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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MPHOSPH9-MDM2 (FusionGDB2 ID:54707)

Fusion Gene Summary for MPHOSPH9-MDM2

check button Fusion gene summary
Fusion gene informationFusion gene name: MPHOSPH9-MDM2
Fusion gene ID: 54707
HgeneTgene
Gene symbol

MPHOSPH9

MDM2

Gene ID

10198

4193

Gene nameM-phase phosphoprotein 9MDM2 proto-oncogene
SynonymsMPP-9|MPP9ACTFS|HDMX|LSKB|hdm2
Cytomap

12q24.31

12q15

Type of geneprotein-codingprotein-coding
DescriptionM-phase phosphoprotein 9E3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hum
Modification date2020031320200329
UniProtAcc

Q99550

Q00987

Ensembl transtripts involved in fusion geneENST00000302349, ENST00000392425, 
ENST00000541076, ENST00000606320, 
ENST00000539639, 		ENST00000258148, 
ENST00000258149, ENST00000299252, 
ENST00000348801, ENST00000350057, 
ENST00000356290, ENST00000360430, 
ENST00000393410, ENST00000393412, 
ENST00000393413, ENST00000428863, 
ENST00000478070, ENST00000517852, 
ENST00000540827, ENST00000544125, 
ENST00000544561, ENST00000545204, 
ENST00000462284, 
Fusion gene scores* DoF score14 X 13 X 8=145612 X 10 X 6=720
# samples 1312
** MAII scorelog2(13/1456*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MPHOSPH9 [Title/Abstract] AND MDM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMPHOSPH9(123686711)-MDM2(69214105), # samples:1
Anticipated loss of major functional domain due to fusion event.MPHOSPH9-MDM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MPHOSPH9-MDM2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
MPHOSPH9-MDM2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

TgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

TgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

TgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

TgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

TgeneMDM2

GO:0034504

protein localization to nucleus

10360174

TgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

TgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

TgeneMDM2

GO:0045184

establishment of protein localization

10360174

TgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

TgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

TgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

TgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

TgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

TgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922


check buttonFusion gene breakpoints across MPHOSPH9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MDM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3LS-01AMPHOSPH9chr12

123686711

-MDM2chr12

69214105

+


Top

Fusion Gene ORF analysis for MPHOSPH9-MDM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000302349ENST00000258148MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000302349ENST00000258149MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000302349ENST00000299252MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000302349ENST00000348801MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000302349ENST00000350057MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000302349ENST00000356290MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000302349ENST00000360430MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000302349ENST00000393410MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000302349ENST00000393412MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000302349ENST00000393413MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000302349ENST00000428863MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000302349ENST00000478070MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000302349ENST00000517852MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000302349ENST00000540827MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000302349ENST00000544125MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000302349ENST00000544561MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000302349ENST00000545204MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000258148MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000258149MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000299252MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000348801MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000350057MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000356290MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000360430MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000393410MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000393412MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000393413MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000428863MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000478070MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000517852MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000540827MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000544125MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000544561MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000392425ENST00000545204MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000258148MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000258149MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000299252MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000348801MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000350057MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000356290MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000360430MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000393410MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000393412MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000393413MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000428863MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000478070MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000517852MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000540827MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000544125MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000544561MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000541076ENST00000545204MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000258148MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000258149MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000299252MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000348801MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000350057MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000356290MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000360430MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000393410MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000393412MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000393413MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000428863MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000478070MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000517852MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000540827MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000544125MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000544561MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
5CDS-intronENST00000606320ENST00000545204MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
Frame-shiftENST00000606320ENST00000462284MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
In-frameENST00000302349ENST00000462284MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
In-frameENST00000392425ENST00000462284MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
In-frameENST00000541076ENST00000462284MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-3CDSENST00000539639ENST00000462284MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000258148MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000258149MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000299252MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000348801MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000350057MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000356290MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000360430MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000393410MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000393412MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000393413MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000428863MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000478070MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000517852MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000540827MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000544125MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000544561MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+
intron-intronENST00000539639ENST00000545204MPHOSPH9chr12

123686711

-MDM2chr12

69214105

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000302349MPHOSPH9chr12123686711-ENST00000462284MDM2chr1269214105+835915881072773888
ENST00000541076MPHOSPH9chr12123686711-ENST00000462284MDM2chr1269214105+870019297331141013
ENST00000392425MPHOSPH9chr12123686711-ENST00000462284MDM2chr1269214105+835915881072773888

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000302349ENST00000462284MPHOSPH9chr12123686711-MDM2chr1269214105+0.0002293010.9997707
ENST00000541076ENST00000462284MPHOSPH9chr12123686711-MDM2chr1269214105+5.30E-050.99994695
ENST00000392425ENST00000462284MPHOSPH9chr12123686711-MDM2chr1269214105+0.0002293010.9997707

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Fusion Genomic Features for MPHOSPH9-MDM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for MPHOSPH9-MDM2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:123686711/chr12:69214105)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPHOSPH9

Q99550

MDM2

Q00987

FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:30879903}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMDM2chr12:123686711chr12:69214105ENST0000025814939210_21596437.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:123686711chr12:69214105ENST0000025814939243_30196437.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:123686711chr12:69214105ENST0000029925205210_2150322.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:123686711chr12:69214105ENST0000029925205243_3010322.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:123686711chr12:69214105ENST0000034880103210_2150266.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:123686711chr12:69214105ENST0000034880103243_3010266.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:123686711chr12:69214105ENST0000035629006210_2150322.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:123686711chr12:69214105ENST0000035629006243_3010322.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:123686711chr12:69214105ENST0000036043004210_2150297.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:123686711chr12:69214105ENST0000036043004243_3010297.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341203210_2150219.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341203243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341302210_2150219.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341302243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:123686711chr12:69214105ENST0000042886304210_2150271.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:123686711chr12:69214105ENST0000042886304243_3010271.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:123686711chr12:69214105ENST00000462284311210_215102498.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:123686711chr12:69214105ENST00000462284311243_301102498.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:123686711chr12:69214105ENST0000054082705210_2150297.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:123686711chr12:69214105ENST0000054082705243_3010297.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:123686711chr12:69214105ENST000002992520526_1090322.0DomainSWIB/MDM2
TgeneMDM2chr12:123686711chr12:69214105ENST000003488010326_1090266.0DomainSWIB/MDM2
TgeneMDM2chr12:123686711chr12:69214105ENST000003562900626_1090322.0DomainSWIB/MDM2
TgeneMDM2chr12:123686711chr12:69214105ENST000003604300426_1090297.0DomainSWIB/MDM2
TgeneMDM2chr12:123686711chr12:69214105ENST000003934120326_1090219.0DomainSWIB/MDM2
TgeneMDM2chr12:123686711chr12:69214105ENST000003934130226_1090219.0DomainSWIB/MDM2
TgeneMDM2chr12:123686711chr12:69214105ENST000004288630426_1090271.0DomainSWIB/MDM2
TgeneMDM2chr12:123686711chr12:69214105ENST000005408270526_1090297.0DomainSWIB/MDM2
TgeneMDM2chr12:123686711chr12:69214105ENST0000025814939179_18596437.0MotifNuclear localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000025814939190_20296437.0MotifNote=Nuclear export signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000025814939466_47396437.0MotifNucleolar localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000029925205179_1850322.0MotifNuclear localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000029925205190_2020322.0MotifNote=Nuclear export signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000029925205466_4730322.0MotifNucleolar localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000034880103179_1850266.0MotifNuclear localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000034880103190_2020266.0MotifNote=Nuclear export signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000034880103466_4730266.0MotifNucleolar localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000035629006179_1850322.0MotifNuclear localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000035629006190_2020322.0MotifNote=Nuclear export signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000035629006466_4730322.0MotifNucleolar localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000036043004179_1850297.0MotifNuclear localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000036043004190_2020297.0MotifNote=Nuclear export signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000036043004466_4730297.0MotifNucleolar localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341203179_1850219.0MotifNuclear localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341203190_2020219.0MotifNote=Nuclear export signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341203466_4730219.0MotifNucleolar localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341302179_1850219.0MotifNuclear localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341302190_2020219.0MotifNote=Nuclear export signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341302466_4730219.0MotifNucleolar localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000042886304179_1850271.0MotifNuclear localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000042886304190_2020271.0MotifNote=Nuclear export signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000042886304466_4730271.0MotifNucleolar localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST00000462284311179_185102498.0MotifNuclear localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST00000462284311190_202102498.0MotifNote=Nuclear export signal
TgeneMDM2chr12:123686711chr12:69214105ENST00000462284311466_473102498.0MotifNucleolar localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000054082705179_1850297.0MotifNuclear localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000054082705190_2020297.0MotifNote=Nuclear export signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000054082705466_4730297.0MotifNucleolar localization signal
TgeneMDM2chr12:123686711chr12:69214105ENST0000025814939210_30496437.0RegionNote=ARF-binding
TgeneMDM2chr12:123686711chr12:69214105ENST0000025814939242_33196437.0RegionNote=Region II
TgeneMDM2chr12:123686711chr12:69214105ENST00000299252051_1010322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:123686711chr12:69214105ENST0000029925205210_3040322.0RegionNote=ARF-binding
TgeneMDM2chr12:123686711chr12:69214105ENST0000029925205242_3310322.0RegionNote=Region II
TgeneMDM2chr12:123686711chr12:69214105ENST00000348801031_1010266.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:123686711chr12:69214105ENST0000034880103210_3040266.0RegionNote=ARF-binding
TgeneMDM2chr12:123686711chr12:69214105ENST0000034880103242_3310266.0RegionNote=Region II
TgeneMDM2chr12:123686711chr12:69214105ENST00000356290061_1010322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:123686711chr12:69214105ENST0000035629006210_3040322.0RegionNote=ARF-binding
TgeneMDM2chr12:123686711chr12:69214105ENST0000035629006242_3310322.0RegionNote=Region II
TgeneMDM2chr12:123686711chr12:69214105ENST00000360430041_1010297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:123686711chr12:69214105ENST0000036043004210_3040297.0RegionNote=ARF-binding
TgeneMDM2chr12:123686711chr12:69214105ENST0000036043004242_3310297.0RegionNote=Region II
TgeneMDM2chr12:123686711chr12:69214105ENST00000393412031_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341203210_3040219.0RegionNote=ARF-binding
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341203242_3310219.0RegionNote=Region II
TgeneMDM2chr12:123686711chr12:69214105ENST00000393413021_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341302210_3040219.0RegionNote=ARF-binding
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341302242_3310219.0RegionNote=Region II
TgeneMDM2chr12:123686711chr12:69214105ENST00000428863041_1010271.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:123686711chr12:69214105ENST0000042886304210_3040271.0RegionNote=ARF-binding
TgeneMDM2chr12:123686711chr12:69214105ENST0000042886304242_3310271.0RegionNote=Region II
TgeneMDM2chr12:123686711chr12:69214105ENST00000462284311210_304102498.0RegionNote=ARF-binding
TgeneMDM2chr12:123686711chr12:69214105ENST00000462284311242_331102498.0RegionNote=Region II
TgeneMDM2chr12:123686711chr12:69214105ENST00000540827051_1010297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:123686711chr12:69214105ENST0000054082705210_3040297.0RegionNote=ARF-binding
TgeneMDM2chr12:123686711chr12:69214105ENST0000054082705242_3310297.0RegionNote=Region II
TgeneMDM2chr12:123686711chr12:69214105ENST0000025814939299_32896437.0Zinc fingerRanBP2-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000025814939438_47996437.0Zinc fingerRING-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000029925205299_3280322.0Zinc fingerRanBP2-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000029925205438_4790322.0Zinc fingerRING-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000034880103299_3280266.0Zinc fingerRanBP2-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000034880103438_4790266.0Zinc fingerRING-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000035629006299_3280322.0Zinc fingerRanBP2-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000035629006438_4790322.0Zinc fingerRING-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000036043004299_3280297.0Zinc fingerRanBP2-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000036043004438_4790297.0Zinc fingerRING-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341203299_3280219.0Zinc fingerRanBP2-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341203438_4790219.0Zinc fingerRING-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341302299_3280219.0Zinc fingerRanBP2-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341302438_4790219.0Zinc fingerRING-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000042886304299_3280271.0Zinc fingerRanBP2-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000042886304438_4790271.0Zinc fingerRING-type
TgeneMDM2chr12:123686711chr12:69214105ENST00000462284311299_328102498.0Zinc fingerRanBP2-type
TgeneMDM2chr12:123686711chr12:69214105ENST00000462284311438_479102498.0Zinc fingerRING-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000054082705299_3280297.0Zinc fingerRanBP2-type
TgeneMDM2chr12:123686711chr12:69214105ENST0000054082705438_4790297.0Zinc fingerRING-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMPHOSPH9chr12:123686711chr12:69214105ENST00000302349-7201109_11744931029.0Coiled coilOntology_term=ECO:0000255
HgeneMPHOSPH9chr12:123686711chr12:69214105ENST00000302349-720609_8044931029.0Coiled coilOntology_term=ECO:0000255
HgeneMPHOSPH9chr12:123686711chr12:69214105ENST00000392425-7201109_11744931032.0Coiled coilOntology_term=ECO:0000255
HgeneMPHOSPH9chr12:123686711chr12:69214105ENST00000392425-720609_8044931032.0Coiled coilOntology_term=ECO:0000255
TgeneMDM2chr12:123686711chr12:69214105ENST000002581493926_10996437.0DomainSWIB/MDM2
TgeneMDM2chr12:123686711chr12:69214105ENST0000046228431126_109102498.0DomainSWIB/MDM2
TgeneMDM2chr12:123686711chr12:69214105ENST00000258149391_10196437.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:123686711chr12:69214105ENST000004622843111_101102498.0RegionSufficient to promote the mitochondrial pathway of apoptosis


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Fusion Gene Sequence for MPHOSPH9-MDM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54707_54707_1_MPHOSPH9-MDM2_MPHOSPH9_chr12_123686711_ENST00000302349_MDM2_chr12_69214105_ENST00000462284_length(transcript)=8359nt_BP=1588nt
ATATACAGGAGGAGATAAAAAATTTAGTCAAATTACAGACTAGTAGTGCTTCCTTAGCTTCCTGTGAAGGAAATTCTTCAAACAAACAAG
TATCTTCGGAAAGTCAAATGGGTTTTTTTTCTCTAAGCAGTGAGAGAAATGAATCTGTTATCCATTATCCTGAATCCACAGAACCTGAAA
TACAGCAAGAAATGTCCACGTCACAACCAGACTGCAATGTGGATAGTTGCTCAGTAAGCAGTGGATATGGCACCTTTTGTATCTCAGAAT
TAAATCTGTACAAATCTAAAGACCCTAAGGAGTTCATGGAGCACATAGATGTTCCCAAAGGACAGTATGTAGCACCTGCGGTGCCGGCTG
AGTCACTTGTAGATGGTGTGAAAAATGAGAATTTTTATATACAGACTCCTGAAGAGTGTCATGTGTCTTTAAAGGAAGATGTATCCATTT
CTCCTGGTGAATTTGAACATAATTTTCTTGGTGAAAATAAGGTTTCTGAAGTATACAGTGGGAAAACAAATAGTAATGCTATAACATCAT
GGGCACAAAAACTGAAGCAGAACCAACCAAAGAGAGCACATGTAGAAGATGGAGGTTCAAGATCTAAACAAGGAAATGAGCAAAGTAAGA
AGACACCAATTGAGAAATCTGATTTTGCTGCTGCTACACATCCTCGTGCTTTTTACCTCAGTAAACCAGATGAAACTCCAAATGCTTGGA
TGTCTGATTCAGGAACAGGATTGACTTACTGGAAACTAGAGGAAAAGGATATGCACCACTCTTTGCCTGAAACTTTAGAGAAGACGTTCA
TATCATTGTCTTCCACAGATGTGTCACCAAACCAGTCTAATACTAGTAATGAGATGAAGCTACCGTCACTGAAGGATATTTATTATAAAA
AACAAAGGGAAAACAAGCAGTTACCTGAGAGGAATCTCACTTCTGCTTCCAACCCAAATCATCCACCAGAGGTCCTGACTCTAGATCCTA
CGTTACACATGAAGCCAAAGCAGCAGATTTCAGGGATTCAACCTCACGGCCTTCCGAATGCCCTTGATGACAGAATATCCTTTTCCCCGG
ACTCTGTTCTAGAGCCTAGTATGTCTAGTCCCTCTGACATAGACTCATTTTCACAAGCAAGTAATGTCACTTCTCAGTTACCTGGATTTC
CAAAATATCCCTCACACACAAAAGCTTCTCCGGTGGACTCTTGGAAAAATCAGACATTCCAAAACGAAAGTAGGACCAGTTCCACGTTTC
CGTCAGTATATACCATTACTAGTAATGATATCTCGGTCAACACTGTAGATGAAGAAAACACTGTCATGGTTGCTTCGGCCTCAGTCAGTC
AGTCCCAGCTTCCAGGTACAGCCAACAGTGTCCCAGAATGCATTTCATTGACTTCCTTGGAAGATCCTGTGATATTGTCTAAGATTAGGC
AGAATCTGAAGGAAAAGCATGCTCGACACATAGCAGATCTTCGAGCTTATTATGAATCAGAAATAAATAGTTTGAAACAGAAGCTGGAGG
CAAAAGAAATCTCTGGAGTTGAAGATTGGAAGATAACCAATCAAATTCTTGTAGACAGGAAAATATATACCATGATCTACAGGAACTTGG
TAGTAGTCAATCAGCAGGAATCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACC
TTGTACAAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGA
CAGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGG
CTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATCTTGATGCTGGTG
TAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAG
ATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATA
CAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGACTATTGGAAATGCACTTCATGCAATGAAATGAATCCCCCCCTTCCATCAC
ATTGCAACAGATGTTGGGCCCTTCGTGAGAATTGGCTTCCTGAAGATAAAGGGAAAGATAAAGGGGAAATCTCTGAGAAAGCCAAACTGG
AAAACTCAACACAAGCTGAAGAGGGCTTTGATGTTCCTGATTGTAAAAAAACTATAGTGAATGATTCCAGAGAGTCATGTGTTGAGGAAA
ATGATGATAAAATTACACAAGCTTCACAATCACAAGAAAGTGAAGACTATTCTCAGCCATCAACTTCTAGTAGCATTATTTATAGCAGCC
AAGAAGATGTGAAAGAGTTTGAAAGGGAAGAAACCCAAGACAAAGAAGAGAGTGTGGAATCTAGTTTGCCCCTTAATGCCATTGAACCTT
GTGTGATTTGTCAAGGTCGACCTAAAAATGGTTGCATTGTCCATGGCAAAACAGGACATCTTATGGCCTGCTTTACATGTGCAAAGAAGC
TAAAGAAAAGGAATAAGCCCTGCCCAGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGTTGACCTGTCTATAAG
AGAATTATATATTTCTAACTATATAACCCTAGGAATTTAGACAACCTGAAATTTATTCACATATATCAAAGTGAGAAAATGCCTCAATTC
ACATAGATTTCTTCTCTTTAGTATAATTGACCTACTTTGGTAGTGGAATAGTGAATACTTACTATAATTTGACTTGAATATGTAGCTCAT
CCTTTACACCAACTCCTAATTTTAAATAATTTCTACTCTGTCTTAAATGAGAAGTACTTGGTTTTTTTTTTTCTTAAATATGTATATGAC
ATTTAAATGTAACTTATTATTTTTTTTGAGACCGAGTCTTGCTCTGTTACCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAA
GCTCTGCCTCCCGGGTTCGCACCATTCTCCTGCCTCAGCCTCCCAATTAGCTTGGCCTACAGTCATCTGCCACCACACCTGGCTAATTTT
TTGTACTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAA
AGTGCTGGGATTACAGGCATGAGCCACCGCGTCCGGCCTAAATGTCACTTAGTACCTTTGATATAAAGAGAAAATGTGTGAAAGATTTAG
TTTTTTGTTTTTTTGTTTGTTTGTTTGTTTGTTTGTTTTGAGATGAGTCTCTCTGTCGCCCAGGCTGGAGTGCAGTGTCATGATCTAGCA
GTCTCCGCTTCCCGGGTTCAAGCCATTCTCCTGGCTCAGCCTCTGGAGCAGCTGGGATTACAGGCATGCACCACCATGCCCAGCTAATTT
TTGTATTTTTAGTAGAGATAGGGTTTCACCATGTTGGCCAGGCTGGTCACGAACTCCTGACCTCAAGTGAGGTCACCCGCCTCGGCCTCC
CGAAGTGCTGGGATTGCAGATGTGAGCCACCATGTCCAGCCAAGAATTAGTATTTAAATTTTAGATACTCTTTTTTTTTTTTTTTTTTTT
TTTTTTTGAGACAGAGTCTTGCTCCATCACCCATGCTAGAGTGCAGTGGAGTGATCTCGGCTCACTGCAACTTCCGCCTTCTGGGTTCAA
GCTATTCTCCTGCCTCAGCCTTCCAAGTAACTGGGATTACAGGCATGTACCACCATACCAGCTGATTTTTTTGTATTTTTAGTAAAGACA
GGGTTTCACCATGTTAGCCAGGCTGATCTTGAACTCCTAAACTCAAGTGATCTACTCACCTCAGCCTCCCAAAATGCTGGGATTACAGAT
GTGAGGCACCTGGCCTCAGATTTTTGATACTCTTAAACCTTCTGATCCTTAGTTTCTCTCTCCAAAATACTCTTTCTAGGTTAAAAAAAA
AAAGGCTCTTATATTTGGTGCTATGTAAATGAAAATGTTTTTTAGGTTTTCTTGATTTAACAATAGAGACAGGGTCTCCCTGTGTTGCCC
AGGCTGGTCTCGAACTCCTGGGCTCAAGAGATCCTCCTGTCTTGGCCTCGCAAAGTGCTAAGTAGGATTACAGGCGTTAGCCACCACACC
CGGCTGTAAAAATGTACTTATTCTCCAGCCTCTTTTGTATAAACCATAGTAAGGGATGGGAGTAATGATGTTATCTGTGAAAATAGCCAC
CATTTACCCGTAAGACAAAACTTGTTAAAGCCTCCTGAGTCTAACCTAGATTACATCAGGCCCTTTTTCACACACAAAAAAATCCTTTAT
GGGATTTAATGGAATCTGTTGTTTCCCCCTAAGTTGAAAAACAACTCTAAGACACTTTAAAGTACCTTCTTGGCCTGGGTTACATGGTTC
CCAGCCTAGGTTTCAGACTTTTGCTTAAGGCCAGTTTTAGAAACCCGTGAATTCAGAAAAGTTAATTCAGAAATTTGATAAACAGAATTG
TTATTTAAAAACTAACTGGAAAGATTGTTAAGTTCTTTCTGAATTATTCAGAAATTATGCATCATTTTCCTTCAAGAATGACAGGGTCAG
CATGTGGAATTCCAAGATACCTCTTGACTTCCTCTCAAGCTCCGTGTTTGGTCAGTGGAGGCCCATCCGAGCTCAGCACTGAGAAGTGTT
AGTTTCTTTGGGACCCATCTACCCTGACCACATCATGATGTTCATCTGCAGCTGTTGCAAGGTGTTCAGATTGTATAAACATAAATGTCA
CAAAAACTTTAAAAGAAGTGCAATTCTCAAAAGGTTAGGTGGACTAAAGCATTCTGTAAAGCAACTGCTAATAATGAGCTTACAGTGGAT
TTGAATTTGAAAAATATAGTAACAAGCCTGTCAAATATCTGCAAGAACTATGGAATAAAACTACTGATGCAGTGAAGACAGTTGAAAAGA
TCAAACAAATGCCAAGCTATATTTATAATGAACAAATTCAAGAAAAAGGACTACGGAAAGTTCAGGACATCAAAGAAGTCAGGCAAAACT
CATCTTGACCCCTGTTGCAGGCAAAGGAACGCAGCTGGAAGAAAAGATGATATAACAGTTAACAGGATGCAGACATGGCAGAGGTTTCCT
AAAAATCTCATTATCTATAACCATTTCTATATTTACATTTGAAAATCTCCTTTGGAGACTTAGAACCTCTAAATTATTGACTTATTTTTT
ATATAAGGTCACTCCGATGAAAGGTGATTACAAAATCATCTACATTGCTGTCTACAAAACAGATAATATGGATGTTTGATCGCATCTCAT
TGTTAACTCTTTACTGATATGTTTGTAAATACAGAAGTGAAATGTGGACATAAAATAGTTACGCTATTTGGTTAATGGTACTAGACAACA
TGTAATTAATGACATTCAAAAATTTATGGCTAGTGATATATATAAAGTAAAATTTTCTTTGCAGTAAAATATGCCCTTTATTATAGAAGG
GAGGATATAAGGAACCAACAGTTTGTATGAAAATAGCTCAAATAATATCTTTTATTTTGATTTTAATATTTCTTATTTTGGTTTATTAGT
GTCTTAGAACAAAATGGCCTTATATAATGAAGCCTAGTTATGCTGGACTGTTTTGATCTCTTTTAATTGTTCTGACAGATAGTTGGGGAT
GAGAGCCGAATAAGGTTTGCCTGAAATAACTGACACTATATAATTTCTGCTTTGGCAAATACTAAGTTCTAACTTGTCATTCCTGGTAGA
ACAAGCTTTATTTTTCGAGCCTAGCAATGATCTAGAAGCAGATGTTATCTCAGTGCCTTTTGCAATTTGTTGTGTGGGTTTTTTTTTTTT
TAAAGCCACACAATAATTTTGGAAAACAATGTATGGGTAGAACATGTGTCTGTTAATTGCACACAAAACCACTTTTAATGGGTACAGAGT
TAAATTTGAAGGAATAAGTTCTAGCTGAAGTATTATGAACTCCAAATAATGCTTTGAGGACCTCCAAAGGTAAAAGTACTAATCCCTTTG
GCCATTTATTGAGAGAGAGAGAGAGAGAGAGTAGGGTGACTATAGTTAATGTATTGAATGTTCTTGCTACAAATAAATGATATTTGAGCT
GATGGGTGTGCTAATTACACTGATTTGATCAATACCCATTGTATGTGAAACAGTACATACACCATATTTACAATTATGTATTTAACATTT
AAAATTTCTAATATAAGTATCTCTCAAACTGTGGATTAACTTCTTGATTTATATTTAAATATGAATCTTAAGCAAAACAGTGAAAATAAC
CATCTTGATTTAGTGTTTTTCTCCCATATGTGAATTGTATATACTTAGGTGAAGACAATAAAATCAACTGAACTGTAAGCTTAGAATAGG
ACTGAGGTAATTCTGCACAGCAACTTTACTAATGGTACATTGTTGCTTCAAAACTCTCTCTCTCTCTCTCTGTCTGTCTCAATAAATGGC
CAAAGGGATTAGTAGTTTACCTGTGGAGGTCCTCCAAGCATTATTTGGAGTTGATAATACTTCAGCTACAACCAAGCAGAATCTCTTTTT
TTTGGAGGTCCTCGAAGCATTATTTGGAGTTGATAATACTTCAGCTTCAATTTGGAGTTGATAATATTTCAGCTAGAACCTAGTAGAATC
TGTTTTTTTCCTTTGGAGGTCCTCAAAGCATTATTGGAGTTCATAATACTGAAGCTAGAACCAAGCAGAATCTGTTTTTTTCTGAGGAGT
ATCGGTAGCATAAATGTGATTATAAACATAGTACACTTGATATATGGAGGCAGTGACAGCTATTTTTACAAAATTTAAATCTGCAAATGG
ATTCAACATGTTTATGGGTTATTAAAATTGTCTGATTTCTTAGGTTCTTTATAGTACACGTGTTGAAAATAAATGATTAAGAATTGTTTC
AAGAATGCAATTATTTGATCTTAAATTTTTATGAGTTGTTAAAATAGAAATTATTTGAATATCATATATTTGGGTAACAAAAGGCACAAG
TCTGAATGTGTTTCTTTTTCTGGAATGGCCATGCCTGCCCACTTTAGAAATACAAATATCACTGGGCAGCTTGAAGCAGTTGGGAGCCTC
CAATGAGAGCAACTTGAGAGAATGATGTTGCAAGTTAGTAGGAGTAAGAAATGCTGTGTTCTCCCTGTCTTCTCTTAGGTCACATGGCAG
CCTGGCCTAAGTGATCGTGAATGGTCTATAAGGGAGGTAGCTGGGACAGGGAGGGGAGTTTGGGCTAGCCACCGTACCACTTGTCAGCGT
GAAAAGTAAGATTGTAATTGCCTGTTTAGTTTTCTGCCTCATCTTTGAAAGTTCCACCAAGCTGGGAACCTCTTGATTGTGAGGCACAAA
TGTAAGTACATCAGAAAAAAACAAAAAAACTGGCTTTAAAGCAGGAGCTTGTGGGCCCCTAAGCCAGACGGGGACTAGCTTTTGGCATTA
TATAATTAAGATTTTTTAAATCCTTAATAAGGGTTTTATTTTATTTTTATTTATTTTTTGAGACGGAGTCTTGCTCTGTGGCTCAGGCTG
GAGTACAGTGGTGCAATCTTGGCTCACTGCAACCTCTGCCTCCTGGCTGTGTTCAAGTGGTTCTGCTTCAGCCTCCCAAGTAGCTGGGGT
TAGAGCACCCTGTCACCACGCCCCGCTAATTTTTGTATTTCTAGCAGAGATGAAGTTTCACTATGTTGGCCAGGCTGGGCTCAAACTCCT
GACCTCAAGTGATCTGCCCGCCTTGGCCCCCCAAAGTGCTGTGATTACAGGCGTGAGCCGCCACGCCCAGCCTAATAAGGGTTTTAAAGA
TAATTAGTGTGTAGGTCTGTAGGCTTATGATGGTAACCACAAGTTGTTAATGGCATTGTGAAAAGTTTTTAGTTGCGCTTTATGGGTGGA
TGCTGAATTACATTTTGATTTGATACTTATAAAAAGAAAAAGTATTTCTTCAGCTTAAAAAATTGTTTAAAAGTTTGTGATCATATTGTC
TACCATGTAGCCAGCTTTCAATTATATGTAAGAGGGACTTTTTGACATTTACAAATAATACTTTGAGGTAGATATCTGAAAGCACCAGCA

>54707_54707_1_MPHOSPH9-MDM2_MPHOSPH9_chr12_123686711_ENST00000302349_MDM2_chr12_69214105_ENST00000462284_length(amino acids)=888AA_BP=493
MGFFSLSSERNESVIHYPESTEPEIQQEMSTSQPDCNVDSCSVSSGYGTFCISELNLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDG
VKNENFYIQTPEECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSWAQKLKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEK
SDFAAATHPRAFYLSKPDETPNAWMSDSGTGLTYWKLEEKDMHHSLPETLEKTFISLSSTDVSPNQSNTSNEMKLPSLKDIYYKKQRENK
QLPERNLTSASNPNHPPEVLTLDPTLHMKPKQQISGIQPHGLPNALDDRISFSPDSVLEPSMSSPSDIDSFSQASNVTSQLPGFPKYPSH
TKASPVDSWKNQTFQNESRTSSTFPSVYTITSNDISVNTVDEENTVMVASASVSQSQLPGTANSVPECISLTSLEDPVILSKIRQNLKEK
HARHIADLRAYYESEINSLKQKLEAKEISGVEDWKITNQILVDRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQ
EEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSG
DWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCW
ALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKE

--------------------------------------------------------------
>54707_54707_2_MPHOSPH9-MDM2_MPHOSPH9_chr12_123686711_ENST00000392425_MDM2_chr12_69214105_ENST00000462284_length(transcript)=8359nt_BP=1588nt
ATATACAGGAGGAGATAAAAAATTTAGTCAAATTACAGACTAGTAGTGCTTCCTTAGCTTCCTGTGAAGGAAATTCTTCAAACAAACAAG
TATCTTCGGAAAGTCAAATGGGTTTTTTTTCTCTAAGCAGTGAGAGAAATGAATCTGTTATCCATTATCCTGAATCCACAGAACCTGAAA
TACAGCAAGAAATGTCCACGTCACAACCAGACTGCAATGTGGATAGTTGCTCAGTAAGCAGTGGATATGGCACCTTTTGTATCTCAGAAT
TAAATCTGTACAAATCTAAAGACCCTAAGGAGTTCATGGAGCACATAGATGTTCCCAAAGGACAGTATGTAGCACCTGCGGTGCCGGCTG
AGTCACTTGTAGATGGTGTGAAAAATGAGAATTTTTATATACAGACTCCTGAAGAGTGTCATGTGTCTTTAAAGGAAGATGTATCCATTT
CTCCTGGTGAATTTGAACATAATTTTCTTGGTGAAAATAAGGTTTCTGAAGTATACAGTGGGAAAACAAATAGTAATGCTATAACATCAT
GGGCACAAAAACTGAAGCAGAACCAACCAAAGAGAGCACATGTAGAAGATGGAGGTTCAAGATCTAAACAAGGAAATGAGCAAAGTAAGA
AGACACCAATTGAGAAATCTGATTTTGCTGCTGCTACACATCCTCGTGCTTTTTACCTCAGTAAACCAGATGAAACTCCAAATGCTTGGA
TGTCTGATTCAGGAACAGGATTGACTTACTGGAAACTAGAGGAAAAGGATATGCACCACTCTTTGCCTGAAACTTTAGAGAAGACGTTCA
TATCATTGTCTTCCACAGATGTGTCACCAAACCAGTCTAATACTAGTAATGAGATGAAGCTACCGTCACTGAAGGATATTTATTATAAAA
AACAAAGGGAAAACAAGCAGTTACCTGAGAGGAATCTCACTTCTGCTTCCAACCCAAATCATCCACCAGAGGTCCTGACTCTAGATCCTA
CGTTACACATGAAGCCAAAGCAGCAGATTTCAGGGATTCAACCTCACGGCCTTCCGAATGCCCTTGATGACAGAATATCCTTTTCCCCGG
ACTCTGTTCTAGAGCCTAGTATGTCTAGTCCCTCTGACATAGACTCATTTTCACAAGCAAGTAATGTCACTTCTCAGTTACCTGGATTTC
CAAAATATCCCTCACACACAAAAGCTTCTCCGGTGGACTCTTGGAAAAATCAGACATTCCAAAACGAAAGTAGGACCAGTTCCACGTTTC
CGTCAGTATATACCATTACTAGTAATGATATCTCGGTCAACACTGTAGATGAAGAAAACACTGTCATGGTTGCTTCGGCCTCAGTCAGTC
AGTCCCAGCTTCCAGGTACAGCCAACAGTGTCCCAGAATGCATTTCATTGACTTCCTTGGAAGATCCTGTGATATTGTCTAAGATTAGGC
AGAATCTGAAGGAAAAGCATGCTCGACACATAGCAGATCTTCGAGCTTATTATGAATCAGAAATAAATAGTTTGAAACAGAAGCTGGAGG
CAAAAGAAATCTCTGGAGTTGAAGATTGGAAGATAACCAATCAAATTCTTGTAGACAGGAAAATATATACCATGATCTACAGGAACTTGG
TAGTAGTCAATCAGCAGGAATCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACC
TTGTACAAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGA
CAGAAGAAAATTCAGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGG
CTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATCTTGATGCTGGTG
TAAGTGAACATTCAGGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAG
ATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATA
CAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGACTATTGGAAATGCACTTCATGCAATGAAATGAATCCCCCCCTTCCATCAC
ATTGCAACAGATGTTGGGCCCTTCGTGAGAATTGGCTTCCTGAAGATAAAGGGAAAGATAAAGGGGAAATCTCTGAGAAAGCCAAACTGG
AAAACTCAACACAAGCTGAAGAGGGCTTTGATGTTCCTGATTGTAAAAAAACTATAGTGAATGATTCCAGAGAGTCATGTGTTGAGGAAA
ATGATGATAAAATTACACAAGCTTCACAATCACAAGAAAGTGAAGACTATTCTCAGCCATCAACTTCTAGTAGCATTATTTATAGCAGCC
AAGAAGATGTGAAAGAGTTTGAAAGGGAAGAAACCCAAGACAAAGAAGAGAGTGTGGAATCTAGTTTGCCCCTTAATGCCATTGAACCTT
GTGTGATTTGTCAAGGTCGACCTAAAAATGGTTGCATTGTCCATGGCAAAACAGGACATCTTATGGCCTGCTTTACATGTGCAAAGAAGC
TAAAGAAAAGGAATAAGCCCTGCCCAGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGTTGACCTGTCTATAAG
AGAATTATATATTTCTAACTATATAACCCTAGGAATTTAGACAACCTGAAATTTATTCACATATATCAAAGTGAGAAAATGCCTCAATTC
ACATAGATTTCTTCTCTTTAGTATAATTGACCTACTTTGGTAGTGGAATAGTGAATACTTACTATAATTTGACTTGAATATGTAGCTCAT
CCTTTACACCAACTCCTAATTTTAAATAATTTCTACTCTGTCTTAAATGAGAAGTACTTGGTTTTTTTTTTTCTTAAATATGTATATGAC
ATTTAAATGTAACTTATTATTTTTTTTGAGACCGAGTCTTGCTCTGTTACCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAA
GCTCTGCCTCCCGGGTTCGCACCATTCTCCTGCCTCAGCCTCCCAATTAGCTTGGCCTACAGTCATCTGCCACCACACCTGGCTAATTTT
TTGTACTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAA
AGTGCTGGGATTACAGGCATGAGCCACCGCGTCCGGCCTAAATGTCACTTAGTACCTTTGATATAAAGAGAAAATGTGTGAAAGATTTAG
TTTTTTGTTTTTTTGTTTGTTTGTTTGTTTGTTTGTTTTGAGATGAGTCTCTCTGTCGCCCAGGCTGGAGTGCAGTGTCATGATCTAGCA
GTCTCCGCTTCCCGGGTTCAAGCCATTCTCCTGGCTCAGCCTCTGGAGCAGCTGGGATTACAGGCATGCACCACCATGCCCAGCTAATTT
TTGTATTTTTAGTAGAGATAGGGTTTCACCATGTTGGCCAGGCTGGTCACGAACTCCTGACCTCAAGTGAGGTCACCCGCCTCGGCCTCC
CGAAGTGCTGGGATTGCAGATGTGAGCCACCATGTCCAGCCAAGAATTAGTATTTAAATTTTAGATACTCTTTTTTTTTTTTTTTTTTTT
TTTTTTTGAGACAGAGTCTTGCTCCATCACCCATGCTAGAGTGCAGTGGAGTGATCTCGGCTCACTGCAACTTCCGCCTTCTGGGTTCAA
GCTATTCTCCTGCCTCAGCCTTCCAAGTAACTGGGATTACAGGCATGTACCACCATACCAGCTGATTTTTTTGTATTTTTAGTAAAGACA
GGGTTTCACCATGTTAGCCAGGCTGATCTTGAACTCCTAAACTCAAGTGATCTACTCACCTCAGCCTCCCAAAATGCTGGGATTACAGAT
GTGAGGCACCTGGCCTCAGATTTTTGATACTCTTAAACCTTCTGATCCTTAGTTTCTCTCTCCAAAATACTCTTTCTAGGTTAAAAAAAA
AAAGGCTCTTATATTTGGTGCTATGTAAATGAAAATGTTTTTTAGGTTTTCTTGATTTAACAATAGAGACAGGGTCTCCCTGTGTTGCCC
AGGCTGGTCTCGAACTCCTGGGCTCAAGAGATCCTCCTGTCTTGGCCTCGCAAAGTGCTAAGTAGGATTACAGGCGTTAGCCACCACACC
CGGCTGTAAAAATGTACTTATTCTCCAGCCTCTTTTGTATAAACCATAGTAAGGGATGGGAGTAATGATGTTATCTGTGAAAATAGCCAC
CATTTACCCGTAAGACAAAACTTGTTAAAGCCTCCTGAGTCTAACCTAGATTACATCAGGCCCTTTTTCACACACAAAAAAATCCTTTAT
GGGATTTAATGGAATCTGTTGTTTCCCCCTAAGTTGAAAAACAACTCTAAGACACTTTAAAGTACCTTCTTGGCCTGGGTTACATGGTTC
CCAGCCTAGGTTTCAGACTTTTGCTTAAGGCCAGTTTTAGAAACCCGTGAATTCAGAAAAGTTAATTCAGAAATTTGATAAACAGAATTG
TTATTTAAAAACTAACTGGAAAGATTGTTAAGTTCTTTCTGAATTATTCAGAAATTATGCATCATTTTCCTTCAAGAATGACAGGGTCAG
CATGTGGAATTCCAAGATACCTCTTGACTTCCTCTCAAGCTCCGTGTTTGGTCAGTGGAGGCCCATCCGAGCTCAGCACTGAGAAGTGTT
AGTTTCTTTGGGACCCATCTACCCTGACCACATCATGATGTTCATCTGCAGCTGTTGCAAGGTGTTCAGATTGTATAAACATAAATGTCA
CAAAAACTTTAAAAGAAGTGCAATTCTCAAAAGGTTAGGTGGACTAAAGCATTCTGTAAAGCAACTGCTAATAATGAGCTTACAGTGGAT
TTGAATTTGAAAAATATAGTAACAAGCCTGTCAAATATCTGCAAGAACTATGGAATAAAACTACTGATGCAGTGAAGACAGTTGAAAAGA
TCAAACAAATGCCAAGCTATATTTATAATGAACAAATTCAAGAAAAAGGACTACGGAAAGTTCAGGACATCAAAGAAGTCAGGCAAAACT
CATCTTGACCCCTGTTGCAGGCAAAGGAACGCAGCTGGAAGAAAAGATGATATAACAGTTAACAGGATGCAGACATGGCAGAGGTTTCCT
AAAAATCTCATTATCTATAACCATTTCTATATTTACATTTGAAAATCTCCTTTGGAGACTTAGAACCTCTAAATTATTGACTTATTTTTT
ATATAAGGTCACTCCGATGAAAGGTGATTACAAAATCATCTACATTGCTGTCTACAAAACAGATAATATGGATGTTTGATCGCATCTCAT
TGTTAACTCTTTACTGATATGTTTGTAAATACAGAAGTGAAATGTGGACATAAAATAGTTACGCTATTTGGTTAATGGTACTAGACAACA
TGTAATTAATGACATTCAAAAATTTATGGCTAGTGATATATATAAAGTAAAATTTTCTTTGCAGTAAAATATGCCCTTTATTATAGAAGG
GAGGATATAAGGAACCAACAGTTTGTATGAAAATAGCTCAAATAATATCTTTTATTTTGATTTTAATATTTCTTATTTTGGTTTATTAGT
GTCTTAGAACAAAATGGCCTTATATAATGAAGCCTAGTTATGCTGGACTGTTTTGATCTCTTTTAATTGTTCTGACAGATAGTTGGGGAT
GAGAGCCGAATAAGGTTTGCCTGAAATAACTGACACTATATAATTTCTGCTTTGGCAAATACTAAGTTCTAACTTGTCATTCCTGGTAGA
ACAAGCTTTATTTTTCGAGCCTAGCAATGATCTAGAAGCAGATGTTATCTCAGTGCCTTTTGCAATTTGTTGTGTGGGTTTTTTTTTTTT
TAAAGCCACACAATAATTTTGGAAAACAATGTATGGGTAGAACATGTGTCTGTTAATTGCACACAAAACCACTTTTAATGGGTACAGAGT
TAAATTTGAAGGAATAAGTTCTAGCTGAAGTATTATGAACTCCAAATAATGCTTTGAGGACCTCCAAAGGTAAAAGTACTAATCCCTTTG
GCCATTTATTGAGAGAGAGAGAGAGAGAGAGTAGGGTGACTATAGTTAATGTATTGAATGTTCTTGCTACAAATAAATGATATTTGAGCT
GATGGGTGTGCTAATTACACTGATTTGATCAATACCCATTGTATGTGAAACAGTACATACACCATATTTACAATTATGTATTTAACATTT
AAAATTTCTAATATAAGTATCTCTCAAACTGTGGATTAACTTCTTGATTTATATTTAAATATGAATCTTAAGCAAAACAGTGAAAATAAC
CATCTTGATTTAGTGTTTTTCTCCCATATGTGAATTGTATATACTTAGGTGAAGACAATAAAATCAACTGAACTGTAAGCTTAGAATAGG
ACTGAGGTAATTCTGCACAGCAACTTTACTAATGGTACATTGTTGCTTCAAAACTCTCTCTCTCTCTCTCTGTCTGTCTCAATAAATGGC
CAAAGGGATTAGTAGTTTACCTGTGGAGGTCCTCCAAGCATTATTTGGAGTTGATAATACTTCAGCTACAACCAAGCAGAATCTCTTTTT
TTTGGAGGTCCTCGAAGCATTATTTGGAGTTGATAATACTTCAGCTTCAATTTGGAGTTGATAATATTTCAGCTAGAACCTAGTAGAATC
TGTTTTTTTCCTTTGGAGGTCCTCAAAGCATTATTGGAGTTCATAATACTGAAGCTAGAACCAAGCAGAATCTGTTTTTTTCTGAGGAGT
ATCGGTAGCATAAATGTGATTATAAACATAGTACACTTGATATATGGAGGCAGTGACAGCTATTTTTACAAAATTTAAATCTGCAAATGG
ATTCAACATGTTTATGGGTTATTAAAATTGTCTGATTTCTTAGGTTCTTTATAGTACACGTGTTGAAAATAAATGATTAAGAATTGTTTC
AAGAATGCAATTATTTGATCTTAAATTTTTATGAGTTGTTAAAATAGAAATTATTTGAATATCATATATTTGGGTAACAAAAGGCACAAG
TCTGAATGTGTTTCTTTTTCTGGAATGGCCATGCCTGCCCACTTTAGAAATACAAATATCACTGGGCAGCTTGAAGCAGTTGGGAGCCTC
CAATGAGAGCAACTTGAGAGAATGATGTTGCAAGTTAGTAGGAGTAAGAAATGCTGTGTTCTCCCTGTCTTCTCTTAGGTCACATGGCAG
CCTGGCCTAAGTGATCGTGAATGGTCTATAAGGGAGGTAGCTGGGACAGGGAGGGGAGTTTGGGCTAGCCACCGTACCACTTGTCAGCGT
GAAAAGTAAGATTGTAATTGCCTGTTTAGTTTTCTGCCTCATCTTTGAAAGTTCCACCAAGCTGGGAACCTCTTGATTGTGAGGCACAAA
TGTAAGTACATCAGAAAAAAACAAAAAAACTGGCTTTAAAGCAGGAGCTTGTGGGCCCCTAAGCCAGACGGGGACTAGCTTTTGGCATTA
TATAATTAAGATTTTTTAAATCCTTAATAAGGGTTTTATTTTATTTTTATTTATTTTTTGAGACGGAGTCTTGCTCTGTGGCTCAGGCTG
GAGTACAGTGGTGCAATCTTGGCTCACTGCAACCTCTGCCTCCTGGCTGTGTTCAAGTGGTTCTGCTTCAGCCTCCCAAGTAGCTGGGGT
TAGAGCACCCTGTCACCACGCCCCGCTAATTTTTGTATTTCTAGCAGAGATGAAGTTTCACTATGTTGGCCAGGCTGGGCTCAAACTCCT
GACCTCAAGTGATCTGCCCGCCTTGGCCCCCCAAAGTGCTGTGATTACAGGCGTGAGCCGCCACGCCCAGCCTAATAAGGGTTTTAAAGA
TAATTAGTGTGTAGGTCTGTAGGCTTATGATGGTAACCACAAGTTGTTAATGGCATTGTGAAAAGTTTTTAGTTGCGCTTTATGGGTGGA
TGCTGAATTACATTTTGATTTGATACTTATAAAAAGAAAAAGTATTTCTTCAGCTTAAAAAATTGTTTAAAAGTTTGTGATCATATTGTC
TACCATGTAGCCAGCTTTCAATTATATGTAAGAGGGACTTTTTGACATTTACAAATAATACTTTGAGGTAGATATCTGAAAGCACCAGCA

>54707_54707_2_MPHOSPH9-MDM2_MPHOSPH9_chr12_123686711_ENST00000392425_MDM2_chr12_69214105_ENST00000462284_length(amino acids)=888AA_BP=493
MGFFSLSSERNESVIHYPESTEPEIQQEMSTSQPDCNVDSCSVSSGYGTFCISELNLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDG
VKNENFYIQTPEECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSWAQKLKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEK
SDFAAATHPRAFYLSKPDETPNAWMSDSGTGLTYWKLEEKDMHHSLPETLEKTFISLSSTDVSPNQSNTSNEMKLPSLKDIYYKKQRENK
QLPERNLTSASNPNHPPEVLTLDPTLHMKPKQQISGIQPHGLPNALDDRISFSPDSVLEPSMSSPSDIDSFSQASNVTSQLPGFPKYPSH
TKASPVDSWKNQTFQNESRTSSTFPSVYTITSNDISVNTVDEENTVMVASASVSQSQLPGTANSVPECISLTSLEDPVILSKIRQNLKEK
HARHIADLRAYYESEINSLKQKLEAKEISGVEDWKITNQILVDRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQ
EEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSG
DWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCW
ALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKE

--------------------------------------------------------------
>54707_54707_3_MPHOSPH9-MDM2_MPHOSPH9_chr12_123686711_ENST00000541076_MDM2_chr12_69214105_ENST00000462284_length(transcript)=8700nt_BP=1929nt
GAAGATGACACGGATTCATTTTTCTCAAACAGCCCAAGAACCTTTATTTTCCAATAAGAGAATATAACAATTTCTGTACACTATGGAAGA
GTTTGACTTGGTGAAAACCTTACACAAAACTTCATCTTCTGTAGGATCTGATGAAAATTCTCTTCATTCTCTTGGACTGAACTTAAATAC
TGATAGAAGTAGTCCCCACCTTAGTACAAATGGGGTATCCTCTTTCTCAGGGAAGACCAGACCATCTGTAATTCAAGGTACAGTTGAAGT
CCTAACTTCTTTAATGCAAGAGCTACAAAACAGTGGAAAGACTGATTCGGAACTTTGGAAAAACTGTGAGCATATACAGGAGGAGATAAA
AAATTTAGTCAAATTACAGACTAGTAGTGCTTCCTTAGCTTCCTGTGAAGGAAATTCTTCAAACAAACAAGTATCTTCGGAAAGTCAAAT
GGGTTTTTTTTCTCTAAGCAGTGAGAGAAATGAATCTGTTATCCATTATCCTGAATCCACAGAACCTGAAATACAGCAAGAAATGTCCAC
GTCACAACCAGACTGCAATGTGGATAGTTGCTCAGTAAGCAGTGGATATGGCACCTTTTGTATCTCAGAATTAAATCTGTACAAATCTAA
AGACCCTAAGGAGTTCATGGAGCACATAGATGTTCCCAAAGGACAGTATGTAGCACCTGCGGTGCCGGCTGAGTCACTTGTAGATGGTGT
GAAAAATGAGAATTTTTATATACAGACTCCTGAAGAGTGTCATGTGTCTTTAAAGGAAGATGTATCCATTTCTCCTGGTGAATTTGAACA
TAATTTTCTTGGTGAAAATAAGGTTTCTGAAGTATACAGTGGGAAAACAAATAGTAATGCTATAACATCATGGGCACAAAAACTGAAGCA
GAACCAACCAAAGAGAGCACATGTAGAAGATGGAGGTTCAAGATCTAAACAAGGAAATGAGCAAAGTAAGAAGACACCAATTGAGAAATC
TGATTTTGCTGCTGCTACACATCCTCGTGCTTTTTACCTCAGTAAACCAGATGAAACTCCAAATGCTTGGATGTCTGATTCAGGAACAGG
ATTGACTTACTGGAAACTAGAGGAAAAGGATATGCACCACTCTTTGCCTGAAACTTTAGAGAAGACGTTCATATCATTGTCTTCCACAGA
TGTGTCACCAAACCAGTCTAATACTAGTAATGAGATGAAGCTACCGTCACTGAAGGATATTTATTATAAAAAACAAAGGGAAAACAAGCA
GTTACCTGAGAGGAATCTCACTTCTGCTTCCAACCCAAATCATCCACCAGAGGTCCTGACTCTAGATCCTACGTTACACATGAAGCCAAA
GCAGCAGATTTCAGGGATTCAACCTCACGGCCTTCCGAATGCCCTTGATGACAGAATATCCTTTTCCCCGGACTCTGTTCTAGAGCCTAG
TATGTCTAGTCCCTCTGACATAGACTCATTTTCACAAGCAAGTAATGTCACTTCTCAGTTACCTGGATTTCCAAAATATCCCTCACACAC
AAAAGCTTCTCCGGTGGACTCTTGGAAAAATCAGACATTCCAAAACGAAAGTAGGACCAGTTCCACGTTTCCGTCAGTATATACCATTAC
TAGTAATGATATCTCGGTCAACACTGTAGATGAAGAAAACACTGTCATGGTTGCTTCGGCCTCAGTCAGTCAGTCCCAGCTTCCAGGTAC
AGCCAACAGTGTCCCAGAATGCATTTCATTGACTTCCTTGGAAGATCCTGTGATATTGTCTAAGATTAGGCAGAATCTGAAGGAAAAGCA
TGCTCGACACATAGCAGATCTTCGAGCTTATTATGAATCAGAAATAAATAGTTTGAAACAGAAGCTGGAGGCAAAAGAAATCTCTGGAGT
TGAAGATTGGAAGATAACCAATCAAATTCTTGTAGACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAGCAGGA
ATCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGA
AGAGAAACCTTCATCTTCACATTTGGTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCAGATGA
ATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGA
GATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCGAATCCGGATCTTGATGCTGGTGTAAGTGAACATTCAGGTGA
TTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATCTCTCGACTCAGAAGATTATAGCCTTAGTGAAGA
AGGACAAGAACTCTCAGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCATTTGAAGAAGA
TCCTGAAATTTCCTTAGCTGACTATTGGAAATGCACTTCATGCAATGAAATGAATCCCCCCCTTCCATCACATTGCAACAGATGTTGGGC
CCTTCGTGAGAATTGGCTTCCTGAAGATAAAGGGAAAGATAAAGGGGAAATCTCTGAGAAAGCCAAACTGGAAAACTCAACACAAGCTGA
AGAGGGCTTTGATGTTCCTGATTGTAAAAAAACTATAGTGAATGATTCCAGAGAGTCATGTGTTGAGGAAAATGATGATAAAATTACACA
AGCTTCACAATCACAAGAAAGTGAAGACTATTCTCAGCCATCAACTTCTAGTAGCATTATTTATAGCAGCCAAGAAGATGTGAAAGAGTT
TGAAAGGGAAGAAACCCAAGACAAAGAAGAGAGTGTGGAATCTAGTTTGCCCCTTAATGCCATTGAACCTTGTGTGATTTGTCAAGGTCG
ACCTAAAAATGGTTGCATTGTCCATGGCAAAACAGGACATCTTATGGCCTGCTTTACATGTGCAAAGAAGCTAAAGAAAAGGAATAAGCC
CTGCCCAGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGTTGACCTGTCTATAAGAGAATTATATATTTCTAAC
TATATAACCCTAGGAATTTAGACAACCTGAAATTTATTCACATATATCAAAGTGAGAAAATGCCTCAATTCACATAGATTTCTTCTCTTT
AGTATAATTGACCTACTTTGGTAGTGGAATAGTGAATACTTACTATAATTTGACTTGAATATGTAGCTCATCCTTTACACCAACTCCTAA
TTTTAAATAATTTCTACTCTGTCTTAAATGAGAAGTACTTGGTTTTTTTTTTTCTTAAATATGTATATGACATTTAAATGTAACTTATTA
TTTTTTTTGAGACCGAGTCTTGCTCTGTTACCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAAGCTCTGCCTCCCGGGTTCG
CACCATTCTCCTGCCTCAGCCTCCCAATTAGCTTGGCCTACAGTCATCTGCCACCACACCTGGCTAATTTTTTGTACTTTTAGTAGAGAC
AGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCA
TGAGCCACCGCGTCCGGCCTAAATGTCACTTAGTACCTTTGATATAAAGAGAAAATGTGTGAAAGATTTAGTTTTTTGTTTTTTTGTTTG
TTTGTTTGTTTGTTTGTTTTGAGATGAGTCTCTCTGTCGCCCAGGCTGGAGTGCAGTGTCATGATCTAGCAGTCTCCGCTTCCCGGGTTC
AAGCCATTCTCCTGGCTCAGCCTCTGGAGCAGCTGGGATTACAGGCATGCACCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGAT
AGGGTTTCACCATGTTGGCCAGGCTGGTCACGAACTCCTGACCTCAAGTGAGGTCACCCGCCTCGGCCTCCCGAAGTGCTGGGATTGCAG
ATGTGAGCCACCATGTCCAGCCAAGAATTAGTATTTAAATTTTAGATACTCTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCT
TGCTCCATCACCCATGCTAGAGTGCAGTGGAGTGATCTCGGCTCACTGCAACTTCCGCCTTCTGGGTTCAAGCTATTCTCCTGCCTCAGC
CTTCCAAGTAACTGGGATTACAGGCATGTACCACCATACCAGCTGATTTTTTTGTATTTTTAGTAAAGACAGGGTTTCACCATGTTAGCC
AGGCTGATCTTGAACTCCTAAACTCAAGTGATCTACTCACCTCAGCCTCCCAAAATGCTGGGATTACAGATGTGAGGCACCTGGCCTCAG
ATTTTTGATACTCTTAAACCTTCTGATCCTTAGTTTCTCTCTCCAAAATACTCTTTCTAGGTTAAAAAAAAAAAGGCTCTTATATTTGGT
GCTATGTAAATGAAAATGTTTTTTAGGTTTTCTTGATTTAACAATAGAGACAGGGTCTCCCTGTGTTGCCCAGGCTGGTCTCGAACTCCT
GGGCTCAAGAGATCCTCCTGTCTTGGCCTCGCAAAGTGCTAAGTAGGATTACAGGCGTTAGCCACCACACCCGGCTGTAAAAATGTACTT
ATTCTCCAGCCTCTTTTGTATAAACCATAGTAAGGGATGGGAGTAATGATGTTATCTGTGAAAATAGCCACCATTTACCCGTAAGACAAA
ACTTGTTAAAGCCTCCTGAGTCTAACCTAGATTACATCAGGCCCTTTTTCACACACAAAAAAATCCTTTATGGGATTTAATGGAATCTGT
TGTTTCCCCCTAAGTTGAAAAACAACTCTAAGACACTTTAAAGTACCTTCTTGGCCTGGGTTACATGGTTCCCAGCCTAGGTTTCAGACT
TTTGCTTAAGGCCAGTTTTAGAAACCCGTGAATTCAGAAAAGTTAATTCAGAAATTTGATAAACAGAATTGTTATTTAAAAACTAACTGG
AAAGATTGTTAAGTTCTTTCTGAATTATTCAGAAATTATGCATCATTTTCCTTCAAGAATGACAGGGTCAGCATGTGGAATTCCAAGATA
CCTCTTGACTTCCTCTCAAGCTCCGTGTTTGGTCAGTGGAGGCCCATCCGAGCTCAGCACTGAGAAGTGTTAGTTTCTTTGGGACCCATC
TACCCTGACCACATCATGATGTTCATCTGCAGCTGTTGCAAGGTGTTCAGATTGTATAAACATAAATGTCACAAAAACTTTAAAAGAAGT
GCAATTCTCAAAAGGTTAGGTGGACTAAAGCATTCTGTAAAGCAACTGCTAATAATGAGCTTACAGTGGATTTGAATTTGAAAAATATAG
TAACAAGCCTGTCAAATATCTGCAAGAACTATGGAATAAAACTACTGATGCAGTGAAGACAGTTGAAAAGATCAAACAAATGCCAAGCTA
TATTTATAATGAACAAATTCAAGAAAAAGGACTACGGAAAGTTCAGGACATCAAAGAAGTCAGGCAAAACTCATCTTGACCCCTGTTGCA
GGCAAAGGAACGCAGCTGGAAGAAAAGATGATATAACAGTTAACAGGATGCAGACATGGCAGAGGTTTCCTAAAAATCTCATTATCTATA
ACCATTTCTATATTTACATTTGAAAATCTCCTTTGGAGACTTAGAACCTCTAAATTATTGACTTATTTTTTATATAAGGTCACTCCGATG
AAAGGTGATTACAAAATCATCTACATTGCTGTCTACAAAACAGATAATATGGATGTTTGATCGCATCTCATTGTTAACTCTTTACTGATA
TGTTTGTAAATACAGAAGTGAAATGTGGACATAAAATAGTTACGCTATTTGGTTAATGGTACTAGACAACATGTAATTAATGACATTCAA
AAATTTATGGCTAGTGATATATATAAAGTAAAATTTTCTTTGCAGTAAAATATGCCCTTTATTATAGAAGGGAGGATATAAGGAACCAAC
AGTTTGTATGAAAATAGCTCAAATAATATCTTTTATTTTGATTTTAATATTTCTTATTTTGGTTTATTAGTGTCTTAGAACAAAATGGCC
TTATATAATGAAGCCTAGTTATGCTGGACTGTTTTGATCTCTTTTAATTGTTCTGACAGATAGTTGGGGATGAGAGCCGAATAAGGTTTG
CCTGAAATAACTGACACTATATAATTTCTGCTTTGGCAAATACTAAGTTCTAACTTGTCATTCCTGGTAGAACAAGCTTTATTTTTCGAG
CCTAGCAATGATCTAGAAGCAGATGTTATCTCAGTGCCTTTTGCAATTTGTTGTGTGGGTTTTTTTTTTTTTAAAGCCACACAATAATTT
TGGAAAACAATGTATGGGTAGAACATGTGTCTGTTAATTGCACACAAAACCACTTTTAATGGGTACAGAGTTAAATTTGAAGGAATAAGT
TCTAGCTGAAGTATTATGAACTCCAAATAATGCTTTGAGGACCTCCAAAGGTAAAAGTACTAATCCCTTTGGCCATTTATTGAGAGAGAG
AGAGAGAGAGAGTAGGGTGACTATAGTTAATGTATTGAATGTTCTTGCTACAAATAAATGATATTTGAGCTGATGGGTGTGCTAATTACA
CTGATTTGATCAATACCCATTGTATGTGAAACAGTACATACACCATATTTACAATTATGTATTTAACATTTAAAATTTCTAATATAAGTA
TCTCTCAAACTGTGGATTAACTTCTTGATTTATATTTAAATATGAATCTTAAGCAAAACAGTGAAAATAACCATCTTGATTTAGTGTTTT
TCTCCCATATGTGAATTGTATATACTTAGGTGAAGACAATAAAATCAACTGAACTGTAAGCTTAGAATAGGACTGAGGTAATTCTGCACA
GCAACTTTACTAATGGTACATTGTTGCTTCAAAACTCTCTCTCTCTCTCTCTGTCTGTCTCAATAAATGGCCAAAGGGATTAGTAGTTTA
CCTGTGGAGGTCCTCCAAGCATTATTTGGAGTTGATAATACTTCAGCTACAACCAAGCAGAATCTCTTTTTTTTGGAGGTCCTCGAAGCA
TTATTTGGAGTTGATAATACTTCAGCTTCAATTTGGAGTTGATAATATTTCAGCTAGAACCTAGTAGAATCTGTTTTTTTCCTTTGGAGG
TCCTCAAAGCATTATTGGAGTTCATAATACTGAAGCTAGAACCAAGCAGAATCTGTTTTTTTCTGAGGAGTATCGGTAGCATAAATGTGA
TTATAAACATAGTACACTTGATATATGGAGGCAGTGACAGCTATTTTTACAAAATTTAAATCTGCAAATGGATTCAACATGTTTATGGGT
TATTAAAATTGTCTGATTTCTTAGGTTCTTTATAGTACACGTGTTGAAAATAAATGATTAAGAATTGTTTCAAGAATGCAATTATTTGAT
CTTAAATTTTTATGAGTTGTTAAAATAGAAATTATTTGAATATCATATATTTGGGTAACAAAAGGCACAAGTCTGAATGTGTTTCTTTTT
CTGGAATGGCCATGCCTGCCCACTTTAGAAATACAAATATCACTGGGCAGCTTGAAGCAGTTGGGAGCCTCCAATGAGAGCAACTTGAGA
GAATGATGTTGCAAGTTAGTAGGAGTAAGAAATGCTGTGTTCTCCCTGTCTTCTCTTAGGTCACATGGCAGCCTGGCCTAAGTGATCGTG
AATGGTCTATAAGGGAGGTAGCTGGGACAGGGAGGGGAGTTTGGGCTAGCCACCGTACCACTTGTCAGCGTGAAAAGTAAGATTGTAATT
GCCTGTTTAGTTTTCTGCCTCATCTTTGAAAGTTCCACCAAGCTGGGAACCTCTTGATTGTGAGGCACAAATGTAAGTACATCAGAAAAA
AACAAAAAAACTGGCTTTAAAGCAGGAGCTTGTGGGCCCCTAAGCCAGACGGGGACTAGCTTTTGGCATTATATAATTAAGATTTTTTAA
ATCCTTAATAAGGGTTTTATTTTATTTTTATTTATTTTTTGAGACGGAGTCTTGCTCTGTGGCTCAGGCTGGAGTACAGTGGTGCAATCT
TGGCTCACTGCAACCTCTGCCTCCTGGCTGTGTTCAAGTGGTTCTGCTTCAGCCTCCCAAGTAGCTGGGGTTAGAGCACCCTGTCACCAC
GCCCCGCTAATTTTTGTATTTCTAGCAGAGATGAAGTTTCACTATGTTGGCCAGGCTGGGCTCAAACTCCTGACCTCAAGTGATCTGCCC
GCCTTGGCCCCCCAAAGTGCTGTGATTACAGGCGTGAGCCGCCACGCCCAGCCTAATAAGGGTTTTAAAGATAATTAGTGTGTAGGTCTG
TAGGCTTATGATGGTAACCACAAGTTGTTAATGGCATTGTGAAAAGTTTTTAGTTGCGCTTTATGGGTGGATGCTGAATTACATTTTGAT
TTGATACTTATAAAAAGAAAAAGTATTTCTTCAGCTTAAAAAATTGTTTAAAAGTTTGTGATCATATTGTCTACCATGTAGCCAGCTTTC
AATTATATGTAAGAGGGACTTTTTGACATTTACAAATAATACTTTGAGGTAGATATCTGAAAGCACCAGCACTTGGAAGGTGTTCAGAAG

>54707_54707_3_MPHOSPH9-MDM2_MPHOSPH9_chr12_123686711_ENST00000541076_MDM2_chr12_69214105_ENST00000462284_length(amino acids)=1013AA_BP=618
MYTMEEFDLVKTLHKTSSSVGSDENSLHSLGLNLNTDRSSPHLSTNGVSSFSGKTRPSVIQGTVEVLTSLMQELQNSGKTDSELWKNCEH
IQEEIKNLVKLQTSSASLASCEGNSSNKQVSSESQMGFFSLSSERNESVIHYPESTEPEIQQEMSTSQPDCNVDSCSVSSGYGTFCISEL
NLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDGVKNENFYIQTPEECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSW
AQKLKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEKSDFAAATHPRAFYLSKPDETPNAWMSDSGTGLTYWKLEEKDMHHSLPETLEKTFI
SLSSTDVSPNQSNTSNEMKLPSLKDIYYKKQRENKQLPERNLTSASNPNHPPEVLTLDPTLHMKPKQQISGIQPHGLPNALDDRISFSPD
SVLEPSMSSPSDIDSFSQASNVTSQLPGFPKYPSHTKASPVDSWKNQTFQNESRTSSTFPSVYTITSNDISVNTVDEENTVMVASASVSQ
SQLPGTANSVPECISLTSLEDPVILSKIRQNLKEKHARHIADLRAYYESEINSLKQKLEAKEISGVEDWKITNQILVDRKIYTMIYRNLV
VVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLA
LCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDT
DSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEEN
DDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKL

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Fusion Gene PPI Analysis for MPHOSPH9-MDM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMDM2chr12:123686711chr12:69214105ENST0000025814939170_30696.66666666666667437.0MTBP
TgeneMDM2chr12:123686711chr12:69214105ENST0000029925205170_3060.0322.0MTBP
TgeneMDM2chr12:123686711chr12:69214105ENST0000034880103170_3060.0266.0MTBP
TgeneMDM2chr12:123686711chr12:69214105ENST0000035629006170_3060322.0MTBP
TgeneMDM2chr12:123686711chr12:69214105ENST0000036043004170_3060.0297.0MTBP
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341203170_3060219.0MTBP
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341302170_3060.0219.0MTBP
TgeneMDM2chr12:123686711chr12:69214105ENST0000042886304170_3060271.0MTBP
TgeneMDM2chr12:123686711chr12:69214105ENST00000462284311170_306102.66666666666667498.0MTBP
TgeneMDM2chr12:123686711chr12:69214105ENST0000054082705170_3060297.0MTBP
TgeneMDM2chr12:123686711chr12:69214105ENST0000025814939150_23096.66666666666667437.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:123686711chr12:69214105ENST0000029925205150_2300.0322.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:123686711chr12:69214105ENST0000034880103150_2300.0266.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:123686711chr12:69214105ENST0000035629006150_2300322.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:123686711chr12:69214105ENST0000036043004150_2300.0297.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341203150_2300219.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341302150_2300.0219.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:123686711chr12:69214105ENST0000042886304150_2300271.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:123686711chr12:69214105ENST00000462284311150_230102.66666666666667498.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:123686711chr12:69214105ENST0000054082705150_2300297.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:123686711chr12:69214105ENST0000025814939223_23296.66666666666667437.0USP7
TgeneMDM2chr12:123686711chr12:69214105ENST0000029925205223_2320.0322.0USP7
TgeneMDM2chr12:123686711chr12:69214105ENST0000034880103223_2320.0266.0USP7
TgeneMDM2chr12:123686711chr12:69214105ENST0000035629006223_2320322.0USP7
TgeneMDM2chr12:123686711chr12:69214105ENST0000036043004223_2320.0297.0USP7
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341203223_2320219.0USP7
TgeneMDM2chr12:123686711chr12:69214105ENST0000039341302223_2320.0219.0USP7
TgeneMDM2chr12:123686711chr12:69214105ENST0000042886304223_2320271.0USP7
TgeneMDM2chr12:123686711chr12:69214105ENST00000462284311223_232102.66666666666667498.0USP7
TgeneMDM2chr12:123686711chr12:69214105ENST0000054082705223_2320297.0USP7


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MPHOSPH9-MDM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MPHOSPH9-MDM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource