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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MPRIP-TNFRSF13B (FusionGDB2 ID:54792)

Fusion Gene Summary for MPRIP-TNFRSF13B

check button Fusion gene summary
Fusion gene informationFusion gene name: MPRIP-TNFRSF13B
Fusion gene ID: 54792
HgeneTgene
Gene symbol

MPRIP

TNFRSF13B

Gene ID

23164

23495

Gene namemyosin phosphatase Rho interacting proteinTNF receptor superfamily member 13B
SynonymsM-RIP|MRIP|RHOIP3|RIP3|p116RipCD267|CVID|CVID2|IGAD2|RYZN|TACI|TNFRSF14B
Cytomap

17p11.2

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionmyosin phosphatase Rho-interacting proteinRho interacting protein 3tumor necrosis factor receptor superfamily member 13Btransmembrane activator and CAML interactortumor necrosis factor receptor 13B
Modification date2020031320200329
UniProtAcc

Q6WCQ1

.
Ensembl transtripts involved in fusion geneENST00000395807, ENST00000341712, 
ENST00000395804, ENST00000395806, 
ENST00000395811, ENST00000444976, 
ENST00000261652, ENST00000437538, 
ENST00000579315, ENST00000583789, 
ENST00000581616, 
Fusion gene scores* DoF score24 X 12 X 11=31681 X 2 X 1=2
# samples 231
** MAII scorelog2(23/3168*10)=-3.78386656913523
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/2*10)=2.32192809488736
Context

PubMed: MPRIP [Title/Abstract] AND TNFRSF13B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMPRIP(16946285)-TNFRSF13B(16855897), # samples:3
TNFRSF13B(16852052)-MPRIP(16960950), # samples:3
Anticipated loss of major functional domain due to fusion event.MPRIP-TNFRSF13B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MPRIP-TNFRSF13B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MPRIP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TNFRSF13B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3M1-01AMPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
ChimerDB4SARCTCGA-DX-A3M1-01AMPRIPchr17

16946285

-TNFRSF13Bchr17

16855897

-
ChimerDB4SARCTCGA-DX-A3M1-01AMPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-


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Fusion Gene ORF analysis for MPRIP-TNFRSF13B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000395807ENST00000261652MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
3UTR-3CDSENST00000395807ENST00000437538MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
3UTR-3CDSENST00000395807ENST00000579315MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
3UTR-3CDSENST00000395807ENST00000583789MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
3UTR-5UTRENST00000395807ENST00000581616MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
3UTR-5UTRENST00000395807ENST00000581616MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
3UTR-intronENST00000395807ENST00000261652MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
3UTR-intronENST00000395807ENST00000437538MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
3UTR-intronENST00000395807ENST00000579315MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
3UTR-intronENST00000395807ENST00000583789MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-5UTRENST00000341712ENST00000581616MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
5CDS-5UTRENST00000341712ENST00000581616MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-5UTRENST00000395804ENST00000581616MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
5CDS-5UTRENST00000395804ENST00000581616MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-5UTRENST00000395806ENST00000581616MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
5CDS-5UTRENST00000395806ENST00000581616MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-5UTRENST00000395811ENST00000581616MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
5CDS-5UTRENST00000395811ENST00000581616MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-5UTRENST00000444976ENST00000581616MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
5CDS-5UTRENST00000444976ENST00000581616MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000341712ENST00000261652MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000341712ENST00000437538MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000341712ENST00000579315MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000341712ENST00000583789MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000395804ENST00000261652MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000395804ENST00000437538MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000395804ENST00000579315MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000395804ENST00000583789MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000395806ENST00000261652MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000395806ENST00000437538MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000395806ENST00000579315MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000395806ENST00000583789MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000395811ENST00000261652MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000395811ENST00000437538MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000395811ENST00000579315MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000395811ENST00000583789MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000444976ENST00000261652MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000444976ENST00000437538MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000444976ENST00000579315MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
5CDS-intronENST00000444976ENST00000583789MPRIPchr17

16946285

+TNFRSF13Bchr17

16855897

-
Frame-shiftENST00000341712ENST00000261652MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
Frame-shiftENST00000341712ENST00000579315MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
Frame-shiftENST00000341712ENST00000583789MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
Frame-shiftENST00000395804ENST00000261652MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
Frame-shiftENST00000395804ENST00000579315MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
Frame-shiftENST00000395804ENST00000583789MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
Frame-shiftENST00000395806ENST00000261652MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
Frame-shiftENST00000395806ENST00000579315MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
Frame-shiftENST00000395806ENST00000583789MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
Frame-shiftENST00000395811ENST00000261652MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
Frame-shiftENST00000395811ENST00000579315MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
Frame-shiftENST00000395811ENST00000583789MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
Frame-shiftENST00000444976ENST00000261652MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
Frame-shiftENST00000444976ENST00000579315MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
Frame-shiftENST00000444976ENST00000583789MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
In-frameENST00000341712ENST00000437538MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
In-frameENST00000395804ENST00000437538MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
In-frameENST00000395806ENST00000437538MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
In-frameENST00000395811ENST00000437538MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-
In-frameENST00000444976ENST00000437538MPRIPchr17

