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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MPHOSPH9-VPS37B (FusionGDB2 ID:54711)

Fusion Gene Summary for MPHOSPH9-VPS37B

check button Fusion gene summary
Fusion gene informationFusion gene name: MPHOSPH9-VPS37B
Fusion gene ID: 54711
HgeneTgene
Gene symbol

MPHOSPH9

VPS37B

Gene ID

10198

79720

Gene nameM-phase phosphoprotein 9VPS37B subunit of ESCRT-I
SynonymsMPP-9|MPP9-
Cytomap

12q24.31

12q24.31

Type of geneprotein-codingprotein-coding
DescriptionM-phase phosphoprotein 9vacuolar protein sorting-associated protein 37BESCRT-I complex subunit VPS37BVPS37B, ESCRT-I subunithVps37Bvacuolar protein sorting 37 homolog Bvacuolar protein sorting 37B
Modification date2020031320200313
UniProtAcc

Q99550

.
Ensembl transtripts involved in fusion geneENST00000606320, ENST00000302349, 
ENST00000392425, ENST00000541076, 
ENST00000539639, 
ENST00000267202, 
Fusion gene scores* DoF score14 X 13 X 8=14566 X 4 X 4=96
# samples 136
** MAII scorelog2(13/1456*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MPHOSPH9 [Title/Abstract] AND VPS37B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMPHOSPH9(123678933)-VPS37B(123355608), # samples:2
VPS37B(123380499)-MPHOSPH9(123665757), # samples:2
Anticipated loss of major functional domain due to fusion event.MPHOSPH9-VPS37B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MPHOSPH9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VPS37B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-E7-A4IJ-01AMPHOSPH9chr12

123678933

-VPS37Bchr12

123355608

-


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Fusion Gene ORF analysis for MPHOSPH9-VPS37B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000606320ENST00000267202MPHOSPH9chr12

123678933

-VPS37Bchr12

123355608

-
In-frameENST00000302349ENST00000267202MPHOSPH9chr12

123678933

-VPS37Bchr12

123355608

-
In-frameENST00000392425ENST00000267202MPHOSPH9chr12

123678933

-VPS37Bchr12

123355608

-
In-frameENST00000541076ENST00000267202MPHOSPH9chr12

123678933

-VPS37Bchr12

123355608

-
intron-3CDSENST00000539639ENST00000267202MPHOSPH9chr12

123678933

-VPS37Bchr12

123355608

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000302349MPHOSPH9chr12123678933-ENST00000267202VPS37Bchr12123355608-442018921072638843
ENST00000541076MPHOSPH9chr12123678933-ENST00000267202VPS37Bchr12123355608-47612233732979968
ENST00000392425MPHOSPH9chr12123678933-ENST00000267202VPS37Bchr12123355608-442018921072638843

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000302349ENST00000267202MPHOSPH9chr12123678933-VPS37Bchr12123355608-0.0011138250.99888617
ENST00000541076ENST00000267202MPHOSPH9chr12123678933-VPS37Bchr12123355608-0.0002461740.9997538
ENST00000392425ENST00000267202MPHOSPH9chr12123678933-VPS37Bchr12123355608-0.0011138250.99888617

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Fusion Genomic Features for MPHOSPH9-VPS37B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MPHOSPH9-VPS37B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:123678933/chr12:123355608)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPHOSPH9

Q99550

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneVPS37Bchr12:123678933chr12:123355608ENST0000026720204170_28037286.0Compositional biasNote=Pro-rich
TgeneVPS37Bchr12:123678933chr12:123355608ENST000002672020484_17337286.0DomainVPS37 C-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMPHOSPH9chr12:123678933chr12:123355608ENST00000302349-9201109_11745951029.0Coiled coilOntology_term=ECO:0000255
HgeneMPHOSPH9chr12:123678933chr12:123355608ENST00000302349-920609_8045951029.0Coiled coilOntology_term=ECO:0000255
HgeneMPHOSPH9chr12:123678933chr12:123355608ENST00000392425-9201109_11745951032.0Coiled coilOntology_term=ECO:0000255
HgeneMPHOSPH9chr12:123678933chr12:123355608ENST00000392425-920609_8045951032.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for MPHOSPH9-VPS37B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54711_54711_1_MPHOSPH9-VPS37B_MPHOSPH9_chr12_123678933_ENST00000302349_VPS37B_chr12_123355608_ENST00000267202_length(transcript)=4420nt_BP=1892nt
ATATACAGGAGGAGATAAAAAATTTAGTCAAATTACAGACTAGTAGTGCTTCCTTAGCTTCCTGTGAAGGAAATTCTTCAAACAAACAAG
TATCTTCGGAAAGTCAAATGGGTTTTTTTTCTCTAAGCAGTGAGAGAAATGAATCTGTTATCCATTATCCTGAATCCACAGAACCTGAAA
TACAGCAAGAAATGTCCACGTCACAACCAGACTGCAATGTGGATAGTTGCTCAGTAAGCAGTGGATATGGCACCTTTTGTATCTCAGAAT
TAAATCTGTACAAATCTAAAGACCCTAAGGAGTTCATGGAGCACATAGATGTTCCCAAAGGACAGTATGTAGCACCTGCGGTGCCGGCTG
AGTCACTTGTAGATGGTGTGAAAAATGAGAATTTTTATATACAGACTCCTGAAGAGTGTCATGTGTCTTTAAAGGAAGATGTATCCATTT
CTCCTGGTGAATTTGAACATAATTTTCTTGGTGAAAATAAGGTTTCTGAAGTATACAGTGGGAAAACAAATAGTAATGCTATAACATCAT
GGGCACAAAAACTGAAGCAGAACCAACCAAAGAGAGCACATGTAGAAGATGGAGGTTCAAGATCTAAACAAGGAAATGAGCAAAGTAAGA
AGACACCAATTGAGAAATCTGATTTTGCTGCTGCTACACATCCTCGTGCTTTTTACCTCAGTAAACCAGATGAAACTCCAAATGCTTGGA
TGTCTGATTCAGGAACAGGATTGACTTACTGGAAACTAGAGGAAAAGGATATGCACCACTCTTTGCCTGAAACTTTAGAGAAGACGTTCA
TATCATTGTCTTCCACAGATGTGTCACCAAACCAGTCTAATACTAGTAATGAGATGAAGCTACCGTCACTGAAGGATATTTATTATAAAA
AACAAAGGGAAAACAAGCAGTTACCTGAGAGGAATCTCACTTCTGCTTCCAACCCAAATCATCCACCAGAGGTCCTGACTCTAGATCCTA
CGTTACACATGAAGCCAAAGCAGCAGATTTCAGGGATTCAACCTCACGGCCTTCCGAATGCCCTTGATGACAGAATATCCTTTTCCCCGG
ACTCTGTTCTAGAGCCTAGTATGTCTAGTCCCTCTGACATAGACTCATTTTCACAAGCAAGTAATGTCACTTCTCAGTTACCTGGATTTC
CAAAATATCCCTCACACACAAAAGCTTCTCCGGTGGACTCTTGGAAAAATCAGACATTCCAAAACGAAAGTAGGACCAGTTCCACGTTTC
CGTCAGTATATACCATTACTAGTAATGATATCTCGGTCAACACTGTAGATGAAGAAAACACTGTCATGGTTGCTTCGGCCTCAGTCAGTC
AGTCCCAGCTTCCAGGTACAGCCAACAGTGTCCCAGAATGCATTTCATTGACTTCCTTGGAAGATCCTGTGATATTGTCTAAGATTAGGC
AGAATCTGAAGGAAAAGCATGCTCGACACATAGCAGATCTTCGAGCTTATTATGAATCAGAAATAAATAGTTTGAAACAGAAGCTGGAGG
CAAAAGAAATCTCTGGAGTTGAAGATTGGAAGATAACCAATCAAATTCTTGTAGACAGATGTGGCCAATTAGATAGTGCTTTGCATGAAG
CTACTAGTCGCGTGAGAACACTTGAAAATAAGAATAACTTACTGGAAATTGAAGTGAATGATTTGAGAGAACGCTTCAGTGCAGCCAGCA
GTGCTTCCAAAATTTTGCAGGAACGAATTGAAGAAATGAGAACAAGCAGTAAAGAAAAAGACAATACCATCATTCGACTAAAATCTAGAC
TGCAAGATTTAGAAGAAGCATTTGAGAATGCTTACAAACTCTCAGATGATAAAGAAGCTCAACTAAAACAAGAGAACAAAATGTTTCAAG
ATACACAGAATGTTCAGCTTAACAAAGAAATGACACTTGCCAGCAACCGGAGCCTGGCAGAAGGAAACCTTTTGTACCAGCCCCAGCTGG
ACACGTTGAAAGCACGCTTGACCCAGAAATACCAGGAACTCCAGGTTCTCTTTGAAGCCTATCAGATAAAGAAGACCAAATTAGACAGAC
AGTCTAGCAGTGCTTCCTTGGAGACCCTGTTAGCACTTCTTCAGGCAGAAGGGGCCAAGATTGAGGAAGACACTGAGAACATGGCAGAGA
AGTTTCTGGATGGAGAACTTCCTCTGGATTCCTTCATTGATGTCTATCAGAGCAAACGGAAACTGGCCCACATGCGACGGGTGAAAATCG
AGAAGCTCCAGGAGATGGTCCTAAAGGGGCAGAGACTCCCACAGGCCCTGGCCCCGCTGCCCCCCAGGCTGCCCGAACTGGCACCTACCG
CCCCCCTTCCCTACCCTGCCCCAGAGGCCAGTGGGCCTCCTGCCGTTGCACCTCGGCGCATCCCCCCCCCACCACCCCCGGTGCCTGCGG
GACGCTTAGCCACCCCGTTTACTGCGGCCATGAGTTCGGGACAGGCCGTGCCGTACCCAGGATTACAGTGCCCGCCCCTGCCCCCCCGCG
TGGGCCTCCCCACTCAGCAAGGATTCTCTTCGCAGTTCGTGTCCCCATATCCGCCACCTCTCCCTCAGAGACCCCCGCCCCGGCTCCCTC
CACACCAGCCGGGTTTCATCCTCCAGTGAGCGCCGGCGCGGTCCTTCCCGGGAGACTTCTTCCACCTGGCGTGTTGTGCTCTGCTCACGG
GAAGGAGGCTGGAGGTCCGCTCTGTGCCAAGGGCTCTGGGGCCCTGGGCCAGCGTGTCTGTCTGATTTTAGAACTGTAGGTCAGTGGTGA
GTAGTAGGAGCCCAGGCTTTGGGCATCAAGGCAGTTGTGTGTGCCGGGTTACAGCCTGACACCTGTGCGTTGCATCGGTTTGCATTATCC
GTGTGATTTCTAAGTATCTTAGCGTTGATGAACTCATGTTTGGGAAGAAATAGGCCTCTCCCCCAGTCCCATTTAGAATCGTGGTCCTTC
TGTTGCAGCTTTATTTAATGAGCATGGTTCATGATACTTATTTTATTTTCGAAAGACAGTCCTATGTGTCTCACCCACCGGCCACTGCAG
CCCTGGTGAGGGCGGGTGGGCGCCGGCCGGCCTGGAAGAGCGCCGTGGCTGGGCCACCACCTGTGGCTGCGTTGTTGCTCACTGAATCTG
TTGGGGAGAGGTCACCATAGTCACCGCCTGACCTGGCTGCTGCTCTTGCTTCAGAGCCACAAGCAAAGTTTGCACTGGGCCCACTGCCGA
GTCCAGAGGCCGGAGAACGGCCACTGGTGTGGGAGGGGAGCGCACGAGTGGGACTTTGCACAGCAAATTGTGTCCCCAGCTCCTCCTCTC
CCGCCTGCCTGGAGCCGGCCCTGAAGGTTTCTATGAAGAAATAATCCCCCAATATTTTTACTACGTGTGTGATTTTCCTGTTTTATATTG
AAAAAACTTTTTTGACACTCCCAAGACCATTCAGGGAAATTTTATAAAAAATGCAGATACTGTCTTGAGCAGATCGAAATGCCGATGAAG
TGGATGCAATTTCCTTTTGTGCAAGCAGTGCACGGTGCCCCCCCCTCGGGTGTCCGTGCTGTGCCTTAGCTTCCCCAGGTGCCGGGACTC
ACACCTGCTAGGGGCTGGGCAAGGCCCCGGCTCTGCTTTCTCTGAAGGGCTTGTCCAAGTTCATTGCCCTGTTACAGGTGGTCAAGACGT
CCGGCCGCCTTGACCCAGGCTACCCTTAGCCAATATCCTCTGCCCCTGGGTGGCTGGTGGCTGGGCCTCAGGGTGGGCAACGTTAGGGGT
TTGGCGAAAGCCCGCCCCATGGGATTGAGGGACGGGGCTGCACTCCAACCGTCTGCACCTGCTCTTCCCCCACCCCTGTGGGACCTCATC
TTCACGTGCCATGTGTGCTGAAGGCCCAGGGCCCAGCAGGGGGCAGTGGCACCTGTTGACGGAAAAGGCCGAGGTGCTTACCAGTGGACC
TTCTGGCCCGCCCCTCCCCTGTCACTTGTCGGGCATCCAGGGCCCCGACCTGTGCCTAGCCGCCAGGGTGACAGAAGGCAGAACTGAAGC
GGGGTCTGGGCCACGGGCCAGGCCACTGCCTTTTGTCCTCAGTGACCGTACATTCCTGCTCTCGGACTTGAACTCTACTGTAACTGTTTT
CTTAAAGGAAATGAAGCTGTACAGGACGATTCACTGCCATGCCAGTCAGGCGGGCTTGCCATGTTCTGTGAATCTCGAGTGAGCGGTGCC
ACCCGCCCCCATACCTCCGCCACCGGCCGCTGTCGGGGATGCCACAGCCTGCCACGGTCGCAGCCAGACGTGAGCTTGGCATTGAAGTTG
CAAAGCGGCCCCTGGCCGGGCTCGCCGTCGCTGTCCAGGGCCGTGTCCGGTGCTGTGGCTGTAAAGCTGTAGGACCCTTTTTAATAAATA

>54711_54711_1_MPHOSPH9-VPS37B_MPHOSPH9_chr12_123678933_ENST00000302349_VPS37B_chr12_123355608_ENST00000267202_length(amino acids)=843AA_BP=0
MGFFSLSSERNESVIHYPESTEPEIQQEMSTSQPDCNVDSCSVSSGYGTFCISELNLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDG
VKNENFYIQTPEECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSWAQKLKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEK
SDFAAATHPRAFYLSKPDETPNAWMSDSGTGLTYWKLEEKDMHHSLPETLEKTFISLSSTDVSPNQSNTSNEMKLPSLKDIYYKKQRENK
QLPERNLTSASNPNHPPEVLTLDPTLHMKPKQQISGIQPHGLPNALDDRISFSPDSVLEPSMSSPSDIDSFSQASNVTSQLPGFPKYPSH
TKASPVDSWKNQTFQNESRTSSTFPSVYTITSNDISVNTVDEENTVMVASASVSQSQLPGTANSVPECISLTSLEDPVILSKIRQNLKEK
HARHIADLRAYYESEINSLKQKLEAKEISGVEDWKITNQILVDRCGQLDSALHEATSRVRTLENKNNLLEIEVNDLRERFSAASSASKIL
QERIEEMRTSSKEKDNTIIRLKSRLQDLEEAFENAYKLSDDKEAQLKQENKMFQDTQNVQLNKEMTLASNRSLAEGNLLYQPQLDTLKAR
LTQKYQELQVLFEAYQIKKTKLDRQSSSASLETLLALLQAEGAKIEEDTENMAEKFLDGELPLDSFIDVYQSKRKLAHMRRVKIEKLQEM
VLKGQRLPQALAPLPPRLPELAPTAPLPYPAPEASGPPAVAPRRIPPPPPPVPAGRLATPFTAAMSSGQAVPYPGLQCPPLPPRVGLPTQ

--------------------------------------------------------------
>54711_54711_2_MPHOSPH9-VPS37B_MPHOSPH9_chr12_123678933_ENST00000392425_VPS37B_chr12_123355608_ENST00000267202_length(transcript)=4420nt_BP=1892nt
ATATACAGGAGGAGATAAAAAATTTAGTCAAATTACAGACTAGTAGTGCTTCCTTAGCTTCCTGTGAAGGAAATTCTTCAAACAAACAAG
TATCTTCGGAAAGTCAAATGGGTTTTTTTTCTCTAAGCAGTGAGAGAAATGAATCTGTTATCCATTATCCTGAATCCACAGAACCTGAAA
TACAGCAAGAAATGTCCACGTCACAACCAGACTGCAATGTGGATAGTTGCTCAGTAAGCAGTGGATATGGCACCTTTTGTATCTCAGAAT
TAAATCTGTACAAATCTAAAGACCCTAAGGAGTTCATGGAGCACATAGATGTTCCCAAAGGACAGTATGTAGCACCTGCGGTGCCGGCTG
AGTCACTTGTAGATGGTGTGAAAAATGAGAATTTTTATATACAGACTCCTGAAGAGTGTCATGTGTCTTTAAAGGAAGATGTATCCATTT
CTCCTGGTGAATTTGAACATAATTTTCTTGGTGAAAATAAGGTTTCTGAAGTATACAGTGGGAAAACAAATAGTAATGCTATAACATCAT
GGGCACAAAAACTGAAGCAGAACCAACCAAAGAGAGCACATGTAGAAGATGGAGGTTCAAGATCTAAACAAGGAAATGAGCAAAGTAAGA
AGACACCAATTGAGAAATCTGATTTTGCTGCTGCTACACATCCTCGTGCTTTTTACCTCAGTAAACCAGATGAAACTCCAAATGCTTGGA
TGTCTGATTCAGGAACAGGATTGACTTACTGGAAACTAGAGGAAAAGGATATGCACCACTCTTTGCCTGAAACTTTAGAGAAGACGTTCA
TATCATTGTCTTCCACAGATGTGTCACCAAACCAGTCTAATACTAGTAATGAGATGAAGCTACCGTCACTGAAGGATATTTATTATAAAA
AACAAAGGGAAAACAAGCAGTTACCTGAGAGGAATCTCACTTCTGCTTCCAACCCAAATCATCCACCAGAGGTCCTGACTCTAGATCCTA
CGTTACACATGAAGCCAAAGCAGCAGATTTCAGGGATTCAACCTCACGGCCTTCCGAATGCCCTTGATGACAGAATATCCTTTTCCCCGG
ACTCTGTTCTAGAGCCTAGTATGTCTAGTCCCTCTGACATAGACTCATTTTCACAAGCAAGTAATGTCACTTCTCAGTTACCTGGATTTC
CAAAATATCCCTCACACACAAAAGCTTCTCCGGTGGACTCTTGGAAAAATCAGACATTCCAAAACGAAAGTAGGACCAGTTCCACGTTTC
CGTCAGTATATACCATTACTAGTAATGATATCTCGGTCAACACTGTAGATGAAGAAAACACTGTCATGGTTGCTTCGGCCTCAGTCAGTC
AGTCCCAGCTTCCAGGTACAGCCAACAGTGTCCCAGAATGCATTTCATTGACTTCCTTGGAAGATCCTGTGATATTGTCTAAGATTAGGC
AGAATCTGAAGGAAAAGCATGCTCGACACATAGCAGATCTTCGAGCTTATTATGAATCAGAAATAAATAGTTTGAAACAGAAGCTGGAGG
CAAAAGAAATCTCTGGAGTTGAAGATTGGAAGATAACCAATCAAATTCTTGTAGACAGATGTGGCCAATTAGATAGTGCTTTGCATGAAG
CTACTAGTCGCGTGAGAACACTTGAAAATAAGAATAACTTACTGGAAATTGAAGTGAATGATTTGAGAGAACGCTTCAGTGCAGCCAGCA
GTGCTTCCAAAATTTTGCAGGAACGAATTGAAGAAATGAGAACAAGCAGTAAAGAAAAAGACAATACCATCATTCGACTAAAATCTAGAC
TGCAAGATTTAGAAGAAGCATTTGAGAATGCTTACAAACTCTCAGATGATAAAGAAGCTCAACTAAAACAAGAGAACAAAATGTTTCAAG
ATACACAGAATGTTCAGCTTAACAAAGAAATGACACTTGCCAGCAACCGGAGCCTGGCAGAAGGAAACCTTTTGTACCAGCCCCAGCTGG
ACACGTTGAAAGCACGCTTGACCCAGAAATACCAGGAACTCCAGGTTCTCTTTGAAGCCTATCAGATAAAGAAGACCAAATTAGACAGAC
AGTCTAGCAGTGCTTCCTTGGAGACCCTGTTAGCACTTCTTCAGGCAGAAGGGGCCAAGATTGAGGAAGACACTGAGAACATGGCAGAGA
AGTTTCTGGATGGAGAACTTCCTCTGGATTCCTTCATTGATGTCTATCAGAGCAAACGGAAACTGGCCCACATGCGACGGGTGAAAATCG
AGAAGCTCCAGGAGATGGTCCTAAAGGGGCAGAGACTCCCACAGGCCCTGGCCCCGCTGCCCCCCAGGCTGCCCGAACTGGCACCTACCG
CCCCCCTTCCCTACCCTGCCCCAGAGGCCAGTGGGCCTCCTGCCGTTGCACCTCGGCGCATCCCCCCCCCACCACCCCCGGTGCCTGCGG
GACGCTTAGCCACCCCGTTTACTGCGGCCATGAGTTCGGGACAGGCCGTGCCGTACCCAGGATTACAGTGCCCGCCCCTGCCCCCCCGCG
TGGGCCTCCCCACTCAGCAAGGATTCTCTTCGCAGTTCGTGTCCCCATATCCGCCACCTCTCCCTCAGAGACCCCCGCCCCGGCTCCCTC
CACACCAGCCGGGTTTCATCCTCCAGTGAGCGCCGGCGCGGTCCTTCCCGGGAGACTTCTTCCACCTGGCGTGTTGTGCTCTGCTCACGG
GAAGGAGGCTGGAGGTCCGCTCTGTGCCAAGGGCTCTGGGGCCCTGGGCCAGCGTGTCTGTCTGATTTTAGAACTGTAGGTCAGTGGTGA
GTAGTAGGAGCCCAGGCTTTGGGCATCAAGGCAGTTGTGTGTGCCGGGTTACAGCCTGACACCTGTGCGTTGCATCGGTTTGCATTATCC
GTGTGATTTCTAAGTATCTTAGCGTTGATGAACTCATGTTTGGGAAGAAATAGGCCTCTCCCCCAGTCCCATTTAGAATCGTGGTCCTTC
TGTTGCAGCTTTATTTAATGAGCATGGTTCATGATACTTATTTTATTTTCGAAAGACAGTCCTATGTGTCTCACCCACCGGCCACTGCAG
CCCTGGTGAGGGCGGGTGGGCGCCGGCCGGCCTGGAAGAGCGCCGTGGCTGGGCCACCACCTGTGGCTGCGTTGTTGCTCACTGAATCTG
TTGGGGAGAGGTCACCATAGTCACCGCCTGACCTGGCTGCTGCTCTTGCTTCAGAGCCACAAGCAAAGTTTGCACTGGGCCCACTGCCGA
GTCCAGAGGCCGGAGAACGGCCACTGGTGTGGGAGGGGAGCGCACGAGTGGGACTTTGCACAGCAAATTGTGTCCCCAGCTCCTCCTCTC
CCGCCTGCCTGGAGCCGGCCCTGAAGGTTTCTATGAAGAAATAATCCCCCAATATTTTTACTACGTGTGTGATTTTCCTGTTTTATATTG
AAAAAACTTTTTTGACACTCCCAAGACCATTCAGGGAAATTTTATAAAAAATGCAGATACTGTCTTGAGCAGATCGAAATGCCGATGAAG
TGGATGCAATTTCCTTTTGTGCAAGCAGTGCACGGTGCCCCCCCCTCGGGTGTCCGTGCTGTGCCTTAGCTTCCCCAGGTGCCGGGACTC
ACACCTGCTAGGGGCTGGGCAAGGCCCCGGCTCTGCTTTCTCTGAAGGGCTTGTCCAAGTTCATTGCCCTGTTACAGGTGGTCAAGACGT
CCGGCCGCCTTGACCCAGGCTACCCTTAGCCAATATCCTCTGCCCCTGGGTGGCTGGTGGCTGGGCCTCAGGGTGGGCAACGTTAGGGGT
TTGGCGAAAGCCCGCCCCATGGGATTGAGGGACGGGGCTGCACTCCAACCGTCTGCACCTGCTCTTCCCCCACCCCTGTGGGACCTCATC
TTCACGTGCCATGTGTGCTGAAGGCCCAGGGCCCAGCAGGGGGCAGTGGCACCTGTTGACGGAAAAGGCCGAGGTGCTTACCAGTGGACC
TTCTGGCCCGCCCCTCCCCTGTCACTTGTCGGGCATCCAGGGCCCCGACCTGTGCCTAGCCGCCAGGGTGACAGAAGGCAGAACTGAAGC
GGGGTCTGGGCCACGGGCCAGGCCACTGCCTTTTGTCCTCAGTGACCGTACATTCCTGCTCTCGGACTTGAACTCTACTGTAACTGTTTT
CTTAAAGGAAATGAAGCTGTACAGGACGATTCACTGCCATGCCAGTCAGGCGGGCTTGCCATGTTCTGTGAATCTCGAGTGAGCGGTGCC
ACCCGCCCCCATACCTCCGCCACCGGCCGCTGTCGGGGATGCCACAGCCTGCCACGGTCGCAGCCAGACGTGAGCTTGGCATTGAAGTTG
CAAAGCGGCCCCTGGCCGGGCTCGCCGTCGCTGTCCAGGGCCGTGTCCGGTGCTGTGGCTGTAAAGCTGTAGGACCCTTTTTAATAAATA

>54711_54711_2_MPHOSPH9-VPS37B_MPHOSPH9_chr12_123678933_ENST00000392425_VPS37B_chr12_123355608_ENST00000267202_length(amino acids)=843AA_BP=0
MGFFSLSSERNESVIHYPESTEPEIQQEMSTSQPDCNVDSCSVSSGYGTFCISELNLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDG
VKNENFYIQTPEECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSWAQKLKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEK
SDFAAATHPRAFYLSKPDETPNAWMSDSGTGLTYWKLEEKDMHHSLPETLEKTFISLSSTDVSPNQSNTSNEMKLPSLKDIYYKKQRENK
QLPERNLTSASNPNHPPEVLTLDPTLHMKPKQQISGIQPHGLPNALDDRISFSPDSVLEPSMSSPSDIDSFSQASNVTSQLPGFPKYPSH
TKASPVDSWKNQTFQNESRTSSTFPSVYTITSNDISVNTVDEENTVMVASASVSQSQLPGTANSVPECISLTSLEDPVILSKIRQNLKEK
HARHIADLRAYYESEINSLKQKLEAKEISGVEDWKITNQILVDRCGQLDSALHEATSRVRTLENKNNLLEIEVNDLRERFSAASSASKIL
QERIEEMRTSSKEKDNTIIRLKSRLQDLEEAFENAYKLSDDKEAQLKQENKMFQDTQNVQLNKEMTLASNRSLAEGNLLYQPQLDTLKAR
LTQKYQELQVLFEAYQIKKTKLDRQSSSASLETLLALLQAEGAKIEEDTENMAEKFLDGELPLDSFIDVYQSKRKLAHMRRVKIEKLQEM
VLKGQRLPQALAPLPPRLPELAPTAPLPYPAPEASGPPAVAPRRIPPPPPPVPAGRLATPFTAAMSSGQAVPYPGLQCPPLPPRVGLPTQ

--------------------------------------------------------------
>54711_54711_3_MPHOSPH9-VPS37B_MPHOSPH9_chr12_123678933_ENST00000541076_VPS37B_chr12_123355608_ENST00000267202_length(transcript)=4761nt_BP=2233nt
GAAGATGACACGGATTCATTTTTCTCAAACAGCCCAAGAACCTTTATTTTCCAATAAGAGAATATAACAATTTCTGTACACTATGGAAGA
GTTTGACTTGGTGAAAACCTTACACAAAACTTCATCTTCTGTAGGATCTGATGAAAATTCTCTTCATTCTCTTGGACTGAACTTAAATAC
TGATAGAAGTAGTCCCCACCTTAGTACAAATGGGGTATCCTCTTTCTCAGGGAAGACCAGACCATCTGTAATTCAAGGTACAGTTGAAGT
CCTAACTTCTTTAATGCAAGAGCTACAAAACAGTGGAAAGACTGATTCGGAACTTTGGAAAAACTGTGAGCATATACAGGAGGAGATAAA
AAATTTAGTCAAATTACAGACTAGTAGTGCTTCCTTAGCTTCCTGTGAAGGAAATTCTTCAAACAAACAAGTATCTTCGGAAAGTCAAAT
GGGTTTTTTTTCTCTAAGCAGTGAGAGAAATGAATCTGTTATCCATTATCCTGAATCCACAGAACCTGAAATACAGCAAGAAATGTCCAC
GTCACAACCAGACTGCAATGTGGATAGTTGCTCAGTAAGCAGTGGATATGGCACCTTTTGTATCTCAGAATTAAATCTGTACAAATCTAA
AGACCCTAAGGAGTTCATGGAGCACATAGATGTTCCCAAAGGACAGTATGTAGCACCTGCGGTGCCGGCTGAGTCACTTGTAGATGGTGT
GAAAAATGAGAATTTTTATATACAGACTCCTGAAGAGTGTCATGTGTCTTTAAAGGAAGATGTATCCATTTCTCCTGGTGAATTTGAACA
TAATTTTCTTGGTGAAAATAAGGTTTCTGAAGTATACAGTGGGAAAACAAATAGTAATGCTATAACATCATGGGCACAAAAACTGAAGCA
GAACCAACCAAAGAGAGCACATGTAGAAGATGGAGGTTCAAGATCTAAACAAGGAAATGAGCAAAGTAAGAAGACACCAATTGAGAAATC
TGATTTTGCTGCTGCTACACATCCTCGTGCTTTTTACCTCAGTAAACCAGATGAAACTCCAAATGCTTGGATGTCTGATTCAGGAACAGG
ATTGACTTACTGGAAACTAGAGGAAAAGGATATGCACCACTCTTTGCCTGAAACTTTAGAGAAGACGTTCATATCATTGTCTTCCACAGA
TGTGTCACCAAACCAGTCTAATACTAGTAATGAGATGAAGCTACCGTCACTGAAGGATATTTATTATAAAAAACAAAGGGAAAACAAGCA
GTTACCTGAGAGGAATCTCACTTCTGCTTCCAACCCAAATCATCCACCAGAGGTCCTGACTCTAGATCCTACGTTACACATGAAGCCAAA
GCAGCAGATTTCAGGGATTCAACCTCACGGCCTTCCGAATGCCCTTGATGACAGAATATCCTTTTCCCCGGACTCTGTTCTAGAGCCTAG
TATGTCTAGTCCCTCTGACATAGACTCATTTTCACAAGCAAGTAATGTCACTTCTCAGTTACCTGGATTTCCAAAATATCCCTCACACAC
AAAAGCTTCTCCGGTGGACTCTTGGAAAAATCAGACATTCCAAAACGAAAGTAGGACCAGTTCCACGTTTCCGTCAGTATATACCATTAC
TAGTAATGATATCTCGGTCAACACTGTAGATGAAGAAAACACTGTCATGGTTGCTTCGGCCTCAGTCAGTCAGTCCCAGCTTCCAGGTAC
AGCCAACAGTGTCCCAGAATGCATTTCATTGACTTCCTTGGAAGATCCTGTGATATTGTCTAAGATTAGGCAGAATCTGAAGGAAAAGCA
TGCTCGACACATAGCAGATCTTCGAGCTTATTATGAATCAGAAATAAATAGTTTGAAACAGAAGCTGGAGGCAAAAGAAATCTCTGGAGT
TGAAGATTGGAAGATAACCAATCAAATTCTTGTAGACAGATGTGGCCAATTAGATAGTGCTTTGCATGAAGCTACTAGTCGCGTGAGAAC
ACTTGAAAATAAGAATAACTTACTGGAAATTGAAGTGAATGATTTGAGAGAACGCTTCAGTGCAGCCAGCAGTGCTTCCAAAATTTTGCA
GGAACGAATTGAAGAAATGAGAACAAGCAGTAAAGAAAAAGACAATACCATCATTCGACTAAAATCTAGACTGCAAGATTTAGAAGAAGC
ATTTGAGAATGCTTACAAACTCTCAGATGATAAAGAAGCTCAACTAAAACAAGAGAACAAAATGTTTCAAGATACACAGAATGTTCAGCT
TAACAAAGAAATGACACTTGCCAGCAACCGGAGCCTGGCAGAAGGAAACCTTTTGTACCAGCCCCAGCTGGACACGTTGAAAGCACGCTT
GACCCAGAAATACCAGGAACTCCAGGTTCTCTTTGAAGCCTATCAGATAAAGAAGACCAAATTAGACAGACAGTCTAGCAGTGCTTCCTT
GGAGACCCTGTTAGCACTTCTTCAGGCAGAAGGGGCCAAGATTGAGGAAGACACTGAGAACATGGCAGAGAAGTTTCTGGATGGAGAACT
TCCTCTGGATTCCTTCATTGATGTCTATCAGAGCAAACGGAAACTGGCCCACATGCGACGGGTGAAAATCGAGAAGCTCCAGGAGATGGT
CCTAAAGGGGCAGAGACTCCCACAGGCCCTGGCCCCGCTGCCCCCCAGGCTGCCCGAACTGGCACCTACCGCCCCCCTTCCCTACCCTGC
CCCAGAGGCCAGTGGGCCTCCTGCCGTTGCACCTCGGCGCATCCCCCCCCCACCACCCCCGGTGCCTGCGGGACGCTTAGCCACCCCGTT
TACTGCGGCCATGAGTTCGGGACAGGCCGTGCCGTACCCAGGATTACAGTGCCCGCCCCTGCCCCCCCGCGTGGGCCTCCCCACTCAGCA
AGGATTCTCTTCGCAGTTCGTGTCCCCATATCCGCCACCTCTCCCTCAGAGACCCCCGCCCCGGCTCCCTCCACACCAGCCGGGTTTCAT
CCTCCAGTGAGCGCCGGCGCGGTCCTTCCCGGGAGACTTCTTCCACCTGGCGTGTTGTGCTCTGCTCACGGGAAGGAGGCTGGAGGTCCG
CTCTGTGCCAAGGGCTCTGGGGCCCTGGGCCAGCGTGTCTGTCTGATTTTAGAACTGTAGGTCAGTGGTGAGTAGTAGGAGCCCAGGCTT
TGGGCATCAAGGCAGTTGTGTGTGCCGGGTTACAGCCTGACACCTGTGCGTTGCATCGGTTTGCATTATCCGTGTGATTTCTAAGTATCT
TAGCGTTGATGAACTCATGTTTGGGAAGAAATAGGCCTCTCCCCCAGTCCCATTTAGAATCGTGGTCCTTCTGTTGCAGCTTTATTTAAT
GAGCATGGTTCATGATACTTATTTTATTTTCGAAAGACAGTCCTATGTGTCTCACCCACCGGCCACTGCAGCCCTGGTGAGGGCGGGTGG
GCGCCGGCCGGCCTGGAAGAGCGCCGTGGCTGGGCCACCACCTGTGGCTGCGTTGTTGCTCACTGAATCTGTTGGGGAGAGGTCACCATA
GTCACCGCCTGACCTGGCTGCTGCTCTTGCTTCAGAGCCACAAGCAAAGTTTGCACTGGGCCCACTGCCGAGTCCAGAGGCCGGAGAACG
GCCACTGGTGTGGGAGGGGAGCGCACGAGTGGGACTTTGCACAGCAAATTGTGTCCCCAGCTCCTCCTCTCCCGCCTGCCTGGAGCCGGC
CCTGAAGGTTTCTATGAAGAAATAATCCCCCAATATTTTTACTACGTGTGTGATTTTCCTGTTTTATATTGAAAAAACTTTTTTGACACT
CCCAAGACCATTCAGGGAAATTTTATAAAAAATGCAGATACTGTCTTGAGCAGATCGAAATGCCGATGAAGTGGATGCAATTTCCTTTTG
TGCAAGCAGTGCACGGTGCCCCCCCCTCGGGTGTCCGTGCTGTGCCTTAGCTTCCCCAGGTGCCGGGACTCACACCTGCTAGGGGCTGGG
CAAGGCCCCGGCTCTGCTTTCTCTGAAGGGCTTGTCCAAGTTCATTGCCCTGTTACAGGTGGTCAAGACGTCCGGCCGCCTTGACCCAGG
CTACCCTTAGCCAATATCCTCTGCCCCTGGGTGGCTGGTGGCTGGGCCTCAGGGTGGGCAACGTTAGGGGTTTGGCGAAAGCCCGCCCCA
TGGGATTGAGGGACGGGGCTGCACTCCAACCGTCTGCACCTGCTCTTCCCCCACCCCTGTGGGACCTCATCTTCACGTGCCATGTGTGCT
GAAGGCCCAGGGCCCAGCAGGGGGCAGTGGCACCTGTTGACGGAAAAGGCCGAGGTGCTTACCAGTGGACCTTCTGGCCCGCCCCTCCCC
TGTCACTTGTCGGGCATCCAGGGCCCCGACCTGTGCCTAGCCGCCAGGGTGACAGAAGGCAGAACTGAAGCGGGGTCTGGGCCACGGGCC
AGGCCACTGCCTTTTGTCCTCAGTGACCGTACATTCCTGCTCTCGGACTTGAACTCTACTGTAACTGTTTTCTTAAAGGAAATGAAGCTG
TACAGGACGATTCACTGCCATGCCAGTCAGGCGGGCTTGCCATGTTCTGTGAATCTCGAGTGAGCGGTGCCACCCGCCCCCATACCTCCG
CCACCGGCCGCTGTCGGGGATGCCACAGCCTGCCACGGTCGCAGCCAGACGTGAGCTTGGCATTGAAGTTGCAAAGCGGCCCCTGGCCGG

>54711_54711_3_MPHOSPH9-VPS37B_MPHOSPH9_chr12_123678933_ENST00000541076_VPS37B_chr12_123355608_ENST00000267202_length(amino acids)=968AA_BP=1
MYTMEEFDLVKTLHKTSSSVGSDENSLHSLGLNLNTDRSSPHLSTNGVSSFSGKTRPSVIQGTVEVLTSLMQELQNSGKTDSELWKNCEH
IQEEIKNLVKLQTSSASLASCEGNSSNKQVSSESQMGFFSLSSERNESVIHYPESTEPEIQQEMSTSQPDCNVDSCSVSSGYGTFCISEL
NLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDGVKNENFYIQTPEECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSW
AQKLKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEKSDFAAATHPRAFYLSKPDETPNAWMSDSGTGLTYWKLEEKDMHHSLPETLEKTFI
SLSSTDVSPNQSNTSNEMKLPSLKDIYYKKQRENKQLPERNLTSASNPNHPPEVLTLDPTLHMKPKQQISGIQPHGLPNALDDRISFSPD
SVLEPSMSSPSDIDSFSQASNVTSQLPGFPKYPSHTKASPVDSWKNQTFQNESRTSSTFPSVYTITSNDISVNTVDEENTVMVASASVSQ
SQLPGTANSVPECISLTSLEDPVILSKIRQNLKEKHARHIADLRAYYESEINSLKQKLEAKEISGVEDWKITNQILVDRCGQLDSALHEA
TSRVRTLENKNNLLEIEVNDLRERFSAASSASKILQERIEEMRTSSKEKDNTIIRLKSRLQDLEEAFENAYKLSDDKEAQLKQENKMFQD
TQNVQLNKEMTLASNRSLAEGNLLYQPQLDTLKARLTQKYQELQVLFEAYQIKKTKLDRQSSSASLETLLALLQAEGAKIEEDTENMAEK
FLDGELPLDSFIDVYQSKRKLAHMRRVKIEKLQEMVLKGQRLPQALAPLPPRLPELAPTAPLPYPAPEASGPPAVAPRRIPPPPPPVPAG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MPHOSPH9-VPS37B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneVPS37Bchr12:123678933chr12:123355608ENST000002672020450_17037.0286.0IST1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MPHOSPH9-VPS37B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MPHOSPH9-VPS37B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource