGGGGGATGGAAGAGAGTACCAGGTGGTCCACCGTTGGGGAGTGGGGCCGTCCGCCTGCTCTCTACTG
TGCAGACCTCCTAACTGAGTTTACACACGCTTGTGTTTGCAACACTAGGTCTGGATGGGAGGTGAGGGGTGTGCGTATGGCTGCCATGCC
AGTGTCTGTGCACATCCCTGTCTGTTGGTCTCCATGGCCACTGTGGACCGGGACCCTTGGGGGAAGCCTGCCCATGTCGGGCTGTGGGAG
GCTGATCGGTGCATGTGAGAGTGGCTTCCCTTCTGCCTGACTCCCCACTCCCTGACCTGCCCCTTCCTTGTTTTTCCTCCTACTGGTCTC
CACCAAGGCTTTGTTAGCCCCCACCCTGCCTGGTGTGCAGCTAACCCCTCCCTCCCCACAGCCAGAGGAGGCCACAGACCCCTCAGGGGA
GTTCCGCGCTGGGGTCTGGGCTGTGCTCCCTCACTAAAGGGAAGGAAAGGAAGCTGGGCGTCCTCTGGGCCCCCCAACACACGTCCCATT
TAGCCCTGCACAGCGGTCTCCTTCCCCTAAGCCAGCACTGCTGCTCCCTGGAGCCCGGGAAGGAGGCTGCCTGGCTGGAGGCCCGAGCCG
ATGGCGCCTGTGCTGAGGATTTGTGCTGTGATTTGGGCAAATCATTCCAGGTCTTTGGGCCTCCACCCCCTTGTCTCTAGTGGACATTTG
AGATCAGAGAGCACCACAGGGCTGGCTTTGTGCCCTAACCCCTGGGATGCAGCCTGCCTTTCCATAAAGTCACCTAGGTGAGGATAGGCG
CGGGAGCCTCGGCATGACACCATGGAGATCGGGGCCCTCTTCCCAGTGGGTTCACTCCTTTTCACACCTGCTGGGTCCCTCCTCACCCAG
CAGGCCTGGTCCACCTCTCATTGCAAGCCCCAAGCACTGAGCCAGCAGGTGCCAGGGAGCCACCCGCCCCCCATCGCTTCTGCACACCTC
AGACTCACCCCATCACCTTGGCAGCAAAGCACTGGCTCTGCCGTCTGACCCCTGATCCAGGCAGCCCCCTCTGCAGAGAAAAGGGTTGGG
GAGAAGCCTCTGCAGTCCTGGAAGATGTGGGGTGCTGGGTGAGAGGCATCAGCCCCCACAAGTATGTTTTTGTGTCTTAAGATAGCAGTT
TACTTTGAAAAAGTGAAAAAGGCTTCCGGGCTGTCCTCTGCCCAGTGAGATGGAGGACGCTAGAGAAAGTGCTGAGTGTCCCGAGAGAGG
CCCCCGAGCCAGTGCATGGAGGTCCTTCGGCCTGGCTCAGCTGGGCTGCAGGATGCCCACTTTGAGGAGGGAGGCACAGGGCTTGGGCGA
GGGGCAGAGGCCATCAGAACTGCCCGGCTTTTTTGGAAACTGAGGACCCAACAACTAACCACGTTTACACGACTTGAGTTTTGAACCCCG
ATTAATGTCTGTACGTCACCTTTCCTAGTTCTGACCCTGAGCCCTGGGGAACAGGAAAGCGTGGCTGGCCTCTTGCACTGCTTTGTCTCC
AAAATAAACTACTGAAATCAAACCGCATTTCACACGTGTTTACACATGTTGCTCAAGTTTGTTATGTCATACTCCCAGTCCTTAAAAGAC
GTTTAATAAAACAGCTTTACCTTTTAAAAATAAAATTTCAATCCCAGTCTGCCTCAGGTACGGGTGGGGGTGTGCAGCGTGACTCCTGGC
TGTGTTCCTGTACCGTTTGTGGCCTCCGGGGTCTTGCGCGTCCAGGGCCCAGATACCGAGTAACTGCCATGTGGTGTCGTGGTGGCGTCC
ATAGGCCTCCGTGGTGGGGCGGGGGCGGGGCTGTGGGTGTGCAGGGCAGCTGCATTTTCCAAGAGTGGAGATGGAGGATGGAGATTTGCT
TCGTAAAGGCCTGGGAGCTACATGGGAGGTAGGGAGGGGCCAGCCACACCCAGGGCTGGGGGGCCGGTGGACTCTGCCCAGTGAAGCCAG
GGGAGTGTCAGCAATGAGGGGCCTGGACAGCGACGCGGGACCCGCACCTGGGAGCGGCAGAGATGGAGCCCAGCTCGCTAAACGTACCCT
AAGGGTGCACGCTGACCATCTTTGATCCCTGGACAGTGTCCATAGAGTTGTCTCCCCTTCGGTCACATTGTCCCTGGCCTTGGAGTTTCT
GCCTCAGGGAAAGACCCACTAAAACCACCCGGGCTCTGGCGGCCTCCTCTTCTCCAGAGCATGGTGGCGCTGCCTCCTGAGCAGAGTCAC
TGAGAGTGTCTGGGTCCAAGGAAGGGACCCACTTAGCAAAGGTTGTTGTGTGGTGCTGTGCAGGCACGGCGCCTGGAGTTGGCCCCGCCA
GCATCGGGGTGGCTTGGGGCTCTGGTTCCTAAGCTTCTGCTTCTGAGTTGGTCAGCACGTTGGCTCTGCGCCCTGCAGTGCCTGTCTTGA
TGGTGGTCCCTGGATGTGCTGAAGGGCTCCAGGAGCAAGGGGCCAGACCACACTTTGGCTGAGTCCTTGGGTAGTTTCAGAGGGTCACCT
GCACAGTCTGCATTGAGCACCCTGGGGCTGAGGCCGTGGGTCAAGTTCTGCCTGACAGTGCTTTGATTATATGGTGATGTGATTCTGCAA
ACATAACCCCCCAACTGAGTGCCAGCTGCTGGGTGTCCCCACCCCAAGAGCCAAGGGGAGGCCACCCTGGAACTGGTGCTTTGCCCTTGG
TGTCATGGAGGTGTCTGGGTCCACACGTGGTGGGTGGGCTGGGCCTGCAGTCACCCAGCATGGCCGGCGGGATTGGACCCAGCTGCAACC
TGGCAGGTTCCATGGGGCTTCCTGTGCCTGGGCCTGCCTGTGTCTCATGCCTGTCAATAAAGGAGAAAGCAACCTGGGAAAAACATTCCT
CTCTGTACCCAGGGGACTGCCAAGTGTGCTTTATAGAAGGCTGGAAGACCGACTGAAGTAGGAAGCTGTCACATGTTTGAGCCAACTGAG
CAAAGCAGCTGTTGCCTGCCAGACAGCCACCCCAAGACCAAGGGAGCCAGCCTGTCGTTTGTCCTTCTAGCCTGGAAGACCAGTTCTTGG
CTCTTGGGCACTCACATTGGCCACTGGCCACAACTGCTGAATGGCTTCACTAATGTCCCTGGGGTCTGTATCTGCCCTCTCTTCTATTCC
CTAGAAACTCTGGCCGGGCATGGCGGCTCACGCCTGTCATCCCAGCACTTAGGGAGGCTGAGGCAGGTGGATCACAAGGTCAAGAGATCG
ACACCATCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGACATGGTGGTGGGCGCCTGTAGTCCCAGCT
ACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACTCGGGAGGCGTAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGCA
ACAGAGCAAGACTCCTCAAAAAACAAACAAACAAACAAACAAACTCTGATCATTCACCCGGTGGGATCCCCGGCAGCTCCTTCTCCTTCC
CGAGCTGTGGCTCATGGGCCATTGGATTCAGAGACCTTGAGCTGGGTGCTGGCTGCCCTAAAGGAGCACGACCCCTCCAGCCTGGTGACC
GGGAGGCAGAGAAGTGCAGCTGTCCTTGACAAAGGCCCAGCCTCTGCTGCCTCAGGCCAGCCTGGCCACACCCCGATGCCACAGTCATCT
GCCCCGCCCAGGCATAAGCCTGACTCAGGTGATACAGGCGAGGCTTCTCCCATGGGTCCTCCCCTTGTGAGAAAGGGTCTGTGCTGTGTA
CCTTCTCTCTGCACAGCCATTGTCAGTGTGGTTTGGAGTGAGTGAGCCTCCCGCACTGCTCAGGGGAGAGCTGGTGAGCATGACTCCATG
GCCTCCTGCTGGTTGGGGTCTTCTTCTGATTCTCACCCGCAGGAGCACCCAGACCCCCCCTTTTCAGAAATGATTACATTTTCCCTTCAA
GAGTCATCTGTGACCTGGTGGTGTGGAGGGACTGTCCCCTCCTGCAGCCTGGCCGACCCCCTTCCTCCAGGGCTGTGTGGAATCACCTCT
CAGAAGCTCACTCTGAAAAGCCACTCACAGGGATTTCACCAGGATGTTGCTGTTCCTGCCGACACCTGGGCTTTGTGACAAATGCTGTTT
GCTTCAAGCTGTTCACAAGCAACTTCACCAGAATCCCAAGCTGGTTCGTACTTAATTTGTGTACATACATATGCATAATATACATGACCA
TGTATGAGATACAGACACCATGGCTTCTGTCCATTGGCTCATTCGCCTGGTCGCATGTTCACTCCATGAGGTTAGGACACTGCGGGTGGC
TTTGGGATGGGTGGTTTCAGGGACAAGGTGTCGCTATGATCTCTGTATTTGCTAACTAGTCTTGTTTTGATTTCTAACGGTCTAGTGGAG
TACAGTTAATGTTGTGTTTATTTCTGTAACTGTAGGGGTGGAGTATAAACCTAACTTTTGGAAACATGAAGAAATAAACAATAGCGCCAG

>54671_54671_2_MPDZ-ITPK1_MPDZ_chr9_13247634_ENST00000381022_ITPK1_chr14_93408249_ENST00000267615_length(amino acids)=164AA_BP=
MSRDQRWSACTLRVRLASWAPSLPLPGAGPASLSRPLIADTPLASLGRVHRPPSPGCGWPLPTSHVAPRPLRSKSPSSISTLGKCSCPAH

--------------------------------------------------------------
>54671_54671_3_MPDZ-ITPK1_MPDZ_chr9_13247634_ENST00000447879_ITPK1_chr14_93408249_ENST00000267615_length(transcript)=5217nt_BP=226nt
TGCTGTTAATCATTTCAGAGAAGAACACTGAACTTTGAAAAAAATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCG
CTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAAGACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAG
TCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGACCAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCAC
ATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCACAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCG
GCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCGGCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAG
GCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCGGCTGCAACGCCGGCGTGTCGCCCAGCTTCCAGCAGCATTGTGTGGCC
TCCCTGGCCACCAAGGCCTCCTCCCAGTAGCCACGGAGCCGGGACCCAGAGGGGCAGCGCAGGGCGCAGAGCACACCCGCTGGGCCAGCA
GCTCCCAACGGCGATGCTACTACTAAGAATCCCCAGTGATCTGATTCTTCTGTTTTTTAATTTTTAACCTGATTCTCTGATGTCATGATC
TAAATGAGGGGTAGTGGGGGATGGAAGAGAGTACCAGGTGGTCCACCGTTGGGGAGTGGGGCCGTCCGCCTGCTCTCTACTGTGCAGACC
TCCTAACTGAGTTTACACACGCTTGTGTTTGCAACACTAGGTCTGGATGGGAGGTGAGGGGTGTGCGTATGGCTGCCATGCCAGTGTCTG
TGCACATCCCTGTCTGTTGGTCTCCATGGCCACTGTGGACCGGGACCCTTGGGGGAAGCCTGCCCATGTCGGGCTGTGGGAGGCTGATCG
GTGCATGTGAGAGTGGCTTCCCTTCTGCCTGACTCCCCACTCCCTGACCTGCCCCTTCCTTGTTTTTCCTCCTACTGGTCTCCACCAAGG
CTTTGTTAGCCCCCACCCTGCCTGGTGTGCAGCTAACCCCTCCCTCCCCACAGCCAGAGGAGGCCACAGACCCCTCAGGGGAGTTCCGCG
CTGGGGTCTGGGCTGTGCTCCCTCACTAAAGGGAAGGAAAGGAAGCTGGGCGTCCTCTGGGCCCCCCAACACACGTCCCATTTAGCCCTG
CACAGCGGTCTCCTTCCCCTAAGCCAGCACTGCTGCTCCCTGGAGCCCGGGAAGGAGGCTGCCTGGCTGGAGGCCCGAGCCGATGGCGCC
TGTGCTGAGGATTTGTGCTGTGATTTGGGCAAATCATTCCAGGTCTTTGGGCCTCCACCCCCTTGTCTCTAGTGGACATTTGAGATCAGA
GAGCACCACAGGGCTGGCTTTGTGCCCTAACCCCTGGGATGCAGCCTGCCTTTCCATAAAGTCACCTAGGTGAGGATAGGCGCGGGAGCC
TCGGCATGACACCATGGAGATCGGGGCCCTCTTCCCAGTGGGTTCACTCCTTTTCACACCTGCTGGGTCCCTCCTCACCCAGCAGGCCTG
GTCCACCTCTCATTGCAAGCCCCAAGCACTGAGCCAGCAGGTGCCAGGGAGCCACCCGCCCCCCATCGCTTCTGCACACCTCAGACTCAC
CCCATCACCTTGGCAGCAAAGCACTGGCTCTGCCGTCTGACCCCTGATCCAGGCAGCCCCCTCTGCAGAGAAAAGGGTTGGGGAGAAGCC
TCTGCAGTCCTGGAAGATGTGGGGTGCTGGGTGAGAGGCATCAGCCCCCACAAGTATGTTTTTGTGTCTTAAGATAGCAGTTTACTTTGA
AAAAGTGAAAAAGGCTTCCGGGCTGTCCTCTGCCCAGTGAGATGGAGGACGCTAGAGAAAGTGCTGAGTGTCCCGAGAGAGGCCCCCGAG
CCAGTGCATGGAGGTCCTTCGGCCTGGCTCAGCTGGGCTGCAGGATGCCCACTTTGAGGAGGGAGGCACAGGGCTTGGGCGAGGGGCAGA
GGCCATCAGAACTGCCCGGCTTTTTTGGAAACTGAGGACCCAACAACTAACCACGTTTACACGACTTGAGTTTTGAACCCCGATTAATGT
CTGTACGTCACCTTTCCTAGTTCTGACCCTGAGCCCTGGGGAACAGGAAAGCGTGGCTGGCCTCTTGCACTGCTTTGTCTCCAAAATAAA
CTACTGAAATCAAACCGCATTTCACACGTGTTTACACATGTTGCTCAAGTTTGTTATGTCATACTCCCAGTCCTTAAAAGACGTTTAATA
AAACAGCTTTACCTTTTAAAAATAAAATTTCAATCCCAGTCTGCCTCAGGTACGGGTGGGGGTGTGCAGCGTGACTCCTGGCTGTGTTCC
TGTACCGTTTGTGGCCTCCGGGGTCTTGCGCGTCCAGGGCCCAGATACCGAGTAACTGCCATGTGGTGTCGTGGTGGCGTCCATAGGCCT
CCGTGGTGGGGCGGGGGCGGGGCTGTGGGTGTGCAGGGCAGCTGCATTTTCCAAGAGTGGAGATGGAGGATGGAGATTTGCTTCGTAAAG
GCCTGGGAGCTACATGGGAGGTAGGGAGGGGCCAGCCACACCCAGGGCTGGGGGGCCGGTGGACTCTGCCCAGTGAAGCCAGGGGAGTGT
CAGCAATGAGGGGCCTGGACAGCGACGCGGGACCCGCACCTGGGAGCGGCAGAGATGGAGCCCAGCTCGCTAAACGTACCCTAAGGGTGC
ACGCTGACCATCTTTGATCCCTGGACAGTGTCCATAGAGTTGTCTCCCCTTCGGTCACATTGTCCCTGGCCTTGGAGTTTCTGCCTCAGG
GAAAGACCCACTAAAACCACCCGGGCTCTGGCGGCCTCCTCTTCTCCAGAGCATGGTGGCGCTGCCTCCTGAGCAGAGTCACTGAGAGTG
TCTGGGTCCAAGGAAGGGACCCACTTAGCAAAGGTTGTTGTGTGGTGCTGTGCAGGCACGGCGCCTGGAGTTGGCCCCGCCAGCATCGGG
GTGGCTTGGGGCTCTGGTTCCTAAGCTTCTGCTTCTGAGTTGGTCAGCACGTTGGCTCTGCGCCCTGCAGTGCCTGTCTTGATGGTGGTC
CCTGGATGTGCTGAAGGGCTCCAGGAGCAAGGGGCCAGACCACACTTTGGCTGAGTCCTTGGGTAGTTTCAGAGGGTCACCTGCACAGTC
TGCATTGAGCACCCTGGGGCTGAGGCCGTGGGTCAAGTTCTGCCTGACAGTGCTTTGATTATATGGTGATGTGATTCTGCAAACATAACC
CCCCAACTGAGTGCCAGCTGCTGGGTGTCCCCACCCCAAGAGCCAAGGGGAGGCCACCCTGGAACTGGTGCTTTGCCCTTGGTGTCATGG
AGGTGTCTGGGTCCACACGTGGTGGGTGGGCTGGGCCTGCAGTCACCCAGCATGGCCGGCGGGATTGGACCCAGCTGCAACCTGGCAGGT
TCCATGGGGCTTCCTGTGCCTGGGCCTGCCTGTGTCTCATGCCTGTCAATAAAGGAGAAAGCAACCTGGGAAAAACATTCCTCTCTGTAC
CCAGGGGACTGCCAAGTGTGCTTTATAGAAGGCTGGAAGACCGACTGAAGTAGGAAGCTGTCACATGTTTGAGCCAACTGAGCAAAGCAG
CTGTTGCCTGCCAGACAGCCACCCCAAGACCAAGGGAGCCAGCCTGTCGTTTGTCCTTCTAGCCTGGAAGACCAGTTCTTGGCTCTTGGG
CACTCACATTGGCCACTGGCCACAACTGCTGAATGGCTTCACTAATGTCCCTGGGGTCTGTATCTGCCCTCTCTTCTATTCCCTAGAAAC
TCTGGCCGGGCATGGCGGCTCACGCCTGTCATCCCAGCACTTAGGGAGGCTGAGGCAGGTGGATCACAAGGTCAAGAGATCGACACCATC
CTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGACATGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGA
GGCTGAGGCAGGAGAATTGCTTGAACTCGGGAGGCGTAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGCAACAGAGCA
AGACTCCTCAAAAAACAAACAAACAAACAAACAAACTCTGATCATTCACCCGGTGGGATCCCCGGCAGCTCCTTCTCCTTCCCGAGCTGT
GGCTCATGGGCCATTGGATTCAGAGACCTTGAGCTGGGTGCTGGCTGCCCTAAAGGAGCACGACCCCTCCAGCCTGGTGACCGGGAGGCA
GAGAAGTGCAGCTGTCCTTGACAAAGGCCCAGCCTCTGCTGCCTCAGGCCAGCCTGGCCACACCCCGATGCCACAGTCATCTGCCCCGCC
CAGGCATAAGCCTGACTCAGGTGATACAGGCGAGGCTTCTCCCATGGGTCCTCCCCTTGTGAGAAAGGGTCTGTGCTGTGTACCTTCTCT
CTGCACAGCCATTGTCAGTGTGGTTTGGAGTGAGTGAGCCTCCCGCACTGCTCAGGGGAGAGCTGGTGAGCATGACTCCATGGCCTCCTG
CTGGTTGGGGTCTTCTTCTGATTCTCACCCGCAGGAGCACCCAGACCCCCCCTTTTCAGAAATGATTACATTTTCCCTTCAAGAGTCATC
TGTGACCTGGTGGTGTGGAGGGACTGTCCCCTCCTGCAGCCTGGCCGACCCCCTTCCTCCAGGGCTGTGTGGAATCACCTCTCAGAAGCT
CACTCTGAAAAGCCACTCACAGGGATTTCACCAGGATGTTGCTGTTCCTGCCGACACCTGGGCTTTGTGACAAATGCTGTTTGCTTCAAG
CTGTTCACAAGCAACTTCACCAGAATCCCAAGCTGGTTCGTACTTAATTTGTGTACATACATATGCATAATATACATGACCATGTATGAG
ATACAGACACCATGGCTTCTGTCCATTGGCTCATTCGCCTGGTCGCATGTTCACTCCATGAGGTTAGGACACTGCGGGTGGCTTTGGGAT
GGGTGGTTTCAGGGACAAGGTGTCGCTATGATCTCTGTATTTGCTAACTAGTCTTGTTTTGATTTCTAACGGTCTAGTGGAGTACAGTTA

>54671_54671_3_MPDZ-ITPK1_MPDZ_chr9_13247634_ENST00000447879_ITPK1_chr14_93408249_ENST00000267615_length(amino acids)=164AA_BP=
MSRDQRWSACTLRVRLASWAPSLPLPGAGPASLSRPLIADTPLASLGRVHRPPSPGCGWPLPTSHVAPRPLRSKSPSSISTLGKCSCPAH

--------------------------------------------------------------
>54671_54671_4_MPDZ-ITPK1_MPDZ_chr9_13247634_ENST00000536827_ITPK1_chr14_93408249_ENST00000267615_length(transcript)=5217nt_BP=226nt
TGCTGTTAATCATTTCAGAGAAGAACACTGAACTTTGAAAAAAATGTTGGAAGCCATTGACAAAAATCGGGCCCTGCATGCAGCAGAGCG
CTTGCAAACCAAGCTGCGAGAACGTGGGGATGTAGCAAATGAAGACAAACTGAGCCTTCTGAAGTCAGTCCTGCAGAGCCCTCTCTTCAG
TCAGATTCTGAGCCTTCAGACTTCTGTACAGCAGCTGAAAGACCAGGCTACGAGGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCAC
ATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCACAGGGGACGTGGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCG
GCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCGGCTGCTGCGGCAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAG
GCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCGGCTGCAACGCCGGCGTGTCGCCCAGCTTCCAGCAGCATTGTGTGGCC
TCCCTGGCCACCAAGGCCTCCTCCCAGTAGCCACGGAGCCGGGACCCAGAGGGGCAGCGCAGGGCGCAGAGCACACCCGCTGGGCCAGCA
GCTCCCAACGGCGATGCTACTACTAAGAATCCCCAGTGATCTGATTCTTCTGTTTTTTAATTTTTAACCTGATTCTCTGATGTCATGATC
TAAATGAGGGGTAGTGGGGGATGGAAGAGAGTACCAGGTGGTCCACCGTTGGGGAGTGGGGCCGTCCGCCTGCTCTCTACTGTGCAGACC
TCCTAACTGAGTTTACACACGCTTGTGTTTGCAACACTAGGTCTGGATGGGAGGTGAGGGGTGTGCGTATGGCTGCCATGCCAGTGTCTG
TGCACATCCCTGTCTGTTGGTCTCCATGGCCACTGTGGACCGGGACCCTTGGGGGAAGCCTGCCCATGTCGGGCTGTGGGAGGCTGATCG
GTGCATGTGAGAGTGGCTTCCCTTCTGCCTGACTCCCCACTCCCTGACCTGCCCCTTCCTTGTTTTTCCTCCTACTGGTCTCCACCAAGG
CTTTGTTAGCCCCCACCCTGCCTGGTGTGCAGCTAACCCCTCCCTCCCCACAGCCAGAGGAGGCCACAGACCCCTCAGGGGAGTTCCGCG
CTGGGGTCTGGGCTGTGCTCCCTCACTAAAGGGAAGGAAAGGAAGCTGGGCGTCCTCTGGGCCCCCCAACACACGTCCCATTTAGCCCTG
CACAGCGGTCTCCTTCCCCTAAGCCAGCACTGCTGCTCCCTGGAGCCCGGGAAGGAGGCTGCCTGGCTGGAGGCCCGAGCCGATGGCGCC
TGTGCTGAGGATTTGTGCTGTGATTTGGGCAAATCATTCCAGGTCTTTGGGCCTCCACCCCCTTGTCTCTAGTGGACATTTGAGATCAGA
GAGCACCACAGGGCTGGCTTTGTGCCCTAACCCCTGGGATGCAGCCTGCCTTTCCATAAAGTCACCTAGGTGAGGATAGGCGCGGGAGCC
TCGGCATGACACCATGGAGATCGGGGCCCTCTTCCCAGTGGGTTCACTCCTTTTCACACCTGCTGGGTCCCTCCTCACCCAGCAGGCCTG
GTCCACCTCTCATTGCAAGCCCCAAGCACTGAGCCAGCAGGTGCCAGGGAGCCACCCGCCCCCCATCGCTTCTGCACACCTCAGACTCAC
CCCATCACCTTGGCAGCAAAGCACTGGCTCTGCCGTCTGACCCCTGATCCAGGCAGCCCCCTCTGCAGAGAAAAGGGTTGGGGAGAAGCC
TCTGCAGTCCTGGAAGATGTGGGGTGCTGGGTGAGAGGCATCAGCCCCCACAAGTATGTTTTTGTGTCTTAAGATAGCAGTTTACTTTGA
AAAAGTGAAAAAGGCTTCCGGGCTGTCCTCTGCCCAGTGAGATGGAGGACGCTAGAGAAAGTGCTGAGTGTCCCGAGAGAGGCCCCCGAG
CCAGTGCATGGAGGTCCTTCGGCCTGGCTCAGCTGGGCTGCAGGATGCCCACTTTGAGGAGGGAGGCACAGGGCTTGGGCGAGGGGCAGA
GGCCATCAGAACTGCCCGGCTTTTTTGGAAACTGAGGACCCAACAACTAACCACGTTTACACGACTTGAGTTTTGAACCCCGATTAATGT
CTGTACGTCACCTTTCCTAGTTCTGACCCTGAGCCCTGGGGAACAGGAAAGCGTGGCTGGCCTCTTGCACTGCTTTGTCTCCAAAATAAA
CTACTGAAATCAAACCGCATTTCACACGTGTTTACACATGTTGCTCAAGTTTGTTATGTCATACTCCCAGTCCTTAAAAGACGTTTAATA
AAACAGCTTTACCTTTTAAAAATAAAATTTCAATCCCAGTCTGCCTCAGGTACGGGTGGGGGTGTGCAGCGTGACTCCTGGCTGTGTTCC
TGTACCGTTTGTGGCCTCCGGGGTCTTGCGCGTCCAGGGCCCAGATACCGAGTAACTGCCATGTGGTGTCGTGGTGGCGTCCATAGGCCT
CCGTGGTGGGGCGGGGGCGGGGCTGTGGGTGTGCAGGGCAGCTGCATTTTCCAAGAGTGGAGATGGAGGATGGAGATTTGCTTCGTAAAG
GCCTGGGAGCTACATGGGAGGTAGGGAGGGGCCAGCCACACCCAGGGCTGGGGGGCCGGTGGACTCTGCCCAGTGAAGCCAGGGGAGTGT
CAGCAATGAGGGGCCTGGACAGCGACGCGGGACCCGCACCTGGGAGCGGCAGAGATGGAGCCCAGCTCGCTAAACGTACCCTAAGGGTGC
ACGCTGACCATCTTTGATCCCTGGACAGTGTCCATAGAGTTGTCTCCCCTTCGGTCACATTGTCCCTGGCCTTGGAGTTTCTGCCTCAGG
GAAAGACCCACTAAAACCACCCGGGCTCTGGCGGCCTCCTCTTCTCCAGAGCATGGTGGCGCTGCCTCCTGAGCAGAGTCACTGAGAGTG
TCTGGGTCCAAGGAAGGGACCCACTTAGCAAAGGTTGTTGTGTGGTGCTGTGCAGGCACGGCGCCTGGAGTTGGCCCCGCCAGCATCGGG
GTGGCTTGGGGCTCTGGTTCCTAAGCTTCTGCTTCTGAGTTGGTCAGCACGTTGGCTCTGCGCCCTGCAGTGCCTGTCTTGATGGTGGTC
CCTGGATGTGCTGAAGGGCTCCAGGAGCAAGGGGCCAGACCACACTTTGGCTGAGTCCTTGGGTAGTTTCAGAGGGTCACCTGCACAGTC
TGCATTGAGCACCCTGGGGCTGAGGCCGTGGGTCAAGTTCTGCCTGACAGTGCTTTGATTATATGGTGATGTGATTCTGCAAACATAACC
CCCCAACTGAGTGCCAGCTGCTGGGTGTCCCCACCCCAAGAGCCAAGGGGAGGCCACCCTGGAACTGGTGCTTTGCCCTTGGTGTCATGG
AGGTGTCTGGGTCCACACGTGGTGGGTGGGCTGGGCCTGCAGTCACCCAGCATGGCCGGCGGGATTGGACCCAGCTGCAACCTGGCAGGT
TCCATGGGGCTTCCTGTGCCTGGGCCTGCCTGTGTCTCATGCCTGTCAATAAAGGAGAAAGCAACCTGGGAAAAACATTCCTCTCTGTAC
CCAGGGGACTGCCAAGTGTGCTTTATAGAAGGCTGGAAGACCGACTGAAGTAGGAAGCTGTCACATGTTTGAGCCAACTGAGCAAAGCAG
CTGTTGCCTGCCAGACAGCCACCCCAAGACCAAGGGAGCCAGCCTGTCGTTTGTCCTTCTAGCCTGGAAGACCAGTTCTTGGCTCTTGGG
CACTCACATTGGCCACTGGCCACAACTGCTGAATGGCTTCACTAATGTCCCTGGGGTCTGTATCTGCCCTCTCTTCTATTCCCTAGAAAC
TCTGGCCGGGCATGGCGGCTCACGCCTGTCATCCCAGCACTTAGGGAGGCTGAGGCAGGTGGATCACAAGGTCAAGAGATCGACACCATC
CTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGACATGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGA
GGCTGAGGCAGGAGAATTGCTTGAACTCGGGAGGCGTAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGCAACAGAGCA
AGACTCCTCAAAAAACAAACAAACAAACAAACAAACTCTGATCATTCACCCGGTGGGATCCCCGGCAGCTCCTTCTCCTTCCCGAGCTGT
GGCTCATGGGCCATTGGATTCAGAGACCTTGAGCTGGGTGCTGGCTGCCCTAAAGGAGCACGACCCCTCCAGCCTGGTGACCGGGAGGCA
GAGAAGTGCAGCTGTCCTTGACAAAGGCCCAGCCTCTGCTGCCTCAGGCCAGCCTGGCCACACCCCGATGCCACAGTCATCTGCCCCGCC
CAGGCATAAGCCTGACTCAGGTGATACAGGCGAGGCTTCTCCCATGGGTCCTCCCCTTGTGAGAAAGGGTCTGTGCTGTGTACCTTCTCT
CTGCACAGCCATTGTCAGTGTGGTTTGGAGTGAGTGAGCCTCCCGCACTGCTCAGGGGAGAGCTGGTGAGCATGACTCCATGGCCTCCTG
CTGGTTGGGGTCTTCTTCTGATTCTCACCCGCAGGAGCACCCAGACCCCCCCTTTTCAGAAATGATTACATTTTCCCTTCAAGAGTCATC
TGTGACCTGGTGGTGTGGAGGGACTGTCCCCTCCTGCAGCCTGGCCGACCCCCTTCCTCCAGGGCTGTGTGGAATCACCTCTCAGAAGCT
CACTCTGAAAAGCCACTCACAGGGATTTCACCAGGATGTTGCTGTTCCTGCCGACACCTGGGCTTTGTGACAAATGCTGTTTGCTTCAAG
CTGTTCACAAGCAACTTCACCAGAATCCCAAGCTGGTTCGTACTTAATTTGTGTACATACATATGCATAATATACATGACCATGTATGAG
ATACAGACACCATGGCTTCTGTCCATTGGCTCATTCGCCTGGTCGCATGTTCACTCCATGAGGTTAGGACACTGCGGGTGGCTTTGGGAT
GGGTGGTTTCAGGGACAAGGTGTCGCTATGATCTCTGTATTTGCTAACTAGTCTTGTTTTGATTTCTAACGGTCTAGTGGAGTACAGTTA

>54671_54671_4_MPDZ-ITPK1_MPDZ_chr9_13247634_ENST00000536827_ITPK1_chr14_93408249_ENST00000267615_length(amino acids)=164AA_BP=
MSRDQRWSACTLRVRLASWAPSLPLPGAGPASLSRPLIADTPLASLGRVHRPPSPGCGWPLPTSHVAPRPLRSKSPSSISTLGKCSCPAH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MPDZ-ITPK1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MPDZ-ITPK1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MPDZ-ITPK1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source