16946285

+TNFRSF13Bchr17

16852297

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MPRIP-TNFRSF13B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MPRIP-TNFRSF13B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:16946285/chr17:16855897)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPRIP

Q6WCQ1

.
FUNCTION: Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTNFRSF13Bchr17:16946285chr17:16852297ENST000002616521570_10466294.0RepeatNote=TNFR-Cys 2
TgeneTNFRSF13Bchr17:16946285chr17:16852297ENST000005837890433_6720248.0RepeatNote=TNFR-Cys 1
TgeneTNFRSF13Bchr17:16946285chr17:16852297ENST000005837890470_10420248.0RepeatNote=TNFR-Cys 2
TgeneTNFRSF13Bchr17:16946285chr17:16852297ENST0000026165215187_29366294.0Topological domainCytoplasmic
TgeneTNFRSF13Bchr17:16946285chr17:16852297ENST0000058378904187_29320248.0Topological domainCytoplasmic
TgeneTNFRSF13Bchr17:16946285chr17:16852297ENST0000026165215166_18666294.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
TgeneTNFRSF13Bchr17:16946285chr17:16852297ENST0000058378904166_18620248.0TransmembraneHelical%3B Signal-anchor for type III membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMPRIPchr17:16946285chr17:16852297ENST00000341712+124673_977411231.0Coiled coilOntology_term=ECO:0000255
HgeneMPRIPchr17:16946285chr17:16852297ENST00000395804+123673_977411026.0Coiled coilOntology_term=ECO:0000255
HgeneMPRIPchr17:16946285chr17:16852297ENST00000395811+123673_977411039.0Coiled coilOntology_term=ECO:0000255
HgeneMPRIPchr17:16946285chr17:16852297ENST00000444976+122673_977411001.0Coiled coilOntology_term=ECO:0000255
HgeneMPRIPchr17:16946285chr17:16852297ENST00000341712+124179_252411231.0Compositional biasNote=Ser-rich
HgeneMPRIPchr17:16946285chr17:16852297ENST00000395804+123179_252411026.0Compositional biasNote=Ser-rich
HgeneMPRIPchr17:16946285chr17:16852297ENST00000395811+123179_252411039.0Compositional biasNote=Ser-rich
HgeneMPRIPchr17:16946285chr17:16852297ENST00000444976+122179_252411001.0Compositional biasNote=Ser-rich
HgeneMPRIPchr17:16946285chr17:16852297ENST00000341712+124387_483411231.0DomainPH 2
HgeneMPRIPchr17:16946285chr17:16852297ENST00000341712+12443_150411231.0DomainPH 1
HgeneMPRIPchr17:16946285chr17:16852297ENST00000395804+123387_483411026.0DomainPH 2
HgeneMPRIPchr17:16946285chr17:16852297ENST00000395804+12343_150411026.0DomainPH 1
HgeneMPRIPchr17:16946285chr17:16852297ENST00000395811+123387_483411039.0DomainPH 2
HgeneMPRIPchr17:16946285chr17:16852297ENST00000395811+12343_150411039.0DomainPH 1
HgeneMPRIPchr17:16946285chr17:16852297ENST00000444976+122387_483411001.0DomainPH 2
HgeneMPRIPchr17:16946285chr17:16852297ENST00000444976+12243_150411001.0DomainPH 1
TgeneTNFRSF13Bchr17:16946285chr17:16852297ENST000002616521533_6766294.0RepeatNote=TNFR-Cys 1
TgeneTNFRSF13Bchr17:16946285chr17:16852297ENST00000261652151_16566294.0Topological domainExtracellular
TgeneTNFRSF13Bchr17:16946285chr17:16852297ENST00000583789041_16520248.0Topological domainExtracellular


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Fusion Gene Sequence for MPRIP-TNFRSF13B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MPRIP-TNFRSF13B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMPRIPchr17:16946285chr17:16852297ENST00000341712+1242_38341.01231.0F-actin
HgeneMPRIPchr17:16946285chr17:16852297ENST00000395804+1232_38341.01026.0F-actin
HgeneMPRIPchr17:16946285chr17:16852297ENST00000395811+1232_38341.01039.0F-actin
HgeneMPRIPchr17:16946285chr17:16852297ENST00000444976+1222_38341.01001.0F-actin
HgeneMPRIPchr17:16946285chr17:16852297ENST00000341712+124824_87941.01231.0PPP1R12A
HgeneMPRIPchr17:16946285chr17:16852297ENST00000395804+123824_87941.01026.0PPP1R12A
HgeneMPRIPchr17:16946285chr17:16852297ENST00000395811+123824_87941.01039.0PPP1R12A
HgeneMPRIPchr17:16946285chr17:16852297ENST00000444976+122824_87941.01001.0PPP1R12A
HgeneMPRIPchr17:16946285chr17:16852297ENST00000341712+124546_82441.01231.0RHOA
HgeneMPRIPchr17:16946285chr17:16852297ENST00000395804+123546_82441.01026.0RHOA
HgeneMPRIPchr17:16946285chr17:16852297ENST00000395811+123546_82441.01039.0RHOA
HgeneMPRIPchr17:16946285chr17:16852297ENST00000444976+122546_82441.01001.0RHOA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MPRIP-TNFRSF13B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MPRIP-TNFRSF13B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource