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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MPRIP-GPBP1L1 (FusionGDB2 ID:54778)

Fusion Gene Summary for MPRIP-GPBP1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: MPRIP-GPBP1L1
Fusion gene ID: 54778
HgeneTgene
Gene symbol

MPRIP

GPBP1L1

Gene ID

23164

60313

Gene namemyosin phosphatase Rho interacting proteinGC-rich promoter binding protein 1 like 1
SynonymsM-RIP|MRIP|RHOIP3|RIP3|p116RipSP192
Cytomap

17p11.2

1p34.1

Type of geneprotein-codingprotein-coding
Descriptionmyosin phosphatase Rho-interacting proteinRho interacting protein 3vasculin-like protein 1
Modification date2020031320200313
UniProtAcc

Q6WCQ1

Q9HC44

Ensembl transtripts involved in fusion geneENST00000395807, ENST00000341712, 
ENST00000395804, ENST00000395811, 
ENST00000444976, ENST00000395806, 
ENST00000290795, ENST00000355105, 
ENST00000479235, 
Fusion gene scores* DoF score24 X 12 X 11=31689 X 6 X 4=216
# samples 239
** MAII scorelog2(23/3168*10)=-3.78386656913523
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MPRIP [Title/Abstract] AND GPBP1L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMPRIP(16981390)-GPBP1L1(46108171), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MPRIP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GPBP1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer61NMPRIPchr17

16981390

+GPBP1L1chr1

46108171

-


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Fusion Gene ORF analysis for MPRIP-GPBP1L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000395807ENST00000290795MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
3UTR-3CDSENST00000395807ENST00000355105MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
3UTR-intronENST00000395807ENST00000479235MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
5CDS-intronENST00000341712ENST00000479235MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
5CDS-intronENST00000395804ENST00000479235MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
5CDS-intronENST00000395811ENST00000479235MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
5CDS-intronENST00000444976ENST00000479235MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
In-frameENST00000341712ENST00000290795MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
In-frameENST00000341712ENST00000355105MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
In-frameENST00000395804ENST00000290795MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
In-frameENST00000395804ENST00000355105MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
In-frameENST00000395811ENST00000290795MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
In-frameENST00000395811ENST00000355105MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
In-frameENST00000444976ENST00000290795MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
In-frameENST00000444976ENST00000355105MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
intron-3CDSENST00000395806ENST00000290795MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
intron-3CDSENST00000395806ENST00000355105MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-
intron-intronENST00000395806ENST00000479235MPRIPchr17

16981390

+GPBP1L1chr1

46108171

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000395811MPRIPchr1716981390+ENST00000290795GPBP1L1chr146108171-2256356891303404
ENST00000395811MPRIPchr1716981390+ENST00000355105GPBP1L1chr146108171-2254356891303404
ENST00000444976MPRIPchr1716981390+ENST00000290795GPBP1L1chr146108171-2247347801294404
ENST00000444976MPRIPchr1716981390+ENST00000355105GPBP1L1chr146108171-2245347801294404
ENST00000395804MPRIPchr1716981390+ENST00000290795GPBP1L1chr146108171-2223323561270404
ENST00000395804MPRIPchr1716981390+ENST00000355105GPBP1L1chr146108171-2221323561270404
ENST00000341712MPRIPchr1716981390+ENST00000290795GPBP1L1chr146108171-216726701214404
ENST00000341712MPRIPchr1716981390+ENST00000355105GPBP1L1chr146108171-216526701214404

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000395811ENST00000290795MPRIPchr1716981390+GPBP1L1chr146108171-0.0021393770.9978606
ENST00000395811ENST00000355105MPRIPchr1716981390+GPBP1L1chr146108171-0.0021278320.9978721
ENST00000444976ENST00000290795MPRIPchr1716981390+GPBP1L1chr146108171-0.0021256470.9978744
ENST00000444976ENST00000355105MPRIPchr1716981390+GPBP1L1chr146108171-0.0021189680.997881
ENST00000395804ENST00000290795MPRIPchr1716981390+GPBP1L1chr146108171-0.0019360050.998064
ENST00000395804ENST00000355105MPRIPchr1716981390+GPBP1L1chr146108171-0.0019367510.99806327
ENST00000341712ENST00000290795MPRIPchr1716981390+GPBP1L1chr146108171-0.0015115310.9984884
ENST00000341712ENST00000355105MPRIPchr1716981390+GPBP1L1chr146108171-0.0015111180.9984889

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Fusion Genomic Features for MPRIP-GPBP1L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MPRIP-GPBP1L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:16981390/chr1:46108171)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPRIP

Q6WCQ1

GPBP1L1

Q9HC44

FUNCTION: Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.FUNCTION: Possible transcription factor. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMPRIPchr17:16981390chr1:46108171ENST00000341712+324673_977891231.0Coiled coilOntology_term=ECO:0000255
HgeneMPRIPchr17:16981390chr1:46108171ENST00000395804+323673_977891026.0Coiled coilOntology_term=ECO:0000255
HgeneMPRIPchr17:16981390chr1:46108171ENST00000395811+323673_977891039.0Coiled coilOntology_term=ECO:0000255
HgeneMPRIPchr17:16981390chr1:46108171ENST00000444976+322673_977891001.0Coiled coilOntology_term=ECO:0000255
HgeneMPRIPchr17:16981390chr1:46108171ENST00000341712+324179_252891231.0Compositional biasNote=Ser-rich
HgeneMPRIPchr17:16981390chr1:46108171ENST00000395804+323179_252891026.0Compositional biasNote=Ser-rich
HgeneMPRIPchr17:16981390chr1:46108171ENST00000395811+323179_252891039.0Compositional biasNote=Ser-rich
HgeneMPRIPchr17:16981390chr1:46108171ENST00000444976+322179_252891001.0Compositional biasNote=Ser-rich
HgeneMPRIPchr17:16981390chr1:46108171ENST00000341712+324387_483891231.0DomainPH 2
HgeneMPRIPchr17:16981390chr1:46108171ENST00000341712+32443_150891231.0DomainPH 1
HgeneMPRIPchr17:16981390chr1:46108171ENST00000395804+323387_483891026.0DomainPH 2
HgeneMPRIPchr17:16981390chr1:46108171ENST00000395804+32343_150891026.0DomainPH 1
HgeneMPRIPchr17:16981390chr1:46108171ENST00000395811+323387_483891039.0DomainPH 2
HgeneMPRIPchr17:16981390chr1:46108171ENST00000395811+32343_150891039.0DomainPH 1
HgeneMPRIPchr17:16981390chr1:46108171ENST00000444976+322387_483891001.0DomainPH 2
HgeneMPRIPchr17:16981390chr1:46108171ENST00000444976+32243_150891001.0DomainPH 1


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Fusion Gene Sequence for MPRIP-GPBP1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>54778_54778_1_MPRIP-GPBP1L1_MPRIP_chr17_16981390_ENST00000341712_GPBP1L1_chr1_46108171_ENST00000290795_length(transcript)=2167nt_BP=267nt
ATGTCGGCAGCCAAGGAGAACCCGTGCAGGAAATTCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAG
TCGCATCTGCTCAACGACGAGGACCTGACGCAGGCAAAACCCATTTATGGCGGTTGGCTGCTCCTGGCTCCAGATGGGACCGACTTTGAC
AACCCAGTGCACCGGTCTCGGAAATGGCAGCGACGGTTCTTCATCCTTTACGAGCACGGCCTCTTGCGCTACGCCCTGGATGAGATGCCT
TCCTTGAATCCAGAAGCTGGCAAACAGCATCAGCCATGCAGACCTATTGGGACACCTTCTGGAGTATGGGAAAACCCGCCTAGTGCCAAG
CAACCCTCCAAGATGCTAGTTATCAAAAAAGTTTCCAAAGAGGATCCTGCTGCTGCCTTCTCTGCTGCATTCACCTCACCAGGATCTCAC
CATGCAAATGGGAACAAATTGTCATCCGTGGTTCCAAGTGTCTATAAGAACCTGGTTCCTAAGCCTGTACCACCTCCTTCCAAGCCTAAT
GCATGGAAAGCTAACAGGATGGAGCACAAGTCAGGATCCCTTTCCTCTAGCCGGGAGTCTGCTTTTACCAGTCCAATCTCTGTTACCAAA
CCAGTGGTACTGGCTAGTGGTGCAGCTCTGAGTTCTCCCAAAGAGAGTCCCTCCAGCACCACCCCTCCAATTGAGATCAGCTCCTCTCGT
CTGACCAAGTTGACCCGCCGAACCACCGACAGGAAGAGTGAGTTCCTGAAAACTCTGAAGGATGACCGGAATGGAGACTTCTCAGAGAAT
AGAGACTGTGACAAGCTGGAAGATTTGGAGGACAACAGCACACCTGAACCAAAGGAAAATGGGGAGGAAGGCTGTCATCAAAATGGTCTT
GCCCTCCCTGTAGTGGAAGAAGGGGAGGTTCTCTCACACTCTCTAGAAGCAGAGCACAGGTTATTGAAAGCTATGGGTTGGCAGGAATAT
CCTGAAAATGATGAGAATTGCCTTCCCCTCACAGAGGATGAGCTCAAAGAGTTCCACATGAAGACAGAGCAGCTGAGAAGAAATGGCTTT
GGAAAGAATGGCTTCTTGCAGAGCCGCAGTTCCAGTCTGTTCTCCCCTTGGAGAAGCACTTGCAAAGCAGAGTTTGAGGACTCAGACACC
GAAACCAGTAGCAGTGAAACATCAGATGACGATGCCTGGAAGTAGGCATATAAATGCTCACAGTTAAATCTGACCCAGTAAACTCTGTGT
GTTTAGGGAGTATACAAAAGAAATCGTTCTTTTCCTTTTCTTATGTTGTTGAATACTTCATTCACAAGGGAAATAATCATATCCCAAAGA
GAGAGCAATTGGCTTGTTTTGCTTTTGTTATTGTTCTTCCCTGTTATCTGCTTTATAGAGAGAAGTTTGTGTGGTGGGACAGATTTTTTA
AACACACTCACACACACACACACATACACACCCAGTATATATGGGGCGATGCACAGGTAGGAGCTGGCAGTGCAGGGAAGAGGAGACACT
GGTCTGCAGCAACAGCTTCTACTACCAGCCCTTGGGGCACTCACCCCTGTGATCAAGCAATCATTGTCAATGACAAAGTGACTATTGAAG
TTATAATTGTATTAAATTAATGCTAATAATTTGGATATTTTATTTTATTTTTGGCTGCTCGGGTAACTTTAGCCCTTAACCAAGCATATG
TGGGTTTTTTTGGTTGTTTTTTTTTGTTTTTTTTTTCTTTTTCCTTTTTGGGTACAGCTGTAAAATATTTGGATATAGGAAATGTTGTGT
TATTCTTGCAGCCTTGATATTCAGGGTGGATTGTAAAATATAAATTTTTGTGAGATTTCAAAGATTAAGATTATTTTGATAACATTATTT
ACAGATTTAAAAGATGTGGTTATCACAAGTCTCGAGGGGGAAACTACTGCATAAAATAACTAACTTGGAATAAATATTTTGCATCAGTTT
GGATTGTCTTGTGTAAGAAGTATATTTTCTTTAAAATTAGATGAGTGGATTCTTTTTTAGGGGAAATATTTTTAGAAGTTGGGGGGAAAT
GTGAATTCAGACACAACTGTTTCTCTATTTTAGCAGATACTTTTTTGATGCAGAAAAACCTGTGCAATAAATTACCAGTAATAAAGTCAG

>54778_54778_1_MPRIP-GPBP1L1_MPRIP_chr17_16981390_ENST00000341712_GPBP1L1_chr1_46108171_ENST00000290795_length(amino acids)=404AA_BP=89
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP
SLNPEAGKQHQPCRPIGTPSGVWENPPSAKQPSKMLVIKKVSKEDPAAAFSAAFTSPGSHHANGNKLSSVVPSVYKNLVPKPVPPPSKPN
AWKANRMEHKSGSLSSSRESAFTSPISVTKPVVLASGAALSSPKESPSSTTPPIEISSSRLTKLTRRTTDRKSEFLKTLKDDRNGDFSEN
RDCDKLEDLEDNSTPEPKENGEEGCHQNGLALPVVEEGEVLSHSLEAEHRLLKAMGWQEYPENDENCLPLTEDELKEFHMKTEQLRRNGF

--------------------------------------------------------------
>54778_54778_2_MPRIP-GPBP1L1_MPRIP_chr17_16981390_ENST00000341712_GPBP1L1_chr1_46108171_ENST00000355105_length(transcript)=2165nt_BP=267nt
ATGTCGGCAGCCAAGGAGAACCCGTGCAGGAAATTCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAG
TCGCATCTGCTCAACGACGAGGACCTGACGCAGGCAAAACCCATTTATGGCGGTTGGCTGCTCCTGGCTCCAGATGGGACCGACTTTGAC
AACCCAGTGCACCGGTCTCGGAAATGGCAGCGACGGTTCTTCATCCTTTACGAGCACGGCCTCTTGCGCTACGCCCTGGATGAGATGCCT
TCCTTGAATCCAGAAGCTGGCAAACAGCATCAGCCATGCAGACCTATTGGGACACCTTCTGGAGTATGGGAAAACCCGCCTAGTGCCAAG
CAACCCTCCAAGATGCTAGTTATCAAAAAAGTTTCCAAAGAGGATCCTGCTGCTGCCTTCTCTGCTGCATTCACCTCACCAGGATCTCAC
CATGCAAATGGGAACAAATTGTCATCCGTGGTTCCAAGTGTCTATAAGAACCTGGTTCCTAAGCCTGTACCACCTCCTTCCAAGCCTAAT
GCATGGAAAGCTAACAGGATGGAGCACAAGTCAGGATCCCTTTCCTCTAGCCGGGAGTCTGCTTTTACCAGTCCAATCTCTGTTACCAAA
CCAGTGGTACTGGCTAGTGGTGCAGCTCTGAGTTCTCCCAAAGAGAGTCCCTCCAGCACCACCCCTCCAATTGAGATCAGCTCCTCTCGT
CTGACCAAGTTGACCCGCCGAACCACCGACAGGAAGAGTGAGTTCCTGAAAACTCTGAAGGATGACCGGAATGGAGACTTCTCAGAGAAT
AGAGACTGTGACAAGCTGGAAGATTTGGAGGACAACAGCACACCTGAACCAAAGGAAAATGGGGAGGAAGGCTGTCATCAAAATGGTCTT
GCCCTCCCTGTAGTGGAAGAAGGGGAGGTTCTCTCACACTCTCTAGAAGCAGAGCACAGGTTATTGAAAGCTATGGGTTGGCAGGAATAT
CCTGAAAATGATGAGAATTGCCTTCCCCTCACAGAGGATGAGCTCAAAGAGTTCCACATGAAGACAGAGCAGCTGAGAAGAAATGGCTTT
GGAAAGAATGGCTTCTTGCAGAGCCGCAGTTCCAGTCTGTTCTCCCCTTGGAGAAGCACTTGCAAAGCAGAGTTTGAGGACTCAGACACC
GAAACCAGTAGCAGTGAAACATCAGATGACGATGCCTGGAAGTAGGCATATAAATGCTCACAGTTAAATCTGACCCAGTAAACTCTGTGT
GTTTAGGGAGTATACAAAAGAAATCGTTCTTTTCCTTTTCTTATGTTGTTGAATACTTCATTCACAAGGGAAATAATCATATCCCAAAGA
GAGAGCAATTGGCTTGTTTTGCTTTTGTTATTGTTCTTCCCTGTTATCTGCTTTATAGAGAGAAGTTTGTGTGGTGGGACAGATTTTTTA
AACACACTCACACACACACACACATACACACCCAGTATATATGGGGCGATGCACAGGTAGGAGCTGGCAGTGCAGGGAAGAGGAGACACT
GGTCTGCAGCAACAGCTTCTACTACCAGCCCTTGGGGCACTCACCCCTGTGATCAAGCAATCATTGTCAATGACAAAGTGACTATTGAAG
TTATAATTGTATTAAATTAATGCTAATAATTTGGATATTTTATTTTATTTTTGGCTGCTCGGGTAACTTTAGCCCTTAACCAAGCATATG
TGGGTTTTTTTGGTTGTTTTTTTTTGTTTTTTTTTTCTTTTTCCTTTTTGGGTACAGCTGTAAAATATTTGGATATAGGAAATGTTGTGT
TATTCTTGCAGCCTTGATATTCAGGGTGGATTGTAAAATATAAATTTTTGTGAGATTTCAAAGATTAAGATTATTTTGATAACATTATTT
ACAGATTTAAAAGATGTGGTTATCACAAGTCTCGAGGGGGAAACTACTGCATAAAATAACTAACTTGGAATAAATATTTTGCATCAGTTT
GGATTGTCTTGTGTAAGAAGTATATTTTCTTTAAAATTAGATGAGTGGATTCTTTTTTAGGGGAAATATTTTTAGAAGTTGGGGGGAAAT
GTGAATTCAGACACAACTGTTTCTCTATTTTAGCAGATACTTTTTTGATGCAGAAAAACCTGTGCAATAAATTACCAGTAATAAAGTCAG

>54778_54778_2_MPRIP-GPBP1L1_MPRIP_chr17_16981390_ENST00000341712_GPBP1L1_chr1_46108171_ENST00000355105_length(amino acids)=404AA_BP=89
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP
SLNPEAGKQHQPCRPIGTPSGVWENPPSAKQPSKMLVIKKVSKEDPAAAFSAAFTSPGSHHANGNKLSSVVPSVYKNLVPKPVPPPSKPN
AWKANRMEHKSGSLSSSRESAFTSPISVTKPVVLASGAALSSPKESPSSTTPPIEISSSRLTKLTRRTTDRKSEFLKTLKDDRNGDFSEN
RDCDKLEDLEDNSTPEPKENGEEGCHQNGLALPVVEEGEVLSHSLEAEHRLLKAMGWQEYPENDENCLPLTEDELKEFHMKTEQLRRNGF

--------------------------------------------------------------
>54778_54778_3_MPRIP-GPBP1L1_MPRIP_chr17_16981390_ENST00000395804_GPBP1L1_chr1_46108171_ENST00000290795_length(transcript)=2223nt_BP=323nt
GCCAGGCCGGCCAGGCCTGCGCCGCCGCCGCCGCCGCCGTCGCCGCCGCGCCGACCATGTCGGCAGCCAAGGAGAACCCGTGCAGGAAAT
TCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAGTCGCATCTGCTCAACGACGAGGACCTGACGCAGG
CAAAACCCATTTATGGCGGTTGGCTGCTCCTGGCTCCAGATGGGACCGACTTTGACAACCCAGTGCACCGGTCTCGGAAATGGCAGCGAC
GGTTCTTCATCCTTTACGAGCACGGCCTCTTGCGCTACGCCCTGGATGAGATGCCTTCCTTGAATCCAGAAGCTGGCAAACAGCATCAGC
CATGCAGACCTATTGGGACACCTTCTGGAGTATGGGAAAACCCGCCTAGTGCCAAGCAACCCTCCAAGATGCTAGTTATCAAAAAAGTTT
CCAAAGAGGATCCTGCTGCTGCCTTCTCTGCTGCATTCACCTCACCAGGATCTCACCATGCAAATGGGAACAAATTGTCATCCGTGGTTC
CAAGTGTCTATAAGAACCTGGTTCCTAAGCCTGTACCACCTCCTTCCAAGCCTAATGCATGGAAAGCTAACAGGATGGAGCACAAGTCAG
GATCCCTTTCCTCTAGCCGGGAGTCTGCTTTTACCAGTCCAATCTCTGTTACCAAACCAGTGGTACTGGCTAGTGGTGCAGCTCTGAGTT
CTCCCAAAGAGAGTCCCTCCAGCACCACCCCTCCAATTGAGATCAGCTCCTCTCGTCTGACCAAGTTGACCCGCCGAACCACCGACAGGA
AGAGTGAGTTCCTGAAAACTCTGAAGGATGACCGGAATGGAGACTTCTCAGAGAATAGAGACTGTGACAAGCTGGAAGATTTGGAGGACA
ACAGCACACCTGAACCAAAGGAAAATGGGGAGGAAGGCTGTCATCAAAATGGTCTTGCCCTCCCTGTAGTGGAAGAAGGGGAGGTTCTCT
CACACTCTCTAGAAGCAGAGCACAGGTTATTGAAAGCTATGGGTTGGCAGGAATATCCTGAAAATGATGAGAATTGCCTTCCCCTCACAG
AGGATGAGCTCAAAGAGTTCCACATGAAGACAGAGCAGCTGAGAAGAAATGGCTTTGGAAAGAATGGCTTCTTGCAGAGCCGCAGTTCCA
GTCTGTTCTCCCCTTGGAGAAGCACTTGCAAAGCAGAGTTTGAGGACTCAGACACCGAAACCAGTAGCAGTGAAACATCAGATGACGATG
CCTGGAAGTAGGCATATAAATGCTCACAGTTAAATCTGACCCAGTAAACTCTGTGTGTTTAGGGAGTATACAAAAGAAATCGTTCTTTTC
CTTTTCTTATGTTGTTGAATACTTCATTCACAAGGGAAATAATCATATCCCAAAGAGAGAGCAATTGGCTTGTTTTGCTTTTGTTATTGT
TCTTCCCTGTTATCTGCTTTATAGAGAGAAGTTTGTGTGGTGGGACAGATTTTTTAAACACACTCACACACACACACACATACACACCCA
GTATATATGGGGCGATGCACAGGTAGGAGCTGGCAGTGCAGGGAAGAGGAGACACTGGTCTGCAGCAACAGCTTCTACTACCAGCCCTTG
GGGCACTCACCCCTGTGATCAAGCAATCATTGTCAATGACAAAGTGACTATTGAAGTTATAATTGTATTAAATTAATGCTAATAATTTGG
ATATTTTATTTTATTTTTGGCTGCTCGGGTAACTTTAGCCCTTAACCAAGCATATGTGGGTTTTTTTGGTTGTTTTTTTTTGTTTTTTTT
TTCTTTTTCCTTTTTGGGTACAGCTGTAAAATATTTGGATATAGGAAATGTTGTGTTATTCTTGCAGCCTTGATATTCAGGGTGGATTGT
AAAATATAAATTTTTGTGAGATTTCAAAGATTAAGATTATTTTGATAACATTATTTACAGATTTAAAAGATGTGGTTATCACAAGTCTCG
AGGGGGAAACTACTGCATAAAATAACTAACTTGGAATAAATATTTTGCATCAGTTTGGATTGTCTTGTGTAAGAAGTATATTTTCTTTAA
AATTAGATGAGTGGATTCTTTTTTAGGGGAAATATTTTTAGAAGTTGGGGGGAAATGTGAATTCAGACACAACTGTTTCTCTATTTTAGC

>54778_54778_3_MPRIP-GPBP1L1_MPRIP_chr17_16981390_ENST00000395804_GPBP1L1_chr1_46108171_ENST00000290795_length(amino acids)=404AA_BP=89
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP
SLNPEAGKQHQPCRPIGTPSGVWENPPSAKQPSKMLVIKKVSKEDPAAAFSAAFTSPGSHHANGNKLSSVVPSVYKNLVPKPVPPPSKPN
AWKANRMEHKSGSLSSSRESAFTSPISVTKPVVLASGAALSSPKESPSSTTPPIEISSSRLTKLTRRTTDRKSEFLKTLKDDRNGDFSEN
RDCDKLEDLEDNSTPEPKENGEEGCHQNGLALPVVEEGEVLSHSLEAEHRLLKAMGWQEYPENDENCLPLTEDELKEFHMKTEQLRRNGF

--------------------------------------------------------------
>54778_54778_4_MPRIP-GPBP1L1_MPRIP_chr17_16981390_ENST00000395804_GPBP1L1_chr1_46108171_ENST00000355105_length(transcript)=2221nt_BP=323nt
GCCAGGCCGGCCAGGCCTGCGCCGCCGCCGCCGCCGCCGTCGCCGCCGCGCCGACCATGTCGGCAGCCAAGGAGAACCCGTGCAGGAAAT
TCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAGTCGCATCTGCTCAACGACGAGGACCTGACGCAGG
CAAAACCCATTTATGGCGGTTGGCTGCTCCTGGCTCCAGATGGGACCGACTTTGACAACCCAGTGCACCGGTCTCGGAAATGGCAGCGAC
GGTTCTTCATCCTTTACGAGCACGGCCTCTTGCGCTACGCCCTGGATGAGATGCCTTCCTTGAATCCAGAAGCTGGCAAACAGCATCAGC
CATGCAGACCTATTGGGACACCTTCTGGAGTATGGGAAAACCCGCCTAGTGCCAAGCAACCCTCCAAGATGCTAGTTATCAAAAAAGTTT
CCAAAGAGGATCCTGCTGCTGCCTTCTCTGCTGCATTCACCTCACCAGGATCTCACCATGCAAATGGGAACAAATTGTCATCCGTGGTTC
CAAGTGTCTATAAGAACCTGGTTCCTAAGCCTGTACCACCTCCTTCCAAGCCTAATGCATGGAAAGCTAACAGGATGGAGCACAAGTCAG
GATCCCTTTCCTCTAGCCGGGAGTCTGCTTTTACCAGTCCAATCTCTGTTACCAAACCAGTGGTACTGGCTAGTGGTGCAGCTCTGAGTT
CTCCCAAAGAGAGTCCCTCCAGCACCACCCCTCCAATTGAGATCAGCTCCTCTCGTCTGACCAAGTTGACCCGCCGAACCACCGACAGGA
AGAGTGAGTTCCTGAAAACTCTGAAGGATGACCGGAATGGAGACTTCTCAGAGAATAGAGACTGTGACAAGCTGGAAGATTTGGAGGACA
ACAGCACACCTGAACCAAAGGAAAATGGGGAGGAAGGCTGTCATCAAAATGGTCTTGCCCTCCCTGTAGTGGAAGAAGGGGAGGTTCTCT
CACACTCTCTAGAAGCAGAGCACAGGTTATTGAAAGCTATGGGTTGGCAGGAATATCCTGAAAATGATGAGAATTGCCTTCCCCTCACAG
AGGATGAGCTCAAAGAGTTCCACATGAAGACAGAGCAGCTGAGAAGAAATGGCTTTGGAAAGAATGGCTTCTTGCAGAGCCGCAGTTCCA
GTCTGTTCTCCCCTTGGAGAAGCACTTGCAAAGCAGAGTTTGAGGACTCAGACACCGAAACCAGTAGCAGTGAAACATCAGATGACGATG
CCTGGAAGTAGGCATATAAATGCTCACAGTTAAATCTGACCCAGTAAACTCTGTGTGTTTAGGGAGTATACAAAAGAAATCGTTCTTTTC
CTTTTCTTATGTTGTTGAATACTTCATTCACAAGGGAAATAATCATATCCCAAAGAGAGAGCAATTGGCTTGTTTTGCTTTTGTTATTGT
TCTTCCCTGTTATCTGCTTTATAGAGAGAAGTTTGTGTGGTGGGACAGATTTTTTAAACACACTCACACACACACACACATACACACCCA
GTATATATGGGGCGATGCACAGGTAGGAGCTGGCAGTGCAGGGAAGAGGAGACACTGGTCTGCAGCAACAGCTTCTACTACCAGCCCTTG
GGGCACTCACCCCTGTGATCAAGCAATCATTGTCAATGACAAAGTGACTATTGAAGTTATAATTGTATTAAATTAATGCTAATAATTTGG
ATATTTTATTTTATTTTTGGCTGCTCGGGTAACTTTAGCCCTTAACCAAGCATATGTGGGTTTTTTTGGTTGTTTTTTTTTGTTTTTTTT
TTCTTTTTCCTTTTTGGGTACAGCTGTAAAATATTTGGATATAGGAAATGTTGTGTTATTCTTGCAGCCTTGATATTCAGGGTGGATTGT
AAAATATAAATTTTTGTGAGATTTCAAAGATTAAGATTATTTTGATAACATTATTTACAGATTTAAAAGATGTGGTTATCACAAGTCTCG
AGGGGGAAACTACTGCATAAAATAACTAACTTGGAATAAATATTTTGCATCAGTTTGGATTGTCTTGTGTAAGAAGTATATTTTCTTTAA
AATTAGATGAGTGGATTCTTTTTTAGGGGAAATATTTTTAGAAGTTGGGGGGAAATGTGAATTCAGACACAACTGTTTCTCTATTTTAGC

>54778_54778_4_MPRIP-GPBP1L1_MPRIP_chr17_16981390_ENST00000395804_GPBP1L1_chr1_46108171_ENST00000355105_length(amino acids)=404AA_BP=89
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP
SLNPEAGKQHQPCRPIGTPSGVWENPPSAKQPSKMLVIKKVSKEDPAAAFSAAFTSPGSHHANGNKLSSVVPSVYKNLVPKPVPPPSKPN
AWKANRMEHKSGSLSSSRESAFTSPISVTKPVVLASGAALSSPKESPSSTTPPIEISSSRLTKLTRRTTDRKSEFLKTLKDDRNGDFSEN
RDCDKLEDLEDNSTPEPKENGEEGCHQNGLALPVVEEGEVLSHSLEAEHRLLKAMGWQEYPENDENCLPLTEDELKEFHMKTEQLRRNGF

--------------------------------------------------------------
>54778_54778_5_MPRIP-GPBP1L1_MPRIP_chr17_16981390_ENST00000395811_GPBP1L1_chr1_46108171_ENST00000290795_length(transcript)=2256nt_BP=356nt
GCGGCCGCGCTGAGCCCCTAGCCCGCCGGGAGCGCCAGGCCGGCCAGGCCTGCGCCGCCGCCGCCGCCGCCGTCGCCGCCGCGCCGACCA
TGTCGGCAGCCAAGGAGAACCCGTGCAGGAAATTCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAGT
CGCATCTGCTCAACGACGAGGACCTGACGCAGGCAAAACCCATTTATGGCGGTTGGCTGCTCCTGGCTCCAGATGGGACCGACTTTGACA
ACCCAGTGCACCGGTCTCGGAAATGGCAGCGACGGTTCTTCATCCTTTACGAGCACGGCCTCTTGCGCTACGCCCTGGATGAGATGCCTT
CCTTGAATCCAGAAGCTGGCAAACAGCATCAGCCATGCAGACCTATTGGGACACCTTCTGGAGTATGGGAAAACCCGCCTAGTGCCAAGC
AACCCTCCAAGATGCTAGTTATCAAAAAAGTTTCCAAAGAGGATCCTGCTGCTGCCTTCTCTGCTGCATTCACCTCACCAGGATCTCACC
ATGCAAATGGGAACAAATTGTCATCCGTGGTTCCAAGTGTCTATAAGAACCTGGTTCCTAAGCCTGTACCACCTCCTTCCAAGCCTAATG
CATGGAAAGCTAACAGGATGGAGCACAAGTCAGGATCCCTTTCCTCTAGCCGGGAGTCTGCTTTTACCAGTCCAATCTCTGTTACCAAAC
CAGTGGTACTGGCTAGTGGTGCAGCTCTGAGTTCTCCCAAAGAGAGTCCCTCCAGCACCACCCCTCCAATTGAGATCAGCTCCTCTCGTC
TGACCAAGTTGACCCGCCGAACCACCGACAGGAAGAGTGAGTTCCTGAAAACTCTGAAGGATGACCGGAATGGAGACTTCTCAGAGAATA
GAGACTGTGACAAGCTGGAAGATTTGGAGGACAACAGCACACCTGAACCAAAGGAAAATGGGGAGGAAGGCTGTCATCAAAATGGTCTTG
CCCTCCCTGTAGTGGAAGAAGGGGAGGTTCTCTCACACTCTCTAGAAGCAGAGCACAGGTTATTGAAAGCTATGGGTTGGCAGGAATATC
CTGAAAATGATGAGAATTGCCTTCCCCTCACAGAGGATGAGCTCAAAGAGTTCCACATGAAGACAGAGCAGCTGAGAAGAAATGGCTTTG
GAAAGAATGGCTTCTTGCAGAGCCGCAGTTCCAGTCTGTTCTCCCCTTGGAGAAGCACTTGCAAAGCAGAGTTTGAGGACTCAGACACCG
AAACCAGTAGCAGTGAAACATCAGATGACGATGCCTGGAAGTAGGCATATAAATGCTCACAGTTAAATCTGACCCAGTAAACTCTGTGTG
TTTAGGGAGTATACAAAAGAAATCGTTCTTTTCCTTTTCTTATGTTGTTGAATACTTCATTCACAAGGGAAATAATCATATCCCAAAGAG
AGAGCAATTGGCTTGTTTTGCTTTTGTTATTGTTCTTCCCTGTTATCTGCTTTATAGAGAGAAGTTTGTGTGGTGGGACAGATTTTTTAA
ACACACTCACACACACACACACATACACACCCAGTATATATGGGGCGATGCACAGGTAGGAGCTGGCAGTGCAGGGAAGAGGAGACACTG
GTCTGCAGCAACAGCTTCTACTACCAGCCCTTGGGGCACTCACCCCTGTGATCAAGCAATCATTGTCAATGACAAAGTGACTATTGAAGT
TATAATTGTATTAAATTAATGCTAATAATTTGGATATTTTATTTTATTTTTGGCTGCTCGGGTAACTTTAGCCCTTAACCAAGCATATGT
GGGTTTTTTTGGTTGTTTTTTTTTGTTTTTTTTTTCTTTTTCCTTTTTGGGTACAGCTGTAAAATATTTGGATATAGGAAATGTTGTGTT
ATTCTTGCAGCCTTGATATTCAGGGTGGATTGTAAAATATAAATTTTTGTGAGATTTCAAAGATTAAGATTATTTTGATAACATTATTTA
CAGATTTAAAAGATGTGGTTATCACAAGTCTCGAGGGGGAAACTACTGCATAAAATAACTAACTTGGAATAAATATTTTGCATCAGTTTG
GATTGTCTTGTGTAAGAAGTATATTTTCTTTAAAATTAGATGAGTGGATTCTTTTTTAGGGGAAATATTTTTAGAAGTTGGGGGGAAATG
TGAATTCAGACACAACTGTTTCTCTATTTTAGCAGATACTTTTTTGATGCAGAAAAACCTGTGCAATAAATTACCAGTAATAAAGTCAGA

>54778_54778_5_MPRIP-GPBP1L1_MPRIP_chr17_16981390_ENST00000395811_GPBP1L1_chr1_46108171_ENST00000290795_length(amino acids)=404AA_BP=89
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP
SLNPEAGKQHQPCRPIGTPSGVWENPPSAKQPSKMLVIKKVSKEDPAAAFSAAFTSPGSHHANGNKLSSVVPSVYKNLVPKPVPPPSKPN
AWKANRMEHKSGSLSSSRESAFTSPISVTKPVVLASGAALSSPKESPSSTTPPIEISSSRLTKLTRRTTDRKSEFLKTLKDDRNGDFSEN
RDCDKLEDLEDNSTPEPKENGEEGCHQNGLALPVVEEGEVLSHSLEAEHRLLKAMGWQEYPENDENCLPLTEDELKEFHMKTEQLRRNGF

--------------------------------------------------------------
>54778_54778_6_MPRIP-GPBP1L1_MPRIP_chr17_16981390_ENST00000395811_GPBP1L1_chr1_46108171_ENST00000355105_length(transcript)=2254nt_BP=356nt
GCGGCCGCGCTGAGCCCCTAGCCCGCCGGGAGCGCCAGGCCGGCCAGGCCTGCGCCGCCGCCGCCGCCGCCGTCGCCGCCGCGCCGACCA
TGTCGGCAGCCAAGGAGAACCCGTGCAGGAAATTCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAGT
CGCATCTGCTCAACGACGAGGACCTGACGCAGGCAAAACCCATTTATGGCGGTTGGCTGCTCCTGGCTCCAGATGGGACCGACTTTGACA
ACCCAGTGCACCGGTCTCGGAAATGGCAGCGACGGTTCTTCATCCTTTACGAGCACGGCCTCTTGCGCTACGCCCTGGATGAGATGCCTT
CCTTGAATCCAGAAGCTGGCAAACAGCATCAGCCATGCAGACCTATTGGGACACCTTCTGGAGTATGGGAAAACCCGCCTAGTGCCAAGC
AACCCTCCAAGATGCTAGTTATCAAAAAAGTTTCCAAAGAGGATCCTGCTGCTGCCTTCTCTGCTGCATTCACCTCACCAGGATCTCACC
ATGCAAATGGGAACAAATTGTCATCCGTGGTTCCAAGTGTCTATAAGAACCTGGTTCCTAAGCCTGTACCACCTCCTTCCAAGCCTAATG
CATGGAAAGCTAACAGGATGGAGCACAAGTCAGGATCCCTTTCCTCTAGCCGGGAGTCTGCTTTTACCAGTCCAATCTCTGTTACCAAAC
CAGTGGTACTGGCTAGTGGTGCAGCTCTGAGTTCTCCCAAAGAGAGTCCCTCCAGCACCACCCCTCCAATTGAGATCAGCTCCTCTCGTC
TGACCAAGTTGACCCGCCGAACCACCGACAGGAAGAGTGAGTTCCTGAAAACTCTGAAGGATGACCGGAATGGAGACTTCTCAGAGAATA
GAGACTGTGACAAGCTGGAAGATTTGGAGGACAACAGCACACCTGAACCAAAGGAAAATGGGGAGGAAGGCTGTCATCAAAATGGTCTTG
CCCTCCCTGTAGTGGAAGAAGGGGAGGTTCTCTCACACTCTCTAGAAGCAGAGCACAGGTTATTGAAAGCTATGGGTTGGCAGGAATATC
CTGAAAATGATGAGAATTGCCTTCCCCTCACAGAGGATGAGCTCAAAGAGTTCCACATGAAGACAGAGCAGCTGAGAAGAAATGGCTTTG
GAAAGAATGGCTTCTTGCAGAGCCGCAGTTCCAGTCTGTTCTCCCCTTGGAGAAGCACTTGCAAAGCAGAGTTTGAGGACTCAGACACCG
AAACCAGTAGCAGTGAAACATCAGATGACGATGCCTGGAAGTAGGCATATAAATGCTCACAGTTAAATCTGACCCAGTAAACTCTGTGTG
TTTAGGGAGTATACAAAAGAAATCGTTCTTTTCCTTTTCTTATGTTGTTGAATACTTCATTCACAAGGGAAATAATCATATCCCAAAGAG
AGAGCAATTGGCTTGTTTTGCTTTTGTTATTGTTCTTCCCTGTTATCTGCTTTATAGAGAGAAGTTTGTGTGGTGGGACAGATTTTTTAA
ACACACTCACACACACACACACATACACACCCAGTATATATGGGGCGATGCACAGGTAGGAGCTGGCAGTGCAGGGAAGAGGAGACACTG
GTCTGCAGCAACAGCTTCTACTACCAGCCCTTGGGGCACTCACCCCTGTGATCAAGCAATCATTGTCAATGACAAAGTGACTATTGAAGT
TATAATTGTATTAAATTAATGCTAATAATTTGGATATTTTATTTTATTTTTGGCTGCTCGGGTAACTTTAGCCCTTAACCAAGCATATGT
GGGTTTTTTTGGTTGTTTTTTTTTGTTTTTTTTTTCTTTTTCCTTTTTGGGTACAGCTGTAAAATATTTGGATATAGGAAATGTTGTGTT
ATTCTTGCAGCCTTGATATTCAGGGTGGATTGTAAAATATAAATTTTTGTGAGATTTCAAAGATTAAGATTATTTTGATAACATTATTTA
CAGATTTAAAAGATGTGGTTATCACAAGTCTCGAGGGGGAAACTACTGCATAAAATAACTAACTTGGAATAAATATTTTGCATCAGTTTG
GATTGTCTTGTGTAAGAAGTATATTTTCTTTAAAATTAGATGAGTGGATTCTTTTTTAGGGGAAATATTTTTAGAAGTTGGGGGGAAATG
TGAATTCAGACACAACTGTTTCTCTATTTTAGCAGATACTTTTTTGATGCAGAAAAACCTGTGCAATAAATTACCAGTAATAAAGTCAGA

>54778_54778_6_MPRIP-GPBP1L1_MPRIP_chr17_16981390_ENST00000395811_GPBP1L1_chr1_46108171_ENST00000355105_length(amino acids)=404AA_BP=89
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP
SLNPEAGKQHQPCRPIGTPSGVWENPPSAKQPSKMLVIKKVSKEDPAAAFSAAFTSPGSHHANGNKLSSVVPSVYKNLVPKPVPPPSKPN
AWKANRMEHKSGSLSSSRESAFTSPISVTKPVVLASGAALSSPKESPSSTTPPIEISSSRLTKLTRRTTDRKSEFLKTLKDDRNGDFSEN
RDCDKLEDLEDNSTPEPKENGEEGCHQNGLALPVVEEGEVLSHSLEAEHRLLKAMGWQEYPENDENCLPLTEDELKEFHMKTEQLRRNGF

--------------------------------------------------------------
>54778_54778_7_MPRIP-GPBP1L1_MPRIP_chr17_16981390_ENST00000444976_GPBP1L1_chr1_46108171_ENST00000290795_length(transcript)=2247nt_BP=347nt
CTGAGCCCCTAGCCCGCCGGGAGCGCCAGGCCGGCCAGGCCTGCGCCGCCGCCGCCGCCGCCGTCGCCGCCGCGCCGACCATGTCGGCAG
CCAAGGAGAACCCGTGCAGGAAATTCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAGTCGCATCTGC
TCAACGACGAGGACCTGACGCAGGCAAAACCCATTTATGGCGGTTGGCTGCTCCTGGCTCCAGATGGGACCGACTTTGACAACCCAGTGC
ACCGGTCTCGGAAATGGCAGCGACGGTTCTTCATCCTTTACGAGCACGGCCTCTTGCGCTACGCCCTGGATGAGATGCCTTCCTTGAATC
CAGAAGCTGGCAAACAGCATCAGCCATGCAGACCTATTGGGACACCTTCTGGAGTATGGGAAAACCCGCCTAGTGCCAAGCAACCCTCCA
AGATGCTAGTTATCAAAAAAGTTTCCAAAGAGGATCCTGCTGCTGCCTTCTCTGCTGCATTCACCTCACCAGGATCTCACCATGCAAATG
GGAACAAATTGTCATCCGTGGTTCCAAGTGTCTATAAGAACCTGGTTCCTAAGCCTGTACCACCTCCTTCCAAGCCTAATGCATGGAAAG
CTAACAGGATGGAGCACAAGTCAGGATCCCTTTCCTCTAGCCGGGAGTCTGCTTTTACCAGTCCAATCTCTGTTACCAAACCAGTGGTAC
TGGCTAGTGGTGCAGCTCTGAGTTCTCCCAAAGAGAGTCCCTCCAGCACCACCCCTCCAATTGAGATCAGCTCCTCTCGTCTGACCAAGT
TGACCCGCCGAACCACCGACAGGAAGAGTGAGTTCCTGAAAACTCTGAAGGATGACCGGAATGGAGACTTCTCAGAGAATAGAGACTGTG
ACAAGCTGGAAGATTTGGAGGACAACAGCACACCTGAACCAAAGGAAAATGGGGAGGAAGGCTGTCATCAAAATGGTCTTGCCCTCCCTG
TAGTGGAAGAAGGGGAGGTTCTCTCACACTCTCTAGAAGCAGAGCACAGGTTATTGAAAGCTATGGGTTGGCAGGAATATCCTGAAAATG
ATGAGAATTGCCTTCCCCTCACAGAGGATGAGCTCAAAGAGTTCCACATGAAGACAGAGCAGCTGAGAAGAAATGGCTTTGGAAAGAATG
GCTTCTTGCAGAGCCGCAGTTCCAGTCTGTTCTCCCCTTGGAGAAGCACTTGCAAAGCAGAGTTTGAGGACTCAGACACCGAAACCAGTA
GCAGTGAAACATCAGATGACGATGCCTGGAAGTAGGCATATAAATGCTCACAGTTAAATCTGACCCAGTAAACTCTGTGTGTTTAGGGAG
TATACAAAAGAAATCGTTCTTTTCCTTTTCTTATGTTGTTGAATACTTCATTCACAAGGGAAATAATCATATCCCAAAGAGAGAGCAATT
GGCTTGTTTTGCTTTTGTTATTGTTCTTCCCTGTTATCTGCTTTATAGAGAGAAGTTTGTGTGGTGGGACAGATTTTTTAAACACACTCA
CACACACACACACATACACACCCAGTATATATGGGGCGATGCACAGGTAGGAGCTGGCAGTGCAGGGAAGAGGAGACACTGGTCTGCAGC
AACAGCTTCTACTACCAGCCCTTGGGGCACTCACCCCTGTGATCAAGCAATCATTGTCAATGACAAAGTGACTATTGAAGTTATAATTGT
ATTAAATTAATGCTAATAATTTGGATATTTTATTTTATTTTTGGCTGCTCGGGTAACTTTAGCCCTTAACCAAGCATATGTGGGTTTTTT
TGGTTGTTTTTTTTTGTTTTTTTTTTCTTTTTCCTTTTTGGGTACAGCTGTAAAATATTTGGATATAGGAAATGTTGTGTTATTCTTGCA
GCCTTGATATTCAGGGTGGATTGTAAAATATAAATTTTTGTGAGATTTCAAAGATTAAGATTATTTTGATAACATTATTTACAGATTTAA
AAGATGTGGTTATCACAAGTCTCGAGGGGGAAACTACTGCATAAAATAACTAACTTGGAATAAATATTTTGCATCAGTTTGGATTGTCTT
GTGTAAGAAGTATATTTTCTTTAAAATTAGATGAGTGGATTCTTTTTTAGGGGAAATATTTTTAGAAGTTGGGGGGAAATGTGAATTCAG

>54778_54778_7_MPRIP-GPBP1L1_MPRIP_chr17_16981390_ENST00000444976_GPBP1L1_chr1_46108171_ENST00000290795_length(amino acids)=404AA_BP=89
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP
SLNPEAGKQHQPCRPIGTPSGVWENPPSAKQPSKMLVIKKVSKEDPAAAFSAAFTSPGSHHANGNKLSSVVPSVYKNLVPKPVPPPSKPN
AWKANRMEHKSGSLSSSRESAFTSPISVTKPVVLASGAALSSPKESPSSTTPPIEISSSRLTKLTRRTTDRKSEFLKTLKDDRNGDFSEN
RDCDKLEDLEDNSTPEPKENGEEGCHQNGLALPVVEEGEVLSHSLEAEHRLLKAMGWQEYPENDENCLPLTEDELKEFHMKTEQLRRNGF

--------------------------------------------------------------
>54778_54778_8_MPRIP-GPBP1L1_MPRIP_chr17_16981390_ENST00000444976_GPBP1L1_chr1_46108171_ENST00000355105_length(transcript)=2245nt_BP=347nt
CTGAGCCCCTAGCCCGCCGGGAGCGCCAGGCCGGCCAGGCCTGCGCCGCCGCCGCCGCCGCCGTCGCCGCCGCGCCGACCATGTCGGCAG
CCAAGGAGAACCCGTGCAGGAAATTCCAGGCCAACATCTTCAACAAGAGCAAGTGTCAGAACTGCTTCAAGCCCCGCGAGTCGCATCTGC
TCAACGACGAGGACCTGACGCAGGCAAAACCCATTTATGGCGGTTGGCTGCTCCTGGCTCCAGATGGGACCGACTTTGACAACCCAGTGC
ACCGGTCTCGGAAATGGCAGCGACGGTTCTTCATCCTTTACGAGCACGGCCTCTTGCGCTACGCCCTGGATGAGATGCCTTCCTTGAATC
CAGAAGCTGGCAAACAGCATCAGCCATGCAGACCTATTGGGACACCTTCTGGAGTATGGGAAAACCCGCCTAGTGCCAAGCAACCCTCCA
AGATGCTAGTTATCAAAAAAGTTTCCAAAGAGGATCCTGCTGCTGCCTTCTCTGCTGCATTCACCTCACCAGGATCTCACCATGCAAATG
GGAACAAATTGTCATCCGTGGTTCCAAGTGTCTATAAGAACCTGGTTCCTAAGCCTGTACCACCTCCTTCCAAGCCTAATGCATGGAAAG
CTAACAGGATGGAGCACAAGTCAGGATCCCTTTCCTCTAGCCGGGAGTCTGCTTTTACCAGTCCAATCTCTGTTACCAAACCAGTGGTAC
TGGCTAGTGGTGCAGCTCTGAGTTCTCCCAAAGAGAGTCCCTCCAGCACCACCCCTCCAATTGAGATCAGCTCCTCTCGTCTGACCAAGT
TGACCCGCCGAACCACCGACAGGAAGAGTGAGTTCCTGAAAACTCTGAAGGATGACCGGAATGGAGACTTCTCAGAGAATAGAGACTGTG
ACAAGCTGGAAGATTTGGAGGACAACAGCACACCTGAACCAAAGGAAAATGGGGAGGAAGGCTGTCATCAAAATGGTCTTGCCCTCCCTG
TAGTGGAAGAAGGGGAGGTTCTCTCACACTCTCTAGAAGCAGAGCACAGGTTATTGAAAGCTATGGGTTGGCAGGAATATCCTGAAAATG
ATGAGAATTGCCTTCCCCTCACAGAGGATGAGCTCAAAGAGTTCCACATGAAGACAGAGCAGCTGAGAAGAAATGGCTTTGGAAAGAATG
GCTTCTTGCAGAGCCGCAGTTCCAGTCTGTTCTCCCCTTGGAGAAGCACTTGCAAAGCAGAGTTTGAGGACTCAGACACCGAAACCAGTA
GCAGTGAAACATCAGATGACGATGCCTGGAAGTAGGCATATAAATGCTCACAGTTAAATCTGACCCAGTAAACTCTGTGTGTTTAGGGAG
TATACAAAAGAAATCGTTCTTTTCCTTTTCTTATGTTGTTGAATACTTCATTCACAAGGGAAATAATCATATCCCAAAGAGAGAGCAATT
GGCTTGTTTTGCTTTTGTTATTGTTCTTCCCTGTTATCTGCTTTATAGAGAGAAGTTTGTGTGGTGGGACAGATTTTTTAAACACACTCA
CACACACACACACATACACACCCAGTATATATGGGGCGATGCACAGGTAGGAGCTGGCAGTGCAGGGAAGAGGAGACACTGGTCTGCAGC
AACAGCTTCTACTACCAGCCCTTGGGGCACTCACCCCTGTGATCAAGCAATCATTGTCAATGACAAAGTGACTATTGAAGTTATAATTGT
ATTAAATTAATGCTAATAATTTGGATATTTTATTTTATTTTTGGCTGCTCGGGTAACTTTAGCCCTTAACCAAGCATATGTGGGTTTTTT
TGGTTGTTTTTTTTTGTTTTTTTTTTCTTTTTCCTTTTTGGGTACAGCTGTAAAATATTTGGATATAGGAAATGTTGTGTTATTCTTGCA
GCCTTGATATTCAGGGTGGATTGTAAAATATAAATTTTTGTGAGATTTCAAAGATTAAGATTATTTTGATAACATTATTTACAGATTTAA
AAGATGTGGTTATCACAAGTCTCGAGGGGGAAACTACTGCATAAAATAACTAACTTGGAATAAATATTTTGCATCAGTTTGGATTGTCTT
GTGTAAGAAGTATATTTTCTTTAAAATTAGATGAGTGGATTCTTTTTTAGGGGAAATATTTTTAGAAGTTGGGGGGAAATGTGAATTCAG

>54778_54778_8_MPRIP-GPBP1L1_MPRIP_chr17_16981390_ENST00000444976_GPBP1L1_chr1_46108171_ENST00000355105_length(amino acids)=404AA_BP=89
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMP
SLNPEAGKQHQPCRPIGTPSGVWENPPSAKQPSKMLVIKKVSKEDPAAAFSAAFTSPGSHHANGNKLSSVVPSVYKNLVPKPVPPPSKPN
AWKANRMEHKSGSLSSSRESAFTSPISVTKPVVLASGAALSSPKESPSSTTPPIEISSSRLTKLTRRTTDRKSEFLKTLKDDRNGDFSEN
RDCDKLEDLEDNSTPEPKENGEEGCHQNGLALPVVEEGEVLSHSLEAEHRLLKAMGWQEYPENDENCLPLTEDELKEFHMKTEQLRRNGF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MPRIP-GPBP1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMPRIPchr17:16981390chr1:46108171ENST00000341712+3242_38389.01231.0F-actin
HgeneMPRIPchr17:16981390chr1:46108171ENST00000395804+3232_38389.01026.0F-actin
HgeneMPRIPchr17:16981390chr1:46108171ENST00000395811+3232_38389.01039.0F-actin
HgeneMPRIPchr17:16981390chr1:46108171ENST00000444976+3222_38389.01001.0F-actin
HgeneMPRIPchr17:16981390chr1:46108171ENST00000341712+324824_87989.01231.0PPP1R12A
HgeneMPRIPchr17:16981390chr1:46108171ENST00000395804+323824_87989.01026.0PPP1R12A
HgeneMPRIPchr17:16981390chr1:46108171ENST00000395811+323824_87989.01039.0PPP1R12A
HgeneMPRIPchr17:16981390chr1:46108171ENST00000444976+322824_87989.01001.0PPP1R12A
HgeneMPRIPchr17:16981390chr1:46108171ENST00000341712+324546_82489.01231.0RHOA
HgeneMPRIPchr17:16981390chr1:46108171ENST00000395804+323546_82489.01026.0RHOA
HgeneMPRIPchr17:16981390chr1:46108171ENST00000395811+323546_82489.01039.0RHOA
HgeneMPRIPchr17:16981390chr1:46108171ENST00000444976+322546_82489.01001.0RHOA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MPRIP-GPBP1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MPRIP-GPBP1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource