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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MPHOSPH9-ELK3 (FusionGDB2 ID:54704) |
Fusion Gene Summary for MPHOSPH9-ELK3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MPHOSPH9-ELK3 | Fusion gene ID: 54704 | Hgene | Tgene | Gene symbol | MPHOSPH9 | ELK3 | Gene ID | 10198 | 2004 |
| Gene name | M-phase phosphoprotein 9 | ETS transcription factor ELK3 | |
| Synonyms | MPP-9|MPP9 | ERP|NET|SAP-2|SAP2 | |
| Cytomap | 12q24.31 | 12q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | M-phase phosphoprotein 9 | ETS domain-containing protein Elk-3ELK3, ETS transcription factorELK3, ETS-domain protein (SRF accessory protein 2)ETS-related protein ERPETS-related protein NETSRF accessory protein 2serum response factor accessory protein 2 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q99550 | P41970 | |
| Ensembl transtripts involved in fusion gene | ENST00000302349, ENST00000392425, ENST00000541076, ENST00000606320, ENST00000539639, | ENST00000549529, ENST00000552142, ENST00000228741, | |
| Fusion gene scores | * DoF score | 14 X 13 X 8=1456 | 24 X 8 X 11=2112 |
| # samples | 13 | 22 | |
| ** MAII score | log2(13/1456*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(22/2112*10)=-3.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MPHOSPH9 [Title/Abstract] AND ELK3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MPHOSPH9(123694603)-ELK3(96640718), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | MPHOSPH9-ELK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MPHOSPH9-ELK3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ELK3 | GO:0045892 | negative regulation of transcription, DNA-templated | 12933792 |
| Tgene | ELK3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12788937 |
| Fusion gene breakpoints across MPHOSPH9 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ELK3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-DX-A3LS-01A | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + |
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Fusion Gene ORF analysis for MPHOSPH9-ELK3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000302349 | ENST00000549529 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + |
| 5CDS-intron | ENST00000302349 | ENST00000552142 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + |
| 5CDS-intron | ENST00000392425 | ENST00000549529 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + |
| 5CDS-intron | ENST00000392425 | ENST00000552142 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + |
| 5CDS-intron | ENST00000541076 | ENST00000549529 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + |
| 5CDS-intron | ENST00000541076 | ENST00000552142 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + |
| 5CDS-intron | ENST00000606320 | ENST00000549529 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + |
| 5CDS-intron | ENST00000606320 | ENST00000552142 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + |
| Frame-shift | ENST00000606320 | ENST00000228741 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + |
| In-frame | ENST00000302349 | ENST00000228741 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + |
| In-frame | ENST00000392425 | ENST00000228741 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + |
| In-frame | ENST00000541076 | ENST00000228741 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + |
| intron-3CDS | ENST00000539639 | ENST00000228741 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + |
| intron-intron | ENST00000539639 | ENST00000549529 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + |
| intron-intron | ENST00000539639 | ENST00000552142 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000302349 | MPHOSPH9 | chr12 | 123694603 | - | ENST00000228741 | ELK3 | chr12 | 96640718 | + | 4517 | 845 | 107 | 1861 | 584 |
| ENST00000541076 | MPHOSPH9 | chr12 | 123694603 | - | ENST00000228741 | ELK3 | chr12 | 96640718 | + | 4858 | 1186 | 73 | 2202 | 709 |
| ENST00000392425 | MPHOSPH9 | chr12 | 123694603 | - | ENST00000228741 | ELK3 | chr12 | 96640718 | + | 4517 | 845 | 107 | 1861 | 584 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000302349 | ENST00000228741 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + | 0.000578424 | 0.9994216 |
| ENST00000541076 | ENST00000228741 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + | 0.000190062 | 0.9998099 |
| ENST00000392425 | ENST00000228741 | MPHOSPH9 | chr12 | 123694603 | - | ELK3 | chr12 | 96640718 | + | 0.000578424 | 0.9994216 |
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Fusion Genomic Features for MPHOSPH9-ELK3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MPHOSPH9-ELK3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:123694603/chr12:96640718) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MPHOSPH9 | ELK3 |
| FUNCTION: May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ELK3 | chr12:123694603 | chr12:96640718 | ENST00000228741 | 1 | 5 | 207_212 | 69 | 408.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | ELK3 | chr12:123694603 | chr12:96640718 | ENST00000228741 | 1 | 5 | 273_277 | 69 | 408.0 | Motif | Note=CTBP-binding motif |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MPHOSPH9 | chr12:123694603 | chr12:96640718 | ENST00000302349 | - | 4 | 20 | 1109_1174 | 246 | 1029.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | MPHOSPH9 | chr12:123694603 | chr12:96640718 | ENST00000302349 | - | 4 | 20 | 609_804 | 246 | 1029.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | MPHOSPH9 | chr12:123694603 | chr12:96640718 | ENST00000392425 | - | 4 | 20 | 1109_1174 | 246 | 1032.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | MPHOSPH9 | chr12:123694603 | chr12:96640718 | ENST00000392425 | - | 4 | 20 | 609_804 | 246 | 1032.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | ELK3 | chr12:123694603 | chr12:96640718 | ENST00000228741 | 1 | 5 | 5_85 | 69 | 408.0 | DNA binding | ETS |
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Fusion Gene Sequence for MPHOSPH9-ELK3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >54704_54704_1_MPHOSPH9-ELK3_MPHOSPH9_chr12_123694603_ENST00000302349_ELK3_chr12_96640718_ENST00000228741_length(transcript)=4517nt_BP=845nt ATATACAGGAGGAGATAAAAAATTTAGTCAAATTACAGACTAGTAGTGCTTCCTTAGCTTCCTGTGAAGGAAATTCTTCAAACAAACAAG TATCTTCGGAAAGTCAAATGGGTTTTTTTTCTCTAAGCAGTGAGAGAAATGAATCTGTTATCCATTATCCTGAATCCACAGAACCTGAAA TACAGCAAGAAATGTCCACGTCACAACCAGACTGCAATGTGGATAGTTGCTCAGTAAGCAGTGGATATGGCACCTTTTGTATCTCAGAAT TAAATCTGTACAAATCTAAAGACCCTAAGGAGTTCATGGAGCACATAGATGTTCCCAAAGGACAGTATGTAGCACCTGCGGTGCCGGCTG AGTCACTTGTAGATGGTGTGAAAAATGAGAATTTTTATATACAGACTCCTGAAGAGTGTCATGTGTCTTTAAAGGAAGATGTATCCATTT CTCCTGGTGAATTTGAACATAATTTTCTTGGTGAAAATAAGGTTTCTGAAGTATACAGTGGGAAAACAAATAGTAATGCTATAACATCAT GGGCACAAAAACTGAAGCAGAACCAACCAAAGAGAGCACATGTAGAAGATGGAGGTTCAAGATCTAAACAAGGAAATGAGCAAAGTAAGA AGACACCAATTGAGAAATCTGATTTTGCTGCTGCTACACATCCTCGTGCTTTTTACCTCAGTAAACCAGATGAAACTCCAAATGCTTGGA TGTCTGATTCAGGAACAGGATTGACTTACTGGAAACTAGAGGAAAAGGATATGCACCACTCTTTGCCTGAAACTTTAGAGAAGACGTTCA TATCATTGTCTTCCACAGATGTGTCACCAAACCAGAACATCATCAAGAAGGTGATCGGGCAGAAGTTTGTGTACAAGTTTGTCTCTTTCC CGGAGATCCTGAAGATGGATCCTCACGCGGTGGAGATCAGCCGGGAGAGCCTTCTGCTGCAGGACAGCGACTGCAAGGCGTCTCCGGAGG GCCGCGAGGCCCACAAACACGGCCTGGCCGCCCTCAGAAGCACGAGCCGCAACGAATACATCCACTCAGGCCTGTACTCGTCCTTCACCA TTAATTCCCTGCAGAACCCACCAGACGCCTTCAAGGCCATCAAGACGGAGAAGCTGGAGGAGCCGCCCGAAGACAGCCCCCCCGTGGAAG AAGTCAGGACTGTGATCAGGTTTGTGACCAATAAAACCGACAAGCACGTCACCAGGCCGGTGGTGTCCCTGCCTTCCACGTCAGAGGCTG CGGCGGCGTCCGCCTTCCTGGCCTCGTCCGTCTCGGCCAAGATCTCCTCTTTAATGTTGCCAAACGCTGCCAGTATTTCATCCGCCTCAC CCTTCTCATCTCGGTCCCCGTCCCTGTCCCCCAACTCACCCCTCCCTTCTGAACACAGAAGCCTCTTCCTGGAGGCCGCCTGCCATGACT CCGATTCCCTGGAGCCCTTGAACCTGTCATCGGGCTCCAAGACCAAGTCTCCATCTCTTCCCCCAAAGGCCAAAAAACCCAAAGGCTTGG AAATCTCAGCGCCCCCGCTGGTGCTCTCCGGCACCGACATCGGCTCCATCGCCCTCAACAGCCCAGCCCTCCCCTCGGGATCCCTCACCC CAGCCTTCTTCACCGCACAGACACCAAATGGATTGCTTCTGACTCCGAGTCCACTGCTCTCCAGCATACATTTCTGGAGCAGCCTTAGTC CAGTTGCTCCGCTGAGTCCTGCCAGGCTGCAAGGGCCAAGCACGCTGTTCCAGTTCCCCACACTGCTTAATGGCCACATGCCAGTGCCAA TCCCCAGTCTGGACAGAGCTGCTTCTCCAGTACTGCTTTCTTCAAACTCTCAGAAATCCTGATGACGTCTGGCCACAATTAAGGACTCAT TAACTGATGAAACAAATTTGTCCCCACGGGCTAGTTTACCTGTGTCGTGAGAAGGACATTGTGAAACTCTTGTTAATTTGGTTTGCACTT TTCATAACATGGATAGTCTAGATTTATGTTAGCATTTTAAAAACTGTTTTTGATATATTCAAGTATATATGAAAATCTGTTTGGCATTAA GTGAATTTTAATGTTTTTGTTTTTATATCCTTTTAGCTCTTAAGTGTTGAACACTGTTGACAGTGAAGAACTTTTCTTAATGGTTTTCAG TATAACTAATAAGGATGTGAAGCTTTTTTCTCTTTAGTTCTGAGTATGCTAAACTGTGTGCTTATATAGACTATAACCAGTTGTGCCTTC CTTCGCATTTAATGTAAATGAATGATTTATATATTTTTTAGTATTAAGAGGAAATGTTTGAAAGATGAAAATTAGTATCAAACAGCTCTC TAGTAGAATTTCATTATTTTTCACCAGTGGGCAATATGAAAGCATATATCACGTTTTGTTTTACTTTCAATTGTATAAGAATTGCCTTAG AACCTCTTTTGAACTGAAATTCAGTAAATGTCCAAGTAATGTTTTTATAATAAACTAAGCCATATTTAGACAATAAACATTGATAAAAGA AAATGTTCTAAAGTACATTTTCAAAAGAATGGACCTTGAAAGGCTAGCCTCCTTAGCTGTTTACAGTATCTTATCTTTTAGATGCCTCCC AGACAAAAATCTGAGATGGAAAAGCTACATCAAGTTCATGCTATTCCAGGCCCAAGAATATCTCCTAGGTTAGCATATTCTTATTTCAAA AAATTAGCCCTGGTTTTCTCAGTTTTCCATAGGGAATCCCGACCATCTGATATATTTACTGTGTCAGTATAAGTAAGTTGGGGTTCCCCT GGAACTATAATTAACATTTAAAAAATCTAATGCTTTAGAAGAAGCTCACAGAGTGGTGATGAACCCAAACAACAAAGAAACCATTTTTAA CACTAGGTATCTTCATCAGTATAGGTAGGTGTTCACAATTTTTGATGGATCAAAAACTTGCTGTAATACAAATAGAGAGTGGAGGTACTA AAGGCCTTGCTTGTGGAAACTGAGAGAGGATACACTGCTTTATGTATTACTAAAGTTAGGGGAGAATGAAGGAAATCTGACAGATGAAAA ATTCTACAGGAACCTCATCATCGTGGAACTGAACTGATGATAACTTGGAACACTCCAGTAAATTCTGTTGTGTAATGTAATTTGGAGCAG TGATAATACAGACATATTTTCTGTTCCATCAGAAAATCAGCAGGCACCAGTCCAAAGGTACCACACCTGTACATGAAGAAGGAAAGTTCT AATACAAGAAAACTGAAAAGCACCAAGCTTTAAATTCAAGATTAATTACAATCCTTAACTATAAGTGATGATAAAAACTAACTTGAAATG TGACTAAATAACTGATCCAAACTGGGCATTAAGTGGCAGGATTATGAGAAAGGATAAAAAAAGAGATTTGAGAAAACACATTTCTTGAAT TTTCAGAAAAAAATCTAGACTATTGCTTTGACACTTAGAAATTCTGAGGTTTTTCAATTGGAATTGAGCATCTCTGTATGTGGGGATGTG GGCCCTTATCAAGGGATAAAAATCCAAACACTCTAACATGCCTCCTTGACTGTAAAGTAATGACACTGGTTCCAAAATTCACAAATAATA GACACTACTGTCCCCCCACCCCCACCCCATAGGCTAAGAATAATTCTGTACCAGAATAAAAGGAGCTGGTCCAGGGAACTGATATTTACT GAACATACAAAGTTAGTGCTAGAAGGGGCCTTTGAGAATGCTTCCCGCCACCTGTTTCCAGCTCAAGACAGGTGCACAGCAGAAGCTGGG AGTTGCCTATGGCTGCACAGCTCACTGAAGGTAGAACAATGATTGGTGCTCAGTCCAATTCTGTCTCCCCCATGCCTAGCTGTTAAGTAA TTACTGGTTCAAAACTACGTGTTATTAGTAAAACAAACAAAACAGATAAAGACAGCATTTAAAACTGTGTTGTCAGATAAGAGAACACAT CCAAAATGCATGATTCTTACAAACTAAAGGAAGTTAATGTGCAAAAATCTCAACCAAAACTACTATTTTTAGTATACTTGTTTACGTAAA TGCTGATTGGAAATATTTAAATGACTATAGATCTGATTCTTTCTTTTCCTTTGGAAACTGGGATTAATGTATGCTCTAGATCCATTTATT AGAAATGCAAAAATACTACAATTTTTTGATGGATGAAAATACTCCTGTAACACAAACAGAGAACTGGAGGAACTGAAGAATAACTCACTC ATATAGCTCTGCCTCATTCTGTGTGTGTGTGCATGTGTGTGTTAGCAGAGGTATTTTACTCAGAAAATAGGTTTCAAAGAACATTAATGA CTTTCTTTTCCCTTTTATGTCTGCTTAATCAGTGTTAAACTGCTATGGGAAAAGTTTTATAGAACTATATAACCTGAATGTTGGTCTCTT TGTACACATCTTTTCTATGACTGCAAATCTTCACTTTATGTATCATTTTTACTGTCATATTATTTTTGTTCAATAAAAACTTTGTGATAA >54704_54704_1_MPHOSPH9-ELK3_MPHOSPH9_chr12_123694603_ENST00000302349_ELK3_chr12_96640718_ENST00000228741_length(amino acids)=584AA_BP=245 MGFFSLSSERNESVIHYPESTEPEIQQEMSTSQPDCNVDSCSVSSGYGTFCISELNLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDG VKNENFYIQTPEECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSWAQKLKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEK SDFAAATHPRAFYLSKPDETPNAWMSDSGTGLTYWKLEEKDMHHSLPETLEKTFISLSSTDVSPNQNIIKKVIGQKFVYKFVSFPEILKM DPHAVEISRESLLLQDSDCKASPEGREAHKHGLAALRSTSRNEYIHSGLYSSFTINSLQNPPDAFKAIKTEKLEEPPEDSPPVEEVRTVI RFVTNKTDKHVTRPVVSLPSTSEAAAASAFLASSVSAKISSLMLPNAASISSASPFSSRSPSLSPNSPLPSEHRSLFLEAACHDSDSLEP LNLSSGSKTKSPSLPPKAKKPKGLEISAPPLVLSGTDIGSIALNSPALPSGSLTPAFFTAQTPNGLLLTPSPLLSSIHFWSSLSPVAPLS -------------------------------------------------------------- >54704_54704_2_MPHOSPH9-ELK3_MPHOSPH9_chr12_123694603_ENST00000392425_ELK3_chr12_96640718_ENST00000228741_length(transcript)=4517nt_BP=845nt ATATACAGGAGGAGATAAAAAATTTAGTCAAATTACAGACTAGTAGTGCTTCCTTAGCTTCCTGTGAAGGAAATTCTTCAAACAAACAAG TATCTTCGGAAAGTCAAATGGGTTTTTTTTCTCTAAGCAGTGAGAGAAATGAATCTGTTATCCATTATCCTGAATCCACAGAACCTGAAA TACAGCAAGAAATGTCCACGTCACAACCAGACTGCAATGTGGATAGTTGCTCAGTAAGCAGTGGATATGGCACCTTTTGTATCTCAGAAT TAAATCTGTACAAATCTAAAGACCCTAAGGAGTTCATGGAGCACATAGATGTTCCCAAAGGACAGTATGTAGCACCTGCGGTGCCGGCTG AGTCACTTGTAGATGGTGTGAAAAATGAGAATTTTTATATACAGACTCCTGAAGAGTGTCATGTGTCTTTAAAGGAAGATGTATCCATTT CTCCTGGTGAATTTGAACATAATTTTCTTGGTGAAAATAAGGTTTCTGAAGTATACAGTGGGAAAACAAATAGTAATGCTATAACATCAT GGGCACAAAAACTGAAGCAGAACCAACCAAAGAGAGCACATGTAGAAGATGGAGGTTCAAGATCTAAACAAGGAAATGAGCAAAGTAAGA AGACACCAATTGAGAAATCTGATTTTGCTGCTGCTACACATCCTCGTGCTTTTTACCTCAGTAAACCAGATGAAACTCCAAATGCTTGGA TGTCTGATTCAGGAACAGGATTGACTTACTGGAAACTAGAGGAAAAGGATATGCACCACTCTTTGCCTGAAACTTTAGAGAAGACGTTCA TATCATTGTCTTCCACAGATGTGTCACCAAACCAGAACATCATCAAGAAGGTGATCGGGCAGAAGTTTGTGTACAAGTTTGTCTCTTTCC CGGAGATCCTGAAGATGGATCCTCACGCGGTGGAGATCAGCCGGGAGAGCCTTCTGCTGCAGGACAGCGACTGCAAGGCGTCTCCGGAGG GCCGCGAGGCCCACAAACACGGCCTGGCCGCCCTCAGAAGCACGAGCCGCAACGAATACATCCACTCAGGCCTGTACTCGTCCTTCACCA TTAATTCCCTGCAGAACCCACCAGACGCCTTCAAGGCCATCAAGACGGAGAAGCTGGAGGAGCCGCCCGAAGACAGCCCCCCCGTGGAAG AAGTCAGGACTGTGATCAGGTTTGTGACCAATAAAACCGACAAGCACGTCACCAGGCCGGTGGTGTCCCTGCCTTCCACGTCAGAGGCTG CGGCGGCGTCCGCCTTCCTGGCCTCGTCCGTCTCGGCCAAGATCTCCTCTTTAATGTTGCCAAACGCTGCCAGTATTTCATCCGCCTCAC CCTTCTCATCTCGGTCCCCGTCCCTGTCCCCCAACTCACCCCTCCCTTCTGAACACAGAAGCCTCTTCCTGGAGGCCGCCTGCCATGACT CCGATTCCCTGGAGCCCTTGAACCTGTCATCGGGCTCCAAGACCAAGTCTCCATCTCTTCCCCCAAAGGCCAAAAAACCCAAAGGCTTGG AAATCTCAGCGCCCCCGCTGGTGCTCTCCGGCACCGACATCGGCTCCATCGCCCTCAACAGCCCAGCCCTCCCCTCGGGATCCCTCACCC CAGCCTTCTTCACCGCACAGACACCAAATGGATTGCTTCTGACTCCGAGTCCACTGCTCTCCAGCATACATTTCTGGAGCAGCCTTAGTC CAGTTGCTCCGCTGAGTCCTGCCAGGCTGCAAGGGCCAAGCACGCTGTTCCAGTTCCCCACACTGCTTAATGGCCACATGCCAGTGCCAA TCCCCAGTCTGGACAGAGCTGCTTCTCCAGTACTGCTTTCTTCAAACTCTCAGAAATCCTGATGACGTCTGGCCACAATTAAGGACTCAT TAACTGATGAAACAAATTTGTCCCCACGGGCTAGTTTACCTGTGTCGTGAGAAGGACATTGTGAAACTCTTGTTAATTTGGTTTGCACTT TTCATAACATGGATAGTCTAGATTTATGTTAGCATTTTAAAAACTGTTTTTGATATATTCAAGTATATATGAAAATCTGTTTGGCATTAA GTGAATTTTAATGTTTTTGTTTTTATATCCTTTTAGCTCTTAAGTGTTGAACACTGTTGACAGTGAAGAACTTTTCTTAATGGTTTTCAG TATAACTAATAAGGATGTGAAGCTTTTTTCTCTTTAGTTCTGAGTATGCTAAACTGTGTGCTTATATAGACTATAACCAGTTGTGCCTTC CTTCGCATTTAATGTAAATGAATGATTTATATATTTTTTAGTATTAAGAGGAAATGTTTGAAAGATGAAAATTAGTATCAAACAGCTCTC TAGTAGAATTTCATTATTTTTCACCAGTGGGCAATATGAAAGCATATATCACGTTTTGTTTTACTTTCAATTGTATAAGAATTGCCTTAG AACCTCTTTTGAACTGAAATTCAGTAAATGTCCAAGTAATGTTTTTATAATAAACTAAGCCATATTTAGACAATAAACATTGATAAAAGA AAATGTTCTAAAGTACATTTTCAAAAGAATGGACCTTGAAAGGCTAGCCTCCTTAGCTGTTTACAGTATCTTATCTTTTAGATGCCTCCC AGACAAAAATCTGAGATGGAAAAGCTACATCAAGTTCATGCTATTCCAGGCCCAAGAATATCTCCTAGGTTAGCATATTCTTATTTCAAA AAATTAGCCCTGGTTTTCTCAGTTTTCCATAGGGAATCCCGACCATCTGATATATTTACTGTGTCAGTATAAGTAAGTTGGGGTTCCCCT GGAACTATAATTAACATTTAAAAAATCTAATGCTTTAGAAGAAGCTCACAGAGTGGTGATGAACCCAAACAACAAAGAAACCATTTTTAA CACTAGGTATCTTCATCAGTATAGGTAGGTGTTCACAATTTTTGATGGATCAAAAACTTGCTGTAATACAAATAGAGAGTGGAGGTACTA AAGGCCTTGCTTGTGGAAACTGAGAGAGGATACACTGCTTTATGTATTACTAAAGTTAGGGGAGAATGAAGGAAATCTGACAGATGAAAA ATTCTACAGGAACCTCATCATCGTGGAACTGAACTGATGATAACTTGGAACACTCCAGTAAATTCTGTTGTGTAATGTAATTTGGAGCAG TGATAATACAGACATATTTTCTGTTCCATCAGAAAATCAGCAGGCACCAGTCCAAAGGTACCACACCTGTACATGAAGAAGGAAAGTTCT AATACAAGAAAACTGAAAAGCACCAAGCTTTAAATTCAAGATTAATTACAATCCTTAACTATAAGTGATGATAAAAACTAACTTGAAATG TGACTAAATAACTGATCCAAACTGGGCATTAAGTGGCAGGATTATGAGAAAGGATAAAAAAAGAGATTTGAGAAAACACATTTCTTGAAT TTTCAGAAAAAAATCTAGACTATTGCTTTGACACTTAGAAATTCTGAGGTTTTTCAATTGGAATTGAGCATCTCTGTATGTGGGGATGTG GGCCCTTATCAAGGGATAAAAATCCAAACACTCTAACATGCCTCCTTGACTGTAAAGTAATGACACTGGTTCCAAAATTCACAAATAATA GACACTACTGTCCCCCCACCCCCACCCCATAGGCTAAGAATAATTCTGTACCAGAATAAAAGGAGCTGGTCCAGGGAACTGATATTTACT GAACATACAAAGTTAGTGCTAGAAGGGGCCTTTGAGAATGCTTCCCGCCACCTGTTTCCAGCTCAAGACAGGTGCACAGCAGAAGCTGGG AGTTGCCTATGGCTGCACAGCTCACTGAAGGTAGAACAATGATTGGTGCTCAGTCCAATTCTGTCTCCCCCATGCCTAGCTGTTAAGTAA TTACTGGTTCAAAACTACGTGTTATTAGTAAAACAAACAAAACAGATAAAGACAGCATTTAAAACTGTGTTGTCAGATAAGAGAACACAT CCAAAATGCATGATTCTTACAAACTAAAGGAAGTTAATGTGCAAAAATCTCAACCAAAACTACTATTTTTAGTATACTTGTTTACGTAAA TGCTGATTGGAAATATTTAAATGACTATAGATCTGATTCTTTCTTTTCCTTTGGAAACTGGGATTAATGTATGCTCTAGATCCATTTATT AGAAATGCAAAAATACTACAATTTTTTGATGGATGAAAATACTCCTGTAACACAAACAGAGAACTGGAGGAACTGAAGAATAACTCACTC ATATAGCTCTGCCTCATTCTGTGTGTGTGTGCATGTGTGTGTTAGCAGAGGTATTTTACTCAGAAAATAGGTTTCAAAGAACATTAATGA CTTTCTTTTCCCTTTTATGTCTGCTTAATCAGTGTTAAACTGCTATGGGAAAAGTTTTATAGAACTATATAACCTGAATGTTGGTCTCTT TGTACACATCTTTTCTATGACTGCAAATCTTCACTTTATGTATCATTTTTACTGTCATATTATTTTTGTTCAATAAAAACTTTGTGATAA >54704_54704_2_MPHOSPH9-ELK3_MPHOSPH9_chr12_123694603_ENST00000392425_ELK3_chr12_96640718_ENST00000228741_length(amino acids)=584AA_BP=245 MGFFSLSSERNESVIHYPESTEPEIQQEMSTSQPDCNVDSCSVSSGYGTFCISELNLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDG VKNENFYIQTPEECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSWAQKLKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEK SDFAAATHPRAFYLSKPDETPNAWMSDSGTGLTYWKLEEKDMHHSLPETLEKTFISLSSTDVSPNQNIIKKVIGQKFVYKFVSFPEILKM DPHAVEISRESLLLQDSDCKASPEGREAHKHGLAALRSTSRNEYIHSGLYSSFTINSLQNPPDAFKAIKTEKLEEPPEDSPPVEEVRTVI RFVTNKTDKHVTRPVVSLPSTSEAAAASAFLASSVSAKISSLMLPNAASISSASPFSSRSPSLSPNSPLPSEHRSLFLEAACHDSDSLEP LNLSSGSKTKSPSLPPKAKKPKGLEISAPPLVLSGTDIGSIALNSPALPSGSLTPAFFTAQTPNGLLLTPSPLLSSIHFWSSLSPVAPLS -------------------------------------------------------------- >54704_54704_3_MPHOSPH9-ELK3_MPHOSPH9_chr12_123694603_ENST00000541076_ELK3_chr12_96640718_ENST00000228741_length(transcript)=4858nt_BP=1186nt GAAGATGACACGGATTCATTTTTCTCAAACAGCCCAAGAACCTTTATTTTCCAATAAGAGAATATAACAATTTCTGTACACTATGGAAGA GTTTGACTTGGTGAAAACCTTACACAAAACTTCATCTTCTGTAGGATCTGATGAAAATTCTCTTCATTCTCTTGGACTGAACTTAAATAC TGATAGAAGTAGTCCCCACCTTAGTACAAATGGGGTATCCTCTTTCTCAGGGAAGACCAGACCATCTGTAATTCAAGGTACAGTTGAAGT CCTAACTTCTTTAATGCAAGAGCTACAAAACAGTGGAAAGACTGATTCGGAACTTTGGAAAAACTGTGAGCATATACAGGAGGAGATAAA AAATTTAGTCAAATTACAGACTAGTAGTGCTTCCTTAGCTTCCTGTGAAGGAAATTCTTCAAACAAACAAGTATCTTCGGAAAGTCAAAT GGGTTTTTTTTCTCTAAGCAGTGAGAGAAATGAATCTGTTATCCATTATCCTGAATCCACAGAACCTGAAATACAGCAAGAAATGTCCAC GTCACAACCAGACTGCAATGTGGATAGTTGCTCAGTAAGCAGTGGATATGGCACCTTTTGTATCTCAGAATTAAATCTGTACAAATCTAA AGACCCTAAGGAGTTCATGGAGCACATAGATGTTCCCAAAGGACAGTATGTAGCACCTGCGGTGCCGGCTGAGTCACTTGTAGATGGTGT GAAAAATGAGAATTTTTATATACAGACTCCTGAAGAGTGTCATGTGTCTTTAAAGGAAGATGTATCCATTTCTCCTGGTGAATTTGAACA TAATTTTCTTGGTGAAAATAAGGTTTCTGAAGTATACAGTGGGAAAACAAATAGTAATGCTATAACATCATGGGCACAAAAACTGAAGCA GAACCAACCAAAGAGAGCACATGTAGAAGATGGAGGTTCAAGATCTAAACAAGGAAATGAGCAAAGTAAGAAGACACCAATTGAGAAATC TGATTTTGCTGCTGCTACACATCCTCGTGCTTTTTACCTCAGTAAACCAGATGAAACTCCAAATGCTTGGATGTCTGATTCAGGAACAGG ATTGACTTACTGGAAACTAGAGGAAAAGGATATGCACCACTCTTTGCCTGAAACTTTAGAGAAGACGTTCATATCATTGTCTTCCACAGA TGTGTCACCAAACCAGAACATCATCAAGAAGGTGATCGGGCAGAAGTTTGTGTACAAGTTTGTCTCTTTCCCGGAGATCCTGAAGATGGA TCCTCACGCGGTGGAGATCAGCCGGGAGAGCCTTCTGCTGCAGGACAGCGACTGCAAGGCGTCTCCGGAGGGCCGCGAGGCCCACAAACA CGGCCTGGCCGCCCTCAGAAGCACGAGCCGCAACGAATACATCCACTCAGGCCTGTACTCGTCCTTCACCATTAATTCCCTGCAGAACCC ACCAGACGCCTTCAAGGCCATCAAGACGGAGAAGCTGGAGGAGCCGCCCGAAGACAGCCCCCCCGTGGAAGAAGTCAGGACTGTGATCAG GTTTGTGACCAATAAAACCGACAAGCACGTCACCAGGCCGGTGGTGTCCCTGCCTTCCACGTCAGAGGCTGCGGCGGCGTCCGCCTTCCT GGCCTCGTCCGTCTCGGCCAAGATCTCCTCTTTAATGTTGCCAAACGCTGCCAGTATTTCATCCGCCTCACCCTTCTCATCTCGGTCCCC GTCCCTGTCCCCCAACTCACCCCTCCCTTCTGAACACAGAAGCCTCTTCCTGGAGGCCGCCTGCCATGACTCCGATTCCCTGGAGCCCTT GAACCTGTCATCGGGCTCCAAGACCAAGTCTCCATCTCTTCCCCCAAAGGCCAAAAAACCCAAAGGCTTGGAAATCTCAGCGCCCCCGCT GGTGCTCTCCGGCACCGACATCGGCTCCATCGCCCTCAACAGCCCAGCCCTCCCCTCGGGATCCCTCACCCCAGCCTTCTTCACCGCACA GACACCAAATGGATTGCTTCTGACTCCGAGTCCACTGCTCTCCAGCATACATTTCTGGAGCAGCCTTAGTCCAGTTGCTCCGCTGAGTCC TGCCAGGCTGCAAGGGCCAAGCACGCTGTTCCAGTTCCCCACACTGCTTAATGGCCACATGCCAGTGCCAATCCCCAGTCTGGACAGAGC TGCTTCTCCAGTACTGCTTTCTTCAAACTCTCAGAAATCCTGATGACGTCTGGCCACAATTAAGGACTCATTAACTGATGAAACAAATTT GTCCCCACGGGCTAGTTTACCTGTGTCGTGAGAAGGACATTGTGAAACTCTTGTTAATTTGGTTTGCACTTTTCATAACATGGATAGTCT AGATTTATGTTAGCATTTTAAAAACTGTTTTTGATATATTCAAGTATATATGAAAATCTGTTTGGCATTAAGTGAATTTTAATGTTTTTG TTTTTATATCCTTTTAGCTCTTAAGTGTTGAACACTGTTGACAGTGAAGAACTTTTCTTAATGGTTTTCAGTATAACTAATAAGGATGTG AAGCTTTTTTCTCTTTAGTTCTGAGTATGCTAAACTGTGTGCTTATATAGACTATAACCAGTTGTGCCTTCCTTCGCATTTAATGTAAAT GAATGATTTATATATTTTTTAGTATTAAGAGGAAATGTTTGAAAGATGAAAATTAGTATCAAACAGCTCTCTAGTAGAATTTCATTATTT TTCACCAGTGGGCAATATGAAAGCATATATCACGTTTTGTTTTACTTTCAATTGTATAAGAATTGCCTTAGAACCTCTTTTGAACTGAAA TTCAGTAAATGTCCAAGTAATGTTTTTATAATAAACTAAGCCATATTTAGACAATAAACATTGATAAAAGAAAATGTTCTAAAGTACATT TTCAAAAGAATGGACCTTGAAAGGCTAGCCTCCTTAGCTGTTTACAGTATCTTATCTTTTAGATGCCTCCCAGACAAAAATCTGAGATGG AAAAGCTACATCAAGTTCATGCTATTCCAGGCCCAAGAATATCTCCTAGGTTAGCATATTCTTATTTCAAAAAATTAGCCCTGGTTTTCT CAGTTTTCCATAGGGAATCCCGACCATCTGATATATTTACTGTGTCAGTATAAGTAAGTTGGGGTTCCCCTGGAACTATAATTAACATTT AAAAAATCTAATGCTTTAGAAGAAGCTCACAGAGTGGTGATGAACCCAAACAACAAAGAAACCATTTTTAACACTAGGTATCTTCATCAG TATAGGTAGGTGTTCACAATTTTTGATGGATCAAAAACTTGCTGTAATACAAATAGAGAGTGGAGGTACTAAAGGCCTTGCTTGTGGAAA CTGAGAGAGGATACACTGCTTTATGTATTACTAAAGTTAGGGGAGAATGAAGGAAATCTGACAGATGAAAAATTCTACAGGAACCTCATC ATCGTGGAACTGAACTGATGATAACTTGGAACACTCCAGTAAATTCTGTTGTGTAATGTAATTTGGAGCAGTGATAATACAGACATATTT TCTGTTCCATCAGAAAATCAGCAGGCACCAGTCCAAAGGTACCACACCTGTACATGAAGAAGGAAAGTTCTAATACAAGAAAACTGAAAA GCACCAAGCTTTAAATTCAAGATTAATTACAATCCTTAACTATAAGTGATGATAAAAACTAACTTGAAATGTGACTAAATAACTGATCCA AACTGGGCATTAAGTGGCAGGATTATGAGAAAGGATAAAAAAAGAGATTTGAGAAAACACATTTCTTGAATTTTCAGAAAAAAATCTAGA CTATTGCTTTGACACTTAGAAATTCTGAGGTTTTTCAATTGGAATTGAGCATCTCTGTATGTGGGGATGTGGGCCCTTATCAAGGGATAA AAATCCAAACACTCTAACATGCCTCCTTGACTGTAAAGTAATGACACTGGTTCCAAAATTCACAAATAATAGACACTACTGTCCCCCCAC CCCCACCCCATAGGCTAAGAATAATTCTGTACCAGAATAAAAGGAGCTGGTCCAGGGAACTGATATTTACTGAACATACAAAGTTAGTGC TAGAAGGGGCCTTTGAGAATGCTTCCCGCCACCTGTTTCCAGCTCAAGACAGGTGCACAGCAGAAGCTGGGAGTTGCCTATGGCTGCACA GCTCACTGAAGGTAGAACAATGATTGGTGCTCAGTCCAATTCTGTCTCCCCCATGCCTAGCTGTTAAGTAATTACTGGTTCAAAACTACG TGTTATTAGTAAAACAAACAAAACAGATAAAGACAGCATTTAAAACTGTGTTGTCAGATAAGAGAACACATCCAAAATGCATGATTCTTA CAAACTAAAGGAAGTTAATGTGCAAAAATCTCAACCAAAACTACTATTTTTAGTATACTTGTTTACGTAAATGCTGATTGGAAATATTTA AATGACTATAGATCTGATTCTTTCTTTTCCTTTGGAAACTGGGATTAATGTATGCTCTAGATCCATTTATTAGAAATGCAAAAATACTAC AATTTTTTGATGGATGAAAATACTCCTGTAACACAAACAGAGAACTGGAGGAACTGAAGAATAACTCACTCATATAGCTCTGCCTCATTC TGTGTGTGTGTGCATGTGTGTGTTAGCAGAGGTATTTTACTCAGAAAATAGGTTTCAAAGAACATTAATGACTTTCTTTTCCCTTTTATG TCTGCTTAATCAGTGTTAAACTGCTATGGGAAAAGTTTTATAGAACTATATAACCTGAATGTTGGTCTCTTTGTACACATCTTTTCTATG >54704_54704_3_MPHOSPH9-ELK3_MPHOSPH9_chr12_123694603_ENST00000541076_ELK3_chr12_96640718_ENST00000228741_length(amino acids)=709AA_BP=370 MYTMEEFDLVKTLHKTSSSVGSDENSLHSLGLNLNTDRSSPHLSTNGVSSFSGKTRPSVIQGTVEVLTSLMQELQNSGKTDSELWKNCEH IQEEIKNLVKLQTSSASLASCEGNSSNKQVSSESQMGFFSLSSERNESVIHYPESTEPEIQQEMSTSQPDCNVDSCSVSSGYGTFCISEL NLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDGVKNENFYIQTPEECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSW AQKLKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEKSDFAAATHPRAFYLSKPDETPNAWMSDSGTGLTYWKLEEKDMHHSLPETLEKTFI SLSSTDVSPNQNIIKKVIGQKFVYKFVSFPEILKMDPHAVEISRESLLLQDSDCKASPEGREAHKHGLAALRSTSRNEYIHSGLYSSFTI NSLQNPPDAFKAIKTEKLEEPPEDSPPVEEVRTVIRFVTNKTDKHVTRPVVSLPSTSEAAAASAFLASSVSAKISSLMLPNAASISSASP FSSRSPSLSPNSPLPSEHRSLFLEAACHDSDSLEPLNLSSGSKTKSPSLPPKAKKPKGLEISAPPLVLSGTDIGSIALNSPALPSGSLTP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MPHOSPH9-ELK3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MPHOSPH9-ELK3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MPHOSPH9-ELK3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